Jiang L, Samant N, Liu P, Somasundaran M, Jensen J. Identification of a permissive secondary mutation that restores the enzymatic activity of oseltamivir resistance mutation H275Y. J Virol. 2022 Jan 19:jvi0198221. Abstract
submitted by kickingbird at Jan, 20, 2022 from J Virol. 2022 Jan 19:jvi0198221 (via https://journals.asm.org/doi/10.1128/jvi.01982-21)
Many oseltamivir resistance mutations exhibit fitness defects in the absence of drug pressure that hinders their propagation in hosts. Secondary permissive mutations can rescue fitness defects and facilitate ...
Encinas P, Del Real G, Dutta J, Khan Z, van Bakel. Evolution of influenza A virus in intensive and free-range swine farms in Spain. Virus Evol. 2021 Nov 30;7(2):veab099. Abstract
submitted by kickingbird at Jan, 19, 2022 from Virus Evol. 2021 Nov 30;7(2):veab099 (via https://academic.oup.com/ve/article/7/2/veab099/6446465)
Swine harbor genetically diverse influenza A viruses (IAVs) with the capacity to host-switch to humans, causing global pandemics. Spain is the largest swine producer in Europe and has a mixed production ...
Qiao Y, Jin S, Nie J, Chang Y, Wang B, Guan S, Li. Hemagglutinin-based DNA vaccines containing trimeric self-assembling nanoparticles confer protection against influenza. J Leukoc Biol. 2022 Jan 17. Abstract
submitted by kickingbird at Jan, 19, 2022 from J Leukoc Biol. 2022 Jan 17 (via https://jlb.onlinelibrary.wiley.com/doi/10.1002/JLB.6A1021-5)
Influenza viruses continue to threaten public health, and currently available vaccines provide insufficient immunity against seasonal and pandemic influenza. The use of recombinant trimeric hemagglutinin ...
Goettler D, Niekler P, Liese JG, Streng A. Epidemiology and direct healthcare costs of Influenza-associated hospitalizations - nationwide inpatient data (Germany 2010-2019). BMC Public Health. 2022 Jan 15;22(1):108. Abstract
submitted by kickingbird at Jan, 18, 2022 from BMC Public Health. 2022 Jan 15;22(1):108 (via https://bmcpublichealth.biomedcentral.com/articles/10.1186/s)
Introduction: Detailed and up-to-date data on the epidemiology and healthcare costs of Influenza are fundamental for public health decision-making. We analyzed inpatient data on Influenza-associated hospitalizations ...
Gao X, Wang N, Chen Y, Gu X, Huang Y, Liu Y, Jiang. Sequence characteristics and phylogenetic analysis of H9N2 subtype avian influenza A viruses detected from poultry and the environment in China, 2018. PeerJ. 2021 Dec 20;9:e12512. Abstract
submitted by kickingbird at Jan, 18, 2022 from PeerJ. 2021 Dec 20;9:e12512 (via https://peerj.com/articles/12512/)
H9N2 subtype avian influenza A virus (AIV) is a causative agent that poses serious threats to both the poultry industry and global public health. In this study, we performed active surveillance to identify ...
Liu L, Li Z, Zhou J, Liu J, Li X, Huang W, Xiao N,. Homologous PB1 gene promotes the replication efficiency of avian influenza H7N4 candidate vaccine virus. Influenza Other Respir Viruses. 2022 Jan 17. Abstract
submitted by kickingbird at Jan, 18, 2022 from Influenza Other Respir Viruses. 2022 Jan 17 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.12954)
Background: The first and only case of human infection with the avian influenza A (H7N4) virus in China emerged in 2018. The H7N4 virus was distinct from previous H7N9 viruses and raised public concerns. ...
Tang H, Kang J, Shen C, Wang Y, Robertson ID, Cai. Benefit-cost analysis of a H7N9 vaccination program in poultry in Guangxi, China. Prev Vet Med. 2022 Jan 8;200:105580. Abstract
submitted by kickingbird at Jan, 17, 2022 from Prev Vet Med. 2022 Jan 8;200:105580 (via https://www.sciencedirect.com/science/article/abs/pii/S01675)
China launched a H7N9 vaccination program in poultry, starting from the Guangxi and Guangdong provinces in July 2017, followed by other provinces in September 2017, as a response to a steep increase of ...
Peterson JM, O´Leary CA, Moss WN. In silico analysis of local RNA secondary structure in influenza virus A, B and C finds evidence of widespread ordered stability but little evidence of significant covariation. Sci Rep. 2022 Jan 10;12(1):310. Abstract
submitted by kickingbird at Jan, 13, 2022 from Sci Rep. 2022 Jan 10;12(1):310 (via https://www.nature.com/articles/s41598-021-03767-x)
Influenza virus is a persistent threat to human health; indeed, the deadliest modern pandemic was in 1918 when an H1N1 virus killed an estimated 50 million people globally. The intent of this work is to ...
Omer I, Rosenberg A, Sefty H, Pando R, Mandelboim. Lineage-matched versus mismatched influenza B vaccine effectiveness following seasons of marginal influenza B circulation. Vaccine. 2022 Jan 8:S0264-410X(21)01664-9. Abstract
submitted by kickingbird at Jan, 13, 2022 from Vaccine. 2022 Jan 8:S0264-410X(21)01664-9 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Background: Several countries have recently transitioned from the trivalent inactivated influenza vaccine (TIV) to the quadrivalent inactivated influenza vaccine (QIV) in order to outweigh influenza B ...
Liu T, Wang P, Meng F, Ding G, Wu J, Song S, Sun L. Incidence, circulation, and spatiotemporal analysis of seasonal influenza in Shandong, China, 2008-2019: A retrospective study. Influenza Other Respir Viruses. 2022 Jan 11. Abstract
submitted by kickingbird at Jan, 13, 2022 from Influenza Other Respir Viruses. 2022 Jan 11 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.12959)
Background: Understanding the influenza-like illness (ILI) incidence, circulation pattern of virus strains and spatiotemporal pattern of influenza transmission are important for designing control interventions. ...
Bhat S, James J, Sadeyen JR, Mahmood S, Everest HJ. Co-infection of chickens with H9N2 and H7N9 avian influenza viruses leads to emergence of reassortant H9N9 virus with increased fitness for poultry and a zoonotic potential. J Virol. 2022 Jan 12:jvi0185621. Abstract
submitted by kickingbird at Jan, 13, 2022 from J Virol. 2022 Jan 12:jvi0185621 (via https://journals.asm.org/doi/10.1128/jvi.01856-21)
An H7N9 low pathogenicity avian influenza virus (LPAIV) emerged in 2013 through genetic reassortment between H9N2 and other LPAIVs circulating in birds in China. This virus causes inapparent clinical disease ...
Veler H, Fan H, Keown J, Sharps J, Fournier M, Gri. The C-terminal domains of the PB2 subunit of the influenza A virus RNA polymerase directly interact with cellular GTPase Rab11a. J Virol. 2022 Jan 12:jvi0197921. Abstract
submitted by kickingbird at Jan, 13, 2022 from J Virol. 2022 Jan 12:jvi0197921 (via https://journals.asm.org/doi/10.1128/jvi.01979-21)
Influenza A virus (IAV) contains a segmented RNA genome that is transcribed and replicated by the viral RNA polymerase in the cell nucleus. Replicated RNA segments are assembled with viral polymerase and ...
Rashid MU, Gao A, Coombs KM. Influenza A virus uses PSMA2 for downregulation of NRF2-mediated oxidative stress response. J Virol. 2022 Jan 12:jvi0199021. Abstract
submitted by kickingbird at Jan, 13, 2022 from J Virol. 2022 Jan 12:jvi0199021 (via https://journals.asm.org/doi/10.1128/jvi.01990-21)
Influenza A virus (IAV), an obligatory intracellular parasite, uses host cellular molecules to complete its replication cycle and suppress immune responses. Proteasome subunit alpha type-2 (PSMA2) is a ...
Yan W, Cui H, Engelsma M, Beerens N, van Oers MM,. Molecular and Antigenic Characterization of Avian H9N2 Viruses in Southern China. Microbiol Spectr. 2022 Jan 12:e0082221. Abstract
submitted by kickingbird at Jan, 13, 2022 from Microbiol Spectr. 2022 Jan 12:e0082221 (via https://journals.asm.org/doi/10.1128/spectrum.00822-21)
The H9N2 subtype avian influenza virus (AIV) has become endemic in poultry globally; however due to its low pathogenicity, it is not under primary surveillance and control in many countries. Recent reports ...
Sharma A, Zeller MA, Souza CK, Anderson TK, Vincen. Characterization of a 2016-2017 Human Seasonal H3 Influenza A Virus Spillover Now Endemic to U.S. Swine. mSphere. 2022 Jan 12:e0080921. Abstract
submitted by kickingbird at Jan, 13, 2022 from mSphere. 2022 Jan 12:e0080921 (via https://journals.asm.org/doi/10.1128/msphere.00809-21)
In 2017, the Iowa State University Veterinary Diagnostic Laboratory detected a reverse-zoonotic transmission of a human seasonal H3 influenza A virus into swine (IAV-S) in Oklahoma. Pairwise comparison ...
Keown JR, Zhu Z, Carrique L, Fan H, Walker AP, Ser. Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nat Commun. 2022 Jan 11;13(1):251. Abstract
submitted by kickingbird at Jan, 13, 2022 from Nat Commun. 2022 Jan 11;13(1):251 (via https://www.nature.com/articles/s41467-021-27950-w)
Influenza A viruses cause seasonal epidemics and global pandemics, representing a considerable burden to healthcare systems. Central to the replication cycle of influenza viruses is the viral RNA-dependent ...
Soudani S, Mafi A, Al Mayahi Z, Al Balushi S, Dbai. A Systematic Review of Influenza Epidemiology and Surveillance in the Eastern Mediterranean and North African Region. Infect Dis Ther. 2022 Jan 8. Abstract
submitted by kickingbird at Jan, 10, 2022 from Infect Dis Ther. 2022 Jan 8 (via https://link.springer.com/article/10.1007%2Fs40121-021-00534)
Seasonal influenza represents a huge health burden, resulting in significant mortality and morbidity. Following the 2009 H1N1 pandemic, focus has been directed on the burden of influenza globally. Country ...
Vu TH, Hong Y, Truong AD, Lee S, Heo J, Lillehoj H. The highly pathogenic H5N1 avian influenza virus induces the MAPK signaling pathway in the trachea of two Ri chicken lines. Anim Biosci. 2022 Jan 5. Abstract
submitted by kickingbird at Jan, 10, 2022 from Anim Biosci. 2022 Jan 5 (via https://www.animbiosci.org/journal/view.php?doi=10.5713/ab.2)
Objective: The highly pathogenic avian influenza virus (HPAIV) is a threat to the poultry industry and economy and remains a potential source of pandemic infection in humans. Antiviral genes are considered ...
Sheikh A, Jackson J, Shim HB, Yau C, Seo JH, Abrah. Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection. Sci Rep. 2022 Jan 7;12(1):135. Abstract
submitted by kickingbird at Jan, 10, 2022 from Sci Rep. 2022 Jan 7;12(1):135 (via https://www.nature.com/articles/s41598-021-03936-y)
Interleukin-7 (IL-7) is a cytokine known for its importance in T cell development and survival. How IL-7 shapes CD8 T cell responses during an acute viral infection is less understood. We had previously ...
Huang X, Lu F, Tian H, Hu H, Ning F, Shang Q, Hao. Association between plasma glycocalyx component levels and poor prognosis in severe influenza type A (H1N1). Sci Rep. 2022 Jan 7;12(1):163. Abstract
submitted by kickingbird at Jan, 10, 2022 from Sci Rep. 2022 Jan 7;12(1):163 (via https://www.nature.com/articles/s41598-021-04146-2)
Influenza A virus infection causes a series of diseases, but the factors associated with disease severity are not fully understood. Disruption of the endothelial glycocalyx contributes to acute lung injury ...
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