Lapuente D, Ruzsics Z, Thirion C, Tenbusch M, et a. Evaluation of adenovirus 19a as a novel vector for mucosal vaccination against influenza A viruses. Lapuente D, Ruzsics Z, Thirion C, Tenbusch M, et a. Abstract
submitted by kickingbird at Apr, 16, 2018 from Lapuente D, Ruzsics Z, Thirion C, Tenbusch M, et a (via https://www.ncbi.nlm.nih.gov/m/pubmed/29628150/)
Since preexisting immunity and enhanced infection rates in a clinical trial of an HIV vaccine have raised some concerns on adenovirus (Ad) serotype 5-based vaccines, we evaluated the subgroup D adenovirus ... Bae JY, Lee I, Kim JI, Park S, et al. A Single Amino Acid at the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses. J Virol 2018 Apr 11. Abstract
submitted by kickingbird at Apr, 16, 2018 from J Virol 2018 Apr 11 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29643248/)
Influenza B virus (IBV) is one of the human respiratory viruses and the targets of seasonal vaccination. However, the bifurcation of two antigenically distinct lineages of IBVs makes it difficult to arrange ... Wang Y, Guo Q, Yan Z, Zhou D, et al. Factors Associated With Prolonged Viral Shedding in Patients With Avian Influenza A(H7N9) Virus Infection. J Infect Dis 2018 Apr 10. Abstract
submitted by kickingbird at Apr, 16, 2018 from J Infect Dis 2018 Apr 10 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29648602/)
Background: Data are limited on the impact of neuraminidase inhibitor (NAI) treatment on avian influenza A(H7N9) virus RNA shedding. Methods: In this multicenter, retrospective study, data were collected ... Zhu H, Lee ACY, Li C, Mak WWN, Chen YY, etc.,al. Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017. Emerg Microbes Infect. 2018 Mar 6;7(1):23. Abstract
submitted by kickingbird at Apr, 9, 2018 from Emerg Microbes Infect. 2018 Mar 6;7(1):23 (via https://www.ncbi.nlm.nih.gov/pubmed/29511175)
The 2017 Hong Kong influenza A(H3N2) summer season was unexpectedly severe. However, antigenic characterization of the 2017 circulating A(H3N2) viruses using ferret antisera did not show significant antigenic ... Liping Ma, etc.,al. Two reassortant types of highly pathogenic H5N8 avian influenza virus from wild birds in Central China in 2016. Emerging Microbes & Infections (2018) 7:14. Abstract
submitted by kickingbird at Apr, 9, 2018 from Emerging Microbes & Infections (2018) 7:14 (via https://www.ncbi.nlm.nih.gov/pubmed/29410395)
Since 2016, the highly pathogenic avian influenza H5N8 virus has emerged in the Central Asian flyway and Europe, causing massive deaths in poultry and wild birds. In this study, we isolated and identified ... Reeves AB, Hall JS, Poulson RL, etc.,al. Influenza A virus recovery, diversity, and intercontinental exchange: A multi-year assessment of wild bird sampling at Izembek National Wildlife Refuge, Alaska. PLoS One. 2018 Apr 5;13(4):e0195327. Abstract
submitted by kickingbird at Apr, 8, 2018 from PLoS One. 2018 Apr 5;13(4):e0195327 (via https://www.ncbi.nlm.nih.gov/pubmed/29621333)
Western Alaska is a potential point-of-entry for foreign-origin influenza A viruses (IAVs) into North America via migratory birds. We sampled waterfowl and gulls for IAVs at Izembek National Wildlife Refuge ... Wu XX, Deng XL, Yu DS, etc.,al. The Protective Effects of the A/ZJU01/ PR8/2013 Split H7N9 Avian Influenza Vaccine Against Highly Pathogenic H7N9 in BALB/c Mice. Cell Physiol Biochem. 2018 Mar 28. Abstract
submitted by kickingbird at Apr, 8, 2018 from Cell Physiol Biochem. 2018 Mar 28 (via https://www.ncbi.nlm.nih.gov/pubmed/29617693)
BACKGROUND/AIMS: Since the first case of novel H7N9 infection was reported, China has experienced five epidemics of H7N9. During the fifth wave, a highly pathogenic H7N9 strain emerged. In order to assess ... Gao R, Gu M, Liu K, Li Q, Li J, Shi L, etc.,al. T160A mutation-induced deglycosylation at site 158 in hemagglutinin is a critical determinant of the dual receptor binding properties of clade 2.3.4.4 H5NX subtype avian influenza viruses. Vet Microbiol. 2018 Apr;217:158-166. Abstract
submitted by kickingbird at Apr, 8, 2018 from Vet Microbiol. 2018 Apr;217:158-166 (via https://www.ncbi.nlm.nih.gov/pubmed/29615249)
Most clade 2.3.4.4 H5NX subtype avian influenza viruses possess a T160A amino acid substitution in the hemagglutinin (HA) protein that has been shown to affect the receptor binding properties of a clade ... Kadam RU, Wilson IA. A small-molecule fragment that emulates binding of receptor and broadly neutralizing antibodies to influenza A hemagglutinin. PNAS. 2018 Apr 2. Abstract
submitted by kickingbird at Apr, 8, 2018 from PNAS. 2018 Apr 2 (via https://www.ncbi.nlm.nih.gov/pubmed/29610325)
The influenza virus hemagglutinin (HA) glycoprotein mediates receptor binding and membrane fusion during viral entry in host cells. Blocking these key steps in viral infection has applications for development ... Yao-Qing Chen, etc.,al. Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies. Cell Vol 173, Issue 2, p417–429.e10, 5 April 2018. Abstract
submitted by kickingbird at Apr, 6, 2018 from Cell Vol 173, Issue 2, p417–429.e10, 5 April 2018 (via http://www.cell.com/cell/fulltext/S0092-8674(18)30310-6)
Antibodies to the hemagglutinin (HA) and neuraminidase (NA) glycoproteins are the major mediators of protection against influenza virus infection. Here, we report that current influenza vaccines poorly ... Melissa A Rolfes, etc.,al. Influenza-Associated Parotitis During the 2014~2015 Influenza Season in the United States. Clinical Infectious Diseases 30 Mar 2018. Abstract
submitted by kickingbird at Apr, 6, 2018 from Clinical Infectious Diseases 30 Mar 2018 (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
BackgroundDuring the 2014–2015 influenza season in the United States, 256 cases of influenza-associated parotitis were reported from 27 states. We conducted a case-control study and laboratory investigation ... Masato Hatta, Gongxun Zhong, Yuwei Gao,etc.,al. Characterization of a Feline Influenza A(H7N2) Virus. EID Vol 24, Number 1,Jan 2018. Abstract
submitted by kickingbird at Apr, 4, 2018 from EID Vol 24, Number 1,Jan 2018 (via https://wwwnc.cdc.gov/eid/article/24/1/17-1240_article)
During December 2016–February 2017, influenza A viruses of the H7N2 subtype infected ≈500 cats in animal shelters in New York, NY, USA, indicating virus transmission among cats. A veterinarian who treated ... Isakova-Sivak I, Korenkov D, Smolonogina T, Kotomi. Broadly protective anti-hemagglutinin stalk antibodies induced by live attenuated influenza vaccine expressing chimeric hemagglutinin. Virology 2018;518:313-323. Abstract
submitted by kickingbird at Apr, 3, 2018 from Virology 2018;518:313-323 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29574336/)
The development of influenza vaccines that can provide broad protection against all drifted seasonal virus variants, zoonotic infections and emerging pandemic strains, has been a priority for two decades. ... van de Sandt CE, Pronk MR, van Baalen CA, Fouchier. Variation at extra-epitopic amino acid residues influences suppression of influenza virus replication by M158-66 epitope-specific CD8+ T lymphocytes. J Virol 2018 Mar 28. Abstract
submitted by kickingbird at Apr, 3, 2018 from J Virol 2018 Mar 28 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29593036/)
Influenza virus-specific CD8+ T lymphocytes (CTL) contribute to clearance of influenza virus infections and reduce disease severity. Variation at amino acid residues located in- or outside CTL epitopes ... Wang W, Song HS, Keller PW, Alvarado-Facundo E, et. Conformational stability of the hemagglutinin of H5N1 influenza A viruses influences susceptibility to broadly neutralizing stem antibodies. J Virol 2018 Mar 28. Abstract
submitted by kickingbird at Apr, 3, 2018 from J Virol 2018 Mar 28 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29593038/)
Vaccines that elicit broadly neutralizing antibodies to the conserved stem of hemagglutinin (HA) are being developed as universal influenza vaccines that protect against influenza across multiple years. ... Wen L, Chu H, Wong BH, Wang D, Li C. Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses. Emerg Microbes Infect. 2018 Mar 29;7(1):47. Abstract
submitted by kickingbird at Apr, 2, 2018 from Emerg Microbes Infect. 2018 Mar 29;7(1):47 (via https://www.ncbi.nlm.nih.gov/pubmed/29593225)
To elucidate the adaptive strategies of influenza A viruses (IAVs) to human, we proposed a computational approach to identify human-adaptive mutations in seasonal IAVs, which have not been analyzed comprehensively. ... Peng X, Liu F, Wu H, Peng X, Xu Y, Wang L. Amino Acid Substitutions HA A150V, PA A343T, and PB2 E627K Increase the Virulence of H5N6 Influenza Virus in Mice. Front Microbiol. 2018 Mar 13;9:453. Abstract
submitted by kickingbird at Apr, 2, 2018 from Front Microbiol. 2018 Mar 13;9:453 (via https://www.ncbi.nlm.nih.gov/pubmed/29593694)
H5N6 avian influenza viruses (AIVs) can cause severe pneumonia and death in humans. However, the molecular determinants of H5N6 influenza virus mammalian adaption are still unclear. Three amino acid substitutions ... Takemae N, Tsunekuni R, Uchida Y, Ito T, Saito T. Experimental infection of pigs with H1 and H3 influenza A viruses of swine by using intranasal nebulization. BMC Vet Res. 2018 Mar 27;14(1):115. Abstract
submitted by kickingbird at Apr, 2, 2018 from BMC Vet Res. 2018 Mar 27;14(1):115 (via https://www.ncbi.nlm.nih.gov/pubmed/29587842)
BACKGROUND: Experimental infection of pigs via direct intranasal or intratracheal inoculation has been mainly used to study the infectious process of influenza A viruses of swine (IAVs-S). Nebulization ... Trapp S, Soubieux D, etc.,al. Major contribution of the RNA-binding domain of NS1 in the pathogenicity and replication potential of an avian H7N1 influenza virus in chickens. Virol J. 2018 Mar 27;15(1):55. Abstract
submitted by kickingbird at Apr, 2, 2018 from Virol J. 2018 Mar 27;15(1):55 (via https://www.ncbi.nlm.nih.gov/pubmed/29587792)
BACKGROUND: Non-structural protein NS1 of influenza A viruses harbours several determinants of pathogenicity and host-range. However it is still unclear to what extent each of its two structured domains ... Cheng J, Zhang C, Tao J, Li B, Shi Y, Liu H. Effects of the S42 residue of the H1N1 swine influenza virus NS1 protein on interferon responses and virus replication. Virol J. 2018 Mar 27;15(1):57. Abstract
submitted by kickingbird at Apr, 2, 2018 from Virol J. 2018 Mar 27;15(1):57 (via https://www.ncbi.nlm.nih.gov/pubmed/29587786)
BACKGROUND: The influenza A virus non-structural protein 1 (NS1) is a multifunctional protein that plays an important role in virus replication, virulence and inhibition of the host antiviral immune response. ... 5153 items, 20/Page, Page[143/258][|<<] [|<] [141] [142] [143] [144] [145] [146] [147] [148] [149] [150] [>|] [>>|] |
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