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2019-3-22 19:31:34

Yasuhara A, et al. Antigenic drift originating from changes to the lateral surface of the neuraminidase head of influenza A virus. Nat Microbiol. 2019 Mar 18..  Abstract  
submitted by kickingbird at 1 days ago from Nat Microbiol. 2019 Mar 18. (via https://www.nature.com/articles/s41564-019-0401-1)
Influenza viruses possess two surface glycoproteins, haemagglutinin and neuraminidase (NA). Although haemagglutinin plays a major role as a protective antigen, immunity to NA also contributes to protection. ...

Hajam IA, Kim J, Lee JH. Intranasally administered polyethylenimine adjuvanted influenza M2 ectodomain induces partial protection against H9N2 influenza A virus infection in chickens. Vet Immunol Immunopathol. 2019 Mar;209:78-83..  Abstract  
submitted by kickingbird at 1 days ago from Vet Immunol Immunopathol. 2019 Mar;209:78-83. (via https://www.sciencedirect.com/science/article/pii/S016524271)
This study aimed to investigate whether intranasally coadministered four tandem copies of extracellular domains of M2 (M2e) and polyethyleneimine (PEI), a mucosal adjuvant, can protect chickens against ...

Criado MF, et al. Efficacy of novel recombinant fowlpox vaccine against recent Mexican H7N3 highly pathogenic avian influenza virus. Vaccine. 2019 Mar 15.  Abstract  
submitted by kickingbird at 1 days ago from Vaccine. 2019 Mar 15 (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Since 2012, H7N3 highly pathogenic avian influenza (HPAI) has produced negative economic and animal welfare impacts on poultry in central Mexico. In the present study, chickens were vaccinated with two ...

Nannetti G, et al. Potent and broad-spectrum cycloheptathiophene-3-carboxamide compounds that target the PA-PB1 interaction of influenza virus RNA polymerase and possess a high barrier to drug resistance. Antiviral Res. 2019 Mar 15..  Abstract  
submitted by kickingbird at 1 days ago from Antiviral Res. 2019 Mar 15. (via https://www.sciencedirect.com/science/article/pii/S016635421)
Influenza viruses are major respiratory pathogens responsible for both seasonal epidemics and occasional pandemics worldwide. The current available treatment options have limited efficacy and thus the ...

Dalcin D, Kwong JC. High-dose influenza vaccination. CMAJ. 2019 Mar 18;191(11):E313.  Abstract  
submitted by kickingbird at 1 days ago from CMAJ. 2019 Mar 18;191(11):E313 (via http://www.cmaj.ca/content/191/11/E313.long)
High-dose trivalent inactivated influenza vaccine (HD-TIV) contains 60 μg of hemagglutinin per strain, whereas standard-dose vaccines (SD-TIV) contain 15 μg. Given the burden of influenza A subtype H3N2 ...

Ma C, et al. Avian influenza A (H9N2) virus infections among poultry workers, swine workers, and the general population in Beijing, China, 2013-2016: A serological cohort study. Influenza Other Respir Viruses. 2019 Mar 18.  Abstract  
submitted by kickingbird at 3 days ago from Influenza Other Respir Viruses. 2019 Mar 18 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12641)
BACKGROUND: Few studies have reported on the seroprevalence of antibodies against avian influenza A (H9N2) virus and the incidence of these infections in the northern China and among swine workers.METHODS: ...

Abed Y, Fage C, Lagüe P, Carbonneau J, Papenburg J. Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada. Emerg Infect Dis. 2019 Apr;25(4):838-840.  Abstract  
submitted by kickingbird at 3 days ago from Emerg Infect Dis. 2019 Apr;25(4):838-840 (via https://wwwnc.cdc.gov/eid/article/25/4/18-1554_article)
We identified an influenza B isolate harboring a Gly407Ser neuraminidase substitution in an immunocompromised patient in Canada before antiviral therapy. This mutation mediated reduced susceptibility to ...

Chen Y, Wen Y. Spatiotemporal Distributions and Dynamics of Human Infections with the A H7N9 Avian Influenza Virus. Comput Math Methods Med. 2019 Feb 7;2019:9248246.  Abstract  
submitted by kickingbird at 3 days ago from Comput Math Methods Med. 2019 Feb 7;2019:9248246 (via https://www.hindawi.com/journals/cmmm/2019/9248246/)
In 2013 in mainland China, a novel avian influenza virus H7N9 began to infect humans and had aroused severe fatality in the infected humans, followed by the annual outbreaks. By methods of GIS and kriging ...

Paget C, Trottein F. Mechanisms of Bacterial Superinfection Post-influenza: A Role for Unconventional T Cells. Front Immunol. 2019 Mar 1;10:336..  Abstract  
submitted by kickingbird at 3 days ago from Front Immunol. 2019 Mar 1;10:336. (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0033)
Despite the widespread application of vaccination programs and antiviral drug treatments, influenza viruses are still among the most harmful human pathogens. Indeed, influenza results in significant seasonal ...

Pu Z, Yang J, Shen X, Irwin DM, Shen Y. Human-isolated H7N9 obtained internal genes from duck and human influenza viruses. J Infect. 2019 Mar 14..  Abstract  
submitted by kickingbird at 3 days ago from J Infect. 2019 Mar 14. (via https://www.journalofinfection.com/article/S0163-4453(19)300)
Recent studies in this journal revealed that some H7N9 viruses reassorted with duck AIVs, and then attained the ability to efficiently infect ducks.1,2 H7N9 AIVs have been endemic in chicken since their ...

Tang W, Li X, Hu CH, Zhu C, Li Z, Wu D, Wang T, He. Isolation of H8N4 avian influenza virus from wild birds in Shanghai, China.. Acta Virol. 2019;63(1):121-125..  Abstract  
submitted by kickingbird at 3 days ago from Acta Virol. 2019;63(1):121-125. (via https://www.ncbi.nlm.nih.gov/pubmed/30879322)
The H8 subtype viruses are rarely isolated from wild ducks. Shanghai is one of the important wintering or stopover sites on the East Asia-Australia Migration Flyway. An influenza virus, subtype H8N4, was ...

Moss R, et al. Anatomy of a seasonal influenza epidemic forecast. Commun Dis Intell (2018). 2019 Mar 15;43.  Abstract  
submitted by kickingbird at 3 days ago from Commun Dis Intell (2018). 2019 Mar 15;43 (via https://www.ncbi.nlm.nih.gov/pubmed/30879285)
Bayesian methods have been used to predict the timing of infectious disease epidemics in various settings and for many infectious diseases, including seasonal influenza. But integrating these techniques ...

Parvandeh S, et al. Multi-Level Model to Predict Antibody Response to Influenza Vaccine Using Gene Expression Interaction Network Feature Selection. Microorganisms. 2019 Mar 14;7(3)..  Abstract  
submitted by kickingbird at 4 days ago from Microorganisms. 2019 Mar 14;7(3). (via https://www.mdpi.com/2076-2607/7/3/79)
Vaccination is an effective prevention of influenza infection. However, certain individuals develop a lower antibody response after vaccination, which may lead to susceptibility to subsequent infection. ...

Voigt EA, et al. Sex Differences in Older Adults´ Immune Responses to Seasonal Influenza Vaccination. Front Immunol. 2019 Feb 27;10:180..  Abstract  
submitted by kickingbird at 4 days ago from Front Immunol. 2019 Feb 27;10:180. (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0018)
Background: Sex differences in immune responses to influenza vaccine may impact efficacy across populations. Methods: In a cohort of 138 older adults (50-74 years old), we measured influenza A/H1N1 antibody ...

Lee CC, et al. An Effective Neutralizing Antibody Against Influenza Virus H1N1 from Human B Cells. Sci Rep. 2019 Mar 14;9(1):4546.  Abstract  
submitted by kickingbird at 4 days ago from Sci Rep. 2019 Mar 14;9(1):4546 (via https://www.nature.com/articles/s41598-019-40937-4)
Influenza is a contagious acute respiratory disease caused by the influenza virus infection. Hemagglutinin (HA) is an important target in the therapeutic treatment and diagnostic detection of the influenza ...

Kolpe A, et al. Super-resolution microscopy reveals significant impact of M2e-specific monoclonal antibodies on influenza A virus filament formation at the host cell surface. Sci Rep. 2019 Mar 14;9(1):4450..  Abstract  
submitted by kickingbird at 4 days ago from Sci Rep. 2019 Mar 14;9(1):4450. (via https://www.ncbi.nlm.nih.gov/pubmed/30872764)
Influenza A virions are highly pleomorphic, exhibiting either spherical or filamentous morphology. The influenza A virus strain A/Udorn/72 (H3N2) produces copious amounts of long filaments on the surface ...

Pulit-Penaloza JA, Belser JA, Tumpey TM, Maines TR. Swine-origin H1 influenza viruses isolated from humans exhibit sustained infectivity in an aerosol state. Appl Environ Microbiol. 2019 Mar 15..  Abstract  
submitted by kickingbird at 5 days ago from Appl Environ Microbiol. 2019 Mar 15. (via https://www.ncbi.nlm.nih.gov/pubmed/30877121)
The relative importance of influenza virus transmission via aerosols is not fully understood, but experimental data suggests that aerosol transmission may represent a critical mode of influenza virus spread ...

Chong CR, et al. Safety of Inactivated Influenza Vaccine in Cancer Patients Receiving Immune Checkpoint Inhibitors (ICI). Clin Infect Dis. 2019 Mar 15..  Abstract  
submitted by kickingbird at 5 days ago from Clin Infect Dis. 2019 Mar 15. (via https://academic.oup.com/cid/advance-article-abstract/doi/10)
BACKGROUND: Cancer patients are at a higher risk for developing influenza (flu) related complications. It is unclear if the flu vaccine exacerbates immune events in patients treated with ICIs.METHODS: ...

Takizawa N, et al. Local structural changes of the influenza A virus ribonucleoprotein complex by single mutations in the specific residues involved in efficient genome packaging. Virology. 2019 Mar 7;531:126-140.  Abstract  
submitted by kickingbird at 5 days ago from Virology. 2019 Mar 7;531:126-140 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
The influenza A virus genome consists of eight single-stranded negative-sense RNA segments. The noncoding regions located at the 3'- and 5'- ends of each segment are necessary for genome packaging, and ...

Beerens N, et al. Genetic relationship between poultry and wild bird viruses during the highly pathogenic avian influenza H5N6 epidemic in the Netherlands, 2017~2018. Transbound Emerg Dis. 2019 Mar 15.  Abstract  
submitted by kickingbird at 5 days ago from Transbound Emerg Dis. 2019 Mar 15 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13169)
In the Netherlands, three commercial poultry farms and two hobby holdings were infected with highly pathogenic avian influenza (HPAI) H5N6 virus in the winter of 2017-2018. This H5N6 virus is a reassortant ...

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