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2024-11-1 8:12:30
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Liu L, Chen G, Huang S, Wen F. Receptor Binding Properties of Neuraminidase for influenza A virus: An Overview of Recent Research Advances. Virulence. 2023 Dec;14(1):2235459.  Abstract  
submitted by kickingbird at Jul, 21, 2023 from Virulence. 2023 Dec;14(1):2235459 (via https://www.tandfonline.com/doi/full/10.1080/21505594.2023.2)
Influenza A viruses (IAVs) pose a serious risk to both human and animal health. IAVs' receptor binding characteristics account for a major portion of their host range and tissue tropism. While the function ...

El Sahly HM, Yildirim I, Frey SE, Winokur P, Jacks. Safety and Immunogenicity of a Delayed Heterologous Avian Influenza A(H7N9) Vaccine Boost Following Different Priming Regimens: A Randomized Clinical Trial. J Infect Dis. 2023 Jul 19:jiad276.  Abstract  
submitted by kickingbird at Jul, 20, 2023 from J Infect Dis. 2023 Jul 19:jiad276 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
Background: Influenza A (H7N9) has caused multiple disease waves with evidence of strain diversification. Optimal influenza A (H7N9) prime-boost vaccine strategies are unknown.Methods: We recruited participants ...

Liu M, Bakker AS, Narimatsu Y, van Kuppeveld FJM,. H3N2 influenza A virus gradually adapts to human-type receptor binding and entry specificity after the start of the 1968 pandemic. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e230499.  Abstract  
submitted by kickingbird at Jul, 20, 2023 from Proc Natl Acad Sci U S A. 2023 Aug;120(31):e230499 (via https://www.pnas.org/doi/10.1073/pnas.2304992120)
To become established upon zoonotic transfer, influenza A viruses (IAV) need to switch binding from "avian-type" α2-3-linked sialic acid receptors (2-3Sia) to "human-type" Siaα2-6-linked sialic acid receptors ...

Noh EB, Heo GB, Lee KN, Kang YM, An SH, Kim NY, Le. Subtype specific virus enrichement with immunomagnetic separation method followed by NGS unravels the mixture of H5 and H9 avian influenza virus. J Virol Methods. 2023 Jul 17:114773.  Abstract  
submitted by kickingbird at Jul, 20, 2023 from J Virol Methods. 2023 Jul 17:114773 (via https://www.sciencedirect.com/science/article/abs/pii/S01660)
Wild bird avian influenza virus (AIV) surveillance is important for the early detection of highly pathogenic AIVs and for providing early warnings to the poultry industry and veterinary services to implement ...

Waqas FH, Shehata M, Elgaher WAM, Lacour A, Kurmas. NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner. PLoS Pathog. 2023 Jul 17;19(7):e1011506.  Abstract  
submitted by kickingbird at Jul, 18, 2023 from PLoS Pathog. 2023 Jul 17;19(7):e1011506 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
In addition to antioxidative and anti-inflammatory properties, activators of the cytoprotective nuclear factor erythroid-2-like-2 (NRF2) signaling pathway have antiviral effects, but the underlying antiviral ...

Kang M, Lin F, Jiang Z, Tan X, Lin X, Liang Z, Xia. The impact of pre-existing influenza antibodies and inflammatory status on the influenza vaccine responses in older adults. Influenza Other Respir Viruses. 2023 Jul 12;17(7):.  Abstract  
submitted by kickingbird at Jul, 17, 2023 from Influenza Other Respir Viruses. 2023 Jul 12;17(7): (via https://onlinelibrary.wiley.com/doi/10.1111/irv.13172)
Age-associated immune changes and pre-existing influenza immunity are hypothesized to reduce influenza vaccine effectiveness in older adults, although the contribution of each factor is unknown. Here, ...

Sun L, Kong H, Yu M, Zhang Z, Zhang H, Na L, Qu Y,. The SUMO-interacting motif in NS2 promotes adaptation of avian influenza virus to mammals. Sci Adv. 2023 Jul 14;9(28):eadg5175.  Abstract  
submitted by kickingbird at Jul, 14, 2023 from Sci Adv. 2023 Jul 14;9(28):eadg5175 (via https://www.science.org/doi/10.1126/sciadv.adg5175)
Species differences in the host factor ANP32A/B result in the restriction of avian influenza virus polymerase (vPol) in mammalian cells. Efficient replication of avian influenza viruses in mammalian cells ...

Kleinehr J, Sch?fb?nker M, Daniel K, Günl F, Moham. Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA. PLoS Pathog. 2023 Jul 13;19(7):e1010986.  Abstract  
submitted by kickingbird at Jul, 14, 2023 from PLoS Pathog. 2023 Jul 13;19(7):e1010986 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A virus (IAV), like any other virus, provokes considerable modifications of its host cell's metabolism. This includes a substantial increase in the uptake as well as the metabolization of glucose. ...

Herfst S, Begeman L, Spronken MI, Poen MJ, Eggink. A Dutch highly pathogenic H5N6 avian influenza virus showed remarkable tropism for extra-respiratory organs and caused severe disease but was not transmissible via air in the ferret model. mSphere. 2023 Jul 10:e0020023.  Abstract  
submitted by kickingbird at Jul, 11, 2023 from mSphere. 2023 Jul 10:e0020023 (via https://journals.asm.org/doi/10.1128/msphere.00200-23)
Continued circulation of A/H5N1 influenza viruses of the A/goose/Guangdong/1/96 lineage in poultry has resulted in the diversification in multiple genetic and antigenic clades. Since 2009, clade 2.3.4.4 ...

Olajide OM, Osman MK, Robert J, Kessler S, Toews L. Evolutionarily conserved amino acids in MHC-II mediate bat influenza A virus entry into human cells. PLoS Biol. 2023 Jul 6;21(7):e3002182.  Abstract  
submitted by kickingbird at Jul, 7, 2023 from PLoS Biol. 2023 Jul 6;21(7):e3002182 (via https://journals.plos.org/plosbiology/article?id=10.1371/jou)
The viral hemagglutinins of conventional influenza A viruses (IAVs) bind to sialylated glycans on host cell surfaces for attachment and subsequent infection. In contrast, hemagglutinins of bat-derived ...

Li H, Dong W, Wang J, Yu D, Qian D, Yue L, Jiu Y,. The global epidemic trend analysis of influenza type B drug resistance sites from 2006 to 2018. J Infect Dev Ctries. 2023 Jun 30;17(6):868-873.  Abstract  
submitted by kickingbird at Jul, 6, 2023 from J Infect Dev Ctries. 2023 Jun 30;17(6):868-873 (via https://www.jidc.org/index.php/journal/article/view/17410)
Introduction: Influenza is a severe respiratory viral infection that causes significant morbidity and mortality, due to annual epidemics and unpredictable pandemics. With the extensive use of neuraminidase ...

He Z, Wang X, Lin Y, Feng S, Huang X, Zhao L, Zhan. Genetic characteristics of waterfowl-origin H5N6 highly pathogenic avian influenza viruses and their pathogenesis in ducks and chickens. Front Microbiol. 2023 Jun 15;14:1211355.  Abstract  
submitted by kickingbird at Jul, 6, 2023 from Front Microbiol. 2023 Jun 15;14:1211355 (via https://www.frontiersin.org/articles/10.3389/fmicb.2023.1211)
Waterfowl, such as ducks, are natural hosts for avian influenza viruses (AIVs) and act as a bridge for transmitting the virus to humans or susceptible chickens. Since 2013, chickens and ducks have been ...

Zhu W, Chen Q, Xu X, Wei H, Tan M, Yang L, Zou S,. Biological features of human influenza A(H3N8) viruses in China. Zhu W, Chen Q, Xu X, Wei H, Tan M, Yang L, Zou S,.  Abstract  
submitted by kickingbird at Jul, 6, 2023 from Zhu W, Chen Q, Xu X, Wei H, Tan M, Yang L, Zou S, (via https://onlinelibrary.wiley.com/doi/10.1002/jmv.28912)
Influenza A(H3N8) viruses first emerged in humans in 2022, but their public health risk has not been evaluated. Here, we systematically investigated the biological features of avian and human isolated ...

Yang H, Dong Y, Bian Y, Huo C, Zhu C, Qin T, Chen. The synergistic effect of residues 32T and 550L in the PA protein of H5 subtype avian influenza virus contributes to viral pathogenicity in mice. PLoS Pathog. 2023 Jul 3;19(7):e1011489.  Abstract  
submitted by kickingbird at Jul, 4, 2023 from PLoS Pathog. 2023 Jul 3;19(7):e1011489 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
The avian influenza virus (AIV) PA protein contributes to viral replication and pathogenicity; however, its interaction with innate immunity is not well understood. Here, we report that the H5 subtype ...

Park J, Song CS, Chung DH, Choi S, Kwon J, Youk S,. Chimeric H5 influenza virus-like particle vaccine elicits broader cross-clade antibody responses in chickens than in ducks. Front Vet Sci. 2023 Jun 15;10:1158233.  Abstract  
submitted by kickingbird at Jul, 4, 2023 from Front Vet Sci. 2023 Jun 15;10:1158233 (via https://www.frontiersin.org/articles/10.3389/fvets.2023.1158)
Eurasian-lineage highly pathogenic avian influenza (HPAI) H5 viruses have spread throughout Asia, the Middle East, Europe, Africa, and most recently, North and South America. These viruses are independently ...

Yin Y, Qiu Z, Lei Y, Huang J, Sun Y, Liu H, Wu W,. Screening and identification of specific cluster miRNAs in N2a cells infected by H7N9 virus. Virus Genes. 2023 Jul 3.  Abstract  
submitted by kickingbird at Jul, 4, 2023 from Virus Genes. 2023 Jul 3 (via https://link.springer.com/article/10.1007/s11262-023-01996-y)
This study aims to screen and identify specific cluster miRNAs of H7N9 virus-infected N2a cells and explore the possible pathogenesis of these miRNAs. The N2a cells are infected with H7N9 and H1N1 influenza ...

Li Y, Liu P, Hao T, Liu S, Wang X, Xie Y, Xu K, Le. Rational design of an influenza-COVID-19 chimeric protective vaccine with S-RBD and HA-stalk. Emerg Microbes Infect. 2023 Jul 3:2231573.  Abstract  
submitted by kickingbird at Jul, 4, 2023 from Emerg Microbes Infect. 2023 Jul 3:2231573 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2)
Highly contagious respiratory illnesses like influenza and COVID-19 pose serious risks to public health. A two-in-one vaccine would be ideal to avoid multiple vaccinations for these diseases. Here, we ...

McMahon A, Andrews R, Groves D, Ghani SV, Cordes T. High-throughput super-resolution analysis of influenza virus pleomorphism reveals insights into viral spatial organization. PLoS Pathog. 2023 Jun 30;19(6):e1011484.  Abstract  
submitted by kickingbird at Jul, 1, 2023 from PLoS Pathog. 2023 Jun 30;19(6):e1011484 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Many viruses form highly pleomorphic particles. In influenza, virion structure is of interest not only in the context of virus assembly, but also because pleomorphic variations may correlate with infectivity ...

Pinto RM, Bakshi S, Lytras S, Zakaria MK, Swingler. BTN3A3 evasion promotes the zoonotic potential of influenza A viruses. Nature. 2023 Jun 28.  Abstract  
submitted by kickingbird at Jun, 30, 2023 from Nature. 2023 Jun 28 (via https://www.nature.com/articles/s41586-023-06261-8)
Spillover events of avian influenza A viruses (IAVs) to humans could represent the first step in a future pandemic1. Several factors that limit the transmission and replication of avian IAVs in mammals ...

Kim JY, Lee SH, Kim DW, Lee DW, Song CS, Lee DH, K. Detection of intercontinental reassortant H6 avian influenza viruses from wild birds in South Korea, 2015 and 2017. Front Vet Sci. 2023 Jun 12;10:1157984.  Abstract  
submitted by kickingbird at Jun, 30, 2023 from Front Vet Sci. 2023 Jun 12;10:1157984 (via https://www.frontiersin.org/articles/10.3389/fvets.2023.1157)
Avian influenza viruses (AIVs) in wild birds are phylogenetically separated in Eurasian and North American lineages due to the separated distribution and migration of wild birds. However, AIVs are occasionally ...

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