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2024-4-22 14:41:59
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Fu X, Wang Q, Ma B, Zhang B, Sun K, Yu X, Ye Z, Zh. Advances in Detection Techniques for the H5N1 Avian Influenza Virus. Int J Mol Sci. 2023 Dec 5;24(24):17157.  Abstract  
submitted by kickingbird at Mar, 31, 2024 from Int J Mol Sci. 2023 Dec 5;24(24):17157 (via https://www.mdpi.com/1422-0067/24/24/17157)
Avian influenza is caused by avian influenza virus infection; the H5N1 avian influenza virus is a highly pathogenic subtype, affecting poultry and human health. Since the discovery of the highly pathogenic ...

Wang Q, Luo J, Li B, Ye Q, Xu W, Gao F, Zhou L, Lu. Reduction in Interferon-Stimulated Genes Contributes to High-Yield Production of Influenza Virus in Suspension MDCK Cells. Vaccines (Basel). 2024 Mar 9;12(3):287.  Abstract  
submitted by kickingbird at Mar, 29, 2024 from Vaccines (Basel). 2024 Mar 9;12(3):287 (via https://www.mdpi.com/2076-393X/12/3/287)
Compared with the traditional vaccine produced in embryonated chicken eggs, cell-based manufacturing represented by the Madin-Darby canine kidney (MDCK) cell line has a larger production scale and reduces ...

Shi H, Ross TM. Inactivated recombinant influenza vaccine: the promising direction for the next generation of influenza vaccine. Expert Rev Vaccines. 2024 Mar 20.  Abstract  
submitted by kickingbird at Mar, 22, 2024 from Expert Rev Vaccines. 2024 Mar 20 (via https://www.tandfonline.com/doi/full/10.1080/14760584.2024.2)
Introduction: Vaccination is the most effective method to control the prevalence of seasonal influenza and the most widely used influenza vaccine is the inactivated influenza vaccine (IIV). Each season, ...

Yang RS, Traver M, Barefoot N, Stephens T, Alabanz. Mosaic quadrivalent influenza vaccine single nanoparticle characterization. Sci Rep. 2024 Feb 24;14(1):4534.  Abstract  
submitted by kickingbird at Feb, 26, 2024 from Sci Rep. 2024 Feb 24;14(1):4534 (via https://www.nature.com/articles/s41598-024-54876-2)
Recent work by our laboratory and others indicates that co-display of multiple antigens on protein-based nanoparticles may be key to induce cross-reactive antibodies that provide broad protection against ...

Li F, Liu B, Xiong Y, Zhang Z, Zhang Q, Qiu R, Pen. Enhanced Downstream Processing for a Cell-Based Avian Influenza (H5N1) Vaccine. Vaccines (Basel). 2024 Jan 29;12(2):138.  Abstract  
submitted by kickingbird at Feb, 25, 2024 from Vaccines (Basel). 2024 Jan 29;12(2):138 (via https://www.mdpi.com/2076-393X/12/2/138)
H5N1 highly pathogenic avian influenza virus (HPAIV) infections pose a significant threat to human health, with a mortality rate of around 50%. Limited global approval of H5N1 HPAIV vaccines, excluding ...

Yang Z, Yu S, Xu Y, Zhao Y, Li L, Sun J, Wang X, G. The Screening and Mechanism of Influenza-Virus Sensitive MDCK Cell Lines for Influenza Vaccine Production. Diseases. 2024 Jan 10;12(1):20.  Abstract  
submitted by kickingbird at Jan, 22, 2024 from Diseases. 2024 Jan 10;12(1):20 (via https://www.mdpi.com/2079-9721/12/1/20)
Influenza is a potentially fatal acute respiratory viral disease caused by the influenza virus. Influenza viruses vary in antigenicity and spread rapidly, resulting in seasonal epidemics. Vaccination is ...

Howard LM, Jensen TL, Goll JB, Gelber CE, Bradley. Metabolomic Signatures Differentiate Immune Responses in Avian Influenza Vaccine Recipients. J Infect Dis. 2024 Jan 5:jiad611.  Abstract  
submitted by kickingbird at Jan, 6, 2024 from J Infect Dis. 2024 Jan 5:jiad611 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
Background: Avian influenza viruses pose significant risk to human health. Vaccines targeting the hemagglutinin of these viruses are poorly immunogenic without the use of adjuvants.Methods: Twenty healthy ...

Chen X, Huang Y, Gao P, Wu F, Han Y, Zhang C, Hu Z. Engineering of novel hemagglutinin biosensors for rapid detection and drug screening of Influenza A H7N9 virus. Int J Biol Macromol. 2023 Dec 30:129126.  Abstract  
submitted by kickingbird at Jan, 3, 2024 from Int J Biol Macromol. 2023 Dec 30:129126 (via https://www.sciencedirect.com/science/article/abs/pii/S01418)
New pathogenic influenza virus strains are constantly emerging, posing a serious risk to both human health and economic growth. To effectively control the spread of this virus, there is an urgent need ...

Wen F, Wang C, Guo J, Yu H, Yuan S, Li Y, Li Z, Hu. Development and application of a triplex real-time PCR assay for the detection of H3, H4, and H5 subtypes of avian influenza virus. Poult Sci. 2023 Nov 30;103(2):103333.  Abstract  
submitted by kickingbird at Dec, 20, 2023 from Poult Sci. 2023 Nov 30;103(2):103333 (via https://www.sciencedirect.com/science/article/pii/S003257912)
Avian influenza virus (AIV) poses a significant threat to the poultry industry and public health. Among the diverse AIV subtypes, H3, H4, and H5 are frequently detected in waterfowl and live poultry markets ...

Kapczynski DR, Chrzastek K, Shanmugasundaram R, Zs. Efficacy of recombinant H5 vaccines delivered in ovo or day of age in commercial broilers against the 2015 U.S. H5N2 clade 2.3.4.4c highly pathogenic avian Influenza virus. Virol J. 2023 Dec 15;20(1):298.  Abstract  
submitted by kickingbird at Dec, 17, 2023 from Virol J. 2023 Dec 15;20(1):298 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: Avian influenza is a highly contagious, agriculturally relevant disease that can severely affect the poultry industry and food supply. Eurasian-origin H5Nx highly pathogenic avian influenza ...

Li Y, Shang J, Luo J, Zhang F, Meng G, Feng Y, Jia. Rapid detection of H5 subtype avian influenza virus using CRISPR Cas13a based-lateral flow dipstick. Front Microbiol. 2023 Nov 29;14:1283210.  Abstract  
submitted by kickingbird at Dec, 15, 2023 from Front Microbiol. 2023 Nov 29;14:1283210 (via https://www.frontiersin.org/articles/10.3389/fmicb.2023.1283)
Due to its high mortality rate, highly pathogenic avian influenza (HPAI), a notifiable animal illness designated by the World Organisation for Animal Health (WOAH), has caused enormous financial losses ...

Zhou P, Qiu T, Wang X, Yang X, Shi H, Zhu C, Dai W. One HA stalk topping multiple heads as a novel influenza vaccine. Emerg Microbes Infect. 2023 Dec 4:2290838.  Abstract  
submitted by kickingbird at Dec, 5, 2023 from Emerg Microbes Infect. 2023 Dec 4:2290838 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2)
Classic chimeric hemagglutinin (cHA) was designed to induce immune responses against the conserved stalk domain of HA. However, it is unclear whether combining more than one HA head domain onto one stalk ...

Yuan L, Li X, Li M, Bi R, Li Y, Song J, Li W, Yan. In silico design of a broad-spectrum multiepitope vaccine against influenza virus. Int J Biol Macromol. 2023 Nov 13:128071.  Abstract  
submitted by kickingbird at Nov, 16, 2023 from Int J Biol Macromol. 2023 Nov 13:128071 (via https://www.sciencedirect.com/science/article/abs/pii/S01418)
Influenza remains a global health concern due to its potential to cause pandemics as a result of rapidly mutating influenza virus strains. Existing vaccines often struggle to keep up with these rapidly ...

Spackman E, Suarez DL, Lee CW, Pantin-Jackwood MJ, Lee SA, Youk S, Ibrahim S. Efficacy of inactivated and RNA particle vaccines against a North American Clade 2.3.4.4b H5 highly pathogenic avian influenza virus in chickens. Vaccine. 2023 Nov 4:S0264-410X(23)01285-9.  Abstract  
submitted by kickingbird at Nov, 7, 2023 from Vaccine. 2023 Nov 4:S0264-410X(23)01285-9 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Highly pathogenic avian influenza virus (HPAIV) has caused widespread outbreaks in poultry in the Americas. Because of the duration and extent of these outbreaks, vaccine use may be an additional tool ...

Li Y, Shang J, Wang Y, Luo J, Jiang W, Yin X, Zhan. Establishment of two assays based on reverse transcription recombinase-aided amplification technology for rapid detection of H5 subtype avian influenza virus. Microbiol Spectr. 2023 Oct 9:e0218623.  Abstract  
submitted by kickingbird at Oct, 12, 2023 from Microbiol Spectr. 2023 Oct 9:e0218623 (via https://journals.asm.org/doi/10.1128/spectrum.02186-23)
The avian influenza virus (AIV), a member of the type A influenza virus group, is harbored by avian hosts. The highly pathogenic H5 subtype of AIV has inflicted significant financial damage on the poultry ...

Yu J, Sreenivasan C, Sheng Z, Zhai SL, Wollman JW,. A recombinant chimeric influenza virus vaccine expressing the consensus H3 hemagglutinin elicits broad hemagglutination inhibition antibodies against divergent swine H3N2 influenza viruses. Vaccine. 2023 Sep 7:S0264-410X(23)01060-5.  Abstract  
submitted by kickingbird at Sep, 12, 2023 from Vaccine. 2023 Sep 7:S0264-410X(23)01060-5 (via https://pubmed.ncbi.nlm.nih.gov/37689544/)
The global distribution and ongoing evolution of type A swine influenza virus (IAV-S) continue to pose significant challenges against developing broadly protective vaccines to control swine influenza. ...

Chen YQ, Su GM, Zhang JH, Li B, Ma KX, Zhang X, Hu. HVT-vectored H7 vaccine protects chickens from lethal infection with the highly pathogenic H7N9 Avian influenza virus. Vet Microbiol. 2023 Aug 20;285:109852.  Abstract  
submitted by kickingbird at Sep, 10, 2023 from Vet Microbiol. 2023 Aug 20;285:109852 (via https://www.sciencedirect.com/science/article/abs/pii/S03781)
Since mid-2016, the highly pathogenic H7N9 subtype avian influenza virus (AIV) has threatened both public health and the poultry industry. Although a vaccination strategy has been deemed imperative to ...

Xiong F, Zhang C, Shang B, Zheng M, Wang Q, Ding Y. An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses. Emerg Microbes Infect. 2023 Sep 6:2256422.  Abstract  
submitted by kickingbird at Sep, 10, 2023 from Emerg Microbes Infect. 2023 Sep 6:2256422 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2)
Influenza virus is a prominent cause of respiratory illness in humans. Current influenza vaccines offer strain-specific immunity, while provide limited protection against drifted strains. Broad-spectrum ...

Le Y, Zhang J, Gong Z, Zhang Z, Nian X, Li X, Yu D. TRAF3 deficiency in MDCK cells improved sensitivity to the influenza A virus. Heliyon. 2023 Aug 21;9(9):e19246.  Abstract  
submitted by kickingbird at Sep, 10, 2023 from Heliyon. 2023 Aug 21;9(9):e19246 (via https://www.cell.com/heliyon/fulltext/S2405-8440(23)06454-X)
Tumor necrosis factor receptor-associated factor 3 (TRAF3), an adaptor protein, has significant and varying effects on immunity depending on cell types. The role of TRAF3 in Madin-Darby Canine Kidney Epithelial ...

David SC, Vadas O, Glas I, Schaub A, Luo B, D&acut. Inactivation mechanisms of influenza A virus under pH conditions encountered in aerosol particles as revealed by whole-virus HDX-MS. mSphere. 2023 Aug 18:e0022623.  Abstract  
submitted by kickingbird at Aug, 21, 2023 from mSphere. 2023 Aug 18:e0022623 (via https://journals.asm.org/doi/10.1128/msphere.00226-23)
Multiple respiratory viruses, including influenza A virus (IAV), can be transmitted via expiratory aerosol particles, and aerosol pH was recently identified as a major factor influencing airborne virus ...

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