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2019-8-25 23:08:58
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Lui WY, et al. SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection. Emerg Microbes Infect. 2019;8(1):662-674.  Abstract  
submitted by kickingbird at May, 16, 2019 from Emerg Microbes Infect. 2019;8(1):662-674 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Influenza defective interfering (DI) particles are replication-incompetent viruses carrying large internal deletion in the genome. The loss of essential genetic information causes abortive viral replication, ...

Gahan J, et al. Whole Genome Sequencing of the First H3N8 Equine Influenza Virus Identified in Malaysia. Pathogens. 2019 May 10;8(2)..  Abstract  
submitted by kickingbird at May, 16, 2019 from Pathogens. 2019 May 10;8(2). (via https://www.mdpi.com/2076-0817/8/2/62)
In August 2015, Malaysia experienced an outbreak of acute respiratory disease in racehorses. Clinical signs observed were consistent with equine influenza (EI) infection. The index cases were horses recently ...

Feldman RA, et al. mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials. Vaccine. 2019 May 9..  Abstract  
submitted by kickingbird at May, 15, 2019 from Vaccine. 2019 May 9. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
BACKGROUND: We evaluated safety and immunogenicity of the first mRNA vaccines against potentially pandemic avian H10N8 and H7N9 influenza viruses.METHODS: Two randomized, placebo-controlled, double-blind, ...

Qin C, et al. Close Relationship between cIAP2 and Human ARDS Induced by Severe H7N9 Infection. Biomed Res Int. 2019 Apr 7;2019:2121357.  Abstract  
submitted by kickingbird at May, 15, 2019 from Biomed Res Int. 2019 Apr 7;2019:2121357 (via https://www.hindawi.com/journals/bmri/2019/2121357/)
Background: cIAP2 is involved in necroptosis as a key upstream regulation factor. We aimed to investigate the role of cIAP2 in ARDS/ALI induced by H7N9 virus through regulating the RIPK1/3 necroptosis ...

Xu G, et al. Mutations in PB2 and HA enhanced pathogenicity of H4N6 avian influenza virus in mice. J Gen Virol. 2019 May 13.  Abstract  
submitted by kickingbird at May, 15, 2019 from J Gen Virol. 2019 May 13 (via https://jgv.microbiologyresearch.org/content/journal/jgv/10.)
The H4 subtype avian influenza virus (AIV) continues to circulate in both wild birds and poultry, and occasionally infects mammals (e.g. pigs). H4-specific antibodies have also been detected in poultry ...

Luo W, et al. The codon usage bias of avian influenza A viruses. J Infect. 2019 May 7. pii: S0163-4453(19)30131-8..  Abstract  
submitted by kickingbird at May, 12, 2019 from J Infect. 2019 May 7. pii: S0163-4453(19)30131-8. (via https://www.journalofinfection.com/article/S0163-4453(19)301)
A recent study in this journal revealed that avian influenza A viruses (AIVs) H5Nx (N1, N6 and N8) showed pathogenicity,1 and accordingly had different adaptation to the codon usage pattern of its hosts.2 ...

Nguyen ATV, et al. Peptide Aptamer of Complementarity-determining Region to Detect Avian Influenza Virus. J Biomed Nanotechnol. 2019 Jun 1;15(6):1185-1200.  Abstract  
submitted by kickingbird at May, 12, 2019 from J Biomed Nanotechnol. 2019 Jun 1;15(6):1185-1200 (via https://www.ingentaconnect.com/content/asp/jbn/2019/00000015)
Despite significant progress in the development of diagnostic methods for influenza, avian influenza (AI) infection continues to represent a substantial threat to human health. Among the subtypes of AI, ...

Ashraf U, et al. Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy. PNAS 2019 May 10.  Abstract  
submitted by kickingbird at May, 12, 2019 from PNAS 2019 May 10 (via https://www.pnas.org/content/early/2019/05/09/1901214116)
New therapeutic strategies targeting influenza are actively sought due to limitations in current drugs available. Host-directed therapy is an emerging concept to target host functions involved in pathogen ...

Rigby RE, Wise HM, Smith N, Digard P, Rehwinkel J. PA-X antagonises MAVS-dependent accumulation of early type I interferon messenger RNAs during influenza A virus infection. Sci Rep. 2019 May 10;9(1):7216..  Abstract  
submitted by kickingbird at May, 12, 2019 from Sci Rep. 2019 May 10;9(1):7216. (via https://www.nature.com/articles/s41598-019-43632-6)
The sensing of viral nucleic acids by the innate immune system activates a potent antiviral response in the infected cell, a key component of which is the expression of genes encoding type I interferons ...

Russell AB, et al. Single-cell virus sequencing of influenza infections that trigger innate immunity. J Virol. 2019 May 8.  Abstract  
submitted by kickingbird at May, 12, 2019 from J Virol. 2019 May 8 (via https://www.ncbi.nlm.nih.gov/pubmed/31068418)
Influenza-infected cells vary widely in their expression of viral genes, and only occasionally activate innate immunity. Here we develop a new method to assess how the genetic variation in viral populations ...

Muscatello DJ, Leong RNF, Turner RM, Newall A. Rapid mapping of the spatial and temporal intensity of influenza. Eur J Clin Microbiol Infect Dis. 2019 May 8.  Abstract  
submitted by kickingbird at May, 12, 2019 from Eur J Clin Microbiol Infect Dis. 2019 May 8 (via https://www.ncbi.nlm.nih.gov/pubmed/31069558)
Surveillance of influenza epidemics is a priority for risk assessment and pandemic preparedness, yet representation of their spatiotemporal intensity remains limited. Using the epidemic of influenza type ...

Mine J, et al. Genetics and pathogenicity of H5N6 highly pathogenic avian influenza viruses isolated from wild birds and a chicken in Japan during winter 2017~2018. Virology. 2019 May 2;533:1-11..  Abstract  
submitted by kickingbird at May, 12, 2019 from Virology. 2019 May 2;533:1-11. (via https://www.ncbi.nlm.nih.gov/pubmed/31071540)
An H5N6 highly pathogenic avian influenza virus (HPAIV) outbreak occurred in poultry in Japan during January 2018, and H5N6 HPAIVs killed several wild birds in 3 prefectures during Winter 2017~2018. Time-measured ...

Scheibner D, et al. Virulence of three European highly pathogenic H7N1 and H7N7 avian influenza viruses in Pekin and Muscovy ducks. BMC Vet Res. 2019 May 10;15(1):142..  Abstract  
submitted by kickingbird at May, 12, 2019 from BMC Vet Res. 2019 May 10;15(1):142. (via https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-)
BACKGROUND: There is paucity of data on the virulence of highly pathogenic (HP) avian influenza viruses (AIV) H7 in ducks compared to HPAIV H5. Here, the virulence of HPAIV H7N1 (designated H7N1-FPV34 ...

Bonomo ME, Kim RY, Deem MW. Modular epitope binding predicts influenza quasispecies dominance and vaccine effectiveness: Application to 2018/19 season. Vaccine. 2019 May 3. pii: S0264-410X(19)30417-7..  Abstract  
submitted by kickingbird at May, 10, 2019 from Vaccine. 2019 May 3. pii: S0264-410X(19)30417-7. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
The modular binding sites on the influenza A(H3N2) hemagglutinin protein are under significant pressure to acquire mutations in order to evade human antibody recognition. Analysis of these hemagglutinin ...

Bao J, et al. Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus. J Immunol Res. 2019 Apr 2;2019:1418251.  Abstract  
submitted by kickingbird at May, 10, 2019 from J Immunol Res. 2019 Apr 2;2019:1418251 (via https://www.hindawi.com/journals/jir/2019/1418251/)
The outbreak of avian influenza A (H7N9) virus infection, with a high mortality rate, has caused concern worldwide. Although interleukin-17- (IL-17-) secreting CD4+ T (Th17) and CD8+ T (Tc17) cells have ...

Fernandes-Matano L, et al. Analysis of influenza data generated by four epidemiological surveillance laboratories in Mexico, 2010~2016. Epidemiol Infect. 2019 Jan;147:e183..  Abstract  
submitted by kickingbird at May, 10, 2019 from Epidemiol Infect. 2019 Jan;147:e183. (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
The disease caused by the influenza virus is a global public health problem due to its high rates of morbidity and mortality. Thus, analysis of the information generated by epidemiological surveillance ...

Yip L, et al. Influenza virus RNA recovered from droplets and droplet nuclei emitted by adults in an acute care setting. J Occup Environ Hyg. 2019 May 3:1-8..  Abstract  
submitted by kickingbird at May, 8, 2019 from J Occup Environ Hyg. 2019 May 3:1-8. (via https://www.tandfonline.com/doi/abs/10.1080/15459624.2019.15)
Transmission in hospital settings of seasonal influenza viruses and novel agents such as the Middle East respiratory syndrome coronavirus (MERS-CoV) is well-described but poorly understood. The characterization ...

Zhu L, et al. Influenza virus matrix protein M1 interacts with SLD5 to block host cell cycle. Cell Microbiol. 2019 May 3:e13038.  Abstract  
submitted by kickingbird at May, 8, 2019 from Cell Microbiol. 2019 May 3:e13038 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.13038)
Influenza virus matrix 1 protein (M1) is highly conserved and plays essential roles at many stages of virus life cycle. Here we used a yeast two-hybrid system to identify the host protein SLD5, a component ...

Zhang Y, Xu C, Zhang H, Liu GD, Xue C, Cao Y. Targeting Hemagglutinin: Approaches for Broad Protection against the Influenza A Virus. Viruses. 2019 Apr 30;11(5)..  Abstract  
submitted by kickingbird at May, 8, 2019 from Viruses. 2019 Apr 30;11(5). (via https://www.mdpi.com/1999-4915/11/5/405)
Influenza A viruses are dynamically epidemic and genetically diverse. Due to the antigenic drift and shift of the virus, seasonal vaccines are required to be reformulated annually to match with current ...

Lee DH, et al. Intercontinental spread of Asian-origin H7 avian influenza viruses by captive bird trade in 1990´s. Infect Genet Evol. 2019 May 1..  Abstract  
submitted by kickingbird at May, 8, 2019 from Infect Genet Evol. 2019 May 1. (via https://www.sciencedirect.com/science/article/pii/S156713481)
Wild bird migration and illegal trade of infected poultry, eggs, and poultry products have been associated with the spread of avian influenza viruses (AIV). During 1992-1996, H7N1 and H7N8 low pathogenic ...

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