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2017-12-19 6:15:31
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Herrera-Rodriguez J, Meijerhof T, Niesters HG, Stj. A novel peptide-based vaccine candidate with protective efficacy against influenza A in a mouse model. Virology 2017;515:21-28.  Abstract  
submitted by kickingbird at 18 hours ago from Virology 2017;515:21-28 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29223787/)
Current influenza vaccines mainly induce antibody responses to the variable hemagglutinin proteins of the virus strains included in the vaccine. Instead, a broadly protective influenza vaccine should aim ...

Ortiz JR, Hickling J, Jones R, Donabedian A, et al. Report on eighth WHO meeting on development of influenza vaccines that induce broadly protective and long-lasting immune responses: Chicago, USA, 23-24 August 2016. Vaccine 2017 Dec 5.  Abstract  
submitted by kickingbird at 18 hours ago from Vaccine 2017 Dec 5 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29221895/)
In August 2016, the World Health Organization (WHO) convened the "Eighth meeting on development of influenza vaccines that induce broadly protective and long-lasting immune responses" to discuss the regulatory ...

Turkington HL, Juozapaitis M, Tsolakos N, Corrales. Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins. J Virol 2017 Dec 13.  Abstract  
submitted by kickingbird at 18 hours ago from J Virol 2017 Dec 13 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29237829/)
Recently, two influenza A virus (FLUAV) genomes were identified in Central and South American bats. These sequences exhibit notable divergence from classical FLUAV counterparts, and functionally, bat FLUAV ...

Chauche C, Nogales A, Zhu H, Goldfarb D, et al. Mammalian adaptation of an avian influenza A virus involves stepwise changes in NS1. J Virol 2017 Dec 13.  Abstract  
submitted by kickingbird at 18 hours ago from J Virol 2017 Dec 13 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29237841/)
Influenza A viruses (IAVs) are common pathogens of birds that occasionally establish endemic infections in mammals. The processes and mechanisms that result in IAV mammalian adaptation are poorly understood. ...

Amodio D, Cotugno N, Macchiarulo G, Rocca S, et al. Quantitative Multiplexed Imaging Analysis Reveals a Strong Association between Immunogen-Specific B Cell Responses and Tonsillar Germinal Center Immune Dynamics in Children after Influenza Vaccination. J Immunol 2017 Dec 13.  Abstract  
submitted by kickingbird at 18 hours ago from J Immunol 2017 Dec 13 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29237774/)
Generation of Ag-specific humoral responses requires the orchestrated development and function of highly specialized immune cells in secondary lymphoid organs. We used a multiparametric approach combining ...

White MC, Lowen AC. Implications of segment mismatch for influenza A virus evolution. J Gen Virol 2017 Dec 15.  Abstract  
submitted by kickingbird at 18 hours ago from J Gen Virol 2017 Dec 15 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29244017/)
Influenza A virus (IAV) is an RNA virus with a segmented genome. These viral properties allow for the rapid evolution of IAV under selective pressure, due to mutation occurring from error-prone replication ...

Ryu S, Lim JS, Cowling BJ, Chun BC. Low risk of avian influenza A (H5N6) transmission to depopulation workers in Korea. Influenza Other Respir Viruses. 2017 Dec 13.  Abstract  
submitted by kickingbird at 2 days ago from Influenza Other Respir Viruses. 2017 Dec 13 (via http://onlinelibrary.wiley.com/doi/10.1111/irv.12530/abstrac)
An outbreak of highly pathogenic avian influenza A (H5N6) virus occurred between November 20, 2016 and March 1, 2017 in poultry farms, in the Gyeonggi Province, Republic of Korea. To identify the risk ...

Yang L, Zhu W, Li X, Chen M, et al. Genesis and Spread of Newly Emerged Highly Pathogenic H7N9 Avian Viruses in Mainland China. J Virol 2017;91.  Abstract  
submitted by kickingbird at 9 days ago from J Virol 2017;91 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28956760/)
The novel low-pathogenic avian influenza A H7N9 viruses (LPAI H7N9 viruses) have been a threat to public health since their emergence in 2013 because of the high rates of mortality and morbidity that they ...

Iwatsuki-Horimoto K, Nakajima N, Ichiko Y, Sakai-T. Syrian hamster as an animal model for the study of human influenza virus infection. J Virol 2017 Dec 6.  Abstract  
submitted by kickingbird at 9 days ago from J Virol 2017 Dec 6 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29212926/)
Ferrets and mice are frequently used as animal models for influenza research. However, ferrets are demanding in terms of housing space and handling, whereas mice are not naturally susceptible to infection ...

Zhong G, Le MQ, Lopes TJS, Halfmann P, et al. Mutations in the PA Protein of Avian H5N1 Influenza Viruses Affect Polymerase Activity and Mouse Virule. J Virol 2017 Dec 6.  Abstract  
submitted by kickingbird at 9 days ago from J Virol 2017 Dec 6 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29212927/)
To study the influenza viral determinants of pathogenicity, we characterized two highly pathogenic avian H5N1 influenza viruses isolated in Vietnam in 2012 (A/duck/Vietnam/QT1480/2012; QT1480) and 2013 ...

Xiao J, Rijal P, Schimanski L, Tharkeshwar AK, et. Characterization of an influenza virus pseudotyped with Ebolavirus glycoprotein. J Virol 2017 Dec 6.  Abstract  
submitted by kickingbird at 9 days ago from J Virol 2017 Dec 6 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29212933/)
We have produced a new Ebola virus pseudotype: E-S-FLU, which can be handled in biosafety level-1/2 containment for laboratory analysis. E-S-FLU is a single cycle influenza virus coated with Ebolavirus ...

Chen C, Liu L, Xiao Y, Cui S, et al.. Structural insight into a human neutralizing antibody against influenza virus H7N9. J Virol 2017 Dec 6.  Abstract  
submitted by kickingbird at 9 days ago from J Virol 2017 Dec 6 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29212936/)
Since its first emergence in East China in early 2013, many cases of avian influenza A H7N9 have been reported. The disease has extended to 22 provinces in mainland China and some surrounding areas. Strategies ...

Makvandi-Nejad S, Laurenson-Schafer H, Wang L, Wel. Lack of Truncated IFITM3 Transcripts in Cells Homozygous for the rs12252-C Variant That is Associated With Severe Influenza Infection. J Infect Dis 2017 Nov 30.  Abstract  
submitted by kickingbird at 9 days ago from J Infect Dis 2017 Nov 30 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29202190/)
Interferon-induced transmembrane 3 (IFITM3) is known to restrict the entry of a range of enveloped viruses. The single nucleotide polymorphism rs12252-C within IFITM3 has been shown to be associated with ...

Qi X, Zhang H, Xue T, Yang B, et al. Down-regulation of cellular protein heme oxygenase-1 inhibits proliferation of avian influenza virus H9N2 in chicken oviduct epithelial cells. J Gen Virol 2017 Dec 8.  Abstract  
submitted by kickingbird at 9 days ago from J Gen Virol 2017 Dec 8 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29219807/)
The pathogenesis of H9N2 subtype avian influenza virus (AIV) infection in hens is often related to oviduct tissue damage. Our previous study suggested that H9N2 AIV induces cellular apoptosis by activating ...

Kim HK, Kim HJ, Noh JY, Van Phan L, et al. Serological evidence of H5-subtype influenza A virus infection in indigenous avian and mammalian species in Korea. Arch Virol 2017 Dec 4.  Abstract  
submitted by kickingbird at 9 days ago from Arch Virol 2017 Dec 4 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29204739/)
In Korea, H5-subtype highly pathogenic avian influenza (HPAI) has caused huge economic losses in poultry farms through outbreaks of H5N1 since 2003, H5N8 since 2013 and H5N6 since 2016. Although it was ...

C Li, etc.,al. Genetic evolution of influenza H9N2 viruses isolated from various hosts in China from 1994 to 2013. Emerging Microbes & Infections (2017).  Abstract  
submitted by kickingbird at 10 days ago from Emerging Microbes & Infections (2017) (via http://www.nature.com/articles/emi201794)
Influenza H9N2 subtype viruses and their reassortants (such as H7N9) are posing increasing threats to birds and humans in China. During 2009–2013, multiple novel subtype viruses with H9N2 original genes ...

J Chen, etc.,al. Long term outcomes in survivors of epidemic Influenza A (H7N9) virus infection. Scientific Reports 7, Article number: 17275 (2017).  Abstract  
submitted by kickingbird at 10 days ago from Scientific Reports 7, Article number: 17275 (2017) (via https://www.nature.com/articles/s41598-017-17497-6)
Patients who survive influenza A (H7N9) virus infection are at risk of physical and psychological complications of lung injury and multi-organ dysfunction. However, there were no prospectively individualized ...

Iskandar VI, Sasaki Y, Yoshino N, Abubakar RZR, et. Optimization of trypsins for influenza A/H1N1 virus replication in MDCK SI-6 cells, a novel MDCK cell line. J Virol Methods 2017 Nov 16.  Abstract  
submitted by kickingbird at Nov, 26, 2017 from J Virol Methods 2017 Nov 16 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29155214/)
A cell-based vaccine production method for influenza virus may be an effective and more rapid alternative to egg-based systems. For high-yield virus production, the effect of bovine, porcine, fungal, and ...

Su WC, Yu WY, Huang SH, Lai MMC, et al. Ubiquitination of the Cytoplasmic Domain of Influenza A Virus M2 Protein is Crucial for Production of Infectious Virus Particles. J Virol 2017 Nov 22.  Abstract  
submitted by kickingbird at Nov, 26, 2017 from J Virol 2017 Nov 22 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29167343/)
Virus replication is mediated by interactions between virus and host. Here, we demonstrate that influenza A virus membrane protein 2 (M2) can be ubiquitinated. The lysine residue at position 78, which ...

Wan H, Qi L, Gao J, Couzens LK, et al. Comparison of the Efficacy of N9 Neuraminidase-specific Monoclonal Antibodies against Influenza A(H7N9) Virus Infection. J Virol 2017 Nov 22.  Abstract  
submitted by kickingbird at Nov, 26, 2017 from J Virol 2017 Nov 22 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29167344/)
The fifth wave of A(H7N9) virus infection in China from 2016 to 2017 caused great concern due to the large number of individuals infected, the isolation of drug-resistant viruses and emergence of highly ...

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