Ishiguro N. et al. Clinical effectiveness of four neuraminidase inhibitors(oseltamivir, zanamivir, laninamivir,and peramivir) for children with influenza A and B in the 2014-2015 to 2016-2017 influenza seasons in Japan. J Infect Chemother. 2018 Feb 24. Abstract
submitted by kickingbird at 2 hours ago from J Infect Chemother. 2018 Feb 24 (via https://www.ncbi.nlm.nih.gov/pubmed/29487035)
The clinical effectiveness of four neuraminidase inhibitors (NAIs) (oseltamivir, zanamivir, laninamivir, and peramivir) for children aged 0 months to 18 years with influenza A and B were investigated in ...
Lee IW, etc.,al. Comparison of the virulence and transmissibility of canine H3N2 influenza viruses and characterization of their canine adaptation factors. Emerg Microbes Infect. 2018 Mar 7;7(1):17. Abstract
submitted by kickingbird at 8 days ago from Emerg Microbes Infect. 2018 Mar 7;7(1):17 (via https://www.ncbi.nlm.nih.gov/pubmed/29511200)
Recent canine influenza outbreaks have raised concerns about the generation of pathogenic variants that may pose a threat to public health. Here, we examine avian-like H3N2 canine influenza viruses (CIVs) ...
Jin H, etc.,al. Evolution of H9N2 avian influenza virus in embryonated chicken eggs with or without homologous vaccine antibodies. BMC Vet Res. 2018 Mar 6;14(1):71.. Abstract
submitted by kickingbird at 8 days ago from BMC Vet Res. 2018 Mar 6;14(1):71. (via https://www.ncbi.nlm.nih.gov/pubmed/29510698)
BACKGROUND: Vaccines constitute a unique selective pressure, different from natural selection, drives the evolution of influenza virus. In this study, A/Chicken/Shanghai/F/1998 (H9N2) was continually passaged ...
Czako R, Vogel L, Sutton T, Matsuoka Y, et al. H5N2 vaccine viruses on Russian and US live attenuated influenza virus backbones demonstrate similar infectivity, immunogenicity and protection in ferrets. Vaccine 2018 Mar 1.. Abstract
submitted by kickingbird at 8 days ago from Vaccine 2018 Mar 1. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29503113/)
The continued detection of zoonotic influenza infections, most notably due to the avian influenza A H5N1 and H7N9 subtypes, underscores the need for pandemic preparedness. Decades of experience with live ...
Tinoco R, Carrette F, Henriquez ML, Fujita Y, et a. Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4+ T Cells. J Immunol 2018 Feb 28. Abstract
submitted by kickingbird at 8 days ago from J Immunol 2018 Feb 28 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29491007/)
T cells mediating influenza viral control are instructed in lymphoid and nonlymphoid tissues to differentiate into memory T cells that confer protective immunity. The mechanisms by which influenza virus-specific ...
Kwon JJ, Choi WS, Jeong JH, Kim EH, et al. An I436N substitution confers resistance of influenza A(H1N1)pdm09 viruses to multiple neuraminidase inhibitors without affecting viral fitness. J Gen Virol 2018;99:292-302. Abstract
submitted by kickingbird at 8 days ago from J Gen Virol 2018;99:292-302 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29493493/)
The resistance of influenza viruses to neuraminidase (NA) inhibitors (NAIs; i.e. oseltamivir, zanamivir, peramivir and laninamivir) can be associated with several NA substitutions, with differing effects ...
Takizawa N, Kimura T, Watanabe T, Shibasaki M, et. Anti-influenza virus activity of a salcomine derivative mediated by inhibition of viral RNA synthesis. Arch Virol 2018 Mar 1. Abstract
submitted by kickingbird at 8 days ago from Arch Virol 2018 Mar 1 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29497849/)
Influenza virus infection is a major threat to global health. Although vaccines and anti-influenza virus drugs are available, annual influenza virus epidemics result in severe illness, and an influenza ...
Musharrafieh R, Ma C, Wang J. Profiling the in vitro drug-resistance mechanism of influenza A viruses towards the AM2-S31N proton channel blockers. Antiviral Res 2018 Mar 5.. Abstract
submitted by kickingbird at 8 days ago from Antiviral Res 2018 Mar 5. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29518414/)
The majority of human influenza A viruses currently in circulation carry the amantadine-resistant AM2-S31N channel mutation. We previously discovered a series of AM2-S31N inhibitors with potent antiviral ...
Shirin Hosseini, Esther Wilk, Kristin Michaelsen-P. Long-term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function. Journal of Neuroscience 27 February 2018. Abstract
submitted by kickingbird at Mar, 1, 2018 from Journal of Neuroscience 27 February 2018 (via http://www.jneurosci.org/content/early/2018/02/28/JNEUROSCI.)
Acute influenza infection has been reported to be associated with neurological symptoms. However, the long-term consequences for the CNS of an infection with neurotropic but also with non-neurotropic influenza ...
Scoizec A, Niqueux E, Thomas R, Daniel P, Schmitz. Airborne Detection of H5N8 Highly Pathogenic Avian Influenza Virus Genome in Poultry Farms, France. Front. Vet. Sci., 13 February 2018. Abstract
submitted by kickingbird at Mar, 1, 2018 from Front. Vet. Sci., 13 February 2018 (via https://www.frontiersin.org/articles/10.3389/fvets.2018.0001)
In southwestern France, during the winter of 2016–2017, the rapid spread of highly pathogenic avian influenza H5N8 outbreaks despite the implementation of routine control measures, raised the question ...
Dan Xiang,etc.,al. Convergent Evolution of Human-Isolated H7N9 Avian Influenza A Viruses. The Journal of Infectious Diseases 09 Feb 2018. Abstract
submitted by kickingbird at Mar, 1, 2018 from The Journal of Infectious Diseases 09 Feb 2018 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
BackgroundAvian influenza A virus (AIV) H7N9 has caused five epidemic waves of human infections in China since 2013. AIVs may face strong selection to adapt to novel conditions when establishing themselves ...
Salaheldin HA, Abd El-Hamid HS, Elbestawy AR, Veit. Multiple Introductions of Influenza A(H5N8) Virus into Poultry, Egypt, 2017. Emerg Infect Dis. 2018 May. Abstract
submitted by kickingbird at Mar, 1, 2018 from Emerg Infect Dis. 2018 May (via https://wwwnc.cdc.gov/eid/article/24/5/17-1935_article)
After high mortality rates among commercial poultry were reported in Egypt in 2017, we genetically characterized 4 distinct influenza A(H5N8) viruses isolated from poultry. Full-genome analysis indicated ...
Ma M-J, Liu C, Wu M-N, Zhao T, Wang G-L, Yang Y, e. Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017. Emerg Infect Dis. 2018 Apr. Abstract
submitted by kickingbird at Mar, 1, 2018 from Emerg Infect Dis. 2018 Apr (via https://wwwnc.cdc.gov/eid/article/24/4/17-1995_article)
Avian influenza A(H7N9) virus has caused 5 epidemic waves in China since its emergence in 2013. We investigated the dynamic changes of antibody response to this virus over 1 year postinfection in 25 patients ...
Yamayoshi S, Kiso M, Yasuhara A, Ito M, Shu Y, Kaw. Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans. Emerg Infect Dis. 2018 Apr. Abstract
submitted by kickingbird at Mar, 1, 2018 from Emerg Infect Dis. 2018 Apr (via https://wwwnc.cdc.gov/eid/article/24/4/17-1509_article)
To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2–482R, polymerase basic 2–588V, ...
Jie Zhou,etc.,al. Defining the sizes of airborne particles that mediate influenza transmission in ferrets. PNAS 2018; published ahead of print February 20, 2. Abstract
submitted by kickingbird at Feb, 23, 2018 from PNAS 2018; published ahead of print February 20, 2 (via http://www.pnas.org/content/early/2018/02/13/1716771115)
SignificanceEmerging respiratory pathogens pose significant public health threats as a result of their potential for rapid global spread via multiple non-mutually exclusive modes of transmission. The relative ...
H. Nedland, etc.,al. Serological evidence for the co-circulation of two lineages of influenza D viruses in equine populations of the Midwest United States. Zoonoses Public Health,2018 Feb 1. Abstract
submitted by kickingbird at Feb, 19, 2018 from Zoonoses Public Health,2018 Feb 1 (via https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766371/)
Influenza D virus (IDV) is a newly described influenza type of the Orthomyxoviridae virus family that was first isolated from diseased swine in 2011 and has subsequently been detected in cattle around ...
Xiang D, Shen X, Pu Z, Irwin DM, et al. Convergent Evolution of Human-Isolated H7N9 Avian Influenza A Viruses. J Infect Dis 2018 Feb 9. Abstract
submitted by kickingbird at Feb, 19, 2018 from J Infect Dis 2018 Feb 9 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29438519/)
Background: Avian influenza A virus (AIV) H7N9 has caused five epidemic waves of human infections in China since 2013. AIVs may face strong selection to adapt to novel conditions when establishing themselves ...
Anderson AM, Baranowska-Hustad M, Braathen R, Grod. Simultaneous Targeting of Multiple Hemagglutinins to APCs for Induction of Broad Immunity against Influenza. J Immunol 2018 Feb 2. Abstract
submitted by kickingbird at Feb, 19, 2018 from J Immunol 2018 Feb 2 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29427414/)
There is a need for vaccines that can confer broad immunity against highly diverse pathogens, such as influenza. The efficacy of conventional influenza vaccines is dependent on accurate matching of vaccines ...
Coates BM, Staricha KL, Koch CM, Cheng Y, et al. Inflammatory Monocytes Drive Influenza A Virus-Mediated Lung Injury in Juvenile Mice. Immunol 2018 Feb 14. Abstract
submitted by kickingbird at Feb, 19, 2018 from Immunol 2018 Feb 14 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29445006/)
Healthy children are more likely to die of influenza A virus (IAV) infection than healthy adults. However, little is known about the mechanisms underlying the impact of young age on the development of ...
White KM, Ayllon J, Mena I, Potenski A, et al. Influenza B virus reverse genetic backbones with improved growth properties in the EB66 cell line as basis for vaccine seed virus generation. Vaccine 2018;36:1146-1153. Abstract
submitted by kickingbird at Feb, 11, 2018 from Vaccine 2018;36:1146-1153 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29395518/)
Vaccination remains the best available prophylaxis to prevent influenza virus infections, yet current inadequacies in influenza virus vaccine manufacturing often lead to vaccine shortages at times when ...
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