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2019-5-22 10:02:19
Article

Wang P, et al. The PB2 Polymerase Host Adaptation Substitutions Prime Avian Indonesia Sub Clade 2.1 H5N1 Viruses for Infecting Humans. Viruses. 2019 Mar 22;11(3)..  Abstract  
submitted by kickingbird at Mar, 27, 2019 from Viruses. 2019 Mar 22;11(3). (via https://www.mdpi.com/1999-4915/11/3/292)
Significantly higher numbers of human infections with H5N1 virus have occurred in Indonesia and Egypt, compared with other affected areas, and it is speculated that there are specific viral factors for ...

Li X, et al. Rapid Evolution and Gene Communication of H3N2 and H1N1 Influenza A Viruses. J Infect. 2019 Mar 22. pii: S0163-4453(19)30094-5..  Abstract  
submitted by kickingbird at Mar, 27, 2019 from J Infect. 2019 Mar 22. pii: S0163-4453(19)30094-5. (via https://www.journalofinfection.com/article/S0163-4453(19)300)
?The haplotype network map shows that the 2014 H1N1 strain has gene communication with the 2016/17 H3N2 strain,it may change in the characteristic of the virus by gene communication.?The genetic evolution ...

Kode SS, et al. Selection of avian influenza A (H9N2) virus with reduced susceptibility to neuraminidase inhibitors oseltamivir and zanamivir. Virus Res. 2019 Mar 22..  Abstract  
submitted by kickingbird at Mar, 27, 2019 from Virus Res. 2019 Mar 22. (via https://www.sciencedirect.com/science/article/abs/pii/S01681)
Identification of amino-acid substitutions in the neuraminidase (NA) of low-pathogenic avian influenza (AI) H9N2 viruses is important to study the susceptibility to NA inhibitors (NAI). To identify mutations ...

Rane CK, et al. Development of solitary chemosensory cells in the distal lung after severe influenza injury. Am J Physiol Lung Cell Mol Physiol. 2019 Mar 25..  Abstract  
submitted by kickingbird at Mar, 26, 2019 from Am J Physiol Lung Cell Mol Physiol. 2019 Mar 25. (via https://www.physiology.org/doi/abs/10.1152/ajplung.00032.201)
H1N1 influenza virus infection induces dramatic and permanent alveolar remodeling mediated by p63+ progenitor cell expansion in both mice and some patients with acute respiratory distress syndrome. This ...

Magnen M, et al. Tissue kallikrein (KLK1) regulates alveolar macrophage apoptosis early in influenza virus infection. Am J Physiol Lung Cell Mol Physiol. 2019 Mar 25..  Abstract  
submitted by kickingbird at Mar, 26, 2019 from Am J Physiol Lung Cell Mol Physiol. 2019 Mar 25. (via https://www.physiology.org/doi/abs/10.1152/ajplung.00379.201)
Host cell proteases are involved in influenza pathogenesis. We examined the role of tissue kallikrein 1 (KLK1) by comparing wild-type (WT) and KLK1-deficient mice infected with influenza H3N2 virus. Levels ...

She YM, Li X, Cyr TD. Remarkable Structural Diversity of N-Glycan Sulfation on Influenza Vaccines. Anal Chem. 2019 Mar 25..  Abstract  
submitted by kickingbird at Mar, 26, 2019 from Anal Chem. 2019 Mar 25. (via https://pubs.acs.org.ccindex.cn/doi/10.1021/acs.analchem.8b0)
Sulfated N-glycans are biologically important structures derived from enzymatically post-glycosylational modifications of glycoproteins in many therapeutic biologics. The high-throughput analysis of sulfated ...

H?fer CT, et al. Structural determinants of the interaction between influenza a virus matrix protein M1 and lipid membranes. Biochim Biophys Acta Biomembr. 2019 Mar 19.  Abstract  
submitted by kickingbird at Mar, 26, 2019 from Biochim Biophys Acta Biomembr. 2019 Mar 19 (via https://www.sciencedirect.com/science/article/pii/S000527361)
Influenza A virus is a pathogen responsible for severe seasonal epidemics threatening human and animal populations every year. One of the ten proteins encoded by the viral genome, the matrix protein M1, ...

Stepanova EA, et al. Amino Acid Substitutions N123D and N149D in Hemagglutinin Molecule Enhance Immunigenicity of Live Attenuated Influenza H7N9 Vaccine Strain in Experiment. Bull Exp Biol Med. 2019 Mar 22..  Abstract  
submitted by kickingbird at Mar, 26, 2019 from Bull Exp Biol Med. 2019 Mar 22. (via https://link.springer.com/article/10.1007%2Fs10517-019-04407)
We compared three cold-adapted live attenuated influenza vaccine strains prepared by reverse genetics methods on the basis of master donor virus A/Leningrad/134/17/57 and influenza H7N9 strains A/Anhui/1/2013 ...

Fujioka Y, et al. A peptide derived from phosphoinositide 3-kinase inhibits endocytosis and influenza virus infection. Cell Struct Funct. 2019 Mar 21..  Abstract  
submitted by kickingbird at Mar, 26, 2019 from Cell Struct Funct. 2019 Mar 21. (via https://www.jstage.jst.go.jp/article/csf/advpub/0/advpub_190)
Endocytosis mediates the internalization and ingestion of a variety of endogenous or exogenous substances, including virus particles, under the control of intracellular signaling pathways. We have previously ...

Kannan S, Shankar R, Kolandaivel P. Insights into structural and inhibitory mechanisms of low pH-induced conformational change of influenza HA2 protein: a computational approach. J Mol Model. 2019 Mar 23;25(4):99.  Abstract  
submitted by kickingbird at Mar, 26, 2019 from J Mol Model. 2019 Mar 23;25(4):99 (via https://link.springer.com/article/10.1007%2Fs00894-019-3982-)
Though oseltamivir and zanamivir are the active anti-influenza drugs, the emergence of different strains of influenza A virus with mutations creates drug-resistance to these drugs. Therefore, it is essential ...

Akand EH, Downard KM. Mechanisms of Antiviral Resistance in Influenza Neuraminidase Revealed by a Mass Spectrometry Based Phylonumerics Approach. Mol Phylogenet Evol. 2019 Mar 20.  Abstract  
submitted by kickingbird at Mar, 26, 2019 from Mol Phylogenet Evol. 2019 Mar 20 (via https://www.sciencedirect.com/science/article/pii/S105579031)
A mass based phylonumerics approach is shown to be able to investigate the origins of the emergence of antiviral resistance mutations in influenza neuraminidase through a global view of mutational trends. ...

Yamamoto Y, et al. Peptides with the multibasic cleavage site of the hemagglutinin from highly pathogenic influenza viruses act as cell-penetrating via binding to heparan sulfate and neuropilins. Biochem Biophys Res Commun. 2019 Mar 20.  Abstract  
submitted by kickingbird at Mar, 26, 2019 from Biochem Biophys Res Commun. 2019 Mar 20 (via https://www.sciencedirect.com/science/article/pii/S0006291X1)
Cell-penetrating peptides (CPPs) show promise as an attractive delivery vehicle for therapeutic molecules-including nucleic acids, peptides, proteins, and even particulates-into several cell types. It ...

Cherdantseva LA, et al. Death Mechanisms of Pulmonary Alveolocytes in Mice Infected with Influenza Viruses A/H1N1/California/04/2009 and A/H5N1/Goose/Krasnoozerskoye/627/05. Bull Exp Biol Med. 2019 Mar 22.  Abstract  
submitted by kickingbird at Mar, 26, 2019 from Bull Exp Biol Med. 2019 Mar 22 (via https://link.springer.com/article/10.1007%2Fs10517-019-04408)
In CBA mice infected with influenza viruses A/H1N1/California/04/2009 and A/H5N1/Goose/Krasnoozerskoye/627/05 in a dose of 10 MLD50, the mechanisms of death of pulmonary alveolocytes over 10 postinfection ...

Amarelle L, et al. Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery. Am J Physiol Lung Cell Mol Physiol. 2019 Mar 20.  Abstract  
submitted by kickingbird at Mar, 25, 2019 from Am J Physiol Lung Cell Mol Physiol. 2019 Mar 20 (via https://www.physiology.org/doi/abs/10.1152/ajplung.00173.201)
Cardiac glycosides (CG) are used primarily for cardiac failure and have been reported to have other effects, including inhibition of viral replication. Here we set out to study mechanisms by which CG as ...

Oishi K, Yamayoshi S, Kawaoka Y. Identification of Amino Acid Residues in Influenza A Virus PA-X That Contribute to Enhanced Shutoff Activity. Front Microbiol. 2019 Mar 6;10:432..  Abstract  
submitted by kickingbird at Mar, 25, 2019 from Front Microbiol. 2019 Mar 6;10:432. (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0043)
The influenza virus protein PA-X modulates the host immune responses and viral pathogenicity through suppression of host protein expression. The endonuclease active site in the N-terminal region, the basic ...

Karunarathna HMTK, et al. Serum anti-neuraminidase antibody responses in human influenza A(H1N1)pdm09 virus infections. Emerg Microbes Infect. 2019;8(1):404-412..  Abstract  
submitted by kickingbird at Mar, 24, 2019 from Emerg Microbes Infect. 2019;8(1):404-412. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Haemagglutination inhibition (HAI) antibody titres are a correlate of protection for influenza virus infection, but several studies have also demonstrated the protective role of anti-neuraminidase (anti-NA) ...

Kumar P, et al. IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection. Sci Rep. 2019 Mar 21;9(1):4984.  Abstract  
submitted by kickingbird at Mar, 24, 2019 from Sci Rep. 2019 Mar 21;9(1):4984 (via https://www.nature.com/articles/s41598-019-41478-6)
Influenza virus targets epithelial cells in the upper respiratory tract. Natural Killer (NK) cell-mediated early innate defense responses to influenza infection include the killing of infected epithelial ...

Zheng H, et al. Evolved avian influenza virus (H7N9) isolated from human cases in a middle Yangtze River city in China, from February to April 2017. Heliyon. 2019 Mar 7;5(3):e01253..  Abstract  
submitted by kickingbird at Mar, 24, 2019 from Heliyon. 2019 Mar 7;5(3):e01253. (via https://www.heliyon.com/article/e01253)
Seven cases of avian influenza A H7N9 virus infection were reported from February to April 2017 in Changsha City. Viral genome was acquired by RT-PCR, aligned with other H7N9 viruses using Clustal W, and ...

Yasuhara A, et al. Antigenic drift originating from changes to the lateral surface of the neuraminidase head of influenza A virus. Nat Microbiol. 2019 Mar 18..  Abstract  
submitted by kickingbird at Mar, 21, 2019 from Nat Microbiol. 2019 Mar 18. (via https://www.nature.com/articles/s41564-019-0401-1)
Influenza viruses possess two surface glycoproteins, haemagglutinin and neuraminidase (NA). Although haemagglutinin plays a major role as a protective antigen, immunity to NA also contributes to protection. ...

Hajam IA, Kim J, Lee JH. Intranasally administered polyethylenimine adjuvanted influenza M2 ectodomain induces partial protection against H9N2 influenza A virus infection in chickens. Vet Immunol Immunopathol. 2019 Mar;209:78-83..  Abstract  
submitted by kickingbird at Mar, 21, 2019 from Vet Immunol Immunopathol. 2019 Mar;209:78-83. (via https://www.sciencedirect.com/science/article/pii/S016524271)
This study aimed to investigate whether intranasally coadministered four tandem copies of extracellular domains of M2 (M2e) and polyethyleneimine (PEI), a mucosal adjuvant, can protect chickens against ...

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