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2019-9-17 17:24:00
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Wang W, et al. Generation of a protective murine monoclonal antibody against the stem of influenza hemagglutinins from group 1 viruses and identification of resistance mutations against it. PLoS One. 2019 Sep 12;14(9):e0222436..  Abstract  
submitted by kickingbird at 3 days ago from PLoS One. 2019 Sep 12;14(9):e0222436. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Vaccines that elicit broadly cross-neutralizing antibodies, including antibodies that target the conserved stem of hemagglutinin (HA), are being developed as a strategy for next-generation influenza vaccines ...

Wasik BR, et al. Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation. J Virol. 2019 Sep 11.  Abstract  
submitted by kickingbird at 3 days ago from J Virol. 2019 Sep 11 (via https://jvi.asm.org/content/early/2019/09/06/JVI.01039-19)
Influenza A viruses have regularly jumped to new host species to cause epidemics or pandemics, an evolutionary process that involves variation in the viral traits necessary to overcome host barriers and ...

Kim CW, Yoo HJ, Park JH, Oh JE, Lee HK. Exogenous Interleukin-33 Contributes to Protective Immunity via Cytotoxic T-Cell Priming against Mucosal Influenza Viral Infection. Viruses. 2019 Sep 10;11(9)..  Abstract  
submitted by kickingbird at 3 days ago from Viruses. 2019 Sep 10;11(9). (via https://www.mdpi.com/1999-4915/11/9/840)
Influenza is an infectious respiratory illness caused by the influenza virus. Though vaccines against influenza exist, they have limited efficacy. To additionally develop effective treatments, there is ...

Yao L, et al. Identification of antigenic epitopes in the hemagglutinin protein of H7 avian influenza virus. Avian Pathol. 2019 Sep 11.  Abstract  
submitted by kickingbird at 3 days ago from Avian Pathol. 2019 Sep 11 (via https://www.tandfonline.com/doi/abs/10.1080/03079457.2019.16)
The H7 subtype avian influenza virus (AIV) has been reported to infect not only poultry but also humans. The hemagglutinin (HA) protein is the major surface antigen of AIV and plays an important role in ...

Daikoku T, et al. Growth activation of influenza virus by trypsin and effect of T-705 (favipiravir) on trypsin-optimized growth condition. Acta Virol. 2019;63(3):309-315.  Abstract  
submitted by kickingbird at 3 days ago from Acta Virol. 2019;63(3):309-315 (via http://www.elis.sk/index.php?page=shop.product_details&flypa)
Influenza virus is activated by proteolytic cleavage of hemagglutinin by trypsin. After determining the optimal trypsin concentration, intracellular and extracellular influenza A/PR/8/34 (H1N1) and A/Victoria/361/2011 ...

Bai N, Zhang J, Li L, Jin Z. Evaluating the effect of virus mutation on the transmission of avian influenza H7N9 virus in China based on dynamical model. Math Biosci Eng. 2019 Apr 18;16(5):3393-3410..  Abstract  
submitted by kickingbird at 5 days ago from Math Biosci Eng. 2019 Apr 18;16(5):3393-3410. (via https://www.aimspress.com/article/10.3934/mbe.2019170)
In 2017, the low pathogenic avian influenza H7N9 virus in China had mutated into high pathogenicity to domestic poultry, and led to a large number of poultry death and human cases. To evaluate the effect ...

Saucedo O, Martcheva M, Annor A. Computing human to human Avian influenza R0 via transmission chains and parameter estimation. Math Biosci Eng. 2019 Apr 19;16(5):3465-3487..  Abstract  
submitted by kickingbird at 5 days ago from Math Biosci Eng. 2019 Apr 19;16(5):3465-3487. (via https://www.aimspress.com/article/10.3934/mbe.2019174)
The transmission of avian influenza between humans is extremely rare, and it mostly affects individuals who are in contact with infected family member. Although this scenario is uncommon, there have been ...

A Andrews M, T Bauch C. Parameterizing a dynamic influenza model using longitudinal versus age-stratified case notifications yields different predictions of vaccine impacts. Math Biosci Eng. 2019 Apr 29;16(5):3753-3770..  Abstract  
submitted by kickingbird at 5 days ago from Math Biosci Eng. 2019 Apr 29;16(5):3753-3770. (via https://www.aimspress.com/article/10.3934/mbe.2019186)
Dynamic transmission models of influenza are sometimes used in decision-making to identify which vaccination strategies might best reduce influenza-associated health burdens. Our goal was to use laboratory ...

Dreier C, et al. Mutations in the H7 HA and PB1 genes of avian influenza a viruses increase viral pathogenicity and contact transmission in guinea pigs. Emerg Microbes Infect. 2019;8(1):1324-1336..  Abstract  
submitted by kickingbird at 5 days ago from Emerg Microbes Infect. 2019;8(1):1324-1336. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Avian influenza A viruses (AIV) of the H7 subtype continue to evolve posing a pandemic threat. However, molecular markers of H7N7 AIV pathogenicity and transmission in mammals remain poorly understood. ...

Zhang S, et al. Influenza A virus infection induces liver injury in mice. Microb Pathog.2019 Sep 7:103736..  Abstract  
submitted by kickingbird at 5 days ago from Microb Pathog.2019 Sep 7:103736. (via https://www.sciencedirect.com/science/article/pii/S088240101)
Respiratory infections such as SARS-CoV in humans are often accompanied by mild and self-limiting hepatitis. As a respiratory disease, influenza A virus (IAV) infection can lead to hepatitis, but the mechanism ...

Guan L, et al. H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets. Emerg Microbes Infect. 2019;8(1):1280-1290.  Abstract  
submitted by kickingbird at 6 days ago from Emerg Microbes Infect. 2019;8(1):1280-1290 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
The H3N2 influenza viruses became widespread in humans during the 1968 H3N2 pandemic and have been a major cause of influenza epidemics ever since. Different lineages of H3N2 influenza viruses are also ...

Liu R, et al. Genetic and antigenic characteristics of a human influenza C virus clinical isolate. J Med Virol. 2019 Sep 9.  Abstract  
submitted by kickingbird at 6 days ago from J Med Virol. 2019 Sep 9 (via https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25589)
Unlike influenza A and B viruses that infect humans and cause severe diseases in seasonal epidemics, influenza C virus (ICV) is a ubiquitous childhood pathogen typically causing mild respiratory symptoms. ...

Leyson C, et al. Pathogenicity and genomic changes of a 2016 European H5N8 highly pathogenic avian influenza virus (clade 2.3.4.4) in experimentally infected mallards and chickens. Virology. 2019 Aug 22;537:172-185.  Abstract  
submitted by kickingbird at 8 days ago from Virology. 2019 Aug 22;537:172-185 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Highly pathogenic avian influenza H5N8 clade 2.3.4.4 virus caused outbreaks in poultry and unusually high mortality in wild birds in 2016-2017. The pathobiology of one of these viruses was examined in ...

Zhang S, et al. p-STAT1 regulates the influenza A virus replication and inflammatory response in vitro and vivo. Virology. 2019 Aug 25;537:110-120.  Abstract  
submitted by kickingbird at 8 days ago from Virology. 2019 Aug 25;537:110-120 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
nfluenza A virus infection activates various intracellular signaling pathways, which is mediated by the transcription factors. Here, a quantitative phosphoproteomic analysis of A549?cells after infection ...

Jansen JM, et al. Influenza virus-specific CD4+ and CD8+ T cell-mediated immunity induced by infection and vaccination. J Clin Virol. 2019 Aug 24;119:44-52.  Abstract  
submitted by kickingbird at 8 days ago from J Clin Virol. 2019 Aug 24;119:44-52 (via https://www.ncbi.nlm.nih.gov/pubmed/31491709)
Influenza A and B virus infections are a major cause of respiratory disease in humans and are responsible for substantial morbidity and mortality worldwide. Vaccination against influenza mainly aims at ...

Zhang T, et al. First Detection of a Novel Reassortant Avian Influenza A(H5N6) Clade 2.3.2.1c Virus, Isolated from a Wild Bird in China. Microbiol Resour Announc. 2019 Sep 5;8(36).  Abstract  
submitted by kickingbird at 8 days ago from Microbiol Resour Announc. 2019 Sep 5;8(36) (via https://mra.asm.org/content/8/36/e00797-19)
We report the first isolation of a reassortant clade 2.3.2.1c avian influenza A(H5N6) virus isolated from a wild bird sample in Jiangxi, China, in 2016. Sequence analyses indicated that this virus most ...

Zak AJ, Hill BD, Rizvi SM, Smith MR, Yang M, Wen F. Enhancing the Yield and Quality of Influenza Virus-like Particles (VLPs) Produced in Insect Cells by Inhibiting Cytopathic Effects of Matrix Protein M2. ACS Synth Biol. 2019 Sep 5..  Abstract  
submitted by kickingbird at 8 days ago from ACS Synth Biol. 2019 Sep 5. (via https://pubs.acs.org/doi/10.1021/acssynbio.9b00111)
To provide broader protection and eliminate the need for annual update of influenza vaccines, biomolecular engineering of influenza virus-like particles (VLPs) to display more conserved influenza proteins ...

Fan H, et al. Structures of influenza A virus RNA polymerase offer insight into viral genome replication. Nature. 2019 Sep 4..  Abstract  
submitted by kickingbird at 8 days ago from Nature. 2019 Sep 4. (via https://www.nature.com/articles/s41586-019-1530-7)
Influenza A viruses are responsible for seasonal epidemics, and pandemics can arise from the transmission of novel zoonotic influenza A viruses to humans1,2. Influenza A viruses contain a segmented negative-sense ...

Li J, et al. Amino acid substitutions in antigenic region B of hemagglutinin play a critical role in the antigenic drift of subclade 2.3.4.4 highly pathogenic H5NX influenza viruses. Transbound Emerg Dis. 2019 Sep 4..  Abstract  
submitted by kickingbird at 8 days ago from Transbound Emerg Dis. 2019 Sep 4. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13347)
As one of the important control strategies for highly pathogenic avian influenza (HPAI) in China, vaccination has been implemented compulsively in poultry flocks since 2004. However, the emergence and ...

Germeraad EA1, et al. Virus Shedding of Avian Influenza in Poultry: A Systematic Review and Meta-Analysis. Viruses. 2019 Sep 2;11(9).  Abstract  
submitted by kickingbird at 8 days ago from Viruses. 2019 Sep 2;11(9) (via https://www.mdpi.com/1999-4915/11/9/812)
Understanding virus shedding patterns of avian influenza virus (AIV) in poultry is important for understanding host-pathogen interactions and developing effective control strategies. Many AIV strains were ...

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