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2017-10-21 7:08:28
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Duh D, Blazic B. Single mutation in the matrix gene of seasonal influenza A viruses critically affects the performance of diagnostic molecular assay. J Virol Methods 2017 Oct 6.  Abstract  
submitted by kickingbird at 5 days ago from J Virol Methods 2017 Oct 6 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28993123/)
Reduced intensity of the fluorescence signal in the amplification curve was observed when using a WHO recommended real time RT-PCR for influenza virus detection. A single mutation, G189T, in the conserved ...

Cho J, Yi H, Jang EY, Lee MS, et al. Mycophenolic mofetil, an alternative antiviral and immunomodulator for the highly pathogenic avian influenza H5N1 virus infection. Biochem Biophys Res Commun 2017 Oct 7.  Abstract  
submitted by kickingbird at 5 days ago from Biochem Biophys Res Commun 2017 Oct 7 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29017920/)
Infection with the highly pathogenic avian influenza H5N1 virus results in a high incidence of mortality in humans. Severe complications from infection are often associated with hypercytokinemia. However, ...

Tilmanis D, van Baalen C, Oh DY, Rossignol JF, et. The susceptibility of circulating human influenza viruses to tizoxanide, the active metabolite of nitazoxanide. Antiviral Res 2017 Oct 3.  Abstract  
submitted by kickingbird at 5 days ago from Antiviral Res 2017 Oct 3 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28986103/)
Nitazoxanide is a thiazolide compound that was originally developed as an anti-parasitic agent, but has recently been repurposed for the treatment of influenza virus infections. Thought to exert its anti-influenza ...

Carter DM, Darby CA, Johnson SK, Carlock MA, et al. Elicitation of protective antibodies against a broad panel of H1N1 viruses in ferrets pre-immune to historical H1N1 influenza viruses. J Virol 2017 Oct 4.  Abstract  
submitted by kickingbird at 12 days ago from J Virol 2017 Oct 4 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28978709/)
Most pre-clinical animal studies test influenza vaccines in immunologically na?ve animal models, even though the results of vaccination may not accurately reflect the effectiveness of vaccine candidates ...

Wong TM, Allen JD, Bebin-Blackwell AG, Carter DM,. COBRA HA elicits hemagglutination-inhibition antibodies against a panel of H3N2 influenza virus co-circulating variants. J Virol 2017 Oct 4.  Abstract  
submitted by kickingbird at 12 days ago from J Virol 2017 Oct 4 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28978710/)
Each influenza season, a set of wild-type viruses, representing one H1N1, one H3N2, 1-2 influenza B isolates, are selected for inclusion in the annual seasonal influenza vaccine. In order to develop broadly ...

Yoon SW, Wong SS, Zhu H, Chen R, et al. Dysregulated T-Helper Type 1 (Th1):Th2 Cytokine Profile and Poor Immune Response in Pregnant Ferrets Infected With 2009 Pandemic Influenza A(H1N1) Virus. J Infect Dis 2017 Jul 18.  Abstract  
submitted by kickingbird at 12 days ago from J Infect Dis 2017 Jul 18 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28973317/)
Pregnancy has been associated with severe influenza, an association highlighted during the 2009 pandemic of influenza A(H1N1) virus (A[H1N1]pdm09) infection. To assess the underlying mechanism, we infected ...

Wu Y, Yang D, Xu B, Liang W, et al.. Immune efficacy of an adenoviral vector-based swine influenza vaccine against antigenically distinct H1N1 strains in mice. Antiviral Res 2017 Sep 20.  Abstract  
submitted by kickingbird at Oct, 3, 2017 from Antiviral Res 2017 Sep 20 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28941982/)
Avian-like H1N1 swine influenza viruses are prevalent in pigs and have occasionally crossed the species barrier and infected humans, which highlights the importance of preventing swine influenza. Human ...

Andersen TK, Zhou F, Cox R, Bogen B, et al. A DNA vaccine that targets hemagglutinin to antigen presenting cells protects mice against H7 influenza. J Virol 2017 Sep 20.  Abstract  
submitted by kickingbird at Sep, 25, 2017 from J Virol 2017 Sep 20 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28931687/)
Zoonotic influenza H7 viral infections have a case fatality rate of about 40%. Currently no or limited human to human spread has occurred, but we may be facing a severe pandemic threat if the virus acquires ...

Naguib MM, Ulrich R, Kasbohm E, Eng CLP, et al. Natural reassortants between potentially zoonotic avian influenza viruses H5N1 and H9N2 from Egypt display distinct pathogenic phenotypes in experimentally infected chickens and ferrets. J Virol 2017 Sep 20.  Abstract  
submitted by kickingbird at Sep, 25, 2017 from J Virol 2017 Sep 20 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28931674/)
Co-circulation of zoonotic highly pathogenic avian influenza virus (HPAIV) H5N1 and AIV of subtype H9N2 among poultry in Egypt for at least six years should render this country a hypothetical hotspot for ...

Kiso M, Iwatsuki-Horimoto K, Yamayoshi S, Uraki R,. Emergence of Oseltamivir-Resistant H7N9 Influenza Viruses in Immunosuppressed Cynomolgus Macaques. J Infect Dis 2017;216:582-593.  Abstract  
submitted by kickingbird at Sep, 25, 2017 from J Infect Dis 2017;216:582-593 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28931216/)
Antiviral compounds (eg, the neuraminidase inhibitor oseltamivir) are invaluable for the treatment of individuals infected with influenza A viruses of the H7N9 subtype (A[H7N9]), which have infected and ...

Skowronski DM, Chambers C, De Serres G, Sabaiduc S. Age-Related Differences in Influenza B Infection by Lineage in a Community-Based Sentinel System, 2010-2011 to 2015-2016, Canada. J Infect Dis 2017;216:697-702..  Abstract  
submitted by kickingbird at Sep, 25, 2017 from J Infect Dis 2017;216:697-702. (via https://www.ncbi.nlm.nih.gov/m/pubmed/28934439/)
Age-related differences in influenza B lineage detection were explored in the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN) from 2010-2011 to 2015-2016. Whereas >80% of B(Victoria) ...

Belser JA, Creager HM, Zeng H, Maines TR, et al. Pathogenesis, Transmissibility, and Tropism of a Highly Pathogenic Avian Influenza A(H7N7) Virus Associated With Human Conjunctivitis in Italy, 2013. J Infect Dis. 2017;216.  Abstract  
submitted by kickingbird at Sep, 25, 2017 from J Infect Dis. 2017;216 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28934452/)
H7 subtype influenza viruses represent a persistent public health threat because of their continued detection in poultry and ability to cause human infection. An outbreak of highly pathogenic avian influenza ...

Gubareva LV, Sleeman K, Guo Z, Yang H, et al. Drug Susceptibility Evaluation of an Influenza A(H7N9) Virus by Analyzing Recombinant Neuraminidase Proteins.. J Infect Dis 2017;216.  Abstract  
submitted by kickingbird at Sep, 25, 2017 from J Infect Dis 2017;216 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28934455/)
Background: Neuraminidase (NA) inhibitors are the recommended antiviral medications for influenza treatment. However, their therapeutic efficacy can be compromised by NA changes that emerge naturally ...

Chakraborty A, Rahman M, Hossain MJ, Khan SU, et a. Mild Respiratory Illness Among Young Children Caused by Highly Pathogenic Avian Influenza A (H5N1) Virus Infection in Dhaka, Bangladesh, 2011.. J Infect Dis 2017;216.  Abstract  
submitted by kickingbird at Sep, 25, 2017 from J Infect Dis 2017;216 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28934459/)
Background: In March 2011, a multidisciplinary team investigated 2 human cases of highly pathogenic avian influenza A(H5N1) virus infection, detected through population-based active surveillance for influenza ...

Liu F, Veguilla V, Gross FL, Gillis E, et al.. Effect of Priming With Seasonal Influenza A(H3N2) Virus on the Prevalence of Cross-Reactive Hemagglutination-Inhibition Antibodies to Swine-Origin A(H3N2) Variants. J Infect Dis 2017;216.  Abstract  
submitted by kickingbird at Sep, 25, 2017 from J Infect Dis 2017;216 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28934461/)
Background: Recent outbreaks of swine-origin influenza A(H3N2) variant (H3N2v) viruses have raised public health concerns. Previous studies indicated that older children and young adults had the highest ...

WANG Haijun, etc al. Identification of H5N1 subtype avian influenza virus from captive Panthera Tigris and analysis of HA and NA gene. Chin J Vet Sci, Nov 2017 Vol.37 No.11.  Abstract  
submitted by kickingbird at Sep, 20, 2017 from Chin J Vet Sci, Nov 2017 Vol.37 No.11 (via http://www.cnki.net)
Abstract: Influenza A viruses belongs to the genus Strains of Sweat Virus,which is threatening the health of humans and animals,resulting in plenty of economic loss and increasing the burden on society.In ...

Takemae N, Tsunekuni R, Sharshov K, Tanikawa T, et. Five distinct reassortants of H5N6 highly pathogenic avian influenza A viruses affected Japan during the winter of 2016-2017. Virology 2017;512:8-20.  Abstract  
submitted by kickingbird at Sep, 18, 2017 from Virology 2017;512:8-20 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28892736/)
To elucidate the evolutionary pathway, we sequenced the entire genomes of 89 H5N6 highly pathogenic avian influenza viruses (HPAIVs) isolated in Japan during winter 2016-2017 and 117 AIV/HPAIVs isolated ...

Adamson PJ, Al Kindi MA, Wang JJ, Colella AD, et a. Proteomic analysis of influenza haemagglutinin-specific antibodies following vaccination reveals convergent immunoglobulin variable region signatures. Vaccine 2017 Sep 6..  Abstract  
submitted by kickingbird at Sep, 18, 2017 from Vaccine 2017 Sep 6. (via https://www.ncbi.nlm.nih.gov/m/pubmed/28888340/)
Analysis of the anti-haemagglutinin serum antibody proteome from six H1N1pdm09 influenza A vaccinated subjects demonstrated restricted IgG1 heavy chain species encoded by IGHV5-51 and IGHV3-7 gene families ...

CIMINSKI K, Thamamongood T, Zimmer G, Schwemmle M,. Novel insights into bat influenza A viruses. J Gen Virol. 2017 Sep 14.  Abstract  
submitted by kickingbird at Sep, 18, 2017 from J Gen Virol. 2017 Sep 14 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28906230/)
In 2012 and 2013, influenza virus genome sequences of two new influenza A virus (IAV) subtypes were discovered in bat specimens, but further characterization was largely impeded by the lack of infectious ...

Kim YJ, Ko EJ, Kim MC, Lee YN, et al. Roles of antibodies to influenza A virus hemagglutinin, neuraminidase, and M2e in conferring cross protection.. Biochem Biophys Res Commun 2017 Sep 5.  Abstract  
submitted by kickingbird at Sep, 18, 2017 from Biochem Biophys Res Commun 2017 Sep 5 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28887040/)
Although neuraminidase (NA) is the second major viral glycoprotein of influenza virus, its immune mechanism as a vaccine target has been less considered. Here we compared the properties of antibodies and ...

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