Schreiber A, et al. Type I interferon antagonistic properties of Influenza B virus polymerase proteins. Cell Microbiol. 2019 Nov 11:e13143. Abstract
submitted by kickingbird at Nov, 14, 2019 from Cell Microbiol. 2019 Nov 11:e13143 (via https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.13143)
The innate immune system, in particular the type I interferon (IFN) response, is a powerful defense against virus infections. In turn, many if not all viruses have evolved various means to circumvent, ...
Antanasijevic A, Durst MA, Lavie A, Caffrey M. Identification of a pH Sensor in Influenza Hemagglutinin using X-ray Crystallography. J Struct Biol. 2019 Nov 2:107412. Abstract
submitted by kickingbird at Nov, 11, 2019 from J Struct Biol. 2019 Nov 2:107412 (via https://www.ncbi.nlm.nih.gov/pubmed/31689502)
Hemagglutnin (HA) mediates entry of influenza virus through a series of conformational changes triggered by the low pH of the endosome. The residue or combination of residues acting as pH sensors has not ...
Kwon HI, et al. A Novel Neuraminidase-Dependent Hemagglutinin Cleavage Mechanism Enables the Systemic Spread of an H7N6 Avian Influenza Virus. MBio. 2019 Nov 5;10(6). Abstract
submitted by kickingbird at Nov, 11, 2019 from MBio. 2019 Nov 5;10(6) (via https://mbio.asm.org/content/10/6/e02369-19)
n this study, we demonstrate a novel mechanism for hemagglutinin (HA) activation in a naturally occurring H7N6 avian influenza A virus strain, A/mallard duck/Korea/6L/2007 (A/Mdk/6L/07). This novel mechanism ...
Seki M, Sakai-Tagawa Y, Yasuhara A, Watanabe Y. Adult influenza A (H3N2) with reduced susceptibility to baloxavir or peramivir cured after switching anti-influenza agents. IDCases. 2019 Oct 1;18:e00650.. Abstract
submitted by kickingbird at Nov, 11, 2019 from IDCases. 2019 Oct 1;18:e00650. (via https://www.ncbi.nlm.nih.gov/pubmed/31692637)
We describe two adults with A/H3N2 influenza with (patient 1), and without (patient 2) polymerase acidic (PA) subunit I38?T substitution during the same season. Patient 1 had a reduced clinical response ...
Coombs KM, et al. Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses. Viruses. 2019 Nov 5;11(11).. Abstract
submitted by kickingbird at Nov, 11, 2019 from Viruses. 2019 Nov 5;11(11). (via https://www.mdpi.com/1999-4915/11/11/1028)
Influenza A viruses (IAVs) are important animal and human emerging and re-emerging pathogens that are responsible for yearly seasonal epidemics and sporadic pandemics. IAVs cause a wide range of clinical ...
Gambaryan AS, et al. Changes in the Receptor-Binding Properties of H3N2 Viruses during Long-Term Circulation in Humans. Biochemistry (Mosc). 2019 Oct;84(10):1177-1185. Abstract
submitted by kickingbird at Nov, 11, 2019 from Biochemistry (Mosc). 2019 Oct;84(10):1177-1185 (via https://www.ncbi.nlm.nih.gov/pubmed/31694513)
It was previously shown that hemagglutinin residues Thr155, Glu158, and Ser228 are crucial for the recognition of Neu5Gc. In this study, we demonstrated that the ability to bind the Neu5Gc-terminated receptor ...
Brown JC, Barclay WS, Galiano M, Harvey R. Passage of influenza A/H3N2 viruses in human airway cells removes artefactual variants associated with neuraminidase-mediated binding. J Gen Virol. 2019 Nov 8.. Abstract
submitted by kickingbird at Nov, 11, 2019 from J Gen Virol. 2019 Nov 8. (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Serological assays with modern influenza A/H3N2 viruses have become problematic due to the progressive reduction in the ability of viruses of this subtype to bind and agglutinate red blood cells (RBCs). ...
Chen F, Liu T, Xu J, Huang Y, Liu S, Yang J. Key amino acid residues of neuraminidase involved in influenza A virus entry. Pathog Dis. 2019 Nov 8.. Abstract
submitted by kickingbird at Nov, 11, 2019 from Pathog Dis. 2019 Nov 8. (via https://academic.oup.com/femspd/advance-article-abstract/doi)
Generally, influenza virus neuraminidase (NA) plays a critical role in the release stage of influenza virus. Recently, it has been found that NA may promote influenza virus to access the target cells. ...
Baek YG, et al. A novel reassortant clade 188.8.131.52 highly pathogenic avian influenza H5N6 virus identified in South Korea in 2018. Infect Genet Evol. 2019 Nov 1:104056.. Abstract
submitted by kickingbird at Nov, 7, 2019 from Infect Genet Evol. 2019 Nov 1:104056. (via https://www.ncbi.nlm.nih.gov/pubmed/31683010)
Since 2017, clade 184.108.40.206b H5N6 highly pathogenic avian influenza viruses (HPAIVs) have been detected over a broad geographic region, including Eurasia. These viruses have evolved through reassortment ...
Tapia F, Laske T, Wasik MA, Rammhold M, Genzel Y. Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times-Insights From qPCR Measurements and Viral Dynamics Modeling. Front Bioeng Biotechnol. 2019 Oct 18;7:275. Abstract
submitted by kickingbird at Nov, 7, 2019 from Front Bioeng Biotechnol. 2019 Oct 18;7:275 (via https://www.frontiersin.org/articles/10.3389/fbioe.2019.0027)
Defective interfering particles (DIPs) are a natural byproduct of influenza A virus (IAV) replication. DIPs interfere with the propagation and spread of infectious standard virus (STV), reduce virus yields ...
Zhang F, et al. Phenotypic Characterization of Chinese Rhesus Macaque Plasmablasts for Cloning Antigen-Specific Monoclonal Antibodies. Front Immunol. 2019 Oct 11;10:2426. Abstract
submitted by kickingbird at Nov, 7, 2019 from Front Immunol. 2019 Oct 11;10:2426 (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0242)
Rhesus macaques (Macaca mulatta) are used as a human-relevant animal species for the evaluation of vaccines and as a source for cloning monoclonal antibodies (mAbs) that are highly similar to human-derived ...
Li J, Zhang K, Fan W, Zhang S, Li Y, Gu J, Zhou J,. Transcriptome Profiling Reveals Differential Effect of Interleukin-17A Upon Influenza Virus Infection in Human Cells. Front Microbiol. 2019 Oct 10;10:2344.. Abstract
submitted by kickingbird at Nov, 7, 2019 from Front Microbiol. 2019 Oct 10;10:2344. (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0234)
Influenza A virus (IAV) has developed elegant strategies to utilize cellular proteins and pathways to promote replication and evade the host antiviral response. Identification of these sabotaged host factors ...
Sakai-Tagawa Y, Yamayoshi S, Kawaoka Y. Sensitivity of Commercially Available Influenza Rapid Diagnostic Tests in the 2018-2019 Influenza Season. Front Microbiol. 2019 Oct 11;10:2342.. Abstract
submitted by kickingbird at Nov, 7, 2019 from Front Microbiol. 2019 Oct 11;10:2342. (via https://www.frontiersin.org/articles/10.3389/fmicb.2019.0234)
Epidemics of seasonal influenza caused by H1N1pdm09, H3N2, and type B viruses occur throughout the world. Sporadic human H5 and H7N9 virus infections are also reported in particular regions. To treat influenza ...
Yang J, Li H, Jia L, Lan X, Zhao Y, Bian H, Li Z. High expression levels of influenza virus receptors in airway of the HBV-transgenic mice. Epidemiol Infect. 2019 Nov 4;147:e297.. Abstract
submitted by kickingbird at Nov, 7, 2019 from Epidemiol Infect. 2019 Nov 4;147:e297. (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
In the human population, influenza A viruses are associated with acute respiratory illness and are responsible for millions of deaths annually. Avian and human influenza viruses typically have a different ...
Ampomah PB, Lim LHK. Influenza A virus-induced apoptosis and virus propagation. Apoptosis. 2019 Oct 30. Abstract
submitted by kickingbird at Nov, 3, 2019 from Apoptosis. 2019 Oct 30 (via https://www.ncbi.nlm.nih.gov/pubmed/31667646)
Influenza A viruses (IAVs) are respiratory pathogens that cause severe morbidity and mortality worldwide. They affect cellular processes such as proliferation, protein synthesis, autophagy, and apoptosis. ...
Uyeki TM, Peiris M. Novel Avian Influenza A Virus Infections of Humans. Infect Dis Clin North Am. 2019 Dec;33(4):907-932.. Abstract
submitted by kickingbird at Nov, 3, 2019 from Infect Dis Clin North Am. 2019 Dec;33(4):907-932. (via https://www.ncbi.nlm.nih.gov/pubmed/31668198)
A high index of suspicion and early diagnosis of avian influenza A virus infection is essential reduce transmission risk. Clinical suspicion relies on eliciting a history of recent exposure to poultry ...
Leonenko V, Bobashev G. Analyzing influenza outbreaks in Russia using an age-structured dynamic transmission model. Epidemics. 2019 Jul 22:100358.. Abstract
submitted by kickingbird at Nov, 3, 2019 from Epidemics. 2019 Jul 22:100358. (via https://www.ncbi.nlm.nih.gov/pubmed/31668495)
In this study, we addressed the ability of a minimalistic SEIR model to satisfactorily describe influenza outbreak dynamics in Russian settings. For that purpose, we calibrated an age-specific influenza ...
Kang YM, Cho HK, Kim HM, Lee MH, To TL, Kang HM. Protective efficacy of vaccines of the Korea national antigen bank against the homologous H5Nx clade 220.127.116.11 and clade 18.104.22.168 highly pathogenic avian influenza viruses. Vaccine. 2019 Oct 25. Abstract
submitted by kickingbird at Nov, 3, 2019 from Vaccine. 2019 Oct 25 (via https://www.ncbi.nlm.nih.gov/pubmed/31669062)
The occurrence of severe outbreaks of highly pathogenic avian influenza in Korea led to establishment of a national antigen bank for emergency preparedness. Here, we developed five vaccines for this bank ...
Ivan FX, et al. Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore. Int J Infect Dis. 2019 Oct 25. Abstract
submitted by kickingbird at Nov, 3, 2019 from Int J Infect Dis. 2019 Oct 25 (via https://www.ncbi.nlm.nih.gov/pubmed/31669593)
BACKGROUND: This study compared the genomes of influenza viruses that caused mild infections among outpatients and severe infections among hospitalized patients in Singapore, and characterized their molecular ...
Escuyer KL, E Fuschino M, St George K. New York State Emergency Preparedness and Response to Influenza Pandemics 1918-2018. Trop Med Infect Dis. 2019 Oct 30;4(4).. Abstract
submitted by kickingbird at Nov, 3, 2019 from Trop Med Infect Dis. 2019 Oct 30;4(4). (via https://www.mdpi.com/2414-6366/4/4/132)
Emergency health preparedness and response efforts are a necessity in order to safeguard the public against major events, such as influenza pandemics. Since posting warnings of the epidemic influenza in ...
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