MORALES-NEBREDA L, Chi M, Lecuona E, Chandel NS, e. Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury. J Virol Methods. 2014 Sep 17. Abstract
submitted by kickingbird at Sep, 30, 2014 from J Virol Methods. 2014 Sep 17 (via http://www.ncbi.nlm.nih.gov/pubmed/25239366)
Infection of mice with human or murine adapted influenza A viruses results in a severe pneumonia. However, the results of studies from different laboratories show surprising variability, even in genetically ... FAN S, Hatta M, Kim JH, Le MQ, et al. Amino Acid Changes in the Influenza A Virus PA Protein that Attenuate Avian H5N1 Viruses in Mammals. J Virol. 2014 Sep 17. Abstract
submitted by kickingbird at Sep, 30, 2014 from J Virol. 2014 Sep 17 (via http://www.ncbi.nlm.nih.gov/pubmed/25231317)
The influenza viral polymerase complex affects host tropism and pathogenicity. In particular, several amino acids in the PB2 polymerase subunit are essential for the efficient replication of avian influenza ... CAO M, Wei C, Zhao L, Wang J, et al. DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activity. J Virol. 2014 Sep 24. pii: JVI.02475. Abstract
submitted by kickingbird at Sep, 30, 2014 from J Virol. 2014 Sep 24. pii: JVI.02475 (via http://www.ncbi.nlm.nih.gov/pubmed/25253355)
The RNA-dependent RNA polymerase (RdRp) of influenza A virus is a heterotrimeric complex composed by PB1, PB2 and PA subunits. The interplay between host factors and the three subunits of the RdRp is critical ... LOVEDAY EK, Diederich S, Pasick J, Jean F, et al. Human microRNA-24 modulates highly pathogenic avian-origin H5N1 influenza A virus infection in A549 cells by targeting secretory pathway furin. J Gen Virol. 2014 Sep 18. Abstract
submitted by kickingbird at Sep, 30, 2014 from J Gen Virol. 2014 Sep 18 (via http://www.ncbi.nlm.nih.gov/pubmed/25234642)
A common critical cellular event many human enveloped viruses share is the requirement for proteolytic cleavage of the viral glycoprotein by furin in the host secretory pathway. For example, the furin-dependent ... LEON B, Ballesteros-Tato A, Randall TD, Lund FE, e. Prolonged antigen presentation by immune complex-binding dendritic cells programs the proliferative capacity of memory CD8 T cells. J Exp Med. 2014;211:1637-55. Abstract
submitted by kickingbird at Sep, 30, 2014 from J Exp Med. 2014;211:1637-55 (via http://www.ncbi.nlm.nih.gov/pubmed/25002751)
The commitment of naive CD8 T cells to effector or memory cell fates can occur after a single day of antigenic stimulation even though virus-derived antigens (Ags) are still presented by DCs long after ... YUAN XY, Wang YL, Yu KX, Zhang YX, et al. Isolation and genetic characterization of avian influenza virus H4N6 from ducks in China. Arch Virol. 2014 Sep 24. Abstract
submitted by kickingbird at Sep, 30, 2014 from Arch Virol. 2014 Sep 24 (via http://www.ncbi.nlm.nih.gov/pubmed/25248626)
An avian influenza virus (AIV) strain belonging to the H4 subtype and provisionally designated as A/duck/China/J1/2012(H4N6) was isolated from diseased ducks with respiratory disease at a commercial poultry ... SVANCAROVA P, Svetlikova D, Betakova T. Synergic and antagonistic effect of small hairpin RNAs targeting the NS gene of the influenza A virus in cells and mice. Virus Res. 2014 Sep 3. pii: S0168-1702. Abstract
submitted by kickingbird at Sep, 15, 2014 from Virus Res. 2014 Sep 3. pii: S0168-1702 (via http://www.ncbi.nlm.nih.gov/pubmed/25192613)
In the present study, we demonstrate the effect of individual and mixtures of shRNAs targeting the NS gene to treat an established infection of influenza A virus (IAV). We prepared 10 shRNAs targeting ... HILLAIRE ML, van Eijk M, Vogelzang-van Trierum SE,. Assessment of the antiviral properties of recombinant surfactant protein D against influenza B virus in vitro. Virus Res. 2014 Sep 5. Abstract
submitted by kickingbird at Sep, 15, 2014 from Virus Res. 2014 Sep 5 (via http://www.ncbi.nlm.nih.gov/pubmed/25200748)
The armamentarium of antiviral drugs against influenza viruses is limited. Furthermore, influenza viruses emerge that are resistant to existing antiviral drugs like the M2 and NA inhibitors. Therefore, ... CHENG K, Yu Z, Chai H, Sun W, et al. PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice. Virology. 2014 Sep 3;468-470C:207-213.. Abstract
submitted by kickingbird at Sep, 15, 2014 from Virology. 2014 Sep 3;468-470C:207-213. (via http://www.ncbi.nlm.nih.gov/pubmed/25194918)
H6N1 avian influenza viruses (AIVs) may pose a potential human risk as suggested by the first documented naturally-acquired human H6N1 virus infection in 2013. Here, we set out to elucidate viral determinants ... OTHUMPANGAT S, Noti JD, Beezhold DH. Lung epithelial cells resist influenza A infection by inducing the expression of cytochrome c oxidase VIc which is modulated by miRNA 4276. Virology. 2014 Sep 6;468-470C:256-264.. Abstract
submitted by kickingbird at Sep, 15, 2014 from Virology. 2014 Sep 6;468-470C:256-264. (via http://www.ncbi.nlm.nih.gov/pubmed/25203353)
Influenza virus infection induces several changes in host miRNA profile, host cell death and tissue damage. Cytochrome c is a regulator of the intrinsic apoptotic pathway and is altered during viral infections. ... LIU W, Fan H, Raghwani J, Tsan-Yuk Lam T, et al. Occurrence and reassortment of avian influenza A (H7N9) viruses derived from coinfected birds in China. J Virol. 2014 Sep 10. pii: JVI.01777-14.. Abstract
submitted by kickingbird at Sep, 15, 2014 from J Virol. 2014 Sep 10. pii: JVI.01777-14. (via http://www.ncbi.nlm.nih.gov/pubmed/25210174)
Over the course of two waves of infection, H7N9 avian influenza A virus has caused 436 human infections and claimed 170 lives in China as of July 2014. To investigate the prevalence and genetic diversity ... DANZY S, Studdard LR, Manicassamy B, Solorzano A,. Mutations to PB2 and NP proteins of an avian influenza virus combine to confer efficient growth in primary human respiratory cells. J Virol. 2014 Sep 10. pii: JVI.01093-14.. Abstract
submitted by kickingbird at Sep, 15, 2014 from J Virol. 2014 Sep 10. pii: JVI.01093-14. (via http://www.ncbi.nlm.nih.gov/pubmed/25210184)
Influenza pandemics occur when influenza A viruses (IAV) adapted to other host species enter humans and spread through the population. Pandemics are relatively rare due to host restriction of IAV: strains ... MELIOPOULOS VA, Karlsson EA, Kercher L, Cline T, e. Human H7N9 and H5N1 influenza viruses differ in induction of cytokines and tissue tropism. J Virol. 2014 Sep 10. pii: JVI.01571-14. Abstract
submitted by kickingbird at Sep, 15, 2014 from J Virol. 2014 Sep 10. pii: JVI.01571-14 (via http://www.ncbi.nlm.nih.gov/pubmed/25210188)
Since emerging in 2013, the avian-origin H7N9 influenza viruses have resulted in over 400 human infections leading to 115 deaths to date. Although the epidemiology differs from human highly pathogenic ... RITH S, Davis CT, Duong V, Sar B, et al. Identification of molecular markers associated with alteration of receptor-binding specificity in a novel genotype of highly pathogenic avian influenza A(H5N1) viruses detected in Cambodia in 2013. J Virol. 2014 Sep 10. pii: JVI.01887-14.. Abstract
submitted by kickingbird at Sep, 15, 2014 from J Virol. 2014 Sep 10. pii: JVI.01887-14. (via http://www.ncbi.nlm.nih.gov/pubmed/25210193)
Human infections with influenza A(H5N1) virus in Cambodia increased sharply during 2013. Molecular characterization of viruses detected in clinical specimens from human cases revealed the presence of mutations ... Matloob Husain and Chen-Yi Cheung. Histone Deacetylase 6 Inhibits Influenza A Virus Release by Downregulating the Trafficking of Viral Components to the Plasma Membrane via Its Substrate, Acetylated Microtubules. J. Virol. October 2014 vol. 88 no. 19 11229-11239. Abstract
submitted by kickingbird at Sep, 12, 2014 from J. Virol. October 2014 vol. 88 no. 19 11229-11239 (via http://jvi.asm.org/content/88/19/11229.abstract?sid=e1317f1f)
Mammalian cells produce many proteins, such as IFITM3, ISG15, MxA, and viperin, that inhibit influenza A virus (IAV) infection. Here, we show that a new class of host protein, histone deacetylase 6 (HDAC6), ... Caselton DL, Arunga G, Emukule G, Muthoka P, Mayie. Does the length of specimen storage affect influenza testing results by real-time reverse transcription-polymerase chain reaction? An analysis of influenza surveillance specimens, 2008 to 2010. Euro Surveill. 2014;19(36):pii=20893.. Abstract
submitted by kickingbird at Sep, 12, 2014 from Euro Surveill. 2014;19(36):pii=20893. (via http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=2)
In some influenza surveillance systems, timely transport to laboratories for reverse transcription-polymerase chain reaction (RT-PCR) testing is challenging. Guidelines suggest that samples can be stored ... YORK A, Hutchinson EC, Fodor E. Interactome analysis of the influenza A virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication. J Virol. 2014 Sep 3. pii:. Abstract
submitted by kickingbird at Sep, 7, 2014 from J Virol. 2014 Sep 3. pii: (via http://www.ncbi.nlm.nih.gov/pubmed/25187537)
The negative-sense RNA genome of influenza A virus is transcribed and replicated by the viral RNA-dependent RNA polymerase (RdRP). The viral RdRP is an important host range determinant, indicating that ... MAIR CM, Meyer T, Schneider K, Huang Q, et al. A histidine residue of the influenza virus hemagglutinin controls the pH dependence of the conformational change mediating membrane fusion. J Virol. 2014 Sep 3. pii: JVI.01704-14. Abstract
submitted by kickingbird at Sep, 7, 2014 from J Virol. 2014 Sep 3. pii: JVI.01704-14 (via http://www.ncbi.nlm.nih.gov/pubmed/25187542)
The conformational change of the influenza virus hemagglutinin (HA) protein mediating the fusion between the virus envelope and the endosomal membrane was hypothesized to be induced by protonation of specific ... Marc D.. Influenza virus non-structural protein NS1: interferon-antagonism and beyond. J Gen Virol. 2014 Sep 2. Abstract
submitted by kickingbird at Sep, 7, 2014 from J Gen Virol. 2014 Sep 2 (via http://www.ncbi.nlm.nih.gov/pubmed/25182164)
Most viruses express one or several proteins that counter the anti-viral defences of the host-cell. This is the task of non-structural protein NS1 in influenza viruses. Absent from the viral particle but ... Colvin MT, Andreas LB, Chou JJ, Griffin RG.. Proton Association Constants of His-37 in the Influenza-A M218-60 Dimer-of-Dimers. Biochemistry. 2014 Sep 3. Abstract
submitted by kickingbird at Sep, 7, 2014 from Biochemistry. 2014 Sep 3 (via http://www.ncbi.nlm.nih.gov/pubmed/25184631)
The membrane protein M2 from influenza-A forms a single pass transmembrane helix that assembles in lipid membrane as homo-tetramers whose primary function is to act as a proton gate for viral acidification. ... 5153 items, 20/Page, Page[174/258][|<<] [|<] [171] [172] [173] [174] [175] [176] [177] [178] [179] [180] [>|] [>>|] |
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