Hernandez-Mejia G, Hernandez-Vargas EA. Uncovering antibody cross-reaction dynamics in influenza A infections. Bioinformatics. 2020;btaa691. Abstract
submitted by kickingbird at Jul, 31, 2020 from Bioinformatics. 2020;btaa691 (via https://pubmed.ncbi.nlm.nih.gov/32730562/)
Motivation: Influenza viruses are a cause of large outbreaks and pandemics with high death tolls. A key obstacle is that flu vaccines have inconsistent performance, in the best cases up to 60% effectiveness, ...
Pulit-Penaloza JA, Brock N, Pappas C, et al. Characterization of highly pathogenic avian influenza H5Nx viruses in the ferret model. Sci Rep. 2020;10(1):12700. Abstract
submitted by kickingbird at Jul, 31, 2020 from Sci Rep. 2020;10(1):12700 (via https://pubmed.ncbi.nlm.nih.gov/32728042/)
Highly pathogenic avian influenza (HPAI) H5 viruses, of the A/goose/Guangdong/1/1996 lineage, have exhibited substantial geographic spread worldwide since the first detection of H5N1 virus in 1996. Accumulation ...
Li C, Wang T, Zhang Y, Wei F. Evasion mechanisms of the type I interferons responses by influenza A virus. Crit Rev Microbiol. 2020;1-13. Abstract
submitted by kickingbird at Jul, 28, 2020 from Crit Rev Microbiol. 2020;1-13 (via https://www.tandfonline.com/doi/full/10.1080/1040841X.2020.1)
The type I interferons (IFNs) represent the first line of host defense against influenza virus infection, and the precisely control of the type I IFNs responses is a central event of the immune defense ...
Wei J, Li Z, Yang Y, et al. A biomimetic VLP influenza vaccine with interior NP/exterior M2e antigens constructed through a temperature shift-based encapsulation strategy. Vaccine. 2020;S0264-410X(20)30915-4. Abstract
submitted by kickingbird at Jul, 28, 2020 from Vaccine. 2020;S0264-410X(20)30915-4 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Here we present a biomimetic strategy towards an influenza vaccine design based on hepatitis B virus core virus-like particles (HBc VLP). To this end, a temperature-shift based encapsulation process based ...
Shah S, McManus D, Bejou N, et al. Clinical outcomes of baloxavir versus oseltamivir in patients hospitalized with influenza A. J Antimicrob Chemother. 2020;dkaa252. Abstract
submitted by kickingbird at Jul, 28, 2020 from J Antimicrob Chemother. 2020;dkaa252 (via https://pubmed.ncbi.nlm.nih.gov/32712669/)
Objectives: To date, clinical trials evaluating baloxavir have excluded patients hospitalized with influenza infection and therefore this study sought to evaluate the efficacy of baloxavir in inpatients ...
Ayim-Akonor M, Mertens E, May J, Harder T. Exposure of domestic swine to influenza A viruses in Ghana suggests unidirectional, reverse zoonotic transmission at the human-animal interface. Zoonoses Public Health. 2020;10.1111/zph.12751. Abstract
submitted by kickingbird at Jul, 27, 2020 from Zoonoses Public Health. 2020;10.1111/zph.12751 (via https://pubmed.ncbi.nlm.nih.gov/32710707/)
Influenza A viruses (IAVs) have both zoonotic and anthroponotic potential and are of public and veterinary importance. Swine are intermediate hosts and 'mixing vessels' for generating reassortants, progenies ...
van der Woude R, Turner HL, Tomris I, Bouwman KM,. Drivers of recombinant soluble influenza A virus hemagglutinin and neuraminidase expression in mammalian cells. Protein Sci. 2020;10.1002/pro.3918.. Abstract
submitted by kickingbird at Jul, 27, 2020 from Protein Sci. 2020;10.1002/pro.3918. (via https://pubmed.ncbi.nlm.nih.gov/32710576/)
Recombinant soluble trimeric influenza A virus hemagglutinins (HA) and tetrameric neuraminidases (NA) have proven to be excellent tools to decipher biological properties. Receptor binding and sialic acid ...
Hobbelen PHF, Elbers ARW, Werkman M, et al. Estimating the introduction time of highly pathogenic avian influenza into poultry flocks. Sci Rep . 2020 Jul 24;10(1):12388. Abstract
submitted by kickingbird at Jul, 27, 2020 from Sci Rep . 2020 Jul 24;10(1):12388 (via https://pubmed.ncbi.nlm.nih.gov/32709965/)
The estimation of farm-specific time windows for the introduction of highly-pathogenic avian influenza (HPAI) virus can be used to increase the efficiency of disease control measures such as contact tracing ...
Nguyen NM, Sung HW, Yun KJ, Park H, Yeo SJ. Genetic Characterization of a Novel North American-Origin Avian Influenza A (H6N5) Virus Isolated from Bean Goose of South Korea in 2018. Viruses. 2020;12(7):E774.. Abstract
submitted by kickingbird at Jul, 27, 2020 from Viruses. 2020;12(7):E774. (via https://pubmed.ncbi.nlm.nih.gov/32709116/)
The complex overlap in waterfowl migratory pathways across the world has established numerous occurrences of genetic reassortment and intercontinental spread of avian influenza virus (AIV) over long distances, ...
Wang S, Liang T, Luo Q, et al. H9N2 swine influenza virus infection-induced damage is mediated by TRPM2 channels in mouse pulmonary microvascular endothelial cells. Microb Pathog. 2020;104408. Abstract
submitted by kickingbird at Jul, 27, 2020 from Microb Pathog. 2020;104408 (via https://www.sciencedirect.com/science/article/abs/pii/S08824)
Oxidative stress is implicated in the pathogenesis of influenza virus infection. Increasing evidences show that transient receptor potential melastatin 2 (TRPM2), a Ca2+-permeable non-selective cation ...
Sun Y, Zhang K, Qi H, et al. Computational Predicting the Human Infectivity of H7N9 Influenza Viruses Isolated from Avian Hosts. ransbound Emerg Dis. 2020;10.1111/tbed.13750. Abstract
submitted by kickingbird at Jul, 27, 2020 from ransbound Emerg Dis. 2020;10.1111/tbed.13750 (via https://pubmed.ncbi.nlm.nih.gov/32706427/)
The genome composition of a given avian influenza virus is the primary determinant of its potential for cross-species transmission from birds to humans. Here we introduce a viral genome-based computational ...
Bueno de Mesquita PJ, Nguyen-Van-Tam J, Killingley. Influenza A (H3) illness and viral aerosol shedding from symptomatic naturally infected and experimentally infected cases. Influenza Other Respir Viruses. 2020;10.1111/irv.1. Abstract
submitted by kickingbird at Jul, 27, 2020 from Influenza Other Respir Viruses. 2020;10.1111/irv.1 (via https://pubmed.ncbi.nlm.nih.gov/32705798/)
Background: It has long been known that nasal inoculation with influenza A virus produces asymptomatic to febrile infections. Uncertainty persists about whether these infections are sufficiently similar ...
Lee YN, Lee DH, Cheon SH, et al. Genetic characteristics and pathogenesis of H5 low pathogenic avian influenza viruses from wild birds and domestic ducks in South Korea. Sci Rep. 2020;10(1):12151. Abstract
submitted by kickingbird at Jul, 27, 2020 from Sci Rep. 2020;10(1):12151 (via https://pubmed.ncbi.nlm.nih.gov/32699272/)
H5 and H7 subtypes of low pathogenic avian influenza viruses (LPAIVs) can mutate to highly pathogenic forms and are therefore subject to stringent controls. We characterized H5 LPAIVs isolated from wild-bird ...
Cui Y, Li Y, Li M, et al. Evolution and extensive reassortment of H5 influenza viruses isolated from wild birds in China over the past decade. Emerg Microbes Infect. 2020;1-0. Abstract
submitted by kickingbird at Jul, 21, 2020 from Emerg Microbes Infect. 2020;1-0 (via https://pubmed.ncbi.nlm.nih.gov/32686602/)
Lethal infection of wild birds with different subtypes of H5 viruses continuously occur. To investigate the genetic evolution and pathogenicity of H5 viruses in wild birds, we performed a detailed genetic ...
Yang CR, King CC, Liu LD, Ku CC. FluConvert and IniFlu: a suite of integrated software to identify novel signatures of emerging influenza viruses with increasing risk. BMC Bioinformatics. 2020;21(1):316. Abstract
submitted by kickingbird at Jul, 20, 2020 from BMC Bioinformatics. 2020;21(1):316 (via https://pubmed.ncbi.nlm.nih.gov/32682392/)
Background: The pandemic threat of influenza has attracted great attention worldwide. To assist public health decision-makers, new suites of tools are needed to rapidly process and combine viral information ...
Barberis A, Boudaoud A, Gorrill A, et al. Full-length genome sequences of the first H9N2 avian influenza viruses isolated in the Northeast of Algeria. Virol J. 2020;17(1):108. Abstract
submitted by kickingbird at Jul, 20, 2020 from Virol J. 2020;17(1):108 (via https://pubmed.ncbi.nlm.nih.gov/32680533/)
Background: H9N2 avian influenza viruses (AIV) has a worldwide geographic distribution and affects poultry of different types of production. H9N2 AIV was first reported in the Northeast of Algeria in April ...
Zell R, Groth M, Krumhbolz A, Lange J, Philipps A,. Cocirculation of Swine H1N1 Influenza A Virus Lineages in Germany. Viruses. 2020;12(7):E762. Abstract
submitted by kickingbird at Jul, 19, 2020 from Viruses. 2020;12(7):E762 (via https://pubmed.ncbi.nlm.nih.gov/32679903/)
The genome analysis of 328 H1N1 swine influenza virus isolates collected in a 13-year long-term swine influenza surveillance in Germany is reported. Viral genomes were sequenced with the Illumina next-generation ...
Liao HY, Wang SC, Ko YA, et al. Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes. Proc Natl Acad Sci U S A. 2020;202004783. Abstract
submitted by kickingbird at Jul, 18, 2020 from Proc Natl Acad Sci U S A. 2020;202004783 (via https://pubmed.ncbi.nlm.nih.gov/32669430/)
Vaccination has been used to control the spread of seasonal flu; however, the virus continues to evolve and escape from host immune response through mutation and increasing glycosylation. Efforts have ...
Wei J, Li Z, Yang Y, Ma G, Su Z, Zhang S. An apoferritin-haemagglutinin conjugate vaccine with encapsulated nucleoprotein antigen peptide from influenza virus confers enhanced cross protection. Bioconjug Chem. 2020;10.1021/acs.bioconjchem.0c00. Abstract
submitted by kickingbird at Jul, 18, 2020 from Bioconjug Chem. 2020;10.1021/acs.bioconjchem.0c00 (via https://pubmed.ncbi.nlm.nih.gov/32678574/)
Naturally occurring self-assembling ferritin nanoparticles have become widely appreciated for vaccine design. In this study, an apoferritin (AFt) nanocage was used as a carrier to construct a biomimetic ...
Ge Z, Gu M, Cai T, et al. Phylogenetic tracing and biological characterization of a novel clade 126.96.36.199 reassortant of H5N6 subtype avian influenza virus in China. Transbound Emerg Dis. 2020;10.1111/tbed.13736. Abstract
submitted by kickingbird at Jul, 18, 2020 from Transbound Emerg Dis. 2020;10.1111/tbed.13736 (via https://pubmed.ncbi.nlm.nih.gov/32677729/)
In recent years in China, clade 188.8.131.52 H5N6 plus clade 184.108.40.206 H5N1 subtype highly pathogenic avian influenza (HPAI) viruses have gradually become endemic in poultry, and their co-circulation could inevitably ...
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