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2021-4-20 6:04:27

Li X, Gu M, Zheng Q, Gao R, Liu X. Packaging signal of influenza A virus. Virol J. 2021 Feb 17;18(1):36.  Abstract  
submitted by kickingbird at Feb, 19, 2021 from Virol J. 2021 Feb 17;18(1):36 (via https://pubmed.ncbi.nlm.nih.gov/33596956/)
Influenza A virus (IAV) contains a genome with eight single-stranded, negative-sense RNA segments that encode 17 proteins. During its assembly, all eight separate viral RNA (vRNA) segments are incorporated ...

Yang F, Xiao Y, Liu F, Yao H, Wu N, Wu H. Isolation and characterization of two novel reassortant H5N6 avian influenza viruses from waterfowl in eastern China. Arch Virol. 2021 Feb 17.  Abstract  
submitted by kickingbird at Feb, 19, 2021 from Arch Virol. 2021 Feb 17 (via https://pubmed.ncbi.nlm.nih.gov/33598814/)
Waterfowl are considered to be the natural hosts of avian influenza virus. In 2017, two reassortant highly pathogenic H5N6 avian influenza viruses of clade, subclade II, were identified in wild ...

Le Sage V, Jones JE, Kormuth KA, Fitzsimmons WJ, N. Pre-existing heterosubtypic immunity provides a barrier to airborne transmission of influenza viruses. PLoS Pathog. 2021 Feb 18;17(2):e1009273.  Abstract  
submitted by kickingbird at Feb, 19, 2021 from PLoS Pathog. 2021 Feb 18;17(2):e1009273 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Human-to-human transmission of influenza viruses is a serious public health threat, yet the precise role of immunity from previous infections on the susceptibility to airborne infection is still unknown. ...

Kaku N, Hashiguchi K, Akamatsu N, Wakigawa F, Mats. Evaluation of a novel rapid TRC assay for the detection of influenza using nasopharyngeal swabs and gargle samples. Eur J Clin Microbiol Infect Dis. 2021 Feb 16.  Abstract  
submitted by kickingbird at Feb, 17, 2021 from Eur J Clin Microbiol Infect Dis. 2021 Feb 16 (via https://pubmed.ncbi.nlm.nih.gov/33594599/)
We evaluated a novel transcription-reverse transcription concerted reaction (TRC) assay that can detect influenza A and B within 15 min using nasopharyngeal swab and gargle samples obtained from patients ...

Li APY, Cohen CA, Leung NHL, Fang VJ, Gangappa S,. Immunogenicity of standard, high-dose, MF59-adjuvanted, and recombinant-HA seasonal influenza vaccination in older adults. NPJ Vaccines. 2021 Feb 16;6(1):25.  Abstract  
submitted by kickingbird at Feb, 17, 2021 from NPJ Vaccines. 2021 Feb 16;6(1):25 (via https://pubmed.ncbi.nlm.nih.gov/33594050/)
The vaccine efficacy of standard-dose seasonal inactivated influenza vaccines (S-IIV) can be improved by the use of vaccines with higher antigen content or adjuvants. We conducted a randomized controlled ...

Roubidoux EK, Carre?o JM, McMahon M, Jiang K, van. Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model. mBio. 2021 Feb 16;12(1):e03617-20.  Abstract  
submitted by kickingbird at Feb, 17, 2021 from mBio. 2021 Feb 16;12(1):e03617-20 (via https://mbio.asm.org/content/12/1/e03617-20)
Current seasonal influenza virus vaccines target regions of the hemagglutinin (HA) head domain that undergo constant antigenic change, forcing the painstaking annual reformulation of vaccines. The development ...

Freyn AW, Han J, Guthmiller JJ, Bailey MJ, Neu K,. Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2018.  Abstract  
submitted by kickingbird at Feb, 17, 2021 from Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2018 (via https://www.pnas.org/content/118/8/e2018102118)
In this study, we utilized a panel of human immunoglobulin (Ig) IgA monoclonal antibodies isolated from the plasmablasts of eight donors after 2014/2015 influenza virus vaccination (Fluarix) to study the ...

Wang B, Su Q, Luo J, Li M, Wu Q, Chang H, Du J, Hu. Differences in Highly Pathogenic H5N6 Avian Influenza Viral Pathogenicity and Inflammatory Response in Chickens and Ducks. Front Microbiol. 2021 Jan 29;12:593202.  Abstract  
submitted by kickingbird at Feb, 16, 2021 from Front Microbiol. 2021 Jan 29;12:593202 (via https://www.frontiersin.org/articles/10.3389/fmicb.2021.5932)
Infection with H5N6 highly pathogenic avian influenza virus caused high mortality in chickens, while ducks often appear to be asymptomatic. But, some recent H5Nx subtype viruses could cause high mortality ...

Huang J, Wu S, Wu W, Liang Y, Zhuang H, Ye Z, Qu X. The Biological Characteristics of Novel H5N6 Highly Pathogenic Avian Influenza Virus and Its Pathogenesis in Ducks. Front Microbiol. 2021 Jan 26;12:628545.  Abstract  
submitted by kickingbird at Feb, 16, 2021 from Front Microbiol. 2021 Jan 26;12:628545 (via https://www.frontiersin.org/articles/10.3389/fmicb.2021.6285)
Clade H5Nx highly pathogenic avian influenza viruses (HPAIVs) have caused outbreaks in poultry in the world. Some of these viruses acquired internal genes from other subtype avian influenza viruses ...

Gierak A, ?mietanka K, de Vos CJ. Quantitative risk assessment of the introduction of low pathogenic avian influenza H5 and H7 strains into Poland via legal import of live poultry. Prev Vet Med. 2021 Jan 28;189:105289.  Abstract  
submitted by kickingbird at Feb, 16, 2021 from Prev Vet Med. 2021 Jan 28;189:105289 (via https://www.sciencedirect.com/science/article/abs/pii/S01675)
Low pathogenic avian influenza (LPAI) caused by H5 and H7 viruses is considered a threatening disease for poultry production due to the possibility of prolonged undetected virus circulation in a poultry ...

Hulme KD, Karawita AC, Pegg C, Bunte MJ, Bielefeld. A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants. Elife. 2021 Feb 16;10:e61803.  Abstract  
submitted by kickingbird at Feb, 16, 2021 from Elife. 2021 Feb 16;10:e61803 (via https://pubmed.ncbi.nlm.nih.gov/33588989/)
Influenza virus has a high mutation rate, such that within one host different viral variants can emerge. Evidence suggests that influenza virus variants are more prevalent in pregnant and/or obese individuals ...

Tsuneki-Tokunaga A, Kanai K, Itagaki A, Tsuchie H,. Growth capability of epidemic influenza viruses in Japan since the 2009 H1N1 pandemic. Arch Virol. 2021 Feb 12.  Abstract  
submitted by kickingbird at Feb, 14, 2021 from Arch Virol. 2021 Feb 12 (via https://link.springer.com/article/10.1007/s00705-021-04976-5)
AbstractThe correlation of viral growth capability (n = 156) with the viral load in nasopharyngeal swabs (n = 76) was assessed. Epidemic influenza A/H1N1, A/H3N2, and B viruses showed a wide range of growth ...

Hidekazu Osada, Chon I, Phyu WW, Wagatsuma K, Naga. Development of cycling probe based real-time PCR methodology for influenza A viruses possessing the PA/I38T amino acid substitution associated with reduced baloxavir susceptibility. Antiviral Res. 2021 Feb 9:105036.  Abstract  
submitted by kickingbird at Feb, 14, 2021 from Antiviral Res. 2021 Feb 9:105036 (via https://www.sciencedirect.com/science/article/abs/pii/S01663)
Baloxavir marboxil has been used for influenza treatment since March 2018 in Japan. After baloxavir treatment, the most frequently detected substitution is Ile38Thr in polymerase acidic protein (PA/I38T), ...

Ashraf U, Benoit-Pilven C, Navratil V, Ligneau C,. Influenza virus infection induces widespread alterations of host cell splicing. NAR Genom Bioinform. 2020 Nov 21;2(4):lqaa095.  Abstract  
submitted by kickingbird at Feb, 13, 2021 from NAR Genom Bioinform. 2020 Nov 21;2(4):lqaa095 (via https://academic.oup.com/nargab/article/2/4/lqaa095/5998301)
Influenza A viruses (IAVs) use diverse mechanisms to interfere with cellular gene expression. Although many RNA-seq studies have documented IAV-induced changes in host mRNA abundance, few were designed ...

Zeng Y, Xu S, Wei Y, Zhang X, Wang Q, Jia Y, Wang. The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation. PLoS Pathog. 2021 Feb 12;17(2):e1009300.  Abstract  
submitted by kickingbird at Feb, 13, 2021 from PLoS Pathog. 2021 Feb 12;17(2):e1009300 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A virus (IAV) has evolved various strategies to counteract the innate immune response using different viral proteins. However, the mechanism is not fully elucidated. In this study, we identified ...

Almatrrouk S, Saba I, Abozaid S, Al-Qahtani AA, Al. Virus sensing receptors in cellular infectivity of influenza A virus. J Infect Dev Ctries. 2021 Jan 31;15(1):1-8.  Abstract  
submitted by kickingbird at Feb, 12, 2021 from J Infect Dev Ctries. 2021 Jan 31;15(1):1-8 (via https://www.jidc.org/index.php/journal/article/view/13258)
An innate immune response is essential to mobilize protective immunity upon the infection of respiratory epithelial cells with influenza A virus (IAV). The response is classified as early (nonspecific ...

Lopez Moreno G, Nirmala J, Goodell C, Culhane M, T. Shedding and transmission of a live attenuated influenza A virus vaccine in pre-weaned pigs under field conditions. PLoS One. 2021 Feb 11;16(2):e0246690.  Abstract  
submitted by kickingbird at Feb, 12, 2021 from PLoS One. 2021 Feb 11;16(2):e0246690 (via https://pubmed.ncbi.nlm.nih.gov/33571263/)
Influenza A virus (IAV) is one of the most important respiratory viruses affecting pig health and vaccination is the most common strategy to control influenza infections. In this field study we assessed ...

Li J, Liang L, Jiang L, Wang Q, Wen X, Zhao Y, Cui. Viral RNA-binding ability conferred by SUMOylation at PB1 K612 of influenza A virus is essential for viral pathogenesis and transmission. PLoS Pathog. 2021 Feb 11;17(2):e1009336.  Abstract  
submitted by kickingbird at Feb, 12, 2021 from PLoS Pathog. 2021 Feb 11;17(2):e1009336 (via https://pubmed.ncbi.nlm.nih.gov/33571308/)
Posttranslational modifications, such as SUMOylation, play specific roles in the life cycle of invading pathogens. However, the effect of SUMOylation on the adaptation, pathogenesis, and transmission of ...

Venkatramanan S, Sadilek A, Fadikar A, Barrett CL,. Forecasting influenza activity using machine-learned mobility map. Nat Commun. 2021 Feb 9;12(1):726.  Abstract  
submitted by kickingbird at Feb, 11, 2021 from Nat Commun. 2021 Feb 9;12(1):726 (via https://www.nature.com/articles/s41467-021-21018-5)
Human mobility is a primary driver of infectious disease spread. However, existing data is limited in availability, coverage, granularity, and timeliness. Data-driven forecasts of disease dynamics are ...

Kong H, Burke DF, da Silva Lopes TJ, Takada K, Ima. Plasticity of the Influenza Virus H5 HA Protein. mBio. 2021 Feb 9;12(1):e03324-20.  Abstract  
submitted by kickingbird at Feb, 11, 2021 from mBio. 2021 Feb 9;12(1):e03324-20 (via https://mbio.asm.org/content/12/1/e03324-20)
Since the emergence of highly pathogenic avian influenza viruses of the H5 subtype, the major viral antigen, hemagglutinin (HA), has undergone constant evolution, resulting in numerous genetic and antigenic ...

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