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2020-9-21 17:44:14
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Hu Z, Shi L, Xu N, et al. Induction of Cross-Group Broadly Reactive Antibody Response by Natural H7N9 Avian Influenza Virus Infection and Immunization With Inactivated H7N9 Vaccine in Chickens. Transbound Emerg Dis. 2020;10.1111/tbed.13705.  Abstract  
submitted by kickingbird at Jul, 2, 2020 from Transbound Emerg Dis. 2020;10.1111/tbed.13705 (via https://pubmed.ncbi.nlm.nih.gov/32602258/)
Pre-existing immunity against the conserved hemagglutinin (HA) stalk underlies the elicitation of cross-group antibody induced by natural H7N9 virus infection and immunization in humans. However, whether ...

Park JK, Xiao Y, Ramuta MD, et al. Pre-existing Immunity to Influenza Virus Hemagglutinin Stalk Might Drive Selection for Antibody-Escape Mutant Viruses in a Human Challenge Model. Nat Med. 2020;10.1038/s41591-020-0937-x.  Abstract  
submitted by kickingbird at Jul, 2, 2020 from Nat Med. 2020;10.1038/s41591-020-0937-x (via https://pubmed.ncbi.nlm.nih.gov/32601336/)
The conserved region of influenza hemagglutinin (HA) stalk (or stem) has gained attention as a potent target for universal influenza vaccines1-5. Although the HA stalk region is relatively well conserved, ...

Le Sage V, Kanarek JP, Snyder DJ, Cooper VS, Lakda. Mapping of Influenza Virus RNA-RNA Interactions Reveals a Flexible Network. Cell Rep. 2020;31(13):107823.  Abstract  
submitted by kickingbird at Jul, 2, 2020 from Cell Rep. 2020;31(13):107823 (via https://pubmed.ncbi.nlm.nih.gov/32610124/)
Selective assembly of influenza virus segments into virions is proposed to be mediated through intersegmental RNA-RNA interactions. Here, we developed a method called 2CIMPL that includes proximity ligation ...

Ruan T, Sun J, Liu W, et al. H1N1 Influenza Virus Cross-Activates Gli1 to Disrupt the Intercellular Junctions of Alveolar Epithelial Cells. Cell Rep. 2020;31(13):107801.  Abstract  
submitted by kickingbird at Jul, 2, 2020 from Cell Rep. 2020;31(13):107801
Influenza A virus (IAV) primarily infects the airway and alveolar epithelial cells and disrupts the intercellular junctions, leading to increased paracellular permeability. Although this pathological change ...

Sevy AM, Gilchuk IM, Brown BP, et al. Computationally Designed Cyclic Peptides Derived From an Antibody Loop Increase Breadth of Binding for Influenza Variants. Structure. 2020;S0969-2126(20)30124-6.  Abstract  
submitted by kickingbird at Jul, 2, 2020 from Structure. 2020;S0969-2126(20)30124-6 (via https://pubmed.ncbi.nlm.nih.gov/32610044/)
The influenza hemagglutinin (HA) glycoprotein is the target of many broadly neutralizing antibodies. However, influenza viruses can rapidly escape antibody recognition by mutation of hypervariable regions ...

Jansen AJG, Spaan T, Low HZ, et al. Influenza-induced Thrombocytopenia Is Dependent on the Subtype and Sialoglycan Receptor and Increases With Virus Pathogenicity. Blood Adv. 2020;4(13):2967-2978.  Abstract  
submitted by kickingbird at Jul, 2, 2020 from Blood Adv. 2020;4(13):2967-2978 (via https://pubmed.ncbi.nlm.nih.gov/32609845/)
Thrombocytopenia is a common complication of influenza virus infection, and its severity predicts the clinical outcome of critically ill patients. The underlying cause(s) remain incompletely understood. ...

HL Sun, et al. Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection. PNAS first published June 29, 2020.  Abstract  
submitted by kickingbird at Jun, 30, 2020 from PNAS first published June 29, 2020 (via https://www.pnas.org/content/early/2020/06/23/1921186117)
Pigs are considered as important hosts or “mixing vessels” for the generation of pandemic influenza viruses. Systematic surveillance of influenza viruses in pigs is essential for early warning and preparedness ...

Schofield C, Colombo RE, Richard SA, et al. Comparable Disease Severity by Influenza Virus Subtype in the Acute Respiratory Infection Consortium Natural History Study. Mil Med. 2020;usaa120..  Abstract  
submitted by kickingbird at Jun, 30, 2020 from Mil Med. 2020;usaa120. (via https://pubmed.ncbi.nlm.nih.gov/32588899/)
Introduction: Since the influenza A/H1N1 pandemic of 2009 to 2010, numerous studies have described the clinical course and outcome of the different subtypes of influenza (A/H1N1, A/H3N2, and B). A recent ...

Nüssing S, Mifsud E, Hensen L, et al. Viral Burden, Inflammatory Milieu and CD8 + T-cell Responses to Influenza Virus in a Second-Generation Thiazolide (RM-5061) and Oseltamivir Combination Therapy Study. Influenza Other Respir Viruses. 2020;10.1111/irv.1.  Abstract  
submitted by kickingbird at Jun, 30, 2020 from Influenza Other Respir Viruses. 2020;10.1111/irv.1 (via https://pubmed.ncbi.nlm.nih.gov/32588557/)
Background: Influenza viruses cause significant morbidity and mortality, especially in young children, elderly, pregnant women and individuals with co-morbidities. Patients with severe influenza disease ...

Zhu Y, Wang R, Yu L, et al. Human TRA2A Determines Influenza A Virus Host Adaptation by Regulating Viral mRNA Splicing. Sci Adv. 2020;6(25):eaaz5764.  Abstract  
submitted by kickingbird at Jun, 30, 2020 from Sci Adv. 2020;6(25):eaaz5764 (via https://pubmed.ncbi.nlm.nih.gov/32596447/)
Several avian influenza A viruses (IAVs) have adapted to mammalian species, including humans. To date, the mechanisms enabling these host shifts remain incompletely understood. Here, we show that a host ...

Zu S, Xue Q, He Z, et al. Duck PIAS2 Promotes H5N1 Avian Influenza Virus Replication Through Its SUMO E3 Ligase Activity. Front Microbiol. 2020;11:1246.  Abstract  
submitted by kickingbird at Jun, 30, 2020 from Front Microbiol. 2020;11:1246 (via https://pubmed.ncbi.nlm.nih.gov/32595623/)
The protein inhibitor of the activated STAT2 (PIAS2) has been implicated in many cellular processes and can also regulate viral replication in mammals. However, the role of PIAS2 in the highly pathogenic ...

McCuen MM, Pitesky ME, Buler JJ, et al. A Comparison of Amplification Methods to Detect Avian Influenza Viruses in California Wetlands Targeted via Remote Sensing of Waterfowl. Transbound Emerg Dis. 2020;10.1111/tbed.13612.  Abstract  
submitted by kickingbird at Jun, 30, 2020 from Transbound Emerg Dis. 2020;10.1111/tbed.13612 (via https://pubmed.ncbi.nlm.nih.gov/32592444/)
Migratory waterfowl, including geese and ducks, are indicated as the primary reservoir of avian influenza viruses (AIv) which can be subsequently spread to commercial poultry. The US Department of Agriculture's ...

Zhang Y, Zhang HX, Zheng Q. In Silico Study of Membrane Lipid Composition Regulating Conformation and Hydration of Influenza Virus B M2 Channel. J Chem Inf Model. 2020;10.1021/acs.jcim.0c00329.  Abstract  
submitted by kickingbird at Jun, 27, 2020 from J Chem Inf Model. 2020;10.1021/acs.jcim.0c00329 (via https://pubmed.ncbi.nlm.nih.gov/32589410/)
The proton conduction of transmembrane influenza virus B M2 (BM2) proton channel is possibly mediated by the membrane environment, but the detailed molecular mechanism is challenging to determine. In this ...

Zhou X, Gao L, Wang Y, et al. Geographical Variation in the Risk of H7N9 Human Infections in China: Implications for Risk-Based Surveillance. Sci Rep. 2020;10(1):10372..  Abstract  
submitted by kickingbird at Jun, 27, 2020 from Sci Rep. 2020;10(1):10372. (via https://pubmed.ncbi.nlm.nih.gov/32587266/)
The influenza A (H7N9) subtype remains a public health problem in China affecting individuals in contact with live poultry, particularly at live bird markets. Despite enhanced surveillance and biosecurity ...

Endo M, Tanishima M, Ibaragi K, et al. Clinical Phase II and III Studies of an AS03-adjuvanted H5N1 Influenza Vaccine Produced in an EB66 ? Cell Culture Platform. Influenza Other Respir Viruses. 2020;10.1111/irv..  Abstract  
submitted by kickingbird at Jun, 26, 2020 from Influenza Other Respir Viruses. 2020;10.1111/irv. (via https://pubmed.ncbi.nlm.nih.gov/32579785/)
Background: We have developed an AS03-adjuvanted H5N1 influenza vaccine produced in an EB66? cell culture platform (KD-295). Objectives: In accordance with Japanese guidelines for development of pandemic ...

Hao W, Wang L, Li S. FKBP5 Regulates RIG-I-Mediated NF-κB Activation and Influenza A Virus Infection. Viruses. 2020;12(6):E672.  Abstract  
submitted by kickingbird at Jun, 26, 2020 from Viruses. 2020;12(6):E672 (via https://pubmed.ncbi.nlm.nih.gov/32580383/)
Influenza A virus (IAV) is a highly transmissible respiratory pathogen and is a constant threat to global health with considerable economic and social impact. Influenza viral RNA is sensed by host pattern ...

Everest H, Hill SC, Daines R, et al. The Evolution, Spread and Global Threat of H6Nx Avian Influenza Viruses. Viruses. 2020;12(6):E673.  Abstract  
submitted by kickingbird at Jun, 26, 2020 from Viruses. 2020;12(6):E673 (via https://pubmed.ncbi.nlm.nih.gov/32580412/)
Avian influenza viruses of the subtype H6Nx are being detected globally with increasing frequency. Some H6Nx lineages are becoming enzootic in Asian poultry and sporadic incursions into European poultry ...

Giotis ES. Inferring the Urban Transmission Potential of Bat Influenza Viruses. Front Cell Infect Microbiol. 2020;10:264.  Abstract  
submitted by kickingbird at Jun, 26, 2020 from Front Cell Infect Microbiol. 2020;10:264 (via https://pubmed.ncbi.nlm.nih.gov/32582567/)
Bats are considered natural reservoirs of various, potentially zoonotic viruses, exemplified by the influenza A-like viruses H17N10 and H18N11 in asymptomatic Neotropical bats. These influenza viruses ...

Xia J, Adam DC, Moa A, et al. Comparative Epidemiology, Phylogenetics, and Transmission Patterns of Severe Influenza A/H3N2 in Australia From 2003 to 2017. Influenza Other Respir Viruses. 2020;10.1111/irv..  Abstract  
submitted by kickingbird at Jun, 25, 2020 from Influenza Other Respir Viruses. 2020;10.1111/irv. (via https://pubmed.ncbi.nlm.nih.gov/32558378/)
Background: Over the last two decades, Australia has experienced four severe influenza seasons caused by a predominance of influenza A (A/H3N2): 2003, 2007, 2012, and 2017. Methods: We compared the epidemiology, ...

Islam SS, Akwar H, Hossain MM, et al. Qualitative Risk Assessment of Transmission Pathways of Highly Pathogenic Avian Influenza (HPAI) Virus at Live Poultry Markets in Dhaka City, Bangladesh. Zoonoses Public Health. 2020;10.1111/zph.12746.  Abstract  
submitted by kickingbird at Jun, 25, 2020 from Zoonoses Public Health. 2020;10.1111/zph.12746 (via https://pubmed.ncbi.nlm.nih.gov/32558220/)
Analysis of environmental samples obtained from the Live Poultry Markets (LPMs) of Dhaka City, Bangladesh, has revealed that the highest degree of prevalence of highly pathogenic avian influenza A (HPAI, ...

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