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2019-7-24 5:10:42
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Carvalho SB, et al. Membrane-based approach for the downstream processing of influenza virus-like particles. Biotechnol J. 2019 May 20:e201800570.  Abstract  
submitted by kickingbird at May, 22, 2019 from Biotechnol J. 2019 May 20:e201800570 (via https://onlinelibrary.wiley.com/doi/abs/10.1002/biot.2018005)
Currently marketed influenza vaccines are only efficient against homologous viruses, thus requiring a seasonal update based on circulating subtypes. This constant reformulation adds several challenges ...

Nishizawa S, et al. Strong binding and off-on signaling functions of deep-red fluorescent TO-PRO-3 for influenza A virus RNA promoter region. Chembiochem. 2019 May 20..  Abstract  
submitted by kickingbird at May, 22, 2019 from Chembiochem. 2019 May 20. (via https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.2019003)
Influenza A virus RNA promoter region has recently attracted much attention as RNA targets for the development of novel anti-influenza drugs. However, there are very limited reports on small RNA-binding ...

Bajic G, et al. Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope. Cell Host Microbe. 2019 May 14.  Abstract  
submitted by kickingbird at May, 22, 2019 from Cell Host Microbe. 2019 May 14 (via https://www.ncbi.nlm.nih.gov/pubmed/31104946)
Viral glycoproteins are under constant immune surveillance by a host's adaptive immune responses. Antigenic variation including glycan introduction or removal is among the mechanisms viruses have evolved ...

Trigueiro-Louro JM, et al. To hit or not to hit: Large-scale sequence analysis and structure characterization of influenza A NS1 unlocks new antiviral target potential. Virology. 2019 Apr 27..  Abstract  
submitted by kickingbird at May, 22, 2019 from Virology. 2019 Apr 27. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza NS1 protein is among the most promising novel druggable anti-influenza target, based on its structure; multiple interactions; and global function in influenza replication and pathogenesis. Notwithstanding, ...

Wu JY, et al. Transmission Risk of Avian Influenza Virus along Poultry Supply Chains in Guangdong, China. J Infect. 2019 May 14..  Abstract  
submitted by kickingbird at May, 20, 2019 from J Infect. 2019 May 14. (via https://www.journalofinfection.com/article/S0163-4453(19)301)
OBJECTIVES: Avian influenza viruses (AIVs) poise significant risk to human health and the poultry industry. We evaluated the transmission risk along the poultry supply chain.METHODS: During October 2015 ...

Zhang W, et al. A hospital cluster combined with a family cluster of avian influenza H7N9 infection in Anhui Province, China. J Infect. 2019 May 14..  Abstract  
submitted by kickingbird at May, 20, 2019 from J Infect. 2019 May 14. (via https://www.journalofinfection.com/article/S0163-4453(19)301)
OBJECTIVES: To identify human-to-human transmission of H7N9 avian influenza virus, we investigated a hospital cluster combined with family cluster in this study.METHODS: We obtained and analyzed clinical, ...

Bangaru S, et al. A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface. Cell. 2019 May 16;177(5):1136-1152.e18..  Abstract  
submitted by kickingbird at May, 20, 2019 from Cell. 2019 May 16;177(5):1136-1152.e18. (via https://www.cell.com/cell/fulltext/S0092-8674(19)30397-6)
Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts with most influenza A ...

Watanabe A, et al. Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism. Cell. 2019 May 16;177(5):1124-1135.e16.  Abstract  
submitted by kickingbird at May, 20, 2019 from Cell. 2019 May 16;177(5):1124-1135.e16 (via https://www.cell.com/cell/fulltext/S0092-8674(19)30349-6)
Vaccines to generate durable humoral immunity against antigenically evolving pathogens such as the influenza virus must elicit antibodies that recognize conserved epitopes. Analysis of single memory B ...

Wu Y, Gao GF. "Breathing" Hemagglutinin Reveals Cryptic Epitopes for Universal Influenza Vaccine Design. Cell. 2019 May 16;177(5):1086-1088..  Abstract  
submitted by kickingbird at May, 20, 2019 from Cell. 2019 May 16;177(5):1086-1088. (via https://www.cell.com/cell/fulltext/S0092-8674(19)30453-2)
A universal vaccine against influenza remains a critical target, and efforts have recently focused on the stem of the hemagglutinin glycoprotein. In this issue of Cell and a related Cell Host & Microbe ...

Lambertz RLO, et al. Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis. J Gen Virol. 2019 May 17..  Abstract  
submitted by kickingbird at May, 20, 2019 from J Gen Virol. 2019 May 17. (via https://jgv.microbiologyresearch.org/content/journal/jgv/10.)
The surface protein haemagglutinin (HA) of influenza A viruses (IAV) needs to be cleaved by a host protease to become functional. Here, we investigated if IAV of the H10 subtype also requires TMPRSS2 for ...

Warfield KL, et al. Lack of selective resistance of influenza A virus in presence of host-targeted antiviral, UV-4B. Sci Rep. 2019 May 16;9(1):7484..  Abstract  
submitted by kickingbird at May, 20, 2019 from Sci Rep. 2019 May 16;9(1):7484. (via https://www.nature.com/articles/s41598-019-43030-y)
Development of antiviral drug resistance is a continuous concern for viruses with high mutation rates such as influenza. The use of antiviral drugs targeting host proteins required for viral replication ...

de Greef JC, et al. Protective role for the N-terminal domain of α-dystroglycan in Influenza A virus proliferation. PNAS 2019 May 16..  Abstract  
submitted by kickingbird at May, 20, 2019 from PNAS 2019 May 16. (via https://www.pnas.org/content/early/2019/05/14/1904493116)
α-Dystroglycan (α-DG) is a highly glycosylated basement membrane receptor that is cleaved by the proprotein convertase furin, which releases its N-terminal domain (α-DGN). Before cleavage, α-DGN interacts ...

Bui CHT, et al. Tropism of influenza B viruses in human respiratory tract explants and airway organoids. Eur Respir J. 2019 May 16..  Abstract  
submitted by kickingbird at May, 20, 2019 from Eur Respir J. 2019 May 16. (via https://erj.ersjournals.com/content/early/2019/05/08/1399300)
Despite causing regular seasonal epidemics with substantial morbidity, mortality and socioeconomic burden, there is still a lack of research on influenza B viruses (IBVs). In this study, we provide for ...

Kudo E, et al. Low ambient humidity impairs barrier function and innate resistance against influenza infection. PNAS USA. 2019 May 13.  Abstract  
submitted by kickingbird at May, 16, 2019 from PNAS USA. 2019 May 13 (via https://www.pnas.org/content/early/2019/05/07/1902840116)
In the temperate regions, seasonal influenza virus outbreaks correlate closely with decreases in humidity. While low ambient humidity is known to enhance viral transmission, its impact on host response ...

Walters KA, et al. Differential Effects of Influenza Virus NA, HA Head, and HA Stalk Antibodies on Peripheral Blood Leukocyte Gene Expression during Human Infection. MBio. 2019 May 14;10(3)..  Abstract  
submitted by kickingbird at May, 16, 2019 from MBio. 2019 May 14;10(3). (via https://mbio.asm.org/content/10/3/e00760-19)
In this study, we examined the relationships between anti-influenza virus serum antibody titers, clinical disease, and peripheral blood leukocyte (PBL) global gene expression during presymptomatic, acute, ...

Lui WY, et al. SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection. Emerg Microbes Infect. 2019;8(1):662-674.  Abstract  
submitted by kickingbird at May, 16, 2019 from Emerg Microbes Infect. 2019;8(1):662-674 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Influenza defective interfering (DI) particles are replication-incompetent viruses carrying large internal deletion in the genome. The loss of essential genetic information causes abortive viral replication, ...

Gahan J, et al. Whole Genome Sequencing of the First H3N8 Equine Influenza Virus Identified in Malaysia. Pathogens. 2019 May 10;8(2)..  Abstract  
submitted by kickingbird at May, 16, 2019 from Pathogens. 2019 May 10;8(2). (via https://www.mdpi.com/2076-0817/8/2/62)
In August 2015, Malaysia experienced an outbreak of acute respiratory disease in racehorses. Clinical signs observed were consistent with equine influenza (EI) infection. The index cases were horses recently ...

Feldman RA, et al. mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials. Vaccine. 2019 May 9..  Abstract  
submitted by kickingbird at May, 15, 2019 from Vaccine. 2019 May 9. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
BACKGROUND: We evaluated safety and immunogenicity of the first mRNA vaccines against potentially pandemic avian H10N8 and H7N9 influenza viruses.METHODS: Two randomized, placebo-controlled, double-blind, ...

Qin C, et al. Close Relationship between cIAP2 and Human ARDS Induced by Severe H7N9 Infection. Biomed Res Int. 2019 Apr 7;2019:2121357.  Abstract  
submitted by kickingbird at May, 15, 2019 from Biomed Res Int. 2019 Apr 7;2019:2121357 (via https://www.hindawi.com/journals/bmri/2019/2121357/)
Background: cIAP2 is involved in necroptosis as a key upstream regulation factor. We aimed to investigate the role of cIAP2 in ARDS/ALI induced by H7N9 virus through regulating the RIPK1/3 necroptosis ...

Xu G, et al. Mutations in PB2 and HA enhanced pathogenicity of H4N6 avian influenza virus in mice. J Gen Virol. 2019 May 13.  Abstract  
submitted by kickingbird at May, 15, 2019 from J Gen Virol. 2019 May 13 (via https://jgv.microbiologyresearch.org/content/journal/jgv/10.)
The H4 subtype avian influenza virus (AIV) continues to circulate in both wild birds and poultry, and occasionally infects mammals (e.g. pigs). H4-specific antibodies have also been detected in poultry ...

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