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2024-4-20 19:11:06
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Chong CR, et al. Safety of Inactivated Influenza Vaccine in Cancer Patients Receiving Immune Checkpoint Inhibitors (ICI). Clin Infect Dis. 2019 Mar 15..  Abstract  
submitted by kickingbird at Mar, 17, 2019 from Clin Infect Dis. 2019 Mar 15. (via https://academic.oup.com/cid/advance-article-abstract/doi/10)
BACKGROUND: Cancer patients are at a higher risk for developing influenza (flu) related complications. It is unclear if the flu vaccine exacerbates immune events in patients treated with ICIs.METHODS: ...

Takizawa N, et al. Local structural changes of the influenza A virus ribonucleoprotein complex by single mutations in the specific residues involved in efficient genome packaging. Virology. 2019 Mar 7;531:126-140.  Abstract  
submitted by kickingbird at Mar, 17, 2019 from Virology. 2019 Mar 7;531:126-140 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
The influenza A virus genome consists of eight single-stranded negative-sense RNA segments. The noncoding regions located at the 3'- and 5'- ends of each segment are necessary for genome packaging, and ...

Zhou AC, Batista NV, Watts TH. 4-1BB Regulates Effector CD8 T Cell Accumulation in the Lung Tissue through a TRAF1-, mTOR-, and Antigen-Dependent Mechanism to Enhance Tissue-Resident Memory T Cell Formation during Respiratory Influ. J Immunol. 2019 Mar 13..  Abstract  
submitted by kickingbird at Mar, 16, 2019 from J Immunol. 2019 Mar 13. (via http://www.jimmunol.org/content/early/2019/03/13/jimmunol.18)
The TNFR superfamily member 4-1BB is important in the establishment of tissue-resident memory T cells (Trm) in the lung tissue following influenza infection. Moreover, supraphysiological boosting of 4-1BB ...

Siegers JY, et al. Viral Factors Important for Efficient Replication of Influenza A Viruses in Cells of the Central Nervous System. J Virol. 2019 Mar 13..  Abstract  
submitted by kickingbird at Mar, 15, 2019 from J Virol. 2019 Mar 13. (via https://jvi.asm.org/content/early/2019/03/07/JVI.02273-18)
Central nervous system (CNS) disease is one of the most common extra-respiratory tract complication of influenza A virus infections. Remarkably, zoonotic H5N1 virus infections are more frequently associated ...

Alnaji FG, et al. Sequencing framework for the sensitive detection and precise mapping of defective interfering particle-associated deletions across influenza A and B viruses. J Virol. 2019 Mar 13..  Abstract  
submitted by kickingbird at Mar, 15, 2019 from J Virol. 2019 Mar 13. (via https://jvi.asm.org/content/early/2019/03/07/JVI.00354-19)
The mechanisms and consequences of defective interfering particle (DIP) formation during influenza virus infection remain poorly understood. The development of next generation sequencing (NGS) technologies ...

Lai JCC, et al. Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding. Emerg Microbes Infect. 2019;8(1):327-338.  Abstract  
submitted by kickingbird at Mar, 15, 2019 from Emerg Microbes Infect. 2019;8(1):327-338 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Influenza virus haemagglutinin (HA) and neuraminidase (NA) are involved in the recognition and modulation of sialic acids on the cell surface as the virus receptor. Although the balance between two proteins ...

Welkers MRA, et al. Genetic diversity and host adaptation of avian H5N1 influenza viruses during human infection. Emerg Microbes Infect. 2019;8(1):262-271..  Abstract  
submitted by kickingbird at Mar, 15, 2019 from Emerg Microbes Infect. 2019;8(1):262-271. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
The continuing pandemic threat posed by avian influenza A/H5N1 viruses calls for improved insights into their evolution during human infection. We performed whole genome deep sequencing of respiratory ...

Monamele CG, et al. Evidence of exposure and human seroconversion during an outbreak of avian influenza A(H5N1) among poultry in Cameroon. Emerg Microbes Infect. 2019;8(1):186-196.  Abstract  
submitted by kickingbird at Mar, 15, 2019 from Emerg Microbes Infect. 2019;8(1):186-196 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1)
From May 2016 to March 2017, 22 poultry outbreaks of avian influenza A(H5N1) were reported in Cameroon, mainly in poultry farms and live bird markets. No human cases were reported. In this study, we sought ...

Pan M, Yang HP, Jian J, et al. Association of meteorological factors with seasonal activity of influenza A subtypes and B lineages in subtropical western China. Epidemiol Infect. 2019 Jan;147:e72.  Abstract  
submitted by kickingbird at Mar, 15, 2019 from Epidemiol Infect. 2019 Jan;147:e72 (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
The seasonality of individual influenza subtypes/lineages and the association of influenza epidemics with meteorological factors in the tropics/subtropics have not been well understood. The impact of the ...

Amanat F, Meade P, Strohmeier S, Krammer F. Cross-reactive antibodies binding to H4 hemagglutinin protect against a lethal H4N6 influenza virus challenge in the mouse model. Emerg Microbes Infect. 2019;8(1):155-168.  Abstract  
submitted by kickingbird at Mar, 15, 2019 from Emerg Microbes Infect. 2019;8(1):155-168 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1)
Influenza viruses of the H4 subtype are widespread in wild birds, circulate in domestic poultry, readily infect mammals, and tolerate the insertion of a polybasic cleavage site. In addition, serological ...

Bao L, et al. Diverse biological characteristics and varied virulence of H7N9 from Wave 5. Emerg Microbes Infect. 2019;8(1):94-102..  Abstract  
submitted by kickingbird at Mar, 15, 2019 from Emerg Microbes Infect. 2019;8(1):94-102. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1)
There was a substantial increase with infections of H7N9 avian influenza virus (AIV) in humans during Wave 5 (2016-2017). To investigate whether H7N9 had become more infectious/transmissible and pathogenic ...

Yao Y, et al. Protection against homo and hetero-subtypic in?uenza A virus by optimized M2e DNA vaccine. Emerg Microbes Infect. 2019;8(1):45-54.  Abstract  
submitted by kickingbird at Mar, 15, 2019 from Emerg Microbes Infect. 2019;8(1):45-54 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1)
Current influenza vaccines provide hemagglutinin strain-specific protection, but rarely provide cross-protection against divergent strains. It is, therefore, particularly important to develop a universal ...

Njifon HLM, et al. Genetic diversity of influenza A(H3N2) viruses in Northern Cameroon during the 2014-2016 influenza seasons. J Med Virol. 2019 Mar 13.  Abstract  
submitted by kickingbird at Mar, 15, 2019 from J Med Virol. 2019 Mar 13 (via https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25456)
In Cameroon, genome characterization of influenza virus has been performed only in the Southern regions meanwhile genetic diversity of this virus varies with respect to locality. The Northern region characterized ...

Quan L, Ji C, Ding X, Peng Y, Liu M, Sun J, et al. Cluster-transition determining sites underlying the antigenic evolution of seasonal influenza viruses. Mol Biol Evol. 2019 Mar 9.  Abstract  
submitted by kickingbird at Mar, 14, 2019 from Mol Biol Evol. 2019 Mar 9 (via https://academic.oup.com/mbe/advance-article-abstract/doi/10)
Seasonal influenza viruses undergo frequent mutations on their surface hemagglutinin (HA) proteins to escape the host immune response. In these mutations, a few key amino acid sites are associated with ...

Karunakaran AC, et al. Survivability of Highly Pathogenic Avian Influenza Virus (H5N1) in naturally preened Duck Feathers at different temperatures. Transbound Emerg Dis. 2019 Mar 12..  Abstract  
submitted by kickingbird at Mar, 13, 2019 from Transbound Emerg Dis. 2019 Mar 12. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13148)
Ducks are the "Trojan Horses" for Asian H5N1 avian influenza viruses (AIV) and attain carrier status without displaying overt infection. These birds help in the spread of the virus among the poultry and ...

Cueno ME, et al. Structural significance of residues 158-160 in the H3N2 hemagglutnin globular head: A computational study with implications in viral evolution and infection. J Mol Graph Model. 2019 Feb 25;89:33-40..  Abstract  
submitted by kickingbird at Mar, 10, 2019 from J Mol Graph Model. 2019 Feb 25;89:33-40. (via https://www.sciencedirect.com/science/article/pii/S109332631)
Influenza A H3N2 has been linked to annual outbreaks within the human population attributable to continuous structural changes. H3N2 HA contains well identified antigenic sites and receptor-binding sites ...

Liu J, Zhou L, Lv J, Zou Y, Wang T. Two novel reassortant H11N8 avian influenza viruses occur in wild birds found in East Dongting Lake, China. Arch Virol. 2019 Mar 8.  Abstract  
submitted by kickingbird at Mar, 10, 2019 from Arch Virol. 2019 Mar 8 (via https://link.springer.com/article/10.1007%2Fs00705-019-04168)
During the surveillance of avian influenza viruses in East Dongting Lake, China (2014-2015), two H11N8 avian influenza viruses were detected in the bean goose (Anser fabalis) and the falcated teal (Anas ...

Michalak P, et al. Secondary structure of the segment 5 genomic RNA of influenza A virus and its application for designing antisense oligonucleotides. Sci Rep. 2019 Mar 7;9(1):3801.  Abstract  
submitted by kickingbird at Mar, 10, 2019 from Sci Rep. 2019 Mar 7;9(1):3801 (via https://www.nature.com/articles/s41598-019-40443-7)
Influenza virus causes seasonal epidemics and dangerous pandemic outbreaks. It is a single stranded (-)RNA virus with a segmented genome. Eight segments of genomic viral RNA (vRNA) form the virion, which ...

van Dongen MJP, et al. A small-molecule fusion inhibitor of influenza virus is orally active in mice. Science. 2019 Mar 8;363(6431)..  Abstract  
submitted by kickingbird at Mar, 10, 2019 from Science. 2019 Mar 8;363(6431). (via http://science.sciencemag.org/content/363/6431/eaar6221)
Recent characterization of broadly neutralizing antibodies (bnAbs) against influenza virus identified the conserved hemagglutinin (HA) stem as a target for development of universal vaccines and therapeutics. ...

Jacqueline M. Nolting Scott D. Scheer Andrew S.. Perceptions and attitudes of swine exhibitors towards recommendations for reducing zoonotic transmission of influenza A viruses. Zoonoses and Public Health 06 Mar 2019.  Abstract  
submitted by kickingbird at Mar, 10, 2019 from Zoonoses and Public Health 06 Mar 2019 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/zph.12574)
Since 2011, there have been 468 cases of variant influenza A virus (IAV) reported in the United States, many of which were associated with youth swine exhibition. In an effort to mitigate risk associated ...

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