Li M, Feng S, Lv S, Luo J, Guo J, Sun J, He H. Highly pathogenic H5N6 avian influenza virus outbreak in Pavo cristatus in Jiangxi Province, China. Emerg Microbes Infect. 2019;8(1):377-380.. Abstract
submitted by kickingbird at Dec, 21, 2019 from Emerg Microbes Infect. 2019;8(1):377-380. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Highly pathogenic avian influenza (HPAI) is a persistent threat to poultry, wild birds, humans, and other mammals. The continually evolving HPAI H5N6 virus has induced great losses in breeding industries ...
Mohamed W, Ito K, Omori R. Estimating Transmission Potential of H5N1 Viruses Among Humans in Egypt Using Phylogeny, Genetic Distance and Sampling Time Interval. Front Microbiol. 2019 Dec 3;10:2765. Abstract
submitted by kickingbird at Dec, 21, 2019 from Front Microbiol. 2019 Dec 3;10:2765 (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0276)
In 2014 and 2015, the number of human cases of H5N1 avian influenza virus infections had increased dramatically in Egypt. This increase might be related to increase in the transmission potential of the ...
Li G, et al. Insulin-Like Growth Factor 1 Regulates Acute Inflammatory Lung Injury Mediated by Influenza Virus Infection. Front Microbiol. 2019 Nov 26;10:2541.. Abstract
submitted by kickingbird at Dec, 21, 2019 from Front Microbiol. 2019 Nov 26;10:2541. (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0254)
The acute inflammatory lung injury is an important cause of death due to influenza A virus (IAV) infection. Insulin-like growth factor 1 (IGF1) played an important role in the regulation of inflammation ...
Li YT, et al. Avian influenza viruses in humans: lessons from past outbreaks. Br Med Bull. 2019 Dec 14. Abstract
submitted by kickingbird at Dec, 21, 2019 from Br Med Bull. 2019 Dec 14 (via https://academic.oup.com/bmb/advance-article-abstract/doi/10)
BACKGROUND: Human infections with avian influenza viruses (AIV) represent a persistent public health threat. The principal risk factor governing human infection with AIV is from direct contact with infected ...
Kuwahara T, Yamayoshi S, Noda T, Kawaoka Y. G Protein Pathway Suppressor 1 Promotes Influenza Virus Polymerase Activity by Activating the NF-κB Signaling Pathway. MBio. 2019 Dec 17;10(6). pii: e02867-19.. Abstract
submitted by kickingbird at Dec, 21, 2019 from MBio. 2019 Dec 17;10(6). pii: e02867-19. (via https://mbio.asm.org/content/10/6/e02867-19)
Influenza virus relies heavily on cellular machinery to replicate in host cells. Therefore, to better understand the influenza virus life cycle, it is important to identify which host proteins are involved ...
Konstantinidi A, et al. The boundary lipid around DMPC-spanning influenza A M2 transmembrane domain channels: Its structure and potential for drug accommodation. Biochim Biophys Acta Biomembr. 2019 Dec 14:183156.. Abstract
submitted by kickingbird at Dec, 21, 2019 from Biochim Biophys Acta Biomembr. 2019 Dec 14:183156. (via https://www.sciencedirect.com/science/article/pii/S000527361)
We have investigated the perturbation of influenza A M2TM in DMPC bilayers. We have shown that (a) DSC and SAXS detect changes in membrane organization caused by small changes (micromolar) in M2TM or aminoadamantane ...
Jureka AS, et al. The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I. J Biol Chem. 2019 Dec 16.. Abstract
submitted by kickingbird at Dec, 21, 2019 from J Biol Chem. 2019 Dec 16. (via http://www.jbc.org/content/early/2019/12/16/jbc.RA119.011410)
A critical role of the influenza A virus non-structural protein 1 (NS1) is to antagonize the host cellular antiviral response. NS1 accomplishes this role through numerous interactions with host proteins ...
McCarthy KR, et al. Affinity maturation in a human humoral response to influenza hemagglutinin. PNAS 2019 Dec 16. Abstract
submitted by kickingbird at Dec, 21, 2019 from PNAS 2019 Dec 16 (via https://www.ncbi.nlm.nih.gov/pubmed/31843892)
Affinity maturation of the B cell antigen receptor (BCR) is a conserved and crucial component of the adaptive immune response. BCR lineages, inferred from paired heavy- and light-chain sequences of rearranged ...
Nickbakhsh S, et al. Virus-virus interactions impact the population dynamics of influenza and the common cold. PNAS 2019 Dec 16. Abstract
submitted by kickingbird at Dec, 21, 2019 from PNAS 2019 Dec 16 (via https://www.pnas.org/content/early/2019/12/10/1911083116)
The human respiratory tract hosts a diverse community of cocirculating viruses that are responsible for acute respiratory infections. This shared niche provides the opportunity for virus-virus interactions ...
Virk RK, et al. Divergent evolutionary trajectories of influenza B viruses underlie their contemporaneous epidemic activity. PNAS 2019 Dec 16. Abstract
submitted by kickingbird at Dec, 21, 2019 from PNAS 2019 Dec 16 (via https://www.pnas.org/content/early/2019/12/13/1916585116)
Influenza B viruses have circulated in humans for over 80 y, causing a significant disease burden. Two antigenically distinct lineages ("B/Victoria/2/87-like" and "B/Yamagata/16/88-like," termed Victoria ...
de Vries RD, et al. Analysis Of The Vaccine-Induced Influenza B Virus Hemagglutinin-Specific Antibody Dependent Cellular Cytotoxicity Response. Virus Res. 2019 Dec 11:197839.. Abstract
submitted by kickingbird at Dec, 16, 2019 from Virus Res. 2019 Dec 11:197839. (via https://www.ncbi.nlm.nih.gov/pubmed/31837382)
Influenza A virus (IAV) and influenza B virus (IBV) cause substantial morbidity and mortality during seasonal epidemics. On basis of variation in the surface glycoprotein hemagglutinin, two antigenically ...
Kiso M, Yamayoshi S, Murakami J, Kawaoka Y. Baloxavir marboxil treatment of nude mice infected with influenza A virus. J Infect Dis. 2019 Dec 14. Abstract
submitted by kickingbird at Dec, 16, 2019 from J Infect Dis. 2019 Dec 14 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
Immunocompromised patients infected with influenza virus require prolonged treatment with neuraminidase inhibitors, because these patients are not able to eradicate the virus from the respiratory tract, ...
Krammer F, et al. Meeting report and review: Immunological assays and correlates of protection for next-generation influenza vaccines. Influenza Other Respir Viruses. 2019 Dec 13.. Abstract
submitted by kickingbird at Dec, 16, 2019 from Influenza Other Respir Viruses. 2019 Dec 13. (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12706)
BACKGROUND: This report summarizes the discussions and conclusions from the "Immunological Assays and Correlates of Protection for Next-Generation Influenza Vaccines" meeting which took place in Siena, ...
Luckey D, et al. Immunity to Influenza is dependent on MHC II polymorphism: study with 2 HLA transgenic strains. Sci Rep. 2019 Dec 13;9(1):19061. Abstract
submitted by kickingbird at Dec, 16, 2019 from Sci Rep. 2019 Dec 13;9(1):19061 (via https://www.nature.com/articles/s41598-019-55503-1)
Major histocompatibility complex II (MHC II) molecules are involved in antigen presentation and the development of a functional adaptive immune response. Evolutionary selection for MHC molecules that effectively ...
Matos ADR, et al. Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities. Emerg Microbes Infect. 2019;8(1):1763-1776. Abstract
submitted by kickingbird at Dec, 15, 2019 from Emerg Microbes Infect. 2019;8(1):1763-1776 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Influenza is an acute respiratory infection causing high morbidity and mortality in annual outbreaks worldwide. Antiviral drugs are limited and pose the risk of resistance development, calling for new ...
Traxler S, et al. Volatile scents of influenza A and S. pyogenes (co-)infected cells. Sci Rep. 2019 Dec 11;9(1):18894. Abstract
submitted by kickingbird at Dec, 15, 2019 from Sci Rep. 2019 Dec 11;9(1):18894 (via https://www.nature.com/articles/s41598-019-55334-0)
Influenza A is a serious pathogen itself, but often leads to dangerous co-infections in combination with bacterial species such as Streptococcus pyogenes. In comparison to classical biochemical methods, ...
Qiu Y, et al. Mapping of a Novel H3-Specific Broadly Neutralizing Monoclonal Antibody Targeting the Hemagglutinin Globular Head Isolated from an Elite Influenza Virus-Immunized Donor Exhibiting Serological Breadth. J Virol. 2019 Dec 11. Abstract
submitted by kickingbird at Dec, 15, 2019 from J Virol. 2019 Dec 11 (via https://jvi.asm.org/content/early/2019/12/05/JVI.01035-19)
The discovery of potent and broadly protective influenza epitopes could lead to improved vaccines that are resistant to antigenic drift. Here, we describe human antibody C585, isolated from a vaccinee ...
Parsons L, et al. Influenza Hemagglutinins H2, H5, H6, and H11 are not Targets of Pulmonary Surfactant Protein D: N-glycan subtypes in host-pathogen interactions. J Virol. 2019 Dec 11. pii: JVI.01951-19.. Abstract
submitted by kickingbird at Dec, 15, 2019 from J Virol. 2019 Dec 11. pii: JVI.01951-19. (via https://jvi.asm.org/content/early/2019/12/05/JVI.01951-19)
Seasonal influenza carrying key hemagglutinin (HA) head region glycosylation sites can be removed from the lung by pulmonary surfactant protein D (SP-D). Little is known about HA head glycosylation of ...
Hallmann-Szelińska E, et al. Virological and Epidemiological Situation in the Influenza Epidemic Seasons 2016/2017 and 2017/2018 in Poland. Adv Exp Med Biol. 2019 Dec 13.. Abstract
submitted by kickingbird at Dec, 15, 2019 from Adv Exp Med Biol. 2019 Dec 13. (via https://link.springer.com/chapter/10.1007%2F5584_2019_454)
The World Health Organization estimates that influenza virus infects 3-5 million people worldwide every year, of whom 290,000 to 650,000 die. In the 2016/2017 epidemic season in Poland, the incidence of ...
Abolnik C. Outbreaks of Clade 220.127.116.11 H5N8 highly pathogenic avian influenza in 2018 in the northern regions of South Africa were unrelated to those of 2017. Transbound Emerg Dis. 2019 Dec 13.. Abstract
submitted by kickingbird at Dec, 15, 2019 from Transbound Emerg Dis. 2019 Dec 13. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13448)
Asian-origin H5N8 highly pathogenic avian influenza (HPAI) viruses of the H5 Goose/Guangdong/96 lineage, clade 18.104.22.168 group B reached South Africa by June 2017. By the end of that year, 5.4 million layers ...
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