Karen K. Wong, etc.,al. Transmissibility of Variant Influenza From Swine to Humans: A Modeling Approach. Clin Infect Dis. (2013) 57 (suppl 1): S16-S22 doi. Abstract
submitted by kickingbird at Jul, 12, 2013 from Clin Infect Dis. (2013) 57 (suppl 1): S16-S22 doi (via http://cid.oxfordjournals.org/content/57/suppl_1/S16.abstrac)
Background.Respiratory illness was reported among humans and swine at an agricultural fair in 2011; 3 human infections with an influenza A(H3N2) variant (H3N2v) virus were confirmed. Using epidemiologic ... Manoj Gambhir,etc.,al. Multiple Contributory Factors to the Age Distribution of Disease Cases: A Modeling Study in the Context of Influenza A(H3N2v). Clin Infect Dis. (2013) 57 (suppl 1): S23-S27 doi. Abstract
submitted by kickingbird at Jul, 12, 2013 from Clin Infect Dis. (2013) 57 (suppl 1): S23-S27 doi (via http://cid.oxfordjournals.org/content/57/suppl_1/S23.abstrac)
Background. In late 2011 and early 2012, 13 cases of human influenza resulted from infection with a novel triple reassortant swine-origin influenza virus, influenza A (H3N2) variant. This variant was notable ... JA Belser, etc.,al. Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice. Nature Year published: (2013) DOI: doi:10.1038/nat. Abstract
submitted by kickingbird at Jul, 12, 2013 from Nature Year published: (2013) DOI: doi:10.1038/nat (via http://www.nature.com/nature/journal/vaop/ncurrent/full/natu)
On 29 March 2013, the Chinese Center for Disease Control and Prevention confirmed the first reported case of human infection with an avian influenza A(H7N9) virus1. The recent human infections with H7N9 ... Yinhua Huang, etc.,al. The duck genome and transcriptome provide insight into an avian influenza virus reservoir species. Nature Genetics 45, 776–783 (2013). Abstract
submitted by kickingbird at Jul, 11, 2013 from Nature Genetics 45, 776–783 (2013) (via http://www.nature.com/ng/journal/v45/n7/full/ng.2657.html)
The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. ... Andrew B. Reeves, etc.,al. GENOMIC ANALYSIS OF AVIAN INFLUENZA VIRUSES FROM WATERFOWL IN WESTERN ALASKA, USA. jwildlifedis July 1, 2013 vol. 49 no. 3 600-61. Abstract
submitted by kickingbird at Jul, 11, 2013 from jwildlifedis July 1, 2013 vol. 49 no. 3 600-61 (via http://www.jwildlifedis.org/content/49/3/600.full)
The Yukon-Kuskokwim Delta (Y-K Delta) in western Alaska is an immense and important breeding ground for waterfowl. Migratory birds from the Pacific Americas, Central Pacific, and East Asian-Australasian ... Girard MP, Tam JS, Pervikov Y, Katz JM.. Report on the first WHO integrated meeting on development and clinical trials of influenza vaccines that induce broadly protective and long-lasting immune responses: Hong Kong SAR, China, 24-26 Januar. Vaccine. 2013 Jun 26.. Abstract
submitted by kickingbird at Jul, 9, 2013 from Vaccine. 2013 Jun 26. (via http://www.ncbi.nlm.nih.gov/pubmed/23810374)
On January 24-26, 2013, the World Health Organization convened the first integrated meeting on "The development and clinical trials of vaccines that induce broadly protective and long-lasting immune responses" ... KREIJTZ JH, Kroeze EV, Stittelaar KJ, de Waal L, e. Low pathogenic avian influenza A(H7N9) virus causes high mortality in ferrets upon intratracheal challenge: A model to study intervention strategies. Vaccine. 2013 Jun 28. pii: S0264-410X(13)00880. Abstract
submitted by kickingbird at Jul, 9, 2013 from Vaccine. 2013 Jun 28. pii: S0264-410X(13)00880 (via http://www.ncbi.nlm.nih.gov/pubmed/23816392)
Infections with low pathogenic avian influenza (LPAI) A(H7N9) viruses have caused more than 100 hospitalized human cases of severe influenza in China since February 2013 with a case fatality rate exceeding ... SALATHE M, Freifeld CC, Mekaru SR, Tomasulo AF, et. Influenza A (H7N9) and the Importance of Digital Epidemiology. N Engl J Med. 2013 Jul 3. Abstract
submitted by kickingbird at Jul, 9, 2013 from N Engl J Med. 2013 Jul 3 (via http://www.nejm.org/doi/full/10.1056/NEJMp1307752)
On March 31, 2013, Chinese health officials notified the World Health Organization of three cases of human infection with novel influenza A (H7N9). Since then, 132 people have been infected, 37 of them ... LI Q, Qi J, Wu Y, Kiyota H, et al. Functional and structural analysis of influenza neuraminidase N3 offers further insight into the mechanisms of oseltamivir-resistance. J Virol. 2013 Jul 3. Abstract
submitted by kickingbird at Jul, 9, 2013 from J Virol. 2013 Jul 3 (via http://www.ncbi.nlm.nih.gov/pubmed/23824808)
The influenza neuraminidase H274Y substitution is a highly prevalent amino acid substitution associated with resistance to the most heavily used influenza drug, oseltamivir. Previous structural studies ... MAGADAN JG, Khurana S, Das SR, Frank GM, et al. Influenza A Virus Hemagglutinin Trimerization Completes Monomer Folding and Antigenicity. J Virol. 2013 Jul 3. Abstract
submitted by kickingbird at Jul, 9, 2013 from J Virol. 2013 Jul 3 (via http://www.ncbi.nlm.nih.gov/pubmed/23824811)
Influenza A virus (IAV) remains an important human pathogen largely due to antigenic drift: the rapid emergence of antibody escape mutants which precludes durable vaccination. The most potent neutralizing ... LOVING CL, Lager KM, Vincent AL, Brockmeier SL, et. Efficacy of inactivated and live-attenuated influenza virus vaccines in pigs against infection and transmission of emerging H3N2 similar to the 2011-2012 H3N2v. J Virol. 2013 Jul 3. Abstract
submitted by kickingbird at Jul, 9, 2013 from J Virol. 2013 Jul 3 (via http://www.ncbi.nlm.nih.gov/pubmed/23824815)
Vaccines provide a primary means to limit disease but may not be effective at blocking infection and pathogen transmission. The objective of the current study was to evaluate the efficacy of commercial ... LI Y, Bostick DL, Sullivan CB, Myers JL, et al. Single Hemagglutinin Mutations that Alter Both Antigenicity and Receptor Binding Avidity Influence Influenza Virus Antigenic Clustering. J Virol. 2013 Jul 3.. Abstract
submitted by kickingbird at Jul, 9, 2013 from J Virol. 2013 Jul 3. (via http://www.ncbi.nlm.nih.gov/pubmed/23824816)
The hemagglutination-inhibition (HAI) assay is the primary measurement used for identifying antigenically novel influenza strains. HAI assays measure the amount of reference sera required to prevent virus ... ZARAKET H, Bridges OA, Duan S, Baranovich T, et al. Increased acid stability of the hemagglutinin protein enhances H5N1 influenza virus growth in the upper respiratory tract but is insufficient for transmission in ferrets. J Virol. 2013 Jul 3. Abstract
submitted by kickingbird at Jul, 9, 2013 from J Virol. 2013 Jul 3 (via http://www.ncbi.nlm.nih.gov/pubmed/23824818)
Influenza virus entry is mediated by the acidic pH-induced activation of hemagglutinin (HA) protein. Here, we investigated how a decrease in HA activation pH (an increase in acid stability) influences ... HARDER TC, Grosse Beilage E, Lange E, Meiners C, e. Expanded co-circulation of stable subtypes, emerging lineages and new sporadic reassortants of porcine influenza viruses in swine populations in Northwest Germany. J Virol. 2013 Jul 3.. Abstract
submitted by kickingbird at Jul, 9, 2013 from J Virol. 2013 Jul 3. (via http://www.ncbi.nlm.nih.gov/pubmed/23824819)
The emergence of the human 2009 pandemic H1N1 (H1N1pdm) from swine populations re-focused public and scientific attention towards swine as an important source of influenza A viruses bearing zoonotic potential. ... STEVAERT A, Dallocchio R, Dessi A, Pala N, et al. Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease. J Virol. 2013 Jul 3. Abstract
submitted by kickingbird at Jul, 9, 2013 from J Virol. 2013 Jul 3 (via http://www.ncbi.nlm.nih.gov/pubmed/23824822)
The influenza virus PA endonuclease, which cleaves capped host pre-mRNAs to initiate synthesis of viral mRNA, is a prime target for antiviral therapy. The diketo acid compound L-742,001 was previously ... JEGASKANDA S, Laurie KL, Amarasena TH, Winnall WR,. Age-associated cross-reactive ADCC toward 2009-pandemic influenza. J Infect Dis. 2013 Jun 28.. Abstract
submitted by kickingbird at Jul, 9, 2013 from J Infect Dis. 2013 Jun 28. (via http://www.ncbi.nlm.nih.gov/pubmed/23812238)
Background.?During the 2009 H1N1 influenza pandemic older individuals were partially protected from severe disease. It is not known whether pre-existing antibodies with effector functions such as antibody-dependent ... BRANDES M, Klauschen F, Kuchen S, Germain RN, et a. A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection. Cell. 2013;154:197-212. Abstract
submitted by kickingbird at Jul, 9, 2013 from Cell. 2013;154:197-212 (via http://www.ncbi.nlm.nih.gov/pubmed/23827683)
For acutely lethal influenza infections, the relative pathogenic contributions of direct viral damage to lung epithelium versus dysregulated immunity remain unresolved. Here, we take a top-down systems ... TAM VC, Quehenberger O, Oshansky CM, Suen R, et al. Lipidomic Profiling of Influenza Infection Identifies Mediators that Induce and Resolve Inflammation. Cell. 2013;154:213-27. Abstract
submitted by kickingbird at Jul, 9, 2013 from Cell. 2013;154:213-27 (via http://www.ncbi.nlm.nih.gov/pubmed/23827684)
Bioactive lipid mediators play a crucial role in the induction and resolution of inflammation. To elucidate their involvement during influenza infection, liquid chromatography/mass spectrometry lipidomic ... HAASBACH E, Reiling SJ, Ehrhardt C, Droebner K, et. The NF-kappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus. Antiviral Res. 2013 Jun 27. pii: S0166-3542(13)001. Abstract
submitted by kickingbird at Jul, 9, 2013 from Antiviral Res. 2013 Jun 27. pii: S0166-3542(13)001 (via http://www.ncbi.nlm.nih.gov/pubmed/23811282)
The appearance of pandemic H1N1 and highly pathogenic avian H5N1 viruses in humans as well as the emergence of seasonal H1N1 variants resistant against neuraminidase inhibitors highlight the urgent need ... KIM MC, Lee JS, Kwon YM, Eunju O, et al. Multiple heterologous M2 extracellular domains presented on virus-like particles confer broader and stronger M2 immunity than live influenza A virus infection. Antiviral Res. 2013 Jun 27. pii: S0166-3542(13)001. Abstract
submitted by kickingbird at Jul, 9, 2013 from Antiviral Res. 2013 Jun 27. pii: S0166-3542(13)001 (via http://www.ncbi.nlm.nih.gov/pubmed/23811283)
The influenza M2 ectodomain (M2e) is poorly immunogenic and has some amino acid changes among isolates from different host species. We expressed a tandem repeat construct of heterologous M2e sequences ... 8178 items, 20/Page, Page[299/409][|<<] [|<] [291] [292] [293] [294] [295] [296] [297] [298] [299] [300] [>|] [>>|] |
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