Kadam RU, Wilson IA. A small-molecule fragment that emulates binding of receptor and broadly neutralizing antibodies to influenza A hemagglutinin. PNAS. 2018 Apr 2. Abstract
submitted by kickingbird at Apr, 8, 2018 from PNAS. 2018 Apr 2 (via https://www.ncbi.nlm.nih.gov/pubmed/29610325)
The influenza virus hemagglutinin (HA) glycoprotein mediates receptor binding and membrane fusion during viral entry in host cells. Blocking these key steps in viral infection has applications for development ... Yao-Qing Chen, etc.,al. Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies. Cell Vol 173, Issue 2, p417–429.e10, 5 April 2018. Abstract
submitted by kickingbird at Apr, 6, 2018 from Cell Vol 173, Issue 2, p417–429.e10, 5 April 2018 (via http://www.cell.com/cell/fulltext/S0092-8674(18)30310-6)
Antibodies to the hemagglutinin (HA) and neuraminidase (NA) glycoproteins are the major mediators of protection against influenza virus infection. Here, we report that current influenza vaccines poorly ... Melissa A Rolfes, etc.,al. Influenza-Associated Parotitis During the 2014~2015 Influenza Season in the United States. Clinical Infectious Diseases 30 Mar 2018. Abstract
submitted by kickingbird at Apr, 6, 2018 from Clinical Infectious Diseases 30 Mar 2018 (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
BackgroundDuring the 2014–2015 influenza season in the United States, 256 cases of influenza-associated parotitis were reported from 27 states. We conducted a case-control study and laboratory investigation ... Masato Hatta, Gongxun Zhong, Yuwei Gao,etc.,al. Characterization of a Feline Influenza A(H7N2) Virus. EID Vol 24, Number 1,Jan 2018. Abstract
submitted by kickingbird at Apr, 4, 2018 from EID Vol 24, Number 1,Jan 2018 (via https://wwwnc.cdc.gov/eid/article/24/1/17-1240_article)
During December 2016–February 2017, influenza A viruses of the H7N2 subtype infected ≈500 cats in animal shelters in New York, NY, USA, indicating virus transmission among cats. A veterinarian who treated ... Isakova-Sivak I, Korenkov D, Smolonogina T, Kotomi. Broadly protective anti-hemagglutinin stalk antibodies induced by live attenuated influenza vaccine expressing chimeric hemagglutinin. Virology 2018;518:313-323. Abstract
submitted by kickingbird at Apr, 3, 2018 from Virology 2018;518:313-323 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29574336/)
The development of influenza vaccines that can provide broad protection against all drifted seasonal virus variants, zoonotic infections and emerging pandemic strains, has been a priority for two decades. ... van de Sandt CE, Pronk MR, van Baalen CA, Fouchier. Variation at extra-epitopic amino acid residues influences suppression of influenza virus replication by M158-66 epitope-specific CD8+ T lymphocytes. J Virol 2018 Mar 28. Abstract
submitted by kickingbird at Apr, 3, 2018 from J Virol 2018 Mar 28 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29593036/)
Influenza virus-specific CD8+ T lymphocytes (CTL) contribute to clearance of influenza virus infections and reduce disease severity. Variation at amino acid residues located in- or outside CTL epitopes ... Wang W, Song HS, Keller PW, Alvarado-Facundo E, et. Conformational stability of the hemagglutinin of H5N1 influenza A viruses influences susceptibility to broadly neutralizing stem antibodies. J Virol 2018 Mar 28. Abstract
submitted by kickingbird at Apr, 3, 2018 from J Virol 2018 Mar 28 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29593038/)
Vaccines that elicit broadly neutralizing antibodies to the conserved stem of hemagglutinin (HA) are being developed as universal influenza vaccines that protect against influenza across multiple years. ... Wen L, Chu H, Wong BH, Wang D, Li C. Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses. Emerg Microbes Infect. 2018 Mar 29;7(1):47. Abstract
submitted by kickingbird at Apr, 2, 2018 from Emerg Microbes Infect. 2018 Mar 29;7(1):47 (via https://www.ncbi.nlm.nih.gov/pubmed/29593225)
To elucidate the adaptive strategies of influenza A viruses (IAVs) to human, we proposed a computational approach to identify human-adaptive mutations in seasonal IAVs, which have not been analyzed comprehensively. ... Peng X, Liu F, Wu H, Peng X, Xu Y, Wang L. Amino Acid Substitutions HA A150V, PA A343T, and PB2 E627K Increase the Virulence of H5N6 Influenza Virus in Mice. Front Microbiol. 2018 Mar 13;9:453. Abstract
submitted by kickingbird at Apr, 2, 2018 from Front Microbiol. 2018 Mar 13;9:453 (via https://www.ncbi.nlm.nih.gov/pubmed/29593694)
H5N6 avian influenza viruses (AIVs) can cause severe pneumonia and death in humans. However, the molecular determinants of H5N6 influenza virus mammalian adaption are still unclear. Three amino acid substitutions ... Takemae N, Tsunekuni R, Uchida Y, Ito T, Saito T. Experimental infection of pigs with H1 and H3 influenza A viruses of swine by using intranasal nebulization. BMC Vet Res. 2018 Mar 27;14(1):115. Abstract
submitted by kickingbird at Apr, 2, 2018 from BMC Vet Res. 2018 Mar 27;14(1):115 (via https://www.ncbi.nlm.nih.gov/pubmed/29587842)
BACKGROUND: Experimental infection of pigs via direct intranasal or intratracheal inoculation has been mainly used to study the infectious process of influenza A viruses of swine (IAVs-S). Nebulization ... Trapp S, Soubieux D, etc.,al. Major contribution of the RNA-binding domain of NS1 in the pathogenicity and replication potential of an avian H7N1 influenza virus in chickens. Virol J. 2018 Mar 27;15(1):55. Abstract
submitted by kickingbird at Apr, 2, 2018 from Virol J. 2018 Mar 27;15(1):55 (via https://www.ncbi.nlm.nih.gov/pubmed/29587792)
BACKGROUND: Non-structural protein NS1 of influenza A viruses harbours several determinants of pathogenicity and host-range. However it is still unclear to what extent each of its two structured domains ... Cheng J, Zhang C, Tao J, Li B, Shi Y, Liu H. Effects of the S42 residue of the H1N1 swine influenza virus NS1 protein on interferon responses and virus replication. Virol J. 2018 Mar 27;15(1):57. Abstract
submitted by kickingbird at Apr, 2, 2018 from Virol J. 2018 Mar 27;15(1):57 (via https://www.ncbi.nlm.nih.gov/pubmed/29587786)
BACKGROUND: The influenza A virus non-structural protein 1 (NS1) is a multifunctional protein that plays an important role in virus replication, virulence and inhibition of the host antiviral immune response. ... Huang CG, Lee LA, Wu YC, Hsiao MJ. A pilot study on primary cultures of human respiratory tract epithelial cells to predict patients´ responses to H7N9 infection. Oncotarget. 2018 Feb 20;9(18):14492-14508. Abstract
submitted by kickingbird at Apr, 2, 2018 from Oncotarget. 2018 Feb 20;9(18):14492-14508 (via https://www.ncbi.nlm.nih.gov/pubmed/29581859)
Avian influenza A(H7N9) virus infections frequently lead to acute respiratory distress syndrome and death in humans. We aimed to investigate whether primary cultures of human respiratory tract epithelial ... Oh KH, Mo JS, Bae YJ, Lee SB, Lai VD, Wang SJ. Amino acid substitutions in low pathogenic avian influenza virus strains isolated from wild birds in Korea. Virus Genes. 2018 Mar 26. Abstract
submitted by kickingbird at Apr, 2, 2018 from Virus Genes. 2018 Mar 26 (via https://www.ncbi.nlm.nih.gov/pubmed/29582231)
Wild birds are natural hosts and reservoirs for influenza A viruses. However, many species, such as many waterfowl, are asymptomatic when infected and so facilitate the generation of viral genetic diversity. ... Manoj Kumar,etc.,al. Emergence of novel reassortant H6N2 avian influenza viruses in ducks in India. Infect Genet Evol Volume 61, July 2018. Abstract
submitted by kickingbird at Mar, 29, 2018 from Infect Genet Evol Volume 61, July 2018 (via https://www.sciencedirect.com/science/article/pii/S156713481)
The recent reports of human infection due to H6 subtype avian influenza viruses (AIV), which are prevalent in terrestrial poultry, indicate evolution of the virus to a possible pandemic strain. Here, we ... Xian Qi, Xiaofei An, etc.,al. Co-circulation of multiple genotypes of influenza A (H7N9) viruses in eastern China, 2016-2017. Arch Virol 14 March 2018. Abstract
submitted by kickingbird at Mar, 29, 2018 from Arch Virol 14 March 2018 (via https://link.springer.com/article/10.1007/s00705-018-3800-3)
Five epidemic waves of human infection with influenza A (H7N9) virus have emerged in China since spring 2013. We previously described the epidemiological characterization of the fifth wave in Jiangsu province. ... In-Won Lee,etc.,al. Comparison of the virulence and transmissibility of canine H3N2 influenza viruses and characterization of their canine adaptation factors. Emerging Microbes & Infections vol 7,2018. Abstract
submitted by kickingbird at Mar, 29, 2018 from Emerging Microbes & Infections vol 7,2018 (via https://www.nature.com/articles/s41426-017-0013-x)
Recent canine influenza outbreaks have raised concerns about the generation of pathogenic variants that may pose a threat to public health. Here, we examine avian-like H3N2 canine influenza viruses (CIVs) ... McKimm-Breschkin JL, Barrett S, Wong FYK. Identification of Indonesian clade 2.1 highly pathogenic influenza A(H5N1) viruses with N294S and S246N neuraminidase substitutions which further reduce oseltamivir susceptibility. Antiviral Res. 2018 Mar 21. Abstract
submitted by kickingbird at Mar, 29, 2018 from Antiviral Res. 2018 Mar 21 (via https://www.sciencedirect.com/science/article/pii/S016635421)
We have tested the in vitro susceptibility to the neuraminidase (NA) inhibitors of 96 highly pathogenic clade 2.1 A(H5N1) viruses from Indonesia, isolated between 2008 and 2011. HPAI virus samples obtained ... Yang W, Cummings MJ, Bakamutumaho B. Dynamics of Influenza in Tropical Africa: Temperature, Humidity, and Co-circulating (sub)types. Influenza Other Respir Viruses. 2018 Mar 23.. Abstract
submitted by kickingbird at Mar, 29, 2018 from Influenza Other Respir Viruses. 2018 Mar 23. (via https://www.ncbi.nlm.nih.gov/pubmed/29573157)
BACKGROUND: The association of influenza with meteorological variables in tropical climates remains controversial. Here we investigate the impact of weather conditions on influenza in the tropics and factors ... Moore J, Ahmed H, Antia R. High dimensional random walks can appear low dimensional: application to influenza H3N2 evolution. J Theor Biol. 2018 Mar 20. Abstract
submitted by kickingbird at Mar, 29, 2018 from J Theor Biol. 2018 Mar 20 (via https://www.ncbi.nlm.nih.gov/pubmed/29571708)
One important feature of the mammalian immune system is the highly specific binding of antigens to antibodies. Antibodies generated in response to one infection may also provide some level of cross immunity ... 5584 items, 20/Page, Page[165/280][|<<] [|<] [161] [162] [163] [164] [165] [166] [167] [168] [169] [170] [>|] [>>|] |
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