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2019-8-19 10:41:44
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Wong JY, Goldstein E, Fang VJ, Cowling BJ, Wu P. Real-time estimation of the influenza-associated excess mortality in Hong Kong. Epidemiol Infect. 2019 Jan;147:e217.  Abstract  
submitted by kickingbird at Aug, 2, 2019 from Epidemiol Infect. 2019 Jan;147:e217 (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
Statistical models are commonly employed in the estimation of influenza-associated excess mortality that, due to various reasons, is often underestimated by laboratory-confirmed influenza deaths reported ...

Komadina N, et al. Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections. Epidemiol Infect. 2019 Jan;147:e213..  Abstract  
submitted by kickingbird at Aug, 2, 2019 from Epidemiol Infect. 2019 Jan;147:e213. (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
The epidemiology of H5N1 and H7N9 avian viruses of humans infected in China differs despite both viruses being avian reassortants that have inherited six internal genes from a common ancestor, H9N2. The ...

Lin RW, et al. Naturally occurring mutations in PB1 affect influenza A virus replication fidelity, virulence, and adaptability. J Biomed Sci. 2019 Jul 31;26(1):55.  Abstract  
submitted by kickingbird at Aug, 2, 2019 from J Biomed Sci. 2019 Jul 31;26(1):55 (via https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929)
BACKGROUND: Mutations in the PB1 subunit of RNA-dependent RNA polymerase (RdRp) of influenza A virus can affect replication fidelity. Before the influenza A/H1N1 pandemic in 2009, most human influenza ...

?wi?toń E, et al. Evolution of H9N2 low pathogenic avian influenza virus during passages in chickens. Infect Genet Evol. 2019 Jul 24:103979..  Abstract  
submitted by kickingbird at Jul, 30, 2019 from Infect Genet Evol. 2019 Jul 24:103979. (via https://www.sciencedirect.com/science/article/pii/S156713481)
The process of avian influenza virus (AIV) evolution in a new host was investigated in the experiment in which ten serial passages of a turkey-derived H9N2 AIV were carried out in specific pathogen free ...

Andrews SF, et al. Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin. Immunity. 2019 Jul 16.  Abstract  
submitted by kickingbird at Jul, 30, 2019 from Immunity. 2019 Jul 16 (via https://www.cell.com/immunity/fulltext/S1074-7613(19)30294-8)
Vaccine-induced memory B cell responses to evolving viruses like influenza A involve activation of pre-existing immunity and generation of new responses. To define the contribution of these two types of ...

Ng K, et al. Responses of human mast cells and epithelial cells following exposure to influenza A virus. Antiviral Res. 2019 Jul 23:104566.  Abstract  
submitted by kickingbird at Jul, 30, 2019 from Antiviral Res. 2019 Jul 23:104566 (via https://www.sciencedirect.com/science/article/pii/S016635421)
As a part of innate immune defense, the role of mast cells during viral replication has been incompletely understood. In this study, we characterized and compared the responses of the human mast cell line, ...

Wang J, et al. First outbreak of human infection with avian influenza A(H7N9) virus in Guangxi, China, 2016 to 2017. Chin Med J (Engl). 2019 Jul 24.  Abstract  
submitted by kickingbird at Jul, 30, 2019 from Chin Med J (Engl). 2019 Jul 24 (via https://insights.ovid.com/crossref?an=00029330-900000000-997)
First outbreak of human infection with avian influenza A(H7N9) virus in Guangxi, China, 2016 to 2017

Eickhoff CS, et al. Highly conserved influenza T cell epitopes induce broadly protective immunity. Vaccine. 2019 Jul 19.  Abstract  
submitted by kickingbird at Jul, 27, 2019 from Vaccine. 2019 Jul 19 (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Influenza world-wide causes significant morbidity and mortality annually, and more severe pandemics when novel strains evolve to which humans are immunologically na?ve. Because of the high viral mutation ...

Dadonaite B, et al. The structure of the influenza A virus genome. Nat Microbiol. 2019 Jul 22.  Abstract  
submitted by kickingbird at Jul, 27, 2019 from Nat Microbiol. 2019 Jul 22 (via https://www.nature.com/articles/s41564-019-0513-7)
Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA segments contained in separate viral ribonucleoprotein (vRNP) complexes ...

Schar D, et al. New frontiers in applied veterinary point-of-capture diagnostics: Toward early detection and control of zoonotic influenza. Influenza Other Respir Viruses. 2019 Jul 23.  Abstract  
submitted by kickingbird at Jul, 27, 2019 from Influenza Other Respir Viruses. 2019 Jul 23 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12648)
Among the chief limitations in achieving early detection and control of animal-origin influenza of pandemic potential in high-risk livestock populations is the existing lag time between sample collection ...

Li J, et al. Rapid isolation of a potent human antibody against H7N9 influenza virus from an infected patient. Antiviral Res. 2019 Jul 20;170:104564.  Abstract  
submitted by kickingbird at Jul, 27, 2019 from Antiviral Res. 2019 Jul 20;170:104564 (via https://www.sciencedirect.com/science/article/pii/S016635421)
Influenza virus A H7N9 remains a serious threat to public health due to the lack of effective vaccines and drugs. In this study, a neutralizing human antibody named 3L11 was rapidly isolated from the switched ...

Sangkachai N, et al. Serological evidence of influenza virus infection in captive wild felids, Thailand. J Vet Med Sci. 2019 Jul 23..  Abstract  
submitted by kickingbird at Jul, 27, 2019 from J Vet Med Sci. 2019 Jul 23. (via https://www.ncbi.nlm.nih.gov/pubmed/31341136)
Influenza virus is known to affect wild felids. To explore the prevalence of influenza viruses in these animal species, 196 archival sera from 5 felid species including Panthera tigris (N=147), Prionailurus ...

Jakubcová L, et al. Biological properties of influenza A virus mutants with amino acid substitutions in the HA2 glycoprotein of the HA1/HA2 interaction region. J Gen Virol. 2019 Jul 22..  Abstract  
submitted by kickingbird at Jul, 24, 2019 from J Gen Virol. 2019 Jul 22. (via https://jgv.microbiologyresearch.org/content/journal/jgv/10.)
Influenza A viruses (IAVs) enter into cells by receptor-dependent endocytosis. Subsequently, conformational changes of haemagglutinin are triggered by low environmental pH and the N terminus of HA2 glycoprotein ...

Xu L, et al. A Higher Rate of Pulmonary Fungal Infection in Chronic Obstructive Pulmonary Disease Patients with Influenza in a Large Tertiary Hospital. Respiration. 2019 Jul 22:1-10.  Abstract  
submitted by kickingbird at Jul, 24, 2019 from Respiration. 2019 Jul 22:1-10 (via https://www.karger.com/Article/Abstract/501410)
BACKGROUND: Influenza is considered a self-limiting disease. However, in patients with chronic obstructive pulmonary disease (COPD), it may result in serious outcomes during the flu season.OBJECTIVES: ...

Sun X, et al. Identification of key hemagglutinin residues responsible for cleavage, acid stability, and virulence of fifth-wave highly pathogenic avian influenza A(H7N9) viruses. Virology. 2019 Jul 12;535:232-240.  Abstract  
submitted by kickingbird at Jul, 22, 2019 from Virology. 2019 Jul 12;535:232-240 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
We previously demonstrated that despite no airborne transmissibility increase compared to low pathogenic avian influenza viruses, select human isolates of highly pathogenic avian influenza A(H7N9) virus ...

Hao X, et al. The PB2 and M genes of genotype S H9N2 virus contribute to the enhanced fitness of H5Nx and H7N9 avian influenza viruses in chickens. Virology. 2019 Jul 8;535:218-226.  Abstract  
submitted by kickingbird at Jul, 22, 2019 from Virology. 2019 Jul 8;535:218-226 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Genotype S H9N2 viruses frequently donate their internal genes to facilitate the generation of novel influenza viruses, e.g., H5N6, H7N9, and H10N8, which have caused human infection. Genotype S was originated ...

AlIbrahim M, et al. Molecular epidemiology and genetic characterization of influenza B virus in Lebanon during 2016~2018. Infect Genet Evol. 2019 Jul 17:103969.  Abstract  
submitted by kickingbird at Jul, 22, 2019 from Infect Genet Evol. 2019 Jul 17:103969 (via https://www.sciencedirect.com/science/article/pii/S156713481)
BACKGROUND: Influenza B viruses are a major cause of serious acute respiratory infections in humans.METHODS: Nasopharyngeal swabs were collected from subjects with influenza-like illness during October ...

Dahmani I, Ludwig K, Chiantia S. Influenza A matrix protein M1 induces lipid membrane deformation via protein multimerization. Biosci Rep. 2019 Jul 19.  Abstract  
submitted by kickingbird at Jul, 22, 2019 from Biosci Rep. 2019 Jul 19 (via http://bioscirep.org/lookup/doi/10.1042/BSR20191024)
The matrix protein M1 of the Influenza A virus is supposed to mediate viral assembly and budding at the plasma membrane (PM) of infected cells. In order for a new viral particle to form, the PM lipid bilayer ...

An J, Li J, Wang Y, Wang J, Li Q, Zhou H, et al. A Homeostasis Hypothesis of Avian Influenza Resistance in Chickens. Genes (Basel). 2019 Jul 17;10(7)..  Abstract  
submitted by kickingbird at Jul, 21, 2019 from Genes (Basel). 2019 Jul 17;10(7). (via https://www.mdpi.com/2073-4425/10/7/543)
Avian influenza has caused significant damage to the poultry industry globally. Consequently, efforts have been made to elucidate the disease mechanisms as well as the mechanisms of disease resistance. ...

Abed Y, et al. The Val430Ile neuraminidase (NA) substitution, identified in influenza B virus isolates, impacts the catalytic 116Arg residue causing reduced susceptibility to NA inhibitors. Antiviral Res. 2019 Jul 16:104561.  Abstract  
submitted by kickingbird at Jul, 21, 2019 from Antiviral Res. 2019 Jul 16:104561 (via https://www.sciencedirect.com/science/article/pii/S016635421)
As part of a 2015-2018 clinical trial of peramivir treatment for acute influenza infections in the elderly, an influenza B/Yamagata/16/1988-like isolate harbouring a Val430Ile neuraminidase (NA) substitution ...

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