Walker AP, Sharps J, Fodor E. Mutation of an influenza virus polymerase 3´ RNA promoter binding site inhibits transcription elongation. J Virol. 2020 Apr 15. pii: JVI.00498-20.. Abstract
submitted by kickingbird at Apr, 18, 2020 from J Virol. 2020 Apr 15. pii: JVI.00498-20. (via https://jvi.asm.org/content/early/2020/04/09/JVI.00498-20)
Influenza A virus encodes a viral RNA-dependent RNA polymerase (FluPolA), which is responsible for transcribing and replicating the negative-sense viral RNA (vRNA) genome. FluPolA transcribes vRNA using ...
Li Y, et al. Characteristics of the first H16N3 subtype influenza A viruses isolated in western China.. Transbound Emerg Dis. 2020 Apr 7. Abstract
submitted by kickingbird at Apr, 12, 2020 from Transbound Emerg Dis. 2020 Apr 7 (via https://www.ncbi.nlm.nih.gov/pubmed/32266788)
The first documented avian influenza virus subtype H16N3 was isolated in 1975 and is currently detectable in many countries worldwide. However, the prevalence, biological characteristics and threat to ...
Wangchareansak T, et al. Influenza A virus molecularly imprinted polymers and their application in virus sub-type classification. J Mater Chem B. 2013 Apr 28;1(16):2190-2197. Abstract
submitted by kickingbird at Apr, 12, 2020 from J Mater Chem B. 2013 Apr 28;1(16):2190-2197 (via https://pubs.rsc.org/en/content/articlelanding/2013/TB/c3tb0)
In this work, we apply a molecular imprinting strategy as a screening protocol for different influenza A subtypes, namely H5N1, H5N3, H1N1, H1N3 and H6N1. Molecularly imprinted polymers for each of these ...
Wu XX, et al. Novel pathogenic characteristics of highly pathogenic avian influenza virus H7N9: viraemia and extrapulmonary infection. Emerg Microbes Infect. 2020 Apr 8:1-39. Abstract
submitted by kickingbird at Apr, 12, 2020 from Emerg Microbes Infect. 2020 Apr 8:1-39 (via https://www.ncbi.nlm.nih.gov/pubmed/32267217)
The H7N9 virus mutated in 2017, resulting in new cases of highly pathogenic avian influenza (HPAI) H7N9 virus infection. H7N9 was found in a viraemic patient in Guangdong province, China. The present study ...
Okuya K, et al. A potential role of non-neutralizing IgA antibodies in cross-protective immunity against influenza A viruses of multiple hemagglutinin subtypes. J Virol. 2020 Apr 8. Abstract
submitted by kickingbird at Apr, 12, 2020 from J Virol. 2020 Apr 8 (via https://jvi.asm.org/content/early/2020/04/02/JVI.00408-20)
IgA antibodies on mucosal surfaces are known to play an important role in protection from influenza A virus (IAV) infection and are believed to be more potent than IgG for cross-protective immunity against ...
Peacock TP, et al. Swine ANP32A supports avian influenza virus polymerase. J Virol. 2020 Apr 8.. Abstract
submitted by kickingbird at Apr, 12, 2020 from J Virol. 2020 Apr 8. (via https://jvi.asm.org/content/early/2020/04/02/JVI.00132-20)
Avian influenza viruses occasionally infect and adapt to mammals, including humans. Swine are often described as 'mixing vessels', being susceptible to both avian and human origin viruses, which allows ...
Parvin R, et al. Active virological surveillance in backyard ducks in Bangladesh: Detection of avian influenza and gamma-coronaviruses. Avian Pathol. 2020 Apr 9:1-29.. Abstract
submitted by kickingbird at Apr, 12, 2020 from Avian Pathol. 2020 Apr 9:1-29. (via https://www.ncbi.nlm.nih.gov/pubmed/32271094)
Domestic waterfowl plays an important role in the perpetuation and transmission of avian pathogens including avian influenza viruses (AIV) of low and high pathogenicity, which pose severe economic and ...
Suzuki S, et al. Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza A virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution. Antiviral Res. 2020 Apr 6:104790. Abstract
submitted by kickingbird at Apr, 12, 2020 from Antiviral Res. 2020 Apr 6:104790 (via https://www.ncbi.nlm.nih.gov/pubmed/32272175)
Human cases of H7N9 influenza A virus infection have been increasing since 2013. The first choice of treatment for influenza is neuraminidase (NA) inhibitors (NAIs), but there is a concern that NAI-resistant ...
Xiao Y, et al. Influenza PB1-F2 Inhibits Avian MAVS Signaling. Viruses. 2020 Apr 7;12(4). Abstract
submitted by kickingbird at Apr, 12, 2020 from Viruses. 2020 Apr 7;12(4) (via https://www.mdpi.com/1999-4915/12/4/409)
RIG-I plays an essential role in the duck innate immune response to influenza infection. RIG-I engages the critical adaptor protein mitochondrial antiviral signaling (MAVS) to activate the downstream signaling ...
Poursiami M, Moazen S, Nejatollahi F, Moatari A. Isolation of Neutralizing Human Single Chain Antibodies Against Conserved Hemagglutinin Epitopes of Influenza a Virus H3N2 Strain. Rep Biochem Mol Biol. 2019 Oct;8(3):301-309.. Abstract
submitted by kickingbird at Apr, 12, 2020 from Rep Biochem Mol Biol. 2019 Oct;8(3):301-309. (via https://www.ncbi.nlm.nih.gov/pubmed/32274402)
Background: Immunotherapies using monoclonal antibodies against influenza A hemagglutinin (HA) has been an effective means for controlling Influenza spread. An alternative method for viral prophylaxis ...
Nyang´au EM, Bulimo WD, Mobegi V, Opanda S,. Genetic Analysis of HA1 Domain of Influenza A/H3N2 Viruses Isolated in Kenya During the 2007 to 2013 Seasons Reveal Significant Divergence from WHO-Recommended Vaccine Strains. Int J Infect Dis. 2020 Apr 7.. Abstract
submitted by kickingbird at Apr, 12, 2020 from Int J Infect Dis. 2020 Apr 7. (via https://www.ncbi.nlm.nih.gov/pubmed/32276045)
BACKGROUND: Influenza viruses evolve rapidly and cause regular seasonal epidemics in humans challenging effective vaccination. The virus surface HA glycoprotein is the primary target for the host immune ...
Lee CY, An SH, Choi JG, Lee YJ, Kim JH, Kwon HJ. Rank orders of mammalian pathogenicity-related PB2 mutations of avian influenza A viruses. Sci Rep. 2020 Mar 24;10(1):5359.. Abstract
submitted by kickingbird at Mar, 31, 2020 from Sci Rep. 2020 Mar 24;10(1):5359. (via https://www.ncbi.nlm.nih.gov/pubmed/32210274)
The PB2 gene is one of the key determinants for the mammalian adaptation of avian influenza A viruses (IAVs). Although mammalian pathogenicity-related mutations (MPMs) in PB2 genes were identified in different ...
Jia N, et al. The Human Lung Glycome Reveals Novel Glycan Ligands for Influenza A Virus. Sci Rep. 2020 Mar 24;10(1):5320. Abstract
submitted by kickingbird at Mar, 31, 2020 from Sci Rep. 2020 Mar 24;10(1):5320 (via https://www.ncbi.nlm.nih.gov/pubmed/32210305)
Glycans within human lungs are recognized by many pathogens such as influenza A virus (IAV), yet little is known about their structures. Here we present the first analysis of the N- and O- and glycosphingolipid-glycans ...
Venkatesh D, et al. Detection of H3N8 influenza A virus with multiple mammalian-adaptive mutations in a rescued Grey seal (Halichoerus grypus) pup. Virus Evol. 2020 Mar 18;6(1):veaa016.. Abstract
submitted by kickingbird at Mar, 31, 2020 from Virus Evol. 2020 Mar 18;6(1):veaa016. (via https://academic.oup.com/ve/article/6/1/veaa016/5809603)
Avian influenza A viruses (IAVs) in different species of seals display a spectrum of pathogenicity, from sub-clinical infection to mass mortality events. Here we present an investigation of avian IAV infection ...
Yang F, et al. Generation of neutralizing and non-neutralizing monoclonal antibodies against H7N9 influenza virus. Emerg Microbes Infect. 2020 Mar 20;9(1):664-675.. Abstract
submitted by kickingbird at Mar, 24, 2020 from Emerg Microbes Infect. 2020 Mar 20;9(1):664-675. (via https://www.ncbi.nlm.nih.gov/pubmed/32193996)
The H7N9 viruses have been circulating for six years. The insertion of a polybasic cleavage site in the haemagglutinin (HA) protein of H7N9 has resulted in the emergence of a highly pathogenic (HP) avian ...
Wu H, Liu F, Yang F, Xiao Y, Yao H, Wu N. Amino acid substitutions involved in the adaptation of a novel H7N7 avian influenza virus in mice. Res Vet Sci. 2020 Mar 10;130:203-206.. Abstract
submitted by kickingbird at Mar, 24, 2020 from Res Vet Sci. 2020 Mar 10;130:203-206. (via https://www.ncbi.nlm.nih.gov/pubmed/32200160)
The H7N7 avian influenza viruses can infect humans and poses a great threat to human health. To identify the amino acid substitutions that are associated with adaptation of avian-origin H7N7 virus to mammals, ...
Zhang T, et al. Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis. Cell. 2020 Mar 19;180(6):1115-1129.e13.. Abstract
submitted by kickingbird at Mar, 24, 2020 from Cell. 2020 Mar 19;180(6):1115-1129.e13. (via https://www.ncbi.nlm.nih.gov/pubmed/32200799)
Influenza A virus (IAV) is a lytic RNA virus that triggers receptor-interacting serine/threonine-protein kinase 3 (RIPK3)-mediated pathways of apoptosis and mixed lineage kinase domain-like pseudokinase ...
Shiu EYC, et al. Frequent recovery of influenza A but not influenza B virus RNA in aerosols in pediatric patient rooms. Indoor Air. 2020 Mar 23.. Abstract
submitted by kickingbird at Mar, 24, 2020 from Indoor Air. 2020 Mar 23. (via https://www.ncbi.nlm.nih.gov/pubmed/32201989)
Influenza transmission occurs through the air, but the relative importance of small droplets, or aerosols, in influenza transmission especially within healthcare facilities remains uncertain. Detections ...
Cho JH, et al. Molecular recognition of a host protein by NS1 of pandemic and seasonal influenza A viruses. Proc Natl Acad Sci U S A. 2020 Mar 9. Abstract
submitted by kickingbird at Mar, 11, 2020 from Proc Natl Acad Sci U S A. 2020 Mar 9 (via https://www.pnas.org/content/early/2020/03/06/1920582117)
The 1918 influenza A virus (IAV) caused the most severe flu pandemic in recorded human history. Nonstructural protein 1 (NS1) is an important virulence factor of the 1918 IAV. NS1 antagonizes host defense ...
Li X, Zhang L, Liu Y, Ma L, Zhang N, Xia C. Structures of the MHC-I molecule BF2*1501 disclose the preferred presentation of an H5N1 virus-derived epitope. J Biol Chem. 2020 Mar 9.. Abstract
submitted by kickingbird at Mar, 11, 2020 from J Biol Chem. 2020 Mar 9. (via https://www.ncbi.nlm.nih.gov/pubmed/32152225)
Lethal infections by strains of the highly pathogenic avian influenza virus (HPAIV) H5N1 pose serious threats to both the poultry industry and public health worldwide. A lack of confirmed HPAIV epitopes ...
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