Coombs KM, et al. Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses. Viruses. 2019 Nov 5;11(11).. Abstract
submitted by kickingbird at Nov, 11, 2019 from Viruses. 2019 Nov 5;11(11). (via https://www.mdpi.com/1999-4915/11/11/1028)
Influenza A viruses (IAVs) are important animal and human emerging and re-emerging pathogens that are responsible for yearly seasonal epidemics and sporadic pandemics. IAVs cause a wide range of clinical ...
Gambaryan AS, et al. Changes in the Receptor-Binding Properties of H3N2 Viruses during Long-Term Circulation in Humans. Biochemistry (Mosc). 2019 Oct;84(10):1177-1185. Abstract
submitted by kickingbird at Nov, 11, 2019 from Biochemistry (Mosc). 2019 Oct;84(10):1177-1185 (via https://www.ncbi.nlm.nih.gov/pubmed/31694513)
It was previously shown that hemagglutinin residues Thr155, Glu158, and Ser228 are crucial for the recognition of Neu5Gc. In this study, we demonstrated that the ability to bind the Neu5Gc-terminated receptor ...
Brown JC, Barclay WS, Galiano M, Harvey R. Passage of influenza A/H3N2 viruses in human airway cells removes artefactual variants associated with neuraminidase-mediated binding. J Gen Virol. 2019 Nov 8.. Abstract
submitted by kickingbird at Nov, 11, 2019 from J Gen Virol. 2019 Nov 8. (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Serological assays with modern influenza A/H3N2 viruses have become problematic due to the progressive reduction in the ability of viruses of this subtype to bind and agglutinate red blood cells (RBCs). ...
Chen F, Liu T, Xu J, Huang Y, Liu S, Yang J. Key amino acid residues of neuraminidase involved in influenza A virus entry. Pathog Dis. 2019 Nov 8.. Abstract
submitted by kickingbird at Nov, 11, 2019 from Pathog Dis. 2019 Nov 8. (via https://academic.oup.com/femspd/advance-article-abstract/doi)
Generally, influenza virus neuraminidase (NA) plays a critical role in the release stage of influenza virus. Recently, it has been found that NA may promote influenza virus to access the target cells. ...
Tapia F, Laske T, Wasik MA, Rammhold M, Genzel Y. Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times-Insights From qPCR Measurements and Viral Dynamics Modeling. Front Bioeng Biotechnol. 2019 Oct 18;7:275. Abstract
submitted by kickingbird at Nov, 7, 2019 from Front Bioeng Biotechnol. 2019 Oct 18;7:275 (via https://www.frontiersin.org/articles/10.3389/fbioe.2019.0027)
Defective interfering particles (DIPs) are a natural byproduct of influenza A virus (IAV) replication. DIPs interfere with the propagation and spread of infectious standard virus (STV), reduce virus yields ...
Zhang F, et al. Phenotypic Characterization of Chinese Rhesus Macaque Plasmablasts for Cloning Antigen-Specific Monoclonal Antibodies. Front Immunol. 2019 Oct 11;10:2426. Abstract
submitted by kickingbird at Nov, 7, 2019 from Front Immunol. 2019 Oct 11;10:2426 (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0242)
Rhesus macaques (Macaca mulatta) are used as a human-relevant animal species for the evaluation of vaccines and as a source for cloning monoclonal antibodies (mAbs) that are highly similar to human-derived ...
Li J, Zhang K, Fan W, Zhang S, Li Y, Gu J, Zhou J,. Transcriptome Profiling Reveals Differential Effect of Interleukin-17A Upon Influenza Virus Infection in Human Cells. Front Microbiol. 2019 Oct 10;10:2344.. Abstract
submitted by kickingbird at Nov, 7, 2019 from Front Microbiol. 2019 Oct 10;10:2344. (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0234)
Influenza A virus (IAV) has developed elegant strategies to utilize cellular proteins and pathways to promote replication and evade the host antiviral response. Identification of these sabotaged host factors ...
Yang J, Li H, Jia L, Lan X, Zhao Y, Bian H, Li Z. High expression levels of influenza virus receptors in airway of the HBV-transgenic mice. Epidemiol Infect. 2019 Nov 4;147:e297.. Abstract
submitted by kickingbird at Nov, 7, 2019 from Epidemiol Infect. 2019 Nov 4;147:e297. (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
In the human population, influenza A viruses are associated with acute respiratory illness and are responsible for millions of deaths annually. Avian and human influenza viruses typically have a different ...
Ampomah PB, Lim LHK. Influenza A virus-induced apoptosis and virus propagation. Apoptosis. 2019 Oct 30. Abstract
submitted by kickingbird at Nov, 3, 2019 from Apoptosis. 2019 Oct 30 (via https://www.ncbi.nlm.nih.gov/pubmed/31667646)
Influenza A viruses (IAVs) are respiratory pathogens that cause severe morbidity and mortality worldwide. They affect cellular processes such as proliferation, protein synthesis, autophagy, and apoptosis. ...
Stadlbauer D, et al. Broadly protective human antibodies that target the active site of influenza virus neuraminidase. Science. 2019 Oct 25;366(6464):499-504.. Abstract
submitted by kickingbird at Oct, 29, 2019 from Science. 2019 Oct 25;366(6464):499-504. (via https://science.sciencemag.org/content/366/6464/499)
Better vaccines against influenza virus are urgently needed to provide broader protection against diverse strains, subtypes, and types. Such efforts are assisted by the identification of novel broadly ...
Wu L, et al. Characterization of H7N9 avian influenza viruses isolated from duck meat products. Transbound Emerg Dis. 2019 Oct 25.. Abstract
submitted by kickingbird at Oct, 29, 2019 from Transbound Emerg Dis. 2019 Oct 25. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13398)
Avian influenza H7N9 viruses have caused five epidemic waves of human infections since the first human cases were reported in 2013. In 2016, the initial low pathogenic avian influenza (LPAI) H7N9 viruses ...
Harada Y, et al. Comparison of suspension MDCK cells, adherent MDCK cells, and LLC-MK2 cells for selective isolation of influenza viruses to be used as vaccine seeds. Influenza Other Respir Viruses. 2019 Oct 25.. Abstract
submitted by kickingbird at Oct, 29, 2019 from Influenza Other Respir Viruses. 2019 Oct 25. (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12694)
BACKGROUND: Cell-based influenza vaccines can solve the problem of the frequent occurrence of egg adaptation-associated antigenic changes observed in egg-based vaccines. Seed viruses for cell-based vaccines ...
Matsuzawa Y, et al. Antigenic Change in Human Influenza A(H2N2) Viruses Detected by Using Human Plasma from Aged and Younger Adult Individuals. Viruses. 2019 Oct 23;11(11).. Abstract
submitted by kickingbird at Oct, 29, 2019 from Viruses. 2019 Oct 23;11(11). (via https://www.mdpi.com/1999-4915/11/11/978)
Human influenza A(H2N2) viruses emerged in 1957 and were replaced by A(H3N2) viruses in 1968. The antigenicity of human H2N2 viruses has been tested by using ferret antisera or mouse and human monoclonal ...
Belser JA, et al. A guide for the use of the ferret model for influenza virus infection. Am J Pathol. 2019 Oct 22.. Abstract
submitted by kickingbird at Oct, 29, 2019 from Am J Pathol. 2019 Oct 22. (via https://www.ncbi.nlm.nih.gov/pubmed/31654637)
As influenza viruses continue to jump species barriers to cause human infection, assessments of disease severity and viral replication kinetics in vivo provide crucial information for public health professionals. ...
Lee S, et al. Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium. Sci Immunol. 2019 Oct 25;4(40).. Abstract
submitted by kickingbird at Oct, 29, 2019 from Sci Immunol. 2019 Oct 25;4(40). (via https://immunology.sciencemag.org/content/4/40/eaau4643)
The respiratory epithelium is exposed to the environment and initiates inflammatory responses to exclude pathogens. Influenza A virus (IAV) infection triggers inflammatory responses in the respiratory ...
Toots M, et al. Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci Transl Med. 2019 Oct 23;11(515).. Abstract
submitted by kickingbird at Oct, 27, 2019 from Sci Transl Med. 2019 Oct 23;11(515). (via https://stm.sciencemag.org/content/11/515/eaax5866)
Influenza viruses constitute a major health threat and economic burden globally, frequently exacerbated by preexisting or rapidly emerging resistance to antiviral therapeutics. To address the unmet need ...
Liu L, Zhang Y, Cui P, Wang C, Zeng X, Deng G. Development of a duplex TaqMan real-time RT-PCR assay for simultaneous detection of newly emerged H5N6 influenza viruses. Virol J. 2019 Oct 22;16(1):119. Abstract
submitted by kickingbird at Oct, 27, 2019 from Virol J. 2019 Oct 22;16(1):119 (via https://www.ncbi.nlm.nih.gov/pubmed/31640801)
BACKGROUND: In 2017-2018, a new highly pathogenic H5N6 avian influenza virus (AIV) variant appeared in poultry and wild birds in Asian and European countries and caused multiple outbreaks. These variant ...
Strohmeier S, Amanat F, Krammer F. Cross-Reactive Antibodies Binding to the Influenza Virus Subtype H11 Hemagglutinin. Pathogens. 2019 Oct 21;8(4).. Abstract
submitted by kickingbird at Oct, 27, 2019 from Pathogens. 2019 Oct 21;8(4). (via https://www.mdpi.com/2076-0817/8/4/199)
H11 subtype influenza viruses were isolated from a wide range of bird species and one strain also was isolated from swine. In an effort to generate reagents for a chimeric H11/1 hemagglutinin-based universal ...
Li X1,2, Chan KKY, Xu B, Lu M, Xu B. Spatial, Temporal and Genetic Dynamics Characteristics of Influenza B Viruses in China, 1973~2018. Virol Sin. 2019 Oct 21. Abstract
submitted by kickingbird at Oct, 27, 2019 from Virol Sin. 2019 Oct 21 (via https://www.ncbi.nlm.nih.gov/pubmed/31637629)
Annual influenza B virus epidemics and outbreaks cause severe influenza diseases in humans and pose a threat to public health. China is an important epidemic area of influenza B viruses. However, the spatial, ...
Kariithi HM, et al. Genetic characterization and pathogenesis of the first H9N2 low pathogenic avian influenza viruses isolated from chickens in Kenyan live bird markets. Infect Genet Evol. 2019 Oct 18:104074. Abstract
submitted by kickingbird at Oct, 23, 2019 from Infect Genet Evol. 2019 Oct 18:104074 (via https://www.sciencedirect.com/science/article/pii/S156713481)
Poultry production plays an important role in the economy and livelihoods of rural households in Kenya. As part of a surveillance program, avian influenza virus (AIV)-specific real-time RT-PCR (RRT-PCR) ...
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