Brazee PL, et al. Linear ubiquitin assembly complex regulates lung epithelial driven responses during influenza infection. J Clin Invest. 2019 Nov 12.. Abstract
submitted by kickingbird at Nov, 14, 2019 from J Clin Invest. 2019 Nov 12. (via https://www.jci.org/articles/view/128368)
Influenza A virus (IAV) is among the most common causes of pneumonia related death worldwide. Pulmonary epithelial cells are the primary target for viral infection and replication and respond by releasing ...
Wang S, et al. Reverse transcription recombinase-aided amplification assay for H7 subtype avian influenza virus. Transbound Emerg Dis. 2019 Nov 12.. Abstract
submitted by kickingbird at Nov, 14, 2019 from Transbound Emerg Dis. 2019 Nov 12. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13411)
H7 subtype avian influenza virus infection is an emerging zoonosis in some Asian countries and an important avian disease worldwide. A rapid and simple test is needed to confirm infection in suspected ...
Muzyka D, et al. Highly Pathogenic and Low Pathogenic Avian Influenza H5 Subtype Viruses in Wild Birds in Ukraine. Avian Dis. 2019 Mar 1;63(sp1):235-245.. Abstract
submitted by kickingbird at Nov, 14, 2019 from Avian Dis. 2019 Mar 1;63(sp1):235-245. (via https://www.ncbi.nlm.nih.gov/pubmed/31713401)
There have been three waves of highly pathogenic avian influenza (HPAI) outbreaks in commercial, backyard poultry, and wild birds in Ukraine. The first (2005-2006) and second (2008) waves were caused by ...
Sultan HA, et al. Efficacy of Clade 2.3.2 H5-Recombinant Baculovirus Vaccine in Protecting Muscovy and Pekin Ducks from Clade 126.96.36.199 H5N8 Highly Pathogenic Avian Influenza Infection. Avian Dis. 2019 Mar 1;63(sp1):219-229.. Abstract
submitted by kickingbird at Nov, 14, 2019 from Avian Dis. 2019 Mar 1;63(sp1):219-229. (via https://www.ncbi.nlm.nih.gov/pubmed/31713400)
In late 2016, a highly pathogenic avian influenza (HPAI) virus subtype H5N8 clade 188.8.131.52 was reported in Egypt in migratory birds; subsequently, the virus spread to backyard and commercial poultry in ...
Schreiber A, et al. Type I interferon antagonistic properties of Influenza B virus polymerase proteins. Cell Microbiol. 2019 Nov 11:e13143. Abstract
submitted by kickingbird at Nov, 14, 2019 from Cell Microbiol. 2019 Nov 11:e13143 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.13143)
The innate immune system, in particular the type I interferon (IFN) response, is a powerful defense against virus infections. In turn, many if not all viruses have evolved various means to circumvent, ...
Antanasijevic A, Durst MA, Lavie A, Caffrey M. Identification of a pH Sensor in Influenza Hemagglutinin using X-ray Crystallography. J Struct Biol. 2019 Nov 2:107412. Abstract
submitted by kickingbird at Nov, 11, 2019 from J Struct Biol. 2019 Nov 2:107412 (via https://www.ncbi.nlm.nih.gov/pubmed/31689502)
Hemagglutnin (HA) mediates entry of influenza virus through a series of conformational changes triggered by the low pH of the endosome. The residue or combination of residues acting as pH sensors has not ...
Kwon HI, et al. A Novel Neuraminidase-Dependent Hemagglutinin Cleavage Mechanism Enables the Systemic Spread of an H7N6 Avian Influenza Virus. MBio. 2019 Nov 5;10(6). Abstract
submitted by kickingbird at Nov, 11, 2019 from MBio. 2019 Nov 5;10(6) (via https://mbio.asm.org/content/10/6/e02369-19)
n this study, we demonstrate a novel mechanism for hemagglutinin (HA) activation in a naturally occurring H7N6 avian influenza A virus strain, A/mallard duck/Korea/6L/2007 (A/Mdk/6L/07). This novel mechanism ...
Seki M, Sakai-Tagawa Y, Yasuhara A, Watanabe Y. Adult influenza A (H3N2) with reduced susceptibility to baloxavir or peramivir cured after switching anti-influenza agents. IDCases. 2019 Oct 1;18:e00650.. Abstract
submitted by kickingbird at Nov, 11, 2019 from IDCases. 2019 Oct 1;18:e00650. (via https://www.ncbi.nlm.nih.gov/pubmed/31692637)
We describe two adults with A/H3N2 influenza with (patient 1), and without (patient 2) polymerase acidic (PA) subunit I38?T substitution during the same season. Patient 1 had a reduced clinical response ...
Coombs KM, et al. Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses. Viruses. 2019 Nov 5;11(11).. Abstract
submitted by kickingbird at Nov, 11, 2019 from Viruses. 2019 Nov 5;11(11). (via https://www.mdpi.com/1999-4915/11/11/1028)
Influenza A viruses (IAVs) are important animal and human emerging and re-emerging pathogens that are responsible for yearly seasonal epidemics and sporadic pandemics. IAVs cause a wide range of clinical ...
Gambaryan AS, et al. Changes in the Receptor-Binding Properties of H3N2 Viruses during Long-Term Circulation in Humans. Biochemistry (Mosc). 2019 Oct;84(10):1177-1185. Abstract
submitted by kickingbird at Nov, 11, 2019 from Biochemistry (Mosc). 2019 Oct;84(10):1177-1185 (via https://www.ncbi.nlm.nih.gov/pubmed/31694513)
It was previously shown that hemagglutinin residues Thr155, Glu158, and Ser228 are crucial for the recognition of Neu5Gc. In this study, we demonstrated that the ability to bind the Neu5Gc-terminated receptor ...
Brown JC, Barclay WS, Galiano M, Harvey R. Passage of influenza A/H3N2 viruses in human airway cells removes artefactual variants associated with neuraminidase-mediated binding. J Gen Virol. 2019 Nov 8.. Abstract
submitted by kickingbird at Nov, 11, 2019 from J Gen Virol. 2019 Nov 8. (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Serological assays with modern influenza A/H3N2 viruses have become problematic due to the progressive reduction in the ability of viruses of this subtype to bind and agglutinate red blood cells (RBCs). ...
Chen F, Liu T, Xu J, Huang Y, Liu S, Yang J. Key amino acid residues of neuraminidase involved in influenza A virus entry. Pathog Dis. 2019 Nov 8.. Abstract
submitted by kickingbird at Nov, 11, 2019 from Pathog Dis. 2019 Nov 8. (via https://academic.oup.com/femspd/advance-article-abstract/doi)
Generally, influenza virus neuraminidase (NA) plays a critical role in the release stage of influenza virus. Recently, it has been found that NA may promote influenza virus to access the target cells. ...
Baek YG, et al. A novel reassortant clade 184.108.40.206 highly pathogenic avian influenza H5N6 virus identified in South Korea in 2018. Infect Genet Evol. 2019 Nov 1:104056.. Abstract
submitted by kickingbird at Nov, 7, 2019 from Infect Genet Evol. 2019 Nov 1:104056. (via https://www.ncbi.nlm.nih.gov/pubmed/31683010)
Since 2017, clade 220.127.116.11b H5N6 highly pathogenic avian influenza viruses (HPAIVs) have been detected over a broad geographic region, including Eurasia. These viruses have evolved through reassortment ...
Tapia F, Laske T, Wasik MA, Rammhold M, Genzel Y. Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times-Insights From qPCR Measurements and Viral Dynamics Modeling. Front Bioeng Biotechnol. 2019 Oct 18;7:275. Abstract
submitted by kickingbird at Nov, 7, 2019 from Front Bioeng Biotechnol. 2019 Oct 18;7:275 (via https://www.frontiersin.org/articles/10.3389/fbioe.2019.0027)
Defective interfering particles (DIPs) are a natural byproduct of influenza A virus (IAV) replication. DIPs interfere with the propagation and spread of infectious standard virus (STV), reduce virus yields ...
Zhang F, et al. Phenotypic Characterization of Chinese Rhesus Macaque Plasmablasts for Cloning Antigen-Specific Monoclonal Antibodies. Front Immunol. 2019 Oct 11;10:2426. Abstract
submitted by kickingbird at Nov, 7, 2019 from Front Immunol. 2019 Oct 11;10:2426 (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0242)
Rhesus macaques (Macaca mulatta) are used as a human-relevant animal species for the evaluation of vaccines and as a source for cloning monoclonal antibodies (mAbs) that are highly similar to human-derived ...
Li J, Zhang K, Fan W, Zhang S, Li Y, Gu J, Zhou J,. Transcriptome Profiling Reveals Differential Effect of Interleukin-17A Upon Influenza Virus Infection in Human Cells. Front Microbiol. 2019 Oct 10;10:2344.. Abstract
submitted by kickingbird at Nov, 7, 2019 from Front Microbiol. 2019 Oct 10;10:2344. (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0234)
Influenza A virus (IAV) has developed elegant strategies to utilize cellular proteins and pathways to promote replication and evade the host antiviral response. Identification of these sabotaged host factors ...
Sakai-Tagawa Y, Yamayoshi S, Kawaoka Y. Sensitivity of Commercially Available Influenza Rapid Diagnostic Tests in the 2018-2019 Influenza Season. Front Microbiol. 2019 Oct 11;10:2342.. Abstract
submitted by kickingbird at Nov, 7, 2019 from Front Microbiol. 2019 Oct 11;10:2342. (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0234)
Epidemics of seasonal influenza caused by H1N1pdm09, H3N2, and type B viruses occur throughout the world. Sporadic human H5 and H7N9 virus infections are also reported in particular regions. To treat influenza ...
Yang J, Li H, Jia L, Lan X, Zhao Y, Bian H, Li Z. High expression levels of influenza virus receptors in airway of the HBV-transgenic mice. Epidemiol Infect. 2019 Nov 4;147:e297.. Abstract
submitted by kickingbird at Nov, 7, 2019 from Epidemiol Infect. 2019 Nov 4;147:e297. (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
In the human population, influenza A viruses are associated with acute respiratory illness and are responsible for millions of deaths annually. Avian and human influenza viruses typically have a different ...
Ampomah PB, Lim LHK. Influenza A virus-induced apoptosis and virus propagation. Apoptosis. 2019 Oct 30. Abstract
submitted by kickingbird at Nov, 3, 2019 from Apoptosis. 2019 Oct 30 (via https://www.ncbi.nlm.nih.gov/pubmed/31667646)
Influenza A viruses (IAVs) are respiratory pathogens that cause severe morbidity and mortality worldwide. They affect cellular processes such as proliferation, protein synthesis, autophagy, and apoptosis. ...
Uyeki TM, Peiris M. Novel Avian Influenza A Virus Infections of Humans. Infect Dis Clin North Am. 2019 Dec;33(4):907-932.. Abstract
submitted by kickingbird at Nov, 3, 2019 from Infect Dis Clin North Am. 2019 Dec;33(4):907-932. (via https://www.ncbi.nlm.nih.gov/pubmed/31668198)
A high index of suspicion and early diagnosis of avian influenza A virus infection is essential reduce transmission risk. Clinical suspicion relies on eliciting a history of recent exposure to poultry ...
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