DE DONNO A, Idolo A, Quattrocchi M, Zizza A, et al. Surveillance of human influenza A(H3N2) virus from 1999 to 2009 in southern Italy. Epidemiol Infect. 2013 Aug 22:1-7.. Abstract
submitted by kickingbird at Aug, 26, 2013 from Epidemiol Infect. 2013 Aug 22:1-7. (via http://www.ncbi.nlm.nih.gov/pubmed/23967903)
SUMMARY The aim of this study was to evaluate the presence of influenza virus co-infections in humans and changes in the genetic variability of A(H3N2) virus strains in southern Italy from 1999 to 2009. ... WAUGH T, Ching JC, Zhou Y, Loewen ME, et al. Influenza A virus (H1N1) increases airway epithelial cell secretion by up-regulation of potassium channel KCNN4.. Biochem Biophys Res Commun. 2013 Aug 13. pii: S000. Abstract
submitted by kickingbird at Aug, 26, 2013 from Biochem Biophys Res Commun. 2013 Aug 13. pii: S000 (via http://www.ncbi.nlm.nih.gov/pubmed/23954634)
Influenza infects the epithelial cells lining the airways. Normally epithelial cells move solutes through ion channels to create the osmotic drive to hydrate the airways. Viral alteration of this process ... Tsan-Yuk Lam, T. et al. The genesis and source of the H7N9 influenza viruses causing human infections in China. Nature (2013) doi:10.1038/nature12515. Abstract
submitted by kickingbird at Aug, 22, 2013 from Nature (2013) doi:10.1038/nature12515 (via http://www.nature.com/nature/journal/vaop/ncurrent/full/natu)
A novel H7N9 influenza A virus first detected in March 2013 has since caused more than 130 human infections in China, resulting in 40 deaths. Preliminary analyses suggest that the virus is a reassortant of H7, N9 and H9N2 avian influenza viruses, and carries some amino acids associated with mammalian receptor binding, raising concerns of a new pandemic. However, neither the source populations of the H7N9 outbreak lineage nor the conditions for its genesis are fully known. Using a combination of active surveillance, screening of virus archives, and evolutionary analyses, here we show that H7 viruses probably transferred from domestic duck to chicken populations in China on at least two independent occasions. We show that the H7 viruses subsequently reassorted with enzootic H9N2 viruses to generate the H7N9 outbreak lineage, and a related previously unrecognized H7N7 lineage. The H7N9 outbreak lineage has spread over a large geographic region and is prevalent in chickens at live poultry markets, which are thought to be the immediate source of human infections. Whether the H7N9 outbreak lineage has, or will, become enzootic in China and neighbouring regions requires further investigation. The discovery here of a related H7N7 influenza virus in chickens that has the ability to infect mammals experimentally, suggests that H7 viruses may pose threats beyond the current outbreak. The continuing prevalence of H7 viruses in poultry could lead to the generation of highly pathogenic variants and further sporadic human infections, with a continued risk of the virus acquiring human-to-human transmissibility. REDFORD PS, Mayer-Barber KD, McNab FW, Stavropoulo. Influenza A virus impairs control of Mycobacterium tuberculosis co-infection through a Type I Interferon receptor dependent pathway. J Infect Dis. 2013 Aug 9. Abstract
submitted by kickingbird at Aug, 20, 2013 from J Infect Dis. 2013 Aug 9 (via http://www.ncbi.nlm.nih.gov/pubmed/23935205)
Influenza, followed by severe acute bacterial pneumonia, is a major cause of mortality worldwide. Several mechanisms account for this enhanced susceptibility, including increased production of Type I IFN. ... HARA K, Nakazono Y, Kashiwagi T, Hamada N, et al. Co-incorporation of the PB2 and PA polymerase subunits from human H3N2 influenza virus is a critical determinant of the replication of reassortant ribonucleoprotein complexes. J Gen Virol. 2013 Aug 12.. Abstract
submitted by kickingbird at Aug, 20, 2013 from J Gen Virol. 2013 Aug 12. (via http://www.ncbi.nlm.nih.gov/pubmed/23939981)
The influenza virus RNA polymerase, composed of the PB1, PB2, and PA subunits, has a potential role in influencing genetic reassortment. Recent studies on the reassortment of human H3N2 strains suggest ... SHENG Z, Ran Z, Wang D, Hoppe AD, et al. Genomic and evolutionary characterization of a novel influenza-C-like virus from swine. Arch Virol. 2013 Aug 13.. Abstract
submitted by kickingbird at Aug, 20, 2013 from Arch Virol. 2013 Aug 13. (via http://www.ncbi.nlm.nih.gov/pubmed/23942954)
We recently described the isolation of a novel influenza virus from swine exhibiting respiratory disease in the United States that is distantly related to human influenza C virus. Based on genetic, biochemical ... YODSHEEWAN R, Maneewatch S, Srimanote P, Thueng-In. Human monoclonal ScFv specific to NS1 protein inhibits replication of influenza viruses across types and subtypes. Antiviral Res. 2013 Aug 6. pii:. Abstract
submitted by kickingbird at Aug, 20, 2013 from Antiviral Res. 2013 Aug 6. pii: (via http://www.ncbi.nlm.nih.gov/pubmed/23928258)
Currently, there is a need of new anti-influenza agents that target influenza virus proteins other than ion channel M2 and neuraminidase. Non-structural protein-1 (NS1) is a highly conserved multifunctional ... NGUYEN YT, Graitcer SB, Nguyen TH, Tran DN, et al. National surveillance for influenza and influenza-like illness in Vietnam, 2006-2010. Vaccine. 2013 Jul 30. pii: S0264-410X(13)00942. Abstract
submitted by kickingbird at Aug, 11, 2013 from Vaccine. 2013 Jul 30. pii: S0264-410X(13)00942 (via http://www.ncbi.nlm.nih.gov/pubmed/23911781)
Influenza virus infections result in considerable morbidity and mortality both in the temperate and tropical world. Influenza surveillance over multiple years is important to determine the impact and epidemiology ... PANG IK, Pillai PS, Iwasaki A. Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I.. Proc Natl Acad Sci U S A. 2013 Aug 5.. Abstract
submitted by kickingbird at Aug, 11, 2013 from Proc Natl Acad Sci U S A. 2013 Aug 5. (via http://www.ncbi.nlm.nih.gov/pubmed/23918369)
Induction of a proinflammatory response is the hallmark of host innate defense against invading pathogens. Host recognition of influenza A virus (IAV) infection relies on pattern-recognition receptors, ... BOUSSE T, Shore DA, Goldsmith CS, Hossain MJ, et a. Quantitation of influenza virus using field flow fractionation and multi-angle light scattering for quantifying influenza A particles. J Virol Methods. 2013 Jul 31.. Abstract
submitted by kickingbird at Aug, 11, 2013 from J Virol Methods. 2013 Jul 31. (via http://www.ncbi.nlm.nih.gov/pubmed/23916678)
Recent advances in instrumentation and data analysis in field flow fractionation and multi-angle light scattering (FFF-MALS) have enabled greater use of this technique to characterize and quantitate viruses. ... HU J, Hu Z, Mo Y, Wu Q, et al. The PA and HA Genes-Mediated High Viral Load and Intense Innate Immune Response in the Brain Contribute to the High Pathogenicity of H5N1 Avian Influenza Virus in Mallard Ducks. J Virol. 2013 Aug 7. Abstract
submitted by kickingbird at Aug, 11, 2013 from J Virol. 2013 Aug 7 (via http://www.ncbi.nlm.nih.gov/pubmed/23926340)
Most highly pathogenic avian influenza A viruses only cause mild clinical signs in ducks serving as an important natural reservoir of influenza A viruses. However, we isolated two H5N1 viruses that are ... MYERS JL, Wetzel KS, Linderman SL, Li Y, et al. Compensatory hemagglutinin mutations alter antigenic properties of influenza viruses. J Virol. 2013 Aug 7. Abstract
submitted by kickingbird at Aug, 11, 2013 from J Virol. 2013 Aug 7 (via http://www.ncbi.nlm.nih.gov/pubmed/23926344)
Influenza viruses routinely acquire mutations in antigenic sites on the globular head of the hemagglutinin (HA) protein. Since these antigenic sites are near the receptor binding pocket of HA, many antigenic ... GOTO H, Muramoto Y, Noda T, Kawaoka Y, et al. The genome packaging signal of the influenza A virus genome comprises a genome incorporation signal and a genome bundling signal. J Virol. 2013 Aug 7. Abstract
submitted by kickingbird at Aug, 11, 2013 from J Virol. 2013 Aug 7 (via http://www.ncbi.nlm.nih.gov/pubmed/23926345)
The influenza A virus genome comprises eight single-stranded negative-sense RNA segments (vRNAs). All eight vRNAs are selectively packaged into each progeny virion via so-called segment-specific genome ... LOHRMANN F, Dijkman R, Stertz S, Thiel V, et al. Emergence of a C-terminal seven amino acid elongation of NS1 around 1950 conferred a minor growth advantage to former seasonal influenza A viruses. J Virol. 2013 Aug 7.. Abstract
submitted by kickingbird at Aug, 11, 2013 from J Virol. 2013 Aug 7. (via http://www.ncbi.nlm.nih.gov/pubmed/23926347)
Influenza A viruses circulating in humans from ～1950 to ～1987 featured a non-structural (NS1) protein with a C-terminal extension of seven amino acids. The biological significance of this NS1 elongation ... NG S, Fang VJ, Ip DK, Chan KH, et al. Estimation of the association between antibody titers and protection against confirmed influenza virus infection in children. J Infect Dis. 2013 Aug 1.. Abstract
submitted by kickingbird at Aug, 11, 2013 from J Infect Dis. 2013 Aug 1. (via http://www.ncbi.nlm.nih.gov/pubmed/23908481)
Antibody titers measured by hemagglutination inhibition (HAI) correlate with protection against influenza virus infection, and are used to specify criteria for vaccine licensure. In a randomized controlled ... Xian Qi, etc.,al. Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation. BMJ 2013;347:f4752. Abstract
submitted by kickingbird at Aug, 9, 2013 from BMJ 2013;347:f4752 (via http://www.bmj.com/content/347/bmj.f4752)
Abstract
Objective To determine whether the novel avian influenza H7N9 virus can transmit from person to person and its efficiency.
Design Epidemiological investigations conducted after a family cluster ... KOHIO HP, Adamson AL. Glycolytic control of vacuolar-type ATPase activity: A mechanism to regulate influenza viral infection. Virology. 2013 Jul 19. Abstract
submitted by kickingbird at Jul, 30, 2013 from Virology. 2013 Jul 19 (via http://www.ncbi.nlm.nih.gov/pubmed/23876457)
As new influenza virus strains emerge, finding new mechanisms to control infection is imperative. In this study, we found that we could control influenza infection of mammalian cells by altering the level ... SZURGOT I, Szolajska E, Laurin D, Lambrecht B, et. Self-adjuvanting influenza candidate vaccine presenting epitopes for cell-mediated immunity on a proteinaceous multivalent nanoplatform. Vaccine. 2013 Jul 20. Abstract
submitted by kickingbird at Jul, 30, 2013 from Vaccine. 2013 Jul 20 (via http://www.ncbi.nlm.nih.gov/pubmed/23880363)
We exploit the features of a virus-like particle, adenoviral dodecahedron (Ad Dd), for engineering a multivalent vaccination platform carrying influenza epitopes for cell-mediated immunity. The delivery ... HERTZ T, Oshansky CM, Roddam PL, Devincenzo JP, et. HLA targeting efficiency correlates with human T-cell response magnitude and with mortality from influenza A infection. Proc Natl Acad Sci U S A. 2013 Jul 22. Abstract
submitted by kickingbird at Jul, 30, 2013 from Proc Natl Acad Sci U S A. 2013 Jul 22 (via http://www.ncbi.nlm.nih.gov/pubmed/23878211)
Experimental and computational evidence suggests that HLAs preferentially bind conserved regions of viral proteins, a concept we term "targeting efficiency," and that this preference may provide improved ... SHCHERBIK S, Sergent SB, Davis WG, Shu B, et al. Application of real time RT-PCR for the genetic homogeneity and stability tests of the seed candidates for live attenuated influenza vaccine production. J Virol Methods. 2013 Jul 18. pii: S0166-0934. Abstract
submitted by kickingbird at Jul, 30, 2013 from J Virol Methods. 2013 Jul 18. pii: S0166-0934 (via http://www.ncbi.nlm.nih.gov/pubmed/23872266)
Development and improvement of quality control tests for live attenuated vaccines are a high priority because of safety concerns. Live Attenuated Influenza Vaccine (LAIV) viruses are 6:2 reassortants containing ... 7523 items, 20/Page, Page[264/377][|<<] [|<] [261] [262] [263] [264] [265] [266] [267] [268] [269] [270] [>|] [>>|] |
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