Beigel JH. Polyclonal and monoclonal antibodies for the treatment of influenza. Curr Opin Infect Dis. 2018 Oct 5.. Abstract
submitted by kickingbird at Oct, 15, 2018 from Curr Opin Infect Dis. 2018 Oct 5. (via https://www.ncbi.nlm.nih.gov/pubmed/30299360)
PURPOSE OF REVIEW: This review summarizes past and ongoing efforts for using polyclonal and monoclonal antibodies for the treatment of influenza, and is focused on products that have entered clinical trials.RECENT ... Vanderbeke L, et al. Invasive pulmonary aspergillosis complicating severe influenza: epidemiology, diagnosis and treatment. Curr Opin Infect Dis. 2018 Oct 5. Abstract
submitted by kickingbird at Oct, 15, 2018 from Curr Opin Infect Dis. 2018 Oct 5 (via https://www.ncbi.nlm.nih.gov/pubmed/30299367)
PURPOSE OF REVIEW: Bacterial superinfection of critically ill influenza patients is well-known, but in recent years, more and more reports describe invasive aspergillosis as a frequent complication as ... Li J, et al.. Continued reassortment of avian H6 influenza viruses from Southern China, 2014~2016. Transbound Emerg Dis. 2018 Oct 9.. Abstract
submitted by kickingbird at Oct, 15, 2018 from Transbound Emerg Dis. 2018 Oct 9. (via https://www.ncbi.nlm.nih.gov/pubmed/30300968)
H6 subtype avian influenza virus (AIV) was prevalent in poultry and could sporadically infect humans. Here, a total of 196 novel H6 AIVs isolated from poultry in eight provinces of China from 2014 to 2016 ... Khurana S, et al. AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization. NPJ Vaccines. 2018 Oct 1;3:40.. Abstract
submitted by kickingbird at Oct, 15, 2018 from NPJ Vaccines. 2018 Oct 1;3:40. (via https://www.ncbi.nlm.nih.gov/pubmed/30302282)
Immune responses to inactivated vaccines against avian influenza are poor due in part to lack of immune memory. Adjuvants significantly increased virus neutralizing titers. We performed comprehensive analyses ... Li R, et al.. Tree shrew as a new animal model to study the pathogenesis of avian influenza (H9N2) virus infection. Emerg Microbes Infect. 2018 Oct 10;7(1):166.. Abstract
submitted by kickingbird at Oct, 15, 2018 from Emerg Microbes Infect. 2018 Oct 10;7(1):166. (via https://www.ncbi.nlm.nih.gov/pubmed/30301950)
Outbreaks of avian influenza virus continue to pose threats to human health. Animal models such as the mouse, ferret, and macaque are used to understand the pathogenesis of avian influenza virus infection ... Van Hemert C, et., al. Survey of Arctic Alaskan Wildlife For Influenza A Antibodies: Limited Evidence For Exposure of Mammals. J Wildl Dis. 2018 Oct 5.. Abstract
submitted by kickingbird at Oct, 11, 2018 from J Wildl Dis. 2018 Oct 5. (via https://www.ncbi.nlm.nih.gov/pubmed/30289331)
Influenza A viruses (IAVs) are maintained in wild waterbirds and have the potential to infect a broad range of species, including wild mammals. The Arctic Coastal Plain of Alaska supports a diverse suite ... Hagan RS, Torres-Castillo J, Doerschuk CM. Myeloid TBK1 Signaling Contributes to the Immune Response to Influenza. Am J Respir Cell Mol Biol. 2018 Oct 5.. Abstract
submitted by kickingbird at Oct, 11, 2018 from Am J Respir Cell Mol Biol. 2018 Oct 5. (via https://www.ncbi.nlm.nih.gov/pubmed/30290124)
Macrophages provide key elements of the host response to influenza A virus (IAV) infection, including expression of type I interferon (IFN) and inflammatory cytokines and chemokines. TANK-binding kinase ... Lee MS, Jang EY, Cho J, Kim K, Lee CH. Development and comparison of two H5N8 influenza A vaccine candidate strains. Arch Virol. 2018 Oct 5.. Abstract
submitted by kickingbird at Oct, 11, 2018 from Arch Virol. 2018 Oct 5. (via https://www.ncbi.nlm.nih.gov/pubmed/30291503)
Avian influenza viruses circulating in birds have caused outbreaks of infection in poultry and humans, thereby threatening public health. Recently, a highly pathogenic avian influenza (HPAI) virus (H5N8) ... Yu Z, Gao Y, He H, Zhao Y, Yuan X, Cheng K. Isolation and genetic characterization of H13N8 low pathogenic avian influenza virus from migratory birds in eastern China. Transbound Emerg Dis. 2018 Oct 6. Abstract
submitted by kickingbird at Oct, 11, 2018 from Transbound Emerg Dis. 2018 Oct 6 (via https://www.ncbi.nlm.nih.gov/pubmed/30291732)
Low pathogenic avian influenza virus (LPAIV) is an important zoonotic pathogen. Migratory birds are the natural reservoir for all 16 haemagglutinin (HA) and 9 neuraminidase (NA) subtypes of LPAIV. Surveillance ... Yamayoshi S, Yasuhara A, Ito M, Uraki R, Kawaoka Y. Differences in the ease with which mutant viruses escape from human monoclonal antibodies against the HA stem of influenza A virus. J Clin Virol. 2018 Sep 26;108:105-111. Abstract
submitted by kickingbird at Oct, 11, 2018 from J Clin Virol. 2018 Sep 26;108:105-111 (via https://www.ncbi.nlm.nih.gov/pubmed/30292135)
BACKGROUND: Broadly protective human monoclonal antibodies that recognize the conserved epitopes in the HA of influenza A virus are being developed as therapeutic agents. Emergence of resistant viruses ... Marchenko V, etc.,al. Isolation and characterization of H5Nx highly pathogenic avian influenza viruses of clade 2.3.4.4 in Russia. Virology. 2018 Oct 5;525:216-223. Abstract
submitted by kickingbird at Oct, 10, 2018 from Virology. 2018 Oct 5;525:216-223 (via https://www.ncbi.nlm.nih.gov/pubmed/30296682)
In 2016-2017, several subtypes of the highly pathogenic avian influenza (HPAI) virus were isolated on the territory of Russia. In the autumn of 2016, during the avian influenza virus surveillance in the ... Haag R, et., al. Exploring rigid and flexible core trivalent sialosides for influenza virus inhibition. Chemistry. 2018 Oct 8.. Abstract
submitted by kickingbird at Oct, 10, 2018 from Chemistry. 2018 Oct 8. (via https://www.ncbi.nlm.nih.gov/pubmed/30295350)
We describe the chemical synthesis and binding analysis of functionalizable rigid and flexible core trivalent sialosides bearing oligoethylene glycol (OEG) spacers interacting with spike proteins of influenza ... Hayden FG. et al. Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents. N Engl J Med. 2018 Sep 6;379(10):913-923. Abstract
submitted by kickingbird at Oct, 10, 2018 from N Engl J Med. 2018 Sep 6;379(10):913-923 (via https://www.nejm.org/doi/full/10.1056/NEJMoa1716197)
BackgroundBaloxavir marboxil is a selective inhibitor of influenza cap-dependent endonuclease. It has shown therapeutic activity in preclinical models of influenza A and B virus infections, including strains ... Chang P, Sealy JE, Sadeyen JR, Iqbal M. Amino acid residue 217 in the hemagglutinin glycoprotein is a key mediator of avian influenza H7N9 virus antigenicity. J Virol. 2018 Oct 3. pii: JVI.01627-18. Abstract
submitted by kickingbird at Oct, 6, 2018 from J Virol. 2018 Oct 3. pii: JVI.01627-18 (via https://www.ncbi.nlm.nih.gov/pubmed/30282714)
Avian influenza viruses continue to evolve and acquire mutations that facilitate antigenic drift and virulence change. In 2017, low pathogenicity H7N9 avian influenza viruses evolved to a high pathogenicity ... Wang S, etc.,al. Identification of two residues within the NS1 of H7N9 influenza A virus that critically affect the protein stability and function. Vet Res. 2018 Oct 1;49(1):98. Abstract
submitted by kickingbird at Oct, 6, 2018 from Vet Res. 2018 Oct 1;49(1):98 (via https://www.ncbi.nlm.nih.gov/pubmed/30285871)
The emerging avian-origin H7N9 influenza A virus, which causes mild to lethal human respiratory disease, continues to circulate in China, posing a great threat to public health. Influenza NS1 protein plays ... Mirzaei SG, Shoushtari A, Nouri A. Development and Evaluation of Real-Time RT-PCR Test for Quantitative and Qualitative Recognition of Current H9N2 Subtype Avian Influenza Viruses in Iran. Arch Razi Inst. 2018 Sep;73(3):177-182. Abstract
submitted by kickingbird at Oct, 6, 2018 from Arch Razi Inst. 2018 Sep;73(3):177-182 (via https://www.ncbi.nlm.nih.gov/pubmed/30280837)
Avian influenza H9N2 subtype viruses have had a great impact on Iranian industrial poultry production economy since introduction in the country. To approach Rapid and precise identification of this viruses ... Hatayama K, etc.,al. Combined effect of anti-high-mobility group box-1 monoclonal antibody and peramivir against influenza A virus-induced pneumonia in mice. J Med Virol. 2018 Oct 3. Abstract
submitted by kickingbird at Oct, 6, 2018 from J Med Virol. 2018 Oct 3 (via https://www.ncbi.nlm.nih.gov/pubmed/30281823)
Human pandemic H1N1 2009 influenza virus causes significant morbidity and mortality with severe acute lung injury (ALI) due to excessive inflammatory reaction, even with neuraminidase inhibitor use. The ... Okamoto M, etc.,al. MicroRNA-451a in extracellular, blood-resident vesicles attenuates macrophage and dendritic cell responses to influenza whole-virus vaccine. J Biol Chem. 2018 Oct 3.. Abstract
submitted by kickingbird at Oct, 6, 2018 from J Biol Chem. 2018 Oct 3. (via https://www.ncbi.nlm.nih.gov/pubmed/30282637)
The innate immune system is important for the efficacy of vaccines, but excessive innate immune responses can cause adverse reactions after vaccination. Extracellular vesicles (EVs) are enriched in the ... Fay EJ, etc.,al. Engineered small molecule control of influenza A virus replication. J Virol. 2018 Oct 3.. Abstract
submitted by kickingbird at Oct, 6, 2018 from J Virol. 2018 Oct 3. (via https://www.ncbi.nlm.nih.gov/pubmed/30282710)
Influenza A virus (IAV) remains a global health concern despite the availability of a seasonal vaccine. It is difficult to predict which strains will circulate during influenza season, and therefore extremely ... Jang Y, etc.,al. Salinomycin Inhibits Influenza Virus Infection by Disrupting Endosomal Acidification and Viral Matrix Protein 2 Function. J Virol. 2018 Oct 3. Abstract
submitted by kickingbird at Oct, 6, 2018 from J Virol. 2018 Oct 3 (via https://www.ncbi.nlm.nih.gov/pubmed/30282713)
Screening of chemical libraries with 2,000 synthetic compounds identified salinomycin as a hit against influenza A and B viruses with 50% effective concentrations ranging from 0.4 to 4.3 μM in cells. This ... 5328 items, 20/Page, Page[133/267][|<<] [|<] [131] [132] [133] [134] [135] [136] [137] [138] [139] [140] [>|] [>>|] |
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