Feldstein LR, Self WH, Ferdinands JM, Randolph AG,. Incorporating real-time influenza detection into the test-negative design for estimating influenza vaccine effectiveness: The real-time test-negative design (rtTND). Clin Infect Dis. 2020 Sep 25:ciaa1453.. Abstract
submitted by kickingbird at 15 hours ago from Clin Infect Dis. 2020 Sep 25:ciaa1453. (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
With rapid and accurate molecular influenza testing now widely available in clinical settings, influenza vaccine effectiveness (VE) studies can prospectively select participants for enrollment based on ...
Frank K, Paust S. Dynamic Natural Killer Cell and T Cell Responses to Influenza Infection. Front Cell Infect Microbiol. 2020 Aug 18;10:425. Abstract
submitted by kickingbird at 15 hours ago from Front Cell Infect Microbiol. 2020 Aug 18;10:425 (via https://www.frontiersin.org/articles/10.3389/fcimb.2020.0042)
Influenza viruses have perplexed scientists for over a hundred years. Yearly vaccines limit their spread, but they do not prevent all infections. Therapeutic treatments for those experiencing severe infection ...
Mostafa A, Mahmoud SH, Shehata M, Müller C, Kandei. PA from a Recent H9N2 (G1-Like) Avian Influenza a Virus (AIV) Strain Carrying Lysine 367 Confers Altered Replication Efficiency and Pathogenicity to Contemporaneous H5N1 in Mammalian Systems. Viruses. 2020 Sep 20;12(9):E1046. Abstract
submitted by kickingbird at 3 days ago from Viruses. 2020 Sep 20;12(9):E1046 (via https://pubmed.ncbi.nlm.nih.gov/32962203/)
Egypt is a hotspot for H5- and H9-subtype avian influenza A virus (AIV) infections and co-infections in poultry by both subtypes have been frequently reported. However, natural genetic reassortment of ...
Declercq M, Biquand E, Karim M, Pietrosemoli N, Ja. Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription. Nucleic Acids Res. 2020 Sep 22:gkaa771. Abstract
submitted by kickingbird at 3 days ago from Nucleic Acids Res. 2020 Sep 22:gkaa771 (via https://academic.oup.com/nar/advance-article/doi/10.1093/nar)
Cellular exonucleases involved in the processes that regulate RNA stability and quality control have been shown to restrict or to promote the multiplication cycle of numerous RNA viruses. Influenza A viruses ...
Li K, McCaw JM, Cao P. Modelling within-host macrophage dynamics in influenza virus infection. J Theor Biol. 2020 Sep 20:110492. Abstract
submitted by kickingbird at 3 days ago from J Theor Biol. 2020 Sep 20:110492 (via https://www.sciencedirect.com/science/article/abs/pii/S00225)
Human respiratory disease associated with influenza virus infection is of significant public health concern. Macrophages, as part of the front line of host innate cellular defence, have been shown to play ...
King J, Harder T, Conraths FJ, Beer M, Pohlmann A. The Genetics of Highly Pathogenic Avian Influenza Viruses of Subtype H5 in Germany, 2006~2020. Transbound Emerg Dis. 2020 Sep 22. Abstract
submitted by kickingbird at 3 days ago from Transbound Emerg Dis. 2020 Sep 22 (via https://pubmed.ncbi.nlm.nih.gov/32964686/)
The H5 A/Goose/Guangdong/1/1996 (gs/GD) lineage emerged in China in 1996. Rooted in the respective gs/GD lineage, the hemagglutinin (HA) gene of highly pathogenic avian influenza viruses (HPAIV) has genetically ...
Jones TE. Oseltamivir - Current dosing recommendations reduce the therapeutic benefit in patients with mild to moderate renal function and/or large body mass. A review of the literature with recommendations to. her Drug Monit. 2020;10.1097/FTD.0000000000000797. Abstract
submitted by kickingbird at 6 days ago from her Drug Monit. 2020;10.1097/FTD.0000000000000797 (via https://pubmed.ncbi.nlm.nih.gov/32947554/)
Purpose: Oseltamivir is indicated for the treatment and prophylaxis of Influenza infections. Achieving therapeutic concentrations EARLY in the course of the infection impacts greatly on the magnitude of ...
Tang L, Tang W, Li X, et al. Avian Influenza Virus Prevalence and Subtype Diversity in Wild Birds in Shanghai, China, 2016-2018. Viruses. 2020;12(9):E1031. Abstract
submitted by kickingbird at 6 days ago from Viruses. 2020;12(9):E1031 (via https://www.mdpi.com/1999-4915/12/9/1031)
From 2016 to 2018, surveillance of influenza A viruses in wild birds was conducted in Shanghai, located at the East Asian-Australian flyway, China. A total of 5112 samples from 51 species of wild birds ...
Olsen SJ, Azziz-Baumgartner E, Budd AP, et al. Decreased Influenza Activity During the COVID-19 Pandemic — United States, Australia, Chile, and South Africa, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(37):1305-1309. Abstract
submitted by kickingbird at 8 days ago from MMWR Morb Mortal Wkly Rep. 2020;69(37):1305-1309 (via https://www.cdc.gov/mmwr/volumes/69/wr/mm6937a6.htm)
After recognition of widespread community transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), by mid- to late February 2020, indicators of influenza activity began to ...
Zhu Y, Wang R, Yu L, et al. Human TRA2A determines influenza A virus host adaptation by regulating viral mRNA splicing. Sci Adv. 2020;6(25):eaaz5764. Abstract
submitted by kickingbird at 8 days ago from Sci Adv. 2020;6(25):eaaz5764 (via https://advances.sciencemag.org/content/6/25/eaaz5764)
Several avian influenza A viruses (IAVs) have adapted to mammalian species, including humans. To date, the mechanisms enabling these host shifts remain incompletely understood. Here, we show that a host ...
Caliendo V, Leijten L, Begeman L, et al. Enterotropism of highly pathogenic avian influenza virus H5N8 from the 2016/2017 epidemic in some wild bird species. Vet Res. 2020;51(1):117. Abstract
submitted by kickingbird at 10 days ago from Vet Res. 2020;51(1):117 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
In 2016/2017, H5N8 highly pathogenic avian influenza (HPAI) virus of the Goose/Guangdong lineage spread from Asia to Europe, causing the biggest and most widespread HPAI epidemic on record in wild and ...
Bruce-Staskal PJ, Woods RM, Borisov OV, Massare MJ. Hemagglutinin from multiple divergent influenza A and B viruses bind to a distinct branched, sialylated poly-LacNAc glycan by surface plasmon resonance. Vaccine. 2020;S0264-410X(20)31078-1. Abstract
submitted by kickingbird at 10 days ago from Vaccine. 2020;S0264-410X(20)31078-1 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Influenza viruses initiate infection via specific interactions of hemagglutinin (HA) with host cell surface sialic acid-containing glycans. Antigenic drift has resulted in HA amino acid sequence changes ...
Liu WJ, Wu Y, Bi Y, et al.. Emerging HxNy Influenza A Viruses. Cold Spring Harb Perspect Med. 2020;a038406. Abstract
submitted by kickingbird at 10 days ago from Cold Spring Harb Perspect Med. 2020;a038406 (via http://perspectivesinmedicine.cshlp.org/content/early/2020/0)
The continuous emergence and reemergence of diverse subtypes of influenza A viruses, which are known as "HxNy" and are mediated through the reassortment of viral genomes, account for seasonal epidemics, ...
Xia J, Kuang Y, Liang J, Jones M, Swain SL. Influenza Vaccine-Induced CD4 Effectors Require Antigen Recognition at an Effector Checkpoint to Generate CD4 Lung Memory and Antibody Production. J Immunol. 2020;ji2000597. Abstract
submitted by kickingbird at 10 days ago from J Immunol. 2020;ji2000597 (via https://www.jimmunol.org/content/early/2020/09/12/jimmunol.2)
Previously, we discovered that influenza-generated CD4 effectors must recognize cognate Ag at a defined effector checkpoint to become memory cells. Ag recognition was also required for efficient protection ...
Boussier J, Munier S, Achouri E, et al. RNA-seq accuracy and reproducibility for the mapping and quantification of influenza defective viral genomes. RNA. 2020;rna.077529.120. Abstract
submitted by kickingbird at 10 days ago from RNA. 2020;rna.077529.120 (via https://rnajournal.cshlp.org/content/early/2020/09/14/rna.07)
Like most RNA viruses, influenza viruses generate defective viral genomes (DVGs) with large internal deletions during replication. There is accumulating evidence supporting a biological relevance of such ...
Watkins LC, DeGrado WF, Voth GA. Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics. J Am Chem Soc. 2020;10.1021/jacs.0c06419.. Abstract
submitted by kickingbird at 10 days ago from J Am Chem Soc. 2020;10.1021/jacs.0c06419. (via https://pubs.acs.org/doi/10.1021/jacs.0c06419)
Prevalent resistance to inhibitors that target the influenza A M2 proton channel has necessitated a continued drug design effort, supported by a sustained study of the mechanism of channel function and ...
Ruiz S, Jimenez-Bluhm P, Di Pillo F, et al. Temporal dynamics and the influence of environmental variables on the prevalence of avian influenza virus in main wetlands in central chile. Transbound Emerg Dis. 2020;10.1111/tbed.13831. Abstract
submitted by kickingbird at 10 days ago from Transbound Emerg Dis. 2020;10.1111/tbed.13831 (via https://pubmed.ncbi.nlm.nih.gov/32931631/)
Although wild birds are considered the main reservoir of the influenza A virus (IAV) in nature, empirical investigations exploring the interaction between the IAV prevalence in these populations and environmental ...
Steiner F, Pavlovic J. Subcellular localization of MxB determines its antiviral potential against influenza A virus. J Virol. 2020;JVI.00125-20. Abstract
submitted by kickingbird at 13 days ago from J Virol. 2020;JVI.00125-20 (via https://jvi.asm.org/content/early/2020/09/03/JVI.00125-20)
Mx proteins are interferon (IFN) type I (α/β) and type III (λ) induced effector proteins with intrinsic antiviral activity. Mammalian Mx proteins show different subcellular localizations and distinct yet ...
Liu Z, Geng X, Cui Z, Li W, Ou X, Liao G. Construction and identification of influenza plasmid pool imparting high yields to candidate vaccine viruses in Vero cell at low temperature. J Cell Mol Med. 2020;10.1111/jcmm.15672. Abstract
submitted by kickingbird at Sep, 11, 2020 from J Cell Mol Med. 2020;10.1111/jcmm.15672 (via https://pubmed.ncbi.nlm.nih.gov/32902192/)
We generated plasmid pools for the rapid preparation of candidate vaccine strains, which could grow in the Vero cells at low temperature. Firstly, we cloned in the pHW2000 plasmid each of the eight gene ...
Peukes J, Xiong X, Erlendsson S, et al. The native structure of the assembled matrix protein 1 of influenza A virus. Nature. 2020;10.1038/s41586-020-2696-8. Abstract
submitted by kickingbird at Sep, 11, 2020 from Nature. 2020;10.1038/s41586-020-2696-8 (via https://www.nature.com/articles/s41586-020-2696-8)
Influenza A virus causes millions of severe cases of disease during annual epidemics. The most abundant protein in influenza virions is matrix protein 1 (M1), which mediates virus assembly by forming an ...
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