Hussain S, et al. Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine viruses. J Virol. 2018 Oct 31.. Abstract
submitted by kickingbird at Nov, 3, 2018 from J Virol. 2018 Oct 31. (via https://www.ncbi.nlm.nih.gov/pubmed/30381488)
The PA-X protein of influenza A virus has roles in host cell shut-off and viral pathogenesis. While most strains are predicted to encode PA-X, strain-dependent variations in activity have been noted. We ...
van der Lubbe JEM, et al. Mini-HA Is Superior to Full Length Hemagglutinin Immunization in Inducing Stem-Specific Antibodies and Protection Against Group 1 Influenza Virus Challenges in Mice. Front Immunol. 2018 Oct 12;9:2350. Abstract
submitted by kickingbird at Oct, 31, 2018 from Front Immunol. 2018 Oct 12;9:2350 (via https://www.frontiersin.org/articles/10.3389/fimmu.2018.0235)
Seasonal influenza vaccines are updated almost annually to match the antigenic drift in influenza hemagglutinin (HA) surface glycoprotein. A new HA stem-based antigen, the so-called "mini-HA," was recently ...
St Charles KM, et al. Avian Influenza in the U.S. Commercial Upland Game Bird Industry: An Analysis of Selected Practices as Potential Exposure Pathways and Surveillance System Data Reporting. Avian Dis. 2018 Sep;62(3):307-315.. Abstract
submitted by kickingbird at Oct, 21, 2018 from Avian Dis. 2018 Sep;62(3):307-315. (via https://www.ncbi.nlm.nih.gov/pubmed/30339513)
Producing a smaller yield of higher-value birds compared to conventional poultry production, the U.S. commercial upland game bird industry deals primarily in the sale of live birds for recreational hunting. ...
Claeys C, et al. Anamnestic Immune Response and Safety of an Inactivated Quadrivalent Influenza Vaccine in Primed Versus Vaccine-Na?ve Children. Pediatr Infect Dis J. 2018 Oct 15.. Abstract
submitted by kickingbird at Oct, 18, 2018 from Pediatr Infect Dis J. 2018 Oct 15. (via https://www.ncbi.nlm.nih.gov/pubmed/30325891)
BACKGROUND: It has not yet been demonstrated whether two doses of inactivated quadrivalent influenza vaccine (IIV4) prime a booster response in infants. We evaluated the anamnestic immune response to an ...
Loebermann M, et al. A phase III, open-label, single-arm, study to evaluate the safety and immunogenicity of a trivalent, surface antigen inactivated subunit influenza virus vaccine produced in mammalian cell culture (Opt. Infection. 2018 Oct 8.. Abstract
submitted by kickingbird at Oct, 15, 2018 from Infection. 2018 Oct 8. (via https://www.ncbi.nlm.nih.gov/pubmed/30298473)
Vaccination is an essential tool in reducing the impact of seasonal influenza infections. The viral strains responsible for seasonal outbreaks vary annually, and preventive vaccines have to be adapted ...
Nelson SW, etc.,al. Evaluation of nonwoven fabrics for nasal wipe sampling for influenza A virus in swine. J Vet Diagn Invest. 2018 Sep 28:1040638718803999. Abstract
submitted by kickingbird at Oct, 3, 2018 from J Vet Diagn Invest. 2018 Sep 28:1040638718803999 (via https://www.ncbi.nlm.nih.gov/pubmed/30264670)
Influenza A virus (IAV) is a zoonotic pathogen threatening animal and public health; therefore, detection and monitoring of IAV in animal populations are critical components of a surveillance program. ...
Klepser ME, Adams AJ. Pharmacy-based management of influenza: lessons learned from research. Int J Pharm Pract. 2018 Sep 28.. Abstract
submitted by kickingbird at Oct, 3, 2018 from Int J Pharm Pract. 2018 Sep 28. (via https://www.ncbi.nlm.nih.gov/pubmed/30265414)
Recently, several jurisdictions have pursued legislative and regulatory changes to allow pharmacy-based influenza management models in which pharmacists can initiate appropriate antiviral therapy in community ...
Scott LJ. Peramivir: A Review in Uncomplicated Influenza. Drugs. 2018 Sep 8.. Abstract
submitted by kickingbird at Sep, 13, 2018 from Drugs. 2018 Sep 8. (via https://www.ncbi.nlm.nih.gov/pubmed/30196350)
Intravenous peramivir (Alpivab?; Rapivab?; Rapiacta?; PeramiFlu?), the most recent globally approved inhibitor of influenza neuraminidase, is indicated for the treatment of uncomplicated influenza in adults ...
Wang C, Zhou J, Zhang C, Liu Z, Liu Y, Cai K. Adjuvant Activity of Bursal Pentapeptide-(III-V) in Mice Immunized with the H9N2 Avian Influenza Vaccine. Protein Pept Lett. 2018 Aug 5. Abstract
submitted by kickingbird at Aug, 11, 2018 from Protein Pept Lett. 2018 Aug 5 (via https://www.ncbi.nlm.nih.gov/pubmed/30081784)
Bursal pentapeptide (BPP)-(III-V) are peptides isolated from the bursa of Fabricius (BF). The peptides' adjuvant activities were evaluated in mice immunized with the H9N2 avian influenza vaccine. The results ...
MEDINA J, Guillot V, Totain E, Rouleau M, et al. Vero/CHOK1, a novel mixture of cell lines that is optimal for the rescue of influenza A vaccine seeds. J Virol Methods. 2013 Oct 23. Abstract
submitted by kickingbird at Nov, 4, 2013 from J Virol Methods. 2013 Oct 23 (via http://www.ncbi.nlm.nih.gov/pubmed/24161812)
Seasonal and pandemic influenza vaccine manufacturing is challenged with a tight production schedule. Reverse genetics constitutes a rapid method for creating viruses. Vero and CHOK1 cells were found to ...
Lenzer J. Belief not science is behind flu jab promotion, new report says. BMJ 2012;345:e7856. Abstract
submitted by kickingbird at Feb, 3, 2013 from BMJ 2012;345:e7856 (via http://www.bmj.com/content/345/bmj.e7856?view=long&pmid=2316)
An independent meta-analysis of vaccines against influenza has found that claims of benefit have been significantly exaggerated.
The report, released last month by the University of Minnesota’s Center ...
WER. Antigenic and genetic characteristics of zoonotic influenza viruses and development of candidate vaccine viruses for pandemic preparedness. WHO. Abstract
submitted by kickingbird at Oct, 22, 2011 from WHO (via http://www.who.int/wer/2011/wer8643/en/index.html)
Antigenic and genetic characteristics of zoonotic influenza viruses and development of candidate vaccine viruses for pandemic preparedness Standardization of terminology of the pandemic A(H1N1) 2009 ...
BARRETT PN, Berezuk G, Fritsch S, Aichinger G, et. Efficacy, safety, and immunogenicity of a Vero-cell-culture-derived trivalent influenza vaccine: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet. 2011 Feb 26;377(9767):751-9. Epub 2011 Feb. Abstract
submitted by kickingbird at Mar, 4, 2011 from Lancet. 2011 Feb 26;377(9767):751-9. Epub 2011 Feb (via http://www.ncbi.nlm.nih.gov/pubmed/21329971)
BACKGROUND: The use of cell-culture technologies for the manufacture of influenza vaccines might contribute to improved strain selection and robust vaccine supplies. We investigated the safety, immunogenicity, ...
Lisa Wilson. International Swine Flu Conference in Washington, DC on August 19-21, 2009. New-Fileds. Abstract
submitted by lisa_wilson at Jun, 3, 2009 from New-Fileds (via http://new-fields.com/ISFC)
Delegates are coming from US, Europe, Africa and Asia Pacific.In addition to insightful presentations and dynamic panel discussions, you can also choose from over 30 concurrent breakout sessions that includes:Breakout ...
Mahmood K, Bright RA, Mytle N, Carter DM, Crevar C. H5N1 VLP vaccine induced protection in ferrets against lethal challenge with highly pathogenic H5N1 influenza viruses. Vaccine. 2008 Aug 13. Abstract
submitted by kickingbird at Aug, 27, 2008 from Vaccine. 2008 Aug 13 (via http://www.ncbi.nlm.nih.gov/pubmed/18706956)
In this study, recombinant virus-like particles (VLPs) were evaluated as a candidate vaccine against emerging influenza viruses with pandemic potential. The VLPs are composed of the hemagglutinin (HA), ...
Song L, Nakaar V, Kavita U, Price A, Huleatt J, Ta. Efficacious recombinant influenza vaccines produced by high yield bacterial expression: a solution to global pandemic and seasonal needs. PLoS ONE. 2008 May 21;3(5):e2257. Abstract
submitted by kickingbird at May, 27, 2008 from PLoS ONE. 2008 May 21;3(5):e2257 (via http://www.plosone.org/article/info:doi/10.1371/journal.pone)
It is known that physical linkage of TLR ligands and vaccine antigens significantly enhances the immunopotency of the linked antigens. We have used this approach to generate novel influenza vaccines that ...
Cruz AT, Cazacu AC, Greer JM, Demmler GJ.. Rapid assays for the diagnosis of influenza A and B viruses in patients evaluated at a large tertiary care children´s hospital during two consecutive winter seasons. J Clin Virol. 2007 Dec 14. Abstract
submitted by kickingbird at Dec, 18, 2007 from J Clin Virol. 2007 Dec 14 (via http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=ShowD)
BACKGROUND: The rapid and accurate diagnosis of influenza facilitates antiviral therapy, judicious antibiotic usage, and cohorting patients to decrease nosocomial infection. OBJECTIVE: To determine the ...
Vesikari T, Karvonen A, Korhonen T, Edelman K, Vai. A Randomized, Double-Blind Study of the Safety, Transmissibility and Phenotypic and Genotypic Stability of Cold-Adapted Influenza Virus Vaccine. Pediatr Infect Dis J. 2006 Jul;25(7):590-595. Abstract
submitted by wanglh at Jun, 30, 2006 from Pediatr Infect Dis J. 2006 Jul;25(7):590-595 (via http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d)
BACKGROUND:: Live attenuated influenza vaccine (LAIV; FluMist) is a trivalent vaccine containing cold-adapted influenza vaccine viruses that infect and replicate in cells lining the nasopharynx to induce ...
Zhang H, Su YA, Hu P, Yang J, Zheng B, Wu P, Peng. Signature patterns revealed by microarray analyses of mice infected with influenza virus A and Streptococcus pneumoniae. Microbes Infect. 2006 Jun 2; [Epub ahead of print]. Abstract
submitted by wanglh at Jun, 30, 2006 from Microbes Infect. 2006 Jun 2; [Epub ahead of print] (via http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d)
We used cDNA microarrays to identify differentially expressed genes in mice in response to infections with influenza virus A/PR/8/34 (H1N1) and Streptococcus pneumoniae. Expression microarray analysis ...
Lee VJ, Phua KH, Chen MI, Chow A, Ma S, Goh KT, and Leo YS. Economics of Neuraminidase Inhibitor Stockpiling for Pandemic Influenza, Singapore. Emerg Infect Dis . 2006 Jan edition. Full Text
submitted by kickingbird at Dec, 6, 2005 from Emerg Infect Dis . 2006 Jan edition (via http://www.cdc.gov/ncidod/EID/vol12no01/05-0556.htm)
We compared strategies for stockpiling neuraminidase inhibitors to treat and prevent influenza in Singapore. Cost-benefit and cost-effectiveness analyses, with Monte Carlo simulations, were used to determine ...
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