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2022-8-14 11:08:30


Patrono LV, Vrancken B, Budt M, Düx A, Lequime S,. Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic. Nat Commun. 2022 May 10;13(1):2314
submited by kickingbird at May, 11, 2022 14:0 PM from Nat Commun. 2022 May 10;13(1):2314

The 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here, we analyze both the first 1918 IAV genomes from Europe and the first from samples prior to the autumn peak. 1918 IAV genomic diversity is consistent with a combination of local transmission and long-distance dispersal events. Comparison of genomes before and during the pandemic peak shows variation at two sites in the nucleoprotein gene associated with resistance to host antiviral response, pointing at a possible adaptation of 1918 IAV to humans. Finally, local molecular clock modeling suggests a pure pandemic descent of seasonal H1N1 IAV as an alternative to the hypothesis of origination through an intrasubtype reassortment.

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