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2019-8-19 10:44:38
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Zima V, et al. Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1. Bioorg Med Chem. 2019 May 17.  Abstract  
submitted by kickingbird at May, 29, 2019 from Bioorg Med Chem. 2019 May 17 (via https://www.sciencedirect.com/science/article/pii/S096808961)
This study focuses on design, synthesis and in vitro evaluation of inhibitory potency of two series of sialylmimetic that target an exosite ("150-cavity") adjacent to the active site of influenza neuraminidases ...

Jagadesh A, et al. Genetic characterization of hemagglutinin (HA) gene of influenza A viruses circulating in Southwest India during 2017 season. Virus Genes. 2019 May 25.  Abstract  
submitted by kickingbird at May, 29, 2019 from Virus Genes. 2019 May 25 (via https://link.springer.com/article/10.1007%2Fs11262-019-01675)
Molecular surveillance of influenza viruses is essential for early detection of novel variants. The aim of the present study was to analyze the hemagglutinin gene of influenza A(H1N1)pdm09 and A(H3N2) ...

Zhang H, et al. Development of a multiplex real-time RT-PCR assay for simultaneous detection and differentiation of influenza A, B, C, and D viruses. Diagn Microbiol Infect Dis. 2019 Apr 29..  Abstract  
submitted by kickingbird at May, 29, 2019 from Diagn Microbiol Infect Dis. 2019 Apr 29. (via https://www.ncbi.nlm.nih.gov/pubmed/31130238)
Influenza is a common and contagious respiratory disease caused by influenza A, B, C, and D viruses (IAV, IBV, ICV, and IDV). A multiplex real-time RT-PCR assay was developed for simultaneous detection ...

Gregianini TS, et al. Dual and Triple Infections With Influenza A and B Viruses: A Case-Control Study in Southern Brazil. J Infect Dis. 2019 May 29.  Abstract  
submitted by kickingbird at May, 29, 2019 from J Infect Dis. 2019 May 29 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
Influenza surveillance is important for disease control and should consider possible coinfection with different viruses, which can be associated with disease severity. This study analyzed 34 459 patients ...

Henning J, et al. Risk factors for H5 avian influenza virus prevalence on urban live bird markets in Jakarta, Indonesia-Evaluation of long-term environmental surveillance data. PLoS One. 2019 May 24;14(5):e0216984..  Abstract  
submitted by kickingbird at May, 29, 2019 from PLoS One. 2019 May 24;14(5):e0216984. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
In the re-emergence of Highly Pathogenic Avian Influenza (HPAI), live bird markets have been identified to play a critical role. In this repeated cross-sectional study, we combined surveillance data collected ...

Iván Martínez-Baz, et al. Remaining effect of influenza vaccines received in prior seasons. The Journal of Infectious Diseases.  Abstract  
submitted by kickingbird at May, 28, 2019 from The Journal of Infectious Diseases (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
This study evaluates the remaining effect of influenza vaccines received in the 5 prior seasons. During 7 influenza seasons 8933 patients were enrolled and 47% were confirmed for influenza. As compared ...

J Hicks, et al. Agricultural and geographic factors shaped the North American 2015 highly pathogenic avian influenza H5N2 outbreak. BioRxiv.  Abstract  
submitted by kickingbird at May, 28, 2019 from BioRxiv (via https://www.biorxiv.org/content/10.1101/645408v1.abstract)
The 2014 – 2015 highly pathogenic avian influenza (HPAI) H5NX outbreak represents the largest and most expensive HPAI outbreak in the United States to date. Despite extensive traditional and molecular ...

Lopez KM, et al. Environmental Sampling Survey of H5N2 Highly Pathogenic Avian Influenza-Infected Layer Chicken Farms in Minnesota and Iowa. Avian Dis. 2018 Dec;62(4):373-380.  Abstract  
submitted by kickingbird at May, 28, 2019 from Avian Dis. 2018 Dec;62(4):373-380 (via https://bioone.org/journals/Avian-Diseases/volume-62/issue-4)
Respiratory secretions, feces, feathers, and eggs of avian influenza-infected hens provide ample sources of virus which heavily contaminate barn and farm environments during a disease outbreak. Environmental ...

Ali M, et al. Prevalence and Phylogenetics of H9N2 in Backyard and Commercial Poultry in Pakistan. Avian Dis. 2018 Dec;62(4):416-424..  Abstract  
submitted by kickingbird at May, 28, 2019 from Avian Dis. 2018 Dec;62(4):416-424. (via https://bioone.org/journals/Avian-Diseases/volume-62/issue-4)
Surveillance of H9N2 is currently focused on areas central to the commercial poultry industry. This study determined the prevalence of H9N2 virus in commercial and backyard poultry flocks in Punjab Province, ...

Oxford JS, Gill D. A possible European origin of the Spanish influenza and the first attempts to reduce mortality to combat superinfecting bacteria: an opinion from a virologist and a military historian. Hum Vaccin Immunother. 2019 May 23:1-4..  Abstract  
submitted by kickingbird at May, 28, 2019 from Hum Vaccin Immunother. 2019 May 23:1-4. (via https://www.tandfonline.com/doi/full/10.1080/21645515.2019.1)
When we reconsider the virology and history of the Spanish Influenza Pandemic, the science of 2018 provides us with tools which did not exist at the time. Two such tools come to mind. The first lies in ...

Nguyen LT, et al. A systematic study towards evolutionary and epidemiological dynamics of currently predominant H5 highly pathogenic avian influenza viruses in Vietnam. Sci Rep. 2019 May 22;9(1):7723..  Abstract  
submitted by kickingbird at May, 26, 2019 from Sci Rep. 2019 May 22;9(1):7723. (via https://www.nature.com/articles/s41598-019-42638-4)
This study aimed to elucidate virus, host and environmental dynamics of Vietnamese H5 highly pathogenic avian influenza viruses (HPAIVs) during 2014-2017. Epidemiologically, H5 HPAIVs were frequently detected ...

Hu B, H?fer CT, Thiele C, Veit M. Cholesterol binding to the transmembrane region of a group 2 HA of Influenza virus is essential for virus replication affecting both virus assembly and HA´s fusion activity. J Virol. 2019 May 22..  Abstract  
submitted by kickingbird at May, 26, 2019 from J Virol. 2019 May 22. (via https://www.ncbi.nlm.nih.gov/pubmed/31118253)
Hemagglutinin (HA) of Influenza virus is incorporated into cholesterol enriched, nanodomains of the plasma membrane. Phylogenetic group 2 HAs contain the conserved cholesterol consensus motif (CCM) YKLW ...

Gilbert PB, et al. HAI and NAI titer correlates of inactivated and live attenuated influenza vaccine efficacy. BMC Infect Dis. 2019 May 22;19(1):453.  Abstract  
submitted by kickingbird at May, 26, 2019 from BMC Infect Dis. 2019 May 22;19(1):453 (via https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128)
BACKGROUND: High hemagglutination inhibition (HAI) and neuraminidase inhibition (NAI) titers are generally associated with reduced influenza risk. While repeated influenza vaccination reduces seroresponse, ...

Zhang Y, et al. Genetic and biological characteristics of avian influenza virus subtype H1N8 in environments related to live poultry markets in China. BMC Infect Dis. 2019 May 22;19(1):458.  Abstract  
submitted by kickingbird at May, 26, 2019 from BMC Infect Dis. 2019 May 22;19(1):458 (via https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128)
BACKGROUND: Since 2008, avian influenza surveillance in poultry-related environments has been conducted annually in China. Samples have been collected from environments including live poultry markets, ...

Leung V, et al. Thermal Stabilization of Viral Vaccines in Low-Cost Sugar Films. Sci Rep. 2019 May 21;9(1):7631.  Abstract  
submitted by kickingbird at May, 24, 2019 from Sci Rep. 2019 May 21;9(1):7631 (via https://www.nature.com/articles/s41598-019-44020-w)
Most currently available vaccines, particularly live vaccines, require the cold chain, as vaccine efficacy can be significantly hampered if they are not stored in a temperature range of 2-8?°C at all times. ...

Yu Z, et al. PB2 and hemagglutinin mutations confer a virulent phenotype on an H1N2 avian influenza virus in mice. Arch Virol. 2019 May 20.  Abstract  
submitted by kickingbird at May, 23, 2019 from Arch Virol. 2019 May 20 (via https://link.springer.com/article/10.1007%2Fs00705-019-04283)
We previously obtained mouse-adapted variants of H1N2 avian influenza virus that contained PB2-L134H, PB2-I647L, PB2-D701N, HA-G228S, and M1-D231N mutations. Here, we analyzed the effects of these mutations ...

Murakami S, et al. Influenza D Virus Infection in Dromedary Camels, Ethiopia. Emerg Infect Dis. 2019 Jun;25(6):1224-1226.  Abstract  
submitted by kickingbird at May, 22, 2019 from Emerg Infect Dis. 2019 Jun;25(6):1224-1226 (via https://wwwnc.cdc.gov/eid/article/25/6/18-1158_article)
Influenza D virus has been found to cause respiratory diseases in livestock. We surveyed healthy dromedary camels in Ethiopia and found a high seroprevalence for this virus, in contrast to animals co-existing ...

Carvalho SB, et al. Membrane-based approach for the downstream processing of influenza virus-like particles. Biotechnol J. 2019 May 20:e201800570.  Abstract  
submitted by kickingbird at May, 22, 2019 from Biotechnol J. 2019 May 20:e201800570 (via https://onlinelibrary.wiley.com/doi/abs/10.1002/biot.2018005)
Currently marketed influenza vaccines are only efficient against homologous viruses, thus requiring a seasonal update based on circulating subtypes. This constant reformulation adds several challenges ...

Nishizawa S, et al. Strong binding and off-on signaling functions of deep-red fluorescent TO-PRO-3 for influenza A virus RNA promoter region. Chembiochem. 2019 May 20..  Abstract  
submitted by kickingbird at May, 22, 2019 from Chembiochem. 2019 May 20. (via https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.2019003)
Influenza A virus RNA promoter region has recently attracted much attention as RNA targets for the development of novel anti-influenza drugs. However, there are very limited reports on small RNA-binding ...

Bajic G, et al. Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope. Cell Host Microbe. 2019 May 14.  Abstract  
submitted by kickingbird at May, 22, 2019 from Cell Host Microbe. 2019 May 14 (via https://www.ncbi.nlm.nih.gov/pubmed/31104946)
Viral glycoproteins are under constant immune surveillance by a host's adaptive immune responses. Antigenic variation including glycan introduction or removal is among the mechanisms viruses have evolved ...

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