Dustin M. McCraw, John R. Gallagher, Udana Torian,. Structural analysis of influenza vaccine virus-like particles reveals a multicomponent organization. Scientific Reports volume 8, Article number: 1034. Abstract
submitted by kickingbird at Jul, 28, 2018 from Scientific Reports volume 8, Article number: 1034 (via https://www.nature.com/articles/s41598-018-28700-7)
Influenza virus continues to be a major health problem due to the continually changing immunodominant head regions of the major surface glycoprotein, hemagglutinin (HA). However, some emerging vaccine ... Wang Z, etc.,al. Detailed mapping of the linear B Cell epitopes of the hemagglutinin (HA) protein of swine influenza virus. Virology. 2018 Jul 17;522:131-137.. Abstract
submitted by kickingbird at Jul, 26, 2018 from Virology. 2018 Jul 17;522:131-137. (via https://www.ncbi.nlm.nih.gov/pubmed/30029012)
Using the Hemagglutinin (HA) protein peptide array of H1N1 pdm09 and a panel of swine antisera against various swine influenza H1 and H3 clusters, we identified three immunoreactive epitopes with one (peptide ... Peng C, etc.,al. Molecular epidemiological survey and complete genomic phylogenetic analysis of H6 subtype avian influenza viruses in poultry in China from 2011 to 2016. Infect Genet Evol. 2018 Jul 19.. Abstract
submitted by kickingbird at Jul, 26, 2018 from Infect Genet Evol. 2018 Jul 19. (via https://www.ncbi.nlm.nih.gov/pubmed/30031927)
To investigate the prevalence and evolution of the H6 subtype avian influenza viruses (AIVs) circulating in poultry in China from 2011 to 2016, 11 molecular epidemiological surveys was performed in this ... Grund C, etc.,al. A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential. Emerg Microbes Infect. 2018 Jul 19;7(1):132. Abstract
submitted by kickingbird at Jul, 26, 2018 from Emerg Microbes Infect. 2018 Jul 19;7(1):132 (via https://www.ncbi.nlm.nih.gov/pubmed/30026505)
We investigated in a unique setup of animal models and a human lung explant culture biological properties, including zoonotic potential, of a representative 2016 highly pathogenic avian influenza virus ... Fujikura D, Miyazaki T.. Programmed Cell Death in the Pathogenesis of Influenza. Int J Mol Sci. 2018 Jul 16;19(7). Abstract
submitted by kickingbird at Jul, 23, 2018 from Int J Mol Sci. 2018 Jul 16;19(7) (via https://www.ncbi.nlm.nih.gov/pubmed/30012970)
Influenza is a respiratory disease induced by infection by the influenza virus, which is a member of Orthomyxoviridae family. This infectious disease has serious impacts on public health systems and results ... Root JJ， etc.,al. Viral shedding of clade 2.3.4.4 H5 highly pathogenic avian influenza A viruses by American robins. Transbound Emerg Dis. 2018 Jul 17.. Abstract
submitted by kickingbird at Jul, 23, 2018 from Transbound Emerg Dis. 2018 Jul 17. (via https://www.ncbi.nlm.nih.gov/pubmed/30014592)
American robins (Turdus migratorius) are commonly associated with farmsteads in the United States and have shown previous evidence of exposure to an H5 avian influenza A virus (IAV) near a poultry production ... Gambaryan AS, Matrosovich TY, Boravleva EY, Lomaki. Receptor-binding properties of influenza viruses isolated from gulls. Virology 2018;522:37-45. Abstract
submitted by kickingbird at Jul, 23, 2018 from Virology 2018;522:37-45 (via https://www.ncbi.nlm.nih.gov/m/pubmed/30014856/)
Ducks, gulls and shorebirds represent the major hosts of influenza A viruses (IAVs) in nature, but distinctions of IAVs in different birds are not well defined. Here we characterized the receptor specificity ... Hatta Y, Boltz D, Sarawar S, Kawaoka Y, et al. Novel influenza vaccine M2SR protects against drifted H1N1 and H3N2 influenza virus challenge in ferrets with pre-existing immunity. Vaccine 2018 Jul 12.. Abstract
submitted by kickingbird at Jul, 23, 2018 from Vaccine 2018 Jul 12. (via https://www.ncbi.nlm.nih.gov/m/pubmed/30007825/)
Current influenza vaccines do not provide effective protection against heterologous influenza viruses. The ability of the novel M2SR influenza vaccine to protect against drifted influenza viruses was evaluated ... Lin X, Noel JK, Wang Q, Ma J, et al. Atomistic simulations indicate the functional loop-to-coiled-coil transition in influenza hemagglutinin is not downhill. Proc Natl Acad Sci U S A 2018 Jul 16.. Abstract
submitted by kickingbird at Jul, 23, 2018 from Proc Natl Acad Sci U S A 2018 Jul 16. (via https://www.ncbi.nlm.nih.gov/m/pubmed/30012616/)
Influenza hemagglutinin (HA) mediates viral entry into host cells through a large-scale conformational rearrangement at low pH that leads to fusion of the viral and endosomal membranes. Crystallographic ... Nogales A, Martinez-Sobrido L, Chiem K, Topham DJ,. FUNCTIONAL EVOLUTION OF THE 2009 PANDEMIC H1N1 INFLUENZA NS1 AND PA IN HUMANS. J Virol 2018 Jul 18. Abstract
submitted by kickingbird at Jul, 23, 2018 from J Virol 2018 Jul 18 (via https://www.ncbi.nlm.nih.gov/m/pubmed/30021892/)
In 2009, an H1N1 influenza A virus (IAV, pH1N1) emerged in the human population from swine causing a pandemic. Importantly, this virus is still circulating in humans seasonally. To analyze the evolution ... Huang QS, Bandaranayake D, Wood T, Newbern EC, et. Risk factors and attack rates of seasonal influenza infection: results of the SHIVERS seroepidemiologic cohort study. J Infect Dis 2018 Jul 17. Abstract
submitted by kickingbird at Jul, 23, 2018 from J Infect Dis 2018 Jul 17 (via https://www.ncbi.nlm.nih.gov/m/pubmed/30016464/)
Background: Understanding the attack rate of influenza infection and the proportion who become ill by risk group is key to implementing prevention measures. While population-based studies of anti-haemagglutinin ... Hickman HD, Mays JW, Gibbs J, Kosik I, et al. Influenza A Virus Negative Strand RNA Is Translated for CD8+ T Cell Immunosurveillance. Immunol 2018 Jul 16.. Abstract
submitted by kickingbird at Jul, 23, 2018 from Immunol 2018 Jul 16. (via https://www.ncbi.nlm.nih.gov/m/pubmed/30012850/)
Probing the limits of CD8+ T cell immunosurveillance, we inserted the SIINFEKL peptide into influenza A virus (IAV)-negative strand gene segments. Although IAV genomic RNA is considered noncoding, there ... Furuyama Y, Takahashi Y, Noguchi K, Murakami H, et. Subpopulation Primers Essential for Exhaustive Detection of Diverse Hemagglutinin Genes of H5-Subtype Avian Influenza Viruses by Loop-mediated Isothermal Amplification Method. J Clin Microbiol 2018 Jul 18. Abstract
submitted by kickingbird at Jul, 23, 2018 from J Clin Microbiol 2018 Jul 18 (via https://www.ncbi.nlm.nih.gov/m/pubmed/30021821/)
Loop-mediated isothermal amplification (LAMP) is a potential screening test for avian influenza (AI), but its narrow detection spectrum hinders the field of applications. To improve this narrow detection ... Sant S, etc.,al. Single-Cell Approach to Influenza-Specific CD8+ T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection. Front Immunol. 2018 Jun 27;9:1453. Abstract
submitted by kickingbird at Jul, 16, 2018 from Front Immunol. 2018 Jun 27;9:1453 (via https://www.ncbi.nlm.nih.gov/pubmed/29997621)
CD8+ T cells recognizing antigenic peptides derived from conserved internal viral proteins confer broad protection against distinct influenza viruses. As memory CD8+ T cells change throughout the human ... Ng YP, Yip TF, Peiris JSM, Ip NY, Lee SMY. Avian influenza A H7N9 virus infects human astrocytes and neuronal cells and induces inflammatory immune responses. J Neurovirol. 2018 Jul 9. Abstract
submitted by kickingbird at Jul, 16, 2018 from J Neurovirol. 2018 Jul 9 (via https://www.ncbi.nlm.nih.gov/pubmed/29987581)
Seasonal, pandemic, and avian influenza virus infections may be associated with central nervous system pathology, albeit with varying frequency and different mechanisms. Here, we demonstrate that differentiated ... Schr?der T. etc.,al. The clinically approved MEK inhibitor Trametinib efficiently blocks influenza A virus propagation and cytokine expression. Antiviral Res. 2018 Jul 7;157:80-92. Abstract
submitted by kickingbird at Jul, 16, 2018 from Antiviral Res. 2018 Jul 7;157:80-92 (via https://www.ncbi.nlm.nih.gov/pubmed/29990517)
Influenza A virus (IAV) infections are still a major global threat for humans, especially for the risk groups of young children and the elderly. Annual epidemics and sporadically occurring pandemics highlight ... Bangaru S, etc.,al. A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA. Nat Commun. 2018 Jul 10;9(1):2669. Abstract
submitted by kickingbird at Jul, 16, 2018 from Nat Commun. 2018 Jul 10;9(1):2669 (via https://www.ncbi.nlm.nih.gov/pubmed/29991715)
The high rate of antigenic drift in seasonal influenza viruses necessitates frequent changes in vaccine composition. Recent seasonal H3 vaccines do not protect against swine-origin H3N2 variant (H3N2v) ... Gao Z, etc.,al. The PA-interacting host protein nucleolin acts as an antiviral factor during highly pathogenic H5N1 avian influenza virus infection. Arch Virol. 2018 Jul 5. Abstract
submitted by kickingbird at Jul, 9, 2018 from Arch Virol. 2018 Jul 5 (via https://www.ncbi.nlm.nih.gov/pubmed/29974255)
Polymerase acidic (PA) protein is a multifunctional regulator of influenza A virus (IAV) replication and pathogenesis. In a previous study, we reported that nucleolin (NCL) is a novel PA-interacting host ... Keating R, Morris MY, etc.,al. Potential killers exposed: tracking endogenous influenza-specific CD8+ T cells. Immunol Cell Biol. 2018 Jul 4.. Abstract
submitted by kickingbird at Jul, 9, 2018 from Immunol Cell Biol. 2018 Jul 4. (via https://www.ncbi.nlm.nih.gov/pubmed/29972699)
Current influenza A virus (IAV) vaccines stimulate antibody responses that are directed against variable regions of the virus, and are therefore ineffective against divergent strains. As CD8+ T cells target ... Hu J, Ma C, Liu X. PA-X: a key regulator of influenza A virus pathogenicity and host immune responses. Med Microbiol Immunol. 2018 Jul 4.. Abstract
submitted by kickingbird at Jul, 9, 2018 from Med Microbiol Immunol. 2018 Jul 4. (via https://www.ncbi.nlm.nih.gov/pubmed/29974232)
PA-X, a fusion protein belonging to influenza A viruses (IAVs), integrating the N-terminal 191 amino acids of PA gene and the ribosomal frame-shifting product that lengthens out to 41 or 61 amino acids. ... 5584 items, 20/Page, Page[158/280][|<<] [|<] [151] [152] [153] [154] [155] [156] [157] [158] [159] [160] [>|] [>>|] |
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