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2019-3-22 19:28:48
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Jin M, Jang Y, Seo T, Seo SH. Inactivated H5 Antigens of H5N8 Protect Chickens from Lethal Infections by the Highly Pathogenic H5N8 and H5N6 Avian Influenza Viruses. J Vet Res. 2018 Dec 31;62(4):413-420.  Abstract  
submitted by kickingbird at Feb, 11, 2019 from J Vet Res. 2018 Dec 31;62(4):413-420 (via https://www.ncbi.nlm.nih.gov/pubmed/30729196)
Introduction: Highly pathogenic Asian H5-subtype avian influenza viruses have been found in poultry and wild birds worldwide since they were first detected in southern China in 1996. Extensive control ...

Fallah Mehrabadi MH, et al. Full-genome characterization and genetic analysis of a H9N2 virus in commercial broilers in Iran, 2017. Trop Anim Health Prod. 2019 Feb 7.  Abstract  
submitted by kickingbird at Feb, 11, 2019 from Trop Anim Health Prod. 2019 Feb 7 (via https://www.ncbi.nlm.nih.gov/pubmed/30729386)
Since 1998, Iran's poultry industry has faced several outbreaks of low pathogenic avian influenza H9N2. Tissue samples were collected from a broiler flock with respiratory symptoms in autumn 2017. After ...

Nelson MI, Souza C, et al. Human-Origin Influenza A(H3N2) Reassortant Viruses in Swine, Southeast Mexico. Emerg Infect Dis. 2019 Apr 17;25(4)..  Abstract  
submitted by kickingbird at Feb, 11, 2019 from Emerg Infect Dis. 2019 Apr 17;25(4). (via https://www.ncbi.nlm.nih.gov/pubmed/30730827)
The genetic diversity of influenza A viruses circulating in swine in Mexico complicates control efforts in animals and presents a threat to humans, as shown by influenza A(H1N1)pdm09 virus. To describe ...

Zhu H, et al. Absence of adaptive evolution is the main barrier against influenza emergence in horses in Asia despite frequent virus interspecies transmission from wild birds. PLoS Pathog. 2019 Feb 7;15(2):e1007531..  Abstract  
submitted by kickingbird at Feb, 11, 2019 from PLoS Pathog. 2019 Feb 7;15(2):e1007531. (via https://www.ncbi.nlm.nih.gov/pubmed/30731004)
Virus ecology and evolution play a central role in disease emergence. However, their relative roles will vary depending on the viruses and ecosystems involved. We combined field studies, phylogenetics ...

Nagy A, Ji?inec T, Ji?incová H, ?erníková L, et al. In silico re-assessment of a diagnostic RT-qPCR assay for universal detection of Influenza A viruses. Sci Rep. 2019 Feb 7;9(1):1630..  Abstract  
submitted by kickingbird at Feb, 11, 2019 from Sci Rep. 2019 Feb 7;9(1):1630. (via https://www.ncbi.nlm.nih.gov/pubmed/30733500)
The ongoing evolution of microbial pathogens represents a significant issue in diagnostic PCR/qPCR. Many assays are burdened with false negativity due to mispriming and/or probe-binding failures. Therefore, ...

Feng H, Yamashita M, da Silva Lopes TJ, et al. Injectable Excipients as Novel Influenza Vaccine Adjuvants. Front Microbiol. 2019 Jan 24;10:19.  Abstract  
submitted by kickingbird at Feb, 11, 2019 from Front Microbiol. 2019 Jan 24;10:19 (via https://www.ncbi.nlm.nih.gov/pubmed/30733711)
Influenza outbreaks can be either seasonal or pandemic. Vaccination is an effective strategy to control influenza; however, the efficacy of the currently available inactivated influenza virus vaccines ...

Mosaad Z, et al. In silico thermodynamic stability of mammalian adaptation and virulence determinants in polymerase complex proteins of H9N2 virus. J Genet Eng Biotechnol. 2018 Dec;16(2):757-767.  Abstract  
submitted by kickingbird at Feb, 11, 2019 from J Genet Eng Biotechnol. 2018 Dec;16(2):757-767 (via https://www.ncbi.nlm.nih.gov/pubmed/30733797)
The polymerase complex proteins (PB2, PB1, and PA) are responsible primarily for the replication of avian influenza virus and play an important role in virus virulence, mammalian adaptation, and interspecies ...

Chamberlain N, et al. Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics. Redox Biol. 2019 Jan 29;22:101129.  Abstract  
submitted by kickingbird at Feb, 11, 2019 from Redox Biol. 2019 Jan 29;22:101129 (via https://www.ncbi.nlm.nih.gov/pubmed/30735910)
Protein disulfide isomerases (PDI) are a family of redox chaperones that catalyze formation or isomerization of disulfide bonds in proteins. Previous studies have shown that one member, PDIA3, interacts ...

Wang P, et al. Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1. J Biol Chem. 2019 Feb 8..  Abstract  
submitted by kickingbird at Feb, 11, 2019 from J Biol Chem. 2019 Feb 8. (via https://www.ncbi.nlm.nih.gov/pubmed/30737282)
Most neutralizing antibodies against highly pathogenic avian influenza A virus H5N1 recognize the receptor-binding site (RBS) on the globular head domain and the stem of H5N1 hemagglutinin (HA). Through ...

Moriyama M, Ichinohe T. High ambient temperature dampens adaptive immune responses to influenza A virus infection. Proc Natl Acad Sci U S A. 2019 Feb 4..  Abstract  
submitted by kickingbird at Feb, 8, 2019 from Proc Natl Acad Sci U S A. 2019 Feb 4. (via https://www.ncbi.nlm.nih.gov/pubmed/30718396)
Although climate change may expand the geographical distribution of several vector-borne diseases, the effects of environmental temperature in host defense to viral infection in vivo are unknown. Here, ...

Sato M, et al. Generation of bat-derived influenza viruses and their reassortants. Sci Rep. 2019 Feb 4;9(1):1158..  Abstract  
submitted by kickingbird at Feb, 8, 2019 from Sci Rep. 2019 Feb 4;9(1):1158. (via https://www.ncbi.nlm.nih.gov/pubmed/30718752)
Two novel influenza A virus-like genomes were detected in fruit bats in Central and South America. However, the biological properties of these bat-derived influenza viruses (BatIVs) are still largely unknown ...

Zhao Z, et al. A Novel Reassortant Avian H7N6 Influenza Virus Is Transmissible in Guinea Pigs via Respiratory Droplets. Front Microbiol. 2019 Jan 22.  Abstract  
submitted by kickingbird at Feb, 8, 2019 from Front Microbiol. 2019 Jan 22 (via https://www.ncbi.nlm.nih.gov/pubmed/30723462)
Since 2013, H7N9 and H5N6 avian influenza viruses (AIVs) have caused sporadic human infections and deaths and continued to circulate in the poultry industry. Since 2014, H7N6 viruses which might be reassortants ...

Rajao DS, Vincent AL, Perez DR. Adaptation of Human Influenza Viruses to Swine. Front Vet Sci. 2019 Jan 22;5:347.  Abstract  
submitted by kickingbird at Feb, 8, 2019 from Front Vet Sci. 2019 Jan 22;5:347 (via https://www.ncbi.nlm.nih.gov/pubmed/30723723)
A large diversity of influenza A viruses (IAV) within the H1N1/N2 and H3N2 subtypes circulates in pigs globally, with different lineages predominating in specific regions of the globe. A common characteristic ...

Turner HL, et al. Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains. PLoS Biol. 2019 Feb 4;17(2):e3000139..  Abstract  
submitted by kickingbird at Feb, 5, 2019 from PLoS Biol. 2019 Feb 4;17(2):e3000139. (via https://www.ncbi.nlm.nih.gov/pubmed/30716060)
Seasonal influenza virus infections can cause significant morbidity and mortality, but the threat from the emergence of a new pandemic influenza strain might have potentially even more devastating consequences. ...

Prost K, et al. Bioaerosol and surface sampling for the surveillance of influenza A virus in swine. Transbound Emerg Dis. 2019 Feb 4..  Abstract  
submitted by kickingbird at Feb, 5, 2019 from Transbound Emerg Dis. 2019 Feb 4. (via https://www.ncbi.nlm.nih.gov/pubmed/30715792)
BACKGROUND: Influenza A virus in swine is of significant importance to human and veterinary public health. Environmental sampling techniques that prove practical would enhance surveillance for influenza ...

Streltsov VA, Schmidt PM, McKimm-Breschkin JL. Structure of an Influenza A virus N9 neuraminidase with a tetrabrachion-domain stalk. Acta Crystallogr F Struct Biol Commun. 2019 Feb 1;.  Abstract  
submitted by kickingbird at Feb, 5, 2019 from Acta Crystallogr F Struct Biol Commun. 2019 Feb 1; (via https://www.ncbi.nlm.nih.gov/pubmed/30713159)
The influenza neuraminidase (NA) is a homotetramer with head, stalk, transmembrane and cytoplasmic regions. The structure of the NA head with a stalk has never been determined. The NA head from an N9 subtype ...

Soli R, Kaabi B, Barhoumi M, Maktoof C, et al. Bayesian Phylogenetic Analysis of the Influenza-A virus genomes isolated in Tunisia, and Determination of Potential Recombination Events. Mol Phylogenet Evol. 2019 Jan 29..  Abstract  
submitted by kickingbird at Feb, 3, 2019 from Mol Phylogenet Evol. 2019 Jan 29. (via https://www.ncbi.nlm.nih.gov/pubmed/30708173)
The influenza-A virus (IAV) causes seasonal epidemics and presents a pandemic risk with the possibility of genetic re-assortment, allowing the emergence of new strains. The evolution of IAVes is done most ...

Linster M, et al. The molecular basis for antigenic drift of human A/H2N2 influenza viruses. J Virol. 2019 Jan 30..  Abstract  
submitted by kickingbird at Feb, 3, 2019 from J Virol. 2019 Jan 30. (via https://www.ncbi.nlm.nih.gov/pubmed/30700609)
Influenza A/H2N2 viruses caused a pandemic in 1957 and continued to circulate in humans until 1968. The antigenic evolution of A/H2N2 viruses over time and the amino acid substitutions responsible for ...

Yohei Yamauchi. Quantum dots crack the influenza uncoating puzzle. Proc Natl Acad Sci U S A. 2019 Jan 31.  Abstract  
submitted by kickingbird at Feb, 3, 2019 from Proc Natl Acad Sci U S A. 2019 Jan 31 (via https://www.pnas.org/content/early/2019/01/30/1822089116)
One hundred years ago, the devastating 1918–1919 Spanish influenza pandemic took the lives of 50 to 100 million people, or 3 to 5% of the world population (1). Influenza A virus (IAV) pandemics occur when ...

Christensen SR, et al. Assessing the protective potential of H1N1 influenza virus hemagglutinin head and stalk antibodies in humans. J Virol. 2019 Jan 30.  Abstract  
submitted by kickingbird at Feb, 3, 2019 from J Virol. 2019 Jan 30 (via https://www.ncbi.nlm.nih.gov/pubmed/30700610)
Seasonal influenza viruses are a major cause of human disease worldwide. Most neutralizing antibodies (Abs) elicited by influenza viruses target the head domain of the hemagglutinin (HA) protein. Anti-HA ...

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