Li Z, et al. A novel linear epitope crossing Group 1 and Group 2 influenza A viruses located in the helix A of HA2 derived from H7N9. Vet Microbiol. 2019 Jan;228:39-44.. Abstract
submitted by kickingbird at Dec, 30, 2018 from Vet Microbiol. 2019 Jan;228:39-44. (via https://www.ncbi.nlm.nih.gov/pubmed/30593378)
In this research, four monoclonal antibodies (mAbs) were first generated as an immunogen by using the GST fusion protein that carries the fusion peptide and helix A derived from H7N9 influenza A virus ...
Wang Z, et al. Pre-exposure with influenza A virus A/WSN/1933(H1N1) resulted in viral shedding reduction from pigs challenged with either swine H1N1 or H3N2 virus. Vet Microbiol. 2019 Jan;228:26-31. Abstract
submitted by kickingbird at Dec, 30, 2018 from Vet Microbiol. 2019 Jan;228:26-31 (via https://www.ncbi.nlm.nih.gov/pubmed/30593376)
There is an urgent need to develop a broad-spectrum vaccine that can effectively prevent or eliminate the spread of co-circulating swine influenza virus strains in multiple lineages or subtypes. We describe ...
An SH, Lee CY, Choi JG, Lee YJ, Kim JH, Kwon HJ. Generation of highly productive and mammalian nonpathogenic recombinant H9N2 avian influenza viruses by optimization of 3´end promoter and NS genome. Vet Microbiol. 2019 Jan;228:213-218.. Abstract
submitted by kickingbird at Dec, 30, 2018 from Vet Microbiol. 2019 Jan;228:213-218. (via https://www.ncbi.nlm.nih.gov/pubmed/30593370)
We developed A/PR/8/34 (PR8) virus-based reverse genetics system in which six internal genes of PR8 and attenuated hemagglutinin and intact neuraminidase genes of field avian influenza viruses (AIVs) have ...
Fleming-Canepa X, et al. Duck innate immune responses to high and low pathogenicity H5 avian influenza viruses. Vet Microbiol. 2019 Jan;228:101-111. Abstract
submitted by kickingbird at Dec, 30, 2018 from Vet Microbiol. 2019 Jan;228:101-111 (via https://www.ncbi.nlm.nih.gov/pubmed/30593354)
Ducks are the reservoir host of influenza A viruses, and are permissive for replication of most strains, yet can elicit robust innate immune responses to highly pathogenic strains. Tissue tropism and viral ...
Yu Z, He H, Cheng K, Wu J, Gao Y, Chen W, et al. Genetic characterization of an H13N2 low pathogenic avian influenza virus isolated from gulls in China. Transbound Emerg Dis. 2018 Dec 22.. Abstract
submitted by kickingbird at Dec, 25, 2018 from Transbound Emerg Dis. 2018 Dec 22. (via https://www.ncbi.nlm.nih.gov/pubmed/30578616)
Low pathogenic avian influenza viruses circulate in wild birds but are occasionally transmitted to other species, including poultry, mammals, and humans. To date, infections with low pathogenic avian influenza ...
Rahim MN, Klewes L, Zahedi-Amiri A, et al. Global Interactomics Connect Nuclear Mitotic Apparatus Protein NUMA1 to Influenza Virus Maturation. Viruses. 2018 Dec 19;10(12). Abstract
submitted by kickingbird at Dec, 24, 2018 from Viruses. 2018 Dec 19;10(12) (via https://www.ncbi.nlm.nih.gov/pubmed/30572664)
Influenza A virus (IAV) infections remain a major human health threat. IAV has enormous genetic plasticity and can rapidly escape virus-targeted anti-viral strategies. Thus, there is increasing interest ...
Skibinski DAG, et al. Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine. Sci Rep. 2018 Dec 20;8(1):18007. Abstract
submitted by kickingbird at Dec, 24, 2018 from Sci Rep. 2018 Dec 20;8(1):18007 (via https://www.ncbi.nlm.nih.gov/pubmed/30573748)
Cell mediated immunity plays a vital role in defense against influenza infection in humans. Less is known about the role of vaccine-induced cell mediated immunity and the cytokine responses elicited. We ...
Hong BT, Cheng YE, Cheng TJ, Fang JM. Boronate, trifluoroborate, sulfone, sulfinate and sulfonate congeners of oseltamivir carboxylic acid: Synthesis and anti-influenza activity. Eur J Med Chem. 2018 Dec 13;163:710-721. Abstract
submitted by kickingbird at Dec, 24, 2018 from Eur J Med Chem. 2018 Dec 13;163:710-721 (via https://www.ncbi.nlm.nih.gov/pubmed/30576902)
Tamiflu readily undergoes endogenous hydrolysis to give oseltamivir carboxylic acid (OC) as the active anti-influenza agent to inhibit the viral neuraminidase (NA). GOC is derived from OC by replacing ...
Sealy JE, Yaqub T, Peacock TP, Chang P, et al. Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential. Emerg Infect Dis. 2019 Jan;25(1):63-72. Abstract
submitted by kickingbird at Dec, 23, 2018 from Emerg Infect Dis. 2019 Jan;25(1):63-72 (via https://wwwnc.cdc.gov/eid/article/25/1/18-0616_article)
We characterized 55 influenza A(H9N2) viruses isolated in Pakistan during 2014-2016 and found that the hemagglutinin gene is of the G1 lineage and that internal genes have differentiated into a variety ...
Chen H, Alvarez JJS, Ng SH, Nielsen R, Zhai W. Passage adaptation correlates with the reduced efficacy of the influenza vaccine. Clin Infect Dis. 2018 Dec 18.. Abstract
submitted by kickingbird at Dec, 23, 2018 from Clin Infect Dis. 2018 Dec 18. (via https://www.ncbi.nlm.nih.gov/pubmed/30561532)
Background: As a dominant seasonal influenza virus, H3N2 virus rapidly evolves in human and is a constant threat to public health. Despite sustained research efforts, the efficacy of H3N2 vaccine has decreased ...
Zhang J, Su R, Jian X, An H, Jiang R, Mok CKP. The D253N Mutation in the Polymerase Basic 2 Gene in Avian Influenza (H9N2) Virus Contributes to the Pathogenesis of the Virus in Mammalian Hosts. Virol Sin. 2018 Dec 19.. Abstract
submitted by kickingbird at Dec, 23, 2018 from Virol Sin. 2018 Dec 19. (via https://www.ncbi.nlm.nih.gov/pubmed/30569291)
Mutations in the polymerase basic 2 (PB2) gene of avian influenza viruses are important signatures for their adaptation to mammalian hosts. Various adaptive mutations have been identified around the 627 ...
Rojas-Quintero J, et al. Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection. JCI Insight. 2018 Dec 20;3(24).. Abstract
submitted by kickingbird at Dec, 23, 2018 from JCI Insight. 2018 Dec 20;3(24). (via https://www.ncbi.nlm.nih.gov/pubmed/30568032)
Matrix metalloproteinase-9 (MMP-9) cleaves various proteins to regulate inflammatory and injury responses. However, MMP-9's activities during influenza A viral (IAV) infections are incompletely understood. ...
Obadan AO, et al. Flexibility in vitro of amino acid 226 in the receptor-binding site of an H9 subtype influenza A virus and its effect in vivo on virus replication, tropism, and transmission. J Virol. 2018 Dec 19.. Abstract
submitted by kickingbird at Dec, 23, 2018 from J Virol. 2018 Dec 19. (via https://www.ncbi.nlm.nih.gov/pubmed/30567980)
Influenza A viruses remain a significant public health threat causing more than 300,000 hospitalizations in the United states during 2015-2016 season alone. While only few IAVs of avian origin have been ...
Yin R, Zhou X, Zheng J, Kwoh CK. Computational identification of physicochemical signatures for host tropism of influenza A virus. J Bioinform Comput Biol. 2018 Oct 30:1840023.. Abstract
submitted by kickingbird at Dec, 23, 2018 from J Bioinform Comput Biol. 2018 Oct 30:1840023. (via https://www.ncbi.nlm.nih.gov/pubmed/30567479)
Avian influenza viruses from migratory birds have managed to cross host species barriers and infected various hosts like human and swine. Epidemics and pandemics might occur when influenza viruses are ...
Howard LM, et al. AS03-Adjuvanted H5N1 Avian Influenza Vaccine Modulates Early Innate Immune Signatures In Human Peripheral Blood Mononuclear Cells. J Infect Dis. 2018 Dec 19. Abstract
submitted by kickingbird at Dec, 21, 2018 from J Infect Dis. 2018 Dec 19 (via https://www.ncbi.nlm.nih.gov/pubmed/30566602)
Background: Adjuvant System 03 (AS03) markedly enhances responses to influenza A/H5N1 vaccines, but the mechanisms of this enhancement are incompletely understood.Methods: Using RNA-Seq on peripheral blood ...
Zhou P, et al. Serological Evidence of H3N2 Canine Influenza Virus Infection among Horses with Dog Exposure. Transbound Emerg Dis. 2018 Dec 19. Abstract
submitted by kickingbird at Dec, 21, 2018 from Transbound Emerg Dis. 2018 Dec 19 (via https://www.ncbi.nlm.nih.gov/pubmed/30565867)
Currently, Canine influenza virus (CIV) H3N2 is continuously circulating in dog populations in China, Korea, and the United States (US). Both influenza SA-α-2,3-Gal and SA-α-2,6-Gal receptors have been ...
Amaro RE, et al. A Computational Assay that Explores the Hemagglutinin/Neuraminidase Functional Balance Reveals the Neuraminidase Secondary Site as a Novel Anti-Influenza Target. ACS Cent Sci. 2018 Nov 28;4(11):1570-1577. Abstract
submitted by kickingbird at Dec, 20, 2018 from ACS Cent Sci. 2018 Nov 28;4(11):1570-1577 (via https://www.ncbi.nlm.nih.gov/pubmed/30555910)
Studies of pathogen-host specificity, virulence, and transmissibility are critical for basic research as well as for assessing the pandemic potential of emerging infectious diseases. This is especially ...
Han L, et al. The evolution and molecular characteristics of H9N2 avian influenza viruses in Jiangxi of China. J Med Virol. 2018 Dec 17. Abstract
submitted by kickingbird at Dec, 20, 2018 from J Med Virol. 2018 Dec 17 (via https://www.ncbi.nlm.nih.gov/pubmed/30560545)
To understand the evolution and molecular characteristics of Jiangxi H9N2 viruses, we isolated 17 viruses in 2011 and analyzed their characteristics. Phylogenetic analyses revealed that their hemagglutinin ...
Nogales A, Martinez-Sobrido L, Topham DJ, et al. Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins. Viruses. 2018 Dec 12;10(12).. Abstract
submitted by kickingbird at Dec, 18, 2018 from Viruses. 2018 Dec 12;10(12). (via https://www.ncbi.nlm.nih.gov/pubmed/30545063)
Influenza A viruses (IAV) can infect a broad range of animal hosts, including humans. In humans, IAV causes seasonal annual epidemics and occasional pandemics, representing a serious public health and ...
York IA, Stevens J, Alymova IV. Influenza Virus N-linked Glycosylation and Innate Immunity. Biosci Rep. 2018 Dec 14. Abstract
submitted by kickingbird at Dec, 18, 2018 from Biosci Rep. 2018 Dec 14 (via https://www.ncbi.nlm.nih.gov/pubmed/30552137)
Influenza viruses cause seasonal epidemics and sporadic pandemics in humans. The virus's ability to change its antigenic nature through mutation and recombination, and the difficulty in developing highly ...
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