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2024-11-26 3:55:22
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Zheng J, Wen L, Yen HL, Liu M, Liu Y, Teng O, Wu W. Phenotypic and functional characteristics of a novel influenza hemagglutinin-specific memory NK cell. J Virol. 2021 Apr 7:JVI.00165-21.  Abstract  
submitted by kickingbird at Apr, 9, 2021 from J Virol. 2021 Apr 7:JVI.00165-21 (via https://jvi.asm.org/content/early/2021/04/02/JVI.00165-21)
Immune memory represents the most efficient defense against invasion and transmission of infectious pathogens. In contrast to memory T and B cells, the roles of innate immunity in recall responses remain ...

Mori K, Ohniwa RL, Takizawa N, Naito T, Saito M. Development of a Genetically Stable Live Attenuated Influenza Vaccine Strain using an Engineered High-Fidelity Viral Polymerase. J Virol. 2021 Apr 7:JVI.00493-21.  Abstract  
submitted by kickingbird at Apr, 9, 2021 from J Virol. 2021 Apr 7:JVI.00493-21 (via https://jvi.asm.org/content/early/2021/04/02/JVI.00493-21)
RNA viruses demonstrate a vast range of variants, called quasispecies, due to error-prone replication by viral RNA-dependent RNA polymerase. Although live attenuated vaccines are effective in preventing ...

Giurgea LT, Park JK, Walters KA, Scherler K, Cerva. The effect of calcium and magnesium on activity, immunogenicity, and efficacy of a recombinant N1/N2 neuraminidase vaccine. NPJ Vaccines. 2021 Apr 6;6(1):48.  Abstract  
submitted by kickingbird at Apr, 8, 2021 from NPJ Vaccines. 2021 Apr 6;6(1):48 (via https://www.nature.com/articles/s41541-021-00310-x)
Despite the importance of immunity against neuraminidase (NA), NA content and immunogenicity are neglected in current influenza vaccines. To address this, a recombinant N1/N2 NA vaccine (NAV) was developed. ...

Fallah Mehrabadi MH, Tehrani F, Shoushtari A, Baho. Outbreak Investigation of Officially Reported and Highly Pathogenic Avian Influenza (H5N8 Subtype) in Iran During 2016. Arch Razi Inst. 2021 Mar;76(1):17-29.  Abstract  
submitted by kickingbird at Apr, 6, 2021 from Arch Razi Inst. 2021 Mar;76(1):17-29 (via https://archrazi.areeo.ac.ir/article_121531.html)
On 14 November 2016, an outbreak of highly pathogenic avian influenza (HPA) was reported from a commercial layer farm located in Malard, Tehran Province, Iran. This study aimed to investigate the HPAI ...

Hu Z, Zhao J, Shi L, Hu J, Hu S, Liu X. Identification of the dominant non-neutralizing epitope in the haemagglutinin of H7N9 avian influenza virus. Virus Res. 2021 Apr 2:198409.  Abstract  
submitted by kickingbird at Apr, 6, 2021 from Virus Res. 2021 Apr 2:198409 (via https://www.sciencedirect.com/science/article/abs/pii/S01681)
H7N9 avian influenza vaccines induce high levels of non-neutralizing (nonNeu) antibodies against the haemagglutinin (HA). However, the antigenic epitopes underlying this particular antibody response are ...

Liu Y, Zhan L, Wang Y, Kangas J, Larkin D, Boulwar. Improved Influenza Diagnostics through Thermal Contrast Amplification. Diagnostics (Basel). 2021 Mar 7;11(3):462.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Diagnostics (Basel). 2021 Mar 7;11(3):462 (via https://www.mdpi.com/2075-4418/11/3/462)
Influenza poses a serious health threat and creates an economic burden for people around the world. The accurate diagnosis of influenza is critical to the timely clinical treatment of patients and the ...

Shah P, Sobash PT, Vedala K, Kakkera K, Kamoga GR. An Uncommon Case of Secondary Organizing Pneumonia Due to Influenza Type B. Clin Pract. 2021 Mar 10;11(1):174-177.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Clin Pract. 2021 Mar 10;11(1):174-177 (via https://www.mdpi.com/2039-7283/11/1/24)
Secondary organizing pneumonia refers to a disease process caused by pulmonary tissue injury. Various insults can cause secondary organizing pneumonia, including multiple types of infections and cancer. ...

Tung Yep A, Takeuchi Y, Engelhardt OG, Hufton SE. Broad Reactivity Single Domain Antibodies against Influenza Virus and Their Applications to Vaccine Potency Testing and Immunotherapy. Biomolecules. 2021 Mar 10;11(3):407.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Biomolecules. 2021 Mar 10;11(3):407 (via https://www.mdpi.com/2218-273X/11/3/407)
The antigenic variability of influenza presents many challenges to the development of vaccines and immunotherapeutics. However, it is apparent that there are epitopes on the virus that have evolved to ...

Matsuzaki Y, Sugawara K, Shimotai Y, Kadowaki Y, H. Growth Kinetics of Influenza C Virus Antigenic Mutants That Escaped from Anti-Hemagglutinin Esterase Monoclonal Antibodies and Viral Antigenic Changes Found in Field Isolates. Viruses. 2021 Mar 3;13(3):401.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Viruses. 2021 Mar 3;13(3):401 (via https://www.mdpi.com/1999-4915/13/3/401)
The antigenicity of the hemagglutinin esterase (HE) glycoprotein of influenza C virus is known to be stable; however, information about residues related to antigenic changes has not yet been fully acquired. ...

Torelli A, Gianchecchi E, Monti M, Piu P, Barnesch. Effect of Repeated Freeze-Thaw Cycles on Influenza Virus Antibodies. Vaccines (Basel). 2021 Mar 17;9(3):267.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Vaccines (Basel). 2021 Mar 17;9(3):267 (via https://www.mdpi.com/2076-393X/9/3/267)
Background: Vaccine effectiveness relies on various serological tests, whose aim is the measurement of antibody titer in serum samples collected during clinical trials before and after vaccination. Among ...

Holwerda M, Laloli L, Wider M, Sch?necker L, Becke. Establishment of a Reverse Genetic System from a Bovine Derived Influenza D Virus Isolate. Viruses. 2021 Mar 18;13(3):502.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Viruses. 2021 Mar 18;13(3):502 (via https://www.mdpi.com/1999-4915/13/3/502)
The ruminant-associated influenza D virus (IDV) has a broad host tropism and was shown to have zoonotic potential. To identify and characterize molecular viral determinants influencing the host spectrum ...

Bogatcheva NV, Coleman ME. Concentrated Secretome of Adipose Stromal Cells Limits Influenza A Virus-Induced Lung Injury in Mice. Cells. 2021 Mar 24;10(4):720.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Cells. 2021 Mar 24;10(4):720 (via https://www.mdpi.com/2073-4409/10/4/720)
Despite vaccination and antivirals, influenza remains a communicable disease of high burden, with limited therapeutic options available to patients that develop complications. Here, we report the development ...

Nagashima KA, Mousa JJ. Next-Generation Influenza HA Immunogens and Adjuvants in Pursuit of a Broadly Protective Vaccine. Viruses. 2021 Mar 24;13(4):546.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Viruses. 2021 Mar 24;13(4):546 (via https://www.mdpi.com/1999-4915/13/4/546)
Influenza virus, a highly mutable respiratory pathogen, causes significant disease nearly every year. Current vaccines are designed to protect against circulating influenza strains of a given season. However, ...

Yang W, Schountz T, Ma W. Bat Influenza Viruses: Current Status and Perspective. Viruses. 2021 Mar 25;13(4):547.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Viruses. 2021 Mar 25;13(4):547 (via https://www.mdpi.com/1999-4915/13/4/547)
Bats are natural reservoirs for many viruses, including several that are zoonotic. Two unusual H17N10 and H18N11 influenza viruses have been found in New World bats. Although neither of these viruses have ...

Ilyicheva T, Marchenko V, Pyankova O, Moiseeva A,. Antibodies to Highly Pathogenic A/H5Nx (Clade 2.3.4.4) Influenza Viruses in the Sera of Vietnamese Residents. Pathogens. 2021 Mar 25;10(4):394.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Pathogens. 2021 Mar 25;10(4):394 (via https://www.mdpi.com/2076-0817/10/4/394)
To cause a pandemic, an influenza virus has to overcome two main barriers. First, the virus has to be antigenically new to humans. Second, the virus has to be directly transmitted from humans to humans. ...

Nemanichvili N, Berends AJ, Wubbolts RW, Gr?ne A,. Tissue Microarrays to Visualize Influenza D Attachment to Host Receptors in the Respiratory Tract of Farm Animals. Viruses. 2021 Mar 31;13(4):586.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Viruses. 2021 Mar 31;13(4):586 (via https://www.mdpi.com/1999-4915/13/4/586)
The trimeric hemagglutinin-esterase fusion protein (HEF) of influenza D virus (IDV) binds 9-O-acetylated sialic acid receptors, which are expressed in various host species. While cattle are the main reservoir ...

Zhou Y, Pu J, Wu Y. The Role of Lipid Metabolism in Influenza A Virus Infection. Pathogens. 2021 Mar 5;10(3):303.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Pathogens. 2021 Mar 5;10(3):303 (via https://www.mdpi.com/2076-0817/10/3/303)
Influenza A virus (IAV) is an important zoonotic pathogen that can cause disease in animals such as poultry and pigs, and it can cause infection and even death in humans, posing a serious threat to public ...

Tasker S, Wight O´Rourke A, Suyundikov A, Ja. Safety and Immunogenicity of a Novel Intranasal Influenza Vaccine (NasoVAX): A Phase 2 Randomized, Controlled Trial. Vaccines (Basel). 2021 Mar 5;9(3):224.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Vaccines (Basel). 2021 Mar 5;9(3):224 (via https://www.mdpi.com/2076-393X/9/3/224)
Annual influenza vaccination greatly reduces morbidity and mortality, but effectiveness remains sub-optimal. Weaknesses of current vaccines include low effectiveness against mismatched strains, lack of ...

Ganti K, Bagga A, DaSilva J, Shepard SS, Barnes JR. Avian Influenza A Viruses Reassort and Diversify Differently in Mallards and Mammals. Viruses. 2021 Mar 19;13(3):509.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Viruses. 2021 Mar 19;13(3):509 (via https://www.mdpi.com/1999-4915/13/3/509)
Reassortment among co-infecting influenza A viruses (IAVs) is an important source of viral diversity and can facilitate expansion into novel host species. Indeed, reassortment played a key role in the ...

Park BJ, Park MS, Lee JM, Song YJ. Specific Detection of Influenza A and B Viruses by CRISPR-Cas12a-Based Assay. Biosensors (Basel). 2021 Mar 19;11(3):88.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Biosensors (Basel). 2021 Mar 19;11(3):88 (via https://www.mdpi.com/2079-6374/11/3/88)
A rapid and accurate on-site diagnostic test for pathogens including influenza viruses is critical for preventing the spread of infectious diseases. Two types of influenza virus, A and B cause seasonal ...

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