Krammer F, et al. Meeting report and review: Immunological assays and correlates of protection for next-generation influenza vaccines. Influenza Other Respir Viruses. 2019 Dec 13.. Abstract
submitted by kickingbird at Dec, 16, 2019 from Influenza Other Respir Viruses. 2019 Dec 13. (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12706)
BACKGROUND: This report summarizes the discussions and conclusions from the "Immunological Assays and Correlates of Protection for Next-Generation Influenza Vaccines" meeting which took place in Siena, ...
Zhou Y, Li S, Bi S, Li N, Bi Y, Liu W, Wang B. Long-lasting protective immunity against H7N9 infection is induced by intramuscular or CpG-adjuvanted intranasal immunization with the split H7N9 vaccine. Int Immunopharmacol. 2019 Dec 2:106013.. Abstract
submitted by kickingbird at Dec, 8, 2019 from Int Immunopharmacol. 2019 Dec 2:106013. (via https://www.sciencedirect.com/science/article/pii/S156757691)
There is an urgent need for efficient vaccines against the highly pathogenic avian influenza A viral strain H7N9. The duration and intensity of the immune response to H7N9 critically impacts the epidemiology ...
Wang S, et al. Reverse transcription recombinase-aided amplification assay for H7 subtype avian influenza virus. Transbound Emerg Dis. 2019 Nov 12.. Abstract
submitted by kickingbird at Nov, 14, 2019 from Transbound Emerg Dis. 2019 Nov 12. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13411)
H7 subtype avian influenza virus infection is an emerging zoonosis in some Asian countries and an important avian disease worldwide. A rapid and simple test is needed to confirm infection in suspected ...
Hirotsu N, et al. Baloxavir marboxil in Japanese pediatric patients with influenza: safety and clinical and virologic outcomes. Clin Infect Dis. 2019 Sep 20.. Abstract
submitted by kickingbird at Sep, 22, 2019 from Clin Infect Dis. 2019 Sep 20. (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
BACKGROUND: We assessed the safety and effectiveness of baloxavir marboxil administration in Japanese children with influenza.METHODS: This open-label study administered one weigth-adjusted dose of baloxavir ...
Nakamura K, et al. Systematic evaluation of suspension MDCK cells, adherent MDCK cells, and LLC-MK2 cells for preparing influenza vaccine seed virus. Vaccine. 2019 Sep 6.. Abstract
submitted by kickingbird at Sep, 12, 2019 from Vaccine. 2019 Sep 6. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Suspension Madin-Darby canine kidney (MDCK) cells (MDCK-N), adherent MDCK cells (MDCK-C), and adherent rhesus monkey kidney LLC-MK2 cells (LLC-MK2D) were systematically evaluated for the preparation of ...
Coronel J, et al. Influenza A virus production in a single-use orbital shaken bioreactor with ATF or TFF perfusion systems. Vaccine. 2019 Jun 29. pii: S0264-410X(19)30764-9.. Abstract
submitted by kickingbird at Jul, 7, 2019 from Vaccine. 2019 Jun 29. pii: S0264-410X(19)30764-9. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Driven by the concept of plug-and-play cell culture-based viral vaccine production using disposable bioreactors, we evaluated an orbital shaken bioreactor (OSB) for human influenza A virus production at ...
Zhao ZX, Cheng LP, Li M, Pang W, Wu FH. Discovery of novel acylhydrazone neuraminidase inhibitors. Eur J Med Chem. 2019 Apr 5;173:305-313. Abstract
submitted by kickingbird at Apr, 27, 2019 from Eur J Med Chem. 2019 Apr 5;173:305-313 (via https://www.sciencedirect.com/science/article/pii/S022352341)
Neuraminidase (NA) plays a crucial role in the replication and transmission of influenza virus. NA inhibitors have been developed as effective treatments for influenza A and B infections. In this paper, ...
Sawlwin DC, Graves Jones A, Albano FR. Modification of the vaccine manufacturing process improves the pyrogenicity profile of inactivated influenza vaccines in young children. Vaccine. 2019 Mar 29. pii: S0264-410X(19)30390-1.. Abstract
submitted by kickingbird at Apr, 4, 2019 from Vaccine. 2019 Mar 29. pii: S0264-410X(19)30390-1. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
BACKGROUND: There were increased reports of fevers and febrile reactions in young children (particularly children aged METHODS: For each study, fever rates (any grade and severe) were determined for the ...
Ross TM, et al. A computationally designed H5 antigen shows immunological breadth of coverage and protects against drifting avian strains. Vaccine. 2019 Mar 21.. Abstract
submitted by kickingbird at Mar, 26, 2019 from Vaccine. 2019 Mar 21. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Since the first identification of the H5N1 Goose/Guangdong lineage in 1996, this highly pathogenic avian influenza virus has spread worldwide, becoming endemic in domestic poultry. Sporadic transmission ...
Lindert K, Leav B, Heijnen E, Barrett J, Nicolay U. MF59-Adjuvanted Seasonal Trivalent Influenza Vaccine: Pooled Analysis of Safety in Older Adults ≥65 Years of Age. Int J Infect Dis. 2019 Mar 20.. Abstract
submitted by kickingbird at Mar, 26, 2019 from Int J Infect Dis. 2019 Mar 20. (via https://www.ijidonline.com/article/S1201-9712(19)30149-3/pdf)
OBJECTIVE: To assess the long-term safety of MF59-adjuvanted trivalent influenza vaccine (aIIV3; Fluad?) in adults ≥65 years of age.METHODS: Data from 36 primary vaccination and 7 re-vaccination Phase ...
Puchades C, et al. Epitope mapping of diverse influenza Hemagglutinin drug candidates using HDX-MS. Sci Rep. 2019 Mar 18;9(1):4735. Abstract
submitted by kickingbird at Mar, 25, 2019 from Sci Rep. 2019 Mar 18;9(1):4735 (via https://www.nature.com/articles/s41598-019-41179-0)
Epitope characterization is critical for elucidating the mechanism of action of drug candidates. However, traditional high-resolution epitope mapping techniques are not well suited for screening numerous ...
Nogales A, et al. A novel fluorescent and bioluminescent Bi-Reporter influenza A virus (BIRFLU) to evaluate viral infections. J Virol. 2019 Mar 13. Abstract
submitted by kickingbird at Mar, 15, 2019 from J Virol. 2019 Mar 13 (via https://jvi.asm.org/content/early/2019/03/07/JVI.00032-19)
Studying influenza A virus (IAV) requires the use of secondary approaches to detect the presence of virus in infected cells. To overcome this problem, we and others have generated recombinant IAV expressing ...
Ting-Hui-Lin, et al. Improving immunogenicity of influenza virus H7N9 recombinant hemagglutinin for vaccine development. Vaccine. 2019 Mar 22;37(13):1897-1903.. Abstract
submitted by kickingbird at Mar, 13, 2019 from Vaccine. 2019 Mar 22;37(13):1897-1903. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Human infections of novel avian influenza A virus (H7N9) emerged in early 2013 and caused about 40% case-fatality through 2017. Therefore, development of influenza H7N9 vaccines is critical for pandemic ...
Pramuwidyatama MG, et al. A Systematic Evaluation of Measures Against Highly Pathogenic Avian Influenza (HPAI) in Indonesia. Front Vet Sci. 2019 Feb 18;6:33.. Abstract
submitted by kickingbird at Mar, 7, 2019 from Front Vet Sci. 2019 Feb 18;6:33. (via https://www.frontiersin.org/articles/10.3389/fvets.2019.0003)
Over the past years, many different control measures have been implemented to prevent HPAI infection. The national plan with numerous measures lead to problems in terms of prioritization and budget allocation. ...
Barnes B, et al. Modelling high pathogenic avian influenza outbreaks in the commercial poultry industry. Theor Popul Biol. 2019 Feb 27.. Abstract
submitted by kickingbird at Mar, 3, 2019 from Theor Popul Biol. 2019 Feb 27. (via https://www.sciencedirect.com/science/article/pii/S004058091)
Highly pathogenic avian influenza (HPAI) outbreaks are devastating to poultry industries and pose a risk to human health. There is concern that demand for free-range poultry products could increase the ...
Hasan M, et al. Reverse vaccinology approach to design a novel multi-epitope subunit vaccine against avian influenza A (H7N9) virus. Microb Pathog. 2019 Feb 26. Abstract
submitted by kickingbird at Mar, 3, 2019 from Microb Pathog. 2019 Feb 26 (via https://www.sciencedirect.com/science/article/pii/S088240101)
H7N9, a novel strain of avian origin influenza was the first recorded incidence where a human was transited by a N9 type influenza virus. Effective vaccination against influenza A (H7N9) is a major concern, ...
Wang Z, et al. Enhanced cross-lineage protection induced by recombinant H9N2 avian influenza virus inactivated vaccine. Vaccine. 2019 Feb 20.. Abstract
submitted by kickingbird at Feb, 25, 2019 from Vaccine. 2019 Feb 20. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
BACKGROUND: Antigenic drift of H9N2 low pathogenic avian influenza viruses (AIV) may result in vaccination failure in the poultry industry and thus a cross-protective vaccine against H9N2 AIV is highly ...
Gerlach T, Elbahesh H, Saletti G, Rimmelzwaan G. Recombinant influenza A viruses as vaccine vectors. Expert Rev Vaccines. 2019 Feb 19.. Abstract
submitted by kickingbird at Feb, 21, 2019 from Expert Rev Vaccines. 2019 Feb 19. (via https://www.ncbi.nlm.nih.gov/pubmed/30777467)
Various viruses, including poxviruses, adenoviruses and vesicular stomatitis virus, have been considered as vaccine vectors for the delivery of antigens of interest in the development of vaccines against ...
Hu Y, et al. Immunogenicity and safety of a trivalent inactivated influenza vaccine produced in Shenzhen, China versus a comparator influenza vaccine: a phase IV randomized study. Hum Vaccin Immunother. 2019 Feb 19. Abstract
submitted by kickingbird at Feb, 21, 2019 from Hum Vaccin Immunother. 2019 Feb 19 (via https://www.ncbi.nlm.nih.gov/pubmed/30779689)
Seasonal influenza causes substantial morbidity and mortality in China, which largely results from limited vaccine accessibility and poor vaccination coverage. Since 2013, Sanofi Pasteur's facilities in ...
Byrne-Nash RT, et al. A neuraminidase potency assay for quantitative assessment of neuraminidase in influenza vaccines. NPJ Vaccines. 2019 Jan 22;4:3. Abstract
submitted by kickingbird at Jan, 26, 2019 from NPJ Vaccines. 2019 Jan 22;4:3 (via https://www.ncbi.nlm.nih.gov/pubmed/30675394)
Neuraminidase (NA) immunity leads to decreased viral shedding and reduced severity of influenza disease; however, NA content in influenza vaccines is currently not regulated, resulting in inconsistent ...
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