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2019-12-8 1:22:28
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Pascua PNQ, et al. Influenza B viruses from different genetic backgrounds are variably impaired by neuraminidase inhibitor resistance-associated substitutions. Antiviral Res. 2019 Nov 29:104669..  Abstract  
submitted by kickingbird at 14 hours ago from Antiviral Res. 2019 Nov 29:104669. (via https://www.sciencedirect.com/science/article/pii/S016635421)
Identifying evolutionary routes to antiviral resistance among influenza viruses informs molecular-based resistance surveillance and clinical decisions. To improve antiviral management and understand whether ...

Imai M, et al. Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets. Nat Microbiol. 2019 Nov 25..  Abstract  
submitted by kickingbird at 14 hours ago from Nat Microbiol. 2019 Nov 25. (via https://www.nature.com/articles/s41564-019-0609-0)
Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein-a mutation that confers reduced susceptibility ...

Bogdanow B, et al. The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant. Nat Commun. 2019 Dec 4;10(1):5518.  Abstract  
submitted by kickingbird at 14 hours ago from Nat Commun. 2019 Dec 4;10(1):5518 (via https://www.nature.com/articles/s41467-019-13520-8)
Pandemic influenza A virus (IAV) outbreaks occur when strains from animal reservoirs acquire the ability to infect and spread among humans. The molecular basis of this species barrier is incompletely understood. ...

Chiapponi C, et al. Detection of a New Genetic Cluster of Influenza D Virus in Italian Cattle. Viruses. 2019 Nov 30;11(12)..  Abstract  
submitted by kickingbird at 14 hours ago from Viruses. 2019 Nov 30;11(12). (via https://www.mdpi.com/1999-4915/11/12/1110)
Influenza D virus (IDV) has been increasingly reported all over the world. Cattle are considered the major viral reservoir. Based on the hemagglutinin-esterase (HEF) gene, three main genetic and antigenic ...

Zhong G, et al. Mutations in the NA-like protein of bat influenza H18N11 virus enhance virus replication in mammalian cells, mice, and ferrets. J Virol. 2019 Dec 4.  Abstract  
submitted by kickingbird at 14 hours ago from J Virol. 2019 Dec 4 (via https://jvi.asm.org/content/early/2019/11/28/JVI.01416-19)
To characterize bat influenza H18N11 virus, we propagated a reverse genetics-generated H18N11 virus in MDCK II cells and detected two adapting mutations in the neuraminidase (NA)-like protein (NA-F144C ...

Valesano AL, et al. Influenza B viruses exhibit lower within-host diversity than influenza A viruses in human hosts. J Virol. 2019 Dec 4.  Abstract  
submitted by kickingbird at 14 hours ago from J Virol. 2019 Dec 4 (via https://jvi.asm.org/content/early/2019/11/28/JVI.01710-19)
Influenza B virus undergoes seasonal antigenic drift more slowly than influenza A, but the reasons for this difference are unclear. While the evolutionary dynamics of influenza viruses play out globally, ...

Shi L, et al. Molecular evolution and amino acid characteristics of newly isolated H9N2 avian influenza viruses from Liaoning Province, China. J Vet Med Sci. 2019 Dec 4..  Abstract  
submitted by kickingbird at 14 hours ago from J Vet Med Sci. 2019 Dec 4. (via https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_19)
H9N2 is widespread among poultry and humans. Though this subtype is not lethal to either species, it can cause considerable financial losses for farmers and threaten human health. In this study, 10 new ...

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