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2025-12-19 2:52:51
Article

Schughart K, Smith AM, Tsalik EL, Threlkeld SC, Se. Host response to influenza infections in human blood: association of influenza severity with host genetics and transcriptomic response. Front Immunol. 2024 Aug 13;15:1385362.  Abstract  
submitted by kickingbird at Aug, 28, 2024 from Front Immunol. 2024 Aug 13;15:1385362 (via https://www.frontiersin.org/journals/immunology/articles/10.)
Introduction: Influenza virus infections are a major global health problem. Influenza can result in mild/moderate disease or progress to more severe disease, leading to high morbidity and mortality. Severity ...

Kutkat O, Gomaa M, Moatasim Y, Taweel AE, Kamel MN. Highly Pathogenic Avian Influenza Virus H5N1 clade 2.3.4.4b in Wild Rats in Egypt during 2023. Emerg Microbes Infect. 2024 Aug 28:2396874.  Abstract  
submitted by kickingbird at Aug, 28, 2024 from Emerg Microbes Infect. 2024 Aug 28:2396874 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
Avian influenza viruses (AIVs) pose continuous challenges to human and animal health worldwide. Wild birds are considered the natural reservoir for AIVs and play a major role in spreading influenza viruses ...

Zhao X, Gu Y, Tang X, Jiang C, Fang F, Chu W, Tao. Whole-genome analysis of circulating influenza A virus (H3N2) strains in Shanghai, China from 2005 to 2023. Emerg Microbes Infect. 2024 Aug 28:2396867.  Abstract  
submitted by kickingbird at Aug, 28, 2024 from Emerg Microbes Infect. 2024 Aug 28:2396867 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
Seasonal influenza A virus subtype H3N2 (A/H3N2) circulates globally and has been linked to higher hospitalization rates and summer outbreaks in temperate regions. Here, A/H3N2 circulation in Shanghai, ...

Zhang X, Wu J, Wang Y, Hao M, Liu H, Fan S, et al. Highly Pathogenic Avian Influenza A Virus in Wild Migratory Birds, Qinghai Lake, China, 2022. Emerg Infect Dis. 2024 Oct.  Abstract  
submitted by kickingbird at Aug, 28, 2024 from Emerg Infect Dis. 2024 Oct (via https://wwwnc.cdc.gov/eid/article/30/10/24-0460_article)
In July 2022, an outbreak of highly pathogenic avian influenza A(H5N1) virus clade 2.3.4.4b occurred among migratory birds at Qinghai Lake in China. The virus circulated in June, and reassortants emerged ...

Din GU, Wu C, Tariq Z, Hasham K, Amjad MN, Shen B,. Unlocking influenza B: exploring molecular biology and reverse genetics for epidemic control and vaccine innovation. Virol J. 2024 Aug 23;21(1):196.  Abstract  
submitted by kickingbird at Aug, 27, 2024 from Virol J. 2024 Aug 23;21(1):196 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Influenza is a highly contagious acute viral illness that affects the respiratory system, posing a significant global public health concern. Influenza B virus (IBV) causes annual seasonal epidemics. The ...

Gao Y, Guyatt G, Uyeki TM, Liu M, Chen Y, Zhao Y,. Antivirals for treatment of severe influenza: a systematic review and network meta-analysis of randomised controlled trials. Lancet. 2024 Aug 24;404(10454):753-763.  Abstract  
submitted by kickingbird at Aug, 27, 2024 from Lancet. 2024 Aug 24;404(10454):753-763 (via https://www.thelancet.com/journals/lancet/article/PIIS0140-6)
Background: The optimal antiviral drug for treatment of severe influenza remains unclear. To support updated WHO influenza clinical guidelines, this systematic review and network meta-analysis evaluated ...

Zhao Y, Gao Y, Guyatt G, Uyeki TM, Liu P, Liu M, S. Antivirals for post-exposure prophylaxis of influenza: a systematic review and network meta-analysis. Lancet. 2024 Aug 24;404(10454):764-772.  Abstract  
submitted by kickingbird at Aug, 27, 2024 from Lancet. 2024 Aug 24;404(10454):764-772 (via https://www.thelancet.com/journals/lancet/article/PIIS0140-6)
Background: Antiviral post-exposure prophylaxis with neuraminidase inhibitors can reduce the incidence of influenza and the risk of symptomatic influenza, but the efficacy of the other classes of antiviral ...

Committee on Infectious Diseases. Recommendations for Prevention and Control of Influenza in Children, 2024-2025: Technical Report. Pediatrics. 2024 Aug 26:e2024068508.  Abstract  
submitted by kickingbird at Aug, 27, 2024 from Pediatrics. 2024 Aug 26:e2024068508 (via https://publications.aap.org/pediatrics/article/doi/10.1542/)
This technical report accompanies the recommendations of the American Academy of Pediatrics for the routine use of influenza vaccine and antiviral medications in the prevention and treatment of influenza ...

Committee on Infectious Diseases. Recommendations for Prevention and Control of Influenza in Children, 2024-2025: Policy Statement. Pediatrics. 2024 Aug 26:e2024068507.  Abstract  
submitted by kickingbird at Aug, 27, 2024 from Pediatrics. 2024 Aug 26:e2024068507 (via https://publications.aap.org/pediatrics/article/doi/10.1542/)
The American Academy of Pediatrics recommends annual influenza vaccination of all children without medical contraindications starting at 6 months of age. Children are at risk for hospitalization and death ...

Kelsey M. Rayment, etc.,al. [preprint]Exposure and Survival of Wild Raptors During the 2022-2023 Highly Pathogenic Influenza A Virus Outbreak. https://doi.org/10.21203/rs.3.rs-4759859/v1.  Abstract  
submitted by kickingbird at Aug, 27, 2024 from https://doi.org/10.21203/rs.3.rs-4759859/v1 (via https://www.researchsquare.com/article/rs-4759859/v1)
The global outbreak of clade 2.3.4.4b H5N1 highly pathogenic influenza A virus (HP H5N1) has had an unprecedented impact on wild birds including raptors, but long-term population impacts have not been ...

David Hawman, etc.,al. [preprint]Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge. https://doi.org/10.21203/rs.3.rs-4946897/v1.  Abstract  
submitted by kickingbird at Aug, 27, 2024 from https://doi.org/10.21203/rs.3.rs-4946897/v1 (via https://www.researchsquare.com/article/rs-4946897/v1)
The ongoing circulation of influenza A H5N1 in the United States has raised concerns of a pandemic caused by highly pathogenic avian influenza. Although the United States has stockpiled and is prepared ...

Luise Hohensee, etc.,al. PB1-F2 of low pathogenicity H7N7 restricts apoptosis in avian cells. Virus Research, Volume 349 , November 2024.  Abstract  
submitted by kickingbird at Aug, 25, 2024 from Virus Research, Volume 349 , November 2024 (via https://www.sciencedirect.com/science/article/pii/S016817022)
Avian influenza viruses (AIV) pose a continuous challenge to global health and economy. While countermeasures exist to control outbreaks in poultry, the persistent circulation of AIV in wild aquatic and ...

Li Y, Yin Z, Wang J, Xu Y, Huo S, Wu Y, Dou D, Han. Surveillance of avian influenza viruses in Hebei Province of China from 2021 to 2023: identification of a novel reassortant H3N3. J Infect. 2024 Aug 20:106240.  Abstract  
submitted by kickingbird at Aug, 24, 2024 from J Infect. 2024 Aug 20:106240 (via https://www.journalofinfection.com/article/S0163-4453(24)001)
Avian influenza remains a global public health concern for its well-known point mutation and genomic segment reassortment, through which plenty of serum serotypes are generated to escape existing immune ...

Liping Wang, etc.,al. Incompatible packaging signals and impaired protein functions hinder reassortment of bat H17N10 or H18N11 segment 7 with human H1N1 influenza A viruses. Journal of Virology, 20 August 2024.  Abstract  
submitted by kickingbird at Aug, 21, 2024 from Journal of Virology, 20 August 2024 (via https://journals.asm.org/doi/10.1128/jvi.00864-24)
Novel bat H17N10 and H18N11 influenza A viruses (IAVs) are incapable of reassortment with conventional IAVs during co-infection. To date, the underlying mechanisms that inhibit bat and conventional IAV ...

Sougat Misra, etc.,al. [preprint]Enhanced Diversifying Selection on Polymerase Genes in H5N1 Clade 2.3.4.4b: A Key Driver of Altered Species Tropism and Host Range Expansion. https://doi.org/10.1101/2024.08.19.606826.  Abstract  
submitted by kickingbird at Aug, 21, 2024 from https://doi.org/10.1101/2024.08.19.606826 (via https://www.biorxiv.org/content/10.1101/2024.08.19.606826v1)
Highly pathogenic avian influenza H5N1 clade 2.3.4.4b viruses have shown unprecedented host range and pathogenicity, including infections in cattle, previously not susceptible to H5N1.We investigated whether ...

Thomas Tipih, etc.,al. [preprint]Recent Bovine HPAI H5N1 Isolate is Highly Virulent for Mice, Rapidly Causing Acute Pulmonary and Neurologic Disease. https://doi.org/10.1101/2024.08.19.608652.  Abstract  
submitted by kickingbird at Aug, 21, 2024 from https://doi.org/10.1101/2024.08.19.608652 (via https://www.biorxiv.org/content/10.1101/2024.08.19.608652v1)
The highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b viruses, responsible for the current outbreak in dairy cows in the United States, pose a significant animal and public health threat. ...

Ke Zhai, etc.,al. Global antigenic landscape and vaccine recommendation strategy for low pathogenic avian influenza A (H9N2) viruses. Journal of Infection Vol. 89 Issue 2.  Abstract  
submitted by kickingbird at Aug, 20, 2024 from Journal of Infection Vol. 89 Issue 2 (via https://www.journalofinfection.com/article/S0163-4453(24)001)
The sustained circulation of H9N2 avian influenza viruses (AIVs) poses a significant threat for contributing to a new pandemic. Given the temporal and spatial uncertainty in the antigenicity of H9N2 AIVs, ...

Alexander Helmut Rotsch, etc.,al. [preprint]Mechanism of Co-Transcriptional Cap-Snatching by Influenza Polymerase. https://doi.org/10.1101/2024.08.11.607481.  Abstract  
submitted by kickingbird at Aug, 20, 2024 from https://doi.org/10.1101/2024.08.11.607481 (via https://www.biorxiv.org/content/10.1101/2024.08.11.607481v1)
Influenza virus mRNA is stable and competent for nuclear export and translation because it receives a 5′ cap(1) structure in a process called cap-snatching1. During cap-snatching, the viral RNA-dependent ...

Yu H, Sun Y, Zhang J, Zhang W, Liu W, Liu P, Liu K. Influenza A virus infection activates caspase-8 to enhance innate antiviral immunity by cleaving CYLD and blocking TAK1 and RIG-I deubiquitination. Cell Mol Life Sci. 2024 Aug 19;81(1):355.  Abstract  
submitted by kickingbird at Aug, 20, 2024 from Cell Mol Life Sci. 2024 Aug 19;81(1):355 (via https://link.springer.com/article/10.1007/s00018-024-05392-z)
Caspase-8, an aspartate-specific cysteine protease that primarily functions as an initiator caspase to induce apoptosis, can downregulate innate immunity in part by cleaving RIPK1 and IRF3. However, patients ...

Spackman E, Anderson N, Walker S, Suarez DL, Jones. Inactivation of highly pathogenic avian influenza virus with high temperature short time continuous flow pasteurization and virus detection in bulk milk tanks. J Food Prot. 2024 Aug 16:100349.  Abstract  
submitted by kickingbird at Aug, 20, 2024 from J Food Prot. 2024 Aug 16:100349 (via https://pubmed.ncbi.nlm.nih.gov/39154916/)
Infections of dairy cattle with clade 2.3.4.4b H5N1 highly pathogenic avian influenza virus (HPAIV) were reported in March 2024 in the U.S. and viable virus was detected at high levels in raw milk from ...

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