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2025-3-26 1:07:11
Article

Liu CC, Ru YX, Li HR, Liu DJ, Liu JY, Zhao SL, Wu. Soluble influenza H3 trimer proteins enhance the breadth and potency of antibody response. Int J Biol Macromol. 2025 Mar 19;307(Pt 4):142240.  Abstract  
submitted by kickingbird at 17 hours ago from Int J Biol Macromol. 2025 Mar 19;307(Pt 4):142240 (via https://www.sciencedirect.com/science/article/abs/pii/S01418)
Seasonal influenza poses a continuing threat to public health. The effectiveness of the influenza vaccine varies across seasons, with protection against H3N2 being notably less reliable. A primary contributor ...

Chen C, Chen D, Du Y, Jiang D, Cao K, Yang M, Wu X. Global patterns and trends in deaths of influenza-associated lower respiratory infections from 1990 to 2019. Epidemiol Infect. 2025 Mar 24;153:e49.  Abstract  
submitted by kickingbird at 17 hours ago from Epidemiol Infect. 2025 Mar 24;153:e49 (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
This study examined global trends in influenza-associated lower respiratory infections (LRIs) deaths from 1990 to 2019 using data from the GBD 2019. The annual percentage change (APC) and average annual ...

Kawanishi N, Kinoshita Y, Reedy SE, Garvey M, Kamb. A comparative evaluation of seven commercial human influenza virus antigen detection kits for the diagnosis of equine influenza. Equine Vet J. 2025 Mar 24.  Abstract  
submitted by kickingbird at 17 hours ago from Equine Vet J. 2025 Mar 24 (via https://beva.onlinelibrary.wiley.com/doi/10.1111/evj.14500)
Background: Equine influenza virus (EIV) is one of the most important pathogens causing respiratory signs in equids. Rapid antigen detection (RAD) kits are useful for point-of-care testing because they ...

Sen TK, Jing L, Anand A, Zhang Ryan LZ, Ting HT, H. Unique Immune and Other Responses of Human Nasal Epithelial Cells Infected with H5N1 Avian Influenza Virus Compared to Seasonal Human Influenza A and B Viruses. Emerg Microbes Infect. 2025 Mar 24:2484330.  Abstract  
submitted by kickingbird at 18 hours ago from Emerg Microbes Infect. 2025 Mar 24:2484330 (via https://pubmed.ncbi.nlm.nih.gov/40126073/)
Highly pathogenic avian influenza (HPAI) virus (e.g. H5N1) infects the lower airway to cause severe infections, and constitute a prime candidate for the emergence of disease X. The nasal epithelium is ...

Nicole Lenz-Ajuh, etc.,al. [preprint]Impact of pH and temperature in dairy processing on the infectivity of H5N1 avian influenza viruses. https://doi.org/10.1101/2025.03.21.644501.  Abstract  
submitted by kickingbird at 3 days ago from https://doi.org/10.1101/2025.03.21.644501 (via https://www.biorxiv.org/content/10.1101/2025.03.21.644501v1)
Highly pathogenic avian influenza viruses (HPAIV) of subtype H5N1 (clade 2.3.4.4b) have crossed the species barrier and caused a mastitis-like infection in dairy cows. The high levels of infectious virus ...

Amber L Pillar, etc.,al. [preprint]Crucial role for iron metabolism in mediating influenza A virus infection and associated disease. https://doi.org/10.1101/2025.03.20.644262.  Abstract  
submitted by kickingbird at 3 days ago from https://doi.org/10.1101/2025.03.20.644262 (via https://www.biorxiv.org/content/10.1101/2025.03.20.644262v1)
Rationale and Objectives: Iron availability and metabolism are important in the pathogenesis of bacterial infections. More recently, links have been reported between iron and the severity of viral infections. ...

Ford, Colby T. et al. Large-scale computational modelling of H5 influenza variants against HA1-neutralising antibodies. eBioMedicine, Volume 114, 105632.  Abstract  
submitted by kickingbird at 5 days ago from eBioMedicine, Volume 114, 105632 (via https://www.thelancet.com/journals/ebiom/article/PIIS2352-39)
BackgroundThe United States Department of Agriculture has recently released reports that show samples collected from 2022 to 2025 of highly pathogenic avian influenza (H5N1) have been detected in mammals ...

Mingsheng Zhao, etc.,al. Genetic Evolution and Molecular Characteristics of Avian Influenza Viruses in Jining from 2018 to 2023. Front. Microbiol. Volume 16, 2025.  Abstract  
submitted by kickingbird at 5 days ago from Front. Microbiol. Volume 16, 2025 (via https://www.frontiersin.org/journals/microbiology/articles/1)
Objective This study aimed to analyze the genetic evolution and molecular characteristics of H5, H7, and H9 subtypes of avian influenza viruses in the external environment of poultry in Jining from 2018 ...

Sebastian Bittrich, etc.,al. Visualizing and analyzing 3D biomolecular structures using Mol* at RCSB.org: Influenza A H5N1 virus proteome case study. TOOLS FOR PROTEIN SCIENCE.  Abstract  
submitted by kickingbird at 5 days ago from TOOLS FOR PROTEIN SCIENCE (via https://onlinelibrary.wiley.com/doi/10.1002/pro.70093)
The easiest and often most useful way to work with experimentally determined or computationally predicted structures of biomolecules is by viewing their three-dimensional (3D) shapes using a molecular ...

David J Bacsik, etc.,al. [preprint]Validation of H5 influenza virus subtyping RT-qPCR assay and low prevalence of H5 detection in 2024-2025 influenza virus season. https://doi.org/10.1101/2025.03.17.25324122.  Abstract  
submitted by kickingbird at 5 days ago from https://doi.org/10.1101/2025.03.17.25324122 (via https://www.medrxiv.org/content/10.1101/2025.03.17.25324122v)
A sustained outbreak of H5N1 influenza virus among wild fowl and domestic livestock has caused more than 70 zoonotic infections in humans in the United States, including one death. The Centers for Disease ...

Daniel Janies, etc.,al. [preprint]Analyses of phylogenetics, natural selection, and protein structure of clade 2.3.4.4b H5N1 Influenza A reveal that recent viral lineages have evolved promiscuity in host range and improved r. https://doi.org/10.1101/2025.03.15.641219.  Abstract  
submitted by kickingbird at 5 days ago from https://doi.org/10.1101/2025.03.15.641219 (via https://www.biorxiv.org/content/10.1101/2025.03.15.641219v1)
H5N1 influenza has been circulating in birds from Eurasia and Africa for more than 146 years, but human infection has been sporadic. H5N1 (clade 2.3.4.4b) has recently infected hundreds of species of wild ...

David Scheibner, etc.,al. [preprint]Different genetic determinants for high virulence, transmission and replication of high pathogenicity H7N7 avian influenza virus in turkeys and chickens. https://doi.org/10.1101/2025.03.18.643940.  Abstract  
submitted by kickingbird at 5 days ago from https://doi.org/10.1101/2025.03.18.643940 (via https://www.biorxiv.org/content/10.1101/2025.03.18.643940v1)
High pathogenicity (HP) avian influenza viruses (AIV) generally evolve from low pathogenicity (LP) precursors after transmission from wild birds to chickens (Gallus gallus domesticus) and turkeys (Meleagris ...

Abdul Rahman A Saied, Boshra A El-Saeed. Infectiousness of raw (unpasteurised) milk from influenza H5N1-infected cows beyond the USA. The Lancet Microbe.  Abstract  
submitted by kickingbird at 5 days ago from The Lancet Microbe (via https://www.sciencedirect.com/science/article/pii/S266652472)
Pasteurisation has been proven to inactivate the influenza H5N1 virus, rendering pasteurised cow milk safe for consumers. In the USA, almost all (99%) of the commercial milk supply produced on dairy farms ...

Jessica A Belser, etc.,al. Ocular infectivity and replication of a clade 2.3.4.4b A(H5N1) influenza virus associated with human conjunctivitis in a dairy farm worker in the USA: an in-vitro and ferret study. The Lancet Microbe.  Abstract  
submitted by kickingbird at 5 days ago from The Lancet Microbe (via https://www.sciencedirect.com/science/article/pii/S266652472)
SummaryBackgroundThe human eye represents a potential site of influenza A virus (IAV) replication, and an entry point for the virus to reach the respiratory tract. The frequent detection of conjunctivitis ...

Yuan Liang, etc.,al. Epidemiological and Virological investigation of high pathogenicity avian influenza outbreaks in Danish poultry during 2020/2021 and 2021/2022. Research in Veterinary Science.  Abstract  
submitted by kickingbird at 5 days ago from Research in Veterinary Science (via https://www.sciencedirect.com/science/article/abs/pii/S00345)
Incursions and persistence of high pathogenicity avian influenza viruses (HPAIVs) in Europe have resulted in devastating epidemiological seasons in 2020/2021 and 2021/2022 compared to previous seasons. ...

Zhao C, Huang J, Zhang C, Wang Y, Zhang X, Liu S,. Characteristics of the First Domestic Duck-Origin H12N8 Avian Influenza Virus in China. International Journal of Molecular Sciences. 2025;.  Abstract  
submitted by kickingbird at 5 days ago from International Journal of Molecular Sciences. 2025; (via https://www.mdpi.com/1422-0067/26/6/2740)
The H12 subtypes of avian influenza viruses (AIVs) are globally prevalent in wild birds, occasionally spilling over into poultry. In this study, we isolated an H12N8 virus from ducks in a live poultry ...

Alnaanah SA, Qatamin AH, Mendes SB, O´Toole. Electro-active evanescent-wave cavity ring-down spectroscopy immunosensor for influenza virus detection. Biomed Opt Express. 2025 Feb 11;16(3):982-994.  Abstract  
submitted by kickingbird at 5 days ago from Biomed Opt Express. 2025 Feb 11;16(3):982-994 (via https://opg.optica.org/boe/fulltext.cfm?uri=boe-16-3-982&id=)
The early and accurate detection of viral pathogens is critical for effective disease management and public health safety. This study introduces an immunosensor that integrates an electro-active evanescent-wave ...

Turner HM, Fuller AK, Twining JP, Hitchener GR, Fa. Highly Pathogenic Avian Influenza Virus Exposure and Infection in Free-Ranging Bobcats (Lynx rufus) in New York, USA. J Wildl Dis. 2025 Mar 19.  Abstract  
submitted by kickingbird at 6 days ago from J Wildl Dis. 2025 Mar 19 (via https://pubmed.ncbi.nlm.nih.gov/40103422/)
Highly pathogenic H5N1 influenza A virus (HP H5N1) cases in wild mammals have been increasing globally. Carnivora has been the most affected mammal order; however, the extent of morbidity and mortality ...

Wong JY, Cheung JK, Presanis AM, De Angelis D, Iul. Assessing the impact of influenza epidemics in Hong Kong. J Infect Dis. 2025 Mar 19:jiaf140.  Abstract  
submitted by kickingbird at 6 days ago from J Infect Dis. 2025 Mar 19:jiaf140 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
Background: Assessing the impact of influenza epidemics provides useful information to assess both population and healthcare system burden and can inform prevention and control measures for seasonal epidemics, ...

Jones JC, Andreev K, Fabrizio TP, Bowman AS, Govor. Baloxavir improves disease outcomes in mice after intranasal or ocular infection with Influenza A virus H5N1-contaminated cow´s milk. Nat Microbiol. 2025 Mar 17.  Abstract  
submitted by kickingbird at 6 days ago from Nat Microbiol. 2025 Mar 17 (via https://www.nature.com/articles/s41564-025-01961-5)
Testing approved antivirals against A(H5N1) influenza viruses circulating in peridomestic species, including dairy cows, is critical to public health and pre-pandemic planning. It cannot be tested in humans ...

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