Correia R, Fernandes B, Alves PM, Carrondo MJT, Ro. Improving Influenza HA-Vlps Production in Insect High Five Cells via Adaptive Laboratory Evolution. Vaccines (Basel). 2020 Oct 7;8(4):E589. Abstract
submitted by kickingbird at Oct, 12, 2020 from Vaccines (Basel). 2020 Oct 7;8(4):E589 (via https://www.mdpi.com/2076-393X/8/4/589)
The use of non-standard culture conditions has proven efficient to increase cell performance and recombinant protein production in different cell hosts. However, the establishment of high-producing cell ...
Guilfoyle K, Major D, Skeldon S, James H, Tingsted. Protective efficacy of a polyvalent influenza A DNA vaccine against both homologous (H1N1pdm09) and heterologous (H5N1) challenge in the ferret model. Vaccine. 2020 Oct 6:S0264-410X(20)31233-0. Abstract
submitted by kickingbird at Oct, 12, 2020 from Vaccine. 2020 Oct 6:S0264-410X(20)31233-0 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
This study describes the protective efficacy of a novel influenza plasmid DNA vaccine in the ferret challenge model. The rationally designed polyvalent influenza DNA vaccine encodes haemagglutinin and ...
Brehony C, Dunford L, Bennett C, O´Donnell J. Neuraminidase characterisation reveals very low levels of antiviral resistance and the presence of mutations associated with reduced antibody effectiveness in the Irish influenza 2018/2019 season. J Clin Virol. 2020 Oct 1;132:104653. Abstract
submitted by kickingbird at Oct, 12, 2020 from J Clin Virol. 2020 Oct 1;132:104653 (via https://www.sciencedirect.com/science/article/pii/S138665322)
Neuraminidase inhibitor (NAI) resistance levels globally are currently low. However, as antivirals are increasingly being used, and even in the absence of selective pressure, resistance may increase or ...
Arai Y, Kawashita N, Elgendy EM, Ibrahim MS, Daido. PA mutations inherited during viral evolution act cooperatively to increase replication of contemporary H5N1 influenza virus with an expanded host range. J Virol. 2020 Oct 7:JVI.01582-20. Abstract
submitted by kickingbird at Oct, 11, 2020 from J Virol. 2020 Oct 7:JVI.01582-20 (via https://jvi.asm.org/content/early/2020/10/02/JVI.01582-20)
Adaptive mutations and/or reassortments in avian influenza virus polymerase subunits PA, PB1 and PB2 are one of the major factors enabling the virus to overcome the species barrier to infect humans. The ...
Wei Y, Zeng Y, Zhang X, Xu S, Wang Z, Du Y, Zhang. The Nucleoprotein of H7N9 Influenza Virus Positively Regulates TRAF3-Mediated Innate Signaling and Attenuates Viral Virulence in Mice. J Virol. 2020 Oct 7:JVI.01640-20. Abstract
submitted by kickingbird at Oct, 11, 2020 from J Virol. 2020 Oct 7:JVI.01640-20 (via https://jvi.asm.org/content/early/2020/10/02/JVI.01640-20)
H7N9 influenza A virus (IAV) is an emerged contagious pathogen that may cause severe human infections, even death. Understanding the precise cross-talk between virus and host is vital for the development ...
Honce R, Schultz-Cherry S. Recipe for Zoonosis: How Influenza Virus Leaps into Human Circulation. Cell Host Microbe. 2020 Oct 7;28(4):506-508. Abstract
submitted by kickingbird at Oct, 11, 2020 from Cell Host Microbe. 2020 Oct 7;28(4):506-508 (via https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(2)
The features that permit or prevent a virus from becoming a zoonotic threat is an ongoing area of investigation. In this issue of Cell Host & Microbe, Herfst et al. and Henritzi et al. help define the ...
Youk S, Lee DH, Killian ML, Pantin-Jackwood MJ, Sw. Highly Pathogenic Avian Influenza A(H7N3) Virus in Poultry, United States, 2020. Emerg Infect Dis. 2020 Oct 8;26(12). Abstract
submitted by kickingbird at Oct, 11, 2020 from Emerg Infect Dis. 2020 Oct 8;26(12) (via https://wwwnc.cdc.gov/eid/article/26/12/20-2790_article)
An outbreak of low-pathogenicity avian influenza A(H7N3) virus of North American wild bird lineage occurred on commercial turkey farms in North Carolina and South Carolina, USA, during March-April 2020. ...
Li Y, Li M, Li Y, Tian J, Bai X, Yang C, Shi J, Ai. Outbreaks of Highly Pathogenic Avian Influenza (H5N6) Virus Subclade 184.108.40.206h in Swans, Xinjiang, Western China, 2020. Emerg Infect Dis. 2020 Oct 8;26(12). Abstract
submitted by kickingbird at Oct, 11, 2020 from Emerg Infect Dis. 2020 Oct 8;26(12) (via https://wwwnc.cdc.gov/eid/article/26/12/20-1201_article)
In January 2020, the subclade 220.127.116.11h of highly pathogenic avian influenza (H5N6) virus infected migratory whooper swans and mute swans in Xinjiang, western China. The virus is lethal to chickens and ...
Laleye AT, Abolnik C. Emergence of highly pathogenic H5N2 and H7N1 influenza A viruses from low pathogenic precursors by serial passage in ovo. PLoS One. 2020 Oct 8;15(10):e0240290. Abstract
submitted by kickingbird at Oct, 11, 2020 from PLoS One. 2020 Oct 8;15(10):e0240290 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Highly pathogenic (HPAI) strains emerge from their low pathogenic (LPAI) precursors and cause severe disease in poultry with enormous economic losses, and zoonotic potential. Understanding the mechanisms ...
Herfst S, Zhang J, Richard M, McBride R, Lexmond P. Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals. Cell Host Microbe. 2020 Oct 7;28(4):602-613.e7. Abstract
submitted by kickingbird at Oct, 11, 2020 from Cell Host Microbe. 2020 Oct 7;28(4):602-613.e7 (via https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(2)
In 2014, an outbreak of avian A/H10N7 influenza virus occurred among seals along North-European coastal waters, significantly impacting seal populations. Here, we examine the cross-species transmission ...
Chu HY, Boeckh M, Englund JA, Famulare M, Lutz B,. The Seattle Flu Study: a multiarm community-based prospective study protocol for assessing influenza prevalence, transmission and genomic epidemiology. BMJ Open. 2020 Oct 7;10(10):e037295. Abstract
submitted by kickingbird at Oct, 11, 2020 from BMJ Open. 2020 Oct 7;10(10):e037295 (via https://bmjopen.bmj.com/content/10/10/e037295)
Introduction: Influenza epidemics and pandemics cause significant morbidity and mortality. An effective response to a potential pandemic requires the infrastructure to rapidly detect, characterise, and ...
Gulyaeva M, Huettmann F, Shestopalov A, Okamatsu M. Data mining and model-predicting a global disease reservoir for low-pathogenic Avian Influenza (A) in the wider pacific rim using big data sets. Sci Rep. 2020 Oct 8;10(1):16817. Abstract
submitted by kickingbird at Oct, 11, 2020 from Sci Rep. 2020 Oct 8;10(1):16817 (via https://www.nature.com/articles/s41598-020-73664-2)
Avian Influenza (AI) is a complex but still poorly understood disease; specifically when it comes to reservoirs, co-infections, connectedness and wider landscape perspectives. Low pathogenic (Low-path ...
Bedford JG, Caminschi I, Wakim LM. Intranasal Delivery of a Chitosan-Hydrogel Vaccine Generates Nasal Tissue Resident Memory CD8 + T Cells That Are Protective against Influenza Virus Infection. Vaccines (Basel). 2020 Oct 1;8(4):E572. Abstract
submitted by kickingbird at Oct, 8, 2020 from Vaccines (Basel). 2020 Oct 1;8(4):E572 (via https://www.mdpi.com/2076-393X/8/4/572)
Rapid antigen clearance from the nasal mucosa is one of the major challenges in the development of intranasal vaccines. Here, we tested whether intranasal immunization with a chitosan-hydrogel vaccine, ...
Tannig P, Peter AS, Lapuente D, Klessing S, Schmid. Genetic Co-Administration of Soluble PD-1 Ectodomains Modifies Immune Responses against Influenza A Virus Induced by DNA Vaccination. Vaccines (Basel). 2020 Oct 1;8(4):E570. Abstract
submitted by kickingbird at Oct, 8, 2020 from Vaccines (Basel). 2020 Oct 1;8(4):E570 (via https://www.mdpi.com/2076-393X/8/4/570)
Due to the low efficacy and the need for seasonal adaptation of currently licensed influenza A vaccines, the importance of alternative vaccination strategies is increasingly recognized. Considering that ...
Zhang C, Wang Y, Chen C, Long H, Bai J, Zeng J, Ca. A Mutation Network Method for Transmission Analysis of Human Influenza H3N2. Viruses. 2020 Oct 3;12(10):E1125. Abstract
submitted by kickingbird at Oct, 8, 2020 from Viruses. 2020 Oct 3;12(10):E1125 (via https://www.mdpi.com/1999-4915/12/10/1125)
Characterizing the spatial transmission pattern is critical for better surveillance and control of human influenza. Here, we propose a mutation network framework that utilizes network theory to study the ...
Hooshmand E, Moa A, Trent M, Kunasekaran M, Poulos. Epidemiology of 2017 influenza outbreaks in nine Australian Aged care facilities. Influenza Other Respir Viruses. 2020 Oct 7. doi: 1. Abstract
submitted by kickingbird at Oct, 8, 2020 from Influenza Other Respir Viruses. 2020 Oct 7. doi: 1 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.12811)
Background: The 2017 A/H3N2 influenza season was the most severe season since the 2009 influenza pandemic. There were over 591 influenza outbreaks in institutions across the state of New South Wales (NSW) ...
Takahashi H, Fujimoto T, Horikoshi F, Uotani T, Ok. Determination of the potency of a cell-based seasonal quadrivalent influenza vaccine using a purified primary liquid standard. Biologicals. 2020 Oct 3:S1045-1056(20)30111-1. Abstract
submitted by kickingbird at Oct, 8, 2020 from Biologicals. 2020 Oct 3:S1045-1056(20)30111-1 (via https://www.sciencedirect.com/science/article/pii/S104510562)
In Japan, the practical application of completely cell-based seasonal influenza vaccines is under consideration. Considering the good correlation between the immunogenicity of egg-based influenza vaccines ...
Jiang H, Peng W, Qi J, Chai Y, Song H, Bi Y, Rijal. Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus. mBio. 2020 Oct 6;11(5):e02315-20. Abstract
submitted by kickingbird at Oct, 8, 2020 from mBio. 2020 Oct 6;11(5):e02315-20 (via https://mbio.asm.org/content/11/5/e02315-20)
Here, we investigate a monoclonal antibody, Z2B3, isolated from an H7N9-infected patient, that exhibited cross-reactivity to both N9 (group 2) and a broad range of seasonal and avian N1 (group 1) proteins ...
Hu J, Zhang L, Liu X. Role of Post-translational Modifications in Influenza A Virus Life Cycle and Host Innate Immune Response. Front Microbiol. 2020 Sep 4;11:517461. Abstract
submitted by kickingbird at Oct, 6, 2020 from Front Microbiol. 2020 Sep 4;11:517461 (via https://www.frontiersin.org/articles/10.3389/fmicb.2020.5174)
Throughout various stages of its life cycle, influenza A virus relies heavily on host cellular machinery, including the post-translational modifications (PTMs) system. During infection, influenza virus ...
Li Y, Chai W, Min J, Ye Z, Tong X, Qi D, Liu W, Lu. Neddylation of M1 negatively regulates the replication of influenza A virus. J Gen Virol. 2020 Oct 5. Abstract
submitted by kickingbird at Oct, 6, 2020 from J Gen Virol. 2020 Oct 5 (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Post-translational modification plays a critical role in viral replication. Previously we reported that neddylation of PB2 of influenza A virus (IAV) can inhibit viral replication. However, we found that ...
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