Sch?n J, Breithaupt A, H?per D, King J, Pohlmann A. Neuraminidase-associated plasminogen recruitment enables systemic spread of natural avian Influenza viruses H3N1. PLoS Pathog. 2021 Apr 23;17(4):e1009490. Abstract
submitted by kickingbird at Apr, 24, 2021 from PLoS Pathog. 2021 Apr 23;17(4):e1009490 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Repeated outbreaks due to H3N1 low pathogenicity avian influenza viruses (LPAIV) in Belgium were associated with unusually high mortality in chicken in 2019. Those events caused considerable economic losses ... Adel A, Mosaad Z, Shalaby AG, Selim K, Samy M, Abd. Molecular evolution of the hemagglutinin gene and epidemiological insight into low-pathogenic avian influenza H9N2 viruses in Egypt. Res Vet Sci. 2021 Apr 14;136:540-549. Abstract
submitted by kickingbird at Apr, 24, 2021 from Res Vet Sci. 2021 Apr 14;136:540-549 (via https://www.sciencedirect.com/science/article/abs/pii/S00345)
Despite the low pathogenicity of the H9N2 avian influenza viruses, they can induce severe economic losses in various poultry sectors in conjunction with other factors. In Egypt, low-pathogenic avian influenza ... Kubota-Koketsu R, Yunoki M, Okuno Y, Ikuta K. Virus Neutralization by Human Intravenous Immunoglobulin Against Influenza Virus Subtypes A/H5 and A/H7. Biologics. 2021 Apr 13;15:87-94. Abstract
submitted by kickingbird at Apr, 22, 2021 from Biologics. 2021 Apr 13;15:87-94 (via https://www.dovepress.com/virus-neutralization-by-human-intr)
Purpose: Highly pathogenic avian influenza viruses are a threat to human health. Although donor populations have not experienced pandemic, they have been immunized by natural infections and/or vaccinations ... Gao J, Wan H, Li X, Rakic Martinez M, Klenow L, Ga. Balancing the influenza neuraminidase and hemagglutinin responses by exchanging the vaccine virus backbone. PLoS Pathog. 2021 Apr 19;17(4):e1009171. Abstract
submitted by kickingbird at Apr, 20, 2021 from PLoS Pathog. 2021 Apr 19;17(4):e1009171 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Virions are a common antigen source for many viral vaccines. One limitation to using virions is that the antigen abundance is determined by the content of each protein in the virus. This caveat especially ... Peng C, Zhao P, Jun C, Zhu J, Li Q, Zhao H, Li Y,. Characterization of Four Novel H5N6 Avian Influenza Viruses with the Internal Genes from H5N1 and H9N2 Viruses and Experimental Challenge of Chickens Vaccinated with Current Commercially Available H5. Transbound Emerg Dis. 2021 Apr 19. Abstract
submitted by kickingbird at Apr, 20, 2021 from Transbound Emerg Dis. 2021 Apr 19 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14110)
Since 2014, highly pathogenic avian influenza H5N6 viruses have been responsible for outbreaks in poultry. In this study, four H5N6 virus strains were isolated from fecal samples of sick white ducks and ... Nolan KE, Baer LA, Karekar P, Nelson AM, Stanford. Metabolic shifts modulate lung injury caused by infection with H1N1 influenza A virus. Virology. 2021 Apr 6;559:111-119. Abstract
submitted by kickingbird at Apr, 19, 2021 from Virology. 2021 Apr 6;559:111-119 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza A virus (IAV) infection alters lung epithelial cell metabolism in vitro by promoting a glycolytic shift. We hypothesized that this shift benefits the virus rather than the host and that inhibition ... Nenasheva VV, Nikitenko NA, Stepanenko EA, Makarov. Human TRIM14 protects transgenic mice from influenza A viral infection without activation of other innate immunity pathways. Genes Immun. 2021 Apr 16. Abstract
submitted by kickingbird at Apr, 18, 2021 from Genes Immun. 2021 Apr 16 (via https://pubmed.ncbi.nlm.nih.gov/33864033/)
TRIM14 is an important component of innate immunity that defends organism from various viruses. It was shown that TRIM14 restricted influenza A virus (IAV) infection in cell cultures in an interferon-independent ... Uprety T, Sreenivasan CC, Bhattarai S, Wang D, Kau. Isolation and development of bovine primary respiratory cells as model to study influenza D virus infection. Virology. 2021 Apr 11;559:89-99. Abstract
submitted by kickingbird at Apr, 18, 2021 from Virology. 2021 Apr 11;559:89-99 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza D virus (IDV) is a novel type of influenza virus that infects and causes respiratory illness in bovines. Lack of host-specific in vitro model that can recapitulate morphology and physiology of ... Chiem K, López-García D, Ortego J, Martinez-Sobrid. Identification of amino acid residues required for inhibition of host gene expression by influenza A/Viet Nam/1203/2004 H5N1 PA-X. J Virol. 2021 Apr 14:JVI.00408-21. Abstract
submitted by kickingbird at Apr, 16, 2021 from J Virol. 2021 Apr 14:JVI.00408-21 (via https://jvi.asm.org/content/early/2021/04/08/JVI.00408-21)
PA-X is a non-structural protein of influenza A virus (IAV), which is encoded by the polymerase acidic (PA) N-terminal region that contains a C-terminal +1 frameshifted sequence. IAV PA-X protein modulates ... Zhirnov OP, Chlanda P. The cleavage of spike protein НА0→НА1/HA2 by trypsin permits activation of the M2 channel without its proteolytic cleavage in the influenza A virus. Virology. 2021 Apr 1;559:86-88. Abstract
submitted by kickingbird at Apr, 14, 2021 from Virology. 2021 Apr 1;559:86-88 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
M2 plays numerous regulatory roles in influenza A virus infection confirming the old adage: "a little body often harbors a great sense". The comment here demonstrates that a small viral protein M2, having ... Khan A, Jahejo AR, Qiao ML, Han XY, Cheng QQ, Mang. NF-кB pathway genes expression in chicken erythrocytes infected with Avian Influenza virus subtype H9N2. Br Poult Sci. 2021 Apr 12. Abstract
submitted by kickingbird at Apr, 14, 2021 from Br Poult Sci. 2021 Apr 12 (via https://www.tandfonline.com/doi/abs/10.1080/00071668.2021.19)
1. Chicken erythrocytes in blood vessels are the most abundant circulating cells, which participate in the host's immune responses. The transcription factor nuclear factor kappa B (NF-κB) plays a vital ... Seekings AH, Warren CJ, Thomas SS, Mahmood S, Jame. Highly pathogenic avian influenza virus H5N6 (clade 2.3.4.4b) has a preferable host tropism for waterfowl reflected in its inefficient transmission to terrestrial poultry. Virology. 2021 Mar 25;559:74-85. Abstract
submitted by kickingbird at Apr, 13, 2021 from Virology. 2021 Mar 25;559:74-85 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Highly-pathogenic avian influenza virus (HPAIV) H5N6 (clade 2.3.4.4b) incurred into Europe in late 2017 and was predominantly detected in wild birds, with very few terrestrial poultry cases. Pekin ducks ... Zhang X, Li Y, Jin S, Zhang Y, Sun L, Hu X, Zhao M. PB1 S524G mutation of wild bird-origin H3N8 influenza A virus enhances virulence and fitness for transmission in mammals. Emerg Microbes Infect. 2021 Apr 12:1-46. Abstract
submitted by kickingbird at Apr, 13, 2021 from Emerg Microbes Infect. 2021 Apr 12:1-46 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1)
Influenza H3N8 viruses have been recovered frequently from wild bird species， including Anseriformes (primarily from migratory ducks) and Charadriiformes (primarily from shorebirds). However, little attention ... Tu YH, Guo Y, Ji S, Shen JL, Fei GH. The Influenza A Virus H3N2 Triggers the Hypersusceptibility of Airway Inflammatory Response via Activating the lncRNA TUG1/miR-145-5p/NF-κB Pathway in COPD. Front Pharmacol. 2021 Feb 22;12:604590. Abstract
submitted by kickingbird at Apr, 13, 2021 from Front Pharmacol. 2021 Feb 22;12:604590 (via https://www.frontiersin.org/articles/10.3389/fphar.2021.6045)
Background: Patients with chronic obstructive pulmonary disease (COPD) are more susceptible to influenza A virus (IAV) with more severe symptoms, yet the underlying molecular mechanisms of the hypersusceptibility ... Chaudhry M, Rashid HB, Thrusfield M, Eisler MC, We. Serosurvey of Avian Influenza Viruses (H5, H7, and H9) and Associated Risk Factors in Backyard Poultry Flocks of Lahore District, Pakistan. Front Vet Sci. 2021 Mar 24;8:631164. Abstract
submitted by kickingbird at Apr, 13, 2021 from Front Vet Sci. 2021 Mar 24;8:631164 (via https://www.frontiersin.org/articles/10.3389/fvets.2021.6311)
Rural poultry constitutes 56% of the total poultry population in Pakistan; however, epidemiological information about avian influenza viruses (AIVs) in backyard poultry flocks is lacking. A cross-sectional ... Deng J, Lu C, Liu C, Oveissi S, Fairlie WD, Lee EF. Influenza A virus infection-induced macroautophagy facilitates MHC class II-restricted endogenous presentation of an immunodominant viral epitope. FEBS J. 2020 Dec 5. Abstract
submitted by kickingbird at Apr, 12, 2021 from FEBS J. 2020 Dec 5 (via https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.15654)
CD4+ T cells recognize peptides presented by major histocompatibility complex class II molecules (MHC-II). These peptides are generally derived from exogenous antigens. Macroautophagy has been reported ... Qi Y, Guo W, Liu C, Li S, Chen X. Maternal transfer of antibodies specific for avian influenza viruses in captive whooper swans (Cygnus cygnus). Comp Immunol Microbiol Infect Dis. 2021 Apr 2;76:1. Abstract
submitted by kickingbird at Apr, 12, 2021 from Comp Immunol Microbiol Infect Dis. 2021 Apr 2;76:1 (via https://www.sciencedirect.com/science/article/abs/pii/S01479)
The transfer of maternal antibodies to offspring can effectively protect against avian influenza virus (AIV) infection during early life in chickens and can prevent AIV spread by decreasing the overall ... Sempere Borau M, Stertz S. Entry of influenza A virus into host cells - recent progress and remaining challenges. Curr Opin Virol. 2021 Apr 7;48:23-29. Abstract
submitted by kickingbird at Apr, 12, 2021 from Curr Opin Virol. 2021 Apr 7;48:23-29 (via https://www.sciencedirect.com/science/article/pii/S187962572)
Influenza A viruses (IAV) are a major burden for human health and thus the topic of intense research efforts. The entry of IAV into host cells is of particular interest as early infection steps are the ... Zheng J, Wen L, Yen HL, Liu M, Liu Y, Teng O, Wu W. Phenotypic and functional characteristics of a novel influenza hemagglutinin-specific memory NK cell. J Virol. 2021 Apr 7:JVI.00165-21. Abstract
submitted by kickingbird at Apr, 9, 2021 from J Virol. 2021 Apr 7:JVI.00165-21 (via https://jvi.asm.org/content/early/2021/04/02/JVI.00165-21)
Immune memory represents the most efficient defense against invasion and transmission of infectious pathogens. In contrast to memory T and B cells, the roles of innate immunity in recall responses remain ... Hu Z, Zhao J, Shi L, Hu J, Hu S, Liu X. Identification of the dominant non-neutralizing epitope in the haemagglutinin of H7N9 avian influenza virus. Virus Res. 2021 Apr 2:198409. Abstract
submitted by kickingbird at Apr, 6, 2021 from Virus Res. 2021 Apr 2:198409 (via https://www.sciencedirect.com/science/article/abs/pii/S01681)
H7N9 avian influenza vaccines induce high levels of non-neutralizing (nonNeu) antibodies against the haemagglutinin (HA). However, the antigenic epitopes underlying this particular antibody response are ... 5328 items, 20/Page, Page[67/267][|<<] [|<] [61] [62] [63] [64] [65] [66] [67] [68] [69] [70] [>|] [>>|] |
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