Zhang K, et al. Structural basis for influenza virus NS1 protein block of mRNA nuclear export. Nat Microbiol. 2019 Jul 1.. Abstract
submitted by kickingbird at Jul, 7, 2019 from Nat Microbiol. 2019 Jul 1. (via https://www.nature.com/articles/s41564-019-0482-x)
Influenza viruses antagonize key immune defence mechanisms via the virulence factor non-structural protein 1 (NS1). A key mechanism of virulence by NS1 is blocking nuclear export of host messenger RNAs, ...
Watkins LC, Liang R, Swanson JMJ, DeGrado WF, Voth. Proton Induced Conformational and Hydration Dynamics in the Influenza A M2 Channel. J Am Chem Soc. 2019 Jul 2.. Abstract
submitted by kickingbird at Jul, 7, 2019 from J Am Chem Soc. 2019 Jul 2. (via https://pubs.acs.org/doi/10.1021/jacs.9b05136)
The influenza A M2 protein is an acid-activated proton channel responsible for the acidification of the inside of the virus, a critical step in the viral life cycle. This channel has four central histidine ...
Zhou L, Li Q, Uyeki TM.. Estimated Incubation Period and Serial Interval for Human-to-Human Influenza A(H7N9) Virus Transmission. Emerg Infect Dis. 2019 Oct 17;25(10).. Abstract
submitted by kickingbird at Jul, 7, 2019 from Emerg Infect Dis. 2019 Oct 17;25(10). (via https://wwwnc.cdc.gov/eid/article/25/10/19-0117_article)
We estimated the incubation period and serial interval for human-to-human-transmitted avian influenza A(H7N9) virus infection using case-patient clusters from epidemics in China during 2013-2017. The median ...
Arai Y, et al. PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammals. PLoS Pathog. 2019 Jul 2;15(7):e1007919.. Abstract
submitted by kickingbird at Jul, 7, 2019 from PLoS Pathog. 2019 Jul 2;15(7):e1007919. (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Avian influenza virus H9N2 has been endemic in birds in the Middle East, in particular in Egypt with multiple cases of human infections since 1998. Despite concerns about the pandemic threat posed by H9N2, ...
Tang J, et al. Highly pathogenic avian influenza H7N9 viruses with reduced susceptibility to neuraminidase inhibitors showed comparable replication capacity to their sensitive counterparts. Virol J. 2019 Jul 2;16(1):87. Abstract
submitted by kickingbird at Jul, 7, 2019 from Virol J. 2019 Jul 2;16(1):87 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
BACKGROUND: Human infection with avian influenza H7N9 virus was first reported in 2013. Since the fifth epidemic, a highly pathogenic avian influenza (HPAI) H7N9 virus has emerged and caused 33 human infections. ...
Zhu W, et al. Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice. Emerg Microbes Infect. 2019;8(1):989-999.. Abstract
submitted by kickingbird at Jul, 7, 2019 from Emerg Microbes Infect. 2019;8(1):989-999. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
It has recently been proposed that the Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) is one of the most likely zoonotic viruses to cause the next influenza pandemic. Two main genotypes ...
Bradley KC, et al. Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection. Cell Rep. 2019 Jul 2;28(1):245-256.e4. Abstract
submitted by kickingbird at Jul, 7, 2019 from Cell Rep. 2019 Jul 2;28(1):245-256.e4 (via https://www.cell.com/cell-reports/fulltext/S2211-1247(19)307)
Type I interferon (IFNα/β) pathways are fine-tuned to elicit antiviral protection while minimizing immunopathology; however, the initiating stimuli, target tissues, and underlying mechanisms are unclear. ...
Li X, Gao Y, Ye Z. A Single Amino Acid Substitution at Residue 218 of Hemagglutinin Improves the Growth of Influenza A(H7N9) Candidate Vaccine Viruses. J Virol. 2019 Jul 3. pii: JVI.00570-19. Abstract
submitted by kickingbird at Jul, 7, 2019 from J Virol. 2019 Jul 3. pii: JVI.00570-19 (via https://jvi.asm.org/content/early/2019/06/27/JVI.00570-19)
The potential avian influenza pandemic remains a threat to public health, as the avian-originated influenza A(H7N9) virus has caused more than 1560 laboratory-confirmed human infections since 2013, with ...
Cohen L, et al. A Modular Cytokine Analysis Method Reveals Novel Associations With Clinical Phenotypes and Identifies Sets of Co-signaling Cytokines Across Influenza Natural Infection Cohorts and Healthy Controls. Front Immunol. 2019 Jun 18. Abstract
submitted by kickingbird at Jul, 7, 2019 from Front Immunol. 2019 Jun 18 (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0133)
Cytokines and chemokines are key signaling molecules of the immune system. Recent technological advances enable measurement of multiplexed cytokine profiles in biological samples. These profiles can then ...
Boumart Z, et al. Pathogenicity and Full Genome Sequencing of the Avian Influenza H9N2 Moroccan Isolate 2016. Avian Dis. 2018 Nov 16;63(1):24-30. Abstract
submitted by kickingbird at Jul, 2, 2019 from Avian Dis. 2018 Nov 16;63(1):24-30 (via https://bioone.org/journals/Avian-Diseases/volume-63/issue-1)
In Morocco in early 2016, a low pathogenic avian influenza virus serotype H9N2 caused large economic losses to the poultry industry, with specific clinical symptoms and high mortality rates on infected ...
Guo F, et al. Adaptive Evolution of Human-Isolated H5Nx Avian Influenza A Viruses. Front Microbiol. 2019 Jun 12;10:1328. Abstract
submitted by kickingbird at Jul, 2, 2019 from Front Microbiol. 2019 Jun 12;10:1328 (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0132)
Avian influenza A viruses (AIVs) H5N1, first identified in 1996, are highly pathogenic in domestic poultry and continue to occasionally infect humans. In this study, we sought to identify genetic changes ...
Spackman E, et al. Clade 188.8.131.52 H5 North American Highly Pathogenic Avian Influenza Viruses Infect, but Do Not Cause Clinical Signs in, American Black Ducks (Anas rubripes).. Avian Dis. 2019 Jan 18;63(2):366-370. Abstract
submitted by kickingbird at Jul, 2, 2019 from Avian Dis. 2019 Jan 18;63(2):366-370 (via https://www.ncbi.nlm.nih.gov/pubmed/31251539)
Highly pathogenic avian influenza virus (HPAIV) from the goose/Guangdong/1996 clade 184.108.40.206 H5 lineage spread from Asia into North America in 2014, most likely by wild bird migrations. Although several ...
Mine J, et al. Phylogeographic evidence for the inter-and intracontinental dissemination of avian influenza viruses via migration flyways. PLoS One. 2019 Jun 26;14(6):e0218506.. Abstract
submitted by kickingbird at Jun, 28, 2019 from PLoS One. 2019 Jun 26;14(6):e0218506. (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Genetically related highly pathogenic avian influenza viruses (HPAIVs) of H5N6 subtype caused outbreaks simultaneously in East Asia and Europe-geographically distinct regions-during winter 2017-2018. This ...
Zhuang Q, et al. Diversity and distribution of type A influenza viruses: an updated panorama analysis based on protein sequences. Virol J. 2019 Jun 26;16(1):85. Abstract
submitted by kickingbird at Jun, 28, 2019 from Virol J. 2019 Jun 26;16(1):85 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
BACKGROUND: Type A influenza viruses (IAVs) cause significant infections in humans and multiple species of animals including pigs, horses, birds, dogs and some marine animals. They are of complicated phylogenetic ...
Leach S, et al. Requirement for memory B cell activation in protection from heterologous influenza virus reinfection. Int Immunol. 2019 Jun 20.. Abstract
submitted by kickingbird at Jun, 25, 2019 from Int Immunol. 2019 Jun 20. (via https://academic.oup.com/intimm/advance-article-abstract/doi)
While two memory compartments, memory B cells and long-lived plasma cells, are thought to contribute to the successful establishment of memory recall responses, the unique roles of each cellular compartment ...
Yan HX, Xu HF, He WJ, Xie Y, Dong GY.. Phylogenetic analysis of HA and NA genes of influenza H1N1 viruses from 1918 to 2017. Acta Virol. 2019;63(2):195-202.. Abstract
submitted by kickingbird at Jun, 25, 2019 from Acta Virol. 2019;63(2):195-202. (via https://www.ncbi.nlm.nih.gov/pubmed/31230448)
The 1918 "Spanish" pandemic is the earliest known influenza H1N1 virus. Since then H1N1 viruses circulated between humans and animals continuously. With the increased amount of samples of H1N1 viruses ...
Ma MJ, et al. Characterization of antibody and memory T cell response in H7N9 survivors: A cross-sectional analysis. Clin Microbiol Infect. 2019 Jun 20. Abstract
submitted by kickingbird at Jun, 25, 2019 from Clin Microbiol Infect. 2019 Jun 20 (via https://www.clinicalmicrobiologyandinfection.com/article/S11)
OBJECTIVES: Despite the importance of immunological memory for protective immunity against viral infection, whether H7N9-specific antibodies and memory T-cell responses remain detectable years after the ...
Adams SE, et al. Effect of influenza H1N1 neuraminidase V116A and I117V mutations on NA activity and sensitivity to NA inhibitors. Antiviral Res. 2019 Jun 19:104539.. Abstract
submitted by kickingbird at Jun, 24, 2019 from Antiviral Res. 2019 Jun 19:104539. (via https://www.sciencedirect.com/science/article/pii/S016635421)
Neuraminidase inhibitors (NAIs) play a key role in the management of influenza. Given the limited number of FDA-approved anti-influenza drugs, evaluation of potential drug-resistant variants is of high ...
Nemoto M, et al. A single amino acid change in hemagglutinin reduces the cross-reactivity of antiserum against an equine influenza vaccine strain. Arch Virol. 2019 Jun 21.. Abstract
submitted by kickingbird at Jun, 24, 2019 from Arch Virol. 2019 Jun 21. (via https://link.springer.com/article/10.1007%2Fs00705-019-04328)
Equine influenza virus is an important pathogen for the horse industry because of its economic impact, and vaccination is a key control measure. Our previous work suggested that a mutation at position ...
Prier JE, et al. Early T-BET Expression Ensures an Appropriate CD8+ Lineage-Specific Transcriptional Landscape after Influenza A Virus Infection. J Immunol. 2019 Jun 21.. Abstract
submitted by kickingbird at Jun, 24, 2019 from J Immunol. 2019 Jun 21. (via https://www.jimmunol.org/content/early/2019/06/21/jimmunol.1)
Virus infection triggers large-scale changes in the phenotype and function of naive CD8+ T cells, resulting in the generation of effector and memory T cells that are then critical for immune clearance. ...
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