Zhang, L., Shao, Y., Zou, X. et al. A primary oseltamivir-resistant mutation in influenza hemagglutinin and its implications for antiviral resistance surveillance. Nat Commun (2025). Abstract
submitted by kickingbird at Dec, 12, 2025 from Nat Commun (2025) (via https://www.nature.com/articles/s41467-025-66307-5)
Oseltamivir, a neuraminidase (NA) inhibitor, is currently the most widely used antiviral drug for influenza worldwide. The emergence of primary oseltamivir-resistant mutations in NA protein of seasonally ... Higerd-Rusli GP, Karan A, Hoffman SA, Morante IEA,. One confirmed and one potential human case of influenza A(H5N1) detected through an expanded subtyping protocol. ASM Case Rep 0:e00165-25. Abstract
submitted by kickingbird at Dec, 11, 2025 from ASM Case Rep 0:e00165-25 (via https://journals.asm.org/doi/10.1128/asmcr.00165-25)
Current U.S. surveillance for highly pathogenic avian influenza A(H5N1) in humans prioritizes individuals with known animal exposures, potentially missing community-acquired infections. To address this ... Kar J, Hirohama M, Nakayama K, Lee S, Kawaguchi A. Microtubule detyrosination links inflammasome activation to apoptotic cell death in macrophages upon influenza A virus infection. J Virol. 2025 Dec 9:e0184725. Abstract
submitted by kickingbird at Dec, 11, 2025 from J Virol. 2025 Dec 9:e0184725 (via https://journals.asm.org/doi/10.1128/jvi.01847-25)
The tubulin code, defined by diverse post-translational modifications of microtubules, fine-tunes microtubule dynamics, regulating downstream cellular signaling. Among these, detyrosination of α-tubulin ... Ivan Tomic, etc.,al. [preprint]Innate antiviral readiness drives the expansion of protective T stem cell memory against influenza. https://doi.org/10.64898/2025.12.06.692757. Abstract
submitted by kickingbird at Dec, 11, 2025 from https://doi.org/10.64898/2025.12.06.692757 (via https://www.biorxiv.org/content/10.64898/2025.12.06.692757v1)
The development of T-cell-based influenza vaccines relies on eliciting broad CD8+ T-cell immunity, wherein T stem cell-like memory (TSCM) cells serve as the ultimate long-lived reservoir for immune memory, ... Matteo Chiara, etc.,al. [preprint]Distinctive viral genome signatures are linked to repeated mammalian spillovers of H5N1 in North America. https://doi.org/10.64898/2025.12.09.693147. Abstract
submitted by kickingbird at Dec, 10, 2025 from https://doi.org/10.64898/2025.12.09.693147 (via https://www.biorxiv.org/content/10.64898/2025.12.09.693147v1)
Highly pathogenic avian influenza H5N1 rarely infects mammals. In 2024-2025, however, genotypes B3.13 and D1.1 caused two independent spillovers into U.S. dairy cattle. By analysing 26,930 complete H5N1 ... Wang X, Liu X, Wang S, Wang Q, Wang J, Wang M, Yao. Identification of the Key Amino Acid Mutations in the PB2 and PA Proteins of Classical Swine H1N1 Influenza A Virus in Mammalian Adaptation. Emerg Microbes Infect. 2025 Dec 9:2602310. Abstract
submitted by kickingbird at Dec, 10, 2025 from Emerg Microbes Infect. 2025 Dec 9:2602310 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
The classical swine (CS) H1N1 influenza virus firstly isolated in 1930 is highly homologous to the 1918 Spanish influenza virus. CS H1N1 virus crossed the interspecies barrier to infect humans has become ... Richard A. Neher, etc.,al. [preprint]Nomenclature for tracking of genetic variation of seasonal influenza viruses. https://doi.org/10.64898/2025.12.06.25341755. Abstract
submitted by kickingbird at Dec, 9, 2025 from https://doi.org/10.64898/2025.12.06.25341755 (via https://www.medrxiv.org/content/10.64898/2025.12.06.25341755)
Background: Genomic surveillance of human seasonal influenza viruses is an essential component of the Global Influenza Surveillance and Response system (GISRS) and informs the recommendations for the seasonal ... Li, ZN., Liu, F., Jung, YJ. et al. Pre-existing cross-reactive immunity to highly pathogenic avian influenza 2.3.4.4b A(H5N1) virus in the United States. Nat Commun 16, 10954 (2025). Abstract
submitted by kickingbird at Dec, 9, 2025 from Nat Commun 16, 10954 (2025) (via https://link.springer.com/article/10.1038/s41467-025-66431-2)
The unprecedented 2.3.4.4b. A(H5N1) outbreak in dairy cattle, poultry, and spillover to humans in the United States (US) poses a major public health threat. Population immunity is a critical component ... Son, SE., An, SH., Lee, CY. et al. Evolutionary trajectories and zoonotic potential of a PB2 mutation triad (I147T, K339T, and A588T) in avian influenza viruses. Vet Res (2025). Abstract
submitted by kickingbird at Dec, 9, 2025 from Vet Res (2025) (via https://link.springer.com/article/10.1186/s13567-025-01680-z)
Efficient replication of influenza A viruses (IAVs) requires balanced activities of hemagglutinin (HA), neuraminidase (NA), and the RNA polymerase complex, whose functions are strongly influenced by PB2 ... Agustina Rimondi, etc.,al. [preprint]Persistence and spillback of mammal-adapted H5N1 genotype B3.2 viruses among South American seabirds and marine mammals. https://doi.org/10.21203/rs.3.rs-7960151/v1. Abstract
submitted by kickingbird at Dec, 8, 2025 from https://doi.org/10.21203/rs.3.rs-7960151/v1 (via https://www.researchsquare.com/article/rs-7960151/v1)
The arrival of H5N1 clade 2.3.4.4b genotype B3.2 in South America marks an unprecedented geographic expansion of highly pathogenic avian influenza viruses. The continent remains the only region with sustained ... Hu J, Li J, You W, Liu L, Chen H. Disruption of the local vRNA structure at the end of HA encoding region interferes with the selective packaging of influenza A virus genome. Biochem Biophys Res Commun. 2025 Dec 3;795:153082. Abstract
submitted by kickingbird at Dec, 8, 2025 from Biochem Biophys Res Commun. 2025 Dec 3;795:153082 (via https://www.sciencedirect.com/science/article/abs/pii/S00062)
Influenza A virus (IAV) selectively packages eight distinct viral RNA (vRNA) segments into progeny virions through segment-specific packaging signals located in the noncoding regions and their adjacent ... Jin Y, Cui H, Jiang L, et al. From Surfaces to Spillover: Environmental Persistence and Indirect Transmission of Influenza A(H3N8) Virus. Microorganisms. 2025; 13(12):2782. Abstract
submitted by kickingbird at Dec, 7, 2025 from Microorganisms. 2025; 13(12):2782 (via https://www.mdpi.com/2076-2607/13/12/2782)
Avian influenza viruses (AIVs) pose a significant zoonotic threat, with the emerging H3N8 subtype raising increasing concern due to sporadic human infections. Current strategies for risk assessment of ... Liedes, O., Reinholm, A., Ekstr?m, N. et al. Influenza A(H5N8) vaccine induces humoral and cell-mediated immunity against highly pathogenic avian influenza clade 2.3.4.4b A(H5N1) viruses in at-risk individuals. Nat Microbiol (2025). Abstract
submitted by kickingbird at Dec, 6, 2025 from Nat Microbiol (2025) (via https://www.nature.com/articles/s41564-025-02183-5)
Finland faced an outbreak of highly pathogenic clade 2.3.4.4b A(H5N1) avian influenza in 2023, which spread from wild birds to fur farms. Vaccinations of at-risk individuals began in June 2024 using the ... Kephart, S.M., Awatramani, K.F., Saunders, M.I. et. Host switching mutations in H5N1 influenza hemagglutinin suppress site-specific activation dynamics. Nat Commun (2025). Abstract
submitted by kickingbird at Dec, 6, 2025 from Nat Commun (2025) (via https://link.springer.com/article/10.1038/s41467-025-66926-y)
Increase in human H5N1 spillover infections resulting from dissemination of highly pathogenic avian influenza (HPAI) virus into bird and mammal populations raises concerns about HPAI gaining human transmissibility. ... Saubi N, Andrés C, Prats-Méndez I, González-Sánche. Expansion of influenza A(H1N1)pdm09 NA:S247N viruses with reduced susceptibility to oseltamivir, Catalonia, Spain, and in Europe, July to October 2025. Euro Surveill. 2025 Dec;30(48). Abstract
submitted by kickingbird at Dec, 6, 2025 from Euro Surveill. 2025 Dec;30(48) (via https://www.eurosurveillance.org/content/10.2807/1560-7917.E)
Between July and October 2025, among the total 117 influenza A(H1N1)pdm09 strains characterised in Catalonia, 20% to 100% per week were carrying the NA:S247N substitution. The mutation, conferring reduced ... Matyszewska D, Kapu?cińska M, Fontaine P. Elucidating the nature of the interactions of oseltamivir with the 2D model of influenza A virus lipid envelope. Colloids Surf B Biointerfaces. 2025 Nov 29;259:115. Abstract
submitted by kickingbird at Dec, 6, 2025 from Colloids Surf B Biointerfaces. 2025 Nov 29;259:115 (via https://www.sciencedirect.com/science/article/pii/S092777652)
This study investigates the molecular interactions of the antiviral agent oseltamivir phosphate (OSL) with a two-dimensional (2D) Langmuir monolayer model of the influenza A (AH1N1) virus lipid envelope. ... Qian Zhang, etc.,al. Autoantibodies neutralizing type I IFNs in a fatal case of H5N1 avian influenza. J Exp Med 2 March 2026; 223 (3): e20251962. Abstract
submitted by kickingbird at Dec, 6, 2025 from J Exp Med 2 March 2026; 223 (3): e20251962 (via https://rupress.org/jem/article/223/3/e20251962/278557/Autoa)
Avian influenza A virus (IAV) H5N1 is an emerging threat of human pandemic. We describe a 71-year-old man who died of H5N1 pneumonia in Louisiana and whose blood contained autoantibodies neutralizing type ... An Y, Ding X, Tian Y, Zhang M, Ma Y, Wu X, Cai M,. High-throughput pseudovirus neutralisation maps the antigenic landscape of influenza A/H1N1 viruses. EBioMedicine. 2025 Dec 2;122:106047. Abstract
submitted by kickingbird at Dec, 5, 2025 from EBioMedicine. 2025 Dec 2;122:106047 (via https://www.thelancet.com/journals/ebiom/article/PIIS2352-39)
Background: The continuous mutations in the haemagglutinin gene in A/H1N1 influenza viruses drives antigenic drift, necessitating frequent vaccine updates. Pseudovirus systems, with their flexible HA protein ... Huddleston J, Bedford T. Timely vaccine strain selection and genomic surveillance improve evolutionary forecast accuracy of seasonal influenza A/H3N2. Elife. 2025 Dec 4;14:RP104282. Abstract
submitted by kickingbird at Dec, 5, 2025 from Elife. 2025 Dec 4;14:RP104282 (via https://elifesciences.org/articles/104282)
Evolutionary forecasting models inform seasonal influenza vaccine design by predicting which current genetic variants will dominate in the influenza season 12 months later. Forecasting models depend on ... Guan L, etc., al. Stability of Avian Influenza A(H5N1) Virus in Milk from Infected Cows and Virus-Spiked Milk. N Engl J Med . 2025 Dec 4;393(22):2271-2273. Abstract
submitted by kickingbird at Dec, 4, 2025 from N Engl J Med . 2025 Dec 4;393(22):2271-2273 (via https://www.nejm.org/doi/10.1056/NEJMc2502494)
In March 2024, public health agencies in the United States reported highly pathogenic avian influenza (HPAI) virus of subtype A(H5N1) in dairy cattle, with virus detected in milk samples from symptomatic ... 6625 items, 20/Page, Page[8/332][|<<] [|<] [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [>|] [>>|] |
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