Kim KH, Jung YJ, Lee Y, et al. Cross protection by inactivated recombinant influenza viruses containing chimeric hemagglutinin conjugates with a conserved neuraminidase or M2 ectodomain epitope. Virology. 2020;550:51-60. Abstract
submitted by kickingbird at Sep, 7, 2020 from Virology. 2020;550:51-60 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza virus neuraminidase (NA) contains a universally conserved epitope (NAe, NA222-230). However, no studies have reported vaccines targeting this NA conserved epitope and inducing antibodies recognizing ...
Hassan MM, El Zowalaty ME, Islam A, et al. Serological Evidence of Avian Influenza in Captive Wild Birds in a Zoo and Two Safari Parks in Bangladesh. Vet Sci. 2020;7(3):E122. Abstract
submitted by kickingbird at Sep, 7, 2020 from Vet Sci. 2020;7(3):E122 (via https://www.mdpi.com/2306-7381/7/3/122)
Avian influenza (AI) is endemic and frequently causes seasonal outbreaks in winter in Bangladesh due to high pathogenic avian influenza (HPAI) H5N1 and low pathogenic avian influenza (LPAI) H9N2. Among ...
Dawson AR, Wilson GM, Freiberger EC, Mondal A, Coo. Phosphorylation controls RNA binding and transcription by the influenza virus polymerase. PLoS Pathog. 2020;16(9):e1008841. Abstract
submitted by kickingbird at Sep, 4, 2020 from PLoS Pathog. 2020;16(9):e1008841 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
The influenza virus polymerase transcribes and replicates the viral genome. The proper timing and balance of polymerase activity is important for successful replication. Genome replication is controlled ...
Zhao S, Schuurman N, Tieke M, et al. Serological screening of influenza A virus antibodies in cats and dogs indicates frequent infection with different subtypes. J Clin Microbiol. 2020. Abstract
submitted by kickingbird at Sep, 4, 2020 from J Clin Microbiol. 2020 (via https://jcm.asm.org/content/early/2020/08/27/JCM.01689-20)
Influenza A viruses (IAVs) infect humans and a variety of other animal species. Infections with some subtypes of IAV were also reported in domestic cats and dogs. Besides animal health implications, close ...
Chia BS, Li B, Cui A, et al. Loss of the nuclear protein RTF2 enhances influenza replication. J Virol. 2020;JVI.00319-20.. Abstract
submitted by kickingbird at Sep, 4, 2020 from J Virol. 2020;JVI.00319-20. (via https://jvi.asm.org/content/early/2020/08/27/JVI.00319-20)
While hundreds of genes are induced by type I interferons, their roles in restricting the influenza life cycle remain mostly unknown. Using a loss-of-function CRISPR screen in cells pre-stimulated with ...
Haralampiev I, Prisner S, Nitzan M, et al. Selective flexible packaging pathways of the segmented genome of influenza A virus. Nat Commun. 2020;11(1):4355. Abstract
submitted by kickingbird at Sep, 1, 2020 from Nat Commun. 2020;11(1):4355 (via https://www.nature.com/articles/s41467-020-18108-1)
The genome of influenza A viruses (IAV) is encoded in eight distinct viral ribonucleoproteins (vRNPs) that consist of negative sense viral RNA (vRNA) covered by the IAV nucleoprotein. Previous studies ...
Wacquiez A, Coste F, Kut E, et al. Structure and Sequence Determinants Governing the Interactions of RNAs with Influenza A Virus Non-Structural Protein NS1. Viruses. 2020;12(9):E947. Abstract
submitted by kickingbird at Sep, 1, 2020 from Viruses. 2020;12(9):E947 (via https://www.mdpi.com/1999-4915/12/9/947)
The non-structural protein NS1 of influenza A viruses is an RNA-binding protein of which its activities in the infected cell contribute to the success of the viral cycle, notably through interferon antagonism. ...
Turner JS, Zhou JQ, Han J, et al. Human germinal centres engage memory and naive B cells after influenza vaccination. Nature. 2020;10.1038/s41586-020-2711-0. Abstract
submitted by kickingbird at Sep, 1, 2020 from Nature. 2020;10.1038/s41586-020-2711-0 (via https://www.nature.com/articles/s41586-020-2711-0)
Influenza viruses remain a major public health threat. Seasonal influenza vaccination in humans primarily stimulates pre-existing memory B cells, leading to a transient wave of circulating antibody-secreting ...
Du W, Wolfert MA, Peeters B, et al. Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin. PLoS Pathog. 2020;16(8):e1008816. Abstract
submitted by kickingbird at Aug, 31, 2020 from PLoS Pathog. 2020;16(8):e1008816 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A viruses (IAVs) cause seasonal epidemics and occasional pandemics. Most pandemics occurred upon adaptation of avian IAVs to humans. This adaptation includes a hallmark receptor-binding specificity ...
Ilyushina NA, Lee N, Lugovtsev VY, Kan A, Bovin NV. Adaptation of influenza B virus by serial passage in human airway epithelial cells. Virology. 2020;549:68-76. Abstract
submitted by kickingbird at Aug, 31, 2020 from Virology. 2020;549:68-76 (via https://pubmed.ncbi.nlm.nih.gov/32853848/)
Influenza B viruses cause seasonal epidemics and are a considerable burden to public health. To understand their adaptation capability, we examined the genetic changes that occurred following 15 serial ...
Jerry C, Stallknecht D, Leyson C, et al. Recombinant hemagglutinin glycoproteins provide insight into binding to host cells by H5 influenza viruses in wild and domestic birds. irology. 2020;550:8-20. Abstract
submitted by kickingbird at Aug, 31, 2020 from irology. 2020;550:8-20 (via https://pubmed.ncbi.nlm.nih.gov/32861143/)
Clade 126.96.36.199, H5 subtype highly pathogenic avian influenza viruses (HPAIVs) have caused devastating effects across wild and domestic bird populations. We investigated differences in the intensity and ...
Tran V, Ledwith MP, Thamamongood T, et al. Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs. Nat Microbiol. 2020;10.1038/s41564-020-0778-x. Abstract
submitted by kickingbird at Aug, 26, 2020 from Nat Microbiol. 2020;10.1038/s41564-020-0778-x (via https://www.nature.com/articles/s41564-020-0778-x)
Cells infected by influenza virus mount a large-scale antiviral response and most cells ultimately initiate cell-death pathways in an attempt to suppress viral replication. We performed a CRISPR-Cas9-knockout ...
Gu J, Gu M, Yan Y, et al. Detection of PB2 627K mutation in two highly pathogenic isolates of the H7N9 subtype influenza A virus from chickens in northern China. J Infect. 2020;S0163-4453(20)30558-2. Abstract
submitted by kickingbird at Aug, 25, 2020 from J Infect. 2020;S0163-4453(20)30558-2 (via https://pubmed.ncbi.nlm.nih.gov/32828821/)
PB2 E627K mutation of influenza A virus has been considered relevant to increased mammalian virulence and adaptation. In H7N9, the substitution is naturally confined to most human isolates and few low ...
Hopken MW, Piaggio AJ, Pabilonia KL, et al. Population genomic transformations induced by isolation of wild bird avian influenza viruses (Orthomyxoviridae) in embryonated chicken eggs. Infect Genet Evol. 2020;104505. Abstract
submitted by kickingbird at Aug, 25, 2020 from Infect Genet Evol. 2020;104505 (via https://pubmed.ncbi.nlm.nih.gov/32827730/)
Isolation and cultivation of wild-type viruses in model organism cells or tissues is standard practice in virology. Oftentimes, the virus host species is distantly related to the species from which the ...
Nilsson K, Abdurahman S, Schwartz S. Influenza virus natural sequence heterogeneity in segment 8 affects interactions with cellular RNA-binding proteins and splicing efficiency. Virology. 2020;549:39-50. Abstract
submitted by kickingbird at Aug, 25, 2020 from Virology. 2020;549:39-50 (via https://pubmed.ncbi.nlm.nih.gov/32829114/)
Segment 8 mRNAs of influenza virus A/Brevig Misson/1918/1 (H1N1) are poorly spliced compared to segment 8 mRNAs of influenza virus A/Netherlands/178/95 (H3N2). Using oligonucleotide-mediated protein pull ...
Asadi S, Gaaloul Ben Hnia N, Barre RS, Wexler AS,. Influenza A virus is transmissible via aerosolized fomites. Nat Commun. 2020;11(1):4062.. Abstract
submitted by kickingbird at Aug, 21, 2020 from Nat Commun. 2020;11(1):4062. (via https://www.nature.com/articles/s41467-020-17888-w)
Influenza viruses are presumed, but not conclusively known, to spread among humans by several possible routes. We provide evidence of a mode of transmission seldom considered for influenza: airborne virus ...
Xie J, Pang XL, Tarr GAM, et al. Influenza virus detection in the stool of children with acute gastroenteritis. J Clin Virol. 2020;131:104565. Abstract
submitted by kickingbird at Aug, 21, 2020 from J Clin Virol. 2020;131:104565 (via https://pubmed.ncbi.nlm.nih.gov/32810839/)
Objectives: To determine if the clinical characteristics of children with gastroenteritis and influenza identified in their stool differ from those whose stool was influenza-negative. Methods: Children ...
Liu YM, Chen HC, Chen YC, et al. miR-1975 serves as an indicator of clinical severity upon influenza infection. Eur J Clin Microbiol Infect Dis. 2020;10.1007/s100. Abstract
submitted by kickingbird at Aug, 21, 2020 from Eur J Clin Microbiol Infect Dis. 2020;10.1007/s100 (via https://pubmed.ncbi.nlm.nih.gov/32814996/)
Emerging evidence highlights the role of non-coding small RNAs in host-influenza interaction. We have identified a Y RNA-derived small RNA, miR-1975, which is upregulated upon influenza A virus infection ...
Shubina M, Tummers B, Boyd DF, et al. Necroptosis restricts influenza A virus as a stand-alone cell death mechanism. J Exp Med. 2020;217(11):e20191259. Abstract
submitted by kickingbird at Aug, 18, 2020 from J Exp Med. 2020;217(11):e20191259 (via https://pubmed.ncbi.nlm.nih.gov/32797196/)
Influenza A virus (IAV) activates ZBP1-initiated RIPK3-dependent parallel pathways of necroptosis and apoptosis in infected cells. Although mice deficient in both pathways fail to control IAV and succumb ...
Patel MC, Mishin VP, De La Cruz JA, et al. Detection of baloxavir resistant influenza A viruses using next generation sequencing and pyrosequencing methods. Antiviral Res. 2020;104906. Abstract
submitted by kickingbird at Aug, 18, 2020 from Antiviral Res. 2020;104906 (via https://pubmed.ncbi.nlm.nih.gov/32798601/)
Baloxavir, a new antiviral drug targeting cap-dependent endonuclease activity of polymerase acidic (PA) protein of influenza viruses, is now approved in multiple countries. Several substitutions at isoleucine ...
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