Tran V, Ledwith MP, Thamamongood T, et al. Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs. Nat Microbiol. 2020;10.1038/s41564-020-0778-x. Abstract
submitted by kickingbird at Aug, 26, 2020 from Nat Microbiol. 2020;10.1038/s41564-020-0778-x (via https://www.nature.com/articles/s41564-020-0778-x)
Cells infected by influenza virus mount a large-scale antiviral response and most cells ultimately initiate cell-death pathways in an attempt to suppress viral replication. We performed a CRISPR-Cas9-knockout ...
Lou J, Zhao S, Cao L, et al. Predicting the dominant influenza A serotype by quantifying mutation activities. Int J Infect Dis. 2020;S1201-9712(20)30682-2. Abstract
submitted by kickingbird at Aug, 26, 2020 from Int J Infect Dis. 2020;S1201-9712(20)30682-2 (via https://pubmed.ncbi.nlm.nih.gov/32841687/)
Objectives: Characterizing and predicting the evolutionary process of influenza, which remains challenging, are of importance in capturing the patterns of influenza activities and the development of prevention ...
Xu H, Qian J, Song Y, Ming D. The adaptability of H9N2 avian influenza A virus to humans: A comparative docking simulation study. Biochem Biophys Res Commun. 2020;529(4):963-969. Abstract
submitted by kickingbird at Aug, 25, 2020 from Biochem Biophys Res Commun. 2020;529(4):963-969 (via https://www.sciencedirect.com/science/article/abs/pii/S00062)
Influenza A virus, the H9N2 subtype, is an avian influenza virus that has long been circulating in the worldwide poultry industry and is occasionally found to be transmissible to humans. Evidence from ...
Gomaa MR, El Rifay AS, Abu Zeid D, et al. Incidence and Seroprevalence of Avian Influenza in a Cohort of Backyard Poultry Growers, Egypt, August 2015-March 2019. Emerg Infect Dis. 2020;26(9):2129-2136. Abstract
submitted by kickingbird at Aug, 25, 2020 from Emerg Infect Dis. 2020;26(9):2129-2136 (via https://wwwnc.cdc.gov/eid/article/26/9/20-0266_article.htm)
Currently enzootic avian influenza H5N1, H9N2, and H5N8 viruses were introduced into poultry in Egypt in 2006, 2011, and 2016, respectively. Infections with H5N1 and H9N2 were reported among poultry-exposed ...
Vandoorn E, Leroux-Roels I, Leroux-Roels G, Parys. Detection of H1 Swine Influenza A Virus Antibodies in Human Serum Samples by Age Group. Emerg Infect Dis. 2020;26(9):2118-2128. Abstract
submitted by kickingbird at Aug, 25, 2020 from Emerg Infect Dis. 2020;26(9):2118-2128 (via https://wwwnc.cdc.gov/eid/article/26/9/19-1796_article.htm)
Most H1 influenza A viruses (IAVs) of swine are derived from past human viruses. As human population immunity against these IAVs gradually decreases, the risk of reintroduction to humans increases. We ...
Li H, Li Q, Li B, et al. Continuous Reassortment of Clade 220.127.116.11 H5N6 Highly Pathogenetic Avian Influenza Viruses Demonstrating High Risk to Public Health. Pathogens. 2020;9(8):E670. Abstract
submitted by kickingbird at Aug, 25, 2020 from Pathogens. 2020;9(8):E670 (via https://www.mdpi.com/2076-0817/9/8/670)
Since it firstly emerged in China in 2013, clade 18.104.22.168 H5N6 highly pathogenic avian influenza viruses (HPAIVs) has rapidly replaced predominant H5N1 to become the dominant H5 subtype in China, especially ...
Gu J, Gu M, Yan Y, et al. Detection of PB2 627K mutation in two highly pathogenic isolates of the H7N9 subtype influenza A virus from chickens in northern China. J Infect. 2020;S0163-4453(20)30558-2. Abstract
submitted by kickingbird at Aug, 25, 2020 from J Infect. 2020;S0163-4453(20)30558-2 (via https://pubmed.ncbi.nlm.nih.gov/32828821/)
PB2 E627K mutation of influenza A virus has been considered relevant to increased mammalian virulence and adaptation. In H7N9, the substitution is naturally confined to most human isolates and few low ...
Hopken MW, Piaggio AJ, Pabilonia KL, et al. Population genomic transformations induced by isolation of wild bird avian influenza viruses (Orthomyxoviridae) in embryonated chicken eggs. Infect Genet Evol. 2020;104505. Abstract
submitted by kickingbird at Aug, 25, 2020 from Infect Genet Evol. 2020;104505 (via https://pubmed.ncbi.nlm.nih.gov/32827730/)
Isolation and cultivation of wild-type viruses in model organism cells or tissues is standard practice in virology. Oftentimes, the virus host species is distantly related to the species from which the ...
Nilsson K, Abdurahman S, Schwartz S. Influenza virus natural sequence heterogeneity in segment 8 affects interactions with cellular RNA-binding proteins and splicing efficiency. Virology. 2020;549:39-50. Abstract
submitted by kickingbird at Aug, 25, 2020 from Virology. 2020;549:39-50 (via https://pubmed.ncbi.nlm.nih.gov/32829114/)
Segment 8 mRNAs of influenza virus A/Brevig Misson/1918/1 (H1N1) are poorly spliced compared to segment 8 mRNAs of influenza virus A/Netherlands/178/95 (H3N2). Using oligonucleotide-mediated protein pull ...
Asadi S, Gaaloul Ben Hnia N, Barre RS, Wexler AS,. Influenza A virus is transmissible via aerosolized fomites. Nat Commun. 2020;11(1):4062.. Abstract
submitted by kickingbird at Aug, 21, 2020 from Nat Commun. 2020;11(1):4062. (via https://www.nature.com/articles/s41467-020-17888-w)
Influenza viruses are presumed, but not conclusively known, to spread among humans by several possible routes. We provide evidence of a mode of transmission seldom considered for influenza: airborne virus ...
Xie J, Pang XL, Tarr GAM, et al. Influenza virus detection in the stool of children with acute gastroenteritis. J Clin Virol. 2020;131:104565. Abstract
submitted by kickingbird at Aug, 21, 2020 from J Clin Virol. 2020;131:104565 (via https://pubmed.ncbi.nlm.nih.gov/32810839/)
Objectives: To determine if the clinical characteristics of children with gastroenteritis and influenza identified in their stool differ from those whose stool was influenza-negative. Methods: Children ...
Liu YM, Chen HC, Chen YC, et al. miR-1975 serves as an indicator of clinical severity upon influenza infection. Eur J Clin Microbiol Infect Dis. 2020;10.1007/s100. Abstract
submitted by kickingbird at Aug, 21, 2020 from Eur J Clin Microbiol Infect Dis. 2020;10.1007/s100 (via https://pubmed.ncbi.nlm.nih.gov/32814996/)
Emerging evidence highlights the role of non-coding small RNAs in host-influenza interaction. We have identified a Y RNA-derived small RNA, miR-1975, which is upregulated upon influenza A virus infection ...
Shubina M, Tummers B, Boyd DF, et al. Necroptosis restricts influenza A virus as a stand-alone cell death mechanism. J Exp Med. 2020;217(11):e20191259. Abstract
submitted by kickingbird at Aug, 18, 2020 from J Exp Med. 2020;217(11):e20191259 (via https://pubmed.ncbi.nlm.nih.gov/32797196/)
Influenza A virus (IAV) activates ZBP1-initiated RIPK3-dependent parallel pathways of necroptosis and apoptosis in infected cells. Although mice deficient in both pathways fail to control IAV and succumb ...
Patel MC, Mishin VP, De La Cruz JA, et al. Detection of baloxavir resistant influenza A viruses using next generation sequencing and pyrosequencing methods. Antiviral Res. 2020;104906. Abstract
submitted by kickingbird at Aug, 18, 2020 from Antiviral Res. 2020;104906 (via https://pubmed.ncbi.nlm.nih.gov/32798601/)
Baloxavir, a new antiviral drug targeting cap-dependent endonuclease activity of polymerase acidic (PA) protein of influenza viruses, is now approved in multiple countries. Several substitutions at isoleucine ...
Jiang W, Li Z, Liu S, et al. Genetic characterization of a highly pathogenic H5N6 avian influenza virus isolated from greylag goose. J Infect. 2020;S0163-4453(20)30550-8. Abstract
submitted by kickingbird at Aug, 18, 2020 from J Infect. 2020;S0163-4453(20)30550-8 (via https://pubmed.ncbi.nlm.nih.gov/32800799/)
We isolated and characterized a highly pathogenic H5N6 avian influenza virus in wild birds during avian influenza virus surveillance in 2020. The GG1/H5N6 virus was highly pathogenic. Several mutations ...
Yuyun I, Wibawa H, Setiaji G, Kusumastuti TA, Nugr. Determining highly pathogenic H5 avian influenza clade 22.214.171.124c seroprevalence in ducks, Purbalingga, Central Java, Indonesia. Vet World . 2020 Jun;13(6):1138-1144. Abstract
submitted by kickingbird at Aug, 18, 2020 from Vet World . 2020 Jun;13(6):1138-1144 (via https://pubmed.ncbi.nlm.nih.gov/32801565/)
Background and aim: In Indonesia, highly pathogenic avian influenza (HPAI) H5N1 outbreaks in poultry are still reported. The disease causes a decrease in egg production and an increase in mortality; this ...
Weinan Zheng, et al. Nucleoprotein phosphorylation site (Y385) mutation confers temperature sensitivity to influenza A virus due to impaired nucleoprotein oligomerization at a lower temperature. Sci China Life Sci . 2020 Aug 11. Abstract
submitted by kickingbird at Aug, 18, 2020 from Sci China Life Sci . 2020 Aug 11 (via https://pubmed.ncbi.nlm.nih.gov/32803713/)
Mutations in viral proteins can lead to the cold adaption of influenza A virus and the cold-adapted virus is an important vaccination instrument. Here, we identify a novel strain of influenza A virus with ...
Ming Zhong, et al. Amide-sialoside protein conjugates as neomucin bioshields prevent influenza virus infection. Carbohydr Res . 2020 Sep;495:108088.. Abstract
submitted by kickingbird at Aug, 18, 2020 from Carbohydr Res . 2020 Sep;495:108088. (via https://pubmed.ncbi.nlm.nih.gov/32807356/)
We report the preparation of multivalent amide-sialoside-decorated human serum albumin (HSA) and bovine serum albumin (BSA) as mimics of natural mucin and bioshields against influenza virus infection. ...
Sirawan A, Berry A, Badra R, et al. Avian influenza surveillance at the human-animal interface in Lebanon, 2017. East Mediterr Health J. 2020;26(7):774-778. Abstract
submitted by kickingbird at Aug, 17, 2020 from East Mediterr Health J. 2020;26(7):774-778 (via https://pubmed.ncbi.nlm.nih.gov/32794162/)
Background: Avian influenza viruses (AIVs) cause severe diseases in poultry and humans. In Lebanon, AIV H9N2 was detected in 2006 and 2010 and H5N1 was detected in 2016. Aim: To evaluate the current circulating ...
Zhang M, Zhao C, Chen H, et al. Internal Gene Cassette From a Human-Origin H7N9 Influenza Virus Promotes the Pathogenicity of H9N2 Avian Influenza Virus in Mice. Front Microbiol. 2020;11:1441. Abstract
submitted by kickingbird at Aug, 17, 2020 from Front Microbiol. 2020;11:1441 (via https://pubmed.ncbi.nlm.nih.gov/32793127/)
H9N2 avian influenza virus is one of the most widely circulating viruses in poultry and poses a huge potential threat to human health due to its frequent gene reassortment with other influenza viruses. ...
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