Zhang N, Zhu L, Zhang Y, et al. Circulating Rather Than Alveolar Extracellular DNA Levels Predict Outcomes in Influenza. J Infect Dis. 2020;jiaa241. Abstract
submitted by kickingbird at May, 23, 2020 from J Infect Dis. 2020;jiaa241 (via https://pubmed.ncbi.nlm.nih.gov/32436580)
Background: High levels of circulating neutrophil extracellular traps (NETs) are associated with a poor prognosis in influenza A infection. It remains unclear whether NETs in the plasma or bronchoalveolar ...
Willgert K, Meyer A, Tung DX, et al. Transmission of Highly Pathogenic Avian Influenza in the Nomadic Free-Grazing Duck Production System in Viet Nam. Sci Rep. 2020;10(1):8432. Abstract
submitted by kickingbird at May, 23, 2020 from Sci Rep. 2020;10(1):8432 (via https://pubmed.ncbi.nlm.nih.gov/32439997)
The presence of free-grazing ducks (FGD) has consistently been shown to be associated with highly pathogenic avian influenza virus (HPAIV) H5N1 outbreaks in South-East Asia. However, the lack of knowledge ...
Kaul D, Rathnasinghe R, Ferres M, et al. Microbiome Disturbance and Resilience Dynamics of the Upper Respiratory Tract During Influenza A Virus Infection. Nat Commun. 2020;11(1):2537. Abstract
submitted by kickingbird at May, 23, 2020 from Nat Commun. 2020;11(1):2537 (via https://pubmed.ncbi.nlm.nih.gov/32439901)
Infection with influenza can be aggravated by bacterial co-infections, which often results in disease exacerbation. The effects of influenza infection on the upper respiratory tract (URT) microbiome are ...
Laconi A, Fortin A, Bedendo G, et al. Detection of Avian Influenza Virus: A Comparative Study of the in Silico and in Vitro Performances of Current RT-qPCR Assays. Sci Rep. 2020;10(1):8441.. Abstract
submitted by kickingbird at May, 23, 2020 from Sci Rep. 2020;10(1):8441. (via https://pubmed.ncbi.nlm.nih.gov/32439885)
Avian influenza viruses (AIV) are negative sense RNA viruses posing a major threat to the poultry industry worldwide, with the potential to spread to mammals, including humans; hence, an accurate and rapid ...
Gouma S, Weirick M, Hensley SE. Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine. Nat Commun. 2020 May 15;11(1):2445. Abstract
submitted by kickingbird at May, 18, 2020 from Nat Commun. 2020 May 15;11(1):2445 (via https://www.nature.com/articles/s41467-020-16183-y)
The 2019-2020 Northern Hemisphere influenza vaccine includes antigens from 3c3.A H3N2 viruses; however, over half of circulating H3N2 viruses belong to subclade 3c2.A1b. Here, we analyze antibody responses ...
Kato Y, et al. Novel oseltamivir-resistant mutations distant from the active site of influenza B neuraminidase. J Biomol Struct Dyn. 2020 May 14:1-17.. Abstract
submitted by kickingbird at May, 17, 2020 from J Biomol Struct Dyn. 2020 May 14:1-17. (via https://www.ncbi.nlm.nih.gov/pubmed/32406800)
We performed a neuraminidase sequence analysis of thirty-two pediatric patients with influenza B who visited Teikyo University Hospital from January 2016 to March 2017, and found oseltamivir-resistant ...
Banerjee A, Mossman KL, Miller MS. Bat Influenza Viruses: Making a Double Agent of MHC Class II. Trends Microbiol. 2020 Apr 20.. Abstract
submitted by kickingbird at May, 17, 2020 from Trends Microbiol. 2020 Apr 20. (via https://www.ncbi.nlm.nih.gov/pubmed/32409145)
MHC class II (MHCII) has recently been identified as a cellular receptor for bat influenza viruses. Here, we discuss the possible implications of viral exploitation of this critical host defense molecule ...
Liu T, et al. Discovery of dihydropyrrolidones as novel inhibitors against influenza A virus. Eur J Med Chem. 2020 May 4;199:. Abstract
submitted by kickingbird at May, 17, 2020 from Eur J Med Chem. 2020 May 4;199: (via https://www.ncbi.nlm.nih.gov/pubmed/32408213)
More effective prophylactic and therapeutic strategies to combat influenza viruses are urgently required worldwide because the conventional anti-influenza drugs are facing drug resistance. Here, dihydropyrrolidones ...
Xie XT, et al. A within-host mathematical model of H9N2 avian influenza infection and type-I interferon response pathways in chickens. J Theor Biol. 2020 May 11:110320.. Abstract
submitted by kickingbird at May, 17, 2020 from J Theor Biol. 2020 May 11:110320. (via https://www.ncbi.nlm.nih.gov/pubmed/32407720)
Chickens infected with avian influenza virus (AIV) transmit the virus via respiratory and cloacal shedding. While previous mathematical models have shown that the innate immune response is necessary for ...
de Jonge J, et al. H7N9 influenza split vaccine with SWE oil-in-water adjuvant greatly enhances cross-reactive humoral immunity and protection against severe pneumonia in ferrets. NPJ Vaccines. 2020 May 11;5:38. Abstract
submitted by kickingbird at May, 17, 2020 from NPJ Vaccines. 2020 May 11;5:38 (via https://www.nature.com/articles/s41541-020-0187-4)
Until universal influenza vaccines become available, pandemic preparedness should include developing classical vaccines against potential pandemic influenza subtypes. We here show that addition of SWE ...
Hu C, et al. Co-circulation of multiple reassortant H6 subtype avian influenza viruses in wild birds in eastern China, 2016-2017. Virol J. 2020 Apr 29;17(1):62.. Abstract
submitted by kickingbird at May, 3, 2020 from Virol J. 2020 Apr 29;17(1):62. (via https://www.ncbi.nlm.nih.gov/pubmed/32349760)
BACKGROUND: H6 subtype influenza viruses were prevalent in domestic poultry and wild birds, which also could pose potential threat to humans. However, little is known about the prevalence of H6 subtype ...
Mine J, Uchida Y, Takemae N, Saito T. Genetic characterization of influenza A viruses in Japanese swine during 2015-2019. J Virol. 2020 Apr 29. pii: JVI.02169-19.. Abstract
submitted by kickingbird at May, 3, 2020 from J Virol. 2020 Apr 29. pii: JVI.02169-19. (via https://www.ncbi.nlm.nih.gov/pubmed/32350072)
To assess the current status of influenza A viruses of swine (IAVs-S) throughout Japan and to investigate how these viruses persisted and evolve on pig farms, we genetically characterized IAVs-S isolated ...
Kesavardhana S, et al. The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development.. J Biol Chem. 2020 Apr 29.. Abstract
submitted by kickingbird at May, 3, 2020 from J Biol Chem. 2020 Apr 29. (via https://www.jbc.org/content/early/2020/04/29/jbc.RA120.01375)
Z-DNA-binding protein 1 (ZBP1) is an innate immune sensor of nucleic acids that regulates both host defense responses and development. ZBP1 activation triggers inflammation and pyroptosis, necroptosis, ...
Yudhawati R, et al. Comparison of virulence and lethality in mice for two avian influenza A/H5N1 and one A/H3N6 viruses isolated from poultry during 2013 to 2014 in Indonesia. Jpn J Infect Dis. 2020 Apr 30.. Abstract
submitted by kickingbird at May, 3, 2020 from Jpn J Infect Dis. 2020 Apr 30. (via https://www.jstage.jst.go.jp/article/yoken/advpub/0/advpub_J)
In Indonesia, highly pathogenic avian influenza A/H5N1 virus has become endemic and was linked to direct transmission to humans. During 2013 to 2014, we isolated avian influenza A/H5N1 and A/H3N6 viruses ...
Shin J, et al. Highly pathogenic H5N6 avian influenza virus subtype clade 18.104.22.168 indigenous in South Korea. Sci Rep. 2020 Apr 29;10(1):7241. Abstract
submitted by kickingbird at May, 3, 2020 from Sci Rep. 2020 Apr 29;10(1):7241 (via https://www.ncbi.nlm.nih.gov/pubmed/32350323)
The outbreaks of the highly pathogenic avian influenza (HPAI) in 2016-2017 and 2017-2018, caused by novel reassortant clade 22.214.171.124 H5N6 viruses, resulted in the loss of one billion birds in South Korea. ...
Noll KE, et al. Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross. Cell Rep. 2020 Apr 28;31(4):107587.. Abstract
submitted by kickingbird at May, 1, 2020 from Cell Rep. 2020 Apr 28;31(4):107587. (via https://www.ncbi.nlm.nih.gov/pubmed/32348764)
Host genetic factors play a fundamental role in regulating humoral immunity to viral infection, including influenza A virus (IAV). Here, we utilize the Collaborative Cross (CC), a mouse genetic reference ...
Filgueiras-Rama D, et al. Human Influenza A virus causes myocardial and cardiac-specific conduction system infection associated with early inflammation and premature death. Cardiovasc Res. 2020 Apr 28. Abstract
submitted by kickingbird at May, 1, 2020 from Cardiovasc Res. 2020 Apr 28 (via https://www.ncbi.nlm.nih.gov/pubmed/32346730)
AIMS: Human influenza A virus (hIAV) infection is associated with important cardiovascular complications, although cardiac infection pathophysiology is poorly understood. We aimed to study the ability ...
Zhang Q, et al. Influenza infection elicits an expansion of gut population of endogenous Bifidobacterium animalis which protects mice against infection. Genome Biol. 2020 Apr 28;21(1):99.. Abstract
submitted by kickingbird at May, 1, 2020 from Genome Biol. 2020 Apr 28;21(1):99. (via https://www.ncbi.nlm.nih.gov/pubmed/32345342)
BACKGROUND: Influenza is a severe respiratory illness that continually threatens global health. It has been widely known that gut microbiota modulates the host response to protect against influenza infection, ...
Tsuzuki S, Yoshihara K. The characteristics of influenza-like illness management in Japan. BMC Public Health. 2020 Apr 28;20(1):568.. Abstract
submitted by kickingbird at May, 1, 2020 from BMC Public Health. 2020 Apr 28;20(1):568. (via https://www.ncbi.nlm.nih.gov/pubmed/32345248)
BACKGROUND: This study aimed to make a quantitative assessment of the management of influenza-like illnesses (ILI) in Japanese healthcare settings.METHODS: We analysed participants' healthcare-seeking ...
Abed Y, et al. Characterization of contemporary influenza B recombinant viruses harboring mutations of reduced susceptibility to baloxavir marboxil, in vitro and in mice. Antiviral Res. 2020 Apr 25:104807.. Abstract
submitted by kickingbird at May, 1, 2020 from Antiviral Res. 2020 Apr 25:104807. (via https://www.ncbi.nlm.nih.gov/pubmed/32343991)
Baloxavir marboxil (BXM) is a potent inhibitor of the polymerase acidic (PA) protein of influenza viruses. However, clinical trials predominantly involving influenza A(H1N1) and A(H3N2) infections showed ...
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