Chen L, Li G, Tian Y, Zeng T, Xu W, Gu T, Lu L. RNA Sequencing Reveals circRNA Expression Profiles in Chicken DF1 Cells Infected with H5N1 Influenza Virus. Animals (Basel). 2022 Jan 10;12(2):158. Abstract
submitted by kickingbird at 2 days ago from Animals (Basel). 2022 Jan 10;12(2):158 (via https://www.mdpi.com/2076-2615/12/2/158/htm)
H5N1, a highly pathogenic avian influenza virus that is prevalent in Asia, seriously harms the poultry industry and global public health. However, its pathogenesis is still not well understood. Circular ...
Caliendo V, Leijten L, van de Bildt MWG, Fouchier. Pathology and virology of natural highly pathogenic avian influenza H5N8 infection in wild Common buzzards (Buteo buteo). Sci Rep. 2022 Jan 18;12(1):920. Abstract
submitted by kickingbird at 3 days ago from Sci Rep. 2022 Jan 18;12(1):920 (via https://www.nature.com/articles/s41598-022-04896-7)
Highly pathogenic avian influenza (HPAI) in wild birds is a major emerging disease, and a cause of increased mortality during outbreaks. The Common buzzard (Buteo buteo) has a considerable chance of acquiring ...
Miyamoto S, Muramoto Y, Shindo K, Fujita-Fujiharu. Contribution of RNA-RNA interactions mediated by the genome packaging signals for the selective genome packaging of influenza A virus. J Virol. 2022 Jan 19:JVI0164121. Abstract
submitted by kickingbird at 3 days ago from J Virol. 2022 Jan 19:JVI0164121 (via https://journals.asm.org/doi/10.1128/JVI.01641-21)
The influenza A virus genome is composed of eight single-stranded negative-sense RNA segments (vRNAs). The eight vRNAs are selectively packaged into each progeny virion. This process likely involves specific ...
Banerjee S, De A, Kedia N, Bhakta K, Wang L, Bhatt. The species-specific 282 residue in the PB2 subunit of the polymerase regulates RNA synthesis and replication of influenza A viruses infecting bat and non-bat hosts. J Virol. 2022 Jan 19:jvi0219021. Abstract
submitted by kickingbird at 3 days ago from J Virol. 2022 Jan 19:jvi0219021 (via https://journals.asm.org/doi/10.1128/jvi.02190-21)
Bat influenza viruses are genetically distant from classical influenza A viruses (IAV) and show distinct functional differences in their surface antigens. Nevertheless, any comparative analysis between ...
Spruit CM, Zhu X, Tomris I, Carrasco MR, Han AX, B. N-glycolylneuraminic acid binding of avian and equine H7 influenza A viruses. J Virol. 2022 Jan 19:jvi0212021. Abstract
submitted by kickingbird at 3 days ago from J Virol. 2022 Jan 19:jvi0212021 (via https://journals.asm.org/doi/10.1128/jvi.02120-21)
Influenza A viruses (IAV) initiate infection by binding to glycans with terminal sialic acids on the cell surface. Hosts of IAV variably express two major forms of sialic acid, N-acetylneuraminic acid ...
Yu M, Sun L, Zhang Z, Zhang Y, Zhang H, Na L, Wang. KPNA6 is a Cofactor of ANP32A/B in Supporting Influenza Virus Polymerase Activity. Microbiol Spectr. 2022 Jan 19:e0207321. Abstract
submitted by kickingbird at 3 days ago from Microbiol Spectr. 2022 Jan 19:e0207321 (via https://journals.asm.org/doi/10.1128/spectrum.02073-21)
Influenza A virus (IAV) RNA-dependent RNA polymerase (vPol) is a heterotrimer composed of PB2, PB1, and PA, which, together with vRNA and nucleoprotein (NP), forms viral ribonucleoprotein (vRNP) complex ...
Jiang L, Samant N, Liu P, Somasundaran M, Jensen J. Identification of a permissive secondary mutation that restores the enzymatic activity of oseltamivir resistance mutation H275Y. J Virol. 2022 Jan 19:jvi0198221. Abstract
submitted by kickingbird at 3 days ago from J Virol. 2022 Jan 19:jvi0198221 (via https://journals.asm.org/doi/10.1128/jvi.01982-21)
Many oseltamivir resistance mutations exhibit fitness defects in the absence of drug pressure that hinders their propagation in hosts. Secondary permissive mutations can rescue fitness defects and facilitate ...
Encinas P, Del Real G, Dutta J, Khan Z, van Bakel. Evolution of influenza A virus in intensive and free-range swine farms in Spain. Virus Evol. 2021 Nov 30;7(2):veab099. Abstract
submitted by kickingbird at 4 days ago from Virus Evol. 2021 Nov 30;7(2):veab099 (via https://academic.oup.com/ve/article/7/2/veab099/6446465)
Swine harbor genetically diverse influenza A viruses (IAVs) with the capacity to host-switch to humans, causing global pandemics. Spain is the largest swine producer in Europe and has a mixed production ...
Qiao Y, Jin S, Nie J, Chang Y, Wang B, Guan S, Li. Hemagglutinin-based DNA vaccines containing trimeric self-assembling nanoparticles confer protection against influenza. J Leukoc Biol. 2022 Jan 17. Abstract
submitted by kickingbird at 4 days ago from J Leukoc Biol. 2022 Jan 17 (via https://jlb.onlinelibrary.wiley.com/doi/10.1002/JLB.6A1021-5)
Influenza viruses continue to threaten public health, and currently available vaccines provide insufficient immunity against seasonal and pandemic influenza. The use of recombinant trimeric hemagglutinin ...
Goettler D, Niekler P, Liese JG, Streng A. Epidemiology and direct healthcare costs of Influenza-associated hospitalizations - nationwide inpatient data (Germany 2010-2019). BMC Public Health. 2022 Jan 15;22(1):108. Abstract
submitted by kickingbird at 5 days ago from BMC Public Health. 2022 Jan 15;22(1):108 (via https://bmcpublichealth.biomedcentral.com/articles/10.1186/s)
Introduction: Detailed and up-to-date data on the epidemiology and healthcare costs of Influenza are fundamental for public health decision-making. We analyzed inpatient data on Influenza-associated hospitalizations ...
Gao X, Wang N, Chen Y, Gu X, Huang Y, Liu Y, Jiang. Sequence characteristics and phylogenetic analysis of H9N2 subtype avian influenza A viruses detected from poultry and the environment in China, 2018. PeerJ. 2021 Dec 20;9:e12512. Abstract
submitted by kickingbird at 5 days ago from PeerJ. 2021 Dec 20;9:e12512 (via https://peerj.com/articles/12512/)
H9N2 subtype avian influenza A virus (AIV) is a causative agent that poses serious threats to both the poultry industry and global public health. In this study, we performed active surveillance to identify ...
Liu L, Li Z, Zhou J, Liu J, Li X, Huang W, Xiao N,. Homologous PB1 gene promotes the replication efficiency of avian influenza H7N4 candidate vaccine virus. Influenza Other Respir Viruses. 2022 Jan 17. Abstract
submitted by kickingbird at 5 days ago from Influenza Other Respir Viruses. 2022 Jan 17 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.12954)
Background: The first and only case of human infection with the avian influenza A (H7N4) virus in China emerged in 2018. The H7N4 virus was distinct from previous H7N9 viruses and raised public concerns. ...
Tang H, Kang J, Shen C, Wang Y, Robertson ID, Cai. Benefit-cost analysis of a H7N9 vaccination program in poultry in Guangxi, China. Prev Vet Med. 2022 Jan 8;200:105580. Abstract
submitted by kickingbird at 6 days ago from Prev Vet Med. 2022 Jan 8;200:105580 (via https://www.sciencedirect.com/science/article/abs/pii/S01675)
China launched a H7N9 vaccination program in poultry, starting from the Guangxi and Guangdong provinces in July 2017, followed by other provinces in September 2017, as a response to a steep increase of ...
Peterson JM, O´Leary CA, Moss WN. In silico analysis of local RNA secondary structure in influenza virus A, B and C finds evidence of widespread ordered stability but little evidence of significant covariation. Sci Rep. 2022 Jan 10;12(1):310. Abstract
submitted by kickingbird at 10 days ago from Sci Rep. 2022 Jan 10;12(1):310 (via https://www.nature.com/articles/s41598-021-03767-x)
Influenza virus is a persistent threat to human health; indeed, the deadliest modern pandemic was in 1918 when an H1N1 virus killed an estimated 50 million people globally. The intent of this work is to ...
Omer I, Rosenberg A, Sefty H, Pando R, Mandelboim. Lineage-matched versus mismatched influenza B vaccine effectiveness following seasons of marginal influenza B circulation. Vaccine. 2022 Jan 8:S0264-410X(21)01664-9. Abstract
submitted by kickingbird at 10 days ago from Vaccine. 2022 Jan 8:S0264-410X(21)01664-9 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Background: Several countries have recently transitioned from the trivalent inactivated influenza vaccine (TIV) to the quadrivalent inactivated influenza vaccine (QIV) in order to outweigh influenza B ...
Liu T, Wang P, Meng F, Ding G, Wu J, Song S, Sun L. Incidence, circulation, and spatiotemporal analysis of seasonal influenza in Shandong, China, 2008-2019: A retrospective study. Influenza Other Respir Viruses. 2022 Jan 11. Abstract
submitted by kickingbird at 10 days ago from Influenza Other Respir Viruses. 2022 Jan 11 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.12959)
Background: Understanding the influenza-like illness (ILI) incidence, circulation pattern of virus strains and spatiotemporal pattern of influenza transmission are important for designing control interventions. ...
Bhat S, James J, Sadeyen JR, Mahmood S, Everest HJ. Co-infection of chickens with H9N2 and H7N9 avian influenza viruses leads to emergence of reassortant H9N9 virus with increased fitness for poultry and a zoonotic potential. J Virol. 2022 Jan 12:jvi0185621. Abstract
submitted by kickingbird at 10 days ago from J Virol. 2022 Jan 12:jvi0185621 (via https://journals.asm.org/doi/10.1128/jvi.01856-21)
An H7N9 low pathogenicity avian influenza virus (LPAIV) emerged in 2013 through genetic reassortment between H9N2 and other LPAIVs circulating in birds in China. This virus causes inapparent clinical disease ...
Veler H, Fan H, Keown J, Sharps J, Fournier M, Gri. The C-terminal domains of the PB2 subunit of the influenza A virus RNA polymerase directly interact with cellular GTPase Rab11a. J Virol. 2022 Jan 12:jvi0197921. Abstract
submitted by kickingbird at 10 days ago from J Virol. 2022 Jan 12:jvi0197921 (via https://journals.asm.org/doi/10.1128/jvi.01979-21)
Influenza A virus (IAV) contains a segmented RNA genome that is transcribed and replicated by the viral RNA polymerase in the cell nucleus. Replicated RNA segments are assembled with viral polymerase and ...
Rashid MU, Gao A, Coombs KM. Influenza A virus uses PSMA2 for downregulation of NRF2-mediated oxidative stress response. J Virol. 2022 Jan 12:jvi0199021. Abstract
submitted by kickingbird at 10 days ago from J Virol. 2022 Jan 12:jvi0199021 (via https://journals.asm.org/doi/10.1128/jvi.01990-21)
Influenza A virus (IAV), an obligatory intracellular parasite, uses host cellular molecules to complete its replication cycle and suppress immune responses. Proteasome subunit alpha type-2 (PSMA2) is a ...
Yan W, Cui H, Engelsma M, Beerens N, van Oers MM,. Molecular and Antigenic Characterization of Avian H9N2 Viruses in Southern China. Microbiol Spectr. 2022 Jan 12:e0082221. Abstract
submitted by kickingbird at 10 days ago from Microbiol Spectr. 2022 Jan 12:e0082221 (via https://journals.asm.org/doi/10.1128/spectrum.00822-21)
The H9N2 subtype avian influenza virus (AIV) has become endemic in poultry globally; however due to its low pathogenicity, it is not under primary surveillance and control in many countries. Recent reports ...
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