Kiso M, Yamayoshi S, Murakami J, Kawaoka Y. Baloxavir marboxil treatment of nude mice infected with influenza A virus. J Infect Dis. 2019 Dec 14. Abstract
submitted by kickingbird at Dec, 16, 2019 from J Infect Dis. 2019 Dec 14 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
Immunocompromised patients infected with influenza virus require prolonged treatment with neuraminidase inhibitors, because these patients are not able to eradicate the virus from the respiratory tract, ...
Luckey D, et al. Immunity to Influenza is dependent on MHC II polymorphism: study with 2 HLA transgenic strains. Sci Rep. 2019 Dec 13;9(1):19061. Abstract
submitted by kickingbird at Dec, 16, 2019 from Sci Rep. 2019 Dec 13;9(1):19061 (via https://www.nature.com/articles/s41598-019-55503-1)
Major histocompatibility complex II (MHC II) molecules are involved in antigen presentation and the development of a functional adaptive immune response. Evolutionary selection for MHC molecules that effectively ...
Matos ADR, et al. Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities. Emerg Microbes Infect. 2019;8(1):1763-1776. Abstract
submitted by kickingbird at Dec, 15, 2019 from Emerg Microbes Infect. 2019;8(1):1763-1776 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Influenza is an acute respiratory infection causing high morbidity and mortality in annual outbreaks worldwide. Antiviral drugs are limited and pose the risk of resistance development, calling for new ...
Traxler S, et al. Volatile scents of influenza A and S. pyogenes (co-)infected cells. Sci Rep. 2019 Dec 11;9(1):18894. Abstract
submitted by kickingbird at Dec, 15, 2019 from Sci Rep. 2019 Dec 11;9(1):18894 (via https://www.nature.com/articles/s41598-019-55334-0)
Influenza A is a serious pathogen itself, but often leads to dangerous co-infections in combination with bacterial species such as Streptococcus pyogenes. In comparison to classical biochemical methods, ...
Qiu Y, et al. Mapping of a Novel H3-Specific Broadly Neutralizing Monoclonal Antibody Targeting the Hemagglutinin Globular Head Isolated from an Elite Influenza Virus-Immunized Donor Exhibiting Serological Breadth. J Virol. 2019 Dec 11. Abstract
submitted by kickingbird at Dec, 15, 2019 from J Virol. 2019 Dec 11 (via https://jvi.asm.org/content/early/2019/12/05/JVI.01035-19)
The discovery of potent and broadly protective influenza epitopes could lead to improved vaccines that are resistant to antigenic drift. Here, we describe human antibody C585, isolated from a vaccinee ...
Parsons L, et al. Influenza Hemagglutinins H2, H5, H6, and H11 are not Targets of Pulmonary Surfactant Protein D: N-glycan subtypes in host-pathogen interactions. J Virol. 2019 Dec 11. pii: JVI.01951-19.. Abstract
submitted by kickingbird at Dec, 15, 2019 from J Virol. 2019 Dec 11. pii: JVI.01951-19. (via https://jvi.asm.org/content/early/2019/12/05/JVI.01951-19)
Seasonal influenza carrying key hemagglutinin (HA) head region glycosylation sites can be removed from the lung by pulmonary surfactant protein D (SP-D). Little is known about HA head glycosylation of ...
Suttie A, et al. The evolution and genetic diversity of avian influenza A(H9N2) viruses in Cambodia, 2015-2016. PLoS One. 2019 Dec 9;14(12):e0225428.. Abstract
submitted by kickingbird at Dec, 11, 2019 from PLoS One. 2019 Dec 9;14(12):e0225428. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Low pathogenic A(H9N2) subtype avian influenza viruses (AIVs) were originally detected in Cambodian poultry in 2013, and now circulate endemically. We sequenced and characterised 64 A(H9N2) AIVs detected ...
Suttie A, et al. Diversity of A(H5N1) clade 126.96.36.199c avian influenza viruses with evidence of reassortment in Cambodia, 2014-2016. PLoS One. 2019 Dec 9;14(12):e0226108.. Abstract
submitted by kickingbird at Dec, 11, 2019 from PLoS One. 2019 Dec 9;14(12):e0226108. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
In Cambodia, highly pathogenic avian influenza A(H5N1) subtype viruses circulate endemically causing poultry outbreaks and zoonotic human cases. To investigate the genomic diversity and development of ...
Suehiro Sakaguchi, Junji Chida. Prion Protein is a Novel Modulator of Influenza: Potential Implications for Anti-Influenza Therapeutics. Curr. Issues Mol. Biol. (2020) 37: 21-32. Abstract
submitted by kickingbird at Dec, 11, 2019 from Curr. Issues Mol. Biol. (2020) 37: 21-32 (via https://www.caister.com/cimb/abstracts/v37/21.html)
Worldwide spread of influenza A virus (IAV) strains, which are resistant to currently available anti- influenza agents such as viral neuraminidase inhibitors, has encouraged identification of new target ...
Fatima U, et al. Equine Mx1 Restricts Influenza A Virus Replication by Targeting at Distinct Site of its Nucleoprotein. Viruses. 2019 Dec 2;11(12).. Abstract
submitted by kickingbird at Dec, 10, 2019 from Viruses. 2019 Dec 2;11(12). (via https://www.mdpi.com/1999-4915/11/12/1114)
Interferon-mediated host factors myxovirus (Mx) proteins are key features in regulating influenza A virus (IAV) infections. Viral polymerases are essential for viral replication. The Mx1 protein has been ...
Shehata MM, et al. A Recombinant Influenza A/H1N1 Carrying A Short Immunogenic Peptide of MERS-CoV as Bivalent Vaccine in BALB/c Mice. Pathogens. 2019 Dec 2;8(4).. Abstract
submitted by kickingbird at Dec, 10, 2019 from Pathogens. 2019 Dec 2;8(4). (via https://www.mdpi.com/2076-0817/8/4/281)
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) became a global human health threat since its first documentation in humans in 2012. An efficient vaccine for the prophylaxis of humans in hotspots ...
Van Poelvoorde LAE, Saelens X, Thomas I, Roosen NH. Next-Generation Sequencing: An Eye-Opener for the Surveillance of Antiviral Resistance in Influenza. Trends Biotechnol. 2019 Dec. Abstract
submitted by kickingbird at Dec, 10, 2019 from Trends Biotechnol. 2019 Dec (via https://www.cell.com/trends/biotechnology/fulltext/S0167-779)
Next-generation sequencing (NGS) can enable a more effective response to a wide range of communicable disease threats, such as influenza, which is one of the leading causes of human morbidity and mortality ...
van de Sandt CE, et al. Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph. Nat Commun. 2019 Dec 6;10(1):557. Abstract
submitted by kickingbird at Dec, 10, 2019 from Nat Commun. 2019 Dec 6;10(1):557 (via https://www.nature.com/articles/s41467-019-13346-4)
Although influenza viruses lead to severe illness in high-risk populations, host genetic factors associated with severe disease are largely unknown. As the HLA-A*68:01 allele can be linked to severe pandemic ...
Dellicour S, et al. Incorporating heterogeneous sampling probabilities in continuous phylogeographic inference - application to H5N1 spread in the Mekong region. Bioinformatics. 2019 Dec 2. Abstract
submitted by kickingbird at Dec, 8, 2019 from Bioinformatics. 2019 Dec 2 (via https://www.ncbi.nlm.nih.gov/pubmed/31790143)
MOTIVATION: The potentially low precision associated with the geographic origin of sampled sequences represents an important limitation for spatially-explicit (i.e. continuous) phylogeographic inference ...
Loh L, Koutsakos M, Kedzierska K, Hinks TSC. Influenza A Virus-Infected Lung Epithelial Cell Co-Culture with Human Peripheral Blood Mononuclear Cells. Methods Mol Biol. 2020;2098:141-147. Abstract
submitted by kickingbird at Dec, 8, 2019 from Methods Mol Biol. 2020;2098:141-147 (via https://www.ncbi.nlm.nih.gov/pubmed/31792820)
Sensing of influenza A virus (IAV) infection by pattern recognition receptors can occur by either direct infection of lung epithelial cells or uptake of virus-infected cells by innate cells such as dendritic ...
Pascua PNQ, et al. Influenza B viruses from different genetic backgrounds are variably impaired by neuraminidase inhibitor resistance-associated substitutions. Antiviral Res. 2019 Nov 29:104669.. Abstract
submitted by kickingbird at Dec, 7, 2019 from Antiviral Res. 2019 Nov 29:104669. (via https://www.sciencedirect.com/science/article/pii/S016635421)
Identifying evolutionary routes to antiviral resistance among influenza viruses informs molecular-based resistance surveillance and clinical decisions. To improve antiviral management and understand whether ...
Imai M, et al. Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets. Nat Microbiol. 2019 Nov 25.. Abstract
submitted by kickingbird at Dec, 7, 2019 from Nat Microbiol. 2019 Nov 25. (via https://www.nature.com/articles/s41564-019-0609-0)
Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein-a mutation that confers reduced susceptibility ...
Bogdanow B, et al. The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant. Nat Commun. 2019 Dec 4;10(1):5518. Abstract
submitted by kickingbird at Dec, 7, 2019 from Nat Commun. 2019 Dec 4;10(1):5518 (via https://www.nature.com/articles/s41467-019-13520-8)
Pandemic influenza A virus (IAV) outbreaks occur when strains from animal reservoirs acquire the ability to infect and spread among humans. The molecular basis of this species barrier is incompletely understood. ...
Zhong G, et al. Mutations in the NA-like protein of bat influenza H18N11 virus enhance virus replication in mammalian cells, mice, and ferrets. J Virol. 2019 Dec 4. Abstract
submitted by kickingbird at Dec, 7, 2019 from J Virol. 2019 Dec 4 (via https://jvi.asm.org/content/early/2019/11/28/JVI.01416-19)
To characterize bat influenza H18N11 virus, we propagated a reverse genetics-generated H18N11 virus in MDCK II cells and detected two adapting mutations in the neuraminidase (NA)-like protein (NA-F144C ...
Valesano AL, et al. Influenza B viruses exhibit lower within-host diversity than influenza A viruses in human hosts. J Virol. 2019 Dec 4. Abstract
submitted by kickingbird at Dec, 7, 2019 from J Virol. 2019 Dec 4 (via https://jvi.asm.org/content/early/2019/11/28/JVI.01710-19)
Influenza B virus undergoes seasonal antigenic drift more slowly than influenza A, but the reasons for this difference are unclear. While the evolutionary dynamics of influenza viruses play out globally, ...
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