Deleu S, etc.,al. Single- and Multiple-dose Pharmacokinetics and Safety of Pimodivir, a Novel, Non-Nucleoside Polymerase Basic Protein 2 Subunit Inhibitor of the Influenza A Virus Polymerase Complex, and Interaction Wi. Br J Clin Pharmacol. 2018 Aug 11. Abstract
submitted by kickingbird at Aug, 16, 2018 from Br J Clin Pharmacol. 2018 Aug 11 (via https://www.ncbi.nlm.nih.gov/pubmed/30098042)
AIM: Evaluate the drug-drug interaction between pimodivir, a novel, non-nucleoside polymerase basic protein 2 (PB2) subunit inhibitor of the influenza A virus polymerase complex, and oseltamivir, to assess ... Park HS, Liu G, Liu Q, Zhou Y. Swine Influenza Virus Induces RIPK1/DRP1-Mediated Interleukin-1 Beta Production. Viruses. 2018 Aug 9;10(8).. Abstract
submitted by kickingbird at Aug, 16, 2018 from Viruses. 2018 Aug 9;10(8). (via https://www.ncbi.nlm.nih.gov/pubmed/30096906)
Nucleotide-binding domain and leucine-rich repeat-containing protein 3 (NLRP3) inflammasome plays a pivotal role in modulating lung inflammation in response to the influenza A virus infection. We previously ... Matsuzaki Y, Sugawara K, Furuse Y, Shimotai Y. Neutralizing Epitopes and Residues Mediating the Potential Antigenic Drift of the Hemagglutinin-Esterase Protein of Influenza C Virus. Viruses. 2018 Aug 9;10(8).. Abstract
submitted by kickingbird at Aug, 16, 2018 from Viruses. 2018 Aug 9;10(8). (via https://www.ncbi.nlm.nih.gov/pubmed/30096880)
We mapped the hemagglutinin-esterase (HE) antigenic epitopes of the influenza C virus on the three-dimensional (3D) structure of the HE glycoprotein using 246 escape mutants that were selected by a panel ... Miller PDE, etc.,al. Sociodemographic and psychological determinants of influenza vaccine intention among recipients of autologous and allogeneic haematopoietic stem cell transplant: a cross-sectional survey of UK transpl. BMJ Open. 2018 Aug 8;8(8):e021222. Abstract
submitted by kickingbird at Aug, 16, 2018 from BMJ Open. 2018 Aug 8;8(8):e021222 (via https://www.ncbi.nlm.nih.gov/pubmed/30093515)
OBJECTIVES: Studies exploring vaccination rates among haematopoietic stem cell transplant (HSCT) recipients have focused on physician factors that limit uptake. Understanding the patient factors that determine ... Per Eriksson, etc.,al. Characterization of avian influenza virus attachment patterns to human and pig tissues. Scientific Reportsvolume 8, Article number: 12215. Abstract
submitted by kickingbird at Aug, 16, 2018 from Scientific Reportsvolume 8, Article number: 12215 (via https://www.nature.com/articles/s41598-018-29578-1)
Wild birds of Anseriformes and Charadriiformes are natural reservoirs of influenza A viruses (IAVs). Occasionally, IAVs transmit and adapt to mammalian hosts, and are maintained as epidemic strains in ... Maier HE, Lopez R, Sanchez N, Ng S, et al. Obesity Increases the Duration of Influenza A Virus Shedding in Adults. J Infect Dis 2018 Aug 2.. Abstract
submitted by kickingbird at Aug, 13, 2018 from J Infect Dis 2018 Aug 2. (via https://www.ncbi.nlm.nih.gov/m/pubmed/30085119/)
Epidemiologic studies indicate that obesity increases the risk of severe complications and death from influenza virus infections, especially in elderly individuals. This work investigates the effect of ... Brodskaia AV, etc.,al. Inhibition of influenza A virus by mixed siRNAs, targeting the PA, NP, and NS genes, delivered by hybrid microcarriers. Antiviral Res. 2018 Aug 6. pii: S0166-3542(17)3073. Abstract
submitted by kickingbird at Aug, 11, 2018 from Antiviral Res. 2018 Aug 6. pii: S0166-3542(17)3073 (via https://www.ncbi.nlm.nih.gov/pubmed/30092251)
In the present study, a highly effective carrier system has been developed for the delivery of antiviral siRNA mixtures. The developed hybrid microcarriers, made of biodegradable polymers and SiO2 nanostructures, ... Kuenstling TE, Sambol AR, Hinrichs SH. Oligomerization of bacterially expressed H1N1 recombinant hemagglutinin contributes to protection against viral challenge. Sci Rep. 2018 Aug 7;8(1):11856. Abstract
submitted by kickingbird at Aug, 11, 2018 from Sci Rep. 2018 Aug 7;8(1):11856 (via https://www.ncbi.nlm.nih.gov/pubmed/30087372)
Vaccination is the most effective intervention to prevent influenza and control the spread of the virus. Alternatives are needed to the traditional egg-based vaccine strategy for a more rapid response ... Furusawa Y, Yamada S, Kawaoka Y. Host Factor Nucleoporin 93 Is Involved in the Nuclear Export of Influenza Virus RNA. Front Microbiol. 2018 Jul 24;9:1675. Abstract
submitted by kickingbird at Aug, 11, 2018 from Front Microbiol. 2018 Jul 24;9:1675 (via https://www.ncbi.nlm.nih.gov/pubmed/30087672)
Influenza virus replication relies on the functions of host factors. In our previous study, we identified host factors involved in virus replication and began analyses of their roles in this process. In ... Fox A, Quinn KM, Subbarao K. Extending the Breadth of Influenza Vaccines: Status and Prospects for a Universal Vaccine. Drugs. 2018 Aug 7. doi: 10.1007/s40265-018-0958-7. Abstract
submitted by kickingbird at Aug, 11, 2018 from Drugs. 2018 Aug 7. doi: 10.1007/s40265-018-0958-7 (via https://www.ncbi.nlm.nih.gov/pubmed/30088204)
Despite the widespread use of seasonal influenza vaccines, there is urgent need for a universal influenza vaccine to provide broad, long-term protection. A number of factors underpin this urgency, including ... Du W, Dai M, Li Z, Boons GJ, Peeters B, van K. Substrate binding by the 2nd sialic acid-binding site of influenza A virus N1 neuraminidase contributes to enzymatic activity. J Virol. 2018 Aug 8.. Abstract
submitted by kickingbird at Aug, 11, 2018 from J Virol. 2018 Aug 8. (via https://www.ncbi.nlm.nih.gov/pubmed/30089692)
The influenza A virus (IAV) neuraminidase (NA) protein plays an essential role in the release of virus particles from cells and decoy receptors. The NA enzymatic activity presumably needs to match the ... Zhao M, etc.,al. Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses. MBio. 2018 Aug 7;9(4).. Abstract
submitted by kickingbird at Aug, 11, 2018 from MBio. 2018 Aug 7;9(4). (via https://www.ncbi.nlm.nih.gov/pubmed/30087171)
Against a backdrop of seasonal influenza virus epidemics, emerging avian influenza viruses (AIVs) occasionally jump from birds to humans, posing a public health risk, especially with the recent sharp increase ... Lambertz RLO, Pippel J, Gerhauser I, Kollmus H. Exchange of amino acids in the H1-haemagglutinin to H3 residues is required for efficient influenza A virus replication and pathology in Tmprss2 knock-out mice. J Gen Virol. 2018 Aug 6.. Abstract
submitted by kickingbird at Aug, 11, 2018 from J Gen Virol. 2018 Aug 6. (via https://www.ncbi.nlm.nih.gov/pubmed/30084768)
The haemagglutinin (HA) of H1N1 and H3N2 influenza A virus (IAV) subtypes has to be activated by host proteases. Previous studies showed that H1N1 virus cannot replicate efficiently in Tmprss2-/- knock-out ... Loy H, Kuok DIT, Hui KPY, Choi MHL, Yuen W. Therapeutic implications of human umbilical cord mesenchymal stromal cells in attenuating influenza A/H5N1-associated acute lung injury. J Infect Dis. 2018 Aug 2.. Abstract
submitted by kickingbird at Aug, 11, 2018 from J Infect Dis. 2018 Aug 2. (via https://www.ncbi.nlm.nih.gov/pubmed/30085072)
Background: Highly pathogenic avian influenza viruses can cause severe forms of acute lung injury (ALI) in humans, where pulmonary flooding leads to respiratory failure. Therapeutic benefits of bone-marrow ... Song L, Xiong D, Hu M, Jiao X, Pan Z. Enhanced Th1/Th2 mixed immune responses elicited by polyethyleneimine adjuvanted influenza A (H7N9) antigen HA1-2 in chickens. Poult Sci. 2018 Aug 1. Abstract
submitted by kickingbird at Aug, 11, 2018 from Poult Sci. 2018 Aug 1 (via https://www.ncbi.nlm.nih.gov/pubmed/30085299)
Influenza A (H7N9) viruses have caused severe human infections and deaths every year in China since 2013. To reduce the risk of human infection and prevent a new influenza pandemic, there is a pressing ... Grech-Angelini S, Hervé S, Rose N, Barbier N. Serological survey of influenza A viruses in domestic and wild Suidae in Corsica (France), a Mediterranean island environment.. Prev Vet Med. 2018 Sep 1;157:94-98.. Abstract
submitted by kickingbird at Aug, 11, 2018 from Prev Vet Med. 2018 Sep 1;157:94-98. (via https://www.ncbi.nlm.nih.gov/pubmed/30086855)
Corsica is a mountainous French island in the north-western Mediterranean Sea. It is a rural area, where pig farming is a major economic activity. Although no acute respiratory outbreaks due to swine influenza ... Kuchipudi SV, Nissly RH. Novel Flu Viruses in Bats and Cattle:. Vet Sci. 2018 Aug 6;5(3). Abstract
submitted by kickingbird at Aug, 11, 2018 from Vet Sci. 2018 Aug 6;5(3) (via https://www.ncbi.nlm.nih.gov/pubmed/30082582)
Influenza viruses are among the major infectious disease threats of animal and human health. This review examines the recent discovery of novel influenza viruses in bats and cattle, the evolving complexity ... Ferro S, Gitto R, Buemi MR, Karamanou S. Identification of influenza PA-Nter endonuclease inhibitors using pharmacophore- and docking-based virtual screening. Bioorg Med Chem. 2018 Jul 27.. Abstract
submitted by kickingbird at Aug, 11, 2018 from Bioorg Med Chem. 2018 Jul 27. (via https://www.ncbi.nlm.nih.gov/pubmed/30082105)
Searching for new antiviral agents, we focused our interest on the influenza PA-Nter endonuclease. Therefore, we developed a three-dimensional pharmacophore model which contains the binding features addressed ... Lyons DM, Lauring AS. Mutation and Epistasis in Influenza Virus Evolution. Viruses. 2018 Aug 3;10(8).. Abstract
submitted by kickingbird at Aug, 11, 2018 from Viruses. 2018 Aug 3;10(8). (via https://www.ncbi.nlm.nih.gov/pubmed/30081492)
Influenza remains a persistent public health challenge, because the rapid evolution of influenza viruses has led to marginal vaccine efficacy, antiviral resistance, and the annual emergence of novel strains. ... Liu J, Ren Z, Wang H, Zhao Y, Wilker PR, Yu Z. Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses. Int Immunopharmacol. 2018 Aug 3;63:119-128.. Abstract
submitted by kickingbird at Aug, 8, 2018 from Int Immunopharmacol. 2018 Aug 3;63:119-128. (via https://www.ncbi.nlm.nih.gov/pubmed/30081250)
Influenza viruses cause significant morbidity and mortality and pose a substantial threat to public health. Vaccination represents the principle means of preventing influenza virus infection. Current vaccine ... 5328 items, 20/Page, Page[142/267][|<<] [|<] [141] [142] [143] [144] [145] [146] [147] [148] [149] [150] [>|] [>>|] |
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