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2020-1-23 22:29:02
Article

Khalaj-Hedayati A, Chua CLL, Smooker P, Lee KW. Nanoparticles in influenza subunit vaccine development: Immunogenicity enhancement. Influenza Other Respir Viruses. 2019 Nov 27.  Abstract  
submitted by kickingbird at Dec, 1, 2019 from Influenza Other Respir Viruses. 2019 Nov 27 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12697)
The threat of novel influenza infections has sparked research efforts to develop subunit vaccines that can induce a more broadly protective immunity by targeting selected regions of the virus. In general, ...

Hanpaibool C, et al. Source of oseltamivir resistance due to single E119D and double E119D/H274Y mutations in pdm09H1N1 influenza neuraminidase. J Comput Aided Mol Des. 2019 Nov 26.  Abstract  
submitted by kickingbird at Dec, 1, 2019 from J Comput Aided Mol Des. 2019 Nov 26 (via https://www.ncbi.nlm.nih.gov/pubmed/31773463)
Influenza epidemics are responsible for an average of 3-5 millions of severe cases and up to 500,000 deaths around the world. One of flu pandemic types is influenza A(H1N1)pdm09 virus (pdm09H1N1). Oseltamivir ...

Haller O, Kochs G. Mx genes: host determinants controlling influenza virus infection and trans-species transmission. Hum Genet. 2019 Nov 26..  Abstract  
submitted by kickingbird at Dec, 1, 2019 from Hum Genet. 2019 Nov 26. (via https://www.ncbi.nlm.nih.gov/pubmed/31773252)
The human MxA protein, encoded by the interferon-inducible MX1 gene, is an intracellular influenza A virus (IAV) restriction factor. It can protect transgenic mice from severe IAV-induced disease, indicating ...

Wang Y, Song T, Li K, Jin Y, Yue J, Ren H, Liang L. Different Subtypes of Influenza Viruses Target Different Human Proteins and Pathways Leading to Different Pathogenic Phenotypes. Biomed Res Int. 2019 Oct 22;2019:4794910.  Abstract  
submitted by kickingbird at Dec, 1, 2019 from Biomed Res Int. 2019 Oct 22;2019:4794910 (via https://www.hindawi.com/journals/bmri/2019/4794910/)
Different subtypes of influenza A viruses (IAVs) cause different pathogenic phenotypes after infecting human bodies. Analysis of the interactions between viral proteins and the host proteins may provide ...

Park YR, et al. Genetic and pathogenic characteristics of clade 2.3.2.1c H5N1 highly pathogenic avian influenza viruses isolated from poultry outbreaks in Laos during 2015-2018. Transbound Emerg Dis. 2019 Nov 26..  Abstract  
submitted by kickingbird at Nov, 28, 2019 from Transbound Emerg Dis. 2019 Nov 26. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13430)
Since 2004, there have been multiple outbreaks of H5 highly pathogenic avian influenza (HPAI) viruses in Laos. Here, we isolated H5N1 HPAI viruses from poultry outbreaks in Laos during 2015-2018 and investigated ...

Putri L, et al. Co-circulation and characterization of HPAI-H5N1 and LPAI-H9N2 recovered from a duck farm, Yogyakarta, Indonesia. Transbound Emerg Dis. 2019 Nov 26..  Abstract  
submitted by kickingbird at Nov, 28, 2019 from Transbound Emerg Dis. 2019 Nov 26. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13434)
In July 2016, an avian influenza outbreak in duck farms in Yogyakarta province was reported to Disease Investigation Center (DIC) Wates, Indonesia with approximately 1,000 ducks death or culled. In this ...

Shin DL, et al. Highly Pathogenic Avian Influenza A(H5N8) Virus in Gray Seals, Baltic Sea. Emerg Infect Dis. 2019 Dec;25(12):2295-2298.  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Emerg Infect Dis. 2019 Dec;25(12):2295-2298 (via https://wwwnc.cdc.gov/eid/article/25/12/18-1472_article)
We detected a highly pathogenic avian influenza A(H5N8) virus in lung samples of 2 gray seals (Halichoerus grypus) stranded on the Baltic coast of Poland in 2016 and 2017. This virus, clade 2.3.4.4 B, ...

Martelli P, et al. Influenza A(H1N1)pdm09 Virus Infection in a Captive Giant Panda, Hong Kong. Emerg Infect Dis. 2019 Dec;25(12):2303-2306..  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Emerg Infect Dis. 2019 Dec;25(12):2303-2306. (via https://wwwnc.cdc.gov/eid/article/25/12/19-1143_article)
We report influenza A(H1N1)pdm09 virus infection in a captive giant panda in Hong Kong. The viral load peaked on day 1 and became undetectable on day 5, and an antibody response developed. Genome analysis ...

Fusade-Boyer M, et al. Evolution of Highly Pathogenic Avian Influenza A(H5N1) Virus in Poultry, Togo, 2018. Emerg Infect Dis. 2019 Dec;25(12):2287-2289.  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Emerg Infect Dis. 2019 Dec;25(12):2287-2289 (via https://wwwnc.cdc.gov/eid/article/25/12/19-0054_article)
In 2015, highly pathogenic avian influenza A(H5N1) viruses reemerged in poultry in West Africa. We describe the introduction of a reassortant clade 2.3.2.1c virus into Togo in April 2018. Our findings ...

Susloparov IM, et al. Genetic Characterization of Avian Influenza A(H5N6) Virus Clade 2.3.4.4, Russia, 2018. Emerg Infect Dis. 2019 Dec;25(12):2338-2339..  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Emerg Infect Dis. 2019 Dec;25(12):2338-2339. (via https://wwwnc.cdc.gov/eid/article/25/12/19-0504_article)
Timely identification of pandemic influenza threats depends on monitoring for highly pathogenic avian influenza viruses. We isolated highly pathogenic avian influenza A(H5N6) virus clade 2.3.4.4, genotype ...

Evseenko VA, et al. Comparative thermostability analysis of zoonotic and human influenza virus A and B neuraminidase. Arch Virol. 2019 Nov 19..  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Arch Virol. 2019 Nov 19. (via https://www.ncbi.nlm.nih.gov/pubmed/31745716)
Neuraminidase (NA) thermostability of influenza A and B viruses isolated from birds, swine and humans was measured to evaluate its variability associated with host body temperature. The highest 50% inactivation ...

Xu Y, et al. Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin. Cell Rep. 2019 Nov 19;29(8):2217-2228.e5..  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Cell Rep. 2019 Nov 19;29(8):2217-2228.e5. (via https://www.ncbi.nlm.nih.gov/pubmed/31747596)
Since 2013, H7N9 avian influenza viruses (AIVs) have caused more than 1,600 human infections, posing a threat to public health. An emerging concern is whether H7N9 AIVs will cause pandemics among humans. ...

Fusaro A, et al. Disentangling the role of Africa in the global spread of H5 highly pathogenic avian influenza. Nat Commun. 2019 Nov 22;10(1):5310..  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Nat Commun. 2019 Nov 22;10(1):5310. (via https://www.ncbi.nlm.nih.gov/pubmed/31757953)
The role of Africa in the dynamics of the global spread of a zoonotic and economically-important virus, such as the highly pathogenic avian influenza (HPAI) H5Nx of the Gs/GD lineage, remains unexplored. ...

Gilchuk IM, et al. Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice. Cell Host Microbe. 2019 Nov 1..  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Cell Host Microbe. 2019 Nov 1. (via https://www.ncbi.nlm.nih.gov/pubmed/31757769)
H7N9 avian influenza virus causes severe infections and might have the potential to trigger a major pandemic. Molecular determinants of human humoral immune response to N9 neuraminidase (NA) proteins, ...

Zhu X, et al. Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. Cell Host Microbe. 2019 Oct 24.  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Cell Host Microbe. 2019 Oct 24 (via https://www.ncbi.nlm.nih.gov/pubmed/31757767)
Influenza virus neuraminidase (NA) is a major target for small-molecule antiviral drugs. Antibodies targeting the NA surface antigen could also inhibit virus entry and egress to provide host protection. ...

Chen G, et al. A double-stranded RNA platform is required for the interaction between a host restriction factor and the NS1 protein of influenza A virus. Nucleic Acids Res. 2019 Nov 22..  Abstract  
submitted by kickingbird at Nov, 25, 2019 from Nucleic Acids Res. 2019 Nov 22. (via https://academic.oup.com/nar/advance-article/doi/10.1093/nar)
Influenza A viruses cause widespread human respiratory disease. The viral multifunctional NS1 protein inhibits host antiviral responses. This inhibition results from the binding of specific cellular antiviral ...

Wang J, Wiltse A, Zand MS. A Complex Dance: Measuring the Multidimensional Worlds of Influenza Virus Evolution and Anti-Influenza Immune Responses. Pathogens. 2019 Nov 15;8(4).  Abstract  
submitted by kickingbird at Nov, 18, 2019 from Pathogens. 2019 Nov 15;8(4) (via https://www.mdpi.com/2076-0817/8/4/238)
The human antibody response to influenza virus infection or vaccination is as complicated as it is essential for protection against flu. The constant antigenic changes of the virus to escape human herd ...

Londrigan SL, et al. IFITM3 and type I interferons are important for the control of influenza A virus replication in murine macrophages. Virology. 2019 Nov 5;540:17-22..  Abstract  
submitted by kickingbird at Nov, 18, 2019 from Virology. 2019 Nov 5;540:17-22. (via https://www.ncbi.nlm.nih.gov/pubmed/31731106)
Abortive infection of macrophages serves as a "dead end" for most seasonal influenza A virus (IAV) strains, and it is likely to contribute to effective host defence. Interferon (IFN)-induced transmembrane ...

Harding AT, Haas GD, Chambers BS, Heaton NS. Influenza viruses that require 10 genomic segments as antiviral therapeutics. PLoS Pathog. 2019 Nov 15;15(11):e1008098..  Abstract  
submitted by kickingbird at Nov, 18, 2019 from PLoS Pathog. 2019 Nov 15;15(11):e1008098. (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A viruses (IAVs) encode their genome across eight, negative sense RNA segments. During viral assembly, the failure to package all eight segments, or packaging a mutated segment, renders the resulting ...

Li R, Zhang T, Xu J, Chang J, Xu B. Novel Reassortant Avian Influenza A(H3N8) Virus Isolated from a Wild Bird in Jiangxi, China. Microbiol Resour Announc. 2019 Nov 14;8(46)..  Abstract  
submitted by kickingbird at Nov, 18, 2019 from Microbiol Resour Announc. 2019 Nov 14;8(46). (via https://mra.asm.org/content/8/46/e01163-19)
Here, we report the detection of a reassortant avian influenza A(H3N8) virus isolated from a wild bird in Poyang Lake, Jiangxi, China, in 2014. Phylogenetic analyses indicated that this virus is most likely ...

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