Yanmei Hu, et al. Structure–Property Relationship Studies of Influenza A Virus AM2-S31N Proton Channel Blockers. ACS Med. Chem. Lett.. Abstract
submitted by kickingbird at Oct, 26, 2018 from ACS Med. Chem. Lett. (via https://pubs.acs.org/doi/abs/10.1021/acsmedchemlett.8b00336)
Majority of current circulating influenza A viruses carry the S31N mutation in their M2 genes, rendering AM2-S31N as a high profile antiviral drug target. With our continuous interest in developing AM2-S31N ...
Duwell MM, Blythe D, Radebaugh MW, et al. Influenza A(H3N2) Variant Virus Outbreak at Three Fairs - Maryland, 2017. MMWR Morb Mortal Wkly Rep 2018;67:1169–1173.. Abstract
submitted by kickingbird at Oct, 26, 2018 from MMWR Morb Mortal Wkly Rep 2018;67:1169–1173. (via https://www.cdc.gov/mmwr/volumes/67/wr/mm6742a1.htm)
On September 17, 2017, the Maryland Department of Agriculture (MDA) was notified by fair and 4-H officials of ill swine at agricultural fair A, held September 14–17. That day, investigation of the 107 ...
Yu G, Tsan-Yuk Lam T, Zhu H, Guan Y. Two methods for mapping and visualizing associated data on phylogeny using ggtree. Mol Biol Evol. 2018 Oct 23.. Abstract
submitted by kickingbird at Oct, 24, 2018 from Mol Biol Evol. 2018 Oct 23. (via https://www.ncbi.nlm.nih.gov/pubmed/30351396)
Ggtree is a comprehensive R package for visualizing and annotating phylogenetic trees with associated data. It can also map and visualize associated external data on phylogenies with two general methods. ...
Teirlinck AC, et al. The incidence of symptomatic infection with influenza virus in the Netherlands 2011/2012 through 2016/2017, estimated using Bayesian evidence synthesis. Epidemiol Infect. 2018 Oct 23:1-6. Abstract
submitted by kickingbird at Oct, 24, 2018 from Epidemiol Infect. 2018 Oct 23:1-6 (via https://www.ncbi.nlm.nih.gov/pubmed/30348244)
Due to differences in the circulation of influenza viruses, distribution and antigenic drift of A subtypes and B lineages, and susceptibility to infection in the population, the incidence of symptomatic ...
Denney L, Ho LP. The role of respiratory epithelium in host defence against influenza virus infection. Biomed J. 2018 Aug;41(4):218-233.. Abstract
submitted by kickingbird at Oct, 24, 2018 from Biomed J. 2018 Aug;41(4):218-233. (via https://www.ncbi.nlm.nih.gov/pubmed/30348265)
The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis ...
Toledo-Rueda W, et al. Antiviral resistance markers in influenza virus sequences in Mexico, 2000~2017. Infect Drug Resist. 2018 Oct 11;11:1751-1756. Abstract
submitted by kickingbird at Oct, 24, 2018 from Infect Drug Resist. 2018 Oct 11;11:1751-1756 (via https://www.ncbi.nlm.nih.gov/pubmed/30349332)
Background: Influenza causes high rates of morbidity and mortality. Genetic variability of influenza viruses generates resistance to antivirals, which are of two types, since they act on two different ...
Credille CV, et al. Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. J Med Chem. 2018 Oct 16. Abstract
submitted by kickingbird at Oct, 24, 2018 from J Med Chem. 2018 Oct 16 (via https://www.ncbi.nlm.nih.gov/pubmed/30351002)
Metalloenzymes represent an important target space for drug discovery. A limitation to the early development of metalloenzyme inhibitors has been the lack of established structure-activity relationships ...
Gong YN, Kuo RL, Chen GW, Shih SR. Centennial review of influenza in Taiwan. Biomed J. 2018 Aug;41(4):234-241.. Abstract
submitted by kickingbird at Oct, 24, 2018 from Biomed J. 2018 Aug;41(4):234-241. (via https://www.ncbi.nlm.nih.gov/pubmed/30348266)
The history of influenza in Taiwan can be traced up to the 1918 H1N1 Spanish flu pandemic, followed by several others including the 1957 H2N2, 1968 H3N2, and the 2009 new H1N1. A couple of avian influenza ...
Delgadillo-Gutiérrez K, et al. Stability of retroviral pseudotypes carrying the hemagglutinin of avian influenza viruses under various storage conditions. J Virol Methods. 2018 Oct 19.. Abstract
submitted by kickingbird at Oct, 23, 2018 from J Virol Methods. 2018 Oct 19. (via https://www.ncbi.nlm.nih.gov/pubmed/30347199)
Retroviral pseudotypes are broadly used as safe instruments to mimic the structure and surface of highly pathogenic viruses. They have been employed for the discovery of new drugs, as diagnostic tools ...
Davis RL, et al. The culture of primary duck endothelial cells for the study of avian influenza. BMC Microbiol. 2018 Oct 19;18(1):138. Abstract
submitted by kickingbird at Oct, 22, 2018 from BMC Microbiol. 2018 Oct 19;18(1):138 (via https://www.ncbi.nlm.nih.gov/pubmed/30340527)
BACKGROUND: Endothelial cells play a major role in highly pathogenic avian influenza (HPAI) virus pathogenesis in gallinaceous poultry species (e.g. chicken, turkey and quail). Upon infection of gallinaceous ...
Ye S, Cowled CJ, Yap CH, Stambas J. Deep sequencing of primary human lung epithelial cells challenged with H5N1 influenza virus reveals a proviral role for CEACAM1. Sci Rep. 2018 Oct 19;8(1):15468.. Abstract
submitted by kickingbird at Oct, 21, 2018 from Sci Rep. 2018 Oct 19;8(1):15468. (via https://www.ncbi.nlm.nih.gov/pubmed/30341336)
Current prophylactic and therapeutic strategies targeting human influenza viruses include vaccines and antivirals. Given variable rates of vaccine efficacy and antiviral resistance, alternative strategies ...
Pillsbury AJ, et al. Active surveillance of 2017 seasonal influenza vaccine safety: an observational cohort study of individuals aged 6 months and older in Australia. BMJ Open. 2018 Oct 18;8(10):e023263.. Abstract
submitted by kickingbird at Oct, 21, 2018 from BMJ Open. 2018 Oct 18;8(10):e023263. (via https://www.ncbi.nlm.nih.gov/pubmed/30341132)
OBJECTIVE: To actively solicit adverse events experienced in the days following immunisation with quadrivalent inactivated influenza vaccine using Australia's near real-time, participant-based vaccine ...
Bartsch SM, et al. Epidemiologic and economic impact of pharmacies as vaccination locations during an influenza epidemic. Vaccine. 2018 Oct 5.. Abstract
submitted by kickingbird at Oct, 21, 2018 from Vaccine. 2018 Oct 5. (via https://www.ncbi.nlm.nih.gov/pubmed/30340884)
INTRODUCTION: During an influenza epidemic, where early vaccination is crucial, pharmacies may be a resource to increase vaccine distribution reach and capacity.METHODS: We utilized an agent-based model ...
St Charles KM, et al. Avian Influenza in the U.S. Commercial Upland Game Bird Industry: An Analysis of Selected Practices as Potential Exposure Pathways and Surveillance System Data Reporting. Avian Dis. 2018 Sep;62(3):307-315.. Abstract
submitted by kickingbird at Oct, 21, 2018 from Avian Dis. 2018 Sep;62(3):307-315. (via https://www.ncbi.nlm.nih.gov/pubmed/30339513)
Producing a smaller yield of higher-value birds compared to conventional poultry production, the U.S. commercial upland game bird industry deals primarily in the sale of live birds for recreational hunting. ...
Ge Y, et al. Detection of reassortant avian influenza A (H11N9) virus in wild birds in China. Transbound Emerg Dis. 2018 Oct 19. Abstract
submitted by kickingbird at Oct, 21, 2018 from Transbound Emerg Dis. 2018 Oct 19 (via https://www.ncbi.nlm.nih.gov/pubmed/30338936)
Human infectious avian influenza virus (AIV) H7N9 emerged in China in 2013. The N9 gene of H7N9, which has the ability to cause death in humans, originated from an H11N9 influenza strain circulating in ...
Chen P, Chen E, Chen L, Zhou XJ, Liu R. Detecting early-warning signals of influenza outbreak based on dynamic network marker. J Cell Mol Med. 2018 Oct 19.. Abstract
submitted by kickingbird at Oct, 21, 2018 from J Cell Mol Med. 2018 Oct 19. (via https://www.ncbi.nlm.nih.gov/pubmed/30338927)
The seasonal outbreaks of influenza infection cause globally respiratory illness, or even death in all age groups. Given early-warning signals preceding the influenza outbreak, timely intervention such ...
Sun Y, et al. Aflatoxin B1 Promotes Influenza Replication and Increases Virus Related Lung Damage via Activation of TLR4 Signaling. Front Immunol. 2018 Oct 4;9:2297. Abstract
submitted by kickingbird at Oct, 21, 2018 from Front Immunol. 2018 Oct 4;9:2297 (via https://www.ncbi.nlm.nih.gov/pubmed/30337931)
Aflatoxin B1 (AFB1), which alters immune responses to mammals, is one of the most common mycotoxins in feeds and food. Swine influenza virus (SIV) is a major pathogen of both animals and humans. However, ...
Hughes HR, Brockmeier SL, Loving CL. Bordetella bronchiseptica Colonization Limits Efficacy, but Not Immunogenicity, of Live-Attenuated Influenza Virus Vaccine and Enhances Pathogenesis After Influenza Challenge. Front Immunol. 2018 Oct 4;9:2255. Abstract
submitted by kickingbird at Oct, 21, 2018 from Front Immunol. 2018 Oct 4;9:2255 (via https://www.ncbi.nlm.nih.gov/pubmed/30337924)
Intranasally administered live-attenuated influenza virus (LAIV) vaccines provide significant protection against heterologous influenza A virus (IAV) challenge. However, LAIV administration can modify ...
Gopal R, et al. STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection. Front Immunol. 2018 Sep 25;9:2151. Abstract
submitted by kickingbird at Oct, 21, 2018 from Front Immunol. 2018 Sep 25;9:2151 (via https://www.ncbi.nlm.nih.gov/pubmed/30337919)
Influenza is a common respiratory virus that infects between 5 and 20% of the US population and results in 30,000 deaths annually. A primary cause of influenza-associated death is secondary bacterial pneumonia. ...
Lisovski S, et al. The roles of migratory and resident birds in local avian influenza infection dynamics. J Appl Ecol. 2018 Nov;55(6):2963-2975.. Abstract
submitted by kickingbird at Oct, 21, 2018 from J Appl Ecol. 2018 Nov;55(6):2963-2975. (via https://www.ncbi.nlm.nih.gov/pubmed/30337766)
Migratory birds are an increasing focus of interest when it comes to infection dynamics and the spread of avian influenza viruses (AIV). However, we lack detailed understanding migratory birds' contribution ...
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