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2021-6-19 3:08:03
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Yu Y, Wu M, Cui X, Xu F, Wen F, Pan L, Li S, Sun H. Pathogenicity and transmissibility of current H3N2 swine influenza virus in Southern China: A zoonotic potential. Transbound Emerg Dis. 2021 Jun 15.  Abstract  
submitted by kickingbird at 2 days ago from Transbound Emerg Dis. 2021 Jun 15 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14190)
Swine are considered as "mixing vessels" of influenza A viruses and play an important role in the generation of novel influenza pandemics. In this study, we described that the H3N2 swine influenza (swH3N2) ...

Blumenkrantz DR, Mehoke T, Shaw-Saliba K, Powell H. Identification of H3N2 NA and PB1-F2 genetic variants and their association with disease symptoms during the 2014-15 influenza season. Virus Evol. 2021 Jun 4;7(1):veab047.  Abstract  
submitted by kickingbird at 2 days ago from Virus Evol. 2021 Jun 4;7(1):veab047 (via https://academic.oup.com/ve/article/7/1/veab047/6272594)
The 2014-15 influenza season saw the emergence of an H3N2 antigenic drift variant that formed the 3C.2a HA clade. Whole viral genomes were sequenced from nasopharyngeal swabs of ninety-four patients with ...

Ghabeshi S, Ebrahimie E, Yavarian J, Salimi V, Sha. Molecular characterization of low pathogenic avian influenza H9N2 virus during co-circulation with newly-emerged highly pathogenic avian influenza H5N8 virus in Iran. Acta Virol. 2021;65(2):200-211.  Abstract  
submitted by kickingbird at 2 days ago from Acta Virol. 2021;65(2):200-211 (via https://pubmed.ncbi.nlm.nih.gov/34130471/)
Identification of molecular characteristics of low pathogenic avian influenza (LPAI) H9N2 virus provides insights into the evolution of this subtype due to the modulation of genomic characteristics in ...

Kwon JH, Lee DH, Criado MF, Killmaster L, Ali MZ,. Genetic evolution and transmission dynamics of clade 2.3.2.1a highly pathogenic avian influenza A/H5N1 viruses in Bangladesh. Virus Evol. 2020 Jun 13;6(2):veaa046.  Abstract  
submitted by kickingbird at 3 days ago from Virus Evol. 2020 Jun 13;6(2):veaa046 (via https://academic.oup.com/ve/article/6/2/veaa046/5857140)
Asian lineage A/H5N1 highly pathogenic avian influenza viruses (HPAIVs) have been responsible for continuous outbreaks in Bangladesh since 2007. Although clades 2.2.2 and 2.3.4.2 HPAIVs have disappeared ...

Zhao T, Asawa K, Masuda T, Honda A, Kushiro K, Cab. Fluorescent polymeric nanoparticle for ratiometric temperature sensing allows real-time monitoring in influenza virus-infected cells. J Colloid Interface Sci. 2021 Jun 1;601:825-832.  Abstract  
submitted by kickingbird at 4 days ago from J Colloid Interface Sci. 2021 Jun 1;601:825-832 (via https://www.sciencedirect.com/science/article/abs/pii/S00219)
Temperature is a key indicator of infection and disease, however, it is difficult to measure at a cellular level. Nanoparticles are applied to measure the cellular temperature, and enhancement of the stability ...

Xing L, Chen Y, Chen B, Bu L, Liu Y, Zeng Z, Guan. Antigenic Drift of the Hemagglutinin from an Influenza A (H1N1) pdm09 Clinical Isolate Increases its Pathogenicity In Vitro. Virol Sin. 2021 Jun 9:1–8. doi: 10.1007/s12250-021.  Abstract  
submitted by kickingbird at 7 days ago from Virol Sin. 2021 Jun 9:1–8. doi: 10.1007/s12250-021 (via https://link.springer.com/article/10.1007/s12250-021-00401-y)
The influenza A (H1N1) pdm09 virus emerged in 2009 and has been continuously circulating in humans for over ten years. Here, we analyzed a clinical influenza A (H1N1) pdm09-infected patient case hospitalized ...

Liu S, Mok BW, Deng S, Liu H, Wang P, Song W, Chen. Mammalian cells use the autophagy process to restrict avian influenza virus replication. Cell Rep. 2021 Jun 8;35(10):109213.  Abstract  
submitted by kickingbird at 7 days ago from Cell Rep. 2021 Jun 8;35(10):109213 (via https://www.cell.com/cell-reports/fulltext/S2211-1247(21)005)
Host adaptive mutations in the influenza A virus (IAV) PB2 protein are critical for human infection, but their molecular action is not well understood. We observe that when IAV containing avian PB2 infects ...

Criado MF, Moresco KA, Stallknecht DE, Swayne DE. Low-pathogenicity influenza viruses replicate differently in laughing gulls and mallards. Influenza Other Respir Viruses. 2021 Jun 10.  Abstract  
submitted by kickingbird at 7 days ago from Influenza Other Respir Viruses. 2021 Jun 10 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.12878)
Wild aquatic birds are natural reservoirs of low-pathogenicity avian influenza viruses (LPAIVs). Laughing gulls inoculated with four gull-origin LPAIVs (H7N3, H6N4, H3N8, and H2N3) had a predominate respiratory ...

Barnard KN, Wasik BR, Alford-Lawrence BK, Hayward. Sequence dynamics of three influenza A virus strains grown in different MDCK cell lines, including those expressing different sialic acid receptors. J Evol Biol. 2021 Jun 11.  Abstract  
submitted by kickingbird at 7 days ago from J Evol Biol. 2021 Jun 11 (via https://pubmed.ncbi.nlm.nih.gov/34114711/)
Viruses are often cultured in cell lines for research and vaccine development, and those often differ from the natural hosts or tissues. Cell lines can also differ in the presence of virus receptors, such ...

Ziebert F, Kuli? IM. How Influenza´s Spike Motor Works. Phys Rev Lett. 2021 May 28;126(21):218101.  Abstract  
submitted by kickingbird at 7 days ago from Phys Rev Lett. 2021 May 28;126(21):218101 (via https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.12)
While often believed to be a passive agent that merely exploits its host's metabolism, the influenza virus has recently been shown to actively move across glycan-coated surfaces. This form of enzymatically ...

Sasaki Y, Yoshino N, Okuwa T, Odagiri T, Satoh T,. A mouse monoclonal antibody against influenza C virus attenuates acetaminophen-induced liver injury in mice. Sci Rep. 2021 Jun 3;11(1):11816.  Abstract  
submitted by kickingbird at 12 days ago from Sci Rep. 2021 Jun 3;11(1):11816 (via https://www.nature.com/articles/s41598-021-91251-x)
Molecular mimicry is one of the main processes for producing autoantibodies during infections. Although some autoantibodies are associated with autoimmune diseases, the functions of many autoantibodies ...

Guthmiller JJ, Han J, Li L, Freyn AW, Liu STH, Sto. First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes. Sci Transl Med. 2021 Jun 2;13(596):eabg4535.  Abstract  
submitted by kickingbird at 15 days ago from Sci Transl Med. 2021 Jun 2;13(596):eabg4535 (via https://stm.sciencemag.org/content/13/596/eabg4535)
Broadly neutralizing antibodies are critical for protection against both drifted and shifted influenza viruses. Here, we reveal that first exposure to the 2009 pandemic H1N1 influenza virus recalls memory ...

McCarthy KR, Von Holle TA, Sutherland LL, Oguin TH. Differential immune imprinting by influenza virus vaccination and infection in nonhuman primates. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2026.  Abstract  
submitted by kickingbird at 15 days ago from Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2026 (via https://www.pnas.org/content/118/23/e2026752118)
Immune memory of a first infection with influenza virus establishes a lasting imprint. Recall of that memory dominates the response to later infections or vaccinations by antigenically drifted strains. ...

Elgendy EM, Arai Y, Kawashita N, Isobe A, Daidoji. Double mutations in the H9N2 avian influenza virus PB2 gene act cooperatively to increase viral host adaptation and replication for human infections. J Gen Virol. 2021 Jun;102(6).  Abstract  
submitted by kickingbird at Jun, 2, 2021 from J Gen Virol. 2021 Jun;102(6) (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Avian H9N2 influenza viruses in East Asia are genetically diversified and multiple genotypes (A-W) have been established in poultry. Genotype S strains are currently the most prevalent strains, have caused ...

Goldhill DH, Yan A, Frise R, Zhou J, Shelley J, Ga. Favipiravir-resistant influenza A virus shows potential for transmission. PLoS Pathog. 2021 Jun 1;17(6):e1008937.  Abstract  
submitted by kickingbird at Jun, 2, 2021 from PLoS Pathog. 2021 Jun 1;17(6):e1008937 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Favipiravir is a nucleoside analogue which has been licensed to treat influenza in the event of a new pandemic. We previously described a favipiravir resistant influenza A virus generated by in vitro passage ...

Wang Z, Yu J, Sheng Z, Hause BM, Li F, Kaushik RS,. Functional study of a role of N-terminal HA stem region of swine influenza A virus in virus replication. Vet Microbiol. 2021 May 25;258:109132.  Abstract  
submitted by kickingbird at May, 31, 2021 from Vet Microbiol. 2021 May 25;258:109132 (via https://www.sciencedirect.com/science/article/pii/S037811352)
Swine influenza A virus (SIV) is both a pathogen of economic significance to the swine industry and a potential zoonotic organism that may be transmitted to humans. We described here the detailed characterization ...

Chepkwony S, Parys A, Vandoorn E, Stadejek W, Xie. Genetic and antigenic evolution of H1 swine influenza A viruses isolated in Belgium and the Netherlands from 2014 through 2019. Sci Rep. 2021 May 28;11(1):11276.  Abstract  
submitted by kickingbird at May, 31, 2021 from Sci Rep. 2021 May 28;11(1):11276 (via https://www.nature.com/articles/s41598-021-90512-z)
Surveillance of swine influenza A viruses (swIAV) allows timely detection and identification of new variants with potential zoonotic risks. In this study, we aimed to identify swIAV subtypes that circulated ...

Sia ZR, He X, Zhang A, Ang JC, Shao S, Seffouh A,. A liposome-displayed hemagglutinin vaccine platform protects mice and ferrets from heterologous influenza virus challenge. Proc Natl Acad Sci U S A. 2021 Jun 1;118(22):e2025.  Abstract  
submitted by kickingbird at May, 31, 2021 from Proc Natl Acad Sci U S A. 2021 Jun 1;118(22):e2025 (via https://www.pnas.org/content/118/22/e2025759118)
Recombinant influenza virus vaccines based on hemagglutinin (HA) hold the potential to accelerate production timelines and improve efficacy relative to traditional egg-based platforms. Here, we assess ...

Wen F, Yang J, Guo J, Wang C, Cheng Q, Tang Z, Luo. Genetic characterization of an H5N6 avian influenza virus with multiple origins from a chicken in southern China, October 2019. BMC Vet Res. 2021 May 28;17(1):200.  Abstract  
submitted by kickingbird at May, 31, 2021 from BMC Vet Res. 2021 May 28;17(1):200 (via https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-)
Background: Highly pathogenic avian influenza viruses (HPAIVs) of H5 subtype pose a great threat to the poultry industry and human health. In recent years, H5N6 subtype has rapidly replaced H5N1 as the ...

Yang J, Huang M, Qiao S, Zhang P, Teng Q, Li X, Li. Replication and virulence of chimeric bat influenza viruses in mammalian and avian cells and in mice. Microb Pathog. 2021 May 24:104992.  Abstract  
submitted by kickingbird at May, 31, 2021 from Microb Pathog. 2021 May 24:104992 (via https://www.sciencedirect.com/science/article/abs/pii/S08824)
Previous studies have shown that chimeric bat influenza viruses can be generated by reverse genetic system. However, the roles of the surface or internal genes of chimeric bat influenza viruses in viral ...

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