An Y, Parsons LM, Jankowska E, Melnyk D, et al. N-Glycosylation of Seasonal Influenza Vaccine Hemagglutinins: Implication for potency testing and immune processing. J Virol. 2018 Oct 24.. Abstract
submitted by kickingbird at Oct, 27, 2018 from J Virol. 2018 Oct 24. (via https://www.ncbi.nlm.nih.gov/pubmed/30355697)
Prior to each annual flu season, health authorities recommend three or four virus strains for inclusion in the annual influenza vaccine: a Type A:H1N1, a Type A:H3N2, and one or two Type B viruses. Antigenic ...
Dornfeld D, et al. Eurasian avian-like swine influenza A viruses escape human MxA restriction by distinct mutations in their nucleoprotein. J Virol. 2018 Oct 24.. Abstract
submitted by kickingbird at Oct, 27, 2018 from J Virol. 2018 Oct 24. (via https://www.ncbi.nlm.nih.gov/pubmed/30355693)
To cross the human species barrier, influenza A viruses (IAV) of avian origin have to overcome the interferon-induced host restriction factor MxA by acquiring distinct mutations in their nucleoprotein ...
Gaba A, Xu F, Lu Y, Park HS, Liu G, Zhou Y. THE NS1 PROTEIN OF INFLUENZA A VIRUS PARTICIPATES IN NECROPTOSIS BY INTERACTING WITH MLKL AND INCREASING ITS OLIGOMERIZATION AND MEMBRANE TRANSLOCATION. J Virol. 2018 Oct 24. Abstract
submitted by kickingbird at Oct, 27, 2018 from J Virol. 2018 Oct 24 (via https://jvi.asm.org/content/early/2018/10/19/JVI.01835-18.lo)
Elimination of infected cells by programmed cell death is a well-recognized host defense mechanism to control the spread of infection. In addition to apoptosis, necroptosis is also one of the mechanisms ...
Santos JJS, et al. Plasticity of amino acid residue 145 near the receptor binding site of H3 swine influenza A viruses and its impact on receptor binding and antibody recognition. J Virol. 2018 Oct 24. Abstract
submitted by kickingbird at Oct, 27, 2018 from J Virol. 2018 Oct 24 (via https://www.ncbi.nlm.nih.gov/pubmed/30355680)
The hemagglutinin (HA), a glycoprotein on the surface of influenza A virus (IAV), initiates the virus life cycle by binding to terminal sialic acid (SA) residues on host cells. The HA gradually accumulates ...
Hird SM, Ganz H, Eisen JA, Boyce WM. The Cloacal Microbiome of Five Wild Duck Species Varies by Species and Influenza A Virus Infection Status. mSphere. 2018 Oct 24;3(5).. Abstract
submitted by kickingbird at Oct, 27, 2018 from mSphere. 2018 Oct 24;3(5). (via https://www.ncbi.nlm.nih.gov/pubmed/30355662)
Waterfowl, especially ducks of the genus Anas, are natural reservoir species for influenza A virus (IAV). Duck populations contain nearly all the known diversity of IAVs, and the birds are asymptomatic ...
Wu H, Yang F, Liu F, Lu R, Peng X, Chen B, Yao H. Isolation and characterization of novel reassortant H6N1 avian influenza viruses from chickens in Eastern China. Virol J. 2018 Oct 24;15(1):164.. Abstract
submitted by kickingbird at Oct, 27, 2018 from Virol J. 2018 Oct 24;15(1):164. (via https://www.ncbi.nlm.nih.gov/pubmed/30355336)
BACKGROUND: The H6N1 subtype of avian influenza viruses (AIVs) can infect people with an influenza-like illness; the H6N1 viruses possess the ability for zoonotic transmission from avians into mammals, ...
Wei D, et al. Genome-wide characterization of the seasonal H3N2 virus in Shanghai reveals natural temperature-sensitive strains conferred by the I668V mutation in the PA subunit. Emerg Microbes Infect. 2018 Oct 23;7(1):171. Abstract
submitted by kickingbird at Oct, 27, 2018 from Emerg Microbes Infect. 2018 Oct 23;7(1):171 (via https://www.ncbi.nlm.nih.gov/pubmed/30353004)
Seasonal H3N2 influenza viruses are recognized as major epidemic viruses, exhibiting complex seasonal patterns in regions with temperate climates. To investigate the influence of viral evolution and mutations ...
Bedi S, Noda T, Kawaoka Y, Ono A. A Defect in Influenza A Virus Particle Assembly Specific to Primary Human Macrophages. MBio. 2018 Oct 23;9(5). Abstract
submitted by kickingbird at Oct, 27, 2018 from MBio. 2018 Oct 23;9(5) (via https://www.ncbi.nlm.nih.gov/pubmed/30352935)
Influenza A virus (IAV) propagates efficiently in epithelial cells, its primary target in the respiratory tract. In contrast, productive infection of most IAV strains is either blocked or highly inefficient ...
Goldhill DH, et al. The mechanism of resistance to favipiravir in influenza. Proc Natl Acad Sci U S A. 2018 Oct 23.. Abstract
submitted by kickingbird at Oct, 27, 2018 from Proc Natl Acad Sci U S A. 2018 Oct 23. (via https://www.ncbi.nlm.nih.gov/pubmed/30352857)
Favipiravir is a broad-spectrum antiviral that has shown promise in treatment of influenza virus infections. While emergence of resistance has been observed for many antiinfluenza drugs, to date, clinical ...
Yanmei Hu, et al. Structure–Property Relationship Studies of Influenza A Virus AM2-S31N Proton Channel Blockers. ACS Med. Chem. Lett.. Abstract
submitted by kickingbird at Oct, 26, 2018 from ACS Med. Chem. Lett. (via https://pubs.acs.org/doi/abs/10.1021/acsmedchemlett.8b00336)
Majority of current circulating influenza A viruses carry the S31N mutation in their M2 genes, rendering AM2-S31N as a high profile antiviral drug target. With our continuous interest in developing AM2-S31N ...
Yu G, Tsan-Yuk Lam T, Zhu H, Guan Y. Two methods for mapping and visualizing associated data on phylogeny using ggtree. Mol Biol Evol. 2018 Oct 23.. Abstract
submitted by kickingbird at Oct, 24, 2018 from Mol Biol Evol. 2018 Oct 23. (via https://www.ncbi.nlm.nih.gov/pubmed/30351396)
Ggtree is a comprehensive R package for visualizing and annotating phylogenetic trees with associated data. It can also map and visualize associated external data on phylogenies with two general methods. ...
Denney L, Ho LP. The role of respiratory epithelium in host defence against influenza virus infection. Biomed J. 2018 Aug;41(4):218-233.. Abstract
submitted by kickingbird at Oct, 24, 2018 from Biomed J. 2018 Aug;41(4):218-233. (via https://www.ncbi.nlm.nih.gov/pubmed/30348265)
The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis ...
Toledo-Rueda W, et al. Antiviral resistance markers in influenza virus sequences in Mexico, 2000~2017. Infect Drug Resist. 2018 Oct 11;11:1751-1756. Abstract
submitted by kickingbird at Oct, 24, 2018 from Infect Drug Resist. 2018 Oct 11;11:1751-1756 (via https://www.ncbi.nlm.nih.gov/pubmed/30349332)
Background: Influenza causes high rates of morbidity and mortality. Genetic variability of influenza viruses generates resistance to antivirals, which are of two types, since they act on two different ...
Credille CV, et al. Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. J Med Chem. 2018 Oct 16. Abstract
submitted by kickingbird at Oct, 24, 2018 from J Med Chem. 2018 Oct 16 (via https://www.ncbi.nlm.nih.gov/pubmed/30351002)
Metalloenzymes represent an important target space for drug discovery. A limitation to the early development of metalloenzyme inhibitors has been the lack of established structure-activity relationships ...
Delgadillo-Gutiérrez K, et al. Stability of retroviral pseudotypes carrying the hemagglutinin of avian influenza viruses under various storage conditions. J Virol Methods. 2018 Oct 19.. Abstract
submitted by kickingbird at Oct, 23, 2018 from J Virol Methods. 2018 Oct 19. (via https://www.ncbi.nlm.nih.gov/pubmed/30347199)
Retroviral pseudotypes are broadly used as safe instruments to mimic the structure and surface of highly pathogenic viruses. They have been employed for the discovery of new drugs, as diagnostic tools ...
Davis RL, et al. The culture of primary duck endothelial cells for the study of avian influenza. BMC Microbiol. 2018 Oct 19;18(1):138. Abstract
submitted by kickingbird at Oct, 22, 2018 from BMC Microbiol. 2018 Oct 19;18(1):138 (via https://www.ncbi.nlm.nih.gov/pubmed/30340527)
BACKGROUND: Endothelial cells play a major role in highly pathogenic avian influenza (HPAI) virus pathogenesis in gallinaceous poultry species (e.g. chicken, turkey and quail). Upon infection of gallinaceous ...
Ye S, Cowled CJ, Yap CH, Stambas J. Deep sequencing of primary human lung epithelial cells challenged with H5N1 influenza virus reveals a proviral role for CEACAM1. Sci Rep. 2018 Oct 19;8(1):15468.. Abstract
submitted by kickingbird at Oct, 21, 2018 from Sci Rep. 2018 Oct 19;8(1):15468. (via https://www.ncbi.nlm.nih.gov/pubmed/30341336)
Current prophylactic and therapeutic strategies targeting human influenza viruses include vaccines and antivirals. Given variable rates of vaccine efficacy and antiviral resistance, alternative strategies ...
Ge Y, et al. Detection of reassortant avian influenza A (H11N9) virus in wild birds in China. Transbound Emerg Dis. 2018 Oct 19. Abstract
submitted by kickingbird at Oct, 21, 2018 from Transbound Emerg Dis. 2018 Oct 19 (via https://www.ncbi.nlm.nih.gov/pubmed/30338936)
Human infectious avian influenza virus (AIV) H7N9 emerged in China in 2013. The N9 gene of H7N9, which has the ability to cause death in humans, originated from an H11N9 influenza strain circulating in ...
Sun Y, et al. Aflatoxin B1 Promotes Influenza Replication and Increases Virus Related Lung Damage via Activation of TLR4 Signaling. Front Immunol. 2018 Oct 4;9:2297. Abstract
submitted by kickingbird at Oct, 21, 2018 from Front Immunol. 2018 Oct 4;9:2297 (via https://www.ncbi.nlm.nih.gov/pubmed/30337931)
Aflatoxin B1 (AFB1), which alters immune responses to mammals, is one of the most common mycotoxins in feeds and food. Swine influenza virus (SIV) is a major pathogen of both animals and humans. However, ...
Hughes HR, Brockmeier SL, Loving CL. Bordetella bronchiseptica Colonization Limits Efficacy, but Not Immunogenicity, of Live-Attenuated Influenza Virus Vaccine and Enhances Pathogenesis After Influenza Challenge. Front Immunol. 2018 Oct 4;9:2255. Abstract
submitted by kickingbird at Oct, 21, 2018 from Front Immunol. 2018 Oct 4;9:2255 (via https://www.ncbi.nlm.nih.gov/pubmed/30337924)
Intranasally administered live-attenuated influenza virus (LAIV) vaccines provide significant protection against heterologous influenza A virus (IAV) challenge. However, LAIV administration can modify ...
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