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2020-8-9 7:55:04
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Hu C, et al. Co-circulation of multiple reassortant H6 subtype avian influenza viruses in wild birds in eastern China, 2016-2017. Virol J. 2020 Apr 29;17(1):62..  Abstract  
submitted by kickingbird at May, 3, 2020 from Virol J. 2020 Apr 29;17(1):62. (via https://www.ncbi.nlm.nih.gov/pubmed/32349760)
BACKGROUND: H6 subtype influenza viruses were prevalent in domestic poultry and wild birds, which also could pose potential threat to humans. However, little is known about the prevalence of H6 subtype ...

Mine J, Uchida Y, Takemae N, Saito T. Genetic characterization of influenza A viruses in Japanese swine during 2015-2019. J Virol. 2020 Apr 29. pii: JVI.02169-19..  Abstract  
submitted by kickingbird at May, 3, 2020 from J Virol. 2020 Apr 29. pii: JVI.02169-19. (via https://www.ncbi.nlm.nih.gov/pubmed/32350072)
To assess the current status of influenza A viruses of swine (IAVs-S) throughout Japan and to investigate how these viruses persisted and evolve on pig farms, we genetically characterized IAVs-S isolated ...

Kesavardhana S, et al. The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development.. J Biol Chem. 2020 Apr 29..  Abstract  
submitted by kickingbird at May, 3, 2020 from J Biol Chem. 2020 Apr 29. (via https://www.jbc.org/content/early/2020/04/29/jbc.RA120.01375)
Z-DNA-binding protein 1 (ZBP1) is an innate immune sensor of nucleic acids that regulates both host defense responses and development. ZBP1 activation triggers inflammation and pyroptosis, necroptosis, ...

Yudhawati R, et al. Comparison of virulence and lethality in mice for two avian influenza A/H5N1 and one A/H3N6 viruses isolated from poultry during 2013 to 2014 in Indonesia. Jpn J Infect Dis. 2020 Apr 30..  Abstract  
submitted by kickingbird at May, 3, 2020 from Jpn J Infect Dis. 2020 Apr 30. (via https://www.jstage.jst.go.jp/article/yoken/advpub/0/advpub_J)
In Indonesia, highly pathogenic avian influenza A/H5N1 virus has become endemic and was linked to direct transmission to humans. During 2013 to 2014, we isolated avian influenza A/H5N1 and A/H3N6 viruses ...

Noll KE, et al. Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross. Cell Rep. 2020 Apr 28;31(4):107587..  Abstract  
submitted by kickingbird at May, 1, 2020 from Cell Rep. 2020 Apr 28;31(4):107587. (via https://www.ncbi.nlm.nih.gov/pubmed/32348764)
Host genetic factors play a fundamental role in regulating humoral immunity to viral infection, including influenza A virus (IAV). Here, we utilize the Collaborative Cross (CC), a mouse genetic reference ...

Filgueiras-Rama D, et al. Human Influenza A virus causes myocardial and cardiac-specific conduction system infection associated with early inflammation and premature death. Cardiovasc Res. 2020 Apr 28.  Abstract  
submitted by kickingbird at May, 1, 2020 from Cardiovasc Res. 2020 Apr 28 (via https://www.ncbi.nlm.nih.gov/pubmed/32346730)
AIMS: Human influenza A virus (hIAV) infection is associated with important cardiovascular complications, although cardiac infection pathophysiology is poorly understood. We aimed to study the ability ...

Zhang Q, et al. Influenza infection elicits an expansion of gut population of endogenous Bifidobacterium animalis which protects mice against infection. Genome Biol. 2020 Apr 28;21(1):99..  Abstract  
submitted by kickingbird at May, 1, 2020 from Genome Biol. 2020 Apr 28;21(1):99. (via https://www.ncbi.nlm.nih.gov/pubmed/32345342)
BACKGROUND: Influenza is a severe respiratory illness that continually threatens global health. It has been widely known that gut microbiota modulates the host response to protect against influenza infection, ...

Abed Y, et al. Characterization of contemporary influenza B recombinant viruses harboring mutations of reduced susceptibility to baloxavir marboxil, in vitro and in mice. Antiviral Res. 2020 Apr 25:104807..  Abstract  
submitted by kickingbird at May, 1, 2020 from Antiviral Res. 2020 Apr 25:104807. (via https://www.ncbi.nlm.nih.gov/pubmed/32343991)
Baloxavir marboxil (BXM) is a potent inhibitor of the polymerase acidic (PA) protein of influenza viruses. However, clinical trials predominantly involving influenza A(H1N1) and A(H3N2) infections showed ...

Guo L, Li N, Li W, Zhou J, Ning R, Hou M, Liu L. New hemagglutinin dual-receptor-binding pattern of a human-infecting influenza A (H7N9) virus isolated after fifth epidemic wave. Virus Evol. 2020 Apr 20;6(1):veaa021.  Abstract  
submitted by kickingbird at May, 1, 2020 from Virus Evol. 2020 Apr 20;6(1):veaa021 (via https://www.ncbi.nlm.nih.gov/pubmed/32337071)
Since 2013, influenza H7N9 virus has caused five epidemic waves of human infection. The virus evolved from low pathogenic to highly pathogenic in wave 5, 2017, while the prevalence of host receptor-binding ...

Arbi M, et al. Historical origins and zoonotic potential of avian influenza virus H9N2 in Tunisia revealed by Bayesian analysis and molecular characterization. Arch Virol. 2020 Apr 25..  Abstract  
submitted by kickingbird at May, 1, 2020 from Arch Virol. 2020 Apr 25. (via https://www.ncbi.nlm.nih.gov/pubmed/32335769)
During 2009-2012, several outbreaks of avian influenza virus H9N2 were reported in Tunisian poultry. The circulating strains carried in their hemagglutinins the human-like marker 226L, which is known to ...

Wandzik JM, Kouba T, Cusack S. Structure and Function of Influenza Polymerase. Cold Spring Harb Perspect Med. 2020 Apr 27..  Abstract  
submitted by kickingbird at May, 1, 2020 from Cold Spring Harb Perspect Med. 2020 Apr 27. (via http://perspectivesinmedicine.cshlp.org/content/early/2020/0)
Influenza polymerase (FluPol) plays a key role in the viral infection cycle by transcribing and replicating the viral genome. FluPol is a multifunctional, heterotrimeric enzyme with cap-binding, endonuclease, ...

Rivas MJ, et al. Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012-2019. Microorganisms. 2020 Apr 19;8(4)..  Abstract  
submitted by kickingbird at Apr, 30, 2020 from Microorganisms. 2020 Apr 19;8(4). (via https://www.ncbi.nlm.nih.gov/pubmed/32325860)
Influenza B viruses (IBV) are an important cause of morbidity and mortality during interpandemic periods in the human population. Two phylogenetically distinct IBV lineages, B/Yamagata and B/Victoria, ...

Prokopyeva E, et al. Experimental Infection Using Mouse-Adapted Influenza B Virus in a Mouse Model. Viruses. 2020 Apr 21;12(4)..  Abstract  
submitted by kickingbird at Apr, 30, 2020 from Viruses. 2020 Apr 21;12(4). (via https://www.ncbi.nlm.nih.gov/pubmed/32326238)
Every year, influenza B viruses (IBVs) contribute to annual illness, and infection can lead to serious respiratory disease among humans. More attention is needed in several areas, such as increasing virulence ...

Lei N, et al. IFITM3 Affects the Level of Antibody Response after Influenza Vaccination. Emerg Microbes Infect. 2020 Apr 23:1-29.  Abstract  
submitted by kickingbird at Apr, 24, 2020 from Emerg Microbes Infect. 2020 Apr 23:1-29 (via https://www.ncbi.nlm.nih.gov/pubmed/32321380)
Interferon-induced transmembrane protein 3 (IFITM3) as an antiviral factor can inhibit replication of several viruses including influenza virus. A single-nucleotide polymorphism rs12252-C of IFITM3 results ...

Lambertz RLO, et al. H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice. Virol J. 2020 Apr 22;17(1):56.  Abstract  
submitted by kickingbird at Apr, 24, 2020 from Virol J. 2020 Apr 22;17(1):56 (via https://www.ncbi.nlm.nih.gov/pubmed/32321537)
The host cell protease TMPRSS2 cleaves the influenza A virus (IAV) hemagglutinin (HA). Several reports have described resistance of Tmprss2-/- knock-out (KO) mice to IAV infection but IAV of the H2 subtype ...

Rahim MMA, et al. Defective influenza A virus RNA products mediate MAVS-dependent upregulation of human leukocyte antigen class I proteins. J Virol. 2020 Apr 22. pii: JVI.00165-20.  Abstract  
submitted by kickingbird at Apr, 24, 2020 from J Virol. 2020 Apr 22. pii: JVI.00165-20 (via https://www.ncbi.nlm.nih.gov/pubmed/32321802)
Influenza A virus (IAV) increases presentation of class I human leukocyte antigen (HLA) proteins that limit antiviral responses mediated by natural killer (NK) cells, but molecular mechanisms have not ...

Verhagen JH, et al. Phylogeography and antigenic diversity of low pathogenic avian influenza H13 and H16 viruses. J Virol. 2020 Apr 22. pii: JVI.00537-20..  Abstract  
submitted by kickingbird at Apr, 24, 2020 from J Virol. 2020 Apr 22. pii: JVI.00537-20. (via https://www.ncbi.nlm.nih.gov/pubmed/32321814)
Low pathogenic avian influenza viruses (LPAIVs) are genetically highly variable and have diversified into multiple evolutionary lineages that are primarily associated with wild bird reservoirs. Antigenic ...

Kim HO, et al. Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza Virus via a Viral Fusion and Cell Entry Mechanism. Adv Funct Mater. 2018 Aug 22;28(34):1800960.  Abstract  
submitted by kickingbird at Apr, 23, 2020 from Adv Funct Mater. 2018 Aug 22;28(34):1800960 (via https://www.ncbi.nlm.nih.gov/pubmed/32313543)
Highly pathogenic avian influenza virus (HPAIV) infections have occurred continuously and crossed the species barrier to humans, leading to fatalities. A polymerase chain reaction based molecular test ...

Whitman J, Jayaprakash C. Stochastic modeling of influenza spread dynamics with recurrences. PLoS One. 2020 Apr 21;15(4):e0231521.  Abstract  
submitted by kickingbird at Apr, 23, 2020 from PLoS One. 2020 Apr 21;15(4):e0231521 (via https://www.ncbi.nlm.nih.gov/pubmed/32315318)
We present results of a study of a simple, stochastic, agent-based model of influenza A infection, simulating its dynamics over the course of one flu season. Building on an early work of Bartlett, we define ...

Wu J, et al. Disulfide isomerase ERp57 improves the stability and immunogenicity of H3N2 influenza virus hemagglutinin. Virol J. 2020 Apr 21;17(1):55..  Abstract  
submitted by kickingbird at Apr, 23, 2020 from Virol J. 2020 Apr 21;17(1):55. (via https://www.ncbi.nlm.nih.gov/pubmed/32316996)
BACKGROUND: Hemagglutinin (HA), as the surface immunogenic protein, is the most important component of influenza viruses. Previous studies showed that the stability of HA was significant for HA's immunogenicity, ...

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