Kenney AD, et al. IFITM3 protects the heart during influenza virus infection. Proc Natl Acad Sci U S A. 2019 Aug 26.. Abstract
submitted by kickingbird at Aug, 29, 2019 from Proc Natl Acad Sci U S A. 2019 Aug 26. (via https://www.pnas.org/content/early/2019/08/23/1900784116)
Influenza virus can disseminate from the lungs to the heart in severe infections and can induce cardiac pathology, but this has been difficult to study due to a lack of small animal models. In humans, ...
Lee RTC, et al. Influenza A Hemagglutinin Passage Bias Sites and Host Specificity Mutations. Cells. 2019 Aug 22;8(9).. Abstract
submitted by kickingbird at Aug, 27, 2019 from Cells. 2019 Aug 22;8(9). (via https://www.mdpi.com/2073-4409/8/9/958)
Animal studies aimed at understanding influenza virus mutations that change host specificity to adapt to replication in mammalian hosts are necessarily limited in sample numbers due to high cost and safety ...
Gilbertson B, et al. Inhibition of Influenza A Virus by Human Infant Saliva. Viruses. 2019 Aug 20;11(8). Abstract
submitted by kickingbird at Aug, 25, 2019 from Viruses. 2019 Aug 20;11(8) (via https://www.mdpi.com/1999-4915/11/8/766)
Innate antiviral factors in saliva play a role in protection against respiratory infections. We tested the anti-influenza virus activities of saliva samples taken from human infants, 1-12 months old, with ...
Wang Y, et al. Influenza Virus Infection Induces ZBP1 Expression and Necroptosis in Mouse Lungs. Front Cell Infect Microbiol. 2019 Aug 7;9:286.. Abstract
submitted by kickingbird at Aug, 25, 2019 from Front Cell Infect Microbiol. 2019 Aug 7;9:286. (via https://www.frontiersin.org/articles/10.3389/fcimb.2019.0028)
Programmed cell death and especially necroptosis, a programmed and regulated form of necrosis, have been recently implicated in the progression and outcomes of influenza in mouse models. Moreover, Z-DNA/RNA ...
Liu H, Li J, Chen M, Su J. Glucocorticoid treatment of suspected organizing pneumonia after H7N9 infection: A case report. Medicine (Baltimore). 2019 Aug;98(34):e16839.. Abstract
submitted by kickingbird at Aug, 25, 2019 from Medicine (Baltimore). 2019 Aug;98(34):e16839. (via https://insights.ovid.com/crossref?an=00005792-201908230-000)
RATIONALE: H7N9 infection causes acute respiratory distress syndrome with high mortality. The use of glucocorticoids in the acute phase lessened inflammatory responses. Some case reports suggested that ...
Suttie A, et al. Inventory of molecular markers affecting biological characteristics of avian influenza A viruses. Virus Genes. 2019 Aug 19.. Abstract
submitted by kickingbird at Aug, 21, 2019 from Virus Genes. 2019 Aug 19. (via https://link.springer.com/article/10.1007%2Fs11262-019-01700)
Avian influenza viruses (AIVs) circulate globally, spilling over into domestic poultry and causing zoonotic infections in humans. Fortunately, AIVs are not yet capable of causing sustained human-to-human ...
Pulit-Penaloza JA, et al. Mammalian pathogenicity and transmissibility of a reassortant Eurasian avian-like A(H1N1v) influenza virus associated with human infection in China (2015). Virology. 2019 Aug 10;537:31-35.. Abstract
submitted by kickingbird at Aug, 21, 2019 from Virology. 2019 Aug 10;537:31-35. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Swine-origin (variant) H1 influenza A viruses associated with numerous human infections in North America in recent years have been extensively studied in vitro and in mammalian models to determine their ...
Shen Q, Cho JH. The structure and conformational plasticity of the nonstructural protein 1 of the 1918 influenza A virus. Biochem Biophys Res Commun. 2019 Aug 14.. Abstract
submitted by kickingbird at Aug, 21, 2019 from Biochem Biophys Res Commun. 2019 Aug 14. (via https://www.sciencedirect.com/science/article/pii/S0006291X1)
Nonstructural protein 1 (NS1) is a multifunctional virulence factor of influenza virus. The effector domain (ED) of influenza viruses is capable of binding to a variety of host factors, however, the molecular ...
Arikata M, et al. Efficacy of clarithromycin against H5N1 and H7N9 avian influenza a virus infection in cynomolgus monkeys. Antiviral Res. 2019 Aug 14:1. Abstract
submitted by kickingbird at Aug, 21, 2019 from Antiviral Res. 2019 Aug 14:1 (via https://www.sciencedirect.com/science/article/pii/S016635421)
Clarithromycin (CAM), a 14-membered ring macrolide, has anti-inflammatory and immunomodulatory actions and antiviral effects in seasonal influenza virus infection. We examined the prophylactic and therapeutic ...
Ujie M, et al. Long-term culture of human lung adenocarcinoma A549 cells enhances the replication of human influenza A viruses. J Gen Virol. 2019 Aug 19.. Abstract
submitted by kickingbird at Aug, 21, 2019 from J Gen Virol. 2019 Aug 19. (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Long-term culture of the human lung adenocarcinoma cell line A549 promotes the differentiation of these cells toward an alveolar type II cell phenotype. Here, we evaluated the susceptibility of long-term ...
Hay JA, Laurie K, White M, Riley S. Characterising antibody kinetics from multiple influenza infection and vaccination events in ferrets. PLoS Comput Biol. 2019 Aug 19;15(8):e1007294. Abstract
submitted by kickingbird at Aug, 21, 2019 from PLoS Comput Biol. 2019 Aug 19;15(8):e1007294 (via https://journals.plos.org/ploscompbiol/article?id=10.1371/jo)
The strength and breadth of an individual's antibody repertoire is an important predictor of their response to influenza infection or vaccination. Although progress has been made in understanding qualitatively ...
Yu J, et al. Development and characterization of a reverse genetics system for influenza D virus. J Virol. 2019 Aug 14.. Abstract
submitted by kickingbird at Aug, 18, 2019 from J Virol. 2019 Aug 14. (via https://jvi.asm.org/content/early/2019/08/08/JVI.01186-19)
Influenza D virus (IDV) of the Orthomyxoviridae family has a wide host range and a broad geographical distribution. Recent IDV outbreaks in swine, along with serological and genetic evidence of IDV infection ...
Calderon BM, et al. Dysregulation of M segment gene expression contributes to influenza A virus host restriction. PLoS Pathog. 2019 Aug 15;15(8):e1007892. Abstract
submitted by kickingbird at Aug, 18, 2019 from PLoS Pathog. 2019 Aug 15;15(8):e1007892 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
The M segment of the 2009 pandemic influenza A virus (IAV) has been implicated in its emergence into human populations. To elucidate the genetic contributions of the M segment to host adaptation, and the ...
Liu YM, et al. Exosome-delivered and Y RNA-derived small RNA suppresses influenza virus replication. J Biomed Sci. 2019 Aug 15;26(1):58. Abstract
submitted by kickingbird at Aug, 18, 2019 from J Biomed Sci. 2019 Aug 15;26(1):58 (via https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929)
BACKGROUND: Multiple interplays between viral and host factors are involved in influenza virus replication and pathogenesis. Several small RNAs have recently emerged as important regulators of host response ...
Zheng S, et al. Factors associated with fatality due to avian influenza A(H7N9) infection in China. Clin Infect Dis. 2019 Aug 16. Abstract
submitted by kickingbird at Aug, 18, 2019 from Clin Infect Dis. 2019 Aug 16 (via https://academic.oup.com/cid/advance-article-abstract/doi/10)
BACKGROUND: The high case fatality rate of influenza A H7N9 infected patients has been a major clinical concern.METHODS: To identify the common causes of death due to H7N9 as well as identify risk factors ...
Gou X, Wu X, Shi Y, Zhang K, Huang J. A systematic review and meta-analysis of cross-reactivity of antibodies induced by H7 influenza vaccine. Hum Vaccin Immunother. 2019 Aug 16. Abstract
submitted by kickingbird at Aug, 18, 2019 from Hum Vaccin Immunother. 2019 Aug 16 (via https://www.tandfonline.com/doi/abs/10.1080/21645515.2019.16)
Inoculation with vaccine is the major intervention currently used to prevent influenza infections. However, it will be a challenge to produce and implement a new vaccine when a novel highly pathogenic ...
Wan H, et al. The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain. Nat Microbiol. 2019 Aug 12.. Abstract
submitted by kickingbird at Aug, 15, 2019 from Nat Microbiol. 2019 Aug 12. (via https://www.nature.com/articles/s41564-019-0522-6)
A(H3N2) virus predominated recent influenza seasons, which has resulted in the rigorous investigation of haemagglutinin, but whether neuraminidase (NA) has undergone antigenic change and contributed to ...
Eom G, et al. Diagnosis of Tamiflu-Resistant Influenza Virus in Human Nasal Fluid and Saliva using Surface-enhanced Raman Scattering. ACS Sens. 2019 Aug 13.. Abstract
submitted by kickingbird at Aug, 15, 2019 from ACS Sens. 2019 Aug 13. (via https://pubs.acs.org/doi/10.1021/acssensors.9b00697)
Influenza viruses cause respiratory infection, spread through respiratory secretions and are shed into the nasal secretion and saliva specimens. Therefore, nasal fluid and saliva are effective clinical ...
Ang JC, et al. Comparative Immunogenicity of the 2014-2015 Northern Hemisphere Trivalent IIV and LAIV against Influenza A Viruses in Children. Vaccines (Basel). 2019 Aug 12;7(3).. Abstract
submitted by kickingbird at Aug, 15, 2019 from Vaccines (Basel). 2019 Aug 12;7(3). (via https://www.mdpi.com/2076-393X/7/3/87)
Both inactivated influenza vaccines (IIV) and live-attenuated influenza vaccines (LAIV) have been recommended for administration to children. Children are a high-risk group for severe influenza, and a ...
Zhao Y, et al. Airborne transmission may have played a role in the spread of 2015 highly pathogenic avian influenza outbreaks in the United States. Sci Rep. 2019 Aug 13;9(1):11755.. Abstract
submitted by kickingbird at Aug, 15, 2019 from Sci Rep. 2019 Aug 13;9(1):11755. (via https://www.nature.com/articles/s41598-019-47788-z)
The unprecedented 2015 outbreaks of highly pathogenic avian influenza (HPAI) H5N2 in the U.S. devastated its poultry industry and resulted in over $3 billion economic impacts. Today HPAI continues eroding ...
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