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2019-12-8 0:53:20
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Pascua PNQ, et al. Influenza B viruses from different genetic backgrounds are variably impaired by neuraminidase inhibitor resistance-associated substitutions. Antiviral Res. 2019 Nov 29:104669..  Abstract  
submitted by kickingbird at 14 hours ago from Antiviral Res. 2019 Nov 29:104669. (via https://www.sciencedirect.com/science/article/pii/S016635421)
Identifying evolutionary routes to antiviral resistance among influenza viruses informs molecular-based resistance surveillance and clinical decisions. To improve antiviral management and understand whether ...

Imai M, et al. Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets. Nat Microbiol. 2019 Nov 25..  Abstract  
submitted by kickingbird at 14 hours ago from Nat Microbiol. 2019 Nov 25. (via https://www.nature.com/articles/s41564-019-0609-0)
Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein-a mutation that confers reduced susceptibility ...

Bogdanow B, et al. The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant. Nat Commun. 2019 Dec 4;10(1):5518.  Abstract  
submitted by kickingbird at 14 hours ago from Nat Commun. 2019 Dec 4;10(1):5518 (via https://www.nature.com/articles/s41467-019-13520-8)
Pandemic influenza A virus (IAV) outbreaks occur when strains from animal reservoirs acquire the ability to infect and spread among humans. The molecular basis of this species barrier is incompletely understood. ...

Chiapponi C, et al. Detection of a New Genetic Cluster of Influenza D Virus in Italian Cattle. Viruses. 2019 Nov 30;11(12)..  Abstract  
submitted by kickingbird at 14 hours ago from Viruses. 2019 Nov 30;11(12). (via https://www.mdpi.com/1999-4915/11/12/1110)
Influenza D virus (IDV) has been increasingly reported all over the world. Cattle are considered the major viral reservoir. Based on the hemagglutinin-esterase (HEF) gene, three main genetic and antigenic ...

Zhong G, et al. Mutations in the NA-like protein of bat influenza H18N11 virus enhance virus replication in mammalian cells, mice, and ferrets. J Virol. 2019 Dec 4.  Abstract  
submitted by kickingbird at 14 hours ago from J Virol. 2019 Dec 4 (via https://jvi.asm.org/content/early/2019/11/28/JVI.01416-19)
To characterize bat influenza H18N11 virus, we propagated a reverse genetics-generated H18N11 virus in MDCK II cells and detected two adapting mutations in the neuraminidase (NA)-like protein (NA-F144C ...

Valesano AL, et al. Influenza B viruses exhibit lower within-host diversity than influenza A viruses in human hosts. J Virol. 2019 Dec 4.  Abstract  
submitted by kickingbird at 14 hours ago from J Virol. 2019 Dec 4 (via https://jvi.asm.org/content/early/2019/11/28/JVI.01710-19)
Influenza B virus undergoes seasonal antigenic drift more slowly than influenza A, but the reasons for this difference are unclear. While the evolutionary dynamics of influenza viruses play out globally, ...

Shi L, et al. Molecular evolution and amino acid characteristics of newly isolated H9N2 avian influenza viruses from Liaoning Province, China. J Vet Med Sci. 2019 Dec 4..  Abstract  
submitted by kickingbird at 14 hours ago from J Vet Med Sci. 2019 Dec 4. (via https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_19)
H9N2 is widespread among poultry and humans. Though this subtype is not lethal to either species, it can cause considerable financial losses for farmers and threaten human health. In this study, 10 new ...

Chowdhury S, et al. The Pattern of Highly Pathogenic Avian Influenza H5N1 Outbreaks in South Asia. Trop Med Infect Dis. 2019 Nov 27;4(4)..  Abstract  
submitted by kickingbird at 5 days ago from Trop Med Infect Dis. 2019 Nov 27;4(4). (via https://www.mdpi.com/2414-6366/4/4/138)
Highly pathogenic avian influenza (HPAI) H5N1 has caused severe illnesses in poultry and in humans. More than 15,000 outbreaks in domestic birds from 2005 to 2018 and 861 human cases from 2003 to 2019 ...

Ilyushina NA, et al. Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies. Virol J. 2019 Nov 29;16(1):149.  Abstract  
submitted by kickingbird at 5 days ago from Virol J. 2019 Nov 29;16(1):149 (via https://www.ncbi.nlm.nih.gov/pubmed/31783761)
BACKGROUND: Vaccination and the use of neuraminidase inhibitors (NAIs) are currently the front lines of defense against seasonal influenza. The activity of influenza vaccines and antivirals drugs such ...

Mastrolia MV, Rubino C, Resti M, Trapani S, Galli. Characteristics and outcome of influenza-associated encephalopathy/encephalitis among children in a tertiary pediatric hospital in Italy, 2017-2019. BMC Infect Dis. 2019 Nov 29;19(1):1012.  Abstract  
submitted by kickingbird at 5 days ago from BMC Infect Dis. 2019 Nov 29;19(1):1012 (via https://www.ncbi.nlm.nih.gov/pubmed/31783806)
BACKGROUND: Influenza is the most frequent cause of acute upper respiratory tract infections during winter season. Although rare, neurological manifestations are known to occur during influenza infection ...

Hibbs BF, et al. Reports of atypical shoulder pain and dysfunction following inactivated influenza vaccine, Vaccine Adverse Event Reporting System (VAERS), 2010-2017. Vaccine. 2019 Nov 26..  Abstract  
submitted by kickingbird at 5 days ago from Vaccine. 2019 Nov 26. (via https://www.ncbi.nlm.nih.gov/pubmed/31784231)
BACKGROUND: Vaccines administered into or too close to underlying joint structures have the potential to cause shoulder injuries. Limited data exist on the epidemiology of such events.OBJECTIVE: To describe ...

Zhang Y, Yu T, Ding Y, Li Y, Lei J, Hu B, Zhou J. Analysis of Expression Profiles of Long Noncoding RNAs and mRNAs in A549 Cells Infected with H3N2 Swine Influenza Virus by RNA Sequencing. Virol Sin. 2019 Nov 27..  Abstract  
submitted by kickingbird at 7 days ago from Virol Sin. 2019 Nov 27. (via https://www.ncbi.nlm.nih.gov/pubmed/31777011)
Long noncoding RNAs (lncRNAs) participate in regulating many biological processes. However, their roles in influenza A virus (IAV) pathogenicity are largely unknown. Here, we analyzed the expression profiles ...

Oliva J, et al. A murine model for the study of influenza D virus. J Virol. 2019 Nov 27..  Abstract  
submitted by kickingbird at 7 days ago from J Virol. 2019 Nov 27. (via https://jvi.asm.org/content/early/2019/11/21/JVI.01662-19)
A novel genus within the Orthomyxoviridae family was identified in the USA and named Influenza D virus (IDV). Bovine have been proposed to be the primary host and three main viral lineages (D/OK-like, ...

Rodriguez-Frandsen A, et al. Viral determinants in H5N1 influenza A virus enable productive infection of HeLa cells. J Virol. 2019 Nov 27.  Abstract  
submitted by kickingbird at 7 days ago from J Virol. 2019 Nov 27 (via https://jvi.asm.org/content/early/2019/11/21/JVI.01410-19)
Influenza A virus (IAV) is a human respiratory pathogen that causes yearly global epidemics, and sporadic pandemics due to human adaptation of pathogenic strains. Efficient replication of IAV in different ...

Karakus U, Pohl MO, Stertz S. Breaking the convention: Sialoglycan variants, Co-receptors and Alternative Receptors for Influenza A Virus Entry. J Virol. 2019 Nov 27..  Abstract  
submitted by kickingbird at 7 days ago from J Virol. 2019 Nov 27. (via https://jvi.asm.org/content/early/2019/11/21/JVI.01357-19)
The influenza A virus (IAV) envelope protein haemagglutinin binds α2,6- or α2,3-linked sialic acid as host cell receptor. Bat IAV subtypes H17N10 and H18N11 form an exception to this rule and do not bind ...

Ding X, Yuan X, Mao L, Wu A, Jiang T. FluReassort: a database for the study of genomic reassortments among influenza viruses. Brief Bioinform. 2019 Nov 27.  Abstract  
submitted by kickingbird at 7 days ago from Brief Bioinform. 2019 Nov 27 (via https://academic.oup.com/bib/advance-article-abstract/doi/10)
Genomic reassortment is an important genetic event in the generation of emerging influenza viruses, which can cause numerous serious flu endemics and epidemics within hosts or even across different hosts. ...

Khalaj-Hedayati A, Chua CLL, Smooker P, Lee KW. Nanoparticles in influenza subunit vaccine development: Immunogenicity enhancement. Influenza Other Respir Viruses. 2019 Nov 27.  Abstract  
submitted by kickingbird at 7 days ago from Influenza Other Respir Viruses. 2019 Nov 27 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12697)
The threat of novel influenza infections has sparked research efforts to develop subunit vaccines that can induce a more broadly protective immunity by targeting selected regions of the virus. In general, ...

Hanpaibool C, et al. Source of oseltamivir resistance due to single E119D and double E119D/H274Y mutations in pdm09H1N1 influenza neuraminidase. J Comput Aided Mol Des. 2019 Nov 26.  Abstract  
submitted by kickingbird at 7 days ago from J Comput Aided Mol Des. 2019 Nov 26 (via https://www.ncbi.nlm.nih.gov/pubmed/31773463)
Influenza epidemics are responsible for an average of 3-5 millions of severe cases and up to 500,000 deaths around the world. One of flu pandemic types is influenza A(H1N1)pdm09 virus (pdm09H1N1). Oseltamivir ...

Haller O, Kochs G. Mx genes: host determinants controlling influenza virus infection and trans-species transmission. Hum Genet. 2019 Nov 26..  Abstract  
submitted by kickingbird at 7 days ago from Hum Genet. 2019 Nov 26. (via https://www.ncbi.nlm.nih.gov/pubmed/31773252)
The human MxA protein, encoded by the interferon-inducible MX1 gene, is an intracellular influenza A virus (IAV) restriction factor. It can protect transgenic mice from severe IAV-induced disease, indicating ...

Wang Y, Song T, Li K, Jin Y, Yue J, Ren H, Liang L. Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes. Biomed Res Int. 2019 Oct 22;2019:4794910.  Abstract  
submitted by kickingbird at 7 days ago from Biomed Res Int. 2019 Oct 22;2019:4794910 (via https://www.hindawi.com/journals/bmri/2019/4794910/)
Different subtypes of influenza A viruses (IAVs) cause different pathogenic phenotypes after infecting human bodies. Analysis of the interactions between viral proteins and the host proteins may provide ...

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