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2018-11-16 22:59:45
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Song L, Xiong D, Kang X, Jiao Y, et al.. The optimized fusion protein HA1-2-FliC△D2D3 promotes mixed Th1/Th2 immune responses to influenza H7N9 with low induction of systemic proinflammatory cytokines in mice. Antiviral Res 2018 Oct 30.  Abstract  
submitted by kickingbird at 2 days ago from Antiviral Res 2018 Oct 30 (via https://www.ncbi.nlm.nih.gov/pubmed/30389471)
H7N9 influenza virus has an unusually high fatality rate of approximately 40%, and a safe and effective vaccine against this subtype is urgently needed. Flagellin, a Toll-like receptor (TLR) 5 agonist, ...

Jia X, et al. Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration. PLoS Pathog. 2018 Nov 13;14(11):.  Abstract  
submitted by kickingbird at 2 days ago from PLoS Pathog. 2018 Nov 13;14(11): (via https://www.ncbi.nlm.nih.gov/pubmed/30422993)
Severe influenza A virus infection causes high mortality and morbidity worldwide due to delayed antiviral treatment and inducing overwhelming immune responses, which contribute to immunopathological lung ...

Chen T, Xiao M, Yang J, Chen YK, Bai T, et al. Association between rs12252 and influenza susceptibility and severity: an updated meta-analysis. Epidemiol Infect. 2018 Nov 13:1-9.  Abstract  
submitted by kickingbird at 2 days ago from Epidemiol Infect. 2018 Nov 13:1-9 (via https://www.ncbi.nlm.nih.gov/pubmed/30421689)
In several lately published studies, the association between single-nucleotide polymorphism (SNP, rs12252) of IFITM3 and the risk of influenza is inconsistent. To further understand the association between ...

Littauer EQ, Skountzou I. Hormonal Regulation of Physiology, Innate Immunity and Antibody Response to H1N1 Influenza Virus Infection During Pregnancy. Front Immunol. 2018 Oct 29;9:2455.  Abstract  
submitted by kickingbird at 2 days ago from Front Immunol. 2018 Oct 29;9:2455 (via https://www.ncbi.nlm.nih.gov/pubmed/30420854)
In 2009, the H1N1 swine flu pandemic highlighted the vulnerability of pregnant women to influenza viral infection. Pregnant women infected with influenza A virus were at increased risk of hospitalization ...

Lee KM, et al. Coinfection With Influenza A Virus and Klebsiella oxytoca: An Underrecognized Impact on Host Resistance and Tolerance to Pulmonary Infections. Front Immunol. 2018 Oct 29;9:2377.  Abstract  
submitted by kickingbird at 2 days ago from Front Immunol. 2018 Oct 29;9:2377 (via https://www.ncbi.nlm.nih.gov/pubmed/30420852)
Pneumonia is a world health problem and a leading cause of death, particularly affecting children and the elderly (1, 2). Bacterial pneumonia following infection with influenza A virus (IAV) is associated ...

Wohlgemuth N, Lane AP, Pekosz A. Influenza A Virus M2 Protein Apical Targeting Is Required for Efficient Virus Replication. J Virol. 2018 Oct 29;92(22)..  Abstract  
submitted by kickingbird at 3 days ago from J Virol. 2018 Oct 29;92(22). (via https://www.ncbi.nlm.nih.gov/pubmed/30158290)
The influenza A virus (IAV) M2 protein is a multifunctional protein with critical roles in virion entry, assembly, and budding. M2 is targeted to the apical plasma membrane of polarized epithelial cells, ...

Ather JL, et al. Serum Amyloid A3 is required for normal lung development and survival following influenza infection. Sci Rep. 2018 Nov 8;8(1):16571..  Abstract  
submitted by kickingbird at 3 days ago from Sci Rep. 2018 Nov 8;8(1):16571. (via https://www.ncbi.nlm.nih.gov/pubmed/30410021)
Serum amyloid A (SAA) proteins are a family of acute phase apolipoproteins implicated to directly modulate innate and adaptive immune responses. However, new studies comparing endogenous SAAs and recombinant ...

Mine J, et al. Genetic and antigenic dynamics of influenza A viruses of swine on pig farms in Thailand. Arch Virol. 2018 Nov 10..  Abstract  
submitted by kickingbird at 3 days ago from Arch Virol. 2018 Nov 10. (via https://www.ncbi.nlm.nih.gov/pubmed/30415389)
Surveillance studies of influenza A virus of swine (IAV-S) have accumulated information regarding IAVs-S circulating in Thailand, but how IAVs-S evolve within a farm remains unclear. In the present study, ...

Franklin AB, et al. Predicting the initial spread of novel Asian origin influenza A viruses in the continental United States by wild waterfowl. Transbound Emerg Dis. 2018 Nov 11..  Abstract  
submitted by kickingbird at 3 days ago from Transbound Emerg Dis. 2018 Nov 11. (via https://www.ncbi.nlm.nih.gov/pubmed/30415502)
Using data on waterfowl band recoveries, we identified spatially-explicit hotspots of concentrated waterfowl movement to predict occurrence and spatial spread of a novel influenza A virus (clade 2.3.4.4) ...

Peacock TP, et al. The molecular basis of antigenic variation among A(H9N2) avian influenza viruses. Emerg Microbes Infect. 2018 Nov 7;7(1):176..  Abstract  
submitted by kickingbird at 5 days ago from Emerg Microbes Infect. 2018 Nov 7;7(1):176. (via https://www.ncbi.nlm.nih.gov/pubmed/30401826)
Avian influenza A(H9N2) viruses are an increasing threat to global poultry production and, through zoonotic infection, to human health where they are considered viruses with pandemic potential. Vaccination ...

Wang P, Zhu W, Liao B, Cai L, Peng L, Yang J. Predicting Influenza Antigenicity by Matrix Completion With Antigen and Antiserum Similarity. Front Microbiol. 2018 Oct 23;9:2500.  Abstract  
submitted by kickingbird at 5 days ago from Front Microbiol. 2018 Oct 23;9:2500 (via https://www.ncbi.nlm.nih.gov/pubmed/30405563)
The rapid mutation of influenza viruses especially on the two surface proteins hemagglutinin (HA) and neuraminidase (NA) has made them capable to escape from population immunity, which has become a key ...

Qin J, Zhang Y, Shen X, Gong L, Xue C, Cao Y. Biological characteristics and immunological properties in Muscovy ducks of H5N6 virus-like particles composed of HA-TM/HA-TMH3 and M1. Avian Pathol. 2018 Nov 8:1-35.  Abstract  
submitted by kickingbird at 5 days ago from Avian Pathol. 2018 Nov 8:1-35 (via https://www.ncbi.nlm.nih.gov/pubmed/30404538)
Highly pathogenic avian influenza viruses (HPAIVs), including H5N6 strains, pose threats to the health of humans and poultry. Waterfowl play a crucial role in HPAIVs. Since current influenza vaccines induce ...

Mayr J, et al. Unravelling the Role of O-glycans in Influenza A Virus Infection. Sci Rep. 2018 Nov 6;8(1):16382.  Abstract  
submitted by kickingbird at 5 days ago from Sci Rep. 2018 Nov 6;8(1):16382 (via https://www.ncbi.nlm.nih.gov/pubmed/30401951)
The initial stage of host cell infection by influenza A viruses (IAV) is mediated through interaction of the viral haemagglutinin (HA) with cell surface glycans. The binding requirement of IAVs for Galβ(1,4)Glc/ ...

Rodriguez L, Nogales A, Iqbal M, Perez DR, et al. Identification of Amino Acid Residues Responsible for Inhibition of Host Gene Expression by Influenza A H9N2 NS1 Targeting of CPSF30. Front Microbiol. 2018 Oct 24;9:2546..  Abstract  
submitted by kickingbird at 5 days ago from Front Microbiol. 2018 Oct 24;9:2546. (via https://www.ncbi.nlm.nih.gov/pubmed/30405591)
H9N2 influenza A viruses (IAV) are considered low pathogenic avian influenza viruses (LPAIV). These viruses are endemic in poultry in many countries in Asia, the Middle East and parts of Africa. Several ...

Ma G, et al. Histone acetyl transferase TIP60 inhibits the replication of influenza a virus by activation the TBK1-IRF3 pathway. Virol J. 2018 Nov 8;15(1):172..  Abstract  
submitted by kickingbird at 5 days ago from Virol J. 2018 Nov 8;15(1):172. (via https://www.ncbi.nlm.nih.gov/pubmed/30409205)
Influenza A virus (IAV) is an important pathogen that poses a severe threat to the health of humans. Nucleoprotein (NP) of IAV plays crucial roles in the viral life cycle by interacting with various cellular ...

Lyu Y, Song S, Zhou L, Bing G, Wang Q, Sun Haoran,. Canine Influenza Virus A(H3N2) Clade with Antigenic Variation, China, 2016~2017. Emerg Infect Dis. 2019 Jan.  Abstract  
submitted by kickingbird at 6 days ago from Emerg Infect Dis. 2019 Jan (via https://wwwnc.cdc.gov/eid/article/25/1/17-1878_article)
During 2012-2017, we collected throat swabs from dogs in China to characterize canine influenza virus (CIV) A(H3N2) isolates. A new antigenically and genetically distinct CIV H3N2 clade possessing mutations ...

Rudenko L, et al. Two Live Attenuated Vaccines against Recent Low and Highly Pathogenic H7N9 Influenza Viruses Are Safe and Immunogenic in Ferrets. Vaccines (Basel). 2018 Nov 1;6(4)..  Abstract  
submitted by kickingbird at 9 days ago from Vaccines (Basel). 2018 Nov 1;6(4). (via https://www.ncbi.nlm.nih.gov/pubmed/30388790)
Influenza H7N9 virus is a potentially pandemic subtype to which most people are immunologically naive. To be better prepared for the potential occurrence of an H7N9 pandemic, in 2017 the World Health Organization ...

Moasser E, Moasser A, Zaraket H. Incidence of antiviral drug resistance markers among human influenza A viruses in the Eastern Mediterranean Region, 2005-2016. Infect Genet Evol. 2018 Oct 30;67:60-66..  Abstract  
submitted by kickingbird at 9 days ago from Infect Genet Evol. 2018 Oct 30;67:60-66. (via https://www.ncbi.nlm.nih.gov/pubmed/30389548)
BACKGROUND: Two classes of antiviral drugs are available for influenza antiviral therapy: the adamantanes and the neuraminidase inhibitors (NAIs). Due to the emergence of adamantane-resistant variants, ...

Nishisaka-Nonaka R. et al. Irradiation by ultraviolet light-emitting diodes inactivates influenza a viruses by inhibiting replication and transcription of viral RNA in host cells. J Photochem Photobiol B 2018.  Abstract  
submitted by kickingbird at 9 days ago from J Photochem Photobiol B 2018 (via https://www.ncbi.nlm.nih.gov/pubmed/30391908)
Influenza A viruses (IAVs) pose a serious global threat to humans and their livestock, especially poultry and pigs. This study aimed to investigate how to inactivate IAVs by using different ultraviolet-light-emitting ...

Nicol MQ, et al. Lack of IFNγ signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis. Virology. 2018 Oct 31;526:155-164.  Abstract  
submitted by kickingbird at 9 days ago from Virology. 2018 Oct 31;526:155-164 (via https://www.ncbi.nlm.nih.gov/pubmed/30390564)
IFNγ is a key regulator of inflammatory responses but its role in influenza A virus (IAV) pathogenesis is unclear. Our studies show that infection of mice lacking the IFNγ receptor (IFNγR-/-) at a dose ...

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