Shin Y, Kim J, Seok JH, Park H, Cha HR, Ko SH, Lee. Development of the H3N2 influenza microneedle vaccine for cross-protection against antigenic variants. Sci Rep. 2022 Jul 16;12(1):12189. Abstract
submitted by kickingbird at Jul, 18, 2022 from Sci Rep. 2022 Jul 16;12(1):12189 (via https://www.nature.com/articles/s41598-022-16365-2)
Due to the continuously mutating nature of the H3N2 virus, two aspects were considered when preparing the H3N2 microneedle vaccines: (1) rapid preparation and (2) cross-protection against multiple antigenic ...
Gao J, Li X, Klenow L, Malik T, Wan H, Ye Z, Danie. Antigenic comparison of the neuraminidases from recent influenza A vaccine viruses and 2019-2020 circulating strains. NPJ Vaccines. 2022 Jul 14;7(1):79. Abstract
submitted by kickingbird at Jul, 16, 2022 from NPJ Vaccines. 2022 Jul 14;7(1):79 (via https://www.nature.com/articles/s41541-022-00500-1)
Although viral-based influenza vaccines contain neuraminidase (NA or N) antigens from the recommended seasonal strains, NA is not extensively evaluated like hemagglutinin (H) during the strain selection ...
Chiem K, Nogales A, Martinez-Sobrido L. Generation, Characterization, and Applications of Influenza A Reporter Viruses. Methods Mol Biol. 2022;2524:249-268. Abstract
submitted by kickingbird at Jul, 14, 2022 from Methods Mol Biol. 2022;2524:249-268 (via https://link.springer.com/protocol/10.1007/978-1-0716-2453-1)
Secondary experimental procedures such as immunostaining have been utilized to study wild-type influenza A viruses (IAV) but are inadequate to rapidly determine the virus in infected cells or for the high-throughput ...
Subbiah J, Oh J, Kim KH, Shin CH, Park BR, Bhatnag. A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine. NPJ Vaccines. 2022 Jun 29;7(1):68. Abstract
submitted by kickingbird at Jul, 1, 2022 from NPJ Vaccines. 2022 Jun 29;7(1):68 (via https://www.nature.com/articles/s41541-022-00498-6)
We developed a new chimeric M2e and H3 hemagglutinin (HA) stalk protein vaccine (M2e-H3 stalk) by genetic engineering of modified H3 stalk domain conjugated with conserved M2e epitopes to overcome the ...
Canaday LM, Resnick JD, Liu H, Powell H, McCoy AM,. HA and M2 sequences alter the replication of 2013-16 H1 live attenuated influenza vaccine infection in human nasal epithelial cell cultures. Vaccine. 2022 Jun 16:S0264-410X(22)00733-2. Abstract
submitted by kickingbird at Jun, 23, 2022 from Vaccine. 2022 Jun 16:S0264-410X(22)00733-2 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
From 2013 to 2016, the H1N1 component of live, attenuated influenza vaccine (LAIV) performed very poorly in contrast to the inactivated influenza vaccine. We utilized a primary, differentiated human nasal ...
Zhuang X, Chen L, Yang S, Xia S, Xu Z, Zhang T, Ze. R848 Adjuvant Laden With Self-Assembled Nanoparticle-Based mRNA Vaccine Elicits Protective Immunity Against H5N1 in Mice. Front Immunol. 2022 May 31;13:836274. Abstract
submitted by kickingbird at Jun, 18, 2022 from Front Immunol. 2022 May 31;13:836274 (via https://www.frontiersin.org/articles/10.3389/fimmu.2022.8362)
In order to perfect the design strategy of messenger RNA (mRNA) vaccines against the H5N1 influenza virus, we investigated whether different antigen designs and the use of adjuvants could improve the immune ...
Saengchoowong S, Nimsamer P, Khongnomnan K, Poomip. Enhancing the yield of seasonal influenza viruses through manipulation of microRNAs in Madin-Darby canine kidney cells. Exp Biol Med (Maywood). 2022 Jun 6:153537022210983. Abstract
submitted by kickingbird at Jun, 7, 2022 from Exp Biol Med (Maywood). 2022 Jun 6:153537022210983 (via https://journals.sagepub.com/doi/10.1177/15353702221098340)
Annual influenza vaccine is recommended to reduce the occurrence of seasonal influenza and its complications. Thus far, Madin-Darby canine kidney (MDCK) cell line has been used to manufacture cell-based ...
Yang YH, Tai CH, Cheng D, Wang YF, Wang JR. Investigation of Avian Influenza H5N6 Virus-like Particles as a Broad-Spectrum Vaccine Candidate against H5Nx Viruses. Viruses. 2022 Apr 28;14(5):925. Abstract
submitted by kickingbird at May, 29, 2022 from Viruses. 2022 Apr 28;14(5):925 (via https://www.mdpi.com/1999-4915/14/5/925)
Highly pathogenic avian influenza (HPAI) clade 220.127.116.11 viruses have been reported to be the source of infections in several outbreaks in the past decades. In a previous study, we screened out a broad-spectrum ...
Lin X, Sheng Y, Zhang X, Li Z, Yang Y, Wu J, Su Z,. Oil-in-ionic liquid nanoemulsion-based intranasal delivery system for influenza split-virus vaccine. J Control Release. 2022 Apr 25:S0168-3659(22)00232. Abstract
submitted by kickingbird at Apr, 30, 2022 from J Control Release. 2022 Apr 25:S0168-3659(22)00232 (via https://pubmed.ncbi.nlm.nih.gov/35483639/)
Effective antigen delivery and immune stimulation in nasal mucosa determine the success of mucosal immunity. Here, an oil-in-ionic liquid (o/IL) nanoemulsion formulated with choline and niacin IL ([Cho][Nic]), ...
Gromadzka B, Chraniuk M, Hovhannisyan L, Uranowska. Characterization of Immune Response towards Generation of Universal Anti-HA-Stalk Antibodies after Immunization of Broiler Hens with Triple H5N1/NA-HA-M1 VLPs. Viruses. 2022 Mar 30;14(4):730. Abstract
submitted by kickingbird at Apr, 24, 2022 from Viruses. 2022 Mar 30;14(4):730 (via https://www.mdpi.com/1999-4915/14/4/730)
(1) Background: Avian influenza viruses (AIVs) promptly evade preexisting immunity by constantly altering the immunodominant neutralizing antibody epitopes (antigenic drift) or by procuring new envelope ...
Tian Y, Lee J, van der Maaden K, Bhide Y, de Vries. Intradermal administration of influenza vaccine with trehalose and pullulan-based dissolving microneedle arrays. J Pharm Sci. 2022 Feb 2:S0022-3549(22)00042-9. Abstract
submitted by kickingbird at Feb, 8, 2022 from J Pharm Sci. 2022 Feb 2:S0022-3549(22)00042-9 (via https://jpharmsci.org/article/S0022-3549(22)00042-9/fulltext)
Most influenza vaccines are administered via intramuscular injection which has several disadvantages that might jeopardize the compliance of vaccinees. Intradermal administration of dissolving-microneedle-arrays ...
Zhu D, Lv M, Bai Y, Wu J, He P. Cost-effectiveness analysis of quadrivalent seasonal influenza vaccines in Beijing: A modeling analysis. Vaccine. 2022 Jan 19:S0264-410X(22)00024-X. Abstract
submitted by kickingbird at Jan, 25, 2022 from Vaccine. 2022 Jan 19:S0264-410X(22)00024-X (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Background: Since 2007, Beijing has offered a free trivalent influenza vaccine (TIV) for residents aged ≥ 60 years and school students. The quadrivalent influenza vaccine (QIV) was administered to school ...
Qiao Y, Jin S, Nie J, Chang Y, Wang B, Guan S, Li. Hemagglutinin-based DNA vaccines containing trimeric self-assembling nanoparticles confer protection against influenza. J Leukoc Biol. 2022 Jan 17. Abstract
submitted by kickingbird at Jan, 19, 2022 from J Leukoc Biol. 2022 Jan 17 (via https://jlb.onlinelibrary.wiley.com/doi/10.1002/JLB.6A1021-5)
Influenza viruses continue to threaten public health, and currently available vaccines provide insufficient immunity against seasonal and pandemic influenza. The use of recombinant trimeric hemagglutinin ...
Sun W, Wang Z, Sun Y, Li D, Zhu M, Zhao M, Wang Y,. Safety, Immunogenicity, and Protective Efficacy of an H5N1 Chimeric Cold-Adapted Attenuated Virus Vaccine in a Mouse Model. Viruses. 2021 Dec 3;13(12):2420. Abstract
submitted by kickingbird at Dec, 29, 2021 from Viruses. 2021 Dec 3;13(12):2420 (via https://www.mdpi.com/1999-4915/13/12/2420)
H5N1 influenza virus is a threat to public health worldwide. The virus can cause severe morbidity and mortality in humans. We constructed an H5N1 influenza candidate virus vaccine from the A/chicken/Guizhou/1153/2016 ...
Yoo DS, Song YH, Choi DW, Lim JS, Lee K, Kang T. Machine Learning-driven dynamic risk prediction for highly pathogenic avian influenza at poultry farms, Republic of Korea: daily risk estimation for individual premises. Transbound Emerg Dis. 2021 Dec 13. Abstract
submitted by kickingbird at Dec, 15, 2021 from Transbound Emerg Dis. 2021 Dec 13 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14419)
Highly pathogenic Avian influenza (HPAI) is a fatal zoonotic disease that damages the poultry industry and endangers human lives via exposure to the pathogen. A risk assessment model that precisely predicts ...
Yin Y, Wang J, Xu X, Zhou B, Chen S, Qin T, Peng D. Riboflavin as a Mucosal Adjuvant for Nasal Influenza Vaccine. Vaccines (Basel). 2021 Nov 9;9(11):1296. Abstract
submitted by kickingbird at Nov, 30, 2021 from Vaccines (Basel). 2021 Nov 9;9(11):1296 (via https://www.mdpi.com/2076-393X/9/11/1296)
Intranasal immunization with whole inactivated virus (WIV) is an important strategy used for influenza prevention and control. However, a powerful mucosal adjuvant is required to improve nasal vaccine ...
Ye Q, Phan T, Hu WS, Liu X, Fan L, Tan WS, Zhao L. Transcriptomic Characterization Reveals Attributes of High Influenza Virus Productivity in MDCK Cells. Viruses. 2021 Nov 1;13(11):2200. Abstract
submitted by kickingbird at Nov, 30, 2021 from Viruses. 2021 Nov 1;13(11):2200 (via https://www.mdpi.com/1999-4915/13/11/2200)
The Madin-Darby Canine Kidney (MDCK) cell line is among the most commonly used cell lines for the production of influenza virus vaccines. As cell culture-based manufacturing is poised to replace egg-based ...
Xiang H, Wen X, Wen Y, Zhang H, Cao S, Huang X, Wu. Development and application of a visual microarray for synchronously detecting H5N1, H7N9 and H9N2 avian influenza virus RNA. J Virol Methods. 2021 Nov 19:114371. Abstract
submitted by kickingbird at Nov, 24, 2021 from J Virol Methods. 2021 Nov 19:114371 (via https://www.sciencedirect.com/science/article/abs/pii/S01660)
The aim of this study was to develop a microarray assay for the simultaneous detection of the H5, H7, H9, N1, N9 and N2 genes of the avian influenza virus (AIV) using a Nanogold-streptavidin and silver-stain-enhanced ...
Kim SH, Park YC, Song JM. Evaluation of the antigenic stability of influenza virus like particles after exposure to acidic or basic pH. Clin Exp Vaccine Res. 2021 Sep;10(3):252-258. Abstract
submitted by kickingbird at Oct, 28, 2021 from Clin Exp Vaccine Res. 2021 Sep;10(3):252-258 (via https://ecevr.org/DOIx.php?id=10.7774/cevr.2021.10.3.252)
Purpose: Virus-like particles (VLPs) are being developed as a promising vaccine platform and therapeutic delivery. Various strategies for effectively constructing VLPs have been studied, but relatively ...
Shinde V, Cho I, Plested JS, Agrawal S, Fiske J, C. Comparison of the safety and immunogenicity of a novel Matrix-M-adjuvanted nanoparticle influenza vaccine with a quadrivalent seasonal influenza vaccine in older adults: a phase 3 randomised controlle. ancet Infect Dis. 2021 Sep 23:S1473-3099(21)00192-. Abstract
submitted by kickingbird at Sep, 28, 2021 from ancet Infect Dis. 2021 Sep 23:S1473-3099(21)00192- (via https://www.thelancet.com/journals/laninf/article/PIIS1473-3)
Background: Improved seasonal influenza vaccines for older adults that can induce broadly cross-reactive antibodies and enhanced T-cell responses, particularly against A H3N2 viruses, while avoiding egg-adaptive ...
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