Mori K, Ohniwa RL, Takizawa N, Naito T, Saito M. Development of a Genetically Stable Live Attenuated Influenza Vaccine Strain using an Engineered High-Fidelity Viral Polymerase. J Virol. 2021 Apr 7:JVI.00493-21. Abstract
submitted by kickingbird at Apr, 9, 2021 from J Virol. 2021 Apr 7:JVI.00493-21 (via https://jvi.asm.org/content/early/2021/04/02/JVI.00493-21)
RNA viruses demonstrate a vast range of variants, called quasispecies, due to error-prone replication by viral RNA-dependent RNA polymerase. Although live attenuated vaccines are effective in preventing ...
Liu Y, Zhan L, Wang Y, Kangas J, Larkin D, Boulwar. Improved Influenza Diagnostics through Thermal Contrast Amplification. Diagnostics (Basel). 2021 Mar 7;11(3):462. Abstract
submitted by kickingbird at Apr, 4, 2021 from Diagnostics (Basel). 2021 Mar 7;11(3):462 (via https://www.mdpi.com/2075-4418/11/3/462)
Influenza poses a serious health threat and creates an economic burden for people around the world. The accurate diagnosis of influenza is critical to the timely clinical treatment of patients and the ...
Nagashima KA, Mousa JJ. Next-Generation Influenza HA Immunogens and Adjuvants in Pursuit of a Broadly Protective Vaccine. Viruses. 2021 Mar 24;13(4):546. Abstract
submitted by kickingbird at Apr, 4, 2021 from Viruses. 2021 Mar 24;13(4):546 (via https://www.mdpi.com/1999-4915/13/4/546)
Influenza virus, a highly mutable respiratory pathogen, causes significant disease nearly every year. Current vaccines are designed to protect against circulating influenza strains of a given season. However, ...
Tasker S, Wight O´Rourke A, Suyundikov A, Ja. Safety and Immunogenicity of a Novel Intranasal Influenza Vaccine (NasoVAX): A Phase 2 Randomized, Controlled Trial. Vaccines (Basel). 2021 Mar 5;9(3):224. Abstract
submitted by kickingbird at Apr, 4, 2021 from Vaccines (Basel). 2021 Mar 5;9(3):224 (via https://www.mdpi.com/2076-393X/9/3/224)
Annual influenza vaccination greatly reduces morbidity and mortality, but effectiveness remains sub-optimal. Weaknesses of current vaccines include low effectiveness against mismatched strains, lack of ...
Dilai M, Fassi Fihri O, El Harrak M, Bouchiba A, D. An Evaluation of Three Different Primary Equine Influenza Vaccination Intervals in Foals. J Equine Vet Sci. 2021 Apr;99:103397. Abstract
submitted by kickingbird at Mar, 31, 2021 from J Equine Vet Sci. 2021 Apr;99:103397 (via https://www.sciencedirect.com/science/article/abs/pii/S07370)
In order to evaluate the effect of three different primary vaccination intervals on EI vaccine response, 21 unvaccinated thoroughbred foals were randomly divided into three groups of 7 and vaccinated with ...
Boyoglu-Barnum S, Ellis D, Gillespie RA, Hutchinso. Quadrivalent influenza nanoparticle vaccines induce broad protection. Nature. 2021 Mar 24. Abstract
submitted by kickingbird at Mar, 26, 2021 from Nature. 2021 Mar 24 (via https://www.nature.com/articles/s41586-021-03365-x)
Influenza vaccines that confer broad and durable protection against diverse viral strains would have a major effect on global health, as they would lessen the need for annual vaccine reformulation and ...
Tang H, Shen C, Zou L, Cai C, Edwards J, Bruce M,. Value chain analysis of yellow broiler industry in Guangxi, China to inform H7N9 influenza control strategies. Prev Vet Med. 2021 Mar 17;190:105328. Abstract
submitted by kickingbird at Mar, 26, 2021 from Prev Vet Med. 2021 Mar 17;190:105328 (via https://www.sciencedirect.com/science/article/abs/pii/S01675)
Yellow broilers are the primary source of poultry consumption in China and the predominant trade of live poultry. However, knowledge of the value chain is limited, which is vital evidence for the effective ...
Landgraf G, Desheva YA, Rudenko LG. Evaluation of influenza A and B cold-adapted reassortant virus reproduction in trivalent live influenza vaccines. Virus Res. 2021 Mar 17:198396. Abstract
submitted by kickingbird at Mar, 22, 2021 from Virus Res. 2021 Mar 17:198396 (via https://www.sciencedirect.com/science/article/abs/pii/S01681)
Background: The objective of the present study was to compare reproduction of trivalent LAIV vaccine strains in MDCK cells and to perform quantitative RT-PCR analysis of trivalent LAIV replication after ...
Stadlbauer D, Waal L, Beaulieu E, Strohmeier S, Kr. AS03-adjuvanted H7N9 inactivated split virion vaccines induce cross-reactive and protective responses in ferrets. NPJ Vaccines. 2021 Mar 19;6(1):40. Abstract
submitted by kickingbird at Mar, 22, 2021 from NPJ Vaccines. 2021 Mar 19;6(1):40 (via https://www.nature.com/articles/s41541-021-00299-3)
Human infections with avian H7N9 subtype influenza viruses are a major public health concern and vaccines against H7N9 are urgently needed for pandemic preparedness. In early 2013, novel H7N9 influenza ...
Trexler M, Brusatori M, Auner G. Avidin-biotin complex-based capture coating platform for universal Influenza virus immobilization and characterization. PLoS One. 2021 Feb 26;16(2):e0247429. Abstract
submitted by kickingbird at Feb, 27, 2021 from PLoS One. 2021 Feb 26;16(2):e0247429 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Influenza virus mutates quickly and unpredictably creating emerging pathogenic strains that are difficult to detect, diagnose, and characterize. Conventional tools to study and characterize virus, such ...
Chang LJ, Anderson EJ, Jeanfreau R, He Y, Hicks B,. Safety and immunogenicity of high doses of quadrivalent influenza vaccine in children 6 months through <18 years of age: A randomized controlled phase II dose-finding trial. Vaccine. 2021 Feb 18:S0264-410X(21)00162-6. Abstract
submitted by kickingbird at Feb, 22, 2021 from Vaccine. 2021 Feb 18:S0264-410X(21)00162-6 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Quadrivalent high-dose inactivated influenza vaccine (Fluzone? High-Dose Quadrivalent, IIV4-HD) was licensed in the USA in 2019 for adults ≥ 65 years of age. This Phase II study examined safety and immunogenicity ...
Sch?n J, Ran W, Gorka M, Schwemmle M, Beer M, Hoff. A modified live bat influenza A virus-based vaccine prototype provides full protection against HPAIV H5N1. NPJ Vaccines. 2020 May 15;5(1):40. Abstract
submitted by kickingbird at Feb, 14, 2021 from NPJ Vaccines. 2020 May 15;5(1):40 (via https://www.nature.com/articles/s41541-020-0185-6)
Highly pathogenic avian influenza viruses (HPAIVs) of subtype H5 are a major threat for poultry holdings worldwide, here especially the zoonotic Asian H5N1 viruses. These HPAIVs have caused more than 500 ...
Pleguezuelos O, James E, Fernandez A, Lopes V, Ros. Efficacy of FLU-v, a broad-spectrum influenza vaccine, in a randomized phase IIb human influenza challenge study. NPJ Vaccines. 2020 Mar 13;5(1):22. Abstract
submitted by kickingbird at Feb, 14, 2021 from NPJ Vaccines. 2020 Mar 13;5(1):22
FLU-v, developed by PepTcell (SEEK), is a peptide vaccine aiming to provide a broadly protective cellular immune response against influenza A and B. A randomized, double-blind, placebo-controlled, single-center, ...
de Jonge J, van Dijken H, de Heij F, Spijkers S, M. H7N9 influenza split vaccine with SWE oil-in-water adjuvant greatly enhances cross-reactive humoral immunity and protection against severe pneumonia in ferrets. NPJ Vaccines. 2020 May 11;5(1):38.. Abstract
submitted by kickingbird at Feb, 14, 2021 from NPJ Vaccines. 2020 May 11;5(1):38. (via https://www.nature.com/articles/s41541-020-0187-4)
Until universal influenza vaccines become available, pandemic preparedness should include developing classical vaccines against potential pandemic influenza subtypes. We here show that addition of SWE ...
Sharma S, Kumari V, Kumbhar BV, Mukherjee A, Pande. Immunoinformatics approach for a novel multi-epitope subunit vaccine design against various subtypes of Influenza A virus. Immunobiology. 2021 Jan 21;226(2):152053. Abstract
submitted by kickingbird at Feb, 1, 2021 from Immunobiology. 2021 Jan 21;226(2):152053 (via https://www.sciencedirect.com/science/article/abs/pii/S01712)
Vaccination is the best strategy for the control and prevention of contagious diseases caused by Influenza A viruses. Extraordinary genetic variability and continual evolvability are responsible for the ...
Reemers S, Verstegen I, Basten S, Hubers W, van de. A broad spectrum HVT-H5 avian influenza vector vaccine which induces a rapid onset of immunity. Vaccine. 2021 Jan 19:S0264-410X(21)00022-0. Abstract
submitted by kickingbird at Jan, 24, 2021 from Vaccine. 2021 Jan 19:S0264-410X(21)00022-0 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Current methods to combat highly pathogenic avian influenza (HPAI) outbreaks in poultry rely on stamping out and preventive culling, which can lead to high economic losses and invoke ethical resistance. ...
Park JA, Kim J, Kim SM, Sohn H, Park C, Kim TH, Le. Fabrication of Electrochemical Influenza Virus (H1N1) Biosensor Composed of Multifunctional DNA Four-Way Junction and Molybdenum Disulfide Hybrid Materia. Materials (Basel). 2021 Jan 12;14(2):E343. Abstract
submitted by kickingbird at Jan, 15, 2021 from Materials (Basel). 2021 Jan 12;14(2):E343 (via https://www.mdpi.com/1996-1944/14/2/343)
The outbreak of the influenza virus (H1N1) has symptoms such as coughing, fever, and a sore throat, and due to its high contagious power, it is fatal to humans. To detect H1N1 precisely, the present study ...
An SH, Hong SM, Son SE, Song JH, Lee CY, Choi JG,. Improvement of PR8-Derived Recombinant Clade 18.104.22.168c H5N6 Vaccine Strains by Optimization of Internal Genes and H103Y Mutation of Hemagglutinin. Vaccines (Basel). 2020 Dec 20;8(4):E781. Abstract
submitted by kickingbird at Jan, 11, 2021 from Vaccines (Basel). 2020 Dec 20;8(4):E781 (via https://www.mdpi.com/2076-393X/8/4/781)
Clade 22.214.171.124c H5N6 avian influenza A viruses (AIVs) may have originally adapted to infect chickens and have caused highly pathogenic avian influenza (HPAI) in poultry and human fatalities. Although A/Puerto ...
Kim JI, Park S, Bae JY, Lee S, Kim J, Kim G, Yoo K. Glycosylation generates an efficacious and immunogenic vaccine against H7N9 influenza virus. PLoS Biol. 2020 Dec 23;18(12):e3001024. Abstract
submitted by kickingbird at Dec, 29, 2020 from PLoS Biol. 2020 Dec 23;18(12):e3001024 (via https://journals.plos.org/plosbiology/article?id=10.1371/jou)
Zoonotic avian influenza viruses pose severe health threats to humans. Of several viral subtypes reported, the low pathogenic avian influenza H7N9 virus has since February 2013 caused more than 1,500 cases ...
Fulvini AA, Tuteja A, Le J, Pokorny BA, Silverman. HA1 (Hemagglutinin) quantitation for influenza A H1N1 and H3N2 high yield reassortant vaccine candidate seed viruses by RP-UPLC. Vaccine. 2020 Dec 16:S0264-410X(20)31563-2. Abstract
submitted by kickingbird at Dec, 22, 2020 from Vaccine. 2020 Dec 16:S0264-410X(20)31563-2 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
The only effective measure to decrease morbidity and mortality caused by the influenza virus in the human population is worldwide vaccination. Vaccination produces neutralizing antibodies that target the ...
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