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2020-8-9 8:35:09
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Yu L, Pan J, Cao G, et al. AIV polyantigen epitope expressed by recombinant baculovirus induces a systemic immune response in chicken and mouse models. Virol J. 2020;17(1):121.  Abstract  
submitted by kickingbird at 23 hours ago from Virol J. 2020;17(1):121 (via https://pubmed.ncbi.nlm.nih.gov/32758272/)
Background: The protective efficacy of avian influenza virus (AIV) vaccines is unsatisfactory due to the presence of various serotypes generated by genetic reassortment. Thus, immunization with a polyantigen ...

Guo F, Yang J, Pan J, et al. Origin and Evolution of H1N1/pdm2009: A Codon Usage Perspective. Front Microbiol. 2020;11:1615.  Abstract  
submitted by kickingbird at 24 hours ago from Front Microbiol. 2020;11:1615 (via https://pubmed.ncbi.nlm.nih.gov/32760376/)
The H1N1/pdm2009 virus is a new triple-reassortant virus. While Eurasian avian-like and triple-reassortant swine influenza viruses are the direct ancestors of H1N1/pdm2009, the classic swine influenza ...

Wang S, Zheng Y, Jin X, et al. Efficacy and safety of a live attenuated influenza vaccine in Chinese healthy children aged 3-17 years in one study center of a randomized, double-blind, placebo-controlled phase 3 clinical trial, 201. Vaccine. 2020;S0264-410X(20)30932-4.  Abstract  
submitted by kickingbird at 4 days ago from Vaccine. 2020;S0264-410X(20)30932-4 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Background: No data on the safety and efficacy of a live attenuated influenza vaccine in China have ever been reported. Methods: At a site of a phase 3 randomized, double-blind, placebo-controlled clinical ...

Zhou L, Feng Z, Liu J, et al. A single N342D substitution in influenza B Virus NA protein determines viral pathogenicity in mice. Emerg Microbes Infect. 2020;1-35.  Abstract  
submitted by kickingbird at 4 days ago from Emerg Microbes Infect. 2020;1-35 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1)
Influenza B virus (IBV) is one of the most important human respiratory viruses: it causes approximately one-third of the global influenza-related disease burden each year. However, compared with the several ...

Kim SH, Choi JW, Kim AR, Lee SC, Yoon MY. Development of ssDNA Aptamers for Diagnosis and Inhibition of the Highly Pathogenic Avian Influenza Virus Subtype H5N1. Biomolecules. 2020;10(8):E1116.  Abstract  
submitted by kickingbird at 7 days ago from Biomolecules. 2020;10(8):E1116 (via https://pubmed.ncbi.nlm.nih.gov/32731467/)
Avian influenza (AI) has severely affected the poultry industry worldwide and has caused the deaths of millions of birds. Highly pathogenic avian influenza virus is characterized by high mortality and ...

Zhang M, Huang Y, Godson DL, Fernando C, Alexander. Assessment of Metagenomic Sequencing and qPCR for Detection of Influenza D Virus in Bovine Respiratory Tract Samples. Viruses. 2020;12(8):E814.  Abstract  
submitted by kickingbird at 7 days ago from Viruses. 2020;12(8):E814 (via https://pubmed.ncbi.nlm.nih.gov/32731471/)
High throughput sequencing is currently revolutionizing the genomics field and providing new approaches to the detection and characterization of microorganisms. The objective of this study was to assess ...

Dharmayanti NLPI, Hewajuli DA, Ratnawati A, Hartaw. Genetic diversity of the H5N1 viruses in live bird markets, Indonesia. J Vet Sci. 2020;21(4):e56.  Abstract  
submitted by kickingbird at 7 days ago from J Vet Sci. 2020;21(4):e56 (via https://pubmed.ncbi.nlm.nih.gov/32735094/)
Background: The live bird market (LBM) plays an important role in the dynamic evolution of the avian influenza H5N1 virus. Objectives: The main objective of this study was to monitor the genetic diversity ...

Yang F, Xu L, Liu F, Yao H, Wu N, Wu H. Development and evaluation of a TaqMan MGB RT-PCR assay for detection of H5 and N8 subtype influenza virus. BMC Infect Dis. 2020;20(1):550.  Abstract  
submitted by kickingbird at 9 days ago from BMC Infect Dis. 2020;20(1):550 (via https://pubmed.ncbi.nlm.nih.gov/32727378/)
Background: Highly pathogenic influenza A (H5N8) viruses have caused several worldwide outbreaks in birds and are of potential risk to humans. Thus, a specific, rapid and sensitive method for detection ...

Xu Z, Zhou J, Huang Y, et al. Efficacy of convalescent plasma for the treatment of severe influenza. Crit Care. 2020;24(1):469.  Abstract  
submitted by kickingbird at 9 days ago from Crit Care. 2020;24(1):469 (via https://pubmed.ncbi.nlm.nih.gov/32727526/)
Background: Convalescent plasma administration may be of clinical benefit in patients with severe influenza, but reports on the efficacy of this therapy vary. Methods: We conducted a systematic review ...

Hernandez-Mejia G, Hernandez-Vargas EA. Uncovering antibody cross-reaction dynamics in influenza A infections. Bioinformatics. 2020;btaa691.  Abstract  
submitted by kickingbird at 9 days ago from Bioinformatics. 2020;btaa691 (via https://pubmed.ncbi.nlm.nih.gov/32730562/)
Motivation: Influenza viruses are a cause of large outbreaks and pandemics with high death tolls. A key obstacle is that flu vaccines have inconsistent performance, in the best cases up to 60% effectiveness, ...

Pulit-Penaloza JA, Brock N, Pappas C, et al. Characterization of highly pathogenic avian influenza H5Nx viruses in the ferret model. Sci Rep. 2020;10(1):12700.  Abstract  
submitted by kickingbird at 9 days ago from Sci Rep. 2020;10(1):12700 (via https://pubmed.ncbi.nlm.nih.gov/32728042/)
Highly pathogenic avian influenza (HPAI) H5 viruses, of the A/goose/Guangdong/1/1996 lineage, have exhibited substantial geographic spread worldwide since the first detection of H5N1 virus in 1996. Accumulation ...

Li C, Wang T, Zhang Y, Wei F. Evasion mechanisms of the type I interferons responses by influenza A virus. Crit Rev Microbiol. 2020;1-13.  Abstract  
submitted by kickingbird at 12 days ago from Crit Rev Microbiol. 2020;1-13 (via https://www.tandfonline.com/doi/full/10.1080/1040841X.2020.1)
The type I interferons (IFNs) represent the first line of host defense against influenza virus infection, and the precisely control of the type I IFNs responses is a central event of the immune defense ...

Wei J, Li Z, Yang Y, et al. A biomimetic VLP influenza vaccine with interior NP/exterior M2e antigens constructed through a temperature shift-based encapsulation strategy. Vaccine. 2020;S0264-410X(20)30915-4.  Abstract  
submitted by kickingbird at 12 days ago from Vaccine. 2020;S0264-410X(20)30915-4 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Here we present a biomimetic strategy towards an influenza vaccine design based on hepatitis B virus core virus-like particles (HBc VLP). To this end, a temperature-shift based encapsulation process based ...

Shah S, McManus D, Bejou N, et al. Clinical outcomes of baloxavir versus oseltamivir in patients hospitalized with influenza A. J Antimicrob Chemother. 2020;dkaa252.  Abstract  
submitted by kickingbird at 12 days ago from J Antimicrob Chemother. 2020;dkaa252 (via https://pubmed.ncbi.nlm.nih.gov/32712669/)
Objectives: To date, clinical trials evaluating baloxavir have excluded patients hospitalized with influenza infection and therefore this study sought to evaluate the efficacy of baloxavir in inpatients ...

Ayim-Akonor M, Mertens E, May J, Harder T. Exposure of domestic swine to influenza A viruses in Ghana suggests unidirectional, reverse zoonotic transmission at the human-animal interface. Zoonoses Public Health. 2020;10.1111/zph.12751.  Abstract  
submitted by kickingbird at 13 days ago from Zoonoses Public Health. 2020;10.1111/zph.12751 (via https://pubmed.ncbi.nlm.nih.gov/32710707/)
Influenza A viruses (IAVs) have both zoonotic and anthroponotic potential and are of public and veterinary importance. Swine are intermediate hosts and 'mixing vessels' for generating reassortants, progenies ...

van der Woude R, Turner HL, Tomris I, Bouwman KM,. Drivers of recombinant soluble influenza A virus hemagglutinin and neuraminidase expression in mammalian cells. Protein Sci. 2020;10.1002/pro.3918..  Abstract  
submitted by kickingbird at 13 days ago from Protein Sci. 2020;10.1002/pro.3918. (via https://pubmed.ncbi.nlm.nih.gov/32710576/)
Recombinant soluble trimeric influenza A virus hemagglutinins (HA) and tetrameric neuraminidases (NA) have proven to be excellent tools to decipher biological properties. Receptor binding and sialic acid ...

Hobbelen PHF, Elbers ARW, Werkman M, et al. Estimating the introduction time of highly pathogenic avian influenza into poultry flocks. Sci Rep . 2020 Jul 24;10(1):12388.  Abstract  
submitted by kickingbird at 13 days ago from Sci Rep . 2020 Jul 24;10(1):12388 (via https://pubmed.ncbi.nlm.nih.gov/32709965/)
The estimation of farm-specific time windows for the introduction of highly-pathogenic avian influenza (HPAI) virus can be used to increase the efficiency of disease control measures such as contact tracing ...

Nguyen NM, Sung HW, Yun KJ, Park H, Yeo SJ. Genetic Characterization of a Novel North American-Origin Avian Influenza A (H6N5) Virus Isolated from Bean Goose of South Korea in 2018. Viruses. 2020;12(7):E774..  Abstract  
submitted by kickingbird at 13 days ago from Viruses. 2020;12(7):E774. (via https://pubmed.ncbi.nlm.nih.gov/32709116/)
The complex overlap in waterfowl migratory pathways across the world has established numerous occurrences of genetic reassortment and intercontinental spread of avian influenza virus (AIV) over long distances, ...

Wang S, Liang T, Luo Q, et al. H9N2 swine influenza virus infection-induced damage is mediated by TRPM2 channels in mouse pulmonary microvascular endothelial cells. Microb Pathog. 2020;104408.  Abstract  
submitted by kickingbird at 13 days ago from Microb Pathog. 2020;104408 (via https://www.sciencedirect.com/science/article/abs/pii/S08824)
Oxidative stress is implicated in the pathogenesis of influenza virus infection. Increasing evidences show that transient receptor potential melastatin 2 (TRPM2), a Ca2+-permeable non-selective cation ...

Sun Y, Zhang K, Qi H, et al. Computational Predicting the Human Infectivity of H7N9 Influenza Viruses Isolated from Avian Hosts. ransbound Emerg Dis. 2020;10.1111/tbed.13750.  Abstract  
submitted by kickingbird at 13 days ago from ransbound Emerg Dis. 2020;10.1111/tbed.13750 (via https://pubmed.ncbi.nlm.nih.gov/32706427/)
The genome composition of a given avian influenza virus is the primary determinant of its potential for cross-species transmission from birds to humans. Here we introduce a viral genome-based computational ...

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