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2024-4-20 2:33:00
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FAN RL, Valkenburg SA, Wong CK, Li OT, et al. Generation of live attenuated influenza virus using codon usage bias. J Virol. 2015 Aug 12. pii: JVI.01443-15..  Abstract  
submitted by kickingbird at Aug, 16, 2015 from J Virol. 2015 Aug 12. pii: JVI.01443-15. (via http://www.ncbi.nlm.nih.gov/pubmed/26269186)
Seasonal influenza epidemics and occasional pandemics threaten public health worldwide. New alternative strategies for generating recombinant viruses of vaccine potential are needed. Interestingly, influenza ...

WANG W, DeFeo CJ, Alvarado E, Vassell R, et al. Intermonomer Interactions in Hemagglutinin subunits HA1 and HA2 Affecting Hemagglutinin Stability and Influenza Virus Infectivity. J Virol. 2015 Aug 12. pii: JVI.00939-15.  Abstract  
submitted by kickingbird at Aug, 16, 2015 from J Virol. 2015 Aug 12. pii: JVI.00939-15 (via http://www.ncbi.nlm.nih.gov/pubmed/26269180)
Influenza virus hemagglutinin (HA) mediates virus entry by binding to cell surface receptors and fusing the viral and endosomal membranes following uptake by endocytosis. The acidic environment of endosomes ...

TURKINGTON HL, Juozapaitis M, Kerry PS, Aydillo T,. Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity. J Virol. 2015 Aug 5. pii: JVI.01430-15.  Abstract  
submitted by kickingbird at Aug, 10, 2015 from J Virol. 2015 Aug 5. pii: JVI.01430-15 (via http://www.ncbi.nlm.nih.gov/pubmed/26246567)
We demonstrate that novel bat HL17NL10 and HL18NL11 influenza virus NS1 proteins are effective interferon-antagonists, but do not block general host gene expression. Solving the RNA-binding domain structures ...

DIEDERICH S, Berhane Y, Embury-Hyatt C, Hisanaga T. Hemagglutinin-Neuraminidase Balance Influences the Virulence Phenotype of a Recombinant H5N3 Influenza A Virus Possessing a Polybasic HA0 Cleavage Site. J Virol. 2015 Aug 5. pii: JVI.01238-15..  Abstract  
submitted by kickingbird at Aug, 10, 2015 from J Virol. 2015 Aug 5. pii: JVI.01238-15. (via http://www.ncbi.nlm.nih.gov/pubmed/26246579)
Although a polybasic HA0 cleavage site is considered the dominant virulence determinant for highly pathogenic avian influenza (HPAI) H5 and H7 viruses, naturally occurring virus isolates possessing a polybasic ...

Diaz A, Enomoto S, Romagosa A, Sreevatsan S, Nelso. Genome plasticity of triple reassortant H1N1 influenza A virus during infection of vaccinated pigs. J Gen Virol. 2015 Aug 5. doi: 10.1099/jgv.  Abstract  
submitted by kickingbird at Aug, 10, 2015 from J Gen Virol. 2015 Aug 5. doi: 10.1099/jgv (via http://www.ncbi.nlm.nih.gov/pubmed/26251306)
To gain insights into the evolution of influenza A viruses (IAVs) during infection of vaccinated pigs, we experimentally infected a 3 week-old naive pig with a triple reassortant H1N1 IAV and placed him ...

Farrell PC, Hunter C, Truong B, Bunning M. Control of highly pathogenic avian influenza in Quang Tri province, Vietnam: voices from the human animal interface. Rural and Remote Health 15: 3044. (Online) 2015.  Abstract  
submitted by kickingbird at Aug, 7, 2015 from Rural and Remote Health 15: 3044. (Online) 2015 (via http://www.rrh.org.au/articles/subviewnew.asp?ArticleID=3044)
Highly pathogenic avian influenza (HPAI) is caused by the haemagglutinin 5, neuraminidase 1 (H5N1) influenza A virus. Around 80% of households in rural Vietnam raise poultry, which provides food security ...

Liu R, Leung RK-k, Chen T, Zhang X, Chen F, Chen S. The Effectiveness of Age-Specific Isolation Policies on Epidemics of Influenza A (H1N1) in a Large City in Central South China. PLoS ONE 10(7): e0132588. doi:10.1371/journal.pone.  Abstract  
submitted by kickingbird at Aug, 7, 2015 from PLoS ONE 10(7): e0132588. doi:10.1371/journal.pone (via http://journals.plos.org/plosone/article?id=10.1371/journal.)
During the early stage of a pandemic, isolation is the most effective means of controlling transmission. However, the effectiveness of age-specific isolation policies is not clear; especially little information ...

MI Nelson, DE Wentworth, SR Das. Evolutionary dynamics of influenza A viruses in US exhibition swine. J Infect Dis. (2015) doi:.  Abstract  
submitted by kickingbird at Aug, 7, 2015 from J Infect Dis. (2015) doi: (via http://jid.oxfordjournals.org/content/early/2015/08/03/infdi)
The role of exhibition swine in influenza A virus (IAVs) transmission was recently demonstrated by over 300 human infections of H3N2v viruses while attending agricultural fairs. Through active IAV surveillance ...

Leung YH, To MK, Lam TS, et al. Epidemiology of human influenza A(H7N9) infection in Hong Kong. J Microbiol Immunol Infect. 2015 Jun.  Abstract  
submitted by kickingbird at Aug, 5, 2015 from J Microbiol Immunol Infect. 2015 Jun (via http://www.e-jmii.com/article/S1684-1182(15)00772-0/fulltext)
Background/Purpose We conducted a case series study to review the epidemiology of human influenza A(H7N9) infection reported in Hong Kong. Methods We reviewed case records of confirmed human cases of ...

Yang ZF, Mok CK, Peiris JS, Zhong NS.. Human Infection with a Novel Avian Influenza A(H5N6) Virus. N Engl J Med 2015; 373:487-489.  Abstract  
submitted by kickingbird at Aug, 2, 2015 from N Engl J Med 2015; 373:487-489 (via http://www.nejm.org/doi/full/10.1056/NEJMc1502983)
Multiple reassortant strains of novel, highly pathogenic avian influenza A(H5) viruses in clade 2.3.4.4 have recently emerged and spread in Asia, Europe, and North America, giving rise to multiple subtypes ...

HARTMANN BM, Thakar J, Albrecht RA, Avey S, et al. Human dendritic cell response signatures distinguish 1918, pandemic and seasonal H1N1 influenza viruses. J Virol. 2015 Jul 29. pii: JVI.01523-15.  Abstract  
submitted by kickingbird at Aug, 2, 2015 from J Virol. 2015 Jul 29. pii: JVI.01523-15 (via http://www.ncbi.nlm.nih.gov/pubmed/26223639)
Influenza viruses continue to present global threats to human health. Antigenic drift and shift, genetic reassortment, and cross-species transmission generate new strains with differences in epidemiology ...

CHENG YH, Wang CH, You SH, Hsieh NH, et al. Assessing coughing-induced influenza droplet transmission and implications for infection risk control. Epidemiol Infect. 2015 Jul 27:1-13..  Abstract  
submitted by kickingbird at Aug, 2, 2015 from Epidemiol Infect. 2015 Jul 27:1-13. (via http://www.ncbi.nlm.nih.gov/pubmed/26211781)
Indoor transmission of respiratory droplets bearing influenza within humans poses high risks to respiratory function deterioration and death. Therefore, we aimed to develop a framework for quantifying ...

Wu H, Peng X, Peng X, Wu N.. Molecular characterization of a reassortant H11N9 subtype avian influenza virus isolated from a domestic duck in Eastern China. Arch Virol. 2015 Jul 28..  Abstract  
submitted by kickingbird at Aug, 2, 2015 from Arch Virol. 2015 Jul 28. (via http://www.ncbi.nlm.nih.gov/pubmed/26212362)
During surveillance for avian influenza viruses (AIVs) in live-poultry markets in Eastern China in 2013, an H11N9 AIV was isolated from a domestic duck. Phylogenetic analysis showed that this strain received ...

Joanna A. Pulit-Penaloza, Xiangjie Sun, Hannah M.. Pathogenesis and transmission of novel HPAI H5N2 and H5N8 avian influenza viruses in ferrets and mice. Journal of Virology.  Abstract  
submitted by kickingbird at Jul, 31, 2015 from Journal of Virology (via http://jvi.asm.org/content/early/2015/07/24/JVI.01438-15.abs)
A novel highly pathogenic avian influenza (HPAI) H5N8 virus, first detected in January 2014 in poultry and wild birds in South Korea, has spread throughout Asia and Europe, and caused outbreaks in Canada ...

Yang W, Cowling BJ, Lau EHY, Shaman J. Forecasting Influenza Epidemics in Hong Kong. PLoS Comput Biol 11(7): e1004383. doi:10.1371/jour.  Abstract  
submitted by kickingbird at Jul, 31, 2015 from PLoS Comput Biol 11(7): e1004383. doi:10.1371/jour (via http://journals.plos.org/ploscompbiol/article?id=10.1371/jou)
Recent advances in mathematical modeling and inference methodologies have enabled development of systems capable of forecasting seasonal influenza epidemics in temperate regions in real-time. However, ...

Wu, Y. et al.. A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus. Nature Communications.  Abstract  
submitted by kickingbird at Jul, 28, 2015 from Nature Communications (via http://www.nature.com/ncomms/2015/150721/ncomms8708/full/nco)
Effective annual influenza vaccination requires frequent changes in vaccine composition due to both antigenic shift for different subtype hemagglutinins (HAs) and antigenic drift in a particular HA. Here ...

MEDINA J, Boukhebza H, De Saint Jean A, Sodoyer R,. Optimization of influenza A vaccine virus by reverse genetic using chimeric HA and NA genes with an extended PR8 backbone. Vaccine. 2015 Jul 20. pii: S0264-410X(15)00981-0..  Abstract  
submitted by kickingbird at Jul, 27, 2015 from Vaccine. 2015 Jul 20. pii: S0264-410X(15)00981-0. (via http://www.ncbi.nlm.nih.gov/pubmed/26206270)
The yield of influenza antigen may significantly vary between vaccine strains; for example the A/California/07/09 (H1N1)-X179A vaccine virus, prepared during 2009 influenza pandemic, presented a low antigen ...

DLUGOLENSKI D, Jones L, Howerth E, Wentworth D, et. Swine Influenza Virus PA and Neuraminidase Gene Reassortment into Human H1N1 Influenza Virus Is Associated with an Altered Pathogenic Phenotype Linked to Increased MIP-2 Expression. J Virol. 2015 May;89(10):5651-67..  Abstract  
submitted by kickingbird at Jul, 27, 2015 from J Virol. 2015 May;89(10):5651-67. (via http://www.ncbi.nlm.nih.gov/pubmed/25762737)
Swine are susceptible to infection by both avian and human influenza viruses, and this feature is thought to contribute to novel reassortant influenza viruses. In this study, the influenza virus reassortment ...

VER LS, Marcos-Villar L, Landeras-Bueno S, Nieto A. The cellular factor NXP2/MORC3 is a positive regulator for influenza virus multiplication. J Virol. 2015 Jul 22. pii: JVI.01530-15..  Abstract  
submitted by kickingbird at Jul, 27, 2015 from J Virol. 2015 Jul 22. pii: JVI.01530-15. (via http://www.ncbi.nlm.nih.gov/pubmed/26202233)
Transcription and replication of the influenza A virus are carried out in the nucleus of the infected cells in the context of viral ribonucleoproteins (RNPs). The viral polymerase responsible for these ...

SHIN DL, Hatesuer B, Bergmann S, Nedelko T, et al. Protection from severe influenza infections in mice carrying the Mx1 influenza resistance gene strongly depends on genetic background. J Virol. 2015 Jul 22. pii: JVI.01305-15.  Abstract  
submitted by kickingbird at Jul, 27, 2015 from J Virol. 2015 Jul 22. pii: JVI.01305-15 (via http://www.ncbi.nlm.nih.gov/pubmed/26202236)
Influenza infections represent a serious threat to human health. Both extrinsic and intrinsic factors determine the severity of influenza disease. The MX dynamin-like GTPase 1 (Mx1) gene has been shown ...

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