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2025-1-18 19:33:11
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Ray EL, Wang Y, Wolfinger RD, Reich NG. Flusion: Integrating multiple data sources for accurate influenza predictions. Epidemics. 2024 Dec 25;50:100810.  Abstract  
submitted by kickingbird at 8 hours ago from Epidemics. 2024 Dec 25;50:100810 (via https://www.sciencedirect.com/science/article/pii/S175543652)
Over the last ten years, the US Centers for Disease Control and Prevention (CDC) has organized an annual influenza forecasting challenge with the motivation that accurate probabilistic forecasts could ...

Sullivan SG, Khvorov A, Carolan L, Dowson L, Hadip. Antibody responses against influenza A decline with successive years of annual influenza vaccination. NPJ Vaccines. 2025 Jan 17;10(1):11.  Abstract  
submitted by kickingbird at 8 hours ago from NPJ Vaccines. 2025 Jan 17;10(1):11 (via https://www.nature.com/articles/s41541-024-01057-x)
Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around ...

Gong HH, Worley MJ, Carver KA, Godin CJ, Deng JC. Deficient neutrophil responses early in influenza infection promote viral replication and pulmonary inflammation. PLoS Pathog. 2025 Jan 17;21(1):e1012449.  Abstract  
submitted by kickingbird at 8 hours ago from PLoS Pathog. 2025 Jan 17;21(1):e1012449 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Neutrophils play key protective roles in influenza infections, yet excessive neutrophilic inflammation is a hallmark of acute lung injury during severe infections. Phenotypic heterogeneity is increasingly ...

Teo QW, Wang Y, Lv H, Oade MS, Mao KJ, Tan TJC, Hu. Probing the functional constraints of influenza A virus NEP by deep mutational scanning. Cell Rep. 2025 Jan 14;44(1):115196.  Abstract  
submitted by kickingbird at 19 hours ago from Cell Rep. 2025 Jan 14;44(1):115196 (via https://www.cell.com/cell-reports/fulltext/S2211-1247(24)015)
The influenza A virus nuclear export protein (NEP) is a multifunctional protein that is essential for the viral life cycle and has very high sequence conservation. However, since the open reading frame ...

Lambertucci, S.A., Santangeli, A. & Plaza, P.I. The threat of avian influenza H5N1 looms over global biodiversity. Nat. Rev. Biodivers. 1, 7–9 (2025).  Abstract  
submitted by kickingbird at 1 days ago from Nat. Rev. Biodivers. 1, 7–9 (2025) (via https://link.springer.com/article/10.1038/s44358-024-00008-7)
The highly pathogenic avian influenza H5N1 is an emerging and unexpected threat to many wild animal species, which has implications for ecological processes, ecosystem services and conservation of threatened ...

Yang, L., Fan, M. Reaction-advection-diffusion model of highly pathogenic avian influenza with behavior of migratory wild birds. J. Math. Biol. 90, 18 (2025).  Abstract  
submitted by kickingbird at 1 days ago from J. Math. Biol. 90, 18 (2025) (via https://link.springer.com/article/10.1007/s00285-024-02181-x)
Wild birds are one of the main natural reservoirs for avian influenza viruses, and their migratory behavior significantly influences the transmission of avian influenza. To better describe the migratory ...

Xue, Ruixue, Ma, Huiling, Jiang, Zixin, Xing, Linl. Diversity of the H9N2 Avian Influenza Virus in Shandong Province, China. Transboundary and Emerging Diseases, 2025, 1432483.  Abstract  
submitted by kickingbird at 1 days ago from Transboundary and Emerging Diseases, 2025, 1432483 (via https://onlinelibrary.wiley.com/doi/10.1155/tbed/1432483)
H9N2 avian influenza virus (AIV) is one of the main pathogens causing respiratory disease in chicken; however, differentiating this virus from infectious bronchitis virus (IBV) and newcastle disease virus ...

Duong MH, Phan TNU, Nguyen TH, Ho NHN, Nguyen TN,. Human Infection with Avian Influenza A(H9N2) Virus, Vietnam, April 2024. Emerg Infect Dis. Feb 2025.  Abstract  
submitted by kickingbird at 1 days ago from Emerg Infect Dis. Feb 2025 (via https://wwwnc.cdc.gov/eid/article/31/2/24-1146_article)
In April 2024, Vietnam confirmed its first human case of influenza A(H9N2) in a 37-year-old man, marking a critical point in regional infectious disease monitoring and response. This case underscores the ...

Zhang C, Hou J, Li Z, Shen Q, Bai H, Chen L, Shen. PROTAR Vaccine 2.0 generates influenza vaccines by degrading multiple viral proteins. Nat Chem Biol. 2025 Jan 15.  Abstract  
submitted by kickingbird at 1 days ago from Nat Chem Biol. 2025 Jan 15 (via https://www.nature.com/articles/s41589-024-01813-z)
Manipulating viral protein stability using the cellular ubiquitin-proteasome system (UPS) represents a promising approach for developing live-attenuated vaccines. The first-generation proteolysis-targeting ...

Shen J, Li J, Shen Q, Hou J, Zhang C, Bai H, Ai X,. Proteolysis-targeting influenza vaccine strains induce broad-spectrum immunity and in vivo protection. Nat Microbiol. 2025 Jan 15.  Abstract  
submitted by kickingbird at 1 days ago from Nat Microbiol. 2025 Jan 15 (via https://www.nature.com/articles/s41564-024-01908-2)
Generating effective live vaccines from intact viruses remains challenging owing to considerations of safety and immunogenicity. Approaches that can be applied in a systematic manner are needed. Here we ...

Ma W, Ren C, Shi L, Meng B, Feng Y, Zhang Y. Isoleucine at position 137 of Hemagglutinin acts as a Mammalian adaptation marker of H9N2 Avian influenza virus. Emerg Microbes Infect. 2025 Jan 16:2455597.  Abstract  
submitted by kickingbird at 1 days ago from Emerg Microbes Infect. 2025 Jan 16:2455597 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
The H9N2 subtype of avian influenza virus (AIV) is widely distributed among poultry and wild birds and is also a threat to humans. During AIV active surveillance in Liaoning province from 2015 to 2016, ...

Goel V, Ding J, Hatuwal B, Giri E, Deliberto TJ, L. Ecological Drivers of Evolution of Swine Influenza in the United States: A Review. Emerg Microbes Infect. 2025 Jan 16:2455598.  Abstract  
submitted by kickingbird at 1 days ago from Emerg Microbes Infect. 2025 Jan 16:2455598 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
Influenza A viruses (IAVs) pose a major public health threat due to their wide host range and pandemic potential. Pigs have been proposed as "mixing vessels" for avian, swine, and human IAVs, significantly ...

Gert Zimmer, etc.,al. [preprint]Immunization with a novel RNA replicon vaccine confers long-lasting protection against H5N1 avian influenza virus in 24 bird species. ttps://doi.org/10.1101/2025.01.15.633174.  Abstract  
submitted by kickingbird at 2 days ago from ttps://doi.org/10.1101/2025.01.15.633174 (via https://www.biorxiv.org/content/10.1101/2025.01.15.633174v1)
Highly pathogenic avian influenza viruses (HPAIV) of subtype H5N1 (clade 2.3.4.4b) have spread worldwide and caused the death of hundreds of millions of wild birds and domestic poultry. Moreover, spill ...

Bia P, Losardo M, Manna A, Brusaferro S, Privitera. Selected microwave irradiation effectively inactivates airborne avian influenza A(H5N1) virus. Sci Rep. 2025 Jan 15;15(1):2021.  Abstract  
submitted by kickingbird at 2 days ago from Sci Rep. 2025 Jan 15;15(1):2021 (via https://www.nature.com/articles/s41598-025-85376-6)
The highly pathogenic avian influenza A(H5N1) virus threatens animal and human health globally. Innovative strategies are crucial for mitigating risks associated with airborne transmission and preventing ...

Jonathan D. Baghdadi, Deborah Grady, Daniel J. Mor. The Limited Role for Antiviral Therapy in Influenza. JAMA Intern Med.  Abstract  
submitted by kickingbird at 2 days ago from JAMA Intern Med (via https://jamanetwork.com/journals/jamainternalmedicine/articl)
Influenza is associated with substantial morbidity and mortality. Given this, antiviral therapy is commonly prescribed in an effort to prevent these outcomes. We therefore found it surprising that antivirals ...

Rosenke, K., Giffin, A., Kaiser, F. et al. Pathogenesis of bovine H5N1 clade 2.3.4.4b infection in Macaques. Nature (2025).  Abstract  
submitted by kickingbird at 2 days ago from Nature (2025) (via https://www.nature.com/articles/s41586-025-08609-8)
Since early 2022 highly pathogenic avian influenza (HPAI) H5N1 virus infections have been reported in wild aquatic birds and poultry throughout the United States (US) with spillover into several mammalian ...

Victoria Meliopoulos, etc.,al. [preprint]Susceptibility of bovine respiratory and mammary epithelial cells to avian and mammalian derived clade 2.3.4.4b H5N1 highly pathogenic avian influenza viruses. https://doi.org/10.1101/2025.01.09.632235.  Abstract  
submitted by kickingbird at 3 days ago from https://doi.org/10.1101/2025.01.09.632235 (via https://www.biorxiv.org/content/10.1101/2025.01.09.632235v1)
Zoonotic transmission of avian influenza viruses into mammals is relatively rare due to anatomical differences in the respiratory tract between species. Recently, clade 2.3.4.4b highly pathogenic H5N1 ...

LI Shan, DONG Hui, YAO Xue, et al. Genetic Diversity of H10N3 Avian Influenza Virus Isolated from Anhui Province, China. Chin J Virol, 2024, 40(05): 1022-1032.  Abstract  
submitted by kickingbird at 3 days ago from Chin J Virol, 2024, 40(05): 1022-1032
In April 2021,the first human case of infection by the H10N3 subtype avian influenza virus (AIV)was identified in Jiangsu,China. The genetic diversity and molecular characterizations of H10N3 subtype AIV ...

WANG Shenjiao, QI Xian, YU Huiyan, DENG Fei, HUANG. Molecular origion of human infection with a novel avian influenza A H10N3 virus in China, 2021. Microbiology China, 2023, 50(3): 1231-1244..  Abstract  
submitted by kickingbird at 3 days ago from Microbiology China, 2023, 50(3): 1231-1244. (via http://journals.im.ac.cn/wswxtbcn)
[Background] Since the human infection with avian influenza that occurred in Hong Kong in 1997, avian influenza virus has become a major threat to human health and public health. [Objective] To perform ...

Hawman, D.W., Tipih, T., Hodge, E. et al. Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice. Nat Commun 16, 655 (2025).  Abstract  
submitted by kickingbird at 3 days ago from Nat Commun 16, 655 (2025) (via https://link.springer.com/article/10.1038/s41467-024-55546-7)
The ongoing circulation of influenza A H5N1 in the United States has raised concerns of a pandemic caused by highly pathogenic avian influenza. Although the United States has stockpiled and is prepared ...

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