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2019-5-22 10:02:56
Article

Zhao ZX, Cheng LP, Li M, Pang W, Wu FH. Discovery of novel acylhydrazone neuraminidase inhibitors. Eur J Med Chem. 2019 Apr 5;173:305-313.  Abstract  
submitted by kickingbird at Apr, 27, 2019 from Eur J Med Chem. 2019 Apr 5;173:305-313 (via https://www.sciencedirect.com/science/article/pii/S022352341)
Neuraminidase (NA) plays a crucial role in the replication and transmission of influenza virus. NA inhibitors have been developed as effective treatments for influenza A and B infections. In this paper, ...

Sawlwin DC, Graves Jones A, Albano FR. Modification of the vaccine manufacturing process improves the pyrogenicity profile of inactivated influenza vaccines in young children. Vaccine. 2019 Mar 29. pii: S0264-410X(19)30390-1..  Abstract  
submitted by kickingbird at Apr, 4, 2019 from Vaccine. 2019 Mar 29. pii: S0264-410X(19)30390-1. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
BACKGROUND: There were increased reports of fevers and febrile reactions in young children (particularly children aged METHODS: For each study, fever rates (any grade and severe) were determined for the ...

Ross TM, et al. A computationally designed H5 antigen shows immunological breadth of coverage and protects against drifting avian strains. Vaccine. 2019 Mar 21..  Abstract  
submitted by kickingbird at Mar, 26, 2019 from Vaccine. 2019 Mar 21. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Since the first identification of the H5N1 Goose/Guangdong lineage in 1996, this highly pathogenic avian influenza virus has spread worldwide, becoming endemic in domestic poultry. Sporadic transmission ...

Lindert K, Leav B, Heijnen E, Barrett J, Nicolay U. MF59-Adjuvanted Seasonal Trivalent Influenza Vaccine: Pooled Analysis of Safety in Older Adults ≥65 Years of Age. Int J Infect Dis. 2019 Mar 20..  Abstract  
submitted by kickingbird at Mar, 26, 2019 from Int J Infect Dis. 2019 Mar 20. (via https://www.ijidonline.com/article/S1201-9712(19)30149-3/pdf)
OBJECTIVE: To assess the long-term safety of MF59-adjuvanted trivalent influenza vaccine (aIIV3; Fluad?) in adults ≥65 years of age.METHODS: Data from 36 primary vaccination and 7 re-vaccination Phase ...

Puchades C, et al. Epitope mapping of diverse influenza Hemagglutinin drug candidates using HDX-MS. Sci Rep. 2019 Mar 18;9(1):4735.  Abstract  
submitted by kickingbird at Mar, 25, 2019 from Sci Rep. 2019 Mar 18;9(1):4735 (via https://www.nature.com/articles/s41598-019-41179-0)
Epitope characterization is critical for elucidating the mechanism of action of drug candidates. However, traditional high-resolution epitope mapping techniques are not well suited for screening numerous ...

Nogales A, et al. A novel fluorescent and bioluminescent Bi-Reporter influenza A virus (BIRFLU) to evaluate viral infections. J Virol. 2019 Mar 13.  Abstract  
submitted by kickingbird at Mar, 15, 2019 from J Virol. 2019 Mar 13 (via https://jvi.asm.org/content/early/2019/03/07/JVI.00032-19)
Studying influenza A virus (IAV) requires the use of secondary approaches to detect the presence of virus in infected cells. To overcome this problem, we and others have generated recombinant IAV expressing ...

Ting-Hui-Lin, et al. Improving immunogenicity of influenza virus H7N9 recombinant hemagglutinin for vaccine development. Vaccine. 2019 Mar 22;37(13):1897-1903..  Abstract  
submitted by kickingbird at Mar, 13, 2019 from Vaccine. 2019 Mar 22;37(13):1897-1903. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Human infections of novel avian influenza A virus (H7N9) emerged in early 2013 and caused about 40% case-fatality through 2017. Therefore, development of influenza H7N9 vaccines is critical for pandemic ...

Pramuwidyatama MG, et al. A Systematic Evaluation of Measures Against Highly Pathogenic Avian Influenza (HPAI) in Indonesia. Front Vet Sci. 2019 Feb 18;6:33..  Abstract  
submitted by kickingbird at Mar, 7, 2019 from Front Vet Sci. 2019 Feb 18;6:33. (via https://www.frontiersin.org/articles/10.3389/fvets.2019.0003)
Over the past years, many different control measures have been implemented to prevent HPAI infection. The national plan with numerous measures lead to problems in terms of prioritization and budget allocation. ...

Barnes B, et al. Modelling high pathogenic avian influenza outbreaks in the commercial poultry industry. Theor Popul Biol. 2019 Feb 27..  Abstract  
submitted by kickingbird at Mar, 3, 2019 from Theor Popul Biol. 2019 Feb 27. (via https://www.sciencedirect.com/science/article/pii/S004058091)
Highly pathogenic avian influenza (HPAI) outbreaks are devastating to poultry industries and pose a risk to human health. There is concern that demand for free-range poultry products could increase the ...

Hasan M, et al. Reverse vaccinology approach to design a novel multi-epitope subunit vaccine against avian influenza A (H7N9) virus. Microb Pathog. 2019 Feb 26.  Abstract  
submitted by kickingbird at Mar, 3, 2019 from Microb Pathog. 2019 Feb 26 (via https://www.sciencedirect.com/science/article/pii/S088240101)
H7N9, a novel strain of avian origin influenza was the first recorded incidence where a human was transited by a N9 type influenza virus. Effective vaccination against influenza A (H7N9) is a major concern, ...

Wang Z, et al. Enhanced cross-lineage protection induced by recombinant H9N2 avian influenza virus inactivated vaccine. Vaccine. 2019 Feb 20..  Abstract  
submitted by kickingbird at Feb, 25, 2019 from Vaccine. 2019 Feb 20. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
BACKGROUND: Antigenic drift of H9N2 low pathogenic avian influenza viruses (AIV) may result in vaccination failure in the poultry industry and thus a cross-protective vaccine against H9N2 AIV is highly ...

Gerlach T, Elbahesh H, Saletti G, Rimmelzwaan G. Recombinant influenza A viruses as vaccine vectors. Expert Rev Vaccines. 2019 Feb 19..  Abstract  
submitted by kickingbird at Feb, 21, 2019 from Expert Rev Vaccines. 2019 Feb 19. (via https://www.ncbi.nlm.nih.gov/pubmed/30777467)
Various viruses, including poxviruses, adenoviruses and vesicular stomatitis virus, have been considered as vaccine vectors for the delivery of antigens of interest in the development of vaccines against ...

Hu Y, et al. Immunogenicity and safety of a trivalent inactivated influenza vaccine produced in Shenzhen, China versus a comparator influenza vaccine: a phase IV randomized study. Hum Vaccin Immunother. 2019 Feb 19.  Abstract  
submitted by kickingbird at Feb, 21, 2019 from Hum Vaccin Immunother. 2019 Feb 19 (via https://www.ncbi.nlm.nih.gov/pubmed/30779689)
Seasonal influenza causes substantial morbidity and mortality in China, which largely results from limited vaccine accessibility and poor vaccination coverage. Since 2013, Sanofi Pasteur's facilities in ...

Byrne-Nash RT, et al. A neuraminidase potency assay for quantitative assessment of neuraminidase in influenza vaccines. NPJ Vaccines. 2019 Jan 22;4:3.  Abstract  
submitted by kickingbird at Jan, 26, 2019 from NPJ Vaccines. 2019 Jan 22;4:3 (via https://www.ncbi.nlm.nih.gov/pubmed/30675394)
Neuraminidase (NA) immunity leads to decreased viral shedding and reduced severity of influenza disease; however, NA content in influenza vaccines is currently not regulated, resulting in inconsistent ...

Yoo BW, Kim CO, Izu A, Arora AK, Heijnen E. Phase 4, Post-Marketing Safety Surveillance of the MF59-Adjuvanted Influenza Vaccines FLUAD? and VANTAFLU? in South Korean Subjects Aged ≥65 Years. Infect Chemother. 2018 Dec;50(4):301-310.  Abstract  
submitted by kickingbird at Jan, 7, 2019 from Infect Chemother. 2018 Dec;50(4):301-310 (via https://www.ncbi.nlm.nih.gov/pubmed/30600653)
BACKGROUD: Influenza vaccination is recommended for adults aged ≥65 years as they are at high risk of significant morbidity and mortality. This open-label, multicenter, post-marketing surveillance study ...

Job ER, et al. Broadened immunity against influenza by vaccination with computationally designed influenza virus N1 neuraminidase constructs. NPJ Vaccines. 2018 Nov 29;3:55.  Abstract  
submitted by kickingbird at Dec, 6, 2018 from NPJ Vaccines. 2018 Nov 29;3:55 (via https://www.ncbi.nlm.nih.gov/pubmed/30510776)
Split inactivated influenza vaccines remain one of the primary preventative strategies against severe influenza disease in the population. However, current vaccines are only effective against a limited ...

Souza CK, et al. Serological surveillance and factors associated with influenza A virus in backyard pigs in Southern Brazil. Zoonoses Public Health. 2018 Nov 28.  Abstract  
submitted by kickingbird at Dec, 4, 2018 from Zoonoses Public Health. 2018 Nov 28 (via https://www.ncbi.nlm.nih.gov/pubmed/30485723)
Backyard pig populations are not monitored for influenza A virus (IAV) in Brazil and there are limited data about seroprevalence and risk factors in these populations. Our goal was to assess possible factors ...

Bhardwaj J, Sharma A, Jang J. Vertical flow-based paper immunosensor for rapid electrochemical and colorimetric detection of influenza virus using a different pore size sample pad. Biosens Bioelectron. 2018 Oct 19;126:36-43.  Abstract  
submitted by kickingbird at Nov, 3, 2018 from Biosens Bioelectron. 2018 Oct 19;126:36-43 (via https://www.ncbi.nlm.nih.gov/pubmed/30388552)
We present a novel vertical flow-based paper immunosensor for the rapid and sensitive electrochemical and colorimetric detection of influenza H1N1 viruses using a different pore size (DP) sample pad. The ...

Hussain S, et al. Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine viruses. J Virol. 2018 Oct 31..  Abstract  
submitted by kickingbird at Nov, 3, 2018 from J Virol. 2018 Oct 31. (via https://www.ncbi.nlm.nih.gov/pubmed/30381488)
The PA-X protein of influenza A virus has roles in host cell shut-off and viral pathogenesis. While most strains are predicted to encode PA-X, strain-dependent variations in activity have been noted. We ...

van der Lubbe JEM, et al. Mini-HA Is Superior to Full Length Hemagglutinin Immunization in Inducing Stem-Specific Antibodies and Protection Against Group 1 Influenza Virus Challenges in Mice. Front Immunol. 2018 Oct 12;9:2350.  Abstract  
submitted by kickingbird at Oct, 31, 2018 from Front Immunol. 2018 Oct 12;9:2350 (via https://www.frontiersin.org/articles/10.3389/fimmu.2018.0235)
Seasonal influenza vaccines are updated almost annually to match the antigenic drift in influenza hemagglutinin (HA) surface glycoprotein. A new HA stem-based antigen, the so-called "mini-HA," was recently ...

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