Pascua PNQ, Jones JC, Marathe BM, Seiler P, Caufie. Baloxavir treatment delays influenza B virus transmission in ferrets and results in limited generation of drug-resistant variants. Antimicrob Agents Chemother. 2021 Aug 23:AAC011372. Abstract
submitted by kickingbird at Aug, 24, 2021 from Antimicrob Agents Chemother. 2021 Aug 23:AAC011372 (via https://journals.asm.org/doi/10.1128/AAC.01137-21)
Clinical efficacy of the influenza antiviral baloxavir marboxil (baloxavir) is compromised by treatment-emergent variants harboring a polymerase acidic protein I38T substitution. However, the fitness of ... Chakma S, Osmani MG, Akwar H, Hasan Z, Nasrin T, K. Risk Areas for Influenza A(H5) Environmental Contamination in Live Bird Markets, Dhaka, Bangladesh. Emerg Infect Dis. 2021 Sep;27(9):2399-2408. Abstract
submitted by kickingbird at Aug, 24, 2021 from Emerg Infect Dis. 2021 Sep;27(9):2399-2408 (via https://wwwnc.cdc.gov/eid/article/27/9/20-4447_article)
We evaluated the presence of influenza A(H5) virus environmental contamination in live bird markets (LBMs) in Dhaka, Bangladesh. By using Bernoulli generalized linear models and multinomial logistic regression ... Blaurock C, Blohm U, Luttermann C, Holzerland J, S. The C-Terminus of Non-Structural Protein 1 (NS1) in H5N8 Clade 2.3.4.4 Avian Influenza Virus Affects Virus Fitness in Human Cells and Virulence in Mice. Emerg Microbes Infect. 2021 Aug 22:1-48.. Abstract
submitted by kickingbird at Aug, 24, 2021 from Emerg Microbes Infect. 2021 Aug 22:1-48. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1)
Avian influenza viruses (AIV) H5N8 clade 2.3.4.4 pose a public health threat but the viral factors relevant for its potential adaptation to mammals are largely unknown. The non-structural protein 1 (NS1) ... Peng HK, Dombkowski KJ, Freed GL, Creary SE, Smith. Influenza immunization coverage of children with sickle cell disease. Vaccine. 2021 Aug 17:S0264-410X(21)01072-0. Abstract
submitted by kickingbird at Aug, 22, 2021 from Vaccine. 2021 Aug 17:S0264-410X(21)01072-0 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Objectives: To assess receipt of annual flu immunization among children living with sickle cell disease (SCD).Methods: Receipt of flu immunization (2014-2019) by SCD status was assessed among all Michigan ... Han T, Lai Y, Jiang Y, Liu X, Li D. Influenza A virus infects pulmonary microvascular endothelial cells leading to microvascular leakage and release of pro-inflammatory cytokines. PeerJ. 2021 Aug 3;9:e11892. Abstract
submitted by kickingbird at Aug, 22, 2021 from PeerJ. 2021 Aug 3;9:e11892 (via https://peerj.com/articles/11892/)
Objective: To investigate the replication of influenza A virus A/Puerto Rico/8/34 (H1N1) in pulmonary microvascular endothelial cells and its effect on endothelial barrier function.Methods: Human pulmonary ... Flores-Torres AS, Rendon A, Salinas-Carmona MC, Sa. Human Eosinophils Reduce Viral Titer, Secrete IL-8, and Increase RIG-I Expression in Response to Influenza A H1N1 pdm09. Viral Immunol. 2021 Aug 19. Abstract
submitted by kickingbird at Aug, 22, 2021 from Viral Immunol. 2021 Aug 19 (via https://www.liebertpub.com/doi/10.1089/vim.2021.0004)
Eosinophils participate in the immune response against many pathogens, including viruses. Since mouse eosinophils are susceptible to influenza A virus infection and possess antiviral activity, we evaluated ... Gao R, Zheng H, Liu K, Ji Z, Cai M, Gu M, Hu J, Li. Genesis, Evolution and Host Species Distribution of influenza A (H10N3) Virus in China. J Infect. 2021 Aug 17:S0163-4453(21)00403-5. Abstract
submitted by kickingbird at Aug, 22, 2021 from J Infect. 2021 Aug 17:S0163-4453(21)00403-5 (via https://www.journalofinfection.com/article/S0163-4453(21)004)
A recent article by Wang in the Journal of Infection ( 1 ) confirmed the first case of human infection with H10N3 avian influenza virus (AIV) in Zhenjiang, Jiangsu Province, China, in April 2021. Transmission ... Chen Y, Graf L, Chen T, Liao Q, Bai T, Petric PP,. Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus. Science. 2021 Aug 20;373(6557):918-922. Abstract
submitted by kickingbird at Aug, 20, 2021 from Science. 2021 Aug 20;373(6557):918-922 (via https://science.sciencemag.org/content/373/6557/918)
Zoonotic avian influenza A virus (IAV) infections are rare. Sustained transmission of these IAVs between humans has not been observed, suggesting a role for host genes. We used whole-genome sequencing ... Cardona C, Wileman B, Malladi S, Ceballos R, Culha. The Risk of Highly Pathogenic Influenza A Virus Transmission to Turkey Hen Flocks Through Artificial Insemination. Avian Dis. 2021 Jun;65(2):303-309. Abstract
submitted by kickingbird at Aug, 20, 2021 from Avian Dis. 2021 Jun;65(2):303-309 (via https://bioone.org/journals/avian-diseases/volume-65/issue-2)
Artificial insemination is a routine practice for turkeys that can introduce pathogens into breeder flocks in a variety of ways. In this manuscript, a risk analysis on the potential transmission of highly ... Zhong ZJ, Hu XT, Cheng LP, Zhang XY, Zhang Q, Zhan. Discovery of novel thiophene derivatives as potent neuraminidase inhibitors. Eur J Med Chem. 2021 Aug 13;225:113762. Abstract
submitted by kickingbird at Aug, 20, 2021 from Eur J Med Chem. 2021 Aug 13;225:113762 (via https://www.sciencedirect.com/science/article/abs/pii/S02235)
Neuraminidase (NA) is an important target for the treatment of influenza. In this study, a new lead NA inhibitor, 4 (ZINC01121127), was discovered by pharmacophore-based virtual screening and molecular ... Burnham AJ, Miller JR, Singh I, Billings EA, Rush. Novel isoforms of influenza virus PA-X and PB1-F2 indicated by automatic annotation. Virus Res. 2021 Aug 12:198545. Abstract
submitted by kickingbird at Aug, 20, 2021 from Virus Res. 2021 Aug 12:198545 (via https://www.sciencedirect.com/science/article/pii/S016817022)
The influenza A virus genome contains 8 gene segments encoding 10 commonly recognized proteins. Additional protein products have been identified including PB1-F2 and PA-X. We report in-silico identification ... Lagare A, Rajatonirina S, Testa J, Mamadou S. The epidemiology of seasonal influenza after the 2009 influenza pandemic in Africa: a systematic review. Afr Health Sci. 2020 Dec;20(4):1514-1536.. Abstract
submitted by kickingbird at Aug, 20, 2021 from Afr Health Sci. 2020 Dec;20(4):1514-1536. (via https://www.ajol.info/index.php/ahs/article/view/202264)
Background: Influenza infection is a serious public health problem that causes an estimated 3 to 5 million cases and 250,000 deaths worldwide every year. The epidemiology of influenza is well-documented ... de Lara AC, Garrido-Mantilla J, Lopez-Moreno G, Ya. Effect of pooling udder skin wipes on the detection of influenza A virus in preweaning pigs. J Vet Diagn Invest. 2021 Aug 17:10406387211039462. Abstract
submitted by kickingbird at Aug, 19, 2021 from J Vet Diagn Invest. 2021 Aug 17:10406387211039462 (via https://journals.sagepub.com/doi/10.1177/10406387211039462)
Influenza A virus (IAV) active surveillance in pigs prior to weaning is commonly conducted by collecting individual samples, mostly nasal swabs. Recently, the use of udder skin wipes collected from lactating ... Mutisari D, Muflihanah M, Wibawa H, Hendrawati F,. Phylogenetic analysis of HPAI H5N1 virus from duck swab specimens in Indonesia. J Adv Vet Anim Res. 2021 Jun 28;8(2):346-354.. Abstract
submitted by kickingbird at Aug, 17, 2021 from J Adv Vet Anim Res. 2021 Jun 28;8(2):346-354. (via https://www.ejmanager.com/mnstemps/39/39-1617077743.pdf?t=16)
Objective: A phylogenetic study was carried out on the avian influenza virus (AIV) isolated from a disease outbreak in Sidenreng Rappang Regency, South Sulawesi, Indonesia, in 2018.Material and methods: ... Wang Z, Chen Y, Chen H, Meng F, Tao S, Ma S, Qiao. A single amino acid at position 158 in hemagglutinin affects the antigenic property of Eurasian Avian-like H1N1 Swine influenza viruses. Transbound Emerg Dis. 2021 Aug 15. Abstract
submitted by kickingbird at Aug, 17, 2021 from Transbound Emerg Dis. 2021 Aug 15 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14288)
Influenza viruses have been posing a great threat to public health and animal industry. The developed vaccines have been widely used to reduce the risk of potential pandemic; however, the ongoing antigenic ... Liu Y, Wang X, Zhou J, Shi S, Shen T, Chen L, Zhan. Development of PDA Nanoparticles for H9N2 Avian Influenza BPP-V/BP-IV Epitope Peptide Vaccines: Immunogenicity and Delivery Efficiency Improvement. Front Immunol. 2021 Jul 27;12:693972. Abstract
submitted by kickingbird at Aug, 16, 2021 from Front Immunol. 2021 Jul 27;12:693972 (via https://www.frontiersin.org/articles/10.3389/fimmu.2021.6939)
The protection of current influenza vaccines is limited due to the viral antigenic shifts and antigenic drifts. The universal influenza vaccine is a new hotspot in vaccine research that aims to overcome ... Faleye TOC, Adams D, Adhikari S, Sandrolini H, Hal. Use of hemagglutinin and neuraminidase amplicon-based high-throughput sequencing with variant analysis to detect co-infection and resolve identical consensus sequences of seasonal influenza in a unive. BMC Infect Dis. 2021 Aug 13;21(1):810. Abstract
submitted by kickingbird at Aug, 16, 2021 from BMC Infect Dis. 2021 Aug 13;21(1):810 (via https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128)
Background: Local transmission of seasonal influenza viruses (IVs) can be difficult to resolve. Here, we study if coupling high-throughput sequencing (HTS) of hemagglutinin (HA) and neuraminidase (NA) ... Meiring S, Tempia S, Dominic EM, de Gouveia L, McA. Excess invasive meningococcal disease associated with seasonal influenza, South Africa, 2003-2018. Clin Infect Dis. 2021 Aug 14:ciab702. Abstract
submitted by kickingbird at Aug, 16, 2021 from Clin Infect Dis. 2021 Aug 14:ciab702 (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
Background: Invasive meningococcal disease (IMD) is a devastating illness with high mortality. Like influenza, endemic IMD is seasonal peaking in winter. Studies suggest that circulation of influenza virus ... Stinson JA, Boopathy AV, Cieslewicz BM, Zhang Y, H. Enhancing influenza vaccine immunogenicity and efficacy through infection mimicry using silk microneedles. Vaccine. 2021 Aug 11:S0264-410X(21)00957-9. Abstract
submitted by kickingbird at Aug, 16, 2021 from Vaccine. 2021 Aug 11:S0264-410X(21)00957-9 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Traditional bolus vaccine administration leads to rapid clearance of vaccine from lymphoid tissue. However, there is increasing evidence suggesting that the kinetics of antigen delivery can impact immune ... Burnham AJ, Miller JR, Singh I, Billings EA, Rush. Novel isoforms of influenza virus PA-X and PB1-F2 indicated by automatic annotation. Virus Res. 2021 Aug 12:198545. Abstract
submitted by kickingbird at Aug, 16, 2021 from Virus Res. 2021 Aug 12:198545 (via https://www.sciencedirect.com/science/article/abs/pii/S01681)
The influenza A virus genome contains 8 gene segments encoding 10 commonly recognized proteins. Additional protein products have been identified including PB1-F2 and PA-X. We report in-silico identification ... 7725 items, 20/Page, Page[91/387][|<<] [|<] [91] [92] [93] [94] [95] [96] [97] [98] [99] [100] [>|] [>>|] |
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