Lamichhane PP, Puthavathana P. PR8 virus harbouring H5N1 NS gene contributed for THP-1 cell tropism. Virusdisease. 2018 Dec;29(4):548-552.. Abstract
submitted by kickingbird at Dec, 14, 2018 from Virusdisease. 2018 Dec;29(4):548-552. (via https://www.ncbi.nlm.nih.gov/pubmed/30539061)
Innate immune cells are key player in immune response to influenza virus infection. Influenza infected monocytes exacerbate the disease pathology. However, monocytes differ in susceptibilities to influenza ...
Zhang K, et al. Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Proc Natl Acad Sci U S A. 2018 Dec 11. Abstract
submitted by kickingbird at Dec, 14, 2018 from Proc Natl Acad Sci U S A. 2018 Dec 11 (via https://www.ncbi.nlm.nih.gov/pubmed/30538201)
The influenza virulence factor NS1 protein interacts with the cellular NS1-BP protein to promote splicing and nuclear export of the viral M mRNAs. The viral M1 mRNA encodes the M1 matrix protein and is ...
Fike AJ, Kumova OK, Tardif VJ, Carey AJ. Neonatal influenza-specific effector CTLs retain elevated CD31 levels at the site of infection and have decreased IFN-γ production. J Leukoc Biol. 2018 Dec 11.. Abstract
submitted by kickingbird at Dec, 14, 2018 from J Leukoc Biol. 2018 Dec 11. (via https://www.ncbi.nlm.nih.gov/pubmed/30536476)
The underlying mechanisms that regulate neonatal immune suppression are poorly characterized. CD31 (PECAM1) is highly expressed on neonatal lymphocytes and is a known modulator of TCR signaling. To further ...
Lau H, Deng YM, Xu X, Sessions W, Barr IG. Rapid detection of new B/Victoria-lineage haemagglutinin variants of influenza B viruses by pyrosequencing. Diagn Microbiol Infect Dis. 2018 Nov 13.. Abstract
submitted by kickingbird at Dec, 13, 2018 from Diagn Microbiol Infect Dis. 2018 Nov 13. (via https://www.ncbi.nlm.nih.gov/pubmed/30528425)
During 2016/2017, several antigenically and genetically distinct variant viruses of the influenza B/Victoria/2/87-lineage (B/Vic) viruses, which have either deletions or mutations in the haemagglutinin ...
Radigan KA, et al. Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1. J Immunol. 2018 Dec 7.. Abstract
submitted by kickingbird at Dec, 13, 2018 from J Immunol. 2018 Dec 7. (via https://www.ncbi.nlm.nih.gov/pubmed/30530483)
Muscle dysfunction is common in patients with adult respiratory distress syndrome and is associated with morbidity that can persist for years after discharge. In a mouse model of severe influenza A pneumonia, ...
Zhang H, et al. Complete Genome Sequence of an Influenza C Virus Strain Identified from a Sick Calf in the United States. Microbiol Resour Announc. 2018 Jul 12;7(1).. Abstract
submitted by kickingbird at Dec, 13, 2018 from Microbiol Resour Announc. 2018 Jul 12;7(1). (via https://www.ncbi.nlm.nih.gov/pubmed/30533603)
Influenza C virus (ICV) has been identified for the first time from bovine respiratory disease complex (BRDC) samples in the United States. Here, we report the complete genome sequence of the strain C/bovine/Montana/12/2016, ...
Zeller MA, et al. Complete Genome Sequences of Two Novel Human-Like H3N2 Influenza A Viruses, A/swine/Oklahoma/65980/2017 (H3N2) and A/Swine/Oklahoma/65260/2017 (H3N2), Detected in Swine in the United States. Microbiol Resour Announc. 2018 Nov 21;7(20). Abstract
submitted by kickingbird at Dec, 13, 2018 from Microbiol Resour Announc. 2018 Nov 21;7(20) (via https://www.ncbi.nlm.nih.gov/pubmed/30533826)
Two novel human-like H3N2 influenza A virus strains, A/swine/Oklahoma/65980/2017 (H3N2) and A/swine/Oklahoma/65260/2017 (H3N2), were isolated from porcine samples submitted to the Iowa State University ...
Sangsiriwut K, et al. Complete Genomic Sequences of Highly Pathogenic H5N1 Avian Influenza Viruses Obtained Directly from Human Autopsy Specimens. Microbiol Resour Announc. 2018 Dec 6;7(22). Abstract
submitted by kickingbird at Dec, 13, 2018 from Microbiol Resour Announc. 2018 Dec 6;7(22) (via https://www.ncbi.nlm.nih.gov/pubmed/30533850)
The complete genomic sequences of H5N1 highly pathogenic avian influenza (HPAI) viruses were directly obtained from lung, trachea, and colon tissues and an intestinal fecal sample of a patient by using ...
Abdul-Cader MS, et al. Antiviral response elicited against avian influenza virus infection following activation of toll-like receptor (TLR)7 signaling pathway is attributable to interleukin (IL)-1β production. BMC Res Notes. 2018 Dec 4;11(1):859.. Abstract
submitted by kickingbird at Dec, 9, 2018 from BMC Res Notes. 2018 Dec 4;11(1):859. (via https://www.ncbi.nlm.nih.gov/pubmed/30514372)
OBJECTIVE: Single stranded ribonucleic acid (ssRNA) binds to toll-like receptor (TLR)7 leading to recruitment of immune cells and production of pro-inflammatory cytokines, which has been shown in mammals. ...
Vahey MD, Fletcher DA. Low-Fidelity Assembly of Influenza A Virus Promotes Escape from Host Cells. Cell. 2018 Nov 27. Abstract
submitted by kickingbird at Dec, 9, 2018 from Cell. 2018 Nov 27 (via https://www.ncbi.nlm.nih.gov/pubmed/30503209)
Influenza viruses inhabit a wide range of host environments using a limited repertoire of protein components. Unlike viruses with stereotyped shapes, influenza produces virions with significant morphological ...
Zhang X, et al. Tissue tropisms opt for transmissible reassortants during avian and swine influenza A virus co-infection in swine. PLoS Pathog. 2018 Dec 3;14(12). Abstract
submitted by kickingbird at Dec, 9, 2018 from PLoS Pathog. 2018 Dec 3;14(12) (via https://www.ncbi.nlm.nih.gov/pubmed/30507946)
Genetic reassortment between influenza A viruses (IAVs) facilitate emergence of pandemic strains, and swine are proposed as a "mixing vessel" for generating reassortants of avian and mammalian IAVs that ...
Tan KS, et al. Comparative Transcriptomic and Metagenomic Analyses of Influenza Virus-Infected Nasal Epithelial Cells From Multiple Individuals Reveal Specific Nasal-Initiated Signatures. Front Microbiol. 2018 Nov 14;9:2685. Abstract
submitted by kickingbird at Dec, 6, 2018 from Front Microbiol. 2018 Nov 14;9:2685 (via https://www.ncbi.nlm.nih.gov/pubmed/30487780)
In vitro and in vivo research based on cell lines and animals are likely to be insufficient in elucidating authentic biological and physiological phenomena mimicking human systems, especially for generating ...
Long JS, Mistry B, Haslam SM, Barclay WS. Host and viral determinants of influenza A virus species specificity. Nat Rev Microbiol. 2018 Nov 28. Abstract
submitted by kickingbird at Dec, 6, 2018 from Nat Rev Microbiol. 2018 Nov 28 (via https://www.nature.com/articles/s41579-018-0115-z)
Influenza A viruses cause pandemics when they cross between species and an antigenically novel virus acquires the ability to infect and transmit between these new hosts. The timing of pandemics is currently ...
?van?arová P, Betáková T. Conserved methionine 165 of matrix protein contributes to the nuclear import and is essential for influenza A virus replication. Virol J. 2018 Dec 3;15(1):187. Abstract
submitted by kickingbird at Dec, 6, 2018 from Virol J. 2018 Dec 3;15(1):187 (via https://www.ncbi.nlm.nih.gov/pubmed/30509291)
BACKGROUND: The influenza matrix protein (M1) layer under the viral membrane plays multiple roles in virus assembly and infection. N-domain and C-domain are connected by a loop region, which consists of ...
Ampomah PB, et al. Annexins in Influenza Virus Replication and Pathogenesis. Front Pharmacol. 2018 Nov 15;9:1282. Abstract
submitted by kickingbird at Dec, 6, 2018 from Front Pharmacol. 2018 Nov 15;9:1282 (via https://www.ncbi.nlm.nih.gov/pubmed/30498445)
Influenza A viruses (IAVs) are important human respiratory pathogens which cause seasonal or periodic endemic infections. IAV can result in severe or fatal clinical complications including pneumonia and ...
Zhou J, et al. Identification and characterization of GLDC as host susceptibility gene to severe influenza. EMBO Mol Med. 2018 Nov 28.. Abstract
submitted by kickingbird at Dec, 4, 2018 from EMBO Mol Med. 2018 Nov 28. (via https://www.ncbi.nlm.nih.gov/pubmed/30498026)
Glycine decarboxylase (GLDC) was prioritized as a candidate susceptibility gene to severe influenza in humans. The higher expression of GLDC derived from genetic variations may confer a higher risk to ...
Boyle CC, et al. Inflammation and dimensions of reward processing following exposure to the influenza vaccine. Psychoneuroendocrinology. 2018 Nov 20;102:16-23.. Abstract
submitted by kickingbird at Dec, 4, 2018 from Psychoneuroendocrinology. 2018 Nov 20;102:16-23. (via https://www.ncbi.nlm.nih.gov/pubmed/30496908)
BACKGROUND: Alterations in reward processing are a central feature of depression and may be influenced by inflammation. Indeed, inflammation is associated with deficits in reward-related processes in animal ...
Chaimayo C, et al. Specificity and functional interplay between influenza virus PA-X and NS1 shutoff activity. PLoS Pathog. 2018 Nov 29;14(11):e1007465. Abstract
submitted by kickingbird at Dec, 4, 2018 from PLoS Pathog. 2018 Nov 29;14(11):e1007465 (via https://www.ncbi.nlm.nih.gov/pubmed/30496325)
Influenza A viruses modulate host antiviral responses to promote viral growth and pathogenicity. Through viral PA-X and NS1 proteins, the virus is capable of suppressing host protein synthesis, termed ...
Oladipo EK, Oloke JK, Adeniji JA. Intravenous pathogenicity of influenza virus A/H5N1/2014 isolated from pig in Ogbomoso, Nigeria. Open Vet J. 2018;8(3):347-350.. Abstract
submitted by kickingbird at Dec, 4, 2018 from Open Vet J. 2018;8(3):347-350. (via https://www.ncbi.nlm.nih.gov/pubmed/30483460)
Understanding the pathogenicity of avian influenza viruses in poultry is an important scientific and public health challenge because of antigenic shift/drift and a source of novel, potentially human-pathogenic ...
Imai K, et al. Whole Genome Sequencing of Influenza A and B Viruses With the MinION Sequencer in the Clinical Setting: A Pilot Study. Front Microbiol. 2018 Nov 13;9:2748.. Abstract
submitted by kickingbird at Dec, 4, 2018 from Front Microbiol. 2018 Nov 13;9:2748. (via https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243006/)
Introduction: Whole genome sequencing (WGS) of influenza viruses is important for preparing vaccines and coping with newly emerging viruses. However, WGS is difficult to perform using conventional next-generation ...
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