Wasik BR, et al. Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation. J Virol. 2019 Sep 11. Abstract
submitted by kickingbird at Sep, 14, 2019 from J Virol. 2019 Sep 11 (via https://jvi.asm.org/content/early/2019/09/06/JVI.01039-19)
Influenza A viruses have regularly jumped to new host species to cause epidemics or pandemics, an evolutionary process that involves variation in the viral traits necessary to overcome host barriers and ...
Kim CW, Yoo HJ, Park JH, Oh JE, Lee HK. Exogenous Interleukin-33 Contributes to Protective Immunity via Cytotoxic T-Cell Priming against Mucosal Influenza Viral Infection. Viruses. 2019 Sep 10;11(9).. Abstract
submitted by kickingbird at Sep, 14, 2019 from Viruses. 2019 Sep 10;11(9). (via https://www.mdpi.com/1999-4915/11/9/840)
Influenza is an infectious respiratory illness caused by the influenza virus. Though vaccines against influenza exist, they have limited efficacy. To additionally develop effective treatments, there is ...
Yao L, et al. Identification of antigenic epitopes in the hemagglutinin protein of H7 avian influenza virus. Avian Pathol. 2019 Sep 11. Abstract
submitted by kickingbird at Sep, 14, 2019 from Avian Pathol. 2019 Sep 11 (via https://www.tandfonline.com/doi/abs/10.1080/03079457.2019.16)
The H7 subtype avian influenza virus (AIV) has been reported to infect not only poultry but also humans. The hemagglutinin (HA) protein is the major surface antigen of AIV and plays an important role in ...
Chen Y, Yang Y, Cheng J, Lu J, Hu W. Platelet count and mortality of H7N9 infected patients in Guangdong, China. Platelets. 2019 Sep 11:1-4.. Abstract
submitted by kickingbird at Sep, 14, 2019 from Platelets. 2019 Sep 11:1-4. (via https://www.tandfonline.com/doi/abs/10.1080/09537104.2019.16)
Avian influenza A (H7N9) is a serve zoonosis with a high mortality rate. Timely and effective diagnosis and early warning is crucial for the clinical treatment of H7N9 patients. The previous studies indicated ...
Daikoku T, et al. Growth activation of influenza virus by trypsin and effect of T-705 (favipiravir) on trypsin-optimized growth condition. Acta Virol. 2019;63(3):309-315. Abstract
submitted by kickingbird at Sep, 14, 2019 from Acta Virol. 2019;63(3):309-315 (via http://www.elis.sk/index.php?page=shop.product_details&flypa)
Influenza virus is activated by proteolytic cleavage of hemagglutinin by trypsin. After determining the optimal trypsin concentration, intracellular and extracellular influenza A/PR/8/34 (H1N1) and A/Victoria/361/2011 ...
Densmore CL, et al. Influenza A Virus Detected in Native Bivalves in Waterfowl Habitat of the Delmarva Peninsula, USA. Microorganisms. 2019 Sep 9;7(9).. Abstract
submitted by kickingbird at Sep, 14, 2019 from Microorganisms. 2019 Sep 9;7(9). (via https://www.mdpi.com/2076-2607/7/9/334)
We evaluated the prevalence of influenza A virus (IAV) in different species of bivalves inhabiting natural water bodies in waterfowl habitat along the Delmarva Peninsula and Chesapeake Bay in eastern Maryland. ...
Bai N, Zhang J, Li L, Jin Z. Evaluating the effect of virus mutation on the transmission of avian influenza H7N9 virus in China based on dynamical model. Math Biosci Eng. 2019 Apr 18;16(5):3393-3410.. Abstract
submitted by kickingbird at Sep, 12, 2019 from Math Biosci Eng. 2019 Apr 18;16(5):3393-3410. (via https://www.aimspress.com/article/10.3934/mbe.2019170)
In 2017, the low pathogenic avian influenza H7N9 virus in China had mutated into high pathogenicity to domestic poultry, and led to a large number of poultry death and human cases. To evaluate the effect ...
Saucedo O, Martcheva M, Annor A. Computing human to human Avian influenza R0 via transmission chains and parameter estimation. Math Biosci Eng. 2019 Apr 19;16(5):3465-3487.. Abstract
submitted by kickingbird at Sep, 12, 2019 from Math Biosci Eng. 2019 Apr 19;16(5):3465-3487. (via https://www.aimspress.com/article/10.3934/mbe.2019174)
The transmission of avian influenza between humans is extremely rare, and it mostly affects individuals who are in contact with infected family member. Although this scenario is uncommon, there have been ...
A Andrews M, T Bauch C. Parameterizing a dynamic influenza model using longitudinal versus age-stratified case notifications yields different predictions of vaccine impacts. Math Biosci Eng. 2019 Apr 29;16(5):3753-3770.. Abstract
submitted by kickingbird at Sep, 12, 2019 from Math Biosci Eng. 2019 Apr 29;16(5):3753-3770. (via https://www.aimspress.com/article/10.3934/mbe.2019186)
Dynamic transmission models of influenza are sometimes used in decision-making to identify which vaccination strategies might best reduce influenza-associated health burdens. Our goal was to use laboratory ...
Cui J, Zhang Y, Feng ZL, Guo SB, Zhang Y. Influence of asymptomatic infections for the effectiveness of facemasks during pandemic influenza. Math Biosci Eng. 2019 May 6;16(5):3936-3946. Abstract
submitted by kickingbird at Sep, 12, 2019 from Math Biosci Eng. 2019 May 6;16(5):3936-3946 (via https://www.aimspress.com/article/10.3934/mbe.2019194)
In this paper, the SEIR model is generalized by introducing an asymptomatic class to quantify the influence of wearing N95 facemasks in reducing the spread of influenza H1N1. What's more, we explain the ...
Karo-Karo D, et al. Highly Pathogenic Avian Influenza A(H5N1) Outbreaks in West Java Indonesia 2015-2016: Clinical Manifestation and Associated Risk Factors.. Microorganisms. 2019 Sep 6;7(9).. Abstract
submitted by kickingbird at Sep, 12, 2019 from Microorganisms. 2019 Sep 6;7(9). (via https://www.mdpi.com/2076-2607/7/9/327)
Knowledge of outbreaks and associated risk factors is helpful to improve control of the Highly Pathogenic Avian Influenza A(H5N1) virus (HPAI) in Indonesia. This study was conducted to detect outbreaks ...
Borkenhagen LK, et al. High Risk of Influenza Virus Infection Among Swine Workers: Examining a Dynamic Cohort in China. Clin Infect Dis. 2019 Sep 1.. Abstract
submitted by kickingbird at Sep, 12, 2019 from Clin Infect Dis. 2019 Sep 1. (via https://academic.oup.com/cid/advance-article-abstract/doi/10)
BACKGROUND: China is thought to be a hotspot for zoonotic influenza virus emergence, yet there have been few prospective studies examining the occupational risk of such infections.METHODS: We present the ...
Dreier C, et al. Mutations in the H7 HA and PB1 genes of avian influenza a viruses increase viral pathogenicity and contact transmission in guinea pigs. Emerg Microbes Infect. 2019;8(1):1324-1336.. Abstract
submitted by kickingbird at Sep, 12, 2019 from Emerg Microbes Infect. 2019;8(1):1324-1336. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Avian influenza A viruses (AIV) of the H7 subtype continue to evolve posing a pandemic threat. However, molecular markers of H7N7 AIV pathogenicity and transmission in mammals remain poorly understood. ...
Acosta E, et al. Determinants of Influenza Mortality Trends: Age-Period-Cohort Analysis of Influenza Mortality in the United States, 1959-2016. Demography. 2019 Sep 9. Abstract
submitted by kickingbird at Sep, 12, 2019 from Demography. 2019 Sep 9 (via https://link.springer.com/article/10.1007%2Fs13524-019-00809)
This study examines the roles of age, period, and cohort in influenza mortality trends over the years 1959-2016 in the United States. First, we use Serfling models based on Lexis surfaces to highlight ...
Nakamura K, et al. Systematic evaluation of suspension MDCK cells, adherent MDCK cells, and LLC-MK2 cells for preparing influenza vaccine seed virus. Vaccine. 2019 Sep 6.. Abstract
submitted by kickingbird at Sep, 12, 2019 from Vaccine. 2019 Sep 6. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Suspension Madin-Darby canine kidney (MDCK) cells (MDCK-N), adherent MDCK cells (MDCK-C), and adherent rhesus monkey kidney LLC-MK2 cells (LLC-MK2D) were systematically evaluated for the preparation of ...
Zhang S, et al. Influenza A virus infection induces liver injury in mice. Microb Pathog.2019 Sep 7:103736.. Abstract
submitted by kickingbird at Sep, 12, 2019 from Microb Pathog.2019 Sep 7:103736. (via https://www.sciencedirect.com/science/article/pii/S088240101)
Respiratory infections such as SARS-CoV in humans are often accompanied by mild and self-limiting hepatitis. As a respiratory disease, influenza A virus (IAV) infection can lead to hepatitis, but the mechanism ...
Guan L, et al. H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets. Emerg Microbes Infect. 2019;8(1):1280-1290. Abstract
submitted by kickingbird at Sep, 11, 2019 from Emerg Microbes Infect. 2019;8(1):1280-1290 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
The H3N2 influenza viruses became widespread in humans during the 1968 H3N2 pandemic and have been a major cause of influenza epidemics ever since. Different lineages of H3N2 influenza viruses are also ...
Liu R, et al. Genetic and antigenic characteristics of a human influenza C virus clinical isolate. J Med Virol. 2019 Sep 9. Abstract
submitted by kickingbird at Sep, 11, 2019 from J Med Virol. 2019 Sep 9 (via https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25589)
Unlike influenza A and B viruses that infect humans and cause severe diseases in seasonal epidemics, influenza C virus (ICV) is a ubiquitous childhood pathogen typically causing mild respiratory symptoms. ...
Li J, et al. Delayed peak of human infections and ongoing reassortment of H7N9 avian influenza virus in the newly affected western Chineses provinces during Wave Five. Int J Infect Dis. 2019 Sep 6.. Abstract
submitted by kickingbird at Sep, 11, 2019 from Int J Infect Dis. 2019 Sep 6. (via https://www.ijidonline.com/article/S1201-9712(19)30363-7/pdf)
OBJECTIVES: Eight additional provinces in western China reported human infections for the first time during the fifth wave of human H7N9 infections. Our study aimed to analyze the epidemiological and virological ...
Zhang H, et al. Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection. Bioorg Med Chem Lett. 2019 Aug 24:126639.. Abstract
submitted by kickingbird at Sep, 10, 2019 from Bioorg Med Chem Lett. 2019 Aug 24:126639. (via https://www.sciencedirect.com/science/article/pii/S0960894X1)
Exploration of the chemical space of known influenza polymerase PB2 inhibitor Pimodivir, was performed by our group. We synthesized and identified compounds 16a and 16b, two novel thienopyrimidine derivatives ...
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