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2020-5-25 5:19:06
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Wu NC, Wilson IA. Influenza Hemagglutinin Structures and Antibody Recognition. Cold Spring Harb Perspect Med. 2019 Dec 23.  Full Text  
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23 (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
Hemagglutinin (HA) is most abundant glycoprotein on the influenza virus surface. Influenza HA promotes viral entry by engaging the receptor and mediating virus-host membrane fusion. At the same time, HA ...

Wille M, Holmes EC. The Ecology and Evolution of Influenza Viruses. Cold Spring Harb Perspect Med. 2019 Dec 23.  Full Text  
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23 (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
The patterns and processes of influenza virus evolution are of fundamental importance, underpinning such traits as the propensity to emerge in new host species and the ability to rapidly generate antigenic ...

Johnson KEE, Ghedin E. Quantifying between-Host Transmission in Influenza Virus Infections. Cold Spring Harb Perspect Med. 2019 Dec 23..  Full Text  
submitted by kickingbird at Dec, 26, 2019 from Cold Spring Harb Perspect Med. 2019 Dec 23. (via http://perspectivesinmedicine.cshlp.org/content/early/2019/1)
The error-prone replication and life cycle of influenza virus generate a diverse set of genetic variants. Transmission between hosts strictly limits both the number of virus particles and the genetic diversity ...

Gadalla MR, Abrami L, van der Goot FG, Veit M. Hemagglutinin of Influenza A, but not of Influenza B and C viruses is acylated by ZDHHC2, 8, 15 and 20. Biochem J. 2019 Dec 24.  Abstract  
submitted by kickingbird at Dec, 26, 2019 from Biochem J. 2019 Dec 24 (via https://portlandpress.com/biochemj/article/doi/10.1042/BCJ20)
Hemagglutinin (HA), a glycoprotein of Influenza A viruses and its proton-channel M2 are site-specifically modified with fatty acids. Whereas two cysteines in the short cytoplasmic tail of HA contain only ...

Baranovskaya I, et al. Changes in RNA secondary structure affect NS1 protein expression during early stage influenza virus infection. Virol J. 2019 Dec 21;16(1):162..  Abstract  
submitted by kickingbird at Dec, 23, 2019 from Virol J. 2019 Dec 21;16(1):162. (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
RNA secondary structures play a key role in splicing, gene expression, microRNA biogenesis, RNA editing, and other biological processes. The importance of RNA structures has been demonstrated in the life ...

Yao L, et al. Persistence of H7N9 virus antibody response 2 years after infection. Influenza Other Respir Viruses. 2019 Dec 19..  Abstract  
submitted by kickingbird at Dec, 21, 2019 from Influenza Other Respir Viruses. 2019 Dec 19. (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12702)
We measured antibodies against H7N9 virus 2 years after infection in 14 patients who were infected during October 2016-September 2017. Approximately 2 years after infection, antibody titers ≥10 were detectable ...

Jiang W, et al. Antigenic Variant of Highly Pathogenic Avian Influenza A(H7N9) Virus, China, 2019. Emerg Infect Dis. 2020 Feb 17;26(2).  Abstract  
submitted by kickingbird at Dec, 21, 2019 from Emerg Infect Dis. 2020 Feb 17;26(2) (via https://wwwnc.cdc.gov/eid/article/26/2/19-1105_article)
In China, influenza A(H7N9) virus appeared in 2013, then mutated into a highly pathogenic virus, causing outbreaks among poultry and cases in humans. Since September 2017, extensive use of the corresponding ...

Murakami S, et al. Influenza D Virus of New Phylogenetic Lineage, Japan. Emerg Infect Dis. 2020 Jan;26(1):168-171..  Abstract  
submitted by kickingbird at Dec, 21, 2019 from Emerg Infect Dis. 2020 Jan;26(1):168-171. (via https://wwwnc.cdc.gov/eid/article/26/1/19-1092_article)
Influenza D virus (IDV) can potentially cause respiratory diseases in livestock. We isolated a new IDV strain from diseased cattle in Japan; this strain is phylogenetically and antigenically distinguished ...

Tepper V, et al. Influenza A/H4N2 mallard infection experiments further indicate zanamivir as less prone to induce environmental resistance development than oseltamivir. J Gen Virol. 2019 Dec 19.  Abstract  
submitted by kickingbird at Dec, 21, 2019 from J Gen Virol. 2019 Dec 19 (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Neuraminidase inhibitors (NAIs) are the gold standard treatment for influenza A virus (IAV). Oseltamivir is mostly used, followed by zanamivir (ZA). NAIs are not readily degraded in conventional wastewater ...

Jia R, Liu S, Xu J, Liang X. IL16 deficiency enhances Th1 and cytotoxic T lymphocyte response against influenza A virus infection. Biosci Trends. 2019 Dec 18.  Abstract  
submitted by kickingbird at Dec, 21, 2019 from Biosci Trends. 2019 Dec 18 (via https://www.jstage.jst.go.jp/article/bst/advpub/0/advpub_201)
Influenza A virus (IAV) is the major cause of seasonal epidemics and flu outbreaks worldwide. Given that interleukin 16 (IL16) can regulate T cell function and is one of the signature markers for virus ...

Mu?oz-Moreno R, et al. Viral Fitness Landscapes in Diverse Host Species Reveal Multiple Evolutionary Lines for the NS1 Gene of Influenza A Viruses. Cell Rep. 2019 Dec 17;29(12):3997-4009.e5..  Abstract  
submitted by kickingbird at Dec, 21, 2019 from Cell Rep. 2019 Dec 17;29(12):3997-4009.e5. (via https://www.cell.com/cell-reports/fulltext/S2211-1247(19)315)
Influenza A viruses (IAVs) have a remarkable tropism in their ability to circulate in both mammalian and avian species. The IAV NS1 protein is a multifunctional virulence factor that inhibits the type ...

Mohamed W, Ito K, Omori R. Estimating Transmission Potential of H5N1 Viruses Among Humans in Egypt Using Phylogeny, Genetic Distance and Sampling Time Interval. Front Microbiol. 2019 Dec 3;10:2765.  Abstract  
submitted by kickingbird at Dec, 21, 2019 from Front Microbiol. 2019 Dec 3;10:2765 (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0276)
In 2014 and 2015, the number of human cases of H5N1 avian influenza virus infections had increased dramatically in Egypt. This increase might be related to increase in the transmission potential of the ...

Li G, et al. Insulin-Like Growth Factor 1 Regulates Acute Inflammatory Lung Injury Mediated by Influenza Virus Infection. Front Microbiol. 2019 Nov 26;10:2541..  Abstract  
submitted by kickingbird at Dec, 21, 2019 from Front Microbiol. 2019 Nov 26;10:2541. (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0254)
The acute inflammatory lung injury is an important cause of death due to influenza A virus (IAV) infection. Insulin-like growth factor 1 (IGF1) played an important role in the regulation of inflammation ...

Kuwahara T, Yamayoshi S, Noda T, Kawaoka Y. G Protein Pathway Suppressor 1 Promotes Influenza Virus Polymerase Activity by Activating the NF-κB Signaling Pathway. MBio. 2019 Dec 17;10(6). pii: e02867-19..  Abstract  
submitted by kickingbird at Dec, 21, 2019 from MBio. 2019 Dec 17;10(6). pii: e02867-19. (via https://mbio.asm.org/content/10/6/e02867-19)
Influenza virus relies heavily on cellular machinery to replicate in host cells. Therefore, to better understand the influenza virus life cycle, it is important to identify which host proteins are involved ...

Konstantinidi A, et al. The boundary lipid around DMPC-spanning influenza A M2 transmembrane domain channels: Its structure and potential for drug accommodation. Biochim Biophys Acta Biomembr. 2019 Dec 14:183156..  Abstract  
submitted by kickingbird at Dec, 21, 2019 from Biochim Biophys Acta Biomembr. 2019 Dec 14:183156. (via https://www.sciencedirect.com/science/article/pii/S000527361)
We have investigated the perturbation of influenza A M2TM in DMPC bilayers. We have shown that (a) DSC and SAXS detect changes in membrane organization caused by small changes (micromolar) in M2TM or aminoadamantane ...

Jureka AS, et al. The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I. J Biol Chem. 2019 Dec 16..  Abstract  
submitted by kickingbird at Dec, 21, 2019 from J Biol Chem. 2019 Dec 16. (via http://www.jbc.org/content/early/2019/12/16/jbc.RA119.011410)
A critical role of the influenza A virus non-structural protein 1 (NS1) is to antagonize the host cellular antiviral response. NS1 accomplishes this role through numerous interactions with host proteins ...

McCarthy KR, et al. Affinity maturation in a human humoral response to influenza hemagglutinin. PNAS 2019 Dec 16.  Abstract  
submitted by kickingbird at Dec, 21, 2019 from PNAS 2019 Dec 16 (via https://www.ncbi.nlm.nih.gov/pubmed/31843892)
Affinity maturation of the B cell antigen receptor (BCR) is a conserved and crucial component of the adaptive immune response. BCR lineages, inferred from paired heavy- and light-chain sequences of rearranged ...

Nickbakhsh S, et al. Virus-virus interactions impact the population dynamics of influenza and the common cold. PNAS 2019 Dec 16.  Abstract  
submitted by kickingbird at Dec, 21, 2019 from PNAS 2019 Dec 16 (via https://www.pnas.org/content/early/2019/12/10/1911083116)
The human respiratory tract hosts a diverse community of cocirculating viruses that are responsible for acute respiratory infections. This shared niche provides the opportunity for virus-virus interactions ...

Virk RK, et al. Divergent evolutionary trajectories of influenza B viruses underlie their contemporaneous epidemic activity. PNAS 2019 Dec 16.  Abstract  
submitted by kickingbird at Dec, 21, 2019 from PNAS 2019 Dec 16 (via https://www.pnas.org/content/early/2019/12/13/1916585116)
Influenza B viruses have circulated in humans for over 80 y, causing a significant disease burden. Two antigenically distinct lineages ("B/Victoria/2/87-like" and "B/Yamagata/16/88-like," termed Victoria ...

de Vries RD, et al. Analysis Of The Vaccine-Induced Influenza B Virus Hemagglutinin-Specific Antibody Dependent Cellular Cytotoxicity Response. Virus Res. 2019 Dec 11:197839..  Abstract  
submitted by kickingbird at Dec, 16, 2019 from Virus Res. 2019 Dec 11:197839. (via https://www.ncbi.nlm.nih.gov/pubmed/31837382)
Influenza A virus (IAV) and influenza B virus (IBV) cause substantial morbidity and mortality during seasonal epidemics. On basis of variation in the surface glycoprotein hemagglutinin, two antigenically ...

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