Zeng H, et al. Tropism and Infectivity of a Seasonal A(H1N1) and a Highly Pathogenic Avian A(H5N1) Influenza Virus in Primary Differentiated Ferret Nasal Epithelial Cell Cultures. J Virol. 2019 Feb 27.. Abstract
submitted by kickingbird at Mar, 1, 2019 from J Virol. 2019 Feb 27. (via https://jvi.asm.org/content/early/2019/02/22/JVI.00080-19)
Ferrets represent an invaluable animal model to study influenza virus pathogenesis and transmission. To further characterize this model, we developed a differentiated primary ferret nasal epithelial cell ...
Tang YS, Lo CY, Mok CK, Chan PK, Shaw PC. The extended C-terminal region of influenza C nucleoprotein is important for nuclear import and RNP activity. J Virol. 2019 Feb 27. Abstract
submitted by kickingbird at Mar, 1, 2019 from J Virol. 2019 Feb 27 (via https://jvi.asm.org/content/early/2019/02/22/JVI.02048-18)
The influenza C virus (ICV) is a human pathogenic agent and the infections are frequently identified in children. Compared to influenza A and B viruses, the nucleoprotein of ICV (NPC) has an extended C-terminal ...
Lu Y, et al. In Vivo Characterization of Avian Influenza A (H5N1) and (H7N9) Viruses Isolated from Canadian Travelers. Viruses. 2019 Feb 23;11(2).. Abstract
submitted by kickingbird at Mar, 1, 2019 from Viruses. 2019 Feb 23;11(2). (via https://www.mdpi.com/1999-4915/11/2/193)
Highly pathogenic avian influenza (HPAI) H5N1 and low pathogenic avian influenza (LPAI) H7N9 viruses pose a severe threat to public health through zoonotic infection, causing severe respiratory disease ...
Blanco-Lobo P, Nogales A, Rodríguez L, etc al. Novel Approaches for The Development of Live Attenuated Influenza Vaccines. Viruses. 2019 Feb 22;11(2).. Abstract
submitted by kickingbird at Mar, 1, 2019 from Viruses. 2019 Feb 22;11(2). (via https://www.mdpi.com/1999-4915/11/2/190)
Influenza virus still represents a considerable threat to global public health, despite the advances in the development and wide use of influenza vaccines. Vaccination with traditional inactivate influenza ...
Li Z, Fu J, Lin G, Jiang D. Spatiotemporal Variation and Hotspot Detection of the Avian Influenza A(H7N9) Virus in China, 2013~2017. Int J Environ Res Public Health. 2019 Feb 22;16(4). Abstract
submitted by kickingbird at Mar, 1, 2019 from Int J Environ Res Public Health. 2019 Feb 22;16(4) (via https://www.mdpi.com/1660-4601/16/4/648)
This study aims to describe the spatial and temporal characteristics of human infections with H7N9 virus in China using data from 19 February 2013 to 30 September 2017 extracted from Centre for Health ...
Kissling E, et al. Interim 2018/19 influenza vaccine effectiveness: six European studies, October 2018 to January 2019. Euro Surveill. 2019 Feb;24(8).. Abstract
submitted by kickingbird at Feb, 28, 2019 from Euro Surveill. 2019 Feb;24(8). (via https://www.eurosurveillance.org/content/10.2807/1560-7917.E)
Influenza A(H1N1)pdm09 and A(H3N2) viruses both circulated in Europe in October 2018-January 2019. Interim results from six studies indicate that 2018/19 influenza vaccine effectiveness (VE) estimates ...
Corbett KS, et al. Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages. MBio. 2019 Feb 26;10(1).. Abstract
submitted by kickingbird at Feb, 28, 2019 from MBio. 2019 Feb 26;10(1). (via https://mbio.asm.org/content/10/1/e02810-18)
Influenza vaccines targeting the highly conserved stem of the hemagglutinin (HA) surface glycoprotein have the potential to protect against pandemic and drifted seasonal influenza viruses not covered by ...
Kramer SC, Shaman J. Development and validation of influenza forecasting for 64 temperate and tropical countries. PLoS Comput Biol. 2019 Feb 27;15(2):e1006742.. Abstract
submitted by kickingbird at Feb, 28, 2019 from PLoS Comput Biol. 2019 Feb 27;15(2):e1006742. (via https://journals.plos.org/ploscompbiol/article?id=10.1371/jo)
Accurate forecasts of influenza incidence can be used to inform medical and public health decision-making and response efforts. However, forecasting systems are uncommon in most countries, with a few notable ...
Farsakoglu Y, et al. Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner. Cell Rep. 2019 Feb 26;26(9):2307-2315.e5. Abstract
submitted by kickingbird at Feb, 28, 2019 from Cell Rep. 2019 Feb 26;26(9):2307-2315.e5 (via https://www.cell.com/cell-reports/fulltext/S2211-1247(19)301)
The role of natural killer (NK) cells in the immune response against vaccines is not fully understood. Here, we examine the function of infiltrated NK cells in the initiation of the inflammatory response ...
Klifa R, et al. Influenza vaccination among children with idiopathic nephrotic syndrome: an investigation of practices. BMC Nephrol. 2019 Feb 25;20(1):65.. Abstract
submitted by kickingbird at Feb, 27, 2019 from BMC Nephrol. 2019 Feb 25;20(1):65. (via https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882)
BACKGROUND: Annual influenza vaccination is recommended for all children with idiopathic nephrotic syndrome (INS) in France. Consequently, the Social Security automatically sends prescriptions to all patients ...
Rich HE, et al. Interferon Lambda Inhibits Bacterial Uptake During Influenza Super-Infection. Infect Immun. 2019 Feb 25. Abstract
submitted by kickingbird at Feb, 27, 2019 from Infect Immun. 2019 Feb 25 (via https://iai.asm.org/content/early/2019/02/22/IAI.00114-19)
Influenza kills 30-40,000 people each year in the United States, and causes ten times as many hospitalizations. A common complication of influenza is bacterial super-infection, which exacerbates morbidity ...
Jorquera PA, et al. Insights into the antigenic advancement of influenza A(H3N2) viruses, 2011~2018. Sci Rep. 2019 Feb 25;9(1):2676.. Abstract
submitted by kickingbird at Feb, 27, 2019 from Sci Rep. 2019 Feb 25;9(1):2676. (via https://www.nature.com/articles/s41598-019-39276-1)
Influenza A(H3N2) viruses evade human immunity primarily by acquiring antigenic changes in the haemagglutinin (HA). HA receptor-binding features of contemporary A(H3N2) viruses hinder traditional antigenic ...
Holzer B, Martini V, Edmans M, Tchilian E. T and B Cell Immune Responses to Influenza Viruses in Pigs. Front Immunol. 2019 Feb 5;10:98.. Abstract
submitted by kickingbird at Feb, 27, 2019 from Front Immunol. 2019 Feb 5;10:98. (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0009)
Influenza viruses are an ongoing threat to humans and are endemic in pigs, causing considerable economic losses to farmers. Pigs are also a source of new viruses potentially capable of initiating human ...
Worobey M, Cox J, Gill D. The origins of the great pandemic. Evol Med Public Health. 2019 Jan 21;2019(1):18-25. Abstract
submitted by kickingbird at Feb, 27, 2019 from Evol Med Public Health. 2019 Jan 21;2019(1):18-25 (via https://academic.oup.com/emph/article/2019/1/18/5298310)
The timing and location of the first cases of the 1918 influenza pandemic are still controversial, a century after the pandemic became widely recognized. Here, we critically review competing hypotheses ...
Abusrewil S, et al. Influenza surveillance in Middle East, North, East and South Africa: Report of the 8th MENA Influenza Stakeholders Network. Influenza Other Respir Viruses. 2019 Feb 22.. Abstract
submitted by kickingbird at Feb, 27, 2019 from Influenza Other Respir Viruses. 2019 Feb 22. (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12628)
The Middle-East and Africa Influenza Surveillance Network (MENA-ISN), established in 2014, includes 15 countries at present. Country representatives presented their influenza surveillance programmes, vaccine ...
McGee CE, et al. Influenza-Mediated Lung Infection Models. Methods Mol Biol. 2019;1960:191-205.. Abstract
submitted by kickingbird at Feb, 27, 2019 from Methods Mol Biol. 2019;1960:191-205. (via https://www.ncbi.nlm.nih.gov/pubmed/30798533)
Laboratory rodent influenza infection models have been and continue to be a critical tool for understanding virus-host interactions during infection. The incidence of seasonal influenza infections coupled ...
Wang Z, et al. Enhanced cross-lineage protection induced by recombinant H9N2 avian influenza virus inactivated vaccine. Vaccine. 2019 Feb 20.. Abstract
submitted by kickingbird at Feb, 25, 2019 from Vaccine. 2019 Feb 20. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
BACKGROUND: Antigenic drift of H9N2 low pathogenic avian influenza viruses (AIV) may result in vaccination failure in the poultry industry and thus a cross-protective vaccine against H9N2 AIV is highly ...
Su K, et al. Influenza A(H7N9) virus emerged and resulted in human infections in Chongqing, southwestern China since 2017. Int J Infect Dis. 2019 Feb 21. Abstract
submitted by kickingbird at Feb, 25, 2019 from Int J Infect Dis. 2019 Feb 21 (via https://www.ijidonline.com/article/S1201-9712(19)30075-X/pdf)
OBJECTIVES: Influenza A(H7N9) virus emerged and resulted in human infections in Chongqing, southwestern China since 2017. This study aimed to describe the epidemiological characteristics of the first epidemic ...
Morita A, et al. Nationwide survey of influenza-associated acute encephalopathy in Japanese adults. J Neurol Sci. 2019 Feb 10;399:101-107. Abstract
submitted by kickingbird at Feb, 25, 2019 from J Neurol Sci. 2019 Feb 10;399:101-107 (via https://www.jns-journal.com/article/S0022-510X(19)30065-6/fu)
BACKGROUND: Knowledge of adult patients with influenza-associated acute encephalopathy (IAE) is limited. We conducted a detailed survey to investigate the prevalence, clinical features, associated outcomes, ...
Rao GK, et al. In Vivo Assessment of Antibody-Dependent Enhancement of Influenza B Infection. Toxicol Sci. 2019 Feb 22.. Abstract
submitted by kickingbird at Feb, 24, 2019 from Toxicol Sci. 2019 Feb 22. (via https://academic.oup.com/toxsci/advance-article-abstract/doi)
A theoretical safety concern proposed in the influenza literature is that therapeutic anti-viral antibodies could have the potential for antibody-dependent enhancement (ADE) of infection and disease. ADE ...
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