Wei X, Cui J. Why were so few people infected with H7N9 influenza A viruses in China from late 2017 to 2018?. Sci China Life Sci. 2018 Oct 23. Abstract
submitted by kickingbird at Oct, 30, 2018 from Sci China Life Sci. 2018 Oct 23 (via https://link.springer.com/article/10.1007%2Fs11427-018-9406-)
Since the first human infection case with H7N9 avian influenzavirus(AIVs)wasidentifiedinMarch2013,therehas six viral outbreak waves recorded in China as of September 2018. In total, there have been 1,567 ...
Yegani S, Shoushtari AH, Eshratabadi F, Molouki A. Full sequence analysis of hemagglutinin and neuraminidase genes and proteins of highly pathogenic avian influenza H5N1 virus detected in Iran, 2015. Trop Anim Health Prod. 2018 Oct 27.. Abstract
submitted by kickingbird at Oct, 29, 2018 from Trop Anim Health Prod. 2018 Oct 27. (via https://www.ncbi.nlm.nih.gov/pubmed/30368763)
Over the last two decades, the highly pathogenic avian influenza H5N1 virus has gained a lot of attention due to its zoonotic and mutative nature. Iran is among the countries significantly affected by ...
Deka H, Nath D, Uddin A, Chakraborty S. DNA compositional dynamics and codon usage patterns of M1 and M2 matrix protein genes in influenza A virus. Infect Genet Evol. 2018 Oct 24.. Abstract
submitted by kickingbird at Oct, 29, 2018 from Infect Genet Evol. 2018 Oct 24. (via https://www.ncbi.nlm.nih.gov/pubmed/30367980)
Influenza A virus subtype H3N2 has been a serious health issue across the globe with approximately 36 thousand annual casualties in the United States of America only. Co-circulation in avian, swine and ...
Fukuta H, Goto T, Wakami K, Kamiya T, Ohte N. The effect of influenza vaccination on mortality and hospitalization in patients with heart failure: a systematic review and meta-analysis. Heart Fail Rev. 2018 Oct 26.. Abstract
submitted by kickingbird at Oct, 29, 2018 from Heart Fail Rev. 2018 Oct 26. (via https://www.ncbi.nlm.nih.gov/pubmed/30367316)
Influenza infection is associated with increased risk for mortality and hospitalization in heart failure patients. Although there are no published randomized controlled trials examining the effect of influenza ...
Harland KL, et al. Limited Phenotypic and Functional Plasticity of Influenza Virus-Specific Memory CD8+ T Cells during Activation in an Alternative Cytokine Environment. J Immunol. 2018 Oct 26. Abstract
submitted by kickingbird at Oct, 29, 2018 from J Immunol. 2018 Oct 26 (via https://www.ncbi.nlm.nih.gov/pubmed/30366957)
Naive CD8+ T cells show phenotypic, functional, and epigenetic plasticity, enabling differentiation into distinct cellular states. However, whether memory CD8+ T cells demonstrate similar flexibility upon ...
Korenkov D, Isakova-Sivak I, Rudenko L. Basics of CD8 T-cell immune responses after influenza infection and vaccination with inactivated or live attenuated influenza vaccine. Expert Rev Vaccines. 2018 Oct 26. Abstract
submitted by kickingbird at Oct, 29, 2018 from Expert Rev Vaccines. 2018 Oct 26 (via https://www.ncbi.nlm.nih.gov/pubmed/30365908)
Numerous effector reactions are involved in antiviral immunity. The antibody and T-cell-mediated reactions are the best-understood processes of the adaptive immune response against influenza virus. One ...
Pu Z, Luo T, Yang J, Shen X, Irwin DM, et al. Rapid evolving H7N9 avian influenza A viruses pose new challenge. J Infect. 2018 Oct 24. Abstract
submitted by kickingbird at Oct, 29, 2018 from J Infect. 2018 Oct 24 (via https://www.journalofinfection.com/article/S0163-4453(18)303)
Recently, the hemagglutinin characteristics, pathogenicity, and antigenic variation of highly pathogenic (HP) H7N9 avian influenza viruses (AIVs) were reported in this journal.1 H7N9 AIVs have been endemic ...
Li J, et al. Protective efficacy of an inactivated chimeric H5 avian influenza vaccine against H5 highly pathogenic avian influenza virus clades 22.214.171.124 and 126.96.36.199. J Gen Virol. 2018 Oct 25. Abstract
submitted by kickingbird at Oct, 27, 2018 from J Gen Virol. 2018 Oct 25 (via https://www.ncbi.nlm.nih.gov/pubmed/30358528)
The H5 subtype of highly pathogenic avian influenza (HPAI) viruses pose a serious challenge to public health and the poultry industry in China. In this study, we generated a chimeric QH/KJ recombinant ...
Kim TH, Zhou H. Overexpression of Chicken IRF7 Increased Viral Replication and Programmed Cell Death to the Avian Influenza Virus Infection Through TGF-Beta/FoxO Signaling Axis in DF-1. Front Genet. 2018 Sep 25;9:415. Abstract
submitted by kickingbird at Oct, 27, 2018 from Front Genet. 2018 Sep 25;9:415 (via https://www.ncbi.nlm.nih.gov/pubmed/30356848)
During mammalian viral infections, interferon regulatory factor 7 (IRF7) partners with IRF3 to regulate the type I interferon response. In chickens, however, it is still unclear how IRF7 functions in the ...
An Y, Parsons LM, Jankowska E, Melnyk D, et al. N-Glycosylation of Seasonal Influenza Vaccine Hemagglutinins: Implication for potency testing and immune processing. J Virol. 2018 Oct 24.. Abstract
submitted by kickingbird at Oct, 27, 2018 from J Virol. 2018 Oct 24. (via https://www.ncbi.nlm.nih.gov/pubmed/30355697)
Prior to each annual flu season, health authorities recommend three or four virus strains for inclusion in the annual influenza vaccine: a Type A:H1N1, a Type A:H3N2, and one or two Type B viruses. Antigenic ...
Dornfeld D, et al. Eurasian avian-like swine influenza A viruses escape human MxA restriction by distinct mutations in their nucleoprotein. J Virol. 2018 Oct 24.. Abstract
submitted by kickingbird at Oct, 27, 2018 from J Virol. 2018 Oct 24. (via https://www.ncbi.nlm.nih.gov/pubmed/30355693)
To cross the human species barrier, influenza A viruses (IAV) of avian origin have to overcome the interferon-induced host restriction factor MxA by acquiring distinct mutations in their nucleoprotein ...
Gaba A, Xu F, Lu Y, Park HS, Liu G, Zhou Y. THE NS1 PROTEIN OF INFLUENZA A VIRUS PARTICIPATES IN NECROPTOSIS BY INTERACTING WITH MLKL AND INCREASING ITS OLIGOMERIZATION AND MEMBRANE TRANSLOCATION. J Virol. 2018 Oct 24. Abstract
submitted by kickingbird at Oct, 27, 2018 from J Virol. 2018 Oct 24 (via https://jvi.asm.org/content/early/2018/10/19/JVI.01835-18.lo)
Elimination of infected cells by programmed cell death is a well-recognized host defense mechanism to control the spread of infection. In addition to apoptosis, necroptosis is also one of the mechanisms ...
Santos JJS, et al. Plasticity of amino acid residue 145 near the receptor binding site of H3 swine influenza A viruses and its impact on receptor binding and antibody recognition. J Virol. 2018 Oct 24. Abstract
submitted by kickingbird at Oct, 27, 2018 from J Virol. 2018 Oct 24 (via https://www.ncbi.nlm.nih.gov/pubmed/30355680)
The hemagglutinin (HA), a glycoprotein on the surface of influenza A virus (IAV), initiates the virus life cycle by binding to terminal sialic acid (SA) residues on host cells. The HA gradually accumulates ...
Wu J, Ke C, Lau EHY, Song Y, Cheng KL, Zou L, et a. Influenza H5/H7 Virus Vaccination in Poultry and Reduction of Zoonotic Infections, Guangdong Province, China, 2017~18. Emerg Infect Dis. 2019 Jan. Abstract
submitted by kickingbird at Oct, 27, 2018 from Emerg Infect Dis. 2019 Jan (via https://wwwnc.cdc.gov/eid/article/25/1/18-1259_article)
We compared the detection frequency of avian influenza H7 subtypes at live poultry markets in Guangdong Province, China, before and after the introduction of a bivalent H5/H7 vaccine in poultry. The vaccine ...
Hird SM, Ganz H, Eisen JA, Boyce WM. The Cloacal Microbiome of Five Wild Duck Species Varies by Species and Influenza A Virus Infection Status. mSphere. 2018 Oct 24;3(5).. Abstract
submitted by kickingbird at Oct, 27, 2018 from mSphere. 2018 Oct 24;3(5). (via https://www.ncbi.nlm.nih.gov/pubmed/30355662)
Waterfowl, especially ducks of the genus Anas, are natural reservoir species for influenza A virus (IAV). Duck populations contain nearly all the known diversity of IAVs, and the birds are asymptomatic ...
Wu H, Yang F, Liu F, Lu R, Peng X, Chen B, Yao H. Isolation and characterization of novel reassortant H6N1 avian influenza viruses from chickens in Eastern China. Virol J. 2018 Oct 24;15(1):164.. Abstract
submitted by kickingbird at Oct, 27, 2018 from Virol J. 2018 Oct 24;15(1):164. (via https://www.ncbi.nlm.nih.gov/pubmed/30355336)
BACKGROUND: The H6N1 subtype of avian influenza viruses (AIVs) can infect people with an influenza-like illness; the H6N1 viruses possess the ability for zoonotic transmission from avians into mammals, ...
Wei D, et al. Genome-wide characterization of the seasonal H3N2 virus in Shanghai reveals natural temperature-sensitive strains conferred by the I668V mutation in the PA subunit. Emerg Microbes Infect. 2018 Oct 23;7(1):171. Abstract
submitted by kickingbird at Oct, 27, 2018 from Emerg Microbes Infect. 2018 Oct 23;7(1):171 (via https://www.ncbi.nlm.nih.gov/pubmed/30353004)
Seasonal H3N2 influenza viruses are recognized as major epidemic viruses, exhibiting complex seasonal patterns in regions with temperate climates. To investigate the influence of viral evolution and mutations ...
Bedi S, Noda T, Kawaoka Y, Ono A. A Defect in Influenza A Virus Particle Assembly Specific to Primary Human Macrophages. MBio. 2018 Oct 23;9(5). Abstract
submitted by kickingbird at Oct, 27, 2018 from MBio. 2018 Oct 23;9(5) (via https://www.ncbi.nlm.nih.gov/pubmed/30352935)
Influenza A virus (IAV) propagates efficiently in epithelial cells, its primary target in the respiratory tract. In contrast, productive infection of most IAV strains is either blocked or highly inefficient ...
Goldhill DH, et al. The mechanism of resistance to favipiravir in influenza. Proc Natl Acad Sci U S A. 2018 Oct 23.. Abstract
submitted by kickingbird at Oct, 27, 2018 from Proc Natl Acad Sci U S A. 2018 Oct 23. (via https://www.ncbi.nlm.nih.gov/pubmed/30352857)
Favipiravir is a broad-spectrum antiviral that has shown promise in treatment of influenza virus infections. While emergence of resistance has been observed for many antiinfluenza drugs, to date, clinical ...
Euro Surveill. 2018;23(43):pii=1700732. Influenza vaccine effectiveness in reducing severe outcomes over six influenza seasons, a case-case analysis, Spain, 2010/11 to 2015/16. Godoy Pere, Romero Arantxa, Soldevila Núria, Torn. Abstract
submitted by kickingbird at Oct, 26, 2018 from Godoy Pere, Romero Arantxa, Soldevila Núria, Torn (via https://www.eurosurveillance.org/content/10.2807/1560-7917.E)
Introduction When influenza vaccination is ineffective in preventing influenza virus infection, it may still reduce the severity of influenza-associated disease. Here, we estimate the effect of influenza ...
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