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2019-7-23 3:43:07
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Hagag NM, et al. Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt. Viruses. 2019 Jun 18;11(6)..  Abstract  
submitted by kickingbird at Jun, 21, 2019 from Viruses. 2019 Jun 18;11(6). (via https://www.mdpi.com/1999-4915/11/6/565)
Highly pathogenic avian influenza (HPAI) H5N1 and H5N8 have become endemic among domestic poultry in Egypt since 2006 and 2016, respectively. In parallel, the low pathogenic avian influenza H9N2 virus ...

Litvinova M, Liu QH, Kulikov ES, Ajelli M. Reactive school closure weakens the network of social interactions and reduces the spread of influenza. PNAS 2019 Jun 17.  Abstract  
submitted by kickingbird at Jun, 19, 2019 from PNAS 2019 Jun 17 (via https://www.pnas.org/content/early/2019/06/11/1821298116)
School-closure policies are considered one of the most promising nonpharmaceutical interventions for mitigating seasonal and pandemic influenza. However, their effectiveness is still debated, primarily ...

Peng Q, et al. Structural insight into RNA synthesis by influenza D polymerase. Nat Microbiol. 2019 Jun 17.  Abstract  
submitted by kickingbird at Jun, 19, 2019 from Nat Microbiol. 2019 Jun 17 (via https://www.nature.com/articles/s41564-019-0487-5)
The influenza virus polymerase uses capped RNA primers to initiate transcription, and a combination of terminal and internal de novo initiations for the two-step replication process by binding the conserved ...

Libin Liang, et al. Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals. mBio.  Abstract  
submitted by kickingbird at Jun, 19, 2019 from mBio (via https://mbio.asm.org/content/10/3/e01162-19)
Avian influenza viruses (AIVs) must acquire mammalian-adaptive mutations before they can efficiently replicate in and transmit among humans. The PB2 E627K mutation is known to play a prominent role in ...

Gao L, et al. Integration analysis of a miRNA-mRNA expression in A549 cells infected with a novel H3N2 swine influenza virus and the 2009 H1N1 pandemic influenza virus. Infect Genet Evol. 2019 Jun 14:103922.  Abstract  
submitted by kickingbird at Jun, 18, 2019 from Infect Genet Evol. 2019 Jun 14:103922 (via https://www.ncbi.nlm.nih.gov/pubmed/31207403)
Swine are reservoirs for anthropogenic/zoonotic influenza viruses, and the prevalence and repeated introduction of the 2009 H1N1 pandemic influenza virus (pdm/09) into pigs raises the possibility of generating ...

Suttie A, et al. Avian influenza in the Greater Mekong Subregion, 2003~2018. Infect Genet Evol. 2019 Jun 12:103920..  Abstract  
submitted by kickingbird at Jun, 18, 2019 from Infect Genet Evol. 2019 Jun 12:103920. (via https://www.sciencedirect.com/science/article/pii/S156713481)
The persistent circulation of avian influenza viruses (AIVs) is an ongoing problem for many countries in South East Asia, causing large economic losses to both the agricultural and health sectors. This ...

Roe M, et al. Report on influenza viruses received and tested by the Melbourne WHO Collaborating Centre for Reference and Research on Influenza in 2017. Commun Dis Intell (2018). 2019 Jun 17;43.  Abstract  
submitted by kickingbird at Jun, 18, 2019 from Commun Dis Intell (2018). 2019 Jun 17;43 (via https://www.ncbi.nlm.nih.gov/pubmed/31203585)
As part of its role in the World Health Organization’s (WHO) Global Influenza Surveillance and Response System (GISRS), the WHO Collaborating Centre for Reference and Research on Influenza in Melbourne ...

Su W, et al. Seroprevalence of dogs in Hong Kong to human and canine influenza viruses. Vet Rec Open. 2019 Apr 11;6(1):e000327.  Abstract  
submitted by kickingbird at Jun, 18, 2019 from Vet Rec Open. 2019 Apr 11;6(1):e000327 (via https://vetrecordopen.bmj.com/content/6/1/e000327)
As a unique mammalian host for influenza A viruses, dogs support the transmission of canine influenza viruses (CIVs) of H3N8 and H3N2 subtypes and are susceptible to infection by avian and human influenza ...

Andreychuk DB, et al. Armored Exogenous Internal Control for Real-Time PCR Diagnosis of Avian Influenza. Avian Pathol. 2019 Jun 17:1-15..  Abstract  
submitted by kickingbird at Jun, 18, 2019 from Avian Pathol. 2019 Jun 17:1-15. (via https://www.tandfonline.com/doi/abs/10.1080/03079457.2019.16)
An exogenous "armored" PCR internal control (IC) short RNA was analyzed in conjunction with real-time RT-PCR method for diagnosis of avian influenza. The resistance to nucleases and increase the physical ...

Oliva J, et al. Serological Evidence of Influenza D Virus Circulation Among Cattle and Small Ruminants in France. Viruses. 2019 Jun 5;11(6).  Abstract  
submitted by kickingbird at Jun, 16, 2019 from Viruses. 2019 Jun 5;11(6) (via https://www.mdpi.com/1999-4915/11/6/516)
Influenza D virus (IDV) has first been identified in 2011 in the USA and was shown to mainly circulate in cattle. While IDV is associated with mild respiratory signs, its prevalence is still unknown. In ...

Cheng W, et al. Comparison of Avian Influenza Virus Contamination in the Environment Before and After Massive Poultry H5/H7 Vaccination in Zhejiang Province, China. Open Forum Infect Dis. 2019 Apr 24;6(6):ofz197.  Abstract  
submitted by kickingbird at Jun, 16, 2019 from Open Forum Infect Dis. 2019 Apr 24;6(6):ofz197 (via https://academic.oup.com/ofid/article/6/6/ofz197/5478571)
Background: Information regarding comparison of the environmental prevalence of avian influenza virus (AIVs), before and after massive poultry vaccinations, is limited. Our study aimed to detect differences ...

Wu H, Yang F, Xiao Y, Liu F, Yao H, Wu N. Adaptive amino acid substitutions enhance the virulence of an avian-origin H6N1 influenza virus in mice. Infect Genet Evol. 2019 Jun 11:103918.  Abstract  
submitted by kickingbird at Jun, 16, 2019 from Infect Genet Evol. 2019 Jun 11:103918 (via https://www.sciencedirect.com/science/article/pii/S156713481)
The H6N1 subtype avian influenza virus (AIV) is a zoonotic infectious disease pathogen, which poses a threat to human health. In order to study the possible substitution of H6N1 AIV for mammals, an avian-origin ...

Yang L, et al. Emergence of waterfowl-originated gene cassettes in HPAI H7N9 viruses caused severe human infection in Fujian, China. Influenza Other Respir Viruses. 2019 Jun 11.  Abstract  
submitted by kickingbird at Jun, 14, 2019 from Influenza Other Respir Viruses. 2019 Jun 11 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12657)
BACKGROUND: Highly pathogenic avian influenza (HPAI) A(H7N9) virus emerged and caused human infections during the 2016-2017 epidemic wave of influenza A(H7N9) viruses in China. We report a human infection ...

Hodges EN, et al. Detection of oseltamivir-resistant zoonotic and animal influenza A viruses using the rapid influenza antiviral resistance test. Influenza Other Respir Viruses. 2019 Jun 11..  Abstract  
submitted by kickingbird at Jun, 14, 2019 from Influenza Other Respir Viruses. 2019 Jun 11. (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12661)
Mutations in the influenza virus neuraminidase (NA) that cause reduced susceptibility to the NA inhibitor (NAI) oseltamivir may occur naturally or following antiviral treatment. Currently, detection uses ...

Thomaston JL, Wu Y, Polizzi N, Liu L, et al. X-ray crystal structure of the influenza A M2 proton channel S31N mutant in two conformational states: an open and shut case. J Am Chem Soc. 2019 Jun 11..  Abstract  
submitted by kickingbird at Jun, 14, 2019 from J Am Chem Soc. 2019 Jun 11. (via https://pubs.acs.org/doi/10.1021/jacs.9b02196)
The amantadine-resistant S31N mutant of the influenza A M2 proton channel has become prevalent in currently circulating viruses. Here we have solved an X-ray crystal structure of M2(22-46) S31N that contains ...

Loth L, Pham LT, Stevenson MA. Spatio-temporal distribution of outbreaks of highly pathogenic avian influenza virus subtype H5N1 in Vietnam, 2015~2018. Transbound Emerg Dis. 2019 Jun 10..  Abstract  
submitted by kickingbird at Jun, 13, 2019 from Transbound Emerg Dis. 2019 Jun 10. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13259)
Despite strong commitments of the central and provincial veterinary authorities in Vietnam to control highly pathogenic avian influenza H5N1 (HPAI-H5N1) in poultry and to diminish the risk of human infection, ...

Qiang X, Kou Z. Scoring amino acid mutation to predict pandemic risk of avian influenza virus. BMC Bioinformatics. 2019 Jun 10.  Abstract  
submitted by kickingbird at Jun, 13, 2019 from BMC Bioinformatics. 2019 Jun 10 (via https://bmcbioinformatics.biomedcentral.com/articles/10.1186)
BACKGROUND: Avian influenza virus can directly cross species barriers and infect humans with high fatality. As antigen novelty for human host, the public health is being challenged seriously. The pandemic ...

Du W, et al. The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance. PLoS Pathog. 2019 Jun 10;15(6):e1007860.  Abstract  
submitted by kickingbird at Jun, 13, 2019 from PLoS Pathog. 2019 Jun 10;15(6):e1007860 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A virus (IAV) neuraminidase (NA) receptor-destroying activity and hemagglutinin (HA) receptor-binding affinity need to be balanced with the host receptor repertoire for optimal viral fitness. ...

Eladl AH, Alzayat AA, Ali HS, Fahmy HA, Ellakany H. Comparative molecular characterization, pathogenicity and seroprevalence of avian influenza virus H9N2 in commercial and backyard poultry flocks. Comp Immunol Microbiol Infect Dis. 2019 Jun;64:81-.  Abstract  
submitted by kickingbird at Jun, 11, 2019 from Comp Immunol Microbiol Infect Dis. 2019 Jun;64:81- (via https://www.sciencedirect.com/science/article/pii/S014795711)
This study was conducted to perform the comparative molecular characterization of avian influenza virus (AIV) H9N2, pathogenicity and seroprevalence in commercial and backyard poultry flocks. Fifty commercial ...

Musharrafieh R, et al. The L46P mutant confers a novel allosteric mechanism of resistance towards the influenza A virus M2 S31N proton channel blockers. Mol Pharmacol. 2019 Jun 7.  Abstract  
submitted by kickingbird at Jun, 11, 2019 from Mol Pharmacol. 2019 Jun 7 (via http://molpharm.aspetjournals.org/content/early/2019/06/07/m)
The FDA-approved influenza A antiviral amantadine inhibits the wild-type (WT) AM2 channel but not the S31N mutant predominantly found in circulating strains. In this study, serial viral passages were applied ...

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