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2024-7-13 5:46:13
Article

Andreev K, Jones JC, Seiler P, Kandeil A, Webby RJ. Genotypic and phenotypic susceptibility of emerging avian influenza A viruses to neuraminidase and cap-dependent endonuclease inhibitors. Antiviral Res. 2024 Jul 8:105959.  Abstract  
submitted by kickingbird at 17 hours ago from Antiviral Res. 2024 Jul 8:105959 (via https://www.sciencedirect.com/science/article/pii/S016635422)
Avian influenza outbreaks, including ones caused by highly pathogenic A(H5N1) clade 2.3.4.4b viruses, have devastated animal populations and remain a threat to humans. Risk elements assessed for emerging ...

Ahrens AK, Pohlmann A, Grund C, Harder T, Beer M. Novel Genotypes of Highly Pathogenic Avian Influenza H5N1 Clade 2.3.4.4b Viruses, Germany, November 2023. Emerg Infect Dis. 2024 Aug.  Abstract  
submitted by kickingbird at 18 hours ago from Emerg Infect Dis. 2024 Aug (via https://wwwnc.cdc.gov/eid/article/30/8/24-0103_article)
Several subtypes and many different genotypes of highly pathogenic avian influenza viruses of subtype H5 clade 2.3.4.4b have repeatedly caused outbreaks in Germany. Four new highly pathogenic avian influenza ...

James J, Thomas SS, Seekings AH, Mahmood S, Kelly. Evaluating the epizootic and zoonotic threat of an H7N9 low-pathogenicity avian influenza virus (LPAIV) variant associated with enhanced pathogenicity in turkeys. J Gen Virol. 2024 Jul;105(7).  Abstract  
submitted by kickingbird at 3 days ago from J Gen Virol. 2024 Jul;105(7) (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Between 2013 and 2017, the A/Anhui/1/13-lineage (H7N9) low-pathogenicity avian influenza virus (LPAIV) was epizootic in chickens in China, causing mild disease, with 616 fatal human cases. Despite poultry ...

Yang Q, Ji J, Yang J, Zhang Y, Yin H, Dai H, Wang. Diversity of genotypes and pathogenicity of H9N2 avian influenza virus derived from wild bird and domestic poultry. Front. Microbiol. 15:1402235.  Abstract  
submitted by kickingbird at 4 days ago from Front. Microbiol. 15:1402235 (via https://www.frontiersin.org/journals/microbiology/articles/1)
Introduction: The H9N2 subtype is a predominant avian influenza virus (AIV) circulating in Chinese poultry, forming various genotypes (A-W) based on gene segment origins. This study aims to investigate ...

Eisfeld AJ, Biswas A, Guan L, Gu C, Maemura T, Tri. Pathogenicity and transmissibility of bovine H5N1 influenza virus. Nature. 2024 Jul 8.  Abstract  
submitted by kickingbird at 4 days ago from Nature. 2024 Jul 8 (via https://www.nature.com/articles/s41586-024-07766-6)
Highly pathogenic H5N1 avian influenza (HPAI H5N1) viruses occasionally infect, but typically do not transmit, in mammals. In the Spring of 2024, an unprecedented outbreak of HPAI H5N1 in bovine herds ...

Yuxin Guo, etc.,al. [preprint]An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts. https://doi.org/10.1101/2024.07.03.601996.  Abstract  
submitted by kickingbird at 4 days ago from https://doi.org/10.1101/2024.07.03.601996 (via https://www.biorxiv.org/content/10.1101/2024.07.03.601996v2)
Alterations in the PB2-627 domain could substantially increase the risk of an avian influenza virus (AIV) pandemic. So far, a well-known mammalian mutation PB2-E627K has not been maintained in AIV in poultry, ...

Wang X, Tang XE, Zheng H, Gao R, Lu X, Yang W, Zho. Amino acid mutations PB1-V719M and PA-N444D combined with PB2-627K contribute to the pathogenicity of H7N9 in mice. Vet Res. 2024 Jul 5;55(1):86.  Abstract  
submitted by kickingbird at 5 days ago from Vet Res. 2024 Jul 5;55(1):86 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
H7N9 subtype avian influenza viruses (AIVs) cause 1567 human infections and have high mortality, posing a significant threat to public health. Previously, we reported that two avian-derived H7N9 isolates ...

Adam S. Lauring, etc.,al. [preprint]Surveillance of H5 HPAI in Michigan using retail milk. https://doi.org/10.1101/2024.07.04.602115.  Abstract  
submitted by kickingbird at 5 days ago from https://doi.org/10.1101/2024.07.04.602115 (via https://www.biorxiv.org/content/10.1101/2024.07.04.602115v1)
An outbreak of highly pathogenic avian influenza virus (HPAI) H5N1 in dairy cattle in the United States has spread to at least 136 dairy herds in 11 states. Due to a lack of testing, it has been difficult ...

Isabela Carvalho Brcko, etc.,al. [preprint]Comprehensive Molecular Epidemiology of Influenza Viruses in Brazil: Insights from a Nationwide Analysis. https://doi.org/10.1101/2024.07.04.602044.  Abstract  
submitted by kickingbird at 5 days ago from https://doi.org/10.1101/2024.07.04.602044 (via https://www.biorxiv.org/content/10.1101/2024.07.04.602044v1)
Influenza A and B viruses pose significant global health threats, with substantial impacts on morbidity and mortality. Understanding their molecular epidemiology in Brazil, a key hub for the circulation ...

E Silva YC, Rezende PA, Lopes CEB, Lopes MC, Olive. Identification of sialic acid receptors for influenza A virus in snakes. J Comp Pathol. 2024 Jul 4;212:27-31.  Abstract  
submitted by kickingbird at 5 days ago from J Comp Pathol. 2024 Jul 4;212:27-31 (via https://www.sciencedirect.com/science/article/abs/pii/S00219)
The tissue tropism and the wide host range of influenza A viruses are determined by the presence of sialic acid (SA) α2,3-Gal and SA α2,6-Gal receptors. Recent studies have shown that animals possessing ...

Ciuoderis K, Usuga J, Pérez-Restrepo LS, Gonzalez-. Genomic diversity and evolutionary dynamics of Influenza A viruses in Colombian swine: implications for one health surveillance and control. Emerg Microbes Infect. 2024 Dec;13(1):2368202.  Abstract  
submitted by kickingbird at 5 days ago from Emerg Microbes Infect. 2024 Dec;13(1):2368202 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
Influenza A viruses (IAV) impose significant respiratory disease burdens in both swine and humans worldwide, with frequent human-to-swine transmission driving viral evolution in pigs and highlighting the ...

Yang F, Zhao X, Huo C, Miao X, Qin T, Chen S, Peng. An avian-origin internal backbone effectively increases the H5 subtype avian influenza vaccine candidate yield in both chicken embryonated eggs and MDCK cells. Poult Sci. 2024 Jun 18;103(9):103988.  Abstract  
submitted by kickingbird at 5 days ago from Poult Sci. 2024 Jun 18;103(9):103988 (via https://www.sciencedirect.com/science/article/pii/S003257912)
Inactivated vaccines play an important role in preventing and controlling the epidemic caused by the H5 subtype avian influenza virus. The vaccine strains are updated in response to alterations in surface ...

Panwar P, Jhala D, Tamrakar A, Joshi C, Patel A. Bacterially expressed full length Hemagglutinin of Avian Influenza Virus H5N1 forms oligomers and exhibits hemagglutination. Protein Expr Purif. 2024 Jul 4:106541.  Abstract  
submitted by kickingbird at 5 days ago from Protein Expr Purif. 2024 Jul 4:106541 (via https://www.sciencedirect.com/science/article/abs/pii/S10465)
Avian influenza poses a significant global health threat, with the potential for widespread pandemics and devastating consequences. Hemagglutinin (HA), a critical surface glycoprotein of influenza viruses, ...

Ge FF, Shen HX, Yang DQ, Yang XC, Li X, Wang J, Hu. The biological characteristics and infection dynamics of a novel H3N2 canine influenza virus genotype in beagles. Virol J. 2024 Jul 4;21(1):151.  Abstract  
submitted by kickingbird at 7 days ago from Virol J. 2024 Jul 4;21(1):151 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: The canine influenza virus (CIV) outbreak has garnered considerable attention as it poses a significant threat to dog health. During the H3N2 CIV evolution in beagles, the virus formed a new ...

Luchansky JB, C S Porto-Fett A, Suarez DL, Spackma. Inactivation of Avian Influenza Virus Inoculated into Ground Beef Patties Cooked on a Commercial Open-Flame Gas Grill. J Food Prot. 2024 Jul 2:100325.  Abstract  
submitted by kickingbird at 7 days ago from J Food Prot. 2024 Jul 2:100325 (via https://www.sciencedirect.com/science/article/pii/S0362028X2)
With the emergence of clade 2.3.4.4b H5N1 highly pathogenic avian influenza virus (AIV) infection of dairy cattle and its subsequent detection in raw milk, coupled with recent AIV infections affecting ...

Fan Yang, Xinyu Zhao, Chenzhi Huo, Xinyu Miao, Tao. An avian-origin internal backbone effectively increases the H5 subtype avian influenza vaccine candidate yield in both chicken embryonated eggs and MDCK cells. Poultry Science,2024,103988.  Abstract  
submitted by kickingbird at 9 days ago from Poultry Science,2024,103988 (via https://www.sciencedirect.com/science/article/pii/S003257912)
Inactivated vaccines play an important role in preventing and controlling the epidemic caused by the H5 subtype avian influenza virus. The vaccine strains are updated in response to alterations in surface ...

Liang, Z., Lin, X., Sun, L. et al. A(H2N2) and A(H3N2) influenza pandemics elicited durable cross-reactive and protective antibodies against avian N2 neuraminidases. Nat Commun 15, 5593 (2024).  Abstract  
submitted by kickingbird at 9 days ago from Nat Commun 15, 5593 (2024) (via https://www.nature.com/articles/s41467-024-49884-9)
Human cases of avian influenza virus (AIV) infections are associated with an age-specific disease burden. As the influenza virus N2 neuraminidase (NA) gene was introduced from avian sources during the ...

Chen W, Gu Y, Ma Y, Dong L, Pan L, Ji C, Guo L, Qi. Profiling lipid mediators in serum from children with H1N1 influenza. Sci Rep. 2024 Jul 2;14(1):15186.  Abstract  
submitted by kickingbird at 9 days ago from Sci Rep. 2024 Jul 2;14(1):15186 (via https://www.nature.com/articles/s41598-024-66190-y)
Influenza A virus subtype H1N1 can cause severe acute respiratory distress syndrome and death in young children and elderly individuals. H1N1 initiates inflammatory responses that aim to contain and eliminate ...

de Carvalho Araujo A, Cho AY, Silva LMN, Corrêa TC. Mortality in sea lions is associated with the introduction of the H5N1 clade 2.3.4.4b virus in Brazil October 2023: whole genome sequencing and phylogenetic analysis. BMC Vet Res. 2024 Jul 2;20(1):285.  Abstract  
submitted by kickingbird at 9 days ago from BMC Vet Res. 2024 Jul 2;20(1):285 (via https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-)
Clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 virus was detected in the South American sea lions found dead in Santa Catarina, Brazil, in October 2023. Whole genome sequencing and comparative ...

Spackman E, Jones DR, McCoig AM, Colonius TJ, Gora. Characterization of highly pathogenic avian influenza virus in retail dairy products in the US. J Virol. 2024 Jul 3:e0088124.  Abstract  
submitted by kickingbird at 9 days ago from J Virol. 2024 Jul 3:e0088124 (via https://journals.asm.org/doi/10.1128/jvi.00881-24)
In March 2024, clade 2.3.4.4b H5N1 highly pathogenic avian influenza virus (HPAIV) was detected in dairy cattle in the US, and it was discovered that the virus could be detected in raw milk. Although affected ...

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