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2021-3-8 2:30:34

Na EJ, Kim YS, Lee SY, Kim YJ, Park JS, Oem JK. Genetic Characteristics of Avian Influenza Virus Isolated from Wild Birds in South Korea, 2019-2020. Viruses. 2021 Feb 27;13(3):381.  Abstract  
submitted by kickingbird at 4 hours ago from Viruses. 2021 Feb 27;13(3):381 (via https://www.mdpi.com/1999-4915/13/3/381)
Wild aquatic birds, a natural reservoir of avian influenza viruses (AIVs), transmit AIVs to poultry farms, causing huge economic losses. Therefore, the prevalence and genetic characteristics of AIVs isolated ...

Tiwary M, Rooney RJ, Liedmann S, LeMessurier KS, S. Eosinophil Responses at the Airway Epithelial Barrier during the Early Phase of Influenza A Virus Infection in C57BL/6 Mice. Cells. 2021 Feb 27;10(3):509.  Abstract  
submitted by kickingbird at 4 hours ago from Cells. 2021 Feb 27;10(3):509 (via https://www.mdpi.com/2073-4409/10/3/509)
Eosinophils, previously considered terminally differentiated effector cells, have multifaceted functions in tissues. We previously found that allergic mice with eosinophil-rich inflammation were protected ...

Kong M, Chen K, Zeng Z, Wang X, Gu M, Hu Z, Jiao X. The virulence modulator PA-X protein has minor effect on the pathogenicity of the highly pathogenic H7N9 avian influenza virus in mice. Vet Microbiol. 2021 Feb 26;255:109019.  Abstract  
submitted by kickingbird at 4 hours ago from Vet Microbiol. 2021 Feb 26;255:109019 (via https://www.sciencedirect.com/science/article/pii/S037811352)
PA-X is a novel discovered accessory protein encoded by the PA mRNA of the influenza A virus. Accumulated studies have demonstrated the crucial role of this protein in regulating the virulence of various ...

Mooij P, Stammes MA, Mortier D, Fagrouch Z, van Dr. Aerosolized Exposure to H5N1 Influenza Virus Causes Less Severe Disease Than Infection via Combined Intrabronchial, Oral, and Nasal Inoculation in Cynomolgus Macaques. Viruses. 2021 Feb 22;13(2):345.  Abstract  
submitted by kickingbird at 16 hours ago from Viruses. 2021 Feb 22;13(2):345 (via https://www.mdpi.com/1999-4915/13/2/345)
Infection with highly pathogenic avian H5N1 influenza virus in humans often leads to severe respiratory disease with high mortality. Experimental infection in non-human primates can provide additional ...

Pérez-Rubio G, Ponce-Gallegos MA, Domínguez-Mazzoc. Role of the Host Genetic Susceptibility to 2009 Pandemic Influenza A H1N1. Viruses. 2021 Feb 22;13(2):344.  Abstract  
submitted by kickingbird at 16 hours ago from Viruses. 2021 Feb 22;13(2):344 (via https://www.mdpi.com/1999-4915/13/2/344)
Influenza A virus (IAV) is the most common infectious agent in humans, and infects approximately 10-20% of the world's population, resulting in 3-5 million hospitalizations per year. A scientific literature ...

Phan T, Fay EJ, Lee Z, Aron S, Hu WS, Langlois RA. Segment-specific kinetics of mRNA, cRNA and vRNA accumulation during influenza infection. J Virol. 2021 Mar 3:JVI.02102-20.  Abstract  
submitted by kickingbird at 1 days ago from J Virol. 2021 Mar 3:JVI.02102-20 (via https://jvi.asm.org/content/early/2021/03/01/JVI.02102-20)
Influenza A virus (IAV) is a segmented negative-sense RNA virus and is the cause of major epidemics and pandemics. The replication of IAV is complex, involving the production of three distinct RNA species; ...

Cohen AA, Yang Z, Gnanapragasam PNP, Ou S, Dam KA,. Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers. PLoS One. 2021 Mar 4;16(3):e0247963.  Abstract  
submitted by kickingbird at 1 days ago from PLoS One. 2021 Mar 4;16(3):e0247963 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Current influenza vaccines do not elicit broadly protective immune responses against multiple strains. New strategies to focus the humoral immune response to conserved regions on influenza antigens are ...

Holzer B, Rijal P, McNee A, Paudyal B, Martini V,. Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans. PLoS Pathog. 2021 Mar 4;17(3):e1009330.  Abstract  
submitted by kickingbird at 1 days ago from PLoS Pathog. 2021 Mar 4;17(3):e1009330 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Pigs are natural hosts for the same subtypes of influenza A viruses as humans and integrally involved in virus evolution with frequent interspecies transmissions in both directions. The emergence of the ...

Kim EH, Kim YL, Kim SM, Yu KM, Casel MAB, Jang SG,. Pathogenic Assessment of Avian Influenza Viruses in Migratory Birds. Emerg Microbes Infect. 2021 Mar 5:1-40.  Abstract  
submitted by kickingbird at 1 days ago from Emerg Microbes Infect. 2021 Mar 5:1-40 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1)
Several subtypes of avian influenza (AI) viruses have caused human infections in recent years; however, there is a severe knowledge gap regarding the capacity of wild bird viruses to infect mammals. To ...

Sun H, Li F, Liu Q, Du J, Liu L, Sun H, Li C, Liu. Mink is a highly susceptible host species to circulating human and avian influenza viruses. Emerg Microbes Infect. 2021 Mar 3:1-34.  Abstract  
submitted by kickingbird at 3 days ago from Emerg Microbes Infect. 2021 Mar 3:1-34 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1)
Pandemic influenza, typically caused by reassortment of human and avian influenza viruses, can result in severe or fatal infections in humans. Timely identification of potential pandemic viruses must be ...

Hong Y, Truong AD, Lee J, Vu TH, Lee S, Song KD, L. Exosomal miRNA profiling from H5N1 avian influenza virus-infected chickens. Vet Res. 2021 Mar 3;52(1):36.  Abstract  
submitted by kickingbird at 3 days ago from Vet Res. 2021 Mar 3;52(1):36 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
Exosomes are membrane vesicles containing proteins, lipids, DNA, mRNA, and micro RNA (miRNA). Exosomal miRNA from donor cells can regulate the gene expression of recipient cells. Here, Ri chickens were ...

Luo Z, Girton AW, Heaton BE, Heaton NS. Engineered influenza virions reveal the contributions of non-hemagglutinin structural proteins to vaccine mediated protection. J Virol. 2021 Mar 3:JVI.02021-20.  Abstract  
submitted by kickingbird at 3 days ago from J Virol. 2021 Mar 3:JVI.02021-20 (via https://jvi.asm.org/content/early/2021/03/01/JVI.02021-20)
The development of improved and universal anti-influenza vaccines would represent a major advance in the protection of human health. In order to facilitate the development of such vaccines, understanding ...

Tran GVQ, Kleinehr J, Preugschas HF, Anhlan D, Moh. Nonsense-mediated mRNA decay does not restrict influenza A virus propagation. Cell Microbiol. 2021 Mar 2.  Abstract  
submitted by kickingbird at 4 days ago from Cell Microbiol. 2021 Mar 2 (via https://onlinelibrary.wiley.com/doi/10.1111/cmi.13323)
Nonsense-mediated mRNA decay (NMD) was identified as a process to degrade flawed cellular messenger RNA (mRNA). Within the last decades it was also shown that NMD carries virus-restricting capacities and ...

Zhang T, Li R, Zhong P, Chang J, Xu B. Detection of novel reassortant H9N2 avian influenza viruses in wild birds in Jiangxi Province, China. Vet Med Sci. 2021 Mar 3.  Abstract  
submitted by kickingbird at 4 days ago from Vet Med Sci. 2021 Mar 3 (via https://onlinelibrary.wiley.com/doi/10.1002/vms3.391)
The five avian influenza A/H9N2 viruses isolated from wild birds in Jiangxi, China in 2015 are novel reassortants which most likely evolved from multiple lineages. They shared a high similarity with isolates ...

Allen JD, Ross TM. Next generation methodology for updating HA vaccines against emerging human seasonal influenza A(H3N2) viruses. Sci Rep. 2021 Mar 2;11(1):4554.  Abstract  
submitted by kickingbird at 4 days ago from Sci Rep. 2021 Mar 2;11(1):4554 (via https://www.nature.com/articles/s41598-020-79590-7)
While vaccines remain the best tool for preventing influenza virus infections, they have demonstrated low to moderate effectiveness in recent years. Seasonal influenza vaccines typically consist of wild-type ...

Yechezkel M, Ndeffo Mbah ML, Yamin D. Optimizing antiviral treatment for seasonal influenza in the USA: a mathematical modeling analysis. BMC Med. 2021 Mar 1;19(1):54.  Abstract  
submitted by kickingbird at 6 days ago from BMC Med. 2021 Mar 1;19(1):54 (via https://bmcmedicine.biomedcentral.com/articles/10.1186/s1291)
Background: Seasonal influenza remains a major cause of morbidity and mortality in the USA. Despite the US Centers for Disease Control and Prevention recommendation promoting the early antiviral treatment ...

Mitchell PK, Cronk BD, Voorhees IEH, Rothenheber D. Method comparison of targeted influenza A virus typing and whole-genome sequencing from respiratory specimens of companion animals. J Vet Diagn Invest. 2020 Nov 24:1040638720933875.  Abstract  
submitted by kickingbird at 6 days ago from J Vet Diagn Invest. 2020 Nov 24:1040638720933875 (via https://journals.sagepub.com/doi/10.1177/1040638720933875)
Epidemics of H3N8 and H3N2 influenza A viruses (IAVs) in dogs, along with recognition of spillover infections from IAV strains typically found in humans or other animals, have emphasized the importance ...

Elfaki Y, Robert PA, Binz C, Falk CS, Bruder D, Pr. Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development in mice. Eur J Immunol. 2021 Feb 26.  Abstract  
submitted by kickingbird at 7 days ago from Eur J Immunol. 2021 Feb 26 (via https://onlinelibrary.wiley.com/doi/10.1002/eji.202048981)
Foxp3+ regulatory T (Treg) cells, which are crucial for maintenance of self-tolerance, mainly develop within the thymus, where they arise from CD25+ Foxp3- or CD25- Foxp3+ Treg cell precursors. Although ...

Li X, Xie S, Jiang X, Li Z, Xu L, Wen K, Zhang M,. Emergence of one novel reassortment H3N8 avian influenza virus in China, originating from North America and Eurasia. Infect Genet Evol. 2021 Feb 24:104782.  Abstract  
submitted by kickingbird at 7 days ago from Infect Genet Evol. 2021 Feb 24:104782 (via https://www.sciencedirect.com/science/article/abs/pii/S15671)
No abstract available

Radvak P, Kosikova M, Kuo YC, Li X, Garner R, Schm. Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses. NPJ Vaccines. 2021 Feb 26;6(1):30.  Abstract  
submitted by kickingbird at 8 days ago from NPJ Vaccines. 2021 Feb 26;6(1):30 (via https://www.nature.com/articles/s41541-021-00295-7)
Avian influenza A(H7N9) epidemics have a fatality rate of approximately 40%. Previous studies reported that low pathogenic avian influenza (LPAI)-derived candidate vaccine viruses (CVVs) are poorly immunogenic. ...

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