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Gopal R, et al. STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection. Front Immunol. 2018 Sep 25;9:2151.  Abstract  
submitted by kickingbird at Oct, 21, 2018 from Front Immunol. 2018 Sep 25;9:2151 (via https://www.ncbi.nlm.nih.gov/pubmed/30337919)
Influenza is a common respiratory virus that infects between 5 and 20% of the US population and results in 30,000 deaths annually. A primary cause of influenza-associated death is secondary bacterial pneumonia. ...

Lisovski S, et al. The roles of migratory and resident birds in local avian influenza infection dynamics. J Appl Ecol. 2018 Nov;55(6):2963-2975..  Abstract  
submitted by kickingbird at Oct, 21, 2018 from J Appl Ecol. 2018 Nov;55(6):2963-2975. (via https://www.ncbi.nlm.nih.gov/pubmed/30337766)
Migratory birds are an increasing focus of interest when it comes to infection dynamics and the spread of avian influenza viruses (AIV). However, we lack detailed understanding migratory birds' contribution ...

Mohebbi A, et al. Molecular Epidemiology of the Hemagglutinin gene of prevalent influenza virus A/H1N1/pdm09 among patient in Iran. Virus Res. 2018 Oct 15.  Abstract  
submitted by kickingbird at Oct, 21, 2018 from Virus Res. 2018 Oct 15 (via https://www.ncbi.nlm.nih.gov/pubmed/30336188)
In 2015, the influenza virus A/H1N1/pdm09 strain outbreak became prevalent throughout the different provinces of Iran. There are relatively limited complete genetic sequences available for this virus from ...

Kumar P, Gaur P, Kumari R, Lal SK. Influenza A virus neuraminidase protein interacts with Hsp90, to stabilize itself and enhance cell survival. J Cell Biochem. 2018 Oct 18..  Abstract  
submitted by kickingbird at Oct, 21, 2018 from J Cell Biochem. 2018 Oct 18. (via https://www.ncbi.nlm.nih.gov/pubmed/30335904)
Neuraminidase protein (NA) of influenza A virus (IAV) is popularly known for its sialidase function to assist in the release of progeny virus. However, involvement of NA in other stages of the IAV life ...

Zheng Y, et al. Canine Influenza Virus is Mildly Restricted by Canine Tetherin Protein. Viruses. 2018 Oct 16;10(10).  Abstract  
submitted by kickingbird at Oct, 21, 2018 from Viruses. 2018 Oct 16;10(10) (via https://www.ncbi.nlm.nih.gov/pubmed/30332780)
Tetherin (BST2/CD317/HM1.24) has emerged as a key host-cell ·defence molecule that acts by inhibiting the release and spread of diverse enveloped virions from infected cells. We analysed the biological ...

Im SP, et al. Potential Use of Genetically Engineered Variable Lymphocyte Receptor B Specific to Avian Influenza Virus H9N2. J Immunol. 2018 Oct 17.  Abstract  
submitted by kickingbird at Oct, 21, 2018 from J Immunol. 2018 Oct 17 (via https://www.ncbi.nlm.nih.gov/pubmed/30333123)
The variable lymphocyte receptor (VLR) B of jawless vertebrates functions as a secreted Ab of jawed vertebrates and has emerged as an alternative Ab with a single polypeptide chain. After observing an ...

Martínez-Sobrido L, Peersen O, Nogales A.. Temperature Sensitive Mutations in Influenza A Viral Ribonucleoprotein Complex Responsible for the Attenuation of the Live Attenuated Influenza Vaccine. Viruses. 2018 Oct 15;10(10).  Abstract  
submitted by kickingbird at Oct, 18, 2018 from Viruses. 2018 Oct 15;10(10) (via https://www.ncbi.nlm.nih.gov/pubmed/30326610)
Live attenuated influenza vaccines (LAIV) have prevented morbidity and mortality associated with influenza viral infections for many years and represent the best therapeutic option to protect against influenza ...

Mahesutihan M, et al. CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus. Virol Sin. 2018 Oct 16.  Abstract  
submitted by kickingbird at Oct, 18, 2018 from Virol Sin. 2018 Oct 16 (via https://www.ncbi.nlm.nih.gov/pubmed/30328013)
Cyclophilin A (CypA) is a peptidyl-prolyl cis/trans isomerase that interacts with the matrix protein (M1) of influenza A virus (IAV) and restricts virus replication by regulating the ubiquitin-proteasome-mediated ...

Shirey KA, et al. Novel role of gastric releasing peptide-mediated signaling in the host response to influenza infection. Mucosal Immunol. 2018 Oct 16..  Abstract  
submitted by kickingbird at Oct, 18, 2018 from Mucosal Immunol. 2018 Oct 16. (via https://www.ncbi.nlm.nih.gov/pubmed/30327535)
Gastrin-releasing peptide (GRP) is an evolutionarily well-conserved neuropeptide that was originally recognized for its ability to mediate gastric acid secretion in the gut. More recently, however, GRP ...

Kissler SM, et al. Geographic transmission hubs of the 2009 influenza pandemic in the United States. Epidemics. 2018 Oct 10..  Abstract  
submitted by kickingbird at Oct, 18, 2018 from Epidemics. 2018 Oct 10. (via https://www.ncbi.nlm.nih.gov/pubmed/30327253)
A key issue in infectious disease epidemiology is to identify and predict geographic sites of epidemic establishment that contribute to onward spread, especially in the context of invasion waves of emerging ...

Er JZ, Koean RAG, Ding JL. Loss of T-bet confers survival advantage to influenza-bacterial superinfection. EMBO J. 2018 Oct 15..  Abstract  
submitted by kickingbird at Oct, 18, 2018 from EMBO J. 2018 Oct 15. (via https://www.ncbi.nlm.nih.gov/pubmed/30322895)
The transcription factor, T-bet, regulates type 1 inflammatory responses against a range of infections. Here, we demonstrate a previously unaddressed role of T-bet, to influenza virus and bacterial superinfection. ...

Krischuns T, et al. Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells. Front Immunol. 2018 Sep 28;9:2229..  Abstract  
submitted by kickingbird at Oct, 18, 2018 from Front Immunol. 2018 Sep 28;9:2229. (via https://www.ncbi.nlm.nih.gov/pubmed/30323812)
Human infection with highly pathogenic avian influenza viruses (HPAIV) is often associated with severe tissue damage due to hyperinduction of interferons and proinflammatory cytokines. The reasons for ...

Cui X, et al. A 113-amino-acid truncation at the NS1 C-terminus is a determinant for viral replication of H5N6 avian influenza virus in vitro and in vivo. Vet Microbiol. 2018 Nov;225:6-16.  Abstract  
submitted by kickingbird at Oct, 18, 2018 from Vet Microbiol. 2018 Nov;225:6-16 (via https://www.ncbi.nlm.nih.gov/pubmed/30322535)
Virulence of highly pathogenic avian influenza viruses (AIV) is determined by multiple genes and their encoded proteins. In particular, the nonstructural protein 1 (NS1) of viruses is a multifunctional ...

Wu NC, et al. Recurring and Adaptable Binding Motifs in Broadly Neutralizing Antibodies to Influenza Virus Are Encoded on the D3-9 Segment of the Ig Gene. Cell Host Microbe. 2018 Oct 10;24(4):569-578.e4.  Abstract  
submitted by kickingbird at Oct, 18, 2018 from Cell Host Microbe. 2018 Oct 10;24(4):569-578.e4 (via https://www.ncbi.nlm.nih.gov/pubmed/30308159)
Discovery and characterization of broadly neutralizing antibodies (bnAbs) to the influenza hemagglutinin (HA) stem have provided insights for the development of a universal flu vaccine. Identification ...

Vera Ehrenstein, et al. Oseltamivir in pregnancy and birth outcomes. BMC Infectious Diseases201818:519.  Abstract  
submitted by kickingbird at Oct, 18, 2018 from BMC Infectious Diseases201818:519 (via https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128)
BackgroundPrenatal exposure to influenza or fever is associated with risk of congenital malformations. Oseltamivir is used to treat influenza and to provide post-exposure prophylaxis. We examined the association ...

Tomar J, et al. Passive inhalation of dry powder influenza vaccine formulations completely protects chickens against H5N1 lethal viral challenge. Eur J Pharm Biopharm. 2018 Oct 9..  Abstract  
submitted by kickingbird at Oct, 17, 2018 from Eur J Pharm Biopharm. 2018 Oct 9. (via https://www.ncbi.nlm.nih.gov/pubmed/30312742)
Bird to human transmission of high pathogenicity avian influenza virus (HPAIV) poses a significant risk of triggering a flu pandemic in the human population. Therefore, vaccination of susceptible poultry ...

Zhang J, et al. Role of c-Jun terminal kinase (JNK) activation in influenza A virus-induced autophagy and replication. Virology. 2018 Oct 10;526:1-12..  Abstract  
submitted by kickingbird at Oct, 17, 2018 from Virology. 2018 Oct 10;526:1-12. (via https://www.ncbi.nlm.nih.gov/pubmed/30316042)
The non-structural protein 1 (NS1) of different influenza A virus (IAV) strains can differentially regulate the activity of c-Jun terminal kinase (JNK) and PI-3 kinase (PI3K). Whether varying JNK and PI3K ...

Ravanetti L, et al. IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive anti-viral immunity. J Allergy Clin Immunol. 2018 Oct 11.  Abstract  
submitted by kickingbird at Oct, 17, 2018 from J Allergy Clin Immunol. 2018 Oct 11 (via https://www.ncbi.nlm.nih.gov/pubmed/30316823)
BACKGROUND: Influenza virus triggers severe exacerbations of asthma for which no adequate treatment is available. It is known that IL-33 levels correlate with exacerbation severity, but its role in the ...

Noshi T, et al. In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit. Antiviral Res. 2018 Oct 11.  Abstract  
submitted by kickingbird at Oct, 17, 2018 from Antiviral Res. 2018 Oct 11 (via https://www.ncbi.nlm.nih.gov/pubmed/30316915)
Cap-dependent endonuclease (CEN) resides in the PA subunit of the influenza virus and mediates the critical "cap-snatching" step of viral RNA transcription, which is considered to be a promising anti-influenza ...

Zou G, et al. Comprehensive analysis of N-glycans in IgG purified from ferrets with or without influenza A virus infection. J Biol Chem. 2018 Oct 12..  Abstract  
submitted by kickingbird at Oct, 17, 2018 from J Biol Chem. 2018 Oct 12. (via https://www.ncbi.nlm.nih.gov/pubmed/30315103)
Influenza viruses cause contagious respiratory infections resulting in significant economic burdens to communities. Production of influenza-specific immunoglobulins, specifically IgGs, is one of the major ...

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