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2021-10-18 16:43:11
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Kombiah S, Kumar M, Murugkar HV, Nagarajan S, Tosh. Role of expression of host cytokines in the pathogenesis of H9N2-PB2 reassortant and non-reassortant H5N1 avian influenza viruses isolated from crows in BALB/c mice. Microb Pathog. 2021 Oct 11:105239.  Abstract  
submitted by kickingbird at 2 days ago from Microb Pathog. 2021 Oct 11:105239 (via https://www.sciencedirect.com/science/article/abs/pii/S08824)
The present experiment was conducted to study the role of cytokine, chemokine and TLRs responses of H9N2-PB2 reassortant H5N1 viruses as compared to non-reassortant H5N1 viruses isolated from crows in ...

Wang F, Wan Z, Wu J, Wang Y, Fu H, Shao H, Qian K,. A Cross-Reactive Monoclonal Antibody Against Neuraminidases of Both H9N2 and H3N2 Influenza Viruses Shows Protection in Mice Challenging Models. Front Microbiol. 2021 Sep 27;12:730449.  Abstract  
submitted by kickingbird at 2 days ago from Front Microbiol. 2021 Sep 27;12:730449 (via https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503672/)
Neuraminidases (NAs) of H9N2 avian influenza virus (AIV) and H3N2 human seasonal influenza virus (HSIV) share similar antigenic structures. However, there are few reports on epitopes shared by these two ...

Shibuya M, Tamiya S, Kawai A, Hirai T, Cragg MS, Y. Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza. iScience. 2021 Sep 15;24(10):103131.  Abstract  
submitted by kickingbird at 6 days ago from iScience. 2021 Sep 15;24(10):103131 (via https://www.cell.com/iscience/fulltext/S2589-0042(21)01099-3)
Current influenza vaccines do not typically confer cross-protection against antigenically mismatched strains. To develop vaccines conferring broader cross-protection, recent evidence indicates the crucial ...

Charman M, McFarlane S, Wojtus JK, Sloan E, Dewar. Constitutive TRIM22 Expression in the Respiratory Tract Confers a Pre-Existing Defence Against Influenza A Virus Infection. Front Cell Infect Microbiol. 2021 Sep 21;11:689707.  Abstract  
submitted by kickingbird at 6 days ago from Front Cell Infect Microbiol. 2021 Sep 21;11:689707 (via https://www.frontiersin.org/articles/10.3389/fcimb.2021.6897)
The induction of antiviral effector proteins as part of a homeostatically controlled innate immune response to infection plays a critical role in limiting the propagation and transmission of respiratory ...

Jia R, Jiang C, Li L, Huang C, Lu L, Xu M, Xu J, L. Interleukin 16 Enhances the Host Susceptibility to Influenza A Virus Infection. Front Microbiol. 2021 Sep 22;12:736449.  Abstract  
submitted by kickingbird at 6 days ago from Front Microbiol. 2021 Sep 22;12:736449 (via https://www.frontiersin.org/articles/10.3389/fmicb.2021.7364)
Influenza A virus (IAV) is a major respiratory pathogen that causes seasonal and pandemic flu, being a threat to global health. Various viral and cellular factors have been characterized to support or ...

AboElkhair MA, Hasan ME, Mousa A, Moharam I, Sulta. In-silico evidence for enhancement of avian influenza virus H9N2 virulence by modulation of its hemagglutinin (HA) antigen function and stability during co-infection with infectious bronchitis virus i. Virusdisease. 2021 Sep;32(3):548-558.  Abstract  
submitted by kickingbird at 6 days ago from Virusdisease. 2021 Sep;32(3):548-558 (via https://link.springer.com/article/10.1007%2Fs13337-021-00688)
In the last few decades, frequent incidences of avian influenza (AI) H9N2 outbreaks have caused high mortality in poultry farms resulting in colossal economic losses in several countries. In Egypt, the ...

Waters K, Gao C, Ykema M, Han L, Voth L, Tao YJ, W. Triple reassortment increases compatibility among viral ribonucleoprotein genes of contemporary avian and human influenza A viruses. PLoS Pathog. 2021 Oct 7;17(10):e1009962.  Abstract  
submitted by kickingbird at 7 days ago from PLoS Pathog. 2021 Oct 7;17(10):e1009962 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Compatibility among the influenza A virus (IAV) ribonucleoprotein (RNP) genes affects viral replication efficiency and can limit the emergence of novel reassortants, including those with potential pandemic ...

Cui H, de Jong MC, Beerens N, van Oers MM, Teng Q,. Vaccination with inactivated virus against low pathogenic avian influenza subtype H9N2 does not prevent virus transmission in chickens. J Virus Erad. 2021 Sep 22;7(3):100055.  Abstract  
submitted by kickingbird at 7 days ago from J Virus Erad. 2021 Sep 22;7(3):100055 (via https://www.sciencedirect.com/science/article/pii/S205566402)
H9N2 subtype avian influenza has spread dramatically in China ever since first reported in the 1990s. A national vaccination program for poultry was initiated in 1998. Field isolation data show that the ...

Wang MH, Lou J, Cao L, Zhao S, Chan RW, Chan PK, C. Characterization of key amino acid substitutions and dynamics of the influenza virus H3N2 hemagglutinin. J Infect. 2021 Oct 7:S0163-4453(21)00498-9.  Abstract  
submitted by kickingbird at 7 days ago from J Infect. 2021 Oct 7:S0163-4453(21)00498-9 (via https://www.journalofinfection.com/article/S0163-4453(21)004)
The annual epidemics of seasonal influenza is partly attributed to the continued virus evolution. It is challenging to evaluate the effect of influenza virus mutations on evading population immunity. In ...

Chauhan RP, Gordon ML. Deciphering transmission dynamics and spillover of avian influenza viruses from avian species to swine populations globally. Virus Genes. 2021 Oct 8:1–15.  Abstract  
submitted by kickingbird at 7 days ago from Virus Genes. 2021 Oct 8:1–15 (via https://link.springer.com/article/10.1007%2Fs11262-021-01873)
Genome sequences of eleven avian influenza virus (AIV) subtypes have been reported in swine populations from seven countries until August 2020. To unravel the transmission dynamics and spillover events ...

Bessière P, Figueroa T, Coggon A, Foret-Lucas C, H. Opposite outcomes of the within-host competition between highly and low pathogenic H5N8 avian influenza viruses in chickens compared to ducks. J Virol. 2021 Oct 6:JVI0136621.  Abstract  
submitted by kickingbird at 11 days ago from J Virol. 2021 Oct 6:JVI0136621 (via https://journals.asm.org/doi/10.1128/JVI.01366-21)
Highly pathogenic avian influenza viruses (HPAIV) emerge from low pathogenic avian influenza viruses (LPAIV) through the introduction of basic amino acids at the hemagglutinin (HA) cleavage site. Following ...

Gao J, Klenow L, Parsons L, Malik T, Phue JN, Gao. Design of the Recombinant Influenza Neuraminidase Antigen is Crucial for its Biochemical Properties and Protective Efficacy. J Virol. 2021 Oct 6:JVI0116021.  Abstract  
submitted by kickingbird at 11 days ago from J Virol. 2021 Oct 6:JVI0116021 (via https://journals.asm.org/doi/10.1128/JVI.01160-21)
Supplementing influenza vaccines with recombinant neuraminidase (rNA) antigens remains a promising approach for improving the suboptimal vaccine efficacy. However, correlations among rNA designs, properties, ...

Hossain MG, Akter S, Dhole P, Saha S, Kazi T, Majb. Analysis of the Genetic Diversity Associated With the Drug Resistance and Pathogenicity of Influenza A Virus Isolated in Bangladesh From 2002 to 2019. Front Microbiol. 2021 Sep 17;12:735305..  Abstract  
submitted by kickingbird at 12 days ago from Front Microbiol. 2021 Sep 17;12:735305. (via https://www.frontiersin.org/articles/10.3389/fmicb.2021.7353)
The subtype prevalence, drug resistance- and pathogenicity-associated mutations, and the distribution of the influenza A virus (IAV) isolates identified in Bangladesh from 2002 to 2019 were analyzed using ...

Klivleyeva NG, Ongarbayeva NS, Korotetskiy IS, Gle. Coding-Complete Genome Sequence of Swine Influenza Virus Isolate A/Swine/Karaganda/04/2020 (H1N1) from Kazakhstan. Microbiol Resour Announc. 2021 Sep 30;10(39):e0078.  Abstract  
submitted by kickingbird at 15 days ago from Microbiol Resour Announc. 2021 Sep 30;10(39):e0078 (via https://journals.asm.org/doi/10.1128/MRA.00786-21)
Here, we report the coding-complete genome sequence of a clinical sample of influenza virus obtained from a pig at a livestock farm in Karaganda, Central Kazakhstan, during a pig study in 2020. Isolate ...

Wan Z, Kan Q, Zhao Z, Shao H, Deliberto TJ, Wan XF. Characterization of Subtype H6 Avian Influenza A Viruses Isolated From Wild Birds in Poyang Lake, China. Front Vet Sci. 2021 Sep 13;8:685399.  Abstract  
submitted by kickingbird at 15 days ago from Front Vet Sci. 2021 Sep 13;8:685399 (via https://www.frontiersin.org/articles/10.3389/fvets.2021.6853)
Subtype H6 avian influenza A viruses (IAVs) are enzootic and genetically diverse in both domestic poultry and wild waterfowl and may cause spillovers in both pigs and humans. Thus, it is important to understand ...

Hussain S, Daniels RS, Wharton SA, Howell S, Halai. Reduced sialidase activity of influenza A(H3N2) neuraminidase associated with positively charged amino acid substitutions. J Gen Virol. 2021 Oct;102(10).  Abstract  
submitted by kickingbird at 15 days ago from J Gen Virol. 2021 Oct;102(10) (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Neuraminidase (NA) inhibitors (NAI), oseltamivir and zanamivir, are the main antiviral medications for influenza and monitoring of susceptibility to these antivirals is routinely done by determining 50 ...

Li YT, Su YCF, Smith GJD. H5Nx Viruses Emerged during the Suppression of H5N1 Virus Populations in Poultry. Microbiol Spectr. 2021 Sep 29:e0130921.  Abstract  
submitted by kickingbird at Sep, 30, 2021 from Microbiol Spectr. 2021 Sep 29:e0130921 (via https://journals.asm.org/doi/10.1128/Spectrum.01309-21)
Highly pathogenic avian influenza (HPAI) H5 viruses have posed a substantial pandemic threat through repeated human infection since their emergence in China in 1996. Nationwide control measures, including ...

Sun Z, Wang Q, Li G, Li J, Chen S, Qin T, Ma H, Pe. Development of an Inactivated H7N9 Subtype Avian Influenza Serological DIVA Vaccine Using the Chimeric HA Epitope Approach. Microbiol Spectr. 2021 Sep 29:e0068721.  Abstract  
submitted by kickingbird at Sep, 30, 2021 from Microbiol Spectr. 2021 Sep 29:e0068721 (via https://journals.asm.org/doi/10.1128/Spectrum.00687-21)
H7N9 avian influenza virus (AIV) is an emerging zoonotic pathogen, and it is necessary to develop a differentiating infected from vaccinated animals (DIVA) vaccine for the purpose of eradication. H7N9 ...

Nogales A, Villamayor L, Utrilla-Trigo S, Ortego J. Natural Selection of H5N1 Avian Influenza A Viruses with Increased PA-X and NS1 Shutoff Activity. Viruses. 2021 Sep 3;13(9):1760.  Abstract  
submitted by kickingbird at Sep, 29, 2021 from Viruses. 2021 Sep 3;13(9):1760 (via https://www.mdpi.com/1999-4915/13/9/1760)
Influenza A viruses (IAV) can infect a broad range of mammalian and avian species. However, the host innate immune system provides defenses that restrict IAV replication and infection. Likewise, IAV have ...

Sanogo IN, Kouakou C, Batawui K, Djegui F, Byaruga. Serological Surveillance of Influenza D Virus in Ruminants and Swine in West and East Africa, 2017-2020. Viruses. 2021 Sep 2;13(9):1749.  Abstract  
submitted by kickingbird at Sep, 29, 2021 from Viruses. 2021 Sep 2;13(9):1749 (via https://www.mdpi.com/1999-4915/13/9/1749)
Influenza D virus (IDV) was first isolated in 2011 in Oklahoma, USA from pigs presenting with influenza-like symptoms. IDV is known to mainly circulate in ruminants, especially cattle. In Africa, there ...

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