Arevalo CP, Le Sage V, Bolton MJ, et al. Original Antigenic Sin Priming of Influenza Virus Hemagglutinin Stalk Antibodies. Proc Natl Acad Sci U S A . 2020 Jul 6;201920321. Abstract
submitted by kickingbird at Jul, 8, 2020 from Proc Natl Acad Sci U S A . 2020 Jul 6;201920321 (via https://pubmed.ncbi.nlm.nih.gov/32631992/)
Immunity to influenza viruses can be long-lived, but reinfections with antigenically distinct viral strains and subtypes are common. Reinfections can boost antibody responses against viral strains first ...
Müller NF, Stolz U, Dudas G, Stadler T, Vaughan TG. Bayesian Inference of Reassortment Networks Reveals Fitness Benefits of Reassortment in Human Influenza Viruses. Proc Natl Acad Sci U S A. 2020;201918304. Abstract
submitted by kickingbird at Jul, 8, 2020 from Proc Natl Acad Sci U S A. 2020;201918304 (via https://pubmed.ncbi.nlm.nih.gov/32631984/)
Reassortment is an important source of genetic diversity in segmented viruses and is the main source of novel pathogenic influenza viruses. Despite this, studying the reassortment process has been constrained ...
Kim HM, Lee N, Kim MS, Kang C, Chung YS. Characterization of Neuraminidase Inhibitor-Resistant Influenza Virus Isolates From Immunocompromised Patients in the Republic of Korea. Virol J. 2020;17(1):94. Abstract
submitted by kickingbird at Jul, 8, 2020 from Virol J. 2020;17(1):94 (via https://pubmed.ncbi.nlm.nih.gov/32631440/)
Background: The emergence of influenza viruses resistant to anti-influenza drugs is a threat to global public health. The Korea Centers for Disease Control and Prevention operates the Korea Influenza and ...
Tsai SK, Shih CH, Chang HW, et al. Replication of a Dog-Origin H6N1 Influenza Virus in Cell Culture and Mice. Viruses. 2020;12(7):E704. Abstract
submitted by kickingbird at Jul, 8, 2020 from Viruses. 2020;12(7):E704 (via https://pubmed.ncbi.nlm.nih.gov/32629810/)
The world's first natural avian-origin H6N1 influenza A virus infection case in dogs was confirmed in Taiwan in 2014. The H6N1 virus in chickens has been endemic in Taiwan since 1972. Whether the dog H6N1 ...
Scolamacchia F, Mulatti P, Mazzucato M, et al. Different Environmental Gradients Associated to the Spatiotemporal and Genetic Pattern of the H5N8 Highly Pathogenic Avian Influenza Outbreaks in Poultry in Italy. Transbound Emerg Dis. 2020;10.1111/tbed.13661. Abstract
submitted by kickingbird at Jul, 3, 2020 from Transbound Emerg Dis. 2020;10.1111/tbed.13661 (via https://pubmed.ncbi.nlm.nih.gov/32613724/)
Comprehensive understanding of the patterns and drivers of avian influenza outbreaks is pivotal to inform surveillance systems and heighten nations' ability to quickly detect and respond to the emergence ...
Zeng Z, Yau LF, Lin Z, et al. Characterization and Evolutionary Analysis of a Novel H3N2 Influenza A Virus Glycosylation Motif in Southern China. Front Microbiol. 2020;11:1318. Abstract
submitted by kickingbird at Jul, 3, 2020 from Front Microbiol. 2020;11:1318 (via https://pubmed.ncbi.nlm.nih.gov/32612596/)
An influenza A (H3N2) virus epidemic occurred in China in 2017 and the causative strain failed to bind red blood cells (RBCs), which may affect receptor binding and antibody recognition. The objective ...
Belser JA, Sun X, Brock N, et al. Genetically and Antigenically Divergent Influenza A(H9N2) Viruses Exhibit Differential Replication and Transmission Phenotypes in Mammalian Models. J Virol. 2020;JVI.00451-20. Abstract
submitted by kickingbird at Jul, 3, 2020 from J Virol. 2020;JVI.00451-20 (via https://pubmed.ncbi.nlm.nih.gov/32611751/)
Low pathogenicity avian influenza A(H9N2) viruses, enzootic in poultry populations in Asia, are associated with fewer confirmed human infections but higher rates of seropositivity compared to A(H5) or ...
Zhang RH, Li PY, Xu MJ, et al. Molecular Characterization and Pathogenesis of H9N2 Avian Influenza Virus Isolated From a Racing Pigeon. Vet Microbiol. 2020;246:108747. Abstract
submitted by kickingbird at Jul, 2, 2020 from Vet Microbiol. 2020;246:108747 (via https://pubmed.ncbi.nlm.nih.gov/32605760/)
H9N2 avian influenza viruses (AIVs) can cross species barriers and expand from birds tomammals and humans. It usually leads to economic loss for breeding farms and poses a serious threat to human health.This ...
Chen Z, Wang Z, Zhao X, et al. Pathogenicity of Different H5N6 Highly Pathogenic Avian Influenza Virus Strains and Host Immune Responses in Chickens. Vet Microbiol. 2020;246:108745. Abstract
submitted by kickingbird at Jul, 2, 2020 from Vet Microbiol. 2020;246:108745 (via https://pubmed.ncbi.nlm.nih.gov/32605756/)
The H5N6 highly pathogenic avian influenza virus (HPAIV) has been circulating in China since 2013. In this report, we describe our recent chicken experimental studies investigating the pathogenicity and ...
Ruan BY, Yao Y, Wang SY, et al. Protective Efficacy of a Bivalent Inactivated Reassortant H1N1 Influenza Virus Vaccine Against European Avian-Like and Classical Swine Influenza H1N1 Viruses in Mice. Vet Microbiol. 2020;246:108724. Abstract
submitted by kickingbird at Jul, 2, 2020 from Vet Microbiol. 2020;246:108724 (via https://pubmed.ncbi.nlm.nih.gov/32605742/)
The classical swine (CS) H1N1 swine influenza virus (SIVs) emerged in humans as a reassortant virus that caused the H1N1 influenza virus pandemic in 2009, and the European avian-like (EA) H1N1 SIVs has ...
Dos Anjos Borges LG, Pisanelli G, Khatun O, García. Live Visualization of Hemagglutinin Dynamics During Infection by Using a Novel Reporter Influenza A Virus. Viruses. 2020;12(6):E687. Abstract
submitted by kickingbird at Jul, 2, 2020 from Viruses. 2020;12(6):E687 (via https://pubmed.ncbi.nlm.nih.gov/32604762/)
Live visualization of influenza A virus (IAV) structural proteins during viral infection in cells is highly sought objective to study different aspects of the viral replication cycle. To achieve this, ...
Hu M, Yang G, DeBeauchamp J, et al. HA Stabilization Promotes Replication and Transmission of Swine H1N1 Gamma Influenza Viruses in Ferrets. Elife. 2020;9:e56236.. Abstract
submitted by kickingbird at Jul, 2, 2020 from Elife. 2020;9:e56236. (via https://pubmed.ncbi.nlm.nih.gov/32602461/)
Pandemic influenza A viruses can emerge from swine, an intermediate host that supports adaptation of human-preferred receptor-binding specificity by the hemagglutinin (HA) surface antigen. Other HA traits ...
Hu Z, Shi L, Xu N, et al. Induction of Cross-Group Broadly Reactive Antibody Response by Natural H7N9 Avian Influenza Virus Infection and Immunization With Inactivated H7N9 Vaccine in Chickens. Transbound Emerg Dis. 2020;10.1111/tbed.13705. Abstract
submitted by kickingbird at Jul, 2, 2020 from Transbound Emerg Dis. 2020;10.1111/tbed.13705 (via https://pubmed.ncbi.nlm.nih.gov/32602258/)
Pre-existing immunity against the conserved hemagglutinin (HA) stalk underlies the elicitation of cross-group antibody induced by natural H7N9 virus infection and immunization in humans. However, whether ...
Park JK, Xiao Y, Ramuta MD, et al. Pre-existing Immunity to Influenza Virus Hemagglutinin Stalk Might Drive Selection for Antibody-Escape Mutant Viruses in a Human Challenge Model. Nat Med. 2020;10.1038/s41591-020-0937-x. Abstract
submitted by kickingbird at Jul, 2, 2020 from Nat Med. 2020;10.1038/s41591-020-0937-x (via https://pubmed.ncbi.nlm.nih.gov/32601336/)
The conserved region of influenza hemagglutinin (HA) stalk (or stem) has gained attention as a potent target for universal influenza vaccines1-5. Although the HA stalk region is relatively well conserved, ...
Le Sage V, Kanarek JP, Snyder DJ, Cooper VS, Lakda. Mapping of Influenza Virus RNA-RNA Interactions Reveals a Flexible Network. Cell Rep. 2020;31(13):107823. Abstract
submitted by kickingbird at Jul, 2, 2020 from Cell Rep. 2020;31(13):107823 (via https://pubmed.ncbi.nlm.nih.gov/32610124/)
Selective assembly of influenza virus segments into virions is proposed to be mediated through intersegmental RNA-RNA interactions. Here, we developed a method called 2CIMPL that includes proximity ligation ...
Ruan T, Sun J, Liu W, et al. H1N1 Influenza Virus Cross-Activates Gli1 to Disrupt the Intercellular Junctions of Alveolar Epithelial Cells. Cell Rep. 2020;31(13):107801. Abstract
submitted by kickingbird at Jul, 2, 2020 from Cell Rep. 2020;31(13):107801
Influenza A virus (IAV) primarily infects the airway and alveolar epithelial cells and disrupts the intercellular junctions, leading to increased paracellular permeability. Although this pathological change ...
Sevy AM, Gilchuk IM, Brown BP, et al. Computationally Designed Cyclic Peptides Derived From an Antibody Loop Increase Breadth of Binding for Influenza Variants. Structure. 2020;S0969-2126(20)30124-6. Abstract
submitted by kickingbird at Jul, 2, 2020 from Structure. 2020;S0969-2126(20)30124-6 (via https://pubmed.ncbi.nlm.nih.gov/32610044/)
The influenza hemagglutinin (HA) glycoprotein is the target of many broadly neutralizing antibodies. However, influenza viruses can rapidly escape antibody recognition by mutation of hypervariable regions ...
Jansen AJG, Spaan T, Low HZ, et al. Influenza-induced Thrombocytopenia Is Dependent on the Subtype and Sialoglycan Receptor and Increases With Virus Pathogenicity. Blood Adv. 2020;4(13):2967-2978. Abstract
submitted by kickingbird at Jul, 2, 2020 from Blood Adv. 2020;4(13):2967-2978 (via https://pubmed.ncbi.nlm.nih.gov/32609845/)
Thrombocytopenia is a common complication of influenza virus infection, and its severity predicts the clinical outcome of critically ill patients. The underlying cause(s) remain incompletely understood. ...
HL Sun, et al. Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection. PNAS first published June 29, 2020. Abstract
submitted by kickingbird at Jun, 30, 2020 from PNAS first published June 29, 2020 (via https://www.pnas.org/content/early/2020/06/23/1921186117)
Pigs are considered as important hosts or “mixing vessels” for the generation of pandemic influenza viruses. Systematic surveillance of influenza viruses in pigs is essential for early warning and preparedness ...
Zhu Y, Wang R, Yu L, et al. Human TRA2A Determines Influenza A Virus Host Adaptation by Regulating Viral mRNA Splicing. Sci Adv. 2020;6(25):eaaz5764. Abstract
submitted by kickingbird at Jun, 30, 2020 from Sci Adv. 2020;6(25):eaaz5764 (via https://pubmed.ncbi.nlm.nih.gov/32596447/)
Several avian influenza A viruses (IAVs) have adapted to mammalian species, including humans. To date, the mechanisms enabling these host shifts remain incompletely understood. Here, we show that a host ...
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