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2026-2-12 8:03:59
Article

Peng J, Miao X, Zhang X, Li Z, Wang Y, Liu G, Na L. Molecular Characterization of an H3N2 Canine Influenza Virus Isolated from a Dog in Jiangsu, China, in 2025. Veterinary Sciences. 2026; 13(1):32.  Abstract  
submitted by kickingbird at Dec, 31, 2025 from Veterinary Sciences. 2026; 13(1):32 (via https://www.mdpi.com/2306-7381/13/1/32)
To investigate the molecular characteristics of H3N2 canine influenza viruses circulating in Jiangsu, China, we isolated a H3N2 strain (A/Canine/Nanjing/CnNj01-2025) from a dog presenting with respiratory ...

Alekseev A, Sobolev I, Sharshov K, Gulyaeva M, Kur. Pathobiology of Highly Pathogenic Avian Influenza A (H5N1 Clade 2.3.4.4b) Virus from Pinnipeds on Tyuleniy Island in the Sea of Okhotsk, Russia. Viruses. 2026; 18(1):51.  Abstract  
submitted by kickingbird at Dec, 31, 2025 from Viruses. 2026; 18(1):51 (via https://www.mdpi.com/1999-4915/18/1/51)
Highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b has recently emerged as a major threat to wildlife, agriculture, and public health due to its expanding host range and the increasing frequency ...

Yuwen Luo, etc.,al. Impact of viral Ribonucleoprotein Complex Genetic Stability on Pathogenicity in H9N2 and H6N2 Avian Influenza Viruses. Developmental & Comparative Immunology.  Abstract  
submitted by kickingbird at Dec, 28, 2025 from Developmental & Comparative Immunology (via https://www.sciencedirect.com/science/article/abs/pii/S01453)
China has a great demand for poultry, while avian influenza (AI) remains widespread and exhibits high instability, posing a persistent challenge to the poultry industry. Elucidating the genetic stability ...

Harrell T.L., Shwani A., Suarez D.L. The Impact of Acids, pH, and Incubation Time on Avian Influenza Virus Persistence in Raw Milk. Food Microbiology.  Abstract  
submitted by kickingbird at Dec, 28, 2025 from Food Microbiology (via https://www.sciencedirect.com/science/article/abs/pii/S07400)
In March 2024, highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4.b H5N1 was detected in dairy cattle. Since detection, the virus has spread across 17 states, infecting more than 1000 dairy ...

Ane Marie Anderson, etc.,al. DNA vaccines targeting hemagglutinin from 18 subtypes of influenza A virus to antigen presenting cells confer broad protection. Molecular Therapy Nucleic Acids.  Abstract  
submitted by kickingbird at Dec, 28, 2025 from Molecular Therapy Nucleic Acids (via https://www.sciencedirect.com/science/article/pii/S216225312)
Novel vaccines that confer broad protection against influenza A viruses (IAV) are urgently needed. Hemagglutinin (HA) is the major influenza antigen targeted by protective immune responses. We have here ...

Zhu, T., Zhu, M., Lu, F. et al. Pre-activation timing determines influenza severity and viral pathogenicity via STING Inhibition. Sci Rep 15, 44501 (2025).  Abstract  
submitted by kickingbird at Dec, 28, 2025 from Sci Rep 15, 44501 (2025) (via https://www.nature.com/articles/s41598-025-28063-w)
Severe influenza is frequently associated with bacterial or viral co-infections. Although immune-mediated mechanisms have been extensively investigated, the cell-intrinsic responses of respiratory epithelial ...

Yang G, Chen P-L, Rovito SW, Minari K, Writt HN, D. Resistance Mutations to Broadly Neutralizing Antibodies Destabilize Hemagglutinin and Attenuate H1N1 Influenza Virus. Viruses. 2026; 18(1):32.  Abstract  
submitted by kickingbird at Dec, 25, 2025 from Viruses. 2026; 18(1):32 (via https://www.mdpi.com/1999-4915/18/1/32)
Because antigenic drift primarily generates amino-acid changes in the membrane-distal hemagglutinin (HA) head, broadly neutralizing antibodies (bNAbs) are being developed to target conserved epitopes in ...

Mengdi Guan, etc.,al. Genetic diversity of H13 avian influenza viruses in migratory shorebirds in eastern China. Journal of Integrative Agriculture.  Abstract  
submitted by kickingbird at Dec, 25, 2025 from Journal of Integrative Agriculture (via https://www.sciencedirect.com/science/article/pii/S209531192)
Highlights1.Twenty one H13 subtype avian influenza viruses were isolated from 50016 samples in migratory birds during 2017 to 2024 in Shandong Province, China2.The H13 viruses were mainly harbored by shorebirds ...

Alvin Crespo-Bellido, etc.,al. [preprint]Emergence of D1.1 reassortant H5N1 avian influenza viruses in North America. https://doi.org/10.64898/2025.12.19.695329.  Abstract  
submitted by kickingbird at Dec, 24, 2025 from https://doi.org/10.64898/2025.12.19.695329 (via https://www.biorxiv.org/content/10.64898/2025.12.19.695329v1)
Since 2021, highly pathogenic avian influenza viruses (HPAIV) belonging to H5N1 clade 2.3.4.4b have caused high mortality in North American wild birds and poultry. In 2025, a new D1.1 genotype caused two ...

Song Y, Yan A, Song S, Gong H, Chen L, Fu B, Zhang. Phylogenetic Analyses and Biological Characterization of H9N2 Avian Influenza Virus Isolated from Chickens in China from 2022 to 2023. Microorganisms. 2026; 14(1):37.  Abstract  
submitted by kickingbird at Dec, 24, 2025 from Microorganisms. 2026; 14(1):37 (via https://www.mdpi.com/2076-2607/14/1/37)
The continued diversification of the H9N2 avian influenza virus (AIV) into multiple antigenically and phylogenetically distinct lineages is promoting the emergence of strains with pandemic potential. Constant ...

Schmierer J, Lutz M, Takimoto T. 0. Enhanced genome replication activity of pandemic H1N1 influenza A virus through PA mutations. J Virol 0:e01391-25.  Abstract  
submitted by kickingbird at Dec, 24, 2025 from J Virol 0:e01391-25 (via https://journals.asm.org/doi/10.1128/jvi.01391-25)
The 2009 pandemic H1N1 (pH1N1) influenza A virus (IAV) is a reassortant virus with two polymerase components, PA and PB2, originating from avian IAV. Avian IAV polymerase does not function efficiently ...

Jeffery D. Sullivan, etc.,al. Rapid increase in antibodies to influenza A virus H5 and N1 in Lesser Scaup (Aythya affinis) following the introduction of 2.3.4.4b H5N1 into North America. Canadian Journal of Microbiology.  Abstract  
submitted by kickingbird at Dec, 24, 2025 from Canadian Journal of Microbiology (via https://www.sciencedirect.com/org/science/article/pii/S00084)
Clade 2.3.4.4b Eurasian-origin H5N1 entered North America in late 2021 and spread across the continent. While studies have characterized the antibody response mounted by dabbling ducks following exposure, ...

Shu Zhou, Rute Maria Pinto, Hou Wei Chook, Eleanor. [preprint]Identification of cis-Acting Elements that Regulate Influenza A Virus Segment 7 Differential mRNA Splicing. https://doi.org/10.64898/2025.12.22.695654.  Abstract  
submitted by kickingbird at Dec, 23, 2025 from https://doi.org/10.64898/2025.12.22.695654 (via https://www.biorxiv.org/content/10.64898/2025.12.22.695654v1)
Influenza A virus segment 7 encodes the M1 matrix protein and M2 ion channel from an unspliced primary transcript mRNA1 and spliced mRNA2, respectively. Both proteins are essential for efficient virus ...

Gabriela J. Rzeszutek, etc.,al. [preprint]Zoonotic and Avian Pathogen Detections in Fecal and Sediment Samples - A Low-risk, High-throughput One Health Approach to Surveillance. https://doi.org/10.64898/2025.12.19.694637.  Abstract  
submitted by kickingbird at Dec, 23, 2025 from https://doi.org/10.64898/2025.12.19.694637 (via https://www.biorxiv.org/content/10.64898/2025.12.19.694637v1)
Many pathogens, both those with human spillover potential as well as avian-specific viruses, are maintained in wild bird populations. While much surveillance for influenza A viruses (IAVs) is performed ...

Song Y, Song S, Yan A, Gong H, Yang H, Guan F, Zha. A Novel Recombinant Chicken-Derived H6N8 Subtype Avian Influenza Virus Caused Disease in Chickens and Mice. Viruses. 2026; 18(1):12.  Abstract  
submitted by kickingbird at Dec, 22, 2025 from Viruses. 2026; 18(1):12 (via https://www.mdpi.com/1999-4915/18/1/12)
H6 subtype avian influenza viruses (AIVs) have a broader host range and circulate globally in wild birds, domestic ducks, geese, and terrestrial poultry all over the world. Their demonstrated capacity ...

Lee N, Tang JW, Chon I, Kakuya F, Terao R, Kawashi. Influenza PA Substitutions and Genetic Diversity of A(H1N1)pdm09, A(H3N2), and B/Victoria Viruses in Japan During the 2023–2024 Season. Viruses. 2026; 18(1):13.  Abstract  
submitted by kickingbird at Dec, 22, 2025 from Viruses. 2026; 18(1):13 (via https://www.mdpi.com/1999-4915/18/1/13)
We characterized influenza A(H1N1)pdm09, A(H3N2), and B/Victoria viruses circulating in Japan during 2023–2024, focusing on lineage placement relative to WHO-recommended vaccine strains and on baloxavir ...

Zhang, L., Lai, Y., Cui, Y. et al. Emergence of mammalian-adaptive PB2 mutations enhances polymerase activity and pathogenicity of cattle-derived H5N1 influenza A virus. Nat Commun (2025).  Abstract  
submitted by kickingbird at Dec, 22, 2025 from Nat Commun (2025) (via https://www.nature.com/articles/s41467-025-67753-x)
Highly pathogenic avian influenza H5N1 poses an increasing public health risk, particularly following its spillover into dairy cows and associated human infections in the U.S. since March 2024. Here, we ...

Du, F., Zhang, Q., Cheng, Y. et al. A taxonomically harmonized global dataset of wild bird hosts for avian influenza virus surveillance. Sci Data (2025).  Abstract  
submitted by kickingbird at Dec, 21, 2025 from Sci Data (2025) (via https://www.nature.com/articles/s41597-025-06451-1)
Wild birds are key natural reservoirs and play a central role in the global spread of avian influenza viruses (AIVs). However, the absence of a standardized global list of wild bird hosts has limited comprehensive ...

Rogan A. Grant, etc.,al. [preprint]Influenza A infection accelerates disease-associated microglia formation during physiological aging. https://doi.org/10.64898/2025.12.11.693336.  Abstract  
submitted by kickingbird at Dec, 20, 2025 from https://doi.org/10.64898/2025.12.11.693336 (via https://www.biorxiv.org/content/10.64898/2025.12.11.693336v1)
Severe pneumonia is associated with an increased risk of cognitive decline and dementia, particularly in the elderly. Changes in microglia, the most abundant immune cell population in the brain, are also ...

Zhang, J., Xue, Q., Wang, X. et al. Chicken PIAS2 enhances H6N2 avian influenza virus replication by promoting SUMOylation of viral NP. Vet Res (2025).  Abstract  
submitted by kickingbird at Dec, 20, 2025 from Vet Res (2025) (via https://link.springer.com/article/10.1186/s13567-025-01702-w)
Avian influenza virus (AIV) is a significant zoonotic pathogen that causes infectious disease in various species and poses a serious threat to both the poultry industry and public health. Mammalian protein ...

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