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2020-7-7 4:19:08
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Scolamacchia F, Mulatti P, Mazzucato M, et al. Different Environmental Gradients Associated to the Spatiotemporal and Genetic Pattern of the H5N8 Highly Pathogenic Avian Influenza Outbreaks in Poultry in Italy. Transbound Emerg Dis. 2020;10.1111/tbed.13661.  Abstract  
submitted by kickingbird at 4 days ago from Transbound Emerg Dis. 2020;10.1111/tbed.13661 (via https://pubmed.ncbi.nlm.nih.gov/32613724/)
Comprehensive understanding of the patterns and drivers of avian influenza outbreaks is pivotal to inform surveillance systems and heighten nations' ability to quickly detect and respond to the emergence ...

Zeng Z, Yau LF, Lin Z, et al. Characterization and Evolutionary Analysis of a Novel H3N2 Influenza A Virus Glycosylation Motif in Southern China. Front Microbiol. 2020;11:1318.  Abstract  
submitted by kickingbird at 4 days ago from Front Microbiol. 2020;11:1318 (via https://pubmed.ncbi.nlm.nih.gov/32612596/)
An influenza A (H3N2) virus epidemic occurred in China in 2017 and the causative strain failed to bind red blood cells (RBCs), which may affect receptor binding and antibody recognition. The objective ...

Belser JA, Sun X, Brock N, et al. Genetically and Antigenically Divergent Influenza A(H9N2) Viruses Exhibit Differential Replication and Transmission Phenotypes in Mammalian Models. J Virol. 2020;JVI.00451-20.  Abstract  
submitted by kickingbird at 4 days ago from J Virol. 2020;JVI.00451-20 (via https://pubmed.ncbi.nlm.nih.gov/32611751/)
Low pathogenicity avian influenza A(H9N2) viruses, enzootic in poultry populations in Asia, are associated with fewer confirmed human infections but higher rates of seropositivity compared to A(H5) or ...

Zhang RH, Li PY, Xu MJ, et al. Molecular Characterization and Pathogenesis of H9N2 Avian Influenza Virus Isolated From a Racing Pigeon. Vet Microbiol. 2020;246:108747.  Abstract  
submitted by kickingbird at 5 days ago from Vet Microbiol. 2020;246:108747 (via https://pubmed.ncbi.nlm.nih.gov/32605760/)
H9N2 avian influenza viruses (AIVs) can cross species barriers and expand from birds tomammals and humans. It usually leads to economic loss for breeding farms and poses a serious threat to human health.This ...

Chen Z, Wang Z, Zhao X, et al. Pathogenicity of Different H5N6 Highly Pathogenic Avian Influenza Virus Strains and Host Immune Responses in Chickens. Vet Microbiol. 2020;246:108745.  Abstract  
submitted by kickingbird at 5 days ago from Vet Microbiol. 2020;246:108745 (via https://pubmed.ncbi.nlm.nih.gov/32605756/)
The H5N6 highly pathogenic avian influenza virus (HPAIV) has been circulating in China since 2013. In this report, we describe our recent chicken experimental studies investigating the pathogenicity and ...

Ruan BY, Yao Y, Wang SY, et al. Protective Efficacy of a Bivalent Inactivated Reassortant H1N1 Influenza Virus Vaccine Against European Avian-Like and Classical Swine Influenza H1N1 Viruses in Mice. Vet Microbiol. 2020;246:108724.  Abstract  
submitted by kickingbird at 5 days ago from Vet Microbiol. 2020;246:108724 (via https://pubmed.ncbi.nlm.nih.gov/32605742/)
The classical swine (CS) H1N1 swine influenza virus (SIVs) emerged in humans as a reassortant virus that caused the H1N1 influenza virus pandemic in 2009, and the European avian-like (EA) H1N1 SIVs has ...

Dos Anjos Borges LG, Pisanelli G, Khatun O, García. Live Visualization of Hemagglutinin Dynamics During Infection by Using a Novel Reporter Influenza A Virus. Viruses. 2020;12(6):E687.  Abstract  
submitted by kickingbird at 5 days ago from Viruses. 2020;12(6):E687 (via https://pubmed.ncbi.nlm.nih.gov/32604762/)
Live visualization of influenza A virus (IAV) structural proteins during viral infection in cells is highly sought objective to study different aspects of the viral replication cycle. To achieve this, ...

Hu M, Yang G, DeBeauchamp J, et al. HA Stabilization Promotes Replication and Transmission of Swine H1N1 Gamma Influenza Viruses in Ferrets. Elife. 2020;9:e56236..  Abstract  
submitted by kickingbird at 5 days ago from Elife. 2020;9:e56236. (via https://pubmed.ncbi.nlm.nih.gov/32602461/)
Pandemic influenza A viruses can emerge from swine, an intermediate host that supports adaptation of human-preferred receptor-binding specificity by the hemagglutinin (HA) surface antigen. Other HA traits ...

Hu Z, Shi L, Xu N, et al. Induction of Cross-Group Broadly Reactive Antibody Response by Natural H7N9 Avian Influenza Virus Infection and Immunization With Inactivated H7N9 Vaccine in Chickens. Transbound Emerg Dis. 2020;10.1111/tbed.13705.  Abstract  
submitted by kickingbird at 5 days ago from Transbound Emerg Dis. 2020;10.1111/tbed.13705 (via https://pubmed.ncbi.nlm.nih.gov/32602258/)
Pre-existing immunity against the conserved hemagglutinin (HA) stalk underlies the elicitation of cross-group antibody induced by natural H7N9 virus infection and immunization in humans. However, whether ...

Park JK, Xiao Y, Ramuta MD, et al. Pre-existing Immunity to Influenza Virus Hemagglutinin Stalk Might Drive Selection for Antibody-Escape Mutant Viruses in a Human Challenge Model. Nat Med. 2020;10.1038/s41591-020-0937-x.  Abstract  
submitted by kickingbird at 5 days ago from Nat Med. 2020;10.1038/s41591-020-0937-x (via https://pubmed.ncbi.nlm.nih.gov/32601336/)
The conserved region of influenza hemagglutinin (HA) stalk (or stem) has gained attention as a potent target for universal influenza vaccines1-5. Although the HA stalk region is relatively well conserved, ...

Le Sage V, Kanarek JP, Snyder DJ, Cooper VS, Lakda. Mapping of Influenza Virus RNA-RNA Interactions Reveals a Flexible Network. Cell Rep. 2020;31(13):107823.  Abstract  
submitted by kickingbird at 5 days ago from Cell Rep. 2020;31(13):107823 (via https://pubmed.ncbi.nlm.nih.gov/32610124/)
Selective assembly of influenza virus segments into virions is proposed to be mediated through intersegmental RNA-RNA interactions. Here, we developed a method called 2CIMPL that includes proximity ligation ...

Ruan T, Sun J, Liu W, et al. H1N1 Influenza Virus Cross-Activates Gli1 to Disrupt the Intercellular Junctions of Alveolar Epithelial Cells. Cell Rep. 2020;31(13):107801.  Abstract  
submitted by kickingbird at 5 days ago from Cell Rep. 2020;31(13):107801
Influenza A virus (IAV) primarily infects the airway and alveolar epithelial cells and disrupts the intercellular junctions, leading to increased paracellular permeability. Although this pathological change ...

Sevy AM, Gilchuk IM, Brown BP, et al. Computationally Designed Cyclic Peptides Derived From an Antibody Loop Increase Breadth of Binding for Influenza Variants. Structure. 2020;S0969-2126(20)30124-6.  Abstract  
submitted by kickingbird at 5 days ago from Structure. 2020;S0969-2126(20)30124-6 (via https://pubmed.ncbi.nlm.nih.gov/32610044/)
The influenza hemagglutinin (HA) glycoprotein is the target of many broadly neutralizing antibodies. However, influenza viruses can rapidly escape antibody recognition by mutation of hypervariable regions ...

Jansen AJG, Spaan T, Low HZ, et al. Influenza-induced Thrombocytopenia Is Dependent on the Subtype and Sialoglycan Receptor and Increases With Virus Pathogenicity. Blood Adv. 2020;4(13):2967-2978.  Abstract  
submitted by kickingbird at 5 days ago from Blood Adv. 2020;4(13):2967-2978 (via https://pubmed.ncbi.nlm.nih.gov/32609845/)
Thrombocytopenia is a common complication of influenza virus infection, and its severity predicts the clinical outcome of critically ill patients. The underlying cause(s) remain incompletely understood. ...

HL Sun, et al. Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection. PNAS first published June 29, 2020.  Abstract  
submitted by kickingbird at 7 days ago from PNAS first published June 29, 2020 (via https://www.pnas.org/content/early/2020/06/23/1921186117)
Pigs are considered as important hosts or “mixing vessels” for the generation of pandemic influenza viruses. Systematic surveillance of influenza viruses in pigs is essential for early warning and preparedness ...

Schofield C, Colombo RE, Richard SA, et al. Comparable Disease Severity by Influenza Virus Subtype in the Acute Respiratory Infection Consortium Natural History Study. Mil Med. 2020;usaa120..  Abstract  
submitted by kickingbird at 7 days ago from Mil Med. 2020;usaa120. (via https://pubmed.ncbi.nlm.nih.gov/32588899/)
Introduction: Since the influenza A/H1N1 pandemic of 2009 to 2010, numerous studies have described the clinical course and outcome of the different subtypes of influenza (A/H1N1, A/H3N2, and B). A recent ...

Nüssing S, Mifsud E, Hensen L, et al. Viral Burden, Inflammatory Milieu and CD8 + T-cell Responses to Influenza Virus in a Second-Generation Thiazolide (RM-5061) and Oseltamivir Combination Therapy Study. Influenza Other Respir Viruses. 2020;10.1111/irv.1.  Abstract  
submitted by kickingbird at 7 days ago from Influenza Other Respir Viruses. 2020;10.1111/irv.1 (via https://pubmed.ncbi.nlm.nih.gov/32588557/)
Background: Influenza viruses cause significant morbidity and mortality, especially in young children, elderly, pregnant women and individuals with co-morbidities. Patients with severe influenza disease ...

Zhu Y, Wang R, Yu L, et al. Human TRA2A Determines Influenza A Virus Host Adaptation by Regulating Viral mRNA Splicing. Sci Adv. 2020;6(25):eaaz5764.  Abstract  
submitted by kickingbird at 7 days ago from Sci Adv. 2020;6(25):eaaz5764 (via https://pubmed.ncbi.nlm.nih.gov/32596447/)
Several avian influenza A viruses (IAVs) have adapted to mammalian species, including humans. To date, the mechanisms enabling these host shifts remain incompletely understood. Here, we show that a host ...

Zu S, Xue Q, He Z, et al. Duck PIAS2 Promotes H5N1 Avian Influenza Virus Replication Through Its SUMO E3 Ligase Activity. Front Microbiol. 2020;11:1246.  Abstract  
submitted by kickingbird at 7 days ago from Front Microbiol. 2020;11:1246 (via https://pubmed.ncbi.nlm.nih.gov/32595623/)
The protein inhibitor of the activated STAT2 (PIAS2) has been implicated in many cellular processes and can also regulate viral replication in mammals. However, the role of PIAS2 in the highly pathogenic ...

McCuen MM, Pitesky ME, Buler JJ, et al. A Comparison of Amplification Methods to Detect Avian Influenza Viruses in California Wetlands Targeted via Remote Sensing of Waterfowl. Transbound Emerg Dis. 2020;10.1111/tbed.13612.  Abstract  
submitted by kickingbird at 7 days ago from Transbound Emerg Dis. 2020;10.1111/tbed.13612 (via https://pubmed.ncbi.nlm.nih.gov/32592444/)
Migratory waterfowl, including geese and ducks, are indicated as the primary reservoir of avian influenza viruses (AIv) which can be subsequently spread to commercial poultry. The US Department of Agriculture's ...

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