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2018-9-25 2:28:40
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Li L, DeLiberto TJ, Killian ML, Torchetti MK, et a. Evolutionary pathway for the 2017 emergence of a novel highly pathogenic avian influenza A(H7N9) virus among domestic poultry in Tennessee, United States. Virology. 2018 Sep 17.  Abstract  
submitted by kickingbird at 15 hours ago from Virology. 2018 Sep 17 (via https://www.ncbi.nlm.nih.gov/m/pubmed/30236990/)
In March 2017, a novel highly pathogenic avian influenza A(H7N9) virus was detected at two commercial broiler breeder facilities in Tennessee, United States. In this study, a wild bird low pathogenic avian ...

DeDiego ML, Chiem K, Topham DJ.. Directed selection of amino acid changes in the influenza hemagglutinin and neuraminidase affecting protein antigenicity. Vaccine. 2018 Sep 14..  Abstract  
submitted by kickingbird at 15 hours ago from Vaccine. 2018 Sep 14. (via https://www.ncbi.nlm.nih.gov/m/pubmed/30224200/)
Influenza virus hemagglutinin (HA) and neuraminidase (NA) proteins elicit protective antibody responses and therefore, are used as targets for vaccination, especially the HA protein. However, these proteins ...

Benton DJ, Nans A, Calder LJ, Turner J, et al. Influenza hemagglutinin membrane anchor. Proc Natl Acad Sci U S A. 2018 Sep 17.  Abstract  
submitted by kickingbird at 15 hours ago from Proc Natl Acad Sci U S A. 2018 Sep 17 (via https://www.ncbi.nlm.nih.gov/m/pubmed/30224494/)
Viruses with membranes fuse them with cellular membranes, to transfer their genomes into cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved in fusion is the hemagglutinin ...

Gonzalez AJ, Ijezie EC, Balemba OB, Miura TA, et a. Attenuation of influenza A virus disease severity by viral co-infection in a mouse model. J Virol. 2018 Sep 19..  Abstract  
submitted by kickingbird at 15 hours ago from J Virol. 2018 Sep 19. (via https://www.ncbi.nlm.nih.gov/m/pubmed/30232180/)
Influenza viruses and rhinoviruses are responsible for a large number of acute respiratory viral infections in human populations and are detected as co-pathogens within hosts. Clinical and epidemiological ...

Scheller N, et al.. Pro-viral miRNAs detected in BALF extracellular vesicles of patients with influenza virus-induced ARDS. J Infect Dis. 2018 Sep 15.  Abstract  
submitted by kickingbird at 15 hours ago from J Infect Dis. 2018 Sep 15 (via https://www.ncbi.nlm.nih.gov/m/pubmed/30239899/)
Influenza A virus (IAV) causes severe respiratory infections and alveolar epithelial damage resulting in acute respiratory distress syndrome (ARDS). Extracellular vesicles (EV) have been shown to mediate ...

Santner P, Martins JMDS, Kampmeyer C, Hartmann-Pet. Random mutagenesis analysis of the Influenza A M2 proton channel reveals novel resistance mutants. Biochemistry 2018 Sep 19..  Abstract  
submitted by kickingbird at 15 hours ago from Biochemistry 2018 Sep 19. (via https://www.ncbi.nlm.nih.gov/m/pubmed/30230310/)
The influenza M2 proton channel is a major drug target, but unfortunately, the acquisition of resistance mutations greatly reduces the functional life-span of a drug in influenza treatment. New M2 inhibitors ...

Louisa E. Sjaastad, Elizabeth J. Fay, Jessica K. F. Distinct antiviral signatures revealed by the magnitude and round of influenza virus replication in vivo. PNAS September 18, 2018 115 (38) 9610-9615.  Abstract  
submitted by kickingbird at 4 days ago from PNAS September 18, 2018 115 (38) 9610-9615 (via http://www.pnas.org/content/115/38/9610)
Influenza virus has a broad cellular tropism in the respiratory tract. Infected epithelial cells sense the infection and initiate an antiviral response. To define the antiviral response at the earliest ...

Astill J, etc.,al. A Comparison of Toll-Like Receptor 5 and 21 Ligands as Adjuvants for a Formaldehyde Inactivated H9N2 Avian Influenza Virus Vaccine in Chickens. Viral Immunol. 2018 Sep 15..  Abstract  
submitted by kickingbird at 5 days ago from Viral Immunol. 2018 Sep 15. (via https://www.ncbi.nlm.nih.gov/pubmed/30222508)
Low pathogenic avian influenza virus (AIV) infection in chickens can result in economic losses and has impacts on human health. Poultry vaccination is a tool that can be used to decrease infection and ...

Poolkhet C, etc.,al. Exponential random graph models to evaluate the movement of backyard chickens after the avian influenza crisis in 2004~2005, Thailand. Prev Vet Med. 2018 Oct 1;158:71-77..  Abstract  
submitted by kickingbird at 5 days ago from Prev Vet Med. 2018 Oct 1;158:71-77. (via https://www.ncbi.nlm.nih.gov/pubmed/30220398)
The aim of this study was to use exponential random graph models (ERGMs) to explain networks of movement of backyard chickens in provinces which had been hotspots for avian influenza outbreaks in Thailand ...

Phillips AM, etc.,al. Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones. PLoS Biol. 2018 Sep 17;16(9):e3000008.  Abstract  
submitted by kickingbird at 5 days ago from PLoS Biol. 2018 Sep 17;16(9):e3000008 (via https://www.ncbi.nlm.nih.gov/pubmed/30222731)
The threat of viral pandemics demands a comprehensive understanding of evolution at the host-pathogen interface. Here, we show that the accessibility of adaptive mutations in influenza nucleoprotein at ...

Treurnicht FK, etc.,al. Replacement of neuraminidase inhibitor susceptible influenza A(H1N1) with resistant phenotype in 2008 and circulation of susceptible influenza A and B viruses during 2009-2013, South Africa. Influenza Other Respir Viruses. 2018 Sep 14..  Abstract  
submitted by kickingbird at 5 days ago from Influenza Other Respir Viruses. 2018 Sep 14. (via https://www.ncbi.nlm.nih.gov/pubmed/30218485)
BACKGROUND: Data on the susceptibility of influenza viruses from South Africa to neuraminidase inhibitors (NAIs) is scarce, and no extensive analysis was done.OBJECTIVES: We aimed to determine oseltamivir ...

Neyer VL, Woo JG, Siegel RM. Severe Obesity in Children May Not Pose Independent Risk for Influenza Complications. J Pediatr Nurs. 2018 Sep - Oct;42:21-24.  Abstract  
submitted by kickingbird at 5 days ago from J Pediatr Nurs. 2018 Sep - Oct;42:21-24 (via https://www.ncbi.nlm.nih.gov/pubmed/30219295)
PURPOSE: Subsets of children are targeted for influenza vaccination due to known conditions that increase the risk of influenza complications. The purpose of this study was to determine if severe obesity ...

Abed Y, etc.,al. Comparison of early and recent influenza A(H1N1)pdm09 isolates harboring or not the H275Y neuraminidase mutation, in vitro and in animal models. Antiviral Res. 2018 Sep 13..  Abstract  
submitted by kickingbird at 5 days ago from Antiviral Res. 2018 Sep 13. (via https://www.ncbi.nlm.nih.gov/pubmed/30219318)
After 6 years of circulation in humans, a novel antigenic variant of influenza A(H1N1)pdm09 (i.e., A/Michigan/45/2015) emerged in 2015-16 and has predominated thereafter worldwide. Herein, we compared ...

Bolton MJ, etc.,al. Antigenic evolution of H3N2 influenza A viruses in swine in the United States from 2012 to 2016. Influenza Other Respir Viruses. 2018 Sep 14.  Abstract  
submitted by kickingbird at 5 days ago from Influenza Other Respir Viruses. 2018 Sep 14 (via https://www.ncbi.nlm.nih.gov/pubmed/30216671)
BACKGROUND: Six amino acid positions (145, 155, 156, 158, 159 and 189, referred to as the antigenic motif; H3 numbering) in the globular head region of hemagglutinin (HA1 domain) play an important role ...

Garnacho-Montero J, etc.,al. Clinical characteristics, evolution, and treatment-related risk factors for mortality among immunosuppressed patients with influenza A (H1N1) virus admitted to the intensive care unit.. J Crit Care. 2018 Aug 24;48:172-177..  Abstract  
submitted by kickingbird at 5 days ago from J Crit Care. 2018 Aug 24;48:172-177. (via https://www.ncbi.nlm.nih.gov/pubmed/30216935)
PURPOSE: Information about immunocompromised patients infected with influenza A (H1N1) virus and requiring admission to the ICU is lacking. Our objective was to know the clinical characteristics of these ...

Mostafa A, Abdelwhab EM, Mettenleiter TC. Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview. Viruses. 2018 Sep 13;10(9).  Abstract  
submitted by kickingbird at 5 days ago from Viruses. 2018 Sep 13;10(9) (via https://www.ncbi.nlm.nih.gov/pubmed/30217093)
Influenza A viruses (IAVs) possess a great zoonotic potential as they are able to infect different avian and mammalian animal hosts, from which they can be transmitted to humans. This is based on the ability ...

Hewei Zhang, etc.,al. Influenza C Virus in Cattle with Respiratory Disease, United States, 2016~2018. EID,Vol 24, Issue 10 Oct 2018.  Abstract  
submitted by kickingbird at 7 days ago from EID,Vol 24, Issue 10 Oct 2018 (via https://wwwnc.cdc.gov/eid/article/24/10/18-0589_article)
We identified influenza C virus (ICV) in samples from US cattle with bovine respiratory disease through real-time PCR testing and sequencing. Bovine ICV isolates had high nucleotide identities (≈98%) with ...

Andrew M. Ramey, etc.,al. Introduction of Eurasian-Origin Influenza A(H8N4) Virus into North America by Migratory Birds. EID,Vol 24, Issue 10 Oct 2018.  Abstract  
submitted by kickingbird at 7 days ago from EID,Vol 24, Issue 10 Oct 2018 (via https://wwwnc.cdc.gov/eid/article/24/10/18-0447_article)
We identified a Eurasian-origin influenza A(H8N4) virus in North America by sampling wild birds in western Alaska, USA. Evidence for repeated introductions of influenza A viruses into North America by ...

Jung-Hoon Kwon, etc.,al. New Reassortant Clade 2.3.4.4b Avian Influenza A(H5N6) Virus in Wild Birds, South Korea, 2017~18. EID,Vol 24, Issue 10 Oct 2018.  Abstract  
submitted by kickingbird at 7 days ago from EID,Vol 24, Issue 10 Oct 2018 (via https://wwwnc.cdc.gov/eid/article/24/10/18-0461_article)
We isolated new reassortant avian influenza A(H5N6) viruses from feces of wild waterfowl in South Korea during 2017–18. Phylogenetic analysis suggested that reassortment occurred between clade 2.3.4.4b ...

Masato Hatta, etc.,al. Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A(H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus. EID,Vol 24, Issue 10 Oct 2018.  Abstract  
submitted by kickingbird at 7 days ago from EID,Vol 24, Issue 10 Oct 2018 (via https://wwwnc.cdc.gov/eid/article/24/10/18-0403_article)
The recent emergence of highly pathogenic influenza A(H7N9) variants poses a great risk to humans. We show that ferrets vaccinated with low pathogenicity H7N9 virus vaccine do not develop severe symptoms ...

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