Beale DJ, et al. Untargeted metabolomics analysis of the upper respiratory tract of ferrets following influenza A virus infection and oseltamivir treatment. Metabolomics. 2019 Mar 1;15(3):33. Abstract
submitted by kickingbird at Mar, 5, 2019 from Metabolomics. 2019 Mar 1;15(3):33 (via https://link.springer.com/article/10.1007%2Fs11306-019-1499-)
INTRODUCTION: Influenza is a highly contagious respiratory disease that causes high global morbidity and mortality each year. The dynamics of an influenza infection on the host metabolism, and how metabolism ...
Sisteré-Oró M, et al. Conserved HA-peptide NG34 formulated in pCMV-CTLA4-Ig reduces viral shedding in pigs after a heterosubtypic influenza virus SwH3N2 challenge. PLoS One. 2019 Mar 1;14(3):e0212431. Abstract
submitted by kickingbird at Mar, 4, 2019 from PLoS One. 2019 Mar 1;14(3):e0212431 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Swine influenza viruses (SIVs), the causal agents of swine influenza, are not only important to control due to the economic losses in the swine industry, but also can be pandemic pathogens. Vaccination ...
Umut Karakus, et al. MHC class II proteins mediate cross-species entry of bat influenza viruses. Nature 20 Feb, 2019. Abstract
submitted by kickingbird at Mar, 3, 2019 from Nature 20 Feb, 2019 (via https://www.nature.com/articles/s41586-019-0955-3)
Zoonotic influenza A viruses of avian origin can cause severe disease in individuals, or even global pandemics, and thus pose a threat to human populations. Waterfowl and shorebirds are believed to be ...
Lim KS, et al. Direct visualization of avian influenza H5N1 Hemagglutinin precursor and its conformational change by high-speed atomic force microscopy. Biochim Biophys Acta Gen Subj. 2019 Feb 27.. Abstract
submitted by kickingbird at Mar, 3, 2019 from Biochim Biophys Acta Gen Subj. 2019 Feb 27. (via https://www.sciencedirect.com/science/article/pii/S030441651)
BACKGROUND: Hemagglutinin (HA) of influenza A is one of the key virulence factors that mediates the release of viral components in host cells. HA is initially synthesized as a trimeric precursor (HA0) ...
Paulino J, Pang X, Hung I, Zhou HX, Cross TA. Influenza A M2 Channel Clustering at High Protein/Lipid Ratios: Viral Budding Implications. Biophys J. 2019 Feb 10. Abstract
submitted by kickingbird at Mar, 3, 2019 from Biophys J. 2019 Feb 10 (via https://www.cell.com/biophysj/fulltext/S0006-3495(19)30114-6)
Protein dynamics in crowded environments is important for understanding protein functions in vivo and is especially relevant for membrane proteins because of the roles of protein-protein interactions in ...
Lalueza A, et al. Influence of viral load in the outcome of hospitalized patients with influenza virus infection. Eur J Clin Microbiol Infect Dis. 2019 Feb 28.. Abstract
submitted by kickingbird at Mar, 3, 2019 from Eur J Clin Microbiol Infect Dis. 2019 Feb 28. (via https://link.springer.com/article/10.1007%2Fs10096-019-03514)
The role of viral load in the outcome of patients requiring hospital admission due to influenza is not well established. We aim to assess if there is an association between the viral load and the outcome ...
Shepardson K, et al. A Novel Role for PDZ-Binding Motif of Influenza A Virus Nonstructural Protein 1 in Regulation of Host Susceptibility to Postinfluenza Bacterial Superinfections. Viral Immunol. 2019 Mar 1.. Abstract
submitted by kickingbird at Mar, 3, 2019 from Viral Immunol. 2019 Mar 1. (via https://www.liebertpub.com/doi/10.1089/vim.2018.0118)
Influenza A viruses (IAVs) have multiple mechanisms for altering the host immune response to aid in virus survival and propagation. While both type I and II interferons (IFNs) have been associated with ...
Zeng H, et al. Tropism and Infectivity of a Seasonal A(H1N1) and a Highly Pathogenic Avian A(H5N1) Influenza Virus in Primary Differentiated Ferret Nasal Epithelial Cell Cultures. J Virol. 2019 Feb 27.. Abstract
submitted by kickingbird at Mar, 1, 2019 from J Virol. 2019 Feb 27. (via https://jvi.asm.org/content/early/2019/02/22/JVI.00080-19)
Ferrets represent an invaluable animal model to study influenza virus pathogenesis and transmission. To further characterize this model, we developed a differentiated primary ferret nasal epithelial cell ...
Tang YS, Lo CY, Mok CK, Chan PK, Shaw PC. The extended C-terminal region of influenza C nucleoprotein is important for nuclear import and RNP activity. J Virol. 2019 Feb 27. Abstract
submitted by kickingbird at Mar, 1, 2019 from J Virol. 2019 Feb 27 (via https://jvi.asm.org/content/early/2019/02/22/JVI.02048-18)
The influenza C virus (ICV) is a human pathogenic agent and the infections are frequently identified in children. Compared to influenza A and B viruses, the nucleoprotein of ICV (NPC) has an extended C-terminal ...
Lu Y, et al. In Vivo Characterization of Avian Influenza A (H5N1) and (H7N9) Viruses Isolated from Canadian Travelers. Viruses. 2019 Feb 23;11(2).. Abstract
submitted by kickingbird at Mar, 1, 2019 from Viruses. 2019 Feb 23;11(2). (via https://www.mdpi.com/1999-4915/11/2/193)
Highly pathogenic avian influenza (HPAI) H5N1 and low pathogenic avian influenza (LPAI) H7N9 viruses pose a severe threat to public health through zoonotic infection, causing severe respiratory disease ...
Blanco-Lobo P, Nogales A, Rodríguez L, etc al. Novel Approaches for The Development of Live Attenuated Influenza Vaccines. Viruses. 2019 Feb 22;11(2).. Abstract
submitted by kickingbird at Mar, 1, 2019 from Viruses. 2019 Feb 22;11(2). (via https://www.mdpi.com/1999-4915/11/2/190)
Influenza virus still represents a considerable threat to global public health, despite the advances in the development and wide use of influenza vaccines. Vaccination with traditional inactivate influenza ...
Corbett KS, et al. Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages. MBio. 2019 Feb 26;10(1).. Abstract
submitted by kickingbird at Feb, 28, 2019 from MBio. 2019 Feb 26;10(1). (via https://mbio.asm.org/content/10/1/e02810-18)
Influenza vaccines targeting the highly conserved stem of the hemagglutinin (HA) surface glycoprotein have the potential to protect against pandemic and drifted seasonal influenza viruses not covered by ...
Farsakoglu Y, et al. Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner. Cell Rep. 2019 Feb 26;26(9):2307-2315.e5. Abstract
submitted by kickingbird at Feb, 28, 2019 from Cell Rep. 2019 Feb 26;26(9):2307-2315.e5 (via https://www.cell.com/cell-reports/fulltext/S2211-1247(19)301)
The role of natural killer (NK) cells in the immune response against vaccines is not fully understood. Here, we examine the function of infiltrated NK cells in the initiation of the inflammatory response ...
Rich HE, et al. Interferon Lambda Inhibits Bacterial Uptake During Influenza Super-Infection. Infect Immun. 2019 Feb 25. Abstract
submitted by kickingbird at Feb, 27, 2019 from Infect Immun. 2019 Feb 25 (via https://iai.asm.org/content/early/2019/02/22/IAI.00114-19)
Influenza kills 30-40,000 people each year in the United States, and causes ten times as many hospitalizations. A common complication of influenza is bacterial super-infection, which exacerbates morbidity ...
Jorquera PA, et al. Insights into the antigenic advancement of influenza A(H3N2) viruses, 2011~2018. Sci Rep. 2019 Feb 25;9(1):2676.. Abstract
submitted by kickingbird at Feb, 27, 2019 from Sci Rep. 2019 Feb 25;9(1):2676. (via https://www.nature.com/articles/s41598-019-39276-1)
Influenza A(H3N2) viruses evade human immunity primarily by acquiring antigenic changes in the haemagglutinin (HA). HA receptor-binding features of contemporary A(H3N2) viruses hinder traditional antigenic ...
Holzer B, Martini V, Edmans M, Tchilian E. T and B Cell Immune Responses to Influenza Viruses in Pigs. Front Immunol. 2019 Feb 5;10:98.. Abstract
submitted by kickingbird at Feb, 27, 2019 from Front Immunol. 2019 Feb 5;10:98. (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0009)
Influenza viruses are an ongoing threat to humans and are endemic in pigs, causing considerable economic losses to farmers. Pigs are also a source of new viruses potentially capable of initiating human ...
McGee CE, et al. Influenza-Mediated Lung Infection Models. Methods Mol Biol. 2019;1960:191-205.. Abstract
submitted by kickingbird at Feb, 27, 2019 from Methods Mol Biol. 2019;1960:191-205. (via https://www.ncbi.nlm.nih.gov/pubmed/30798533)
Laboratory rodent influenza infection models have been and continue to be a critical tool for understanding virus-host interactions during infection. The incidence of seasonal influenza infections coupled ...
Rao GK, et al. In Vivo Assessment of Antibody-Dependent Enhancement of Influenza B Infection. Toxicol Sci. 2019 Feb 22.. Abstract
submitted by kickingbird at Feb, 24, 2019 from Toxicol Sci. 2019 Feb 22. (via https://academic.oup.com/toxsci/advance-article-abstract/doi)
A theoretical safety concern proposed in the influenza literature is that therapeutic anti-viral antibodies could have the potential for antibody-dependent enhancement (ADE) of infection and disease. ADE ...
Gooch KE, et al. Heterosubtypic cross-protection correlates with cross-reactive interferon-gamma-secreting lymphocytes in the ferret model of influenza. Sci Rep. 2019 Feb 22;9(1):2617. Abstract
submitted by kickingbird at Feb, 24, 2019 from Sci Rep. 2019 Feb 22;9(1):2617 (via https://www.nature.com/articles/s41598-019-38885-0)
An effective universal vaccine for influenza will likely need to induce virus-specific T-cells, which are the major mediator of heterosubtypic cross-protection between different subtypes of influenza A ...
Henry C, et al. Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals. Cell Host Microbe. 2019 Jan 24. Abstract
submitted by kickingbird at Feb, 24, 2019 from Cell Host Microbe. 2019 Jan 24 (via https://www.sciencedirect.com/science/article/pii/S193131281)
Influenza is a leading cause of death in the elderly, and the vaccine protects only a fraction of this population. A key aspect of antibody-mediated anti-influenza virus immunity is adaptation to antigenically ...
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