Limburg H, et al. TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes. J Virol. 2019 Aug 7. Abstract
submitted by kickingbird at Aug, 11, 2019 from J Virol. 2019 Aug 7 (via https://jvi.asm.org/content/early/2019/08/05/JVI.00649-19)
Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is essential for virus infectivity and spread. We previously demonstrated in vitro that the transmembrane protease TMPRSS2 cleaves ...
Jha A, et al. Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza. Eur Respir J. 2019 Aug 7.. Abstract
submitted by kickingbird at Aug, 11, 2019 from Eur Respir J. 2019 Aug 7. (via https://erj.ersjournals.com/content/early/2019/07/31/1399300)
BACKGROUND: Patients with asthma are at risk of hospitalisation with influenza, but the reasons for this predisposition are unknown.STUDY SETTING: A prospective observational study of adults with PCR-confirmed ...
Jin F, et al. A Single Mutation N166D in Hemagglutinin Affects Antigenicity and Pathogenesis of H9N2 Avian Influenza Virus. Viruses. 2019 Aug 2;11(8).. Abstract
submitted by kickingbird at Aug, 8, 2019 from Viruses. 2019 Aug 2;11(8). (via https://www.mdpi.com/1999-4915/11/8/709)
Some immune escape mutants of H9N2 virus and the corresponding mutations in hemagglutinin (HA) have been documented, but little is known about the impact of a single mutation on the antigenicity and pathogenesis ...
Ren X, et al. Avian Influenza A Virus Polymerase Recruits Cellular RNA Helicase eIF4A3 to Promote Viral mRNA Splicing and Spliced mRNA Nuclear Export. Front Microbiol. 2019 Jul 16;10:1625.. Abstract
submitted by kickingbird at Aug, 8, 2019 from Front Microbiol. 2019 Jul 16;10:1625. (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0162)
The influenza A virus replicates in a broad range of avian and mammalian species by hijacking cellular factors and processes. Avian influenza A viruses (AIVs) generally propagated poorly in mammalian cells, ...
Naguib MM, et al. Global patterns of avian influenza A(H7): virus evolution and zoonotic threats. FEMS Microbiol Rev. 2019 Aug 5. Abstract
submitted by kickingbird at Aug, 8, 2019 from FEMS Microbiol Rev. 2019 Aug 5 (via https://academic.oup.com/femsre/advance-article/doi/10.1093/)
Avian influenza viruses (AIVs) continue to impose a negative impact on animal and human health worldwide. In particular, the emergence of highly pathogenic AIV H5 and, more recently, the emergence of low ...
Yang J, Wang Z, Du Y, Jia Y, Wang L, Xu S, Zhu Q. Clade 188.8.131.52 H5N1 avian influenza viruses circulate at the interface of migratory and domestic birds around Qinghai Lake in China. Vet Microbiol. 2019 Aug;235:234-242. Abstract
submitted by kickingbird at Aug, 8, 2019 from Vet Microbiol. 2019 Aug;235:234-242 (via https://www.sciencedirect.com/science/article/pii/S037811351)
During 2012-2015, six H5N1 avian influenza viruses were isolated from domestic birds and the environment around Qinghai Lake. Phylogenetic analysis of HA genes revealed that A/chicken/Gansu/XG2/2012 (CK/GS/XG2/12) ...
Tzeng TT, et al. The stability and immunogenicity of inactivated MDCK cell-derived influenza H7N9 viruses. Vaccine. 2019 Aug 2. Abstract
submitted by kickingbird at Aug, 8, 2019 from Vaccine. 2019 Aug 2 (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
In recent years, cell-based influenza vaccines have gained a great interest over the egg-based vaccines. Several inactivated H7N9 vaccines have been evaluated in clinical trials, including whole-virion ...
Yang J, Müller NF, Bouckaert R, Xu B, Drummond AJ. Bayesian phylodynamics of avian influenza A virus H9N2 in Asia with time-dependent predictors of migration. PLoS Comput Biol. 2019 Aug 6;15(8):e1007189.. Abstract
submitted by kickingbird at Aug, 8, 2019 from PLoS Comput Biol. 2019 Aug 6;15(8):e1007189. (via https://journals.plos.org/ploscompbiol/article?id=10.1371/jo)
Model-based phylodynamic approaches recently employed generalized linear models (GLMs) to uncover potential predictors of viral spread. Very recently some of these models have allowed both the predictors ...
Liu J, et al. Genetic characterization of influenza A virus and assessment of vaccine efficacy in Yantai from 2014 to 2017. Zhonghua Yu Fang Yi Xue Za Zhi. 2019 Aug 6;53(8):8. Abstract
submitted by kickingbird at Aug, 8, 2019 from Zhonghua Yu Fang Yi Xue Za Zhi. 2019 Aug 6;53(8):8 (via https://www.ncbi.nlm.nih.gov/pubmed/31378046)
In this study, the swabs were collected among patients with an influenza-like illness (ILI) admitted to 2 sentinel surveillance hospitals of Yantai from April 2014 to August 2017. All specimen were cultured ...
Shi W, et al. Co-circulation and persistence of multiple A/H3N2 influenza variants in China. Emerg Microbes Infect. 2019;8(1):1157-1167. Abstract
submitted by kickingbird at Aug, 4, 2019 from Emerg Microbes Infect. 2019;8(1):1157-1167 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
The spread of influenza A/H3N2 variants possessing the hemagglutinin 121?K mutation and the unexpectedly high incidence of influenza in the 2017-2018 northern hemisphere influenza season have raised serious ...
Yang Y, et al. Clinical and virological characteristics of human infections with H7N9 avian influenza virus in Shenzhen, China, 2013~2017. J Infect. 2019 Jul 30.. Abstract
submitted by kickingbird at Aug, 4, 2019 from J Infect. 2019 Jul 30. (via https://www.journalofinfection.com/article/S0163-4453(19)302)
Recent articles in this Journal have reported the human infections with highly pathogenic (HP) H7N9 avian influenza virus (AIV) in Shenzhen city of China, and compared the clinical and virological characteristics ...
Weng CF, et al. Association between the Risk of Lung Cancer and Influenza: A Population-Based Nested Case-Control Study. Int J Infect Dis. 2019 Jul 30.. Abstract
submitted by kickingbird at Aug, 4, 2019 from Int J Infect Dis. 2019 Jul 30. (via https://www.ijidonline.com/article/S1201-9712(19)30315-7/pdf)
BACKGROUND: Previous animal studies have shown that certain respiratory oncoviruses can lead to tumorigenesis, especially influenza virus. However, no clinical studies other than animal studies have been ...
Wong JY, Goldstein E, Fang VJ, Cowling BJ, Wu P. Real-time estimation of the influenza-associated excess mortality in Hong Kong. Epidemiol Infect. 2019 Jan;147:e217. Abstract
submitted by kickingbird at Aug, 2, 2019 from Epidemiol Infect. 2019 Jan;147:e217 (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
Statistical models are commonly employed in the estimation of influenza-associated excess mortality that, due to various reasons, is often underestimated by laboratory-confirmed influenza deaths reported ...
Komadina N, et al. Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections. Epidemiol Infect. 2019 Jan;147:e213.. Abstract
submitted by kickingbird at Aug, 2, 2019 from Epidemiol Infect. 2019 Jan;147:e213. (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
The epidemiology of H5N1 and H7N9 avian viruses of humans infected in China differs despite both viruses being avian reassortants that have inherited six internal genes from a common ancestor, H9N2. The ...
Lin RW, et al. Naturally occurring mutations in PB1 affect influenza A virus replication fidelity, virulence, and adaptability. J Biomed Sci. 2019 Jul 31;26(1):55. Abstract
submitted by kickingbird at Aug, 2, 2019 from J Biomed Sci. 2019 Jul 31;26(1):55 (via https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929)
BACKGROUND: Mutations in the PB1 subunit of RNA-dependent RNA polymerase (RdRp) of influenza A virus can affect replication fidelity. Before the influenza A/H1N1 pandemic in 2009, most human influenza ...
?wi?toń E, et al. Evolution of H9N2 low pathogenic avian influenza virus during passages in chickens. Infect Genet Evol. 2019 Jul 24:103979.. Abstract
submitted by kickingbird at Jul, 30, 2019 from Infect Genet Evol. 2019 Jul 24:103979. (via https://www.sciencedirect.com/science/article/pii/S156713481)
The process of avian influenza virus (AIV) evolution in a new host was investigated in the experiment in which ten serial passages of a turkey-derived H9N2 AIV were carried out in specific pathogen free ...
Andrews SF, et al. Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin. Immunity. 2019 Jul 16. Abstract
submitted by kickingbird at Jul, 30, 2019 from Immunity. 2019 Jul 16 (via https://www.cell.com/immunity/fulltext/S1074-7613(19)30294-8)
Vaccine-induced memory B cell responses to evolving viruses like influenza A involve activation of pre-existing immunity and generation of new responses. To define the contribution of these two types of ...
Ng K, et al. Responses of human mast cells and epithelial cells following exposure to influenza A virus. Antiviral Res. 2019 Jul 23:104566. Abstract
submitted by kickingbird at Jul, 30, 2019 from Antiviral Res. 2019 Jul 23:104566 (via https://www.sciencedirect.com/science/article/pii/S016635421)
As a part of innate immune defense, the role of mast cells during viral replication has been incompletely understood. In this study, we characterized and compared the responses of the human mast cell line, ...
Wang J, et al. First outbreak of human infection with avian influenza A(H7N9) virus in Guangxi, China, 2016 to 2017. Chin Med J (Engl). 2019 Jul 24. Abstract
submitted by kickingbird at Jul, 30, 2019 from Chin Med J (Engl). 2019 Jul 24 (via https://insights.ovid.com/crossref?an=00029330-900000000-997)
First outbreak of human infection with avian influenza A(H7N9) virus in Guangxi, China, 2016 to 2017
Eickhoff CS, et al. Highly conserved influenza T cell epitopes induce broadly protective immunity. Vaccine. 2019 Jul 19. Abstract
submitted by kickingbird at Jul, 27, 2019 from Vaccine. 2019 Jul 19 (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Influenza world-wide causes significant morbidity and mortality annually, and more severe pandemics when novel strains evolve to which humans are immunologically na?ve. Because of the high viral mutation ...
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