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Liu H, Gong YN, Shaw-Saliba K, Mehoke T, Evans J,. Differential disease severity and whole-genome sequence analysis for human influenza A/H1N1pdm virus in 2015-2016 influenza season. Virus Evol. 2021 May 18;7(1):veab044.  Abstract  
submitted by kickingbird at May, 28, 2021 from Virus Evol. 2021 May 18;7(1):veab044 (via https://academic.oup.com/ve/article/7/1/veab044/6261952)
During the 2015-16 winter, the US experienced a relatively mild influenza season compared to Taiwan, which had a higher number of total and severe cases. While H1N1pdm viruses dominated global surveillance ...

Senthilkumar D, Kulkarni DD, Venkatesh G, Gupta V,. Widespread Prevalence of Antibodies Against Swine Influenza A (pdm H1N1 09) Virus in Pigs of Eastern Uttar Pradesh, India. Curr Microbiol. 2021 May 26:1–9.  Abstract  
submitted by kickingbird at May, 28, 2021 from Curr Microbiol. 2021 May 26:1–9 (via https://link.springer.com/article/10.1007/s00284-021-02520-x)
Swine influenza virus (SIV) belongs to family Orthomyxoviridae and can cause acute respiratory infection in pigs. Several pandemic H1N1 human fatal influenza cases were reported in India. Though pigs are ...

Liu H, Plancarte M, Ball EE, Weiss CM, Gonzales-Vi. Respiratory tract explant infection dynamics of influenza A virus in California sea lions, northern elephant seals, and rhesus macaques. J Virol. 2021 May 26:JVI0040321.  Abstract  
submitted by kickingbird at May, 28, 2021 from J Virol. 2021 May 26:JVI0040321 (via https://pubmed.ncbi.nlm.nih.gov/34037419/)
o understand susceptibility of wild California sea lions and Northern elephant seals to influenza A virus (IAV), we developed an ex vivo respiratory explant model and used it to compare infection kinetics ...

Sun T, Guo Y, Zhao L, Fan M, Huang N, Tian M, Liu. Evolution of the PB1 gene of human influenza A(H3N2) viruses circulating between 1968 and 2019. Transbound Emerg Dis. 2021 May 25.  Abstract  
submitted by kickingbird at May, 26, 2021 from Transbound Emerg Dis. 2021 May 25 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14161)
One avian H3N2 influenza virus, providing its PB1 and HA segments, reassorted with one human H2N2 virus and caused a pandemic outbreak in 1968, killing over one million people. After its introduction to ...

Bai H, Zhao J, Ma C, Wei H, Li X, Fang Q, Yang P,. Impact of RNA degradation on influenza diagnosis in the surveillance system. Diagn Microbiol Infect Dis. 2021 May 21;100(4):115.  Abstract  
submitted by kickingbird at May, 26, 2021 from Diagn Microbiol Infect Dis. 2021 May 21;100(4):115 (via https://www.sciencedirect.com/science/article/abs/pii/S07328)
Background: The continuous evolution of influenza viruses is monitored by the World Health Organization Global Influenza Surveillance and Response System. Sample quality is essential for surveillance quality.Methods: ...

Huang Y, Lin Z, Wang W, Weiss C, Xie H, Forshee RA. Comparison of hemagglutination inhibition and hemagglutinin pseudovirus neutralization titers in relation to protection against influenza in a mouse model. Lett Appl Microbiol. 2021 May 24.  Abstract  
submitted by kickingbird at May, 25, 2021 from Lett Appl Microbiol. 2021 May 24 (via https://sfamjournals.onlinelibrary.wiley.com/doi/10.1111/lam)
The hemagglutination inhibition (HI) test has long been used as a standard measure of antibody response for inactivated influenza vaccines. However, the HI test has limitations, such as insensitivity when ...

Beerens N, Heutink R, Harders F, Roose M, Pritz-Ve. Incursion of Novel Highly Pathogenic Avian Influenza A(H5N8) Virus, the Netherlands, October 2020. Emerg Infect Dis. 2021;27(6):1750-1753.  Abstract  
submitted by kickingbird at May, 21, 2021 from Emerg Infect Dis. 2021;27(6):1750-1753 (via https://wwwnc.cdc.gov/eid/article/27/6/20-4464_article)
Highly pathogenic avian influenza A(H5N8) virus was detected in mute swans in the Netherlands during October 2020. The virus shares a common ancestor with clade 2.3.4.4b viruses detected in Egypt during ...

Li B, Su G, Xiao C, Zhang J, Li H, Sun N, Lao G, Y. The PB2 Co-adaptation of H10N8 Avian Influenza Virus Increases the Pathogenicity to Chickens and Mice. Transbound Emerg Dis. 2021 May 18.  Abstract  
submitted by kickingbird at May, 20, 2021 from Transbound Emerg Dis. 2021 May 18 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14157)
Avian influenza (AI) is an important zoonotic disease, which can be transmitted across species barriers to other hosts, especially humans, posing a serious threat to the poultry industry and public health. ...

Li J, Li R, Zhang Q, Peng P, Wang X, Gu M, Hu Z, J. H7N9 influenza virus-like particle based on BEVS protects chickens from lethal challenge with highly pathogenic H7N9 avian influenza virus. Vet Microbiol. 2021 May 8;258:109106.  Abstract  
submitted by kickingbird at May, 19, 2021 from Vet Microbiol. 2021 May 8;258:109106 (via https://www.sciencedirect.com/science/article/pii/S037811352)
H7N9 avian influenza virus poses a dual threat to both poultry industry and public health. Therefore, it is highly urgent to develop an effective vaccine to reduce its pandemic potential. Virus-like particles ...

Pu J, Zhou JT, Liu P, Yu F, He X, Lu L, Jiang S. Viral Entry Inhibitors Targeting Six-Helical Bundle Core Against Highly Pathogenic Enveloped Viruses with Class I Fusion Proteins. Curr Med Chem. 2021 May 10..  Abstract  
submitted by kickingbird at May, 19, 2021 from Curr Med Chem. 2021 May 10. (via https://www.eurekaselect.com/193289/article)
TypeⅠ enveloped viruses bind to cell receptors through surface glycoproteins to initiate infection or undergo receptor-mediated endocytosis. They also initiate membrane fusion in the acidic environment ...

Wang B, Li B, Huang H, Yang S, Jian D, Liu J, Yan. Sensitive antibody fluorescence immunosorbent assay (SAFIA) for rapid on-site detection on avian influenza virus H9N2 antibody. Anal Chim Acta. 2021 Jun 15;1164:338524.  Abstract  
submitted by kickingbird at May, 19, 2021 from Anal Chim Acta. 2021 Jun 15;1164:338524 (via https://www.sciencedirect.com/science/article/abs/pii/S00032)
Avian influenza virus (AIV) is a serious zoonotic disease causing severe damages to both poultry industry and human health. To rapidly detect AIV on-site with high sensitivity and accuracy, we design sensitive ...

Zhang P, Ling M, Tan C, Sun Y, Li X, Wang W, Cong. Preparation and evaluation of virus-like particle vaccine against H3N8 subtype equine influenza. Microb Pathog. 2021 May 12:104885.  Abstract  
submitted by kickingbird at May, 17, 2021 from Microb Pathog. 2021 May 12:104885 (via https://www.sciencedirect.com/science/article/pii/S088240102)
To prevent and control H3N8 subtype equine influenza, we prepared virus-like particles (VLPs) comprising the HA, NA and M1 proteins of H3N8 equine influenza virus (EIV) through the insect cell-baculovirus ...

Jiang Z, Wei F, Zhang Y, Wang T, Gao W, Yu S, Sun. IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection. Nat Microbiol. 2021 May 13.  Abstract  
submitted by kickingbird at May, 17, 2021 from Nat Microbiol. 2021 May 13 (via https://www.nature.com/articles/s41564-021-00907-x)
The retinoic acid-inducible gene I (RIG-I) receptor senses cytoplasmic viral RNA and activates type I interferons (IFN-I) and downstream antiviral immune responses. How RIG-I binds to viral RNA and how ...

Powell H, Liu H, Pekosz A. Changes in sialic acid binding associated with egg adaptation decrease live attenuated influenza virus replication in human nasal epithelial cell cultures. Vaccine. 2021 May 10:S0264-410X(21)00535-1.  Abstract  
submitted by kickingbird at May, 17, 2021 from Vaccine. 2021 May 10:S0264-410X(21)00535-1 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Live Attenuated Influenza Virus (LAIV) is administered to and replicates in the sinonasal epithelium. Candidate LAIV vaccine strains are selected based on their ability to replicate to a high titer in ...

Flórido M, Chiu J, Hogg PJ. Influenza A virus hemagglutinin is produced in different disulfide-bonded states. Antioxid Redox Signal. 2021 May 13.  Abstract  
submitted by kickingbird at May, 17, 2021 from Antioxid Redox Signal. 2021 May 13 (via https://www.liebertpub.com/doi/10.1089/ars.2021.0033)
Aims: Influenza A virus hemagglutinin (HA) binding to sialic acid on lung epithelial cells triggers membrane fusion and infection. Host thiol isomerases have been shown to play a role in Influenza A virus ...

Li Y, Ma Y, An Z, Yue C, Wang Y, Liu Y, Yuan X, Zh. Immunogenicity of trivalent seasonal influenza vaccine in patients with chronic obstructive pulmonary disease. Hum Vaccin Immunother. 2021 May 13:1-6.  Abstract  
submitted by kickingbird at May, 17, 2021 from Hum Vaccin Immunother. 2021 May 13:1-6 (via https://www.tandfonline.com/doi/abs/10.1080/21645515.2021.19)
Objective: Current evidence on the immunogenicity of influenza vaccination in patients with chronic obstructive pulmonary disease (COPD) is limited. To address this need for additional knowledge, we conducted ...

Okda FA, Perry SS, Webby RJ, Russell CJ. Interplay between H1N1 influenza a virus infection, extracellular and intracellular respiratory tract pH, and host responses in a mouse model. PLoS One. 2021 May 12;16(5):e0251473.  Abstract  
submitted by kickingbird at May, 14, 2021 from PLoS One. 2021 May 12;16(5):e0251473 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
During influenza A virus (IAV) entry, the hemagglutinin (HA) protein is triggered by endosomal low pH to undergo irreversible structural changes that mediate membrane fusion. HA proteins from different ...

Hara H, Chida J, Uchiyama K, Pasiana AD, Takahashi. Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells. Sci Rep. 2021 May 12;11(1):10109.  Abstract  
submitted by kickingbird at May, 14, 2021 from Sci Rep. 2021 May 12;11(1):10109 (via https://www.nature.com/articles/s41598-021-89586-6)
Misfolding of the cellular prion protein, PrPC, into the amyloidogenic isoform, PrPSc, which forms infectious protein aggregates, the so-called prions, is a key pathogenic event in prion diseases. No pathogens ...

Okda FA, Perry SS, Webby RJ, Russell CJ. Interplay between H1N1 influenza a virus infection, extracellular and intracellular respiratory tract pH, and host responses in a mouse model. PLoS One. 2021 May 12;16(5):e0251473.  Abstract  
submitted by kickingbird at May, 13, 2021 from PLoS One. 2021 May 12;16(5):e0251473 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
During influenza A virus (IAV) entry, the hemagglutinin (HA) protein is triggered by endosomal low pH to undergo irreversible structural changes that mediate membrane fusion. HA proteins from different ...

Overeem NJ, Hamming PHE, Tieke M, van der Vries E,. Multivalent Affinity Profiling: Direct Visualization of the Superselective Binding of Influenza Viruses. ACS Nano. 2021 May 12.  Abstract  
submitted by kickingbird at May, 13, 2021 from ACS Nano. 2021 May 12 (via https://pubs.acs.org/doi/10.1021/acsnano.1c00166)
The influenza A virus (IAV) interacts with the glycocalyx of host cells through its surface proteins hemagglutinin (HA) and neuraminidase (NA). Quantitative biophysical measurements of these interactions ...

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