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2019-7-23 3:44:34
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Sun X, et al. Identification of key hemagglutinin residues responsible for cleavage, acid stability, and virulence of fifth-wave highly pathogenic avian influenza A(H7N9) viruses. Virology. 2019 Jul 12;535:232-240.  Abstract  
submitted by kickingbird at 13 hours ago from Virology. 2019 Jul 12;535:232-240 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
We previously demonstrated that despite no airborne transmissibility increase compared to low pathogenic avian influenza viruses, select human isolates of highly pathogenic avian influenza A(H7N9) virus ...

Hao X, et al. The PB2 and M genes of genotype S H9N2 virus contribute to the enhanced fitness of H5Nx and H7N9 avian influenza viruses in chickens. Virology. 2019 Jul 8;535:218-226.  Abstract  
submitted by kickingbird at 13 hours ago from Virology. 2019 Jul 8;535:218-226 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Genotype S H9N2 viruses frequently donate their internal genes to facilitate the generation of novel influenza viruses, e.g., H5N6, H7N9, and H10N8, which have caused human infection. Genotype S was originated ...

AlIbrahim M, et al. Molecular epidemiology and genetic characterization of influenza B virus in Lebanon during 2016~2018. Infect Genet Evol. 2019 Jul 17:103969.  Abstract  
submitted by kickingbird at 13 hours ago from Infect Genet Evol. 2019 Jul 17:103969 (via https://www.sciencedirect.com/science/article/pii/S156713481)
BACKGROUND: Influenza B viruses are a major cause of serious acute respiratory infections in humans.METHODS: Nasopharyngeal swabs were collected from subjects with influenza-like illness during October ...

Dahmani I, Ludwig K, Chiantia S. Influenza A matrix protein M1 induces lipid membrane deformation via protein multimerization. Biosci Rep. 2019 Jul 19.  Abstract  
submitted by kickingbird at 13 hours ago from Biosci Rep. 2019 Jul 19 (via http://bioscirep.org/lookup/doi/10.1042/BSR20191024)
The matrix protein M1 of the Influenza A virus is supposed to mediate viral assembly and budding at the plasma membrane (PM) of infected cells. In order for a new viral particle to form, the PM lipid bilayer ...

An J, Li J, Wang Y, Wang J, Li Q, Zhou H, et al. A Homeostasis Hypothesis of Avian Influenza Resistance in Chickens. Genes (Basel). 2019 Jul 17;10(7)..  Abstract  
submitted by kickingbird at 2 days ago from Genes (Basel). 2019 Jul 17;10(7). (via https://www.mdpi.com/2073-4425/10/7/543)
Avian influenza has caused significant damage to the poultry industry globally. Consequently, efforts have been made to elucidate the disease mechanisms as well as the mechanisms of disease resistance. ...

Abed Y, et al. The Val430Ile neuraminidase (NA) substitution, identified in influenza B virus isolates, impacts the catalytic 116Arg residue causing reduced susceptibility to NA inhibitors. Antiviral Res. 2019 Jul 16:104561.  Abstract  
submitted by kickingbird at 2 days ago from Antiviral Res. 2019 Jul 16:104561 (via https://www.sciencedirect.com/science/article/pii/S016635421)
As part of a 2015-2018 clinical trial of peramivir treatment for acute influenza infections in the elderly, an influenza B/Yamagata/16/1988-like isolate harbouring a Val430Ile neuraminidase (NA) substitution ...

Sedeyn K, Saelens X. New antibody-based prevention and treatment options for influenza. Antiviral Res. 2019 Jul 16:104562.  Abstract  
submitted by kickingbird at 2 days ago from Antiviral Res. 2019 Jul 16:104562 (via https://www.sciencedirect.com/science/article/pii/S016635421)
The antigenic diversity of human influenza viruses represents a challenge to the development of vaccines with durable immune protection. In addition, small molecule anti-influenza viral drugs can bring ...

Shi N, et al. Interventions in live poultry markets for the control of avian influenza: A systematic review and meta-analysis. J Infect Dis. 2019 Jul 17..  Abstract  
submitted by kickingbird at 2 days ago from J Infect Dis. 2019 Jul 17. (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
BACKGROUND: This review aimed to provide constructive suggestions for the control and management of avian influenza through quantitative and qualitative evaluation of the impact of different live poultry ...

Cao Z, et al. Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China. PLoS One. 2019 Jul 19;14(7):e0217607.  Abstract  
submitted by kickingbird at 2 days ago from PLoS One. 2019 Jul 19;14(7):e0217607 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Southern China is considered an important source of influenza virus pandemics because of the large, diverse viral reservoirs in poultry and swine. To examine the trend in influenza A virus of swine (IAV-S), ...

Pawestri HA, et al. Viral Factors Associated With the High Mortality Related to Human Infections With Clade 2.1 Influenza A/H5N1 Virus in Indonesia. Clin Infect Dis. 2019 Apr 26.  Abstract  
submitted by kickingbird at 2 days ago from Clin Infect Dis. 2019 Apr 26 (via https://academic.oup.com/cid/advance-article-abstract/doi/10)
BACKGROUND: Since their emergence in Indonesia in 2005, 200 human infections with clade 2.1 highly pathogenic avian influenza A/H5N1 virus have been reported, associated with exceptionally high mortality ...

Chen Y, Zhang Y, Xu Z, Wang X, Lu J, Hu W. Avian Influenza A (H7N9) and related Internet search query data in China. Sci Rep. 2019 Jul 18;9(1):10434.  Abstract  
submitted by kickingbird at 2 days ago from Sci Rep. 2019 Jul 18;9(1):10434 (via https://www.nature.com/articles/s41598-019-46898-y)
The use of Internet-based systems for infectious disease surveillance has been increasingly explored in recent years. However, few studies have used Internet search query or social media data to monitor ...

Music N, et al. Repeated vaccination against matched H3N2 influenza virus gives less protection than single vaccination in ferrets. NPJ Vaccines. 2019 Jul 9;4:28..  Abstract  
submitted by kickingbird at 3 days ago from NPJ Vaccines. 2019 Jul 9;4:28. (via https://www.nature.com/articles/s41541-019-0123-7)
Epidemiological studies suggest that humans who receive repeated annual immunization with influenza vaccine are less well protected against influenza than those who receive vaccine in the current season ...

Minagawa Y, Ueno H, Tabata KV, Noji H. Mobile imaging platform for digital influenza virus counting. Lab Chip. 2019 Jul 17.  Abstract  
submitted by kickingbird at 3 days ago from Lab Chip. 2019 Jul 17 (via https://pubs.rsc.org/en/content/articlelanding/2019/LC/C9LC0)
Droplet-based digital bioassays enable highly sensitive and quantitative analysis of biomolecules, and are thought to be suitable for point-of-care diagnosis. However, digital bioassays generally require ...

Hinkula J, et al. Long-Lasting Mucosal and Systemic Immunity against Influenza A Virus Is Significantly Prolonged and Protective by Nasal Whole Influenza Immunization with Mucosal Adjuvant N3 and DNA-Plasmid Expressing. Vaccines (Basel). 2019 Jul 16;7(3)..  Abstract  
submitted by kickingbird at 3 days ago from Vaccines (Basel). 2019 Jul 16;7(3). (via https://www.mdpi.com/2076-393X/7/3/64)
Background: Vaccination is commonly used to prevent and control influenza infection in humans. However, improvements in the ease of delivery and strength of immunogenicity could markedly improve herd immunity. ...

Von Holle TA, Moody MA. Influenza and Antibody-Dependent Cellular Cytotoxicity. Front Immunol. 2019 Jun 25;10:1457.  Abstract  
submitted by kickingbird at 3 days ago from Front Immunol. 2019 Jun 25;10:1457 (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0145)
Despite the availability of yearly vaccinations, influenza continues to cause seasonal, and pandemic rises in illness and death. An error prone replication mechanism results in antigenic drift and viral ...

Hao XY, Li FD, Lv Q, Xu YF, Han YL, Gao H. Establishment of BALB/C mouse models of influenza A H1N1 aerosol inhalation. J Med Virol. 2019 Jul 18.  Abstract  
submitted by kickingbird at 3 days ago from J Med Virol. 2019 Jul 18 (via https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25550)
Influenza A (H1N1) is a rapidly spreading acute respiratory illness that remains a worldwide burden on public health. To simulate natural infection routes, BALB/C mice were challenged with the H1N1 virus ...

Chen R, et al. Characterization of viral genomic mutations in novel influenza A (H7N9)-infected patients: the association between oseltamivir-resistant variants and viral shedding duration. Virus Genes. 2019 Jul 13.  Abstract  
submitted by kickingbird at 6 days ago from Virus Genes. 2019 Jul 13 (via https://link.springer.com/article/10.1007%2Fs11262-019-01678)
Since February 2013, human infections with the novel influenza A H7N9 virus have occurred in eastern China. It is important to detect mutations in viral genes and analyze the clinical features of patients ...

Gao W, et al. Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cells. J Gen Virol. 2019 Jul 15..  Abstract  
submitted by kickingbird at 6 days ago from J Gen Virol. 2019 Jul 15. (via https://jgv.microbiologyresearch.org/content/journal/jgv/10.)
Adaptation of PB2 protein is important for the establishment of avian influenza viruses in mammalian hosts. Here, we identify I292V as the prevalent mutation in PB2 of circulating avian H9N2 and pandemic ...

Chen J, et al. Circulation, Evolution and Transmission of Highly Pathogenic Avian Influenza A (H5N8) virus, 2016~2018. J Infect. 2019 Jul 12.  Abstract  
submitted by kickingbird at 6 days ago from J Infect. 2019 Jul 12 (via https://www.journalofinfection.com/article/S0163-4453(19)302)
OBJECTIVES: A second wave of highly pathogenic avian influenza A virus (HPAIV) H5N8 clade 2.3.4.4 has spread globally, causing outbreaks among wild birds and domestic poultry since autumn 2016. The circulation ...

Danier J, et al. Clinical Presentation of Influenza in Children 6 to 35 Months of Age: Findings From a Randomized Clinical Trial of Inactivated Quadrivalent Influenza Vaccine. Pediatr Infect Dis J. 2019 Aug;38(8):866-872.  Abstract  
submitted by kickingbird at 6 days ago from Pediatr Infect Dis J. 2019 Aug;38(8):866-872 (via https://insights.ovid.com/crossref?an=00006454-201908000-000)
BACKGROUND: In an exploratory analysis of an inactivated quadrivalent influenza vaccine (IIV4) trial in children 6-35 months without risk factors for influenza, we evaluated clinical presentation of influenza ...

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