Mine J, et al. Phylogeographic evidence for the inter-and intracontinental dissemination of avian influenza viruses via migration flyways. PLoS One. 2019 Jun 26;14(6):e0218506.. Abstract
submitted by kickingbird at Jun, 28, 2019 from PLoS One. 2019 Jun 26;14(6):e0218506. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Genetically related highly pathogenic avian influenza viruses (HPAIVs) of H5N6 subtype caused outbreaks simultaneously in East Asia and Europe-geographically distinct regions-during winter 2017-2018. This ...
Zhuang Q, et al. Diversity and distribution of type A influenza viruses: an updated panorama analysis based on protein sequences. Virol J. 2019 Jun 26;16(1):85. Abstract
submitted by kickingbird at Jun, 28, 2019 from Virol J. 2019 Jun 26;16(1):85 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
BACKGROUND: Type A influenza viruses (IAVs) cause significant infections in humans and multiple species of animals including pigs, horses, birds, dogs and some marine animals. They are of complicated phylogenetic ...
Leach S, et al. Requirement for memory B cell activation in protection from heterologous influenza virus reinfection. Int Immunol. 2019 Jun 20.. Abstract
submitted by kickingbird at Jun, 25, 2019 from Int Immunol. 2019 Jun 20. (via https://academic.oup.com/intimm/advance-article-abstract/doi)
While two memory compartments, memory B cells and long-lived plasma cells, are thought to contribute to the successful establishment of memory recall responses, the unique roles of each cellular compartment ...
Yan HX, Xu HF, He WJ, Xie Y, Dong GY.. Phylogenetic analysis of HA and NA genes of influenza H1N1 viruses from 1918 to 2017. Acta Virol. 2019;63(2):195-202.. Abstract
submitted by kickingbird at Jun, 25, 2019 from Acta Virol. 2019;63(2):195-202. (via https://www.ncbi.nlm.nih.gov/pubmed/31230448)
The 1918 "Spanish" pandemic is the earliest known influenza H1N1 virus. Since then H1N1 viruses circulated between humans and animals continuously. With the increased amount of samples of H1N1 viruses ...
Ma MJ, et al. Characterization of antibody and memory T cell response in H7N9 survivors: A cross-sectional analysis. Clin Microbiol Infect. 2019 Jun 20. Abstract
submitted by kickingbird at Jun, 25, 2019 from Clin Microbiol Infect. 2019 Jun 20 (via https://www.clinicalmicrobiologyandinfection.com/article/S11)
OBJECTIVES: Despite the importance of immunological memory for protective immunity against viral infection, whether H7N9-specific antibodies and memory T-cell responses remain detectable years after the ...
Adams SE, et al. Effect of influenza H1N1 neuraminidase V116A and I117V mutations on NA activity and sensitivity to NA inhibitors. Antiviral Res. 2019 Jun 19:104539.. Abstract
submitted by kickingbird at Jun, 24, 2019 from Antiviral Res. 2019 Jun 19:104539. (via https://www.sciencedirect.com/science/article/pii/S016635421)
Neuraminidase inhibitors (NAIs) play a key role in the management of influenza. Given the limited number of FDA-approved anti-influenza drugs, evaluation of potential drug-resistant variants is of high ...
Nemoto M, et al. A single amino acid change in hemagglutinin reduces the cross-reactivity of antiserum against an equine influenza vaccine strain. Arch Virol. 2019 Jun 21.. Abstract
submitted by kickingbird at Jun, 24, 2019 from Arch Virol. 2019 Jun 21. (via https://link.springer.com/article/10.1007%2Fs00705-019-04328)
Equine influenza virus is an important pathogen for the horse industry because of its economic impact, and vaccination is a key control measure. Our previous work suggested that a mutation at position ...
Prier JE, et al. Early T-BET Expression Ensures an Appropriate CD8+ Lineage-Specific Transcriptional Landscape after Influenza A Virus Infection. J Immunol. 2019 Jun 21.. Abstract
submitted by kickingbird at Jun, 24, 2019 from J Immunol. 2019 Jun 21. (via https://www.jimmunol.org/content/early/2019/06/21/jimmunol.1)
Virus infection triggers large-scale changes in the phenotype and function of naive CD8+ T cells, resulting in the generation of effector and memory T cells that are then critical for immune clearance. ...
Xiao Y, et al. Deep sequencing of 2009 influenza A/H1N1 virus isolated from volunteer human challenge study participants and natural infections. Virology. 2019 Jun 13;534:96-107.. Abstract
submitted by kickingbird at Jun, 23, 2019 from Virology. 2019 Jun 13;534:96-107. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Nasal wash samples from 15 human volunteers challenged with GMP manufactured influenza A/California/04/2009(H1N1) and from 5 naturally infected influenza patients of the 2009 pandemic were deep sequenced ...
Nichols JE, Niles JA, Fleming EH, Roberts NJ. The role of cell surface expression of influenza virus neuraminidase in induction of human lymphocyte apoptosis. Virology. 2019 Jun 10;534:80-86.. Abstract
submitted by kickingbird at Jun, 21, 2019 from Virology. 2019 Jun 10;534:80-86. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
The immunopathological mechanisms as well as the role played by influenza A virus infection of human leukocytes and induction of apoptosis have not been fully elucidated. We confirm here that the percentage ...
Liu JH, Chang CC, Chen CW, Wong LT, Chu YW. Conservation Region Finding for Influenza A Viruses by Machine Learning methods of N-linked Glycosylation Sites and B-cell Epitopes. Math Biosci. 2019 Jun 17:108217. Abstract
submitted by kickingbird at Jun, 21, 2019 from Math Biosci. 2019 Jun 17:108217 (via https://www.sciencedirect.com/science/article/abs/pii/S00255)
Influenza type A, a serious infectious disease of the human respiratory tract, poses an enormous threat to human health worldwide. It leads to high mortality rates in poultry, pigs, and humans. The primary ...
Li X, Xu B, Shaman J. Pathobiological features favouring the intercontinental dissemination of highly pathogenic avian influenza virus. R Soc Open Sci. 2019 May 8;6(5):190276. Abstract
submitted by kickingbird at Jun, 21, 2019 from R Soc Open Sci. 2019 May 8;6(5):190276 (via https://royalsocietypublishing.org/doi/10.1098/rsos.190276)
Avian influenza viruses (AIVs) are a continued threat to global health and economy. Unlike other highly pathogenic AIVs, novel H5N8 disseminated very quickly from Korea to other areas in Asia, Europe and ...
Spencer S, Thompson MG, Flannery B, Fry A. Comparison of Respiratory Specimen Collection Methods for Detection of Influenza Virus Infection by RT-PCR: A Literature Review. J Clin Microbiol. 2019 Jun 19.. Abstract
submitted by kickingbird at Jun, 21, 2019 from J Clin Microbiol. 2019 Jun 19. (via https://jcm.asm.org/content/early/2019/06/17/JCM.00027-19)
Detection of influenza virus in respiratory specimens from ill individuals is the most commonly used method to identify influenza virus infection. A number of respiratory specimen types may be used, including ...
Staller E, et al. ANP32 proteins are essential for influenza virus replication in human cells. J Virol. 2019 Jun 19.. Abstract
submitted by kickingbird at Jun, 21, 2019 from J Virol. 2019 Jun 19. (via https://jvi.asm.org/content/early/2019/06/13/JVI.00217-19)
ANP32 proteins have been implicated in supporting influenza virus replication, but most of the work to date has focused on the ability of avian Anp32 proteins to overcome restriction of avian influenza ...
Lim HK, et al. Severe influenza pneumonitis in children with inherited TLR3 deficiency. J Exp Med. 2019 Jun 19.. Abstract
submitted by kickingbird at Jun, 21, 2019 from J Exp Med. 2019 Jun 19. (via http://jem.rupress.org/content/early/2019/06/18/jem.20181621)
Autosomal recessive IRF7 and IRF9 deficiencies impair type I and III IFN immunity and underlie severe influenza pneumonitis. We report three unrelated children with influenza A virus (IAV) infection manifesting ...
Peng Q, et al. Structural insight into RNA synthesis by influenza D polymerase. Nat Microbiol. 2019 Jun 17. Abstract
submitted by kickingbird at Jun, 19, 2019 from Nat Microbiol. 2019 Jun 17 (via https://www.nature.com/articles/s41564-019-0487-5)
The influenza virus polymerase uses capped RNA primers to initiate transcription, and a combination of terminal and internal de novo initiations for the two-step replication process by binding the conserved ...
Libin Liang, et al. Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals. mBio. Abstract
submitted by kickingbird at Jun, 19, 2019 from mBio (via https://mbio.asm.org/content/10/3/e01162-19)
Avian influenza viruses (AIVs) must acquire mammalian-adaptive mutations before they can efficiently replicate in and transmit among humans. The PB2 E627K mutation is known to play a prominent role in ...
Gao L, et al. Integration analysis of a miRNA-mRNA expression in A549 cells infected with a novel H3N2 swine influenza virus and the 2009 H1N1 pandemic influenza virus. Infect Genet Evol. 2019 Jun 14:103922. Abstract
submitted by kickingbird at Jun, 18, 2019 from Infect Genet Evol. 2019 Jun 14:103922 (via https://www.ncbi.nlm.nih.gov/pubmed/31207403)
Swine are reservoirs for anthropogenic/zoonotic influenza viruses, and the prevalence and repeated introduction of the 2009 H1N1 pandemic influenza virus (pdm/09) into pigs raises the possibility of generating ...
Andreychuk DB, et al. Armored Exogenous Internal Control for Real-Time PCR Diagnosis of Avian Influenza. Avian Pathol. 2019 Jun 17:1-15.. Abstract
submitted by kickingbird at Jun, 18, 2019 from Avian Pathol. 2019 Jun 17:1-15. (via https://www.tandfonline.com/doi/abs/10.1080/03079457.2019.16)
An exogenous "armored" PCR internal control (IC) short RNA was analyzed in conjunction with real-time RT-PCR method for diagnosis of avian influenza. The resistance to nucleases and increase the physical ...
Wu H, Yang F, Xiao Y, Liu F, Yao H, Wu N. Adaptive amino acid substitutions enhance the virulence of an avian-origin H6N1 influenza virus in mice. Infect Genet Evol. 2019 Jun 11:103918. Abstract
submitted by kickingbird at Jun, 16, 2019 from Infect Genet Evol. 2019 Jun 11:103918 (via https://www.sciencedirect.com/science/article/pii/S156713481)
The H6N1 subtype avian influenza virus (AIV) is a zoonotic infectious disease pathogen, which poses a threat to human health. In order to study the possible substitution of H6N1 AIV for mammals, an avian-origin ...
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