Li G, Feng J, Quan K, Sun Z, Yin Y, Yin Y, Chen S,. Generation of an avian influenza DIVA vaccine with a H3-peptide replacement located at HA2 against both highly and low pathogenic H7N9 virus. Virulence. 2022 Dec;13(1):530-541. Abstract
submitted by kickingbird at Mar, 17, 2022 from Virulence. 2022 Dec;13(1):530-541 (via https://www.tandfonline.com/doi/full/10.1080/21505594.2022.2)
A differentiating infected from vaccinated animals (DIVA) vaccine is an ideal strategy for viral eradication in poultry. Here, according to the emerging highly pathogenic H7N9 avian influenza virus (AIV), ...
Engelsma M, Heutink R, Harders F, Germeraad EA, Be. Multiple Introductions of Reassorted Highly Pathogenic Avian Influenza H5Nx Viruses Clade 188.8.131.52b Causing Outbreaks in Wild Birds and Poultry in The Netherlands, 2020-2021. Microbiol Spectr. 2022 Mar 14:e0249921. Abstract
submitted by kickingbird at Mar, 17, 2022 from Microbiol Spectr. 2022 Mar 14:e0249921 (via https://journals.asm.org/doi/10.1128/spectrum.02499-21)
Highly pathogenic avian influenza (HPAI) viruses of subtype H5Nx caused outbreaks in poultry, captive birds, and wild birds in the Netherlands between October 2020 and June 2021. The full genome sequences ...
Zhang M, Xu K, Dai Q, You D, Yu Z, Bao C, Zhao Y. A dynamic model for individualized prognosis prediction in patients with avian influenza A H7N9. Ann Transl Med. 2022 Feb;10(3):149. Abstract
submitted by kickingbird at Mar, 17, 2022 from Ann Transl Med. 2022 Feb;10(3):149 (via https://atm.amegroups.com/article/view/87357/html)
Background: Avian influenza A H7N9 progresses rapidly and has a high case fatality rate. However, few models are available to predict the survival of individual patients with H7N9 infection in real-time. ...
He J, Hou S, Chen Y, Yu JL, Chen QQ, He L, Liu J,. The Epidemiological Pattern and Co-infection of Influenza A and B by Surveillance Network From 2009 to 2014 in Anhui Province, China. Front Public Health. 2022 Feb 24;10:825645. Abstract
submitted by kickingbird at Mar, 17, 2022 from Front Public Health. 2022 Feb 24;10:825645 (via https://www.frontiersin.org/articles/10.3389/fpubh.2022.8256)
Influenza-like illness (ILI) is one of the most important public health problems globally, causing an enormous disease burden. Influenza infections are the most common cause of ILI. Bacterial and virus ...
Milder FJ, Jongeneelen M, Ritschel T, Bouchier P,. Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e21153. Abstract
submitted by kickingbird at Feb, 9, 2022 from Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e21153 (via https://www.pnas.org/content/119/6/e2115379119)
For an efficacious vaccine immunogen, influenza hemagglutinin (HA) needs to maintain a stable quaternary structure, which is contrary to the inherently dynamic and metastable nature of class I fusion proteins. ...
Sun X, Ling Z, Yang Z, Sun B. Broad neutralizing antibody-based strategies to tackle influenza. Curr Opin Virol. 2022 Feb 4;53:101207. Abstract
submitted by kickingbird at Feb, 9, 2022 from Curr Opin Virol. 2022 Feb 4;53:101207 (via https://www.sciencedirect.com/science/article/abs/pii/S18796)
Influenza viruses cause occasional pandemics and annual epidemics, thus persist as a threat to human society. The high variability of viral envelope proteins resulting from antigenic shift and antigenic ...
Chen W, Zhang X, Zhao W, Yang L, Wang Z, Bi H. Environmental factors and spatiotemporal distribution characteristics of the global outbreaks of the highly pathogenic avian influenza H5N1. Environ Sci Pollut Res Int. 2022 Feb 6. Abstract
submitted by kickingbird at Feb, 8, 2022 from Environ Sci Pollut Res Int. 2022 Feb 6 (via https://link.springer.com/article/10.1007/s11356-022-19016-1)
The spread of highly pathogenic avian influenza H5N1 has posed a major threat to global public health. Understanding the spatiotemporal outbreak characteristics and environmental factors of H5N1 outbreaks ...
Huang K, Mao H, Ren P, Zhang Y, Sun X, Zou Z, Jin. 139D in NS1 Contributes to the Virulence of H5N6 Influenza Virus in Mice. Front Vet Sci. 2022 Jan 21;8:808234. Abstract
submitted by kickingbird at Feb, 8, 2022 from Front Vet Sci. 2022 Jan 21;8:808234 (via https://www.frontiersin.org/articles/10.3389/fvets.2021.8082)
H5N6, the highly pathogenic avian influenza A virus (IAV) of clade 184.108.40.206, causes global outbreaks in poultry. H5N6 has become the dominant IAV subtype in waterfowls and causes human infections with high ...
Bu L, Chen B, Xing L, Cai X, Liang S, Zhang L,Wang. Generation of a pdmH1N1 2018 Influenza A Reporter Virus Carrying a mCherry Fluorescent Protein in the PA Segment. Front Cell Infect Microbiol. 2022 Jan 20;11:827790. Abstract
submitted by kickingbird at Feb, 8, 2022 from Front Cell Infect Microbiol. 2022 Jan 20;11:827790 (via https://www.frontiersin.org/articles/10.3389/fcimb.2021.8277)
Influenza A virus (IAV) is a major human pathogen associated with significant morbidity and mortality worldwide. Through serial passage in mice, we generated a recombinant pdmH1N1 2009 IAV, A/Guangdong/GLW/2018 ...
Channa AA, Tariq M, Nizamani ZA, Kalhoro NH. Prevalence of avian influenza H5, H7, and H9 viruses in commercial layers in Karachi, Pakistan. Iran J Vet Res. 2021 Fall;22(4):352-355. Abstract
submitted by kickingbird at Feb, 8, 2022 from Iran J Vet Res. 2021 Fall;22(4):352-355 (via https://ijvr.shirazu.ac.ir/article_6347.html)
Background: Avian influenza viruses (AIVs) cause significant harm to the poultry industry due to mortality as well as high morbidity along with the risk of potential zoonotic transmission to humans.Aims: ...
Zheng Y, Guo Y, Li Y, Liang B, Sun X, Li S, Xia H,. The molecular determinants of antigenic drift in a novel avian influenza A (H9N2) variant virus. Virol J. 2022 Feb 5;19(1):26. Abstract
submitted by kickingbird at Feb, 8, 2022 from Virol J. 2022 Feb 5;19(1):26 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: In early 2020, a novel H9N2 AIV immune escape variant emerged in South China and rapidly spread throughout mainland China. The effectiveness of the current H9N2 vaccine is being challenged ...
Tian Y, Lee J, van der Maaden K, Bhide Y, de Vries. Intradermal administration of influenza vaccine with trehalose and pullulan-based dissolving microneedle arrays. J Pharm Sci. 2022 Feb 2:S0022-3549(22)00042-9. Abstract
submitted by kickingbird at Feb, 8, 2022 from J Pharm Sci. 2022 Feb 2:S0022-3549(22)00042-9 (via https://jpharmsci.org/article/S0022-3549(22)00042-9/fulltext)
Most influenza vaccines are administered via intramuscular injection which has several disadvantages that might jeopardize the compliance of vaccinees. Intradermal administration of dissolving-microneedle-arrays ...
Gu M, Zhao Y, Ge Z, Li Y, Gao R, Wang X, Hu J, Liu. Effects of HA2 154 deglycosylation and NA V202I mutation on biological property of H5N6 subtype avian influenza virus. Vet Microbiol. 2022 Jan 22;266:109353. Abstract
submitted by kickingbird at Feb, 7, 2022 from Vet Microbiol. 2022 Jan 22;266:109353 (via https://www.sciencedirect.com/science/article/pii/S037811352)
In recent years, clade 220.127.116.11 H5N6 subtype avian influenza virus (AIV) has been predominantly prevalent in poultry flocks in China. During our AIV surveillance in 2018-2019, 6 circulating strains of H5N6 ...
Seibert B, Cardenas-Garcia S, Rajao D, Perez DR. Reverse Genetics for Influenza A and B Viruses Driven by Swine Polymerase I Promoter. Methods Mol Biol. 2022;2465:257-281. Abstract
submitted by kickingbird at Feb, 5, 2022 from Methods Mol Biol. 2022;2465:257-281 (via https://link.springer.com/protocol/10.1007%2F978-1-0716-2168)
Influenza viruses are considered prominent pathogens of humans and animals that are extensively investigated because of public health importance. Plasmid-based reverse genetics is a fundamental tool that ...
Nogales A, Chiem K, Breen M, DeDiego ML, Parrish C. Generation and Characterization of Single-Cycle Infectious Canine Influenza A Virus (sciCIV) and Its Use as Vaccine Platform. Methods Mol Biol. 2022;2465:227-255. Abstract
submitted by kickingbird at Feb, 5, 2022 from Methods Mol Biol. 2022;2465:227-255 (via https://link.springer.com/protocol/10.1007%2F978-1-0716-2168)
Influenza A viruses (IAVs) infect a broad range of hosts, including multiple avian and mammalian species. The frequent emergence of novel IAV strains in different hosts, including in humans, results in ...
Li Z, Kim KH, Bhatnagar N, Park BR, Jeeva S, Jung. Physical radiofrequency adjuvant enhances immune responses to influenza H5N1 vaccination. FASEB J. 2022 Mar;36(3):e22182.. Abstract
submitted by kickingbird at Feb, 4, 2022 from FASEB J. 2022 Mar;36(3):e22182. (via https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.2021017)
Pre-pandemic influenza H5N1 vaccine has relatively low immunogenicity and often requires high antigen amounts and two immunizations to induce protective immunity. Incorporation of vaccine adjuvants is ...
Aufi IM, Khudhair AM, Ghaeb Al-Saadi L, Almoneem A. Epidemiology and Molecular Characterization of Seasonal Influenza Viruses in Iraq. Arch Razi Inst. 2021 Oct 31;76(4):871-877. Abstract
submitted by kickingbird at Feb, 2, 2022 from Arch Razi Inst. 2021 Oct 31;76(4):871-877 (via https://archrazi.areeo.ac.ir/article_124958.html)
The importance of influenza viruses in respiratory infections in the Middle East, including Iraq, has been historically overlooked. Nowadays, with the pandemic of corona virus disease 2019, the importance ...
Osthus D. Fast and accurate influenza forecasting in the United States with Inferno. PLoS Comput Biol. 2022 Jan 31;18(1):e1008651. Abstract
submitted by kickingbird at Feb, 2, 2022 from PLoS Comput Biol. 2022 Jan 31;18(1):e1008651 (via https://journals.plos.org/ploscompbiol/article?id=10.1371/jo)
Infectious disease forecasting is an emerging field and has the potential to improve public health through anticipatory resource allocation, situational awareness, and mitigation planning. By way of exploring ...
Yehia N, Erfan AM, Adel A, El-Tayeb A, Hassan WMM,. Pathogenicity of three genetically distinct and highly pathogenic Egyptian H5N8 avian influenza viruses in chickens. Poult Sci. 2021 Dec 10;101(3):101662. Abstract
submitted by kickingbird at Feb, 2, 2022 from Poult Sci. 2021 Dec 10;101(3):101662 (via https://www.sciencedirect.com/science/article/pii/S003257912)
In late 2016, Egypt encountered multiple cases of the highly pathogenic avian influenza (HPAI) virus of the H5N8 subtype. In a previous study, three distinct genotypes, including A/common-coot/Egypt/CA285/2016 ...
Bianchini EA, Bogiatto RJ, Donatello RA, Casazza M. Host Correlates of Avian Influenza Virus Infection in Wild Waterfowl of the Sacramento Valley, California. Avian Dis. 2021 Dec 22. Abstract
submitted by kickingbird at Jan, 30, 2022 from Avian Dis. 2021 Dec 22 (via https://bioone.org/journals/avian-diseases/volume-66/issue-1)
Avian influenza viruses (AIVs) are distributed globally in members of the family Anatidae (waterfowl), and significant disease may occur when these viruses infect commercial poultry or humans. Early detection ...
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