Evseenko VA, et al. Comparative thermostability analysis of zoonotic and human influenza virus A and B neuraminidase. Arch Virol. 2019 Nov 19.. Abstract
submitted by kickingbird at Nov, 25, 2019 from Arch Virol. 2019 Nov 19. (via https://www.ncbi.nlm.nih.gov/pubmed/31745716)
Neuraminidase (NA) thermostability of influenza A and B viruses isolated from birds, swine and humans was measured to evaluate its variability associated with host body temperature. The highest 50% inactivation ...
Xu Y, et al. Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin. Cell Rep. 2019 Nov 19;29(8):2217-2228.e5.. Abstract
submitted by kickingbird at Nov, 25, 2019 from Cell Rep. 2019 Nov 19;29(8):2217-2228.e5. (via https://www.ncbi.nlm.nih.gov/pubmed/31747596)
Since 2013, H7N9 avian influenza viruses (AIVs) have caused more than 1,600 human infections, posing a threat to public health. An emerging concern is whether H7N9 AIVs will cause pandemics among humans. ...
Fusaro A, et al. Disentangling the role of Africa in the global spread of H5 highly pathogenic avian influenza. Nat Commun. 2019 Nov 22;10(1):5310.. Abstract
submitted by kickingbird at Nov, 25, 2019 from Nat Commun. 2019 Nov 22;10(1):5310. (via https://www.ncbi.nlm.nih.gov/pubmed/31757953)
The role of Africa in the dynamics of the global spread of a zoonotic and economically-important virus, such as the highly pathogenic avian influenza (HPAI) H5Nx of the Gs/GD lineage, remains unexplored. ...
Gilchuk IM, et al. Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice. Cell Host Microbe. 2019 Nov 1.. Abstract
submitted by kickingbird at Nov, 25, 2019 from Cell Host Microbe. 2019 Nov 1. (via https://www.ncbi.nlm.nih.gov/pubmed/31757769)
H7N9 avian influenza virus causes severe infections and might have the potential to trigger a major pandemic. Molecular determinants of human humoral immune response to N9 neuraminidase (NA) proteins, ...
Zhu X, et al. Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. Cell Host Microbe. 2019 Oct 24. Abstract
submitted by kickingbird at Nov, 25, 2019 from Cell Host Microbe. 2019 Oct 24 (via https://www.ncbi.nlm.nih.gov/pubmed/31757767)
Influenza virus neuraminidase (NA) is a major target for small-molecule antiviral drugs. Antibodies targeting the NA surface antigen could also inhibit virus entry and egress to provide host protection. ...
Chen G, et al. A double-stranded RNA platform is required for the interaction between a host restriction factor and the NS1 protein of influenza A virus. Nucleic Acids Res. 2019 Nov 22.. Abstract
submitted by kickingbird at Nov, 25, 2019 from Nucleic Acids Res. 2019 Nov 22. (via https://academic.oup.com/nar/advance-article/doi/10.1093/nar)
Influenza A viruses cause widespread human respiratory disease. The viral multifunctional NS1 protein inhibits host antiviral responses. This inhibition results from the binding of specific cellular antiviral ...
Wang J, Wiltse A, Zand MS. A Complex Dance: Measuring the Multidimensional Worlds of Influenza Virus Evolution and Anti-Influenza Immune Responses. Pathogens. 2019 Nov 15;8(4). Abstract
submitted by kickingbird at Nov, 18, 2019 from Pathogens. 2019 Nov 15;8(4) (via https://www.mdpi.com/2076-0817/8/4/238)
The human antibody response to influenza virus infection or vaccination is as complicated as it is essential for protection against flu. The constant antigenic changes of the virus to escape human herd ...
Londrigan SL, et al. IFITM3 and type I interferons are important for the control of influenza A virus replication in murine macrophages. Virology. 2019 Nov 5;540:17-22.. Abstract
submitted by kickingbird at Nov, 18, 2019 from Virology. 2019 Nov 5;540:17-22. (via https://www.ncbi.nlm.nih.gov/pubmed/31731106)
Abortive infection of macrophages serves as a "dead end" for most seasonal influenza A virus (IAV) strains, and it is likely to contribute to effective host defence. Interferon (IFN)-induced transmembrane ...
Harding AT, Haas GD, Chambers BS, Heaton NS. Influenza viruses that require 10 genomic segments as antiviral therapeutics. PLoS Pathog. 2019 Nov 15;15(11):e1008098.. Abstract
submitted by kickingbird at Nov, 18, 2019 from PLoS Pathog. 2019 Nov 15;15(11):e1008098. (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A viruses (IAVs) encode their genome across eight, negative sense RNA segments. During viral assembly, the failure to package all eight segments, or packaging a mutated segment, renders the resulting ...
Li R, Zhang T, Xu J, Chang J, Xu B. Novel Reassortant Avian Influenza A(H3N8) Virus Isolated from a Wild Bird in Jiangxi, China. Microbiol Resour Announc. 2019 Nov 14;8(46).. Abstract
submitted by kickingbird at Nov, 18, 2019 from Microbiol Resour Announc. 2019 Nov 14;8(46). (via https://mra.asm.org/content/8/46/e01163-19)
Here, we report the detection of a reassortant avian influenza A(H3N8) virus isolated from a wild bird in Poyang Lake, Jiangxi, China, in 2014. Phylogenetic analyses indicated that this virus is most likely ...
Brazee PL, et al. Linear ubiquitin assembly complex regulates lung epithelial driven responses during influenza infection. J Clin Invest. 2019 Nov 12.. Abstract
submitted by kickingbird at Nov, 14, 2019 from J Clin Invest. 2019 Nov 12. (via https://www.jci.org/articles/view/128368)
Influenza A virus (IAV) is among the most common causes of pneumonia related death worldwide. Pulmonary epithelial cells are the primary target for viral infection and replication and respond by releasing ...
Wang S, et al. Reverse transcription recombinase-aided amplification assay for H7 subtype avian influenza virus. Transbound Emerg Dis. 2019 Nov 12.. Abstract
submitted by kickingbird at Nov, 14, 2019 from Transbound Emerg Dis. 2019 Nov 12. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13411)
H7 subtype avian influenza virus infection is an emerging zoonosis in some Asian countries and an important avian disease worldwide. A rapid and simple test is needed to confirm infection in suspected ...
Muzyka D, et al. Highly Pathogenic and Low Pathogenic Avian Influenza H5 Subtype Viruses in Wild Birds in Ukraine. Avian Dis. 2019 Mar 1;63(sp1):235-245.. Abstract
submitted by kickingbird at Nov, 14, 2019 from Avian Dis. 2019 Mar 1;63(sp1):235-245. (via https://www.ncbi.nlm.nih.gov/pubmed/31713401)
There have been three waves of highly pathogenic avian influenza (HPAI) outbreaks in commercial, backyard poultry, and wild birds in Ukraine. The first (2005-2006) and second (2008) waves were caused by ...
Sultan HA, et al. Efficacy of Clade 2.3.2 H5-Recombinant Baculovirus Vaccine in Protecting Muscovy and Pekin Ducks from Clade 22.214.171.124 H5N8 Highly Pathogenic Avian Influenza Infection. Avian Dis. 2019 Mar 1;63(sp1):219-229.. Abstract
submitted by kickingbird at Nov, 14, 2019 from Avian Dis. 2019 Mar 1;63(sp1):219-229. (via https://www.ncbi.nlm.nih.gov/pubmed/31713400)
In late 2016, a highly pathogenic avian influenza (HPAI) virus subtype H5N8 clade 126.96.36.199 was reported in Egypt in migratory birds; subsequently, the virus spread to backyard and commercial poultry in ...
Schreiber A, et al. Type I interferon antagonistic properties of Influenza B virus polymerase proteins. Cell Microbiol. 2019 Nov 11:e13143. Abstract
submitted by kickingbird at Nov, 14, 2019 from Cell Microbiol. 2019 Nov 11:e13143 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.13143)
The innate immune system, in particular the type I interferon (IFN) response, is a powerful defense against virus infections. In turn, many if not all viruses have evolved various means to circumvent, ...
Antanasijevic A, Durst MA, Lavie A, Caffrey M. Identification of a pH Sensor in Influenza Hemagglutinin using X-ray Crystallography. J Struct Biol. 2019 Nov 2:107412. Abstract
submitted by kickingbird at Nov, 11, 2019 from J Struct Biol. 2019 Nov 2:107412 (via https://www.ncbi.nlm.nih.gov/pubmed/31689502)
Hemagglutnin (HA) mediates entry of influenza virus through a series of conformational changes triggered by the low pH of the endosome. The residue or combination of residues acting as pH sensors has not ...
Kwon HI, et al. A Novel Neuraminidase-Dependent Hemagglutinin Cleavage Mechanism Enables the Systemic Spread of an H7N6 Avian Influenza Virus. MBio. 2019 Nov 5;10(6). Abstract
submitted by kickingbird at Nov, 11, 2019 from MBio. 2019 Nov 5;10(6) (via https://mbio.asm.org/content/10/6/e02369-19)
n this study, we demonstrate a novel mechanism for hemagglutinin (HA) activation in a naturally occurring H7N6 avian influenza A virus strain, A/mallard duck/Korea/6L/2007 (A/Mdk/6L/07). This novel mechanism ...
Seki M, Sakai-Tagawa Y, Yasuhara A, Watanabe Y. Adult influenza A (H3N2) with reduced susceptibility to baloxavir or peramivir cured after switching anti-influenza agents. IDCases. 2019 Oct 1;18:e00650.. Abstract
submitted by kickingbird at Nov, 11, 2019 from IDCases. 2019 Oct 1;18:e00650. (via https://www.ncbi.nlm.nih.gov/pubmed/31692637)
We describe two adults with A/H3N2 influenza with (patient 1), and without (patient 2) polymerase acidic (PA) subunit I38?T substitution during the same season. Patient 1 had a reduced clinical response ...
Coombs KM, et al. Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses. Viruses. 2019 Nov 5;11(11).. Abstract
submitted by kickingbird at Nov, 11, 2019 from Viruses. 2019 Nov 5;11(11). (via https://www.mdpi.com/1999-4915/11/11/1028)
Influenza A viruses (IAVs) are important animal and human emerging and re-emerging pathogens that are responsible for yearly seasonal epidemics and sporadic pandemics. IAVs cause a wide range of clinical ...
Gambaryan AS, et al. Changes in the Receptor-Binding Properties of H3N2 Viruses during Long-Term Circulation in Humans. Biochemistry (Mosc). 2019 Oct;84(10):1177-1185. Abstract
submitted by kickingbird at Nov, 11, 2019 from Biochemistry (Mosc). 2019 Oct;84(10):1177-1185 (via https://www.ncbi.nlm.nih.gov/pubmed/31694513)
It was previously shown that hemagglutinin residues Thr155, Glu158, and Ser228 are crucial for the recognition of Neu5Gc. In this study, we demonstrated that the ability to bind the Neu5Gc-terminated receptor ...
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