Kim JI, et al. Novel small molecule targeting the hemagglutinin stalk of influenza viruses. J Virol. 2019 Jun 5.. Abstract
submitted by kickingbird at Jun, 9, 2019 from J Virol. 2019 Jun 5. (via https://jvi.asm.org/content/early/2019/05/30/JVI.00878-19)
Combating influenza is one of the perennial global public health issues to be managed. Antiviral drugs are useful for the treatment of influenza in the absence of an appropriate vaccine. However, the appearance ... Nooruzzaman M, et al. A new reassortant clade 2.3.2.1a H5N1 highly pathogenic avian influenza virus causing recent outbreaks in ducks, geese, chickens and turkeys in Bangladesh. Transbound Emerg Dis. 2019 Jun 6.. Abstract
submitted by kickingbird at Jun, 9, 2019 from Transbound Emerg Dis. 2019 Jun 6. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13264)
A total of 15 dead or sick birds from 13 clinical outbreaks of avian influenza in ducks, geese, chickens and turkeys in 2017 in Bangladesh were examined. The presence of H5N1 influenza A virus in the affected ... Zhong W, Levine MZ. Stockpiled avian influenza A(H7N9) vaccines induce robust, non-neutralizing functional antibodies against antigenically drifted 5th wave A(H7N9) viruses. J Infect Dis. 2019 Jun 5.. Abstract
submitted by kickingbird at Jun, 9, 2019 from J Infect Dis. 2019 Jun 5. (via https://academic.oup.com/jid/advance-article/doi/10.1093/inf)
Human infections caused by avian influenza A(H7N9) viruses have raised concerns of a pandemic. The capability of the current stockpiled A(H7N9) vaccines to induce cross-protective, non-neutralizing functional ... Yu Z, Cheng K, Wang T, Ren Z, Wu J, He H, Gao Y. Two mutations in viral protein enhance the adaptation of waterfowl-origin H3N2 virus in murine model. Virus Res. 2019 Jun 4. pii: S0168-1702(19)30049-8. Abstract
submitted by kickingbird at Jun, 9, 2019 from Virus Res. 2019 Jun 4. pii: S0168-1702(19)30049-8 (via https://www.sciencedirect.com/science/article/abs/pii/S01681)
After serial passage of a waterfowl-origin H3N2 subtype avian influenza virus in BALB/c mice, we obtained H3N2 mouse-adapted variants and identified eight amino acid substitutions in five viral proteins ... Huang SY, et al. Novel Role for miR-1290 in Host Species Specificity of Influenza A Virus. Mol Ther Nucleic Acids. 2019 May 15;17:10-23.. Abstract
submitted by kickingbird at Jun, 9, 2019 from Mol Ther Nucleic Acids. 2019 May 15;17:10-23. (via https://www.cell.com/molecular-therapy-family/nucleic-acids/)
The role of microRNA (miRNA) in influenza A virus (IAV) host species specificity is not well understood as yet. Here, we show that a host miRNA, miR-1290, is induced through the extracellular signal-regulated ... Meng W, et al. New evidence for the east-west spread of the highly pathogenic avian influenza H5N1 virus between Central Asian and east Asian-Australasian flyways in China. Emerg Microbes Infect. 2019;8(1):823-826.. Abstract
submitted by kickingbird at Jun, 6, 2019 from Emerg Microbes Infect. 2019;8(1):823-826. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
The spread of highly pathogenic avian influenza (HPAI) H5N1 virus is associated with wild fowl migration in East Asian-Australasian (EA) and Central Asian (CA) flyways. However, the spread of H5N1 virus ... Lee ACY, et al. H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses. Cell Death Dis. 2019 Jun 5;10(6):442. Abstract
submitted by kickingbird at Jun, 6, 2019 from Cell Death Dis. 2019 Jun 5;10(6):442 (via https://www.nature.com/articles/s41419-019-1684-0)
We previously demonstrated that avian influenza A H7N9 virus preferentially infected CD14+ monocyte in human peripheral blood mononuclear cells (PBMCs), which led to apoptosis. To better understand H7N9 ... Choi WS, et al. Development of a rapid, simple and efficient one-pot cloning method for a reverse genetics system of broad subtypes of influenza A virus. Sci Rep. 2019 Jun 5;9(1):8318. Abstract
submitted by kickingbird at Jun, 6, 2019 from Sci Rep. 2019 Jun 5;9(1):8318 (via https://www.nature.com/articles/s41598-019-44813-z)
The reverse genetics (RG) system of influenza A viruses is well established. However, the conventional sequence-dependent method for cloning influenza genome segments is time-consuming and requires multiple ... Scharenberg M, et al. Influenza A Virus Infection Induces Hyperresponsiveness in Human Lung Tissue-Resident and Peripheral Blood NK Cells. Front Immunol. 2019 May 17;10:1116. Abstract
submitted by kickingbird at Jun, 5, 2019 from Front Immunol. 2019 May 17;10:1116 (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0111)
NK cells in the human lung respond to influenza A virus- (IAV-) infected target cells. However, the detailed functional capacity of human lung and peripheral blood NK cells remains to be determined in ... Rowe HM, et al. Direct interactions with influenza promote bacterial adherence during respiratory infections. Nat Microbiol. 2019 May 20.. Abstract
submitted by kickingbird at Jun, 5, 2019 from Nat Microbiol. 2019 May 20. (via https://www.nature.com/articles/s41564-019-0447-0)
Epidemiological observations and animal models have long shown synergy between influenza virus infections and bacterial infections. Influenza virus infection leads to an increase in both the susceptibility ... Gong S, et al. Human-Derived A/Guangdong/Th005/2017 (H7N9) Exhibits Extremely High Replication in the Lungs of Ferrets and Is Highly Pathogenic in Chickens. Viruses. 2019 May 29;11(6. Abstract
submitted by kickingbird at Jun, 3, 2019 from Viruses. 2019 May 29;11(6 (via https://www.mdpi.com/1999-4915/11/6/494)
After a series of studies on the pathogenicity of several H7N9 strains from 2013 to 2018, we wanted to dynamically track the pathogenicity of A/Guangdong/Th005/2017 in ferrets and poultry. The pathogenicity ... Antigua KJC, Choi WS, Baek YH, Song MS. The Emergence and Decennary Distribution of Clade 2.3.4.4 HPAI H5Nx. Microorganisms. 2019 May 29;7(6).. Abstract
submitted by kickingbird at Jun, 3, 2019 from Microorganisms. 2019 May 29;7(6). (via https://www.mdpi.com/2076-2607/7/6/156)
Reassortment events among influenza viruses occur naturally and may lead to the development of new and different subtypes which often ignite the possibility of an influenza outbreak. Between 2008 and 2010, ... Levy ER, et al. Evaluation of Mannose Binding Lectin Gene Variants in Pediatric Influenza Virus-Related Critical Illness. Front Immunol. 2019 May 8;10:1005.. Abstract
submitted by kickingbird at May, 31, 2019 from Front Immunol. 2019 May 8;10:1005. (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0100)
Background: Mannose-binding lectin (MBL) is an innate immune protein with strong biologic plausibility for protecting against influenza virus-related sepsis and bacterial co-infection. In an autopsy cohort ... Du R, Cui Q, Rong L. Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry. Viruses. 2019 May 20;11(5).. Abstract
submitted by kickingbird at May, 31, 2019 from Viruses. 2019 May 20;11(5). (via https://www.mdpi.com/1999-4915/11/5/458)
The hemagglutinin (HA) and neuraminidase (NA) of influenza A virus possess antagonistic activities on interaction with sialic acid (SA), which is the receptor for virus attachment. HA binds SA through ... Wu et al.. Preventing an Antigenically Disruptive Mutation in Egg-Based H3N2 Seasonal Influenza Vaccines by Mutational Incompatibility. Cell Host & Microbe. Abstract
submitted by kickingbird at May, 29, 2019 from Cell Host & Microbe (via https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(1)
Egg-based seasonal influenza vaccines are the major preventive countermeasure against influenza virus. However, their effectiveness can be compromised when antigenic changes arise from egg-adaptive mutations ... Nelson SA, Sant AJ. Imprinting and Editing of the Human CD4 T Cell Response to Influenza Virus. Front Immunol. 2019 May 7;10:932.. Abstract
submitted by kickingbird at May, 29, 2019 from Front Immunol. 2019 May 7;10:932. (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0093)
Immunity to influenza is unique among pathogens, in that immune memory is established both via intermittent lung localized infections with highly variable influenza virus strains and by intramuscular vaccinations ... Farrukee R, Butler J, Reading PC, Hurt AC. Characterization of substitutions in the neuraminidase of A(H7N9) influenza viruses selected following serial passage in the presence of different neuraminidase inhibitors. Antiviral Res. 2019 May 24.. Abstract
submitted by kickingbird at May, 29, 2019 from Antiviral Res. 2019 May 24. (via https://www.sciencedirect.com/science/article/pii/S016635421)
Avian A(H7N9) infections in humans have been reported in China since 2013 and are of public health concern due to their severity and pandemic potential. Oseltamivir and peramivir are neuraminidase inhibitors ... Spackman E, et al. Assessment of replicate numbers for titrating avian influenza virus using dose-response models. J Vet Diagn Invest. 2019 May 25:1040638719853851.. Abstract
submitted by kickingbird at May, 29, 2019 from J Vet Diagn Invest. 2019 May 25:1040638719853851. (via https://www.ncbi.nlm.nih.gov/pubmed/31131714)
Embryonating chicken eggs (ECEs) are among the most sensitive laboratory host systems for avian influenza virus (AIV) titration, but ECEs are expensive and require space for storage and incubation. Therefore, ... Guinat C, Rouchy N, Camy F, Guérin JL, Paul MC. Exploring the Wind-Borne Spread of Highly Pathogenic Avian Influenza H5N8 During the 2016-2017 Epizootic in France. Avian Dis. 2018 Oct 11;63. Abstract
submitted by kickingbird at May, 29, 2019 from Avian Dis. 2018 Oct 11;63 (via https://bioone.org/journals/Avian-Diseases/volume-63/issue-s)
In winter 2016-2017, highly pathogenic avian influenza (HPAI) H5N8 virus spread in France, causing an unprecedented epizootic. During the epidemic, southwest France, where most outbreaks were reported, ... Pénzes Z, et al. Rapid Construction and Immunogenicity Testing of a Novel H5 Virus-Like Particle Prototype Vaccine Against Clade 2.3.4.4 H5N8 Highly Pathogenic Avian Influenza Virus. Avian Dis. 2018 Dec 18;63. Abstract
submitted by kickingbird at May, 29, 2019 from Avian Dis. 2018 Dec 18;63 (via https://bioone.org/journals/Avian-Diseases/volume-63/issue-s)
From October 2016 to July 2017, 47 countries have been affected by highly pathogenic avian influenza (HPAI) viruses of the H5N8 clade 2.3.4.4 subtype, including European and African, and it has been the ... 5170 items, 20/Page, Page[101/259][|<<] [|<] [101] [102] [103] [104] [105] [106] [107] [108] [109] [110] [>|] [>>|] |
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