LEE YT, Ko EJ, Lee Y, Lee YN, et al. CD47 plays a role as a negative regulator in inducing protective immune responses to vaccination against influenza virus. J Virol. 2016 May 18.. Abstract
submitted by kickingbird at May, 27, 2016 from J Virol. 2016 May 18. (via http://www.ncbi.nlm.nih.gov/pubmed/27194758)
An integrin-associated protein CD47, which is a ligand for the inhibitory receptor signal regulatory protein α, is expressed on B and T cells as well as on most innate immune cells. However, the roles ... KAMLANGDEE A, Kingstad-Bakke B, Osorio JE. Mosaic H5 hemagglutinin provides broad humoral and cellular immune responses against influenza viruses. J Virol. 2016 May 18. Abstract
submitted by kickingbird at May, 27, 2016 from J Virol. 2016 May 18 (via http://www.ncbi.nlm.nih.gov/pubmed/27194759)
The most effective way to prevent influenza infection is via vaccination. However, the constant mutation of influenza viruses due to antigenic drift and shift compromises vaccine efficacy. This represents ... FLANNERY B, Zimmerman RK, Gubareva LV, Garten RJ,. Enhanced genetic characterization of influenza A(H3N2) viruses and vaccine effectiveness by genetic group, 2014-2015. J Infect Dis. 2016 May 6.. Abstract
submitted by kickingbird at May, 27, 2016 from J Infect Dis. 2016 May 6. (via http://www.ncbi.nlm.nih.gov/pubmed/27190176)
BACKGROUND:
?During the 2014-15 US influenza season, expanded genetic characterization of circulating influenza A(H3N2) viruses was used to assess the impact of genetic variability of influenza A(H3N2) ... ABED Y, Bouhy X, L´Huillier AG, Rheaume C, e. The E119D neuraminidase mutation identified in a multidrug-resistant influenza A(H1N1)pdm09 isolate severely alters viral fitness in vitro and in animal models. Antiviral Res. 2016 May 13;132:6-12. Abstract
submitted by kickingbird at May, 27, 2016 from Antiviral Res. 2016 May 13;132:6-12 (via http://www.ncbi.nlm.nih.gov/pubmed/27185624)
We recently isolated an influenza A(H1N1)pdm09 E119D/H275Y neuraminidase (NA) variant from an immunocompromised patient who received oseltamivir and zanamivir therapies. This variant demonstrated cross ... C Chen, etc.,al. Multiple gene mutations identified in patients infected with influenza A (H7N9) virus. Scientific Reports 6, Article number: 25614 (2016). Abstract
submitted by kickingbird at May, 13, 2016 from Scientific Reports 6, Article number: 25614 (2016) (via http://www.nature.com/articles/srep25614)
Influenza A (H7N9) virus induced high mortality since 2013. It is important to elucidate the potential genetic variations that contribute to virus infection susceptibilities. In order to identify genetic ... SASAKI Y, Yoshino N, Sato S, Muraki Y, et al. Analysis of the beta-propiolactone sensitivity and optimization of inactivation methods for human influenza H3N2 virus. J Virol Methods. 2016 Apr 30. pii: S0166-0934(16)3. Abstract
submitted by kickingbird at May, 8, 2016 from J Virol Methods. 2016 Apr 30. pii: S0166-0934(16)3 (via J Virol Methods. 2016 Apr 30. pii: S0166-0934(16)30134-3.)
Beta-propiolactone (BPL) is widely used as an inactivating reagent for influenza virus. However, the treatment of viruses with BPL occasionally results in a decrease in the hemagglutinin (HA) titer, which ... FUSARO A, Tassoni L, Milani A, Hughes J, et al. Unexpected Inter-farm Transmission Dynamics During a Highly Pathogenic Avian Influenza Epidemic. J Virol. 2016 May 4. pii: JVI.00538-16. Abstract
submitted by kickingbird at May, 8, 2016 from J Virol. 2016 May 4. pii: JVI.00538-16 (via http://www.ncbi.nlm.nih.gov/pubmed/27147741)
Next Generation Sequencing technology is now being increasingly applied to study the within and between host population dynamics of viruses. However, information on avian influenza virus evolution and ... WONG JY, Wu P, Lau EH, Tsang TK, et al. Real-time estimation of the hospitalization fatality risk of influenza A(H1N1)pdm09 in Hong Kong. Epidemiol Infect. 2016 Jun;144(8):1579-83.. Abstract
submitted by kickingbird at May, 8, 2016 from Epidemiol Infect. 2016 Jun;144(8):1579-83. (via http://www.ncbi.nlm.nih.gov/pubmed/27125572)
During the early stage of an epidemic, timely and reliable estimation of the severity of infections are important for predicting the impact that the influenza viruses will have in the population. We obtained ... LYOO KS, Na W, Yeom M, Jeong DG, et al. Virulence of a novel reassortant canine H3N2 influenza virus in ferret, dog and mouse models. Arch Virol. 2016 Apr 30.. Abstract
submitted by kickingbird at May, 8, 2016 from Arch Virol. 2016 Apr 30. (via http://www.ncbi.nlm.nih.gov/pubmed/27138550)
An outbreak of a canine influenza virus (CIV) H3N2 reassortant derived from pandemic (pdm) H1N1 and CIV H3N2 in companion animals has underscored the urgent need to monitor CIV infections for potential ... J Virol. 2016 Apr 27. pii: JVI.00410. Rearrangement of influenza virus spliced segments for the development of live attenuated vaccines.. J Virol. 2016 Apr 27. pii: JVI.00410-16. Abstract
submitted by kickingbird at May, 1, 2016 from J Virol. 2016 Apr 27. pii: JVI.00410-16 (via http://www.ncbi.nlm.nih.gov/pubmed/27122587)
Influenza viral infections represent a serious public health problem, causing a contagious respiratory disease, which is most effectively prevented through vaccination. Segments seven (M) and eight (NS) ... JIANG J, Li J, Fan W, Zheng W, et al. Robust Lys63-linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection. J Virol. 2016 Apr 27. pii: JVI.00549-16. Abstract
submitted by kickingbird at May, 1, 2016 from J Virol. 2016 Apr 27. pii: JVI.00549-16 (via http://www.ncbi.nlm.nih.gov/pubmed/27122586)
Influenza A and B virus infections both cause a host innate immunity response. Here, we report that the robust production of type I and III interferons (IFNs), IFN-stimulated genes, and pre-inflammatory ... SUN H, Pu J, Wei Y, Sun Y, et al. Highly pathogenic avian influenza H5N6 viruses exhibit enhanced affinity for human type sialic acid receptor and in-contact transmission in model ferrets. J Virol. 2016 Apr 27. pii: JVI.00127-16.. Abstract
submitted by kickingbird at May, 1, 2016 from J Virol. 2016 Apr 27. pii: JVI.00127-16. (via http://www.ncbi.nlm.nih.gov/pubmed/27122581)
Since May 2014, highly pathogenic avian influenza (HPAI) H5N6 virus has been reported to cause six severe human infections three of which were fatal. The biological properties of this subtype, in particular ... SONG MS, Baek YH, Pascua PN, Kwon HI, et al. Growth and Pathogenic Potential of Naturally Selected Reassortants after Coinfection with Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Viruses. J Virol. 2015;90:616-23. Abstract
submitted by kickingbird at May, 1, 2016 from J Virol. 2015;90:616-23 (via http://www.ncbi.nlm.nih.gov/pubmed/26491154)
Coinfection of ferrets with H5N1 and pH1N1 viruses resulted in two predominate genotypes in the lungs containing surface genes of highly pathogenic avian influenza H5N1 virus in the backbone of pandemic ... BERTRAN K, Swayne DE, Pantin-Jackwood MJ, Kapczyns. Lack of chicken adaptation of newly emergent Eurasian H5N8 and reassortant H5N2 high pathogenicity avian influenza viruses in the U.S. is consistent with restricted poultry outbreaks in the Pacific fl. Virology. 2016;494:190-197. Abstract
submitted by kickingbird at May, 1, 2016 from Virology. 2016;494:190-197 (via http://www.ncbi.nlm.nih.gov/pubmed/27110710)
In 2014-2015, the U.S. experienced an unprecedented outbreak of Eurasian clade 2.3.4.4 H5 highly pathogenic avian influenza (HPAI) virus, initially affecting mainly wild birds and few backyard and commercial ... LIU WC, Lin YL, Spearman M, Cheng PY, et al. Influenza Hemagglutinin Glycoproteins with Different N-glycan Patterns Activate Dendritic Cells in Vitro. J Virol. 2016 Apr 20. pii: JVI.00452-16.. Abstract
submitted by kickingbird at Apr, 28, 2016 from J Virol. 2016 Apr 20. pii: JVI.00452-16. (via http://www.ncbi.nlm.nih.gov/pubmed/27099319)
Influenza HA N-glycans serve important regulatory roles in the control of virus virulence, antigenicity, receptor-binding specificity, and viral immune escape. Considered essential for controlling innate ... FUDO S, Yamamoto N, Nukaga M, Odagiri T, et al. Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit. Biochemistry. 2016 Apr 26. Abstract
submitted by kickingbird at Apr, 28, 2016 from Biochemistry. 2016 Apr 26 (via http://www.ncbi.nlm.nih.gov/pubmed/27088785)
Influenza viruses are global threat to humans, and the development of new antiviral agents are still demanded to prepare for pandemics and to overcome the emerging resistance to the current drugs. Influenza ... WU H, Lu R, Peng X, Peng X, et al. Isolation and genetic characterization of novel reassortant H6N6 subtype avian influenza viruses isolated from chickens in eastern China. Arch Virol. 2016 Apr 21.. Abstract
submitted by kickingbird at Apr, 28, 2016 from Arch Virol. 2016 Apr 21. (via http://www.ncbi.nlm.nih.gov/pubmed/27101069)
H6 subtype avian influenza viruses (AIVs) possess the ability to cross the species barrier to infect mammals and pose a threat to human health. From June 2014 to July 2015, 12 H6N6 AIVs were isolated from ... M.C.W.Chan, etc.,al. Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo. PNAS 2016 ; published ahead of print March 14, 201. Abstract
submitted by kickingbird at Mar, 29, 2016 from PNAS 2016 ; published ahead of print March 14, 201 (via http://www.pnas.org/content/early/2016/03/09/1601911113)
Influenza can cause acute lung injury. Because immune responses often play a role, antivirals may not ensure a successful outcome. To identify pathogenic mechanisms and potential adjunctive therapeutic ... SONG MS, Kumar G, Shadrick WR, Zhou W, et al. Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Proc Natl Acad Sci U S A. 2016 Mar 14. pii: 201519. Abstract
submitted by kickingbird at Mar, 21, 2016 from Proc Natl Acad Sci U S A. 2016 Mar 14. pii: 201519 (via http://www.ncbi.nlm.nih.gov/pubmed/26976575)
The influenza endonuclease is an essential subdomain of the viral RNA polymerase. It processes host pre-mRNAs to serve as primers for viral mRNA and is an attractive target for antiinfluenza drug discovery. ... Peiris JS, Cowling BJ, Wu JT, Feng L, Guan Y, Yu H. Interventions to reduce zoonotic and pandemic risks from avian influenza in Asia. Lancet Infect Dis. 2016 Feb;16(2):252-8. Abstract
submitted by kickingbird at Mar, 17, 2016 from Lancet Infect Dis. 2016 Feb;16(2):252-8 (via http://www.thelancet.com/journals/laninf/article/PIIS1473-30)
Novel influenza viruses continue to emerge, posing zoonotic and potentially pandemic threats, such as with avian influenza A H7N9. Although closure of live poultry markets (LPMs) in mainland China stopped ... 7775 items, 20/Page, Page[256/389][|<<] [|<] [251] [252] [253] [254] [255] [256] [257] [258] [259] [260] [>|] [>>|] |
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