Belser JA, Barclay W, Barr I, Fouchier RAM, Matsuy. Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk Assessments. Emerg Infect Dis. 2018 Jun;24(6):965-971. Abstract
submitted by kickingbird at 1 days ago from Emerg Infect Dis. 2018 Jun;24(6):965-971 (via https://www.ncbi.nlm.nih.gov/pubmed/29774862)
The ferret transmission model is extensively used to assess the pandemic potential of emerging influenza viruses, yet experimental conditions and reported results vary among laboratories. Such variation ...
Ferguson L, Luo K, Olivier AK, Cunningham FL, Blac. Influenza D Virus Infection in Feral Swine Populations, United States. Emerg Infect Dis. 2018 Jun;24(6):1020-1028. Abstract
submitted by kickingbird at 1 days ago from Emerg Infect Dis. 2018 Jun;24(6):1020-1028 (via https://www.ncbi.nlm.nih.gov/pubmed/29774857)
Influenza D virus (IDV) has been identified in domestic cattle, swine, camelid, and small ruminant populations across North America, Europe, Asia, South America, and Africa. Our study investigated seroprevalence ...
Suttie A, Yann S, Y P, Tum S, Deng YM, Hul V, Horm. Detection of Low Pathogenicity Influenza A(H7N3) Virus during Duck Mortality Event, Cambodia, 2017. Emerg Infect Dis. 2018 Jun;24(6):1103-1107. Abstract
submitted by kickingbird at 1 days ago from Emerg Infect Dis. 2018 Jun;24(6):1103-1107 (via https://www.ncbi.nlm.nih.gov/pubmed/29774842)
In January 2017, an estimated 3,700 (93%) of 4,000 Khaki Campbell ducks (Anas platyrhynchos domesticus) died in Kampong Thom Province, Cambodia. We detected low pathogenicity avian influenza A(H7N3) virus ...
Zhu YC, etc.,al. Replication and Pathology of Duck Influenza Virus Subtype H9N2 in Chukar. Biomed Environ Sci. 2018 Apr;31(4):306-310.. Abstract
submitted by kickingbird at 1 days ago from Biomed Environ Sci. 2018 Apr;31(4):306-310. (via https://www.ncbi.nlm.nih.gov/pubmed/29773094)
To investigate the susceptibility of Chukars to duck avian influenza virus H9N2 and explore their role in interspecies transmission of influenza viruses. Chukars were inoculated with duck avian influenza ...
Jegaskanda S. The Potential Role of Fc-Receptor Functions in the Development of a Universal Influenza Vaccine. Vaccines (Basel). 2018 May 17;6(2). Abstract
submitted by kickingbird at 1 days ago from Vaccines (Basel). 2018 May 17;6(2) (via https://www.ncbi.nlm.nih.gov/pubmed/29772781)
Despite global vaccination efforts, influenza virus continues to cause yearly epidemics and periodic pandemics throughout most of the world. Many of us consider the generation of broader, potent and long-lasting ...
Zheng Y, etc.,al. Comparative analysis of MicroRNA expression in dog lungs infected with the H3N2 and H5N1 canine influenza viruses. Microb Pathog. 2018 May 14. Abstract
submitted by kickingbird at 1 days ago from Microb Pathog. 2018 May 14 (via https://www.ncbi.nlm.nih.gov/pubmed/29772263)
MicroRNAs, a class of noncoding RNAs 18 to 23 nucleotides (nt) in length, play critical roles in a wide variety of biological processes. The objective of this study was to examine differences in microRNA ...
Arafat N, Eladl AH, Marghani BH, Saif MA, El-Shafe. Enhanced infection of avian influenza virus H9N2 with infectious laryngeotracheitis vaccination in chickens. Vet Microbiol. 2018 Jun;219:8-16.. Abstract
submitted by kickingbird at 2 days ago from Vet Microbiol. 2018 Jun;219:8-16. (via https://www.ncbi.nlm.nih.gov/pubmed/29778208)
Avian influenza and infectious laryngeotracheitis viruses are common causes of respiratory diseases in chickens with economical importance worldwide. In this study, we investigated the effect of experimental ...
Ikematsu H, etc.,al. In vitro neuraminidase inhibitory concentration (IC50) of four neuraminidase inhibitors in the Japanese 2016-17 season: Comparison with the 2010-11 to 2015-16 seasons. J Infect Chemother. 2018 May 11. Abstract
submitted by kickingbird at 2 days ago from J Infect Chemother. 2018 May 11 (via https://www.ncbi.nlm.nih.gov/pubmed/29759897)
To assess the extent of susceptibility to the four most commonly used neuraminidase inhibitors (NAIs) in the viruses epidemic in the 2016-17 Japanese influenza season, we measured the 50% inhibitory concentration ...
Li Y, Sun L, Zheng W, Madina Mahesutihan, et al. Phosphorylation and dephosphorylation of threonine 188 in nucleoprotein is crucial for the replication of influenza A virus. Virology 2018;520:30-38. Abstract
submitted by kickingbird at 4 days ago from Virology 2018;520:30-38 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29775781/)
Nucleoprotein (NP) is a major component of the viral ribonucleoprotein (vRNP) complex that is responsible for viral replication, transcription and packaging of influenza A virus. Phosphorylation of NP ...
Venkatesh D, Poen MJ, Bestebroer TM, Scheuer RD, e. Avian influenza viruses in wild birds: virus evolution in a multi-host ecosystem. J Virol 2018 May 16.. Abstract
submitted by kickingbird at 4 days ago from J Virol 2018 May 16. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29769347/)
Wild ducks and gulls are the major reservoirs for avian influenza A viruses (AIVs). The mechanisms that drive AIV evolution are complex at sites where various duck and gull species from multiple flyways ...
Richards KA, Treanor JJ, Nayak JL, Sant AJ, et al.. Overarching Immunodominance Patterns and Substantial Diversity in Specificity and Functionality in the Circulating Human Influenza A and B CD4 T Cell Repertoire. J Infect Dis 2018 May 12. Abstract
submitted by kickingbird at 4 days ago from J Infect Dis 2018 May 12 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29762692/)
There is limited information on the antigen specificity and functional potential of the influenza-specific CD4 T cell repertoire in humans. Here, ELISPOT assays were used to examine circulating CD4 T cell ...
Califano D, Furuya Y, Metzger DW.. Effects of Influenza on Alveolar Macrophage Viability Are Dependent on Mouse Genetic Strain. J Immunol 2018 May 14. Abstract
submitted by kickingbird at 4 days ago from J Immunol 2018 May 14 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29760191/)
Secondary bacterial coinfections following influenza virus pose a serious threat to human health. Therefore, it is of significant clinical relevance to understand the immunological causes of this increased ...
Scott AB, Toribio JA, Singh M, Groves P. Low Pathogenic Avian Influenza Exposure Risk Assessment in Australian Commercial Chicken Farms. Front Vet Sci. 2018 Apr 26;5:68. Abstract
submitted by kickingbird at 7 days ago from Front Vet Sci. 2018 Apr 26;5:68 (via https://www.ncbi.nlm.nih.gov/pubmed/29755987)
This study investigated the pathways of exposure to low pathogenic avian influenza (LPAI) virus among Australian commercial chicken farms and estimated the likelihood of this exposure occurring using scenario ...
Lu C, Yin Y, Meng F, Dun Y, Pei K, Wang C. Discovery of (E)-1-amino-4-phenylbut-3-en-2-ol derivatives as novel neuraminidase inhibitors. Bioorg Med Chem Lett. 2018 May 4. pii: S0960-894X(. Abstract
submitted by kickingbird at 7 days ago from Bioorg Med Chem Lett. 2018 May 4. pii: S0960-894X( (via https://www.ncbi.nlm.nih.gov/pubmed/29748050)
Neuraminidase has been considered as an important target for designing agents against influenza viruses. In a discovery of anti-influenza agents with epigoitrin as the initial lead compound, a series of ...
Alymova IV, McCullers JA, Kamal RP, Vogel P. Virulent PB1-F2 residues: effects on fitness of H1N1 influenza A virus in mice and changes during evolution of human influenza A viruses. Sci Rep. 2018 May 10;8(1):7474.. Abstract
submitted by kickingbird at 7 days ago from Sci Rep. 2018 May 10;8(1):7474. (via https://www.ncbi.nlm.nih.gov/pubmed/29749408)
Specific residues of influenza A virus (IAV) PB1-F2 proteins may enhance inflammation or cytotoxicity. In a series of studies, we evaluated the function of these virulence-associated residues in the context ...
Perot BP, Boussier J, Yatim N. Autophagy diminishes the early interferon-β response to influenza A virus resulting in differential expression of interferon-stimulated genes. Cell Death Dis. 2018 May 10;9(5):539.. Abstract
submitted by kickingbird at 7 days ago from Cell Death Dis. 2018 May 10;9(5):539. (via https://www.ncbi.nlm.nih.gov/pubmed/29748576)
Influenza A virus (IAV) infection perturbs metabolic pathways such as autophagy, a stress-induced catabolic pathway that crosstalks with cellular inflammatory responses. However, the impact of autophagy ...
Wang Y, Li J, Yan W, Chen Q, Jiang Z, Zhang R. An active component containing pterodontic acid and pterodondiol isolated from Laggera pterodonta inhibits influenza A virus infection through the TLR7/MyD88/TRAF6/NF?κB signaling pathway. Mol Med Rep. 2018 May 2.. Abstract
submitted by kickingbird at 7 days ago from Mol Med Rep. 2018 May 2. (via https://www.ncbi.nlm.nih.gov/pubmed/29749442)
The influenza virus is a pathogen that can cause pandemic and epidemic outbreaks, and therefore represents a severe threat to human health. Antiviral drugs have an important role in the prevention and ...
Mandour YM, Breitinger U, Ma C, Wang J. Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7. Drug Des Devel Ther. 2018 Apr 30;12:1019-1031.. Abstract
submitted by kickingbird at 7 days ago from Drug Des Devel Ther. 2018 Apr 30;12:1019-1031. (via https://www.ncbi.nlm.nih.gov/pubmed/29750015)
Background: Adamantane-based compounds have been identified to interfere with the ion-channel activity of viroporins and thereby inhibit viral infection. To better understand the difference in the inhibition ...
Wang TT, Bournazos S, Ravetch JV. Immunological responses to influenza vaccination: lessons for improving vaccine efficacy. Curr Opin Immunol. 2018 May 10;53:124-129. Abstract
submitted by kickingbird at 7 days ago from Curr Opin Immunol. 2018 May 10;53:124-129 (via https://www.ncbi.nlm.nih.gov/pubmed/29753885)
A critical factor in the maturation of influenza vaccine responses is the nearly inevitable binding of vaccine antigens by exiting anti-influenza IgGs. These antigen-IgG immune complexes direct the response ...
Rudneva IA, Timofeeva TA, Mukasheva EA. Pleiotropic effects of hemagglutinin amino acid substitutions of influenza A(H1N1)pdm09 virus escape mutants. Virus Res. 2018 May 10. Abstract
submitted by kickingbird at 7 days ago from Virus Res. 2018 May 10 (via https://www.ncbi.nlm.nih.gov/pubmed/29753891)
In the present study we assessed pleiotropic characteristics of the antibody-selected mutations. We investigated pH optimum of fusion, temperatures of HA heat inactivation, in vivo and in vitro replication ...
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