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2024-7-17 1:47:00
Article

ia M, Zhao H, Morano NC, Lu H, Lui YM, Du H, Becke. Human neutralizing antibodies target a conserved lateral patch on H7N9 hemagglutinin head. Nat Commun. 2024 May 27;15(1):4505.  Abstract  
submitted by kickingbird at May, 29, 2024 from Nat Commun. 2024 May 27;15(1):4505 (via https://www.nature.com/articles/s41467-024-48758-4)
Avian influenza A virus H7N9 causes severe human infections with >30% fatality. Currently, there is no H7N9-specific prevention or treatment for humans. Here, from a 2013 H7N9 convalescent case in Hong ...

Kessler S, Burke B, Andrieux G, Schink?the J, Hamb. Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level. Nat Commun. 2024 May 27;15(1):4500.  Abstract  
submitted by kickingbird at May, 29, 2024 from Nat Commun. 2024 May 27;15(1):4500 (via https://www.nature.com/articles/s41467-024-48934-6)
Jamaican fruit bats (Artibeus jamaicensis) naturally harbor a wide range of viruses of human relevance. These infections are typically mild in bats, suggesting unique features of their immune system. To ...

Swanson NJ, Girish J, Yunker M, Liu H, Norton J, H. [preprint]Clade-defining mutations in human H1N1 hemagglutinin protein from 2021-2023 have opposing effects on in vitro fitness and antigenic drift. https://doi.org/10.1101/2024.05.18.594815.  Abstract  
submitted by kickingbird at May, 29, 2024 from https://doi.org/10.1101/2024.05.18.594815 (via https://www.biorxiv.org/content/10.1101/2024.05.18.594815v1)
Seasonal influenza viruses frequently acquire mutations that have the potential to alter both virus replication and antigenic profile. Recent seasonal H1N1 viruses have acquired mutations to their hemagglutinin ...

Teo QW, Wang Y, Lv H, Mao KJ, Tan TJC, Huan YW, Ri. [preprint]Deep mutational scanning of influenza A virus NEP reveals pleiotropic mutations in its N-terminal domain. https://doi.org/10.1101/2024.05.16.594574.  Abstract  
submitted by kickingbird at May, 29, 2024 from https://doi.org/10.1101/2024.05.16.594574 (via https://www.biorxiv.org/content/10.1101/2024.05.16.594574v1)
The influenza A virus nuclear export protein (NEP) is a multifunctional protein that is essential for the viral life cycle and has very high sequence conservation. However, since the open reading frame ...

Guiomar R, Pereira da Silva S, Costa I, Conde P, C. Seroprevalence of Protective Antibodies Against Influenza and the Reduction of the Influenza Incidence Rate: An Annual Repeated Cross-Sectional Study From 2014 to 2019. Influenza Other Respir Viruses. 2024 May;18(5):e13.  Abstract  
submitted by kickingbird at May, 29, 2024 from Influenza Other Respir Viruses. 2024 May;18(5):e13 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.13307)
Background: Seroepidemiological studies provide estimates of population-level immunity, prevalence/incidence of infections, and evaluation of vaccination programs. We assessed the seroprevalence of protective ...

Brogaard L, Heegaard PMH, Larsen LE, Skovgaard K. Pulmonary MicroRNA expression after heterologous challenge with swine influenza A virus (H1N2) in immunized and non-immunized pigs. Virology. 2024 May 23;596:110117.  Abstract  
submitted by kickingbird at May, 29, 2024 from Virology. 2024 May 23;596:110117 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
MicroRNAs (miRNAs) contribute to post-transcriptional modulation of the host response during influenza A virus (IAV) infection and may be involved in shaping disease severity. Differential disease severity ...

Nieves Sevilla, Wendy Lizarraga, Victor Jimenez-Va. Highly pathogenic avian influenza A (H5N1) virus outbreak in Peru in 2022~2023. Infectious Medicine, 2024.  Abstract  
submitted by kickingbird at May, 27, 2024 from Infectious Medicine, 2024 (via https://www.sciencedirect.com/science/article/pii/S2772431X2)
BackgroundAn epizootic of highly pathogenic avian influenza A (H5N1) has spread worldwide since 2022. Even though this virus has been extensively studied for many decades, little is known about its evolution ...

Yanyi Huang, Peiyang Zhang, Shuyi Han, Bin Hu, Qin. Effect of Enteromorpha polysaccharides on gut-lung axis in mice infected with H5N1 influenza virus. Virology, Volume 593, 2024.  Abstract  
submitted by kickingbird at May, 27, 2024 from Virology, Volume 593, 2024 (via https://www.sciencedirect.com/science/article/pii/S004268222)
Enteromorpha polysaccharides (EPPs) have been reported to have antiviral and anti-inflammatory properties. To explore the effect of EPPs on H5N1-infected mice, mice were pretreated with EPPs before being ...

Gonzalez-Obando J, Zuluaga-Cabrera A, Moreno I, ús. First Molecular Detection and Epidemiological Analysis of Equine Influenza Virus in Two Regions of Colombia, 2020~2023. Viruses. 2024; 16(6):839.  Abstract  
submitted by kickingbird at May, 27, 2024 from Viruses. 2024; 16(6):839 (via https://www.mdpi.com/1999-4915/16/6/839)
Equine influenza is a viral disease caused by the equine influenza virus (EIV), and according to the WOAH, it is mandatory to report these infections. In Latin America and Colombia, EIV risk factors have ...

Bernadeta Dadonaite, etc.,al. [preprint]Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance. https://doi.org/10.1101/2024.05.23.595634.  Abstract  
submitted by kickingbird at May, 26, 2024 from https://doi.org/10.1101/2024.05.23.595634 (via https://www.biorxiv.org/content/10.1101/2024.05.23.595634v1)
H5 influenza is considered a potential pandemic threat. Recently, H5 viruses belonging to clade 2.3.4.4b have caused large outbreaks in avian and multiple non-human mammalian species. Previous studies ...

Valerie Le Sage, etc.,al. [preprint]Influenza H5N1 and H1N1 viruses remain infectious in unpasteurized milk on milking machinery surfaces. https://doi.org/10.1101/2024.05.22.24307745.  Abstract  
submitted by kickingbird at May, 25, 2024 from https://doi.org/10.1101/2024.05.22.24307745 (via https://www.medrxiv.org/content/10.1101/2024.05.22.24307745v)
Spillover of highly pathogenic avian H5N1 into the cattle population poses a risk to humans through the close contact with farm workers. High viral loads of influenza viruses in the unpasteurized milk ...

Jinyu Huang, Kaixiong Ma, Jiahao Zhang, Jiangtao Z. Pathogenicity and Transmission of Novel Highly Pathogenic H7N2 Variants Originating from H7N9 Avian Influenza Viruses in Chickens. Virology, 2024.  Abstract  
submitted by kickingbird at May, 25, 2024 from Virology, 2024 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
The H7 subtype avian influenza viruses are circulating widely worldwide, causing significant economic losses to the poultry industry and posing a serious threat to human health. In 2019, H7N2 and H7N9 ...

Nguyen, T.H.O., Rowntree, L.C., Chua, B.Y. et al. Defining the balance between optimal immunity and immunopathology in influenza virus infection. Nat Rev Immunol (2024).  Abstract  
submitted by kickingbird at May, 25, 2024 from Nat Rev Immunol (2024) (via https://link.springer.com/article/10.1038/s41577-024-01029-1)
Influenza A viruses remain a global threat to human health, with continued pandemic potential. In this Review, we discuss our current understanding of the optimal immune responses that drive recovery from ...

Ulupinar, P., ?a?layan, E., Rayaman, E. et al. The mitochondrial carrier homolog 2 is involved in down-regulation of influenza A virus replication. Mol Biol Rep 51, 642 (2024).  Abstract  
submitted by kickingbird at May, 25, 2024 from Mol Biol Rep 51, 642 (2024) (via https://link.springer.com/article/10.1007/s11033-024-09584-5)
BackgroundThe mitochondrial carrier homolog 2 (MTCH2) is a mitochondrial outer membrane protein regulating mitochondrial metabolism and functions in lipid homeostasis and apoptosis. Experimental data on ...

Li, J., Nie, L. Global Dynamics Analysis of Non-Local Delayed Reaction-Diffusion Avian Influenza Model with Vaccination and Multiple Transmission Routes in the Spatial Heterogeneous Environment. Theory Dyn. Syst. 23, 198 (2024).  Abstract  
submitted by kickingbird at May, 25, 2024 from Theory Dyn. Syst. 23, 198 (2024) (via https://link.springer.com/article/10.1007/s12346-024-01057-1)
In order to reveal the transmission dynamics of Avian influenza and explore effective control measures, we develop a non-local delayed reaction-diffusion model of Avian influenza with vaccination and multiple ...

Falcón A, Martínez-Pulgarín S, López-Serrano S, Re. Development of a Fully Protective Pandemic Avian Influenza Subunit Vaccine in Insect Pupae. Viruses. 2024; 16(6):829.  Abstract  
submitted by kickingbird at May, 25, 2024 from Viruses. 2024; 16(6):829 (via https://www.mdpi.com/1999-4915/16/6/829)
In this study, we pioneered an alternative technology for manufacturing subunit influenza hemagglutinin (HA)-based vaccines. This innovative method involves harnessing the pupae of the Lepidoptera Trichoplusia ...

Poulson RL, Reeves AB, Ahlstrom CA, Scott LC, Hubb. Infectivity of Wild-Bird Origin Influenza A Viruses in Minnesota Wetlands across Seasons. Pathogens. 2024 May 14;13(5):406.  Abstract  
submitted by kickingbird at May, 25, 2024 from Pathogens. 2024 May 14;13(5):406 (via https://www.mdpi.com/2076-0817/13/5/406)
The environmental tenacity of influenza A viruses (IAVs) in the environment likely plays a role in their transmission; IAVs are able to remain infectious in aquatic habitats and may have the capacity to ...

WHO team. Genetic and antigenic characteristics of clade 2.3.4.4b A(H5N1) viruses identified in dairy cattle in the United States of America. WHO.  Abstract  
submitted by kickingbird at May, 24, 2024 from WHO (via https://www.who.int/publications/m/item/genetic-and-antigeni)
During 2020, highly pathogenic avian influenza A(H5N1) viruses of clade 2.3.4.4b emerged and rapidly spread across many parts of Africa, Asia and Europe. In late 2021, the 2.3.4.4b A(H5N1) viruses were ...

Schwab LSU, Do THT, Pilapitiya D, Koutsakos M. Dissemination of influenza B virus to the lower respiratory tract of mice is restricted by the interferon response. J Virol. 2024 May 23:e0160423.  Abstract  
submitted by kickingbird at May, 24, 2024 from J Virol. 2024 May 23:e0160423 (via https://journals.asm.org/doi/10.1128/jvi.01604-23)
The global burden of disease caused by influenza B virus (IBV) is substantial; however, IBVs remain overlooked. Understanding host-pathogen interactions and establishing physiologically relevant models ...

Brown JD, Black A, Haman KH, Diel DG, Ramirez VE,. Antibodies to Influenza A(H5N1) Virus in Hunting Dogs Retrieving Wild Fowl, Washington, USA. Emerg Infect Dis. 2024 Jun;30(6):1271-1274.  Abstract  
submitted by kickingbird at May, 24, 2024 from Emerg Infect Dis. 2024 Jun;30(6):1271-1274 (via https://wwwnc.cdc.gov/eid/article/30/6/23-1459_article)
We detected antibodies to H5 and N1 subtype influenza A viruses in 4/194 (2%) dogs from Washington, USA, that hunted or engaged in hunt tests and training with wild birds. Historical data provided by dog ...

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