Neuzil KM, Anderson EJ, Frenck RW, Frey SE, Walter. Safety and Immunogenicity of Influenza A/H5N8 Virus Vaccine in Healthy Adults: Durability and Cross-reactivity of Antibody Responses. Clin Infect Dis. 2023 Jan 5:ciac982. Abstract
submitted by kickingbird at Jan, 9, 2023 from Clin Infect Dis. 2023 Jan 5:ciac982 (via https://academic.oup.com/cid/advance-article-abstract/doi/10)
Background: Influenza A/H5N8 viruses infect poultry and wild birds in many countries. In 2021, the first human A/H5N8 cases were reported.Methods: We conducted a phase I, cohort-randomized, double-blind, ...
Zhang J, Nian X, Li X, Huang S, Duan K, Li X, Yang. The Epidemiology of Influenza and the Associated Vaccines Development in China: A Review. Vaccines (Basel). 2022 Nov 6;10(11):1873. Abstract
submitted by kickingbird at Nov, 12, 2022 from Vaccines (Basel). 2022 Nov 6;10(11):1873 (via https://www.mdpi.com/2076-393X/10/11/1873)
Influenza prevention and control has been one of the biggest challenges encountered in the public health domain. The vaccination against influenza plays a pivotal role in the prevention of influenza, particularly ...
Kang T, Haque MM, Lee B, Hong KT, Hong SC, Kim Y,. Orthogonally-tunable and ER-targeting fluorophores detect avian influenza virus early infection. Nat Commun. 2022 Oct 4;13(1):5841. Abstract
submitted by kickingbird at Oct, 7, 2022 from Nat Commun. 2022 Oct 4;13(1):5841
Cell-based assays can monitor virus infection at a single-cell level with high sensitivity and cost-efficiency. For this purpose, it is crucial to develop molecular probes that respond selectively to physiological ...
Hiono T, Kobayashi D. Receptor-Binding Assay for Avian Influenza Viruses. Methods Mol Biol. 2022;2556:141-148. Abstract
submitted by kickingbird at Oct, 1, 2022 from Methods Mol Biol. 2022;2556:141-148 (via https://link.springer.com/protocol/10.1007/978-1-0716-2635-1)
It is well known that influenza viruses utilize host cell glycans for virus attachment factors via their major glycoprotein, hemagglutinin (HA), to initiate their invasion to host cells. Unlike well-known ...
Liu Y, Chen H, Duan W, Zhang X, He X, Nielsen R, M. Predicting Egg Passage Adaptations to Design Better Vaccines for the H3N2 Influenza Virus. Viruses. 2022 Sep 17;14(9):2065. Abstract
submitted by kickingbird at Sep, 23, 2022 from Viruses. 2022 Sep 17;14(9):2065 (via https://www.mdpi.com/1999-4915/14/9/2065)
Seasonal H3N2 influenza evolves rapidly, leading to an extremely poor vaccine efficacy. Substitutions employed during vaccine production using embryonated eggs (i.e., egg passage adaptation) contribute ...
Li C, Culhane MR, Schroeder DC, Cheeran MC, Galina. Vaccination decreases the risk of influenza A virus reassortment but not genetic variation in pigs. Elife. 2022 Sep 2;11:e78618. Abstract
submitted by kickingbird at Sep, 3, 2022 from Elife. 2022 Sep 2;11:e78618 (via https://elifesciences.org/articles/78618)
Although vaccination is broadly used in North American swine breeding herds, managing swine influenza is challenging primarily due to the continuous evolution of influenza A virus (IAV) and the ability ...
Shin Y, Kim J, Seok JH, Park H, Cha HR, Ko SH, Lee. Development of the H3N2 influenza microneedle vaccine for cross-protection against antigenic variants. Sci Rep. 2022 Jul 16;12(1):12189. Abstract
submitted by kickingbird at Jul, 18, 2022 from Sci Rep. 2022 Jul 16;12(1):12189 (via https://www.nature.com/articles/s41598-022-16365-2)
Due to the continuously mutating nature of the H3N2 virus, two aspects were considered when preparing the H3N2 microneedle vaccines: (1) rapid preparation and (2) cross-protection against multiple antigenic ...
Gao J, Li X, Klenow L, Malik T, Wan H, Ye Z, Danie. Antigenic comparison of the neuraminidases from recent influenza A vaccine viruses and 2019-2020 circulating strains. NPJ Vaccines. 2022 Jul 14;7(1):79. Abstract
submitted by kickingbird at Jul, 16, 2022 from NPJ Vaccines. 2022 Jul 14;7(1):79 (via https://www.nature.com/articles/s41541-022-00500-1)
Although viral-based influenza vaccines contain neuraminidase (NA or N) antigens from the recommended seasonal strains, NA is not extensively evaluated like hemagglutinin (H) during the strain selection ...
Chiem K, Nogales A, Martinez-Sobrido L. Generation, Characterization, and Applications of Influenza A Reporter Viruses. Methods Mol Biol. 2022;2524:249-268. Abstract
submitted by kickingbird at Jul, 14, 2022 from Methods Mol Biol. 2022;2524:249-268 (via https://link.springer.com/protocol/10.1007/978-1-0716-2453-1)
Secondary experimental procedures such as immunostaining have been utilized to study wild-type influenza A viruses (IAV) but are inadequate to rapidly determine the virus in infected cells or for the high-throughput ...
Subbiah J, Oh J, Kim KH, Shin CH, Park BR, Bhatnag. A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine. NPJ Vaccines. 2022 Jun 29;7(1):68. Abstract
submitted by kickingbird at Jul, 1, 2022 from NPJ Vaccines. 2022 Jun 29;7(1):68 (via https://www.nature.com/articles/s41541-022-00498-6)
We developed a new chimeric M2e and H3 hemagglutinin (HA) stalk protein vaccine (M2e-H3 stalk) by genetic engineering of modified H3 stalk domain conjugated with conserved M2e epitopes to overcome the ...
Canaday LM, Resnick JD, Liu H, Powell H, McCoy AM,. HA and M2 sequences alter the replication of 2013-16 H1 live attenuated influenza vaccine infection in human nasal epithelial cell cultures. Vaccine. 2022 Jun 16:S0264-410X(22)00733-2. Abstract
submitted by kickingbird at Jun, 23, 2022 from Vaccine. 2022 Jun 16:S0264-410X(22)00733-2 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
From 2013 to 2016, the H1N1 component of live, attenuated influenza vaccine (LAIV) performed very poorly in contrast to the inactivated influenza vaccine. We utilized a primary, differentiated human nasal ...
Zhuang X, Chen L, Yang S, Xia S, Xu Z, Zhang T, Ze. R848 Adjuvant Laden With Self-Assembled Nanoparticle-Based mRNA Vaccine Elicits Protective Immunity Against H5N1 in Mice. Front Immunol. 2022 May 31;13:836274. Abstract
submitted by kickingbird at Jun, 18, 2022 from Front Immunol. 2022 May 31;13:836274 (via https://www.frontiersin.org/articles/10.3389/fimmu.2022.8362)
In order to perfect the design strategy of messenger RNA (mRNA) vaccines against the H5N1 influenza virus, we investigated whether different antigen designs and the use of adjuvants could improve the immune ...
Saengchoowong S, Nimsamer P, Khongnomnan K, Poomip. Enhancing the yield of seasonal influenza viruses through manipulation of microRNAs in Madin-Darby canine kidney cells. Exp Biol Med (Maywood). 2022 Jun 6:153537022210983. Abstract
submitted by kickingbird at Jun, 7, 2022 from Exp Biol Med (Maywood). 2022 Jun 6:153537022210983 (via https://journals.sagepub.com/doi/10.1177/15353702221098340)
Annual influenza vaccine is recommended to reduce the occurrence of seasonal influenza and its complications. Thus far, Madin-Darby canine kidney (MDCK) cell line has been used to manufacture cell-based ...
Yang YH, Tai CH, Cheng D, Wang YF, Wang JR. Investigation of Avian Influenza H5N6 Virus-like Particles as a Broad-Spectrum Vaccine Candidate against H5Nx Viruses. Viruses. 2022 Apr 28;14(5):925. Abstract
submitted by kickingbird at May, 29, 2022 from Viruses. 2022 Apr 28;14(5):925 (via https://www.mdpi.com/1999-4915/14/5/925)
Highly pathogenic avian influenza (HPAI) clade 188.8.131.52 viruses have been reported to be the source of infections in several outbreaks in the past decades. In a previous study, we screened out a broad-spectrum ...
Lin X, Sheng Y, Zhang X, Li Z, Yang Y, Wu J, Su Z,. Oil-in-ionic liquid nanoemulsion-based intranasal delivery system for influenza split-virus vaccine. J Control Release. 2022 Apr 25:S0168-3659(22)00232. Abstract
submitted by kickingbird at Apr, 30, 2022 from J Control Release. 2022 Apr 25:S0168-3659(22)00232 (via https://pubmed.ncbi.nlm.nih.gov/35483639/)
Effective antigen delivery and immune stimulation in nasal mucosa determine the success of mucosal immunity. Here, an oil-in-ionic liquid (o/IL) nanoemulsion formulated with choline and niacin IL ([Cho][Nic]), ...
Gromadzka B, Chraniuk M, Hovhannisyan L, Uranowska. Characterization of Immune Response towards Generation of Universal Anti-HA-Stalk Antibodies after Immunization of Broiler Hens with Triple H5N1/NA-HA-M1 VLPs. Viruses. 2022 Mar 30;14(4):730. Abstract
submitted by kickingbird at Apr, 24, 2022 from Viruses. 2022 Mar 30;14(4):730 (via https://www.mdpi.com/1999-4915/14/4/730)
(1) Background: Avian influenza viruses (AIVs) promptly evade preexisting immunity by constantly altering the immunodominant neutralizing antibody epitopes (antigenic drift) or by procuring new envelope ...
Tian Y, Lee J, van der Maaden K, Bhide Y, de Vries. Intradermal administration of influenza vaccine with trehalose and pullulan-based dissolving microneedle arrays. J Pharm Sci. 2022 Feb 2:S0022-3549(22)00042-9. Abstract
submitted by kickingbird at Feb, 8, 2022 from J Pharm Sci. 2022 Feb 2:S0022-3549(22)00042-9 (via https://jpharmsci.org/article/S0022-3549(22)00042-9/fulltext)
Most influenza vaccines are administered via intramuscular injection which has several disadvantages that might jeopardize the compliance of vaccinees. Intradermal administration of dissolving-microneedle-arrays ...
Zhu D, Lv M, Bai Y, Wu J, He P. Cost-effectiveness analysis of quadrivalent seasonal influenza vaccines in Beijing: A modeling analysis. Vaccine. 2022 Jan 19:S0264-410X(22)00024-X. Abstract
submitted by kickingbird at Jan, 25, 2022 from Vaccine. 2022 Jan 19:S0264-410X(22)00024-X (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Background: Since 2007, Beijing has offered a free trivalent influenza vaccine (TIV) for residents aged ≥ 60 years and school students. The quadrivalent influenza vaccine (QIV) was administered to school ...
Qiao Y, Jin S, Nie J, Chang Y, Wang B, Guan S, Li. Hemagglutinin-based DNA vaccines containing trimeric self-assembling nanoparticles confer protection against influenza. J Leukoc Biol. 2022 Jan 17. Abstract
submitted by kickingbird at Jan, 19, 2022 from J Leukoc Biol. 2022 Jan 17 (via https://jlb.onlinelibrary.wiley.com/doi/10.1002/JLB.6A1021-5)
Influenza viruses continue to threaten public health, and currently available vaccines provide insufficient immunity against seasonal and pandemic influenza. The use of recombinant trimeric hemagglutinin ...
Sun W, Wang Z, Sun Y, Li D, Zhu M, Zhao M, Wang Y,. Safety, Immunogenicity, and Protective Efficacy of an H5N1 Chimeric Cold-Adapted Attenuated Virus Vaccine in a Mouse Model. Viruses. 2021 Dec 3;13(12):2420. Abstract
submitted by kickingbird at Dec, 29, 2021 from Viruses. 2021 Dec 3;13(12):2420 (via https://www.mdpi.com/1999-4915/13/12/2420)
H5N1 influenza virus is a threat to public health worldwide. The virus can cause severe morbidity and mortality in humans. We constructed an H5N1 influenza candidate virus vaccine from the A/chicken/Guizhou/1153/2016 ...
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