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2024-10-24 10:09:03
Article

Raju N, Kramer KJ, Cavallaro M, Diotti RA, Shiakol. Multiplexed Antibody Sequencing and Profiling of the Human Hemagglutinin-specific Memory B Cell Response following Influenza Vaccination. J Immunol. 2024 Oct 23:ji2400326.  Abstract  
submitted by kickingbird at 46 minute(s) ago from J Immunol. 2024 Oct 23:ji2400326 (via https://journals.aai.org/jimmunol/article-abstract/doi/10.40)
Influenza virus is a highly contagious respiratory pathogen causing between 9.4 and 41 million infections per year in the United States in the last decade. Annual vaccination is recommended by the World ...

Odin M, Schmeisser F, Soto J, Weir JP. A Rapid Virus-Free Method for Producing Influenza HA Immunogen Needed for Preparation of Influenza Vaccine Potency Antisera Reagents. Influenza Other Respir Viruses. 2024 Oct;18(10):e7.  Abstract  
submitted by kickingbird at 47 minute(s) ago from Influenza Other Respir Viruses. 2024 Oct;18(10):e7 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.70024)
Background: The potency of inactivated and recombinant influenza vaccines is measured using the single-radial immunodiffusion (SRID) assay. The strain-specific antigen and antibody potency reagents required ...

?al??kan, D. M., Kumar, S., Hinse, S., Schughart,. Molecular characterisation of influenza B virus from the 2017/18 season in primary models of the human lung reveals improved adaptation to the lower respiratory tract. Emerging Microbes & Infections.  Abstract  
submitted by kickingbird at 2 days ago from Emerging Microbes & Infections (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
The 2017/18 influenza season was characterized by unusual high numbers of severe infections and hospitalizations. Instead of influenza A viruses, this season was dominated by infections with influenza ...

Lang, J., Helke, D., Kuryshko, M., & Abdelwhab, E.. Survivability of H5N1 Avian Influenza Virus in Homemade Yogurt, Cheese and Whey. Emerging Microbes & Infections.  Abstract  
submitted by kickingbird at 2 days ago from Emerging Microbes & Infections (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
Influenza virus is typically associated with respiratory infections, but H5N1 in U.S. dairy cows raises public health concerns about milk by-products. We show that simple home recipes can inactivate H5N1 ...

Ahrens, A. K., Pohlmann, A., Grund, C., Beer, M.,. Out of the blue: Detection of a unique highly pathogenic avian influenza virus of subtype H7N5 in Germany. Emerging Microbes & Infections.  Abstract  
submitted by kickingbird at 2 days ago from Emerging Microbes & Infections (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
The current situation of an avian panzootic caused by highly pathogenic avian influenza viruses (HPAIV) of the goose/Guangdong lineage, subtype H5N1, clade 2.3.4.4b, is attracting significant attention ...

He, J., Liu, J., Yan, Z., Chen, G., Liu, R., Yang,. Genetic Characterization and Receptor Binding analysis of a Novel H5N1 HPAI Virus with a H6Nx-Derived PA Gene in Guangdong, China. Emerging Microbes & Infections.  Abstract  
submitted by kickingbird at 2 days ago from Emerging Microbes & Infections (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
Highly pathogenic avian influenza viruses (HPAIVs) of the H5 subtype pose a significant threat to global poultry industries and public health. Since their initial emergence in poultry in 1996 as the goose/Guangdong ...

Wang J, Shen B, Yue L, Xu H, Chen L, Qian D, Dong. The Global Trend of Drug Resistant Sites in Influenza A Virus Neuraminidase Protein from 2011 to 2020. Microorganisms. 2024; 12(10):2056.  Abstract  
submitted by kickingbird at 2 days ago from Microorganisms. 2024; 12(10):2056 (via https://www.mdpi.com/2076-2607/12/10/2056)
Influenza A virus (IAV) causes highly contagious respiratory disease worldwide, so prevention and control of IAV is extremely important. However, overuse of neuraminidase inhibitor (NAI) drugs leads to ...

Yang X, Bist RB, Subedi S, Wu Z, Liu T, Paneru B,. A Machine Vision System for Monitoring Wild Birds on Poultry Farms to Prevent Avian Influenza. AgriEngineering. 2024; 6(4):3704-3718.  Abstract  
submitted by kickingbird at 2 days ago from AgriEngineering. 2024; 6(4):3704-3718 (via https://www.mdpi.com/2624-7402/6/4/211)
The epidemic of avian influenza outbreaks, especially high-pathogenicity avian influenza (HPAI), which causes respiratory disease and death, is a disaster in poultry. The outbreak of HPAI in 2014–2015 ...

Baybay Z, Montecillo A, Pantua A, Mananggit M, Rom. Molecular Characterization of a Clade 2.3.4.4b H5N1 High Pathogenicity Avian Influenza Virus from a 2022 Outbreak in Layer Chickens in the Philippines. Pathogens. 2024; 13(10):844.  Abstract  
submitted by kickingbird at 2 days ago from Pathogens. 2024; 13(10):844 (via https://www.mdpi.com/2076-0817/13/10/844)
H5 subtype high-pathogenicity avian influenza (HPAI) viruses continue to devastate the poultry industry and threaten food security and public health. The first outbreak of H5 HPAI in the Philippines was ...

Xu DW, Tate MD. Taking AIM at Influenza: The Role of the AIM2 Inflammasome. Viruses. 2024; 16(10):1535.  Abstract  
submitted by kickingbird at 2 days ago from Viruses. 2024; 16(10):1535 (via https://www.mdpi.com/1999-4915/16/10/1535)
Influenza A viruses (IAV) are dynamic and highly mutable respiratory pathogens that present persistent public health challenges. Inflammasomes, as components of the innate immune system, play a crucial ...

Galeone V, Lee C, Monaghan MT, Bauer DC, Wilson LO. Evolutionary Insights from Association Rule Mining of Co-Occurring Mutations in Influenza Hemagglutinin and Neuraminidase. Viruses. 2024; 16(10):1515.  Abstract  
submitted by kickingbird at 2 days ago from Viruses. 2024; 16(10):1515 (via https://www.mdpi.com/1999-4915/16/10/1515)
Seasonal influenza viruses continuously evolve via antigenic drift. This leads to recurring epidemics, globally significant mortality rates, and the need for annually updated vaccines. Co-occurring mutations ...

Hailiang Sun, etc.,al. Genetic evolution, phylodynamic and phylogeographic of H5Ny AIVs in mammals. Animals and Zoonoses.  Abstract  
submitted by kickingbird at 2 days ago from Animals and Zoonoses (via https://www.sciencedirect.com/science/article/pii/S295024892)
The growing incidence of H5Ny virus infection in humans and mammals causes an increasing public health concern. To date, H5Ny virus infection in humans and mammals has been reported in 46 countries around ...

Miyu Moriyama, etc.,al. [preprint]Intranasal hemagglutinin protein boosters induce robust mucosal immunity and cross-protection against influenza A viral challenge. https://doi.org/10.1101/2024.10.10.616291.  Abstract  
submitted by kickingbird at 4 days ago from https://doi.org/10.1101/2024.10.10.616291 (via https://www.biorxiv.org/content/10.1101/2024.10.10.616291v1)
Licensed parenteral influenza vaccines induce systemic antibody responses and alleviate disease severity but do not efficiently prevent viral entry and transmission due to the lack of local mucosal immune ...

Qiu Yu Huang, etc.,al. [preprint]Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryo-electron tomography. https://doi.org/10.1101/2024.10.15.618557.  Abstract  
submitted by kickingbird at 4 days ago from https://doi.org/10.1101/2024.10.15.618557 (via https://www.biorxiv.org/content/10.1101/2024.10.15.618557v1)
Influenza viruses are enveloped, negative sense single-stranded RNA viruses covered in a dense layer of glycoproteins. Hemagglutinin (HA) accounts for 80-90% of influenza glycoprotein and plays a role ...

Zhang M, Zeng Y, Liu Q, Li F, Zhao J, Liu Z, Liu H. The H5N1-NS1 protein affects the host cell cycle and apoptosis through interaction with the host lncRNA PIK3CD-AS2. Virus Genes. 2024 Oct 18.  Abstract  
submitted by kickingbird at 4 days ago from Virus Genes. 2024 Oct 18 (via https://link.springer.com/article/10.1007/s11262-024-02118-y)
Long noncoding RNAs (lncRNAs) are involved in the host antiviral response, but how host lncRNAs interact with viral proteins remains unclear. The NS1 protein of avian influenza viruses can affect the interferon-dependent ...

Richard Webby, etc.,al. [preprint] Efficacy of oseltamivir and baloxavir against A(H5N1)-contaminated bovine milk in mice. https://doi.org/10.21203/rs.3.rs-5119512/v1.  Abstract  
submitted by kickingbird at 5 days ago from https://doi.org/10.21203/rs.3.rs-5119512/v1 (via https://www.researchsquare.com/article/rs-5119512/v1)
Understanding the reliability of FDA-approved antivirals against A(H5N1) influenza viruses circulating in peridomestic species including dairy cows is critical to public health and pre-pandemic planning, ...

Lisovski S, Günther A, Dewar M, Ainley D, Aldunate. Unexpected Delayed Incursion of Highly Pathogenic Avian Influenza H5N1 (Clade 2.3.4.4b) Into the Antarctic Region. Influenza Other Respir Viruses. 2024 Oct;18(10):e7.  Abstract  
submitted by kickingbird at 5 days ago from Influenza Other Respir Viruses. 2024 Oct;18(10):e7 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.70010)
The current highly pathogenic avian influenza H5N1 panzootic is having substantial impacts on wild birds and marine mammals. Following major and widespread outbreaks in South America, an incursion to Antarctica ...

Alessandro Zulli, etc.,al. [preprint]Infectivity and persistence of influenza viruses in raw milk. https://doi.org/10.1101/2024.10.10.24315269.  Abstract  
submitted by kickingbird at 5 days ago from https://doi.org/10.1101/2024.10.10.24315269 (via https://www.medrxiv.org/content/10.1101/2024.10.10.24315269v)
Influenza A viruses present a significant public health risk, with recent outbreaks of highly pathogenic avian influenza (HPAI) H5N1 in dairy cattle raising concerns about potential transmission through ...

Jennifer Schrock, etc.,al. Survivability of low pathogenic avian influenza virus in aqueous poultry manure fertilizer. Journal of Applied Poultry Research, 17 Oct 2024.  Abstract  
submitted by kickingbird at 6 days ago from Journal of Applied Poultry Research, 17 Oct 2024 (via https://www.sciencedirect.com/science/article/pii/S105661712)
Avian influenza has been a growing problem in the United States for decades. Low pathogenic avian influenza (LPAI) virus causes low morbidity, while highly pathogenic avian influenza (HPAI) has a devastating ...

Li, R., Gao, J., Wang, L. et al. Multivalent interactions between fully glycosylated influenza virus hemagglutinins mediated by glycans at distinct N-glycosylation sites. npj Viruses 2, 48 (2024).  Abstract  
submitted by kickingbird at 6 days ago from npj Viruses 2, 48 (2024) (via https://www.nature.com/articles/s44298-024-00059-9)
The hemagglutinin (HA) glycoprotein of influenza virus binds host cell receptors and mediates viral entry. Here we present cryo-EM structures of fully glycosylated HAs from H5N1 and H5N8 influenza viruses. ...

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