Sano K, Saito S, Suzuki T, Kotani O, Ainai A, van. An influenza HA stalk reactive polymeric IgA antibody exhibits anti-viral function regulated by binary interaction between HA and the antibody. PLoS One. 2021 Jan 7;16(1):e0245244. Abstract
submitted by kickingbird at Jan, 10, 2021 from PLoS One. 2021 Jan 7;16(1):e0245244 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
IgA antibodies, which are secreted onto the mucosal surface as secretory IgA antibodies (SIgAs), play an important role in preventing influenza virus infection. A recent study reported that anti-hemagglutinin ...
Wang Q, Sun Z, Li J, Qin T, Ma H, Chen S, Peng D,. Identification of a universal antigen epitope of influenza A virus using peptide microarray. BMC Vet Res. 2021 Jan 7;17(1):22. Abstract
submitted by kickingbird at Jan, 10, 2021 from BMC Vet Res. 2021 Jan 7;17(1):22 (via https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-)
Background: Hemagglutinin is a major surface protein in influenza A virus (IAV), and HA2 is relative conserved among different IAVs. It will be meaningful to identify broad-spectrum epitopes based on the ...
Yamazaki T, Biswas M, Kosugi K, Nagashima M, Inui. A Novel Gene Delivery Vector of Agonistic Anti-Radioprotective 105 Expressed on Cell Membranes Shows Adjuvant Effect for DNA Immunization Against Influenza. Front Immunol. 2020 Dec 22;11:606518. Abstract
submitted by kickingbird at Jan, 10, 2021 from Front Immunol. 2020 Dec 22;11:606518 (via https://www.frontiersin.org/articles/10.3389/fimmu.2020.6065)
Radioprotective 105 (RP105) (also termed CD180) is an orphan and unconventional Toll-like receptor (TLR) that lacks an intracellular signaling domain. The agonistic anti-RP105 monoclonal antibody (mAb) ...
Feng M, Zhang Q, Wu W, Chen L, Gu S, Ye Y, Zhong Y. Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-κB and JAK-STAT Signaling Pathways. J Virol. 2021 Jan 6:JVI.02038-20. Abstract
submitted by kickingbird at Jan, 8, 2021 from J Virol. 2021 Jan 6:JVI.02038-20 (via https://jvi.asm.org/content/early/2021/01/05/JVI.02038-20)
Guanylate-binding protein 7 (GBP7) belongs to the GBP family, which plays key roles in mediating innate immune responses to intracellular pathogens. Thus far, GBP7 has been reported to be a critical cellular ...
Patil A, Anhlan D, Ferrando V, Mecate-Zambrano A,. Phosphorylation of influenza A virus NS1 at serine 205 mediates its viral polymerase-enhancing function. J Virol. 2021 Jan 6:JVI.02369-20. Abstract
submitted by kickingbird at Jan, 8, 2021 from J Virol. 2021 Jan 6:JVI.02369-20 (via https://jvi.asm.org/content/early/2021/01/05/JVI.02369-20)
Influenza A virus (IAV) non-structural protein 1 (NS1) is a protein with multiple functions that are regulated by phosphorylation. Phospho-proteomic screening of H1N1-infected cells identified NS1 to be ...
Zhang X, Pu J, Sun Y, Yuhai B, Jiang Z, Xu G, Zhan. Neurovirulence of avian influenza virus is dependent on the interaction of viral NP protein with host factor FMRP in the murine brain. J Virol. 2021 Jan 6:JVI.01272-20. Abstract
submitted by kickingbird at Jan, 8, 2021 from J Virol. 2021 Jan 6:JVI.01272-20 (via https://jvi.asm.org/content/early/2021/01/05/JVI.01272-20)
Avian influenza viruses (AIVs) are zoonotic viruses that exhibit a range infectivity and severity in the human host. Severe human cases of AIVs infection are often accompanied by neurological symptoms, ...
Takayama I, Nguyen BG, Dao CX, Pham TT, Dang TQ, T. Next-Generation Sequencing Analysis of the Within-Host Genetic Diversity of Influenza A(H1N1)pdm09 Viruses in the Upper and Lower Respiratory Tracts of Patients with Severe Influenza. mSphere. 2021 Jan 6;6(1):e01043-20. Abstract
submitted by kickingbird at Jan, 8, 2021 from mSphere. 2021 Jan 6;6(1):e01043-20 (via https://msphere.asm.org/content/6/1/e01043-20)
The influenza A(H1N1)pdm09 virus emerged in April 2009 with an unusual incidence of severe disease and mortality, and currently circulates as a seasonal influenza virus. Previous studies using consensus ...
Gong W, Huang K, Zhang Y, He X, Li C, Mao H, Wei Y. Transcriptome Profiles of Highly Pathogenic Pure Avian H7N9 Virus-Infected Lungs of BALB/c Mice. Front Vet Sci. 2020 Dec 21;7:603584. Abstract
submitted by kickingbird at Jan, 8, 2021 from Front Vet Sci. 2020 Dec 21;7:603584 (via https://www.frontiersin.org/articles/10.3389/fvets.2020.6035)
Avian influenza A (H7N9) viruses emerged in China in 2013 and caused a zoonotic disease associated with a high case-fatality ratio of more than 30%. Transcriptional profiles obtained using animal models ...
Lewis NS, Banyard AC, Whittard E, Karibayev T, Kaf. Emergence and spread of novel H5N8, H5N5 and H5N1 clade 188.8.131.52 highly pathogenic avian influenza in 2020. Emerg Microbes Infect. 2021 Jan 5:1-10. Abstract
submitted by kickingbird at Jan, 6, 2021 from Emerg Microbes Infect. 2021 Jan 5:1-10 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1)
Analyses of HPAI H5 viruses from poultry outbreaks across a wide Eurasian region since July 2020 including the Russian Federation, Republics of Iraq and Kazakhstan, and recent detections in migratory waterfowl ...
Damjanovska S, Smith C, Sayin I, Burant CJ, Graven. Adjuvant effect of type I interferon induced by many but not all commercial influenza vaccines. Vaccine. 2020 Dec 31:S0264-410X(20)31631-5. Abstract
submitted by kickingbird at Jan, 4, 2021 from Vaccine. 2020 Dec 31:S0264-410X(20)31631-5 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Background: Seasonal influenza vaccines approved and offered in the United States have varying reported degrees of effectiveness year over year and between manufacturers. Influenza vaccines produced from ...
Liu Y, Li S, Sun H, Pan L, Cui X, Zhu X, Feng Y, L. Variation and Molecular Basis for Enhancement of Receptor Binding of H9N2 Avian Influenza Viruses in China Isolates. Front Microbiol. 2020 Dec 17;11:602124. Abstract
submitted by kickingbird at Jan, 4, 2021 from Front Microbiol. 2020 Dec 17;11:602124 (via https://pubmed.ncbi.nlm.nih.gov/33391219/)
Currently, H9N2 avian influenza viruses (H9N2 AIVs) globally circulate in poultry and have acquired some adaptation to mammals. However, it is not clear what the molecular basis is for the variation in ...
Bai R, Sikkema RS, Munnink BBO, Li CR, Wu J, Zou L. Exploring utility of genomic epidemiology to trace origins of highly pathogenic influenza A/H7N9 in Guangdong. Virus Evol. 2020 Dec 18;6(2):veaa097. Abstract
submitted by kickingbird at Jan, 4, 2021 from Virus Evol. 2020 Dec 18;6(2):veaa097 (via https://academic.oup.com/ve/article/6/2/veaa097/6041617)
The first highly pathogenic (HP) influenza A/H7N9 was reported in Guangdong in January 2017. To investigate the emergence and spread of HP A/H7N9 in Guangdong province, we sequenced 297 viruses (58 HP ...
Shen HX, Li X, Yang DQ, Ju HB, Ge FF, Wang J, Zhao. Phylogenetic Analysis and Evolutionary Dynamics of H3N2 Canine and Feline Influenza Virus Strains from 2006 to 2019. J Med Virol. 2021 Jan 2. Abstract
submitted by kickingbird at Jan, 3, 2021 from J Med Virol. 2021 Jan 2 (via https://pubmed.ncbi.nlm.nih.gov/33386745/)
H3N2 feline influenza virus (FIV) and canine influenza virus (CIV) are very common in cats and dogs. Due to the ability of influenza virus to spread across hosts and frequent contact between pets and people, ...
Veazey JM, Eliseeva SI, Hillman SE, Stiles K, Smyt. Inhibiting Protein Kinase D Promotes Airway Epithelial Barrier Integrity in Mouse Models of Influenza A Virus Infection. Front Immunol. 2020 Dec 14;11:580401. Abstract
submitted by kickingbird at Jan, 2, 2021 from Front Immunol. 2020 Dec 14;11:580401 (via https://www.frontiersin.org/articles/10.3389/fimmu.2020.5804)
Rationale: Protein kinase D (PKD) is a serine/threonine kinase family that is involved in a wide array of signaling pathways. Although PKD has been implicated in immune responses, relatively little is ...
Trov?o NS, Nolting JM, Slemons RD, Nelson MI, Bowm. The Evolutionary Dynamics of Influenza A Viruses Circulating in Mallards in Duck Hunting Preserves in Maryland, USA. Microorganisms. 2020 Dec 25;9(1):E40. Abstract
submitted by kickingbird at Dec, 31, 2020 from Microorganisms. 2020 Dec 25;9(1):E40 (via https://www.mdpi.com/2076-2607/9/1/40)
Duck hunting preserves (DHP) have resident populations of farm-raised mallard ducks, which create potential foci for the evolution of novel influenza A viruses (IAVs). Through an eleven-year (2003-2013) ...
Duev-Cohen A, Isaacson B, Berhani O, Charpak-Amika. Altered NKp46 Recognition and Elimination of Influenza B Viruses. Viruses. 2020 Dec 27;13(1):E34. Abstract
submitted by kickingbird at Dec, 31, 2020 from Viruses. 2020 Dec 27;13(1):E34 (via https://www.mdpi.com/1999-4915/13/1/34)
Every year, millions of people worldwide are infected with influenza, causing enormous health and economic problems. The most common type of influenza is influenza A. It is known that Natural Killer (NK) ...
Trinh TT, Duong BT, Nguyen ATV, Tuong HT, Hoang VT. Emergence of Novel Reassortant H1N1 Avian Influenza Viruses in Korean Wild Ducks in 2018 and 2019. Viruses. 2020 Dec 26;13(1):E30. Abstract
submitted by kickingbird at Dec, 31, 2020 from Viruses. 2020 Dec 26;13(1):E30 (via https://www.mdpi.com/1999-4915/13/1/30)
Influenza A virus subtype H1N1 has caused global pandemics like the "Spanish flu" in 1918 and the 2009 H1N1 pandemic several times. H1N1 remains in circulation and survives in multiple animal sources, ...
Dai M, Li S, Keyi Shi, Sun H, Zhao L, Deshui Yu, L. Comparative analysis of key immune protection factors in H9N2 avian influenza viruses infected and immunized specific pathogen-free chicken. Poult Sci. 2021 Jan;100(1):39-46. Abstract
submitted by kickingbird at Dec, 29, 2020 from Poult Sci. 2021 Jan;100(1):39-46 (via https://www.sciencedirect.com/science/article/pii/S003257912)
H9N2 avian influenza viruses (AIV) continue to circulate in vaccinated chicken flocks in China, which prompted us to investigate the differential immune protection factors induced by H9N2 AIV infection ...
Verhagen JH, Eriksson P, Leijten L, Blixt O, Olsen. Host range of influenza A virus H1 to H16 in Eurasian ducks based on tissue and receptor binding studies. J Virol. 2020 Dec 23:JVI.01873-20. Abstract
submitted by kickingbird at Dec, 29, 2020 from J Virol. 2020 Dec 23:JVI.01873-20 (via https://jvi.asm.org/content/early/2020/12/17/JVI.01873-20)
Dabbling and diving ducks partly occupy shared habitats, but have been reported to play different roles in wildlife infectious disease dynamics. Influenza A virus (IAV) epidemiology in wild birds has primarily ...
Wang Q, Pan W, Wang S, Pan C, Ning H, Huang S, Chi. Protein tyrosine phosphatase SHP2 suppresses host innate immunity against influenza A virus through regulating EGFR-mediated signaling. J Virol. 2020 Dec 23:JVI.02001-20. Abstract
submitted by kickingbird at Dec, 29, 2020 from J Virol. 2020 Dec 23:JVI.02001-20 (via https://jvi.asm.org/content/early/2020/12/17/JVI.02001-20)
Influenza A virus (IAV) emerges as a highly contagious pathogen, causing acute respiratory illnesses in human beings and animals and frequently giving rise to epidemic outbreaks. Evasion of IAV from host ...
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