LI W, Chen H, Sutton T, Obadan A, et al. Interactions between the Influenza A Virus RNA Polymerase Components and Retinoic Acid-Inducible Gene I. J Virol. 2014 Jun 18. pii: JVI.01383-14. Abstract
submitted by kickingbird at Jun, 24, 2014 from J Virol. 2014 Jun 18. pii: JVI.01383-14 (via http://www.ncbi.nlm.nih.gov/pubmed/24942585)
The influenza A virus genome possesses eight negative-strand RNA segments in the form of viral ribonucleoprotein particles (vRNPs) in association with the three viral RNA polymerase subunits (PB2, PB1, ... CHEN H, Angel M, Li W, Finch C, et al. All-in-one bacmids: An efficient reverse genetics strategy for influenza A virus vaccines. J Virol. 2014 Jun 18. pii: JVI.01468-14. Abstract
submitted by kickingbird at Jun, 24, 2014 from J Virol. 2014 Jun 18. pii: JVI.01468-14 (via http://www.ncbi.nlm.nih.gov/pubmed/24942589)
Vaccination is the first line of defense against influenza infections, yet influenza vaccine production methods are slow, antiquated, and expensive to effectively reduce the virus' burden during epidemic ... PYO CW, Shin N, Jung KI, Choi JH, et al. Alteration of copper-zinc superoxide dismutase 1 expression by influenza A virus is correlated with virus replication.. Biochem Biophys Res Commun. 2014 Jun 16.. Abstract
submitted by kickingbird at Jun, 24, 2014 from Biochem Biophys Res Commun. 2014 Jun 16. (via http://www.ncbi.nlm.nih.gov/pubmed/24946209)
Viruses have evolved mechanisms designated to potentiate virus replication by modulating the physiological condition of host cells. The generation of reactive oxygen species (ROS) during infection with ... LALIME EN, Pekosz A. The R35 residue of the influenza A virus NS1 protein has minimal effects on nuclear localization but alters virus replication through disrupting protein dimerization. Virology. 2014 Jun;458-459:33-42.. Abstract
submitted by kickingbird at Jun, 22, 2014 from Virology. 2014 Jun;458-459:33-42. (via http://www.ncbi.nlm.nih.gov/pubmed/24928037)
The influenza A virus NS1 protein has a nuclear localization sequence (NLS) in the amino terminal region. This NLS overlaps sequences that are important for RNA binding as well as protein dimerization. ... MALLAJOSYULA VV, Citron M, Ferrara F, Lu X, et al. Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection. Proc Natl Acad Sci U S A. 2014 Jun 9. pii: 2014027. Abstract
submitted by kickingbird at Jun, 22, 2014 from Proc Natl Acad Sci U S A. 2014 Jun 9. pii: 2014027 (via http://www.ncbi.nlm.nih.gov/pubmed/24927560)
Influenza hemagglutinin (HA) is the primary target of the humoral response during infection/vaccination. Current influenza vaccines typically fail to elicit/boost broadly neutralizing antibodies (bnAbs), ... ZHONG L, Wang X, Li Q, Liu D, et al. Molecular mechanism of the airborne transmissibility of H9N2 avian influenza A viruses in chickens. J Virol. 2014 Jun 11. pii: JVI.00943-14. Abstract
submitted by kickingbird at Jun, 22, 2014 from J Virol. 2014 Jun 11. pii: JVI.00943-14 (via http://www.ncbi.nlm.nih.gov/pubmed/24920791)
H9N2 avian influenza virus has been prevalent in poultry in many parts of the world since the 1990s and occasionally crosses the host barrier, transmitting to mammals, including humans. In recent years, ... HAN Q, Chang C, Li L, Klenk C, et al. Sumoylation of influenza A virus nucleoprotein is essential for intracellular trafficking and virus growth. J Virol. 2014 Jun 11. pii: JVI.00509-14.. Abstract
submitted by kickingbird at Jun, 22, 2014 from J Virol. 2014 Jun 11. pii: JVI.00509-14. (via http://www.ncbi.nlm.nih.gov/pubmed/24920808)
Viruses take advantage of host post-translational modifications for their own benefit. It was recently reported that influenza A virus proteins interact extensively with the host sumoylation system. Thereby, ... BELSER JA, Gustin KM, Katz JM, Maines TR, et al. Influenza virus infectivity and virulence following ocular-only aerosol inoculation of ferrets. J Virol. 2014 Jun 11. pii: JVI.01067-14.. Abstract
submitted by kickingbird at Jun, 22, 2014 from J Virol. 2014 Jun 11. pii: JVI.01067-14. (via http://www.ncbi.nlm.nih.gov/pubmed/24920819)
The study of respiratory pathogens has traditionally been performed by examining virus exposure to and infection of respiratory tract tissues. However, these studies typically overlook the role of ocular ... HASHEM AM, Gravel C, Chen Z, Yi Y, et al. CD40 Ligand Preferentially Modulates Immune Response and Enhances Protection against Influenza Virus. J Immunol. 2014 Jun 13. pii: 1300093.. Abstract
submitted by kickingbird at Jun, 22, 2014 from J Immunol. 2014 Jun 13. pii: 1300093. (via http://www.ncbi.nlm.nih.gov/pubmed/24928989)
CD40L, a key regulator of the immune system, was studied as both a targeting ligand and a molecular adjuvant in nucleoprotein (NP)-based host defense against influenza in mouse models with different genetic ... ZHANG P, Gu H, Bian C, Liu N, et al. Characterization of recombinant influenza A virus as a vector expressing respiratory syncytial virus fusion protein epitopes. J Gen Virol. 2014 Jun 9. pii: vir.0.064105-0. doi:. Abstract
submitted by kickingbird at Jun, 22, 2014 from J Gen Virol. 2014 Jun 9. pii: vir.0.064105-0. doi: (via http://www.ncbi.nlm.nih.gov/pubmed/24914066)
Respiratory syncytial virus (RSV) is the most common cause of respiratory infection in infants and the elderly, and no vaccine against this virus has yet been licensed. In this report, a recombinant PR8 ... Duan Y, Gu H, Chen R, Zhao Z, Zhang L, et al. Response of Mice and Ferrets to a Monovalent Influenza A (H7N9) Split Vaccine. PLoS ONE 9(6): e99322. doi:10.1371/journal.pone.0099322. Abstract
submitted by kickingbird at Jun, 20, 2014 from PLoS ONE 9(6): e99322. doi:10.1371/journal.pone.0099322 (via http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjourna)
In early spring 2013, the emergence of the influenza A (H7N9) virus in humans in Eastern China raised concerns of a new influenza pandemic. Development of a safe and effective H7N9 influenza vaccine is ... KASLOFF SB, Pizzuto MS, Silic-Benussi M, Pavone S,. Oncolytic activity of Avian influenza virus in human pancreatic ductal adenocarcinoma cell lines. J Virol. 2014 Jun 4. pii: JVI.00929-14. Abstract
submitted by kickingbird at Jun, 17, 2014 from J Virol. 2014 Jun 4. pii: JVI.00929-14 (via http://www.ncbi.nlm.nih.gov/pubmed/24899201)
Abstract
Pancreatic ductal adenocarcinoma (PDA) is the most lethal form of human cancer, with dismal survival rates due to late-stage diagnoses and lack of efficacious therapies. Building on the observation ... CZUDAI-MATWICH V, Otte A, Matrosovich M, Gabriel G. PB2 Mutations D701N and S714R Promote Adaptation of an Influenza H5N1 Virus to a Mammalian Host. J Virol. 2014 Jun 4. pii: JVI.00422. Abstract
submitted by kickingbird at Jun, 17, 2014 from J Virol. 2014 Jun 4. pii: JVI.00422 (via http://www.ncbi.nlm.nih.gov/pubmed/24899203)
Mutation D701N in the PB2 protein is known to play a prominent role in the adaptation of avian influenza A viruses to mammalian hosts. In contrast, little is known about mutations S714I and S714R located ... YUM J, Park EH, Ku KB, Kim JA, et al. Low infectivity of a novel avian-origin H7N9 influenza virus in pigs. Arch Virol. 2014 Jun 7. Abstract
submitted by kickingbird at Jun, 17, 2014 from Arch Virol. 2014 Jun 7 (via http://www.ncbi.nlm.nih.gov/pubmed/24906526)
We studied the pathogenesis and transmissibility of a novel avian-origin H7N9 influenza virus in pigs. When pigs were infected with H7N9 influenza virus, they did not show any clear clinical signs (such ... Ruibin Liang, Hui Li, Jessica M. J. Swanson, Grego. Multiscale simulation reveals a multifaceted mechanism of proton permeation through the influenza A M2 proton channel. PNAS 2014 ; published ahead of print June 16, 2014. Abstract
submitted by kickingbird at Jun, 17, 2014 from PNAS 2014 ; published ahead of print June 16, 2014 (via http://www.pnas.org/content/early/2014/06/11/1401997111.abst)
The influenza A virus M2 channel (AM2) is crucial in the viral life cycle. Despite many previous experimental and computational studies, the mechanism of the activating process in which proton permeation ... B Liu,etc.,al. Risk Factors for Influenza A(H7N9) Disease - China, 2013. Clin Infect Dis. (2014) doi: 10.1093/cid/ciu423. Abstract
submitted by kickingbird at Jun, 17, 2014 from Clin Infect Dis. (2014) doi: 10.1093/cid/ciu423 (via http://cid.oxfordjournals.org/content/early/2014/06/13/cid.c)
Background.?The majority of humans cases of novel avian influenza A(H7N9), which emerged in China in spring 2013, report exposure to poultry. However, specific host and exposure risk factors for disease ... BARRETT S, McKimm-Breschkin JL. Solid phase assay for comparing reactivation rates of neuraminidases of influenza wild type and resistant mutants after inhibitor removal. Antiviral Res. 2014 May 20. pii: S0166-3542(14)001. Abstract
submitted by kickingbird at Jun, 16, 2014 from Antiviral Res. 2014 May 20. pii: S0166-3542(14)001 (via http://www.ncbi.nlm.nih.gov/pubmed/24854981)
The influenza virus neuraminidase inhibitors are normally slow binding inhibitors, but many mutations leading to resistance, also result in the loss of the slow binding phenotype. Mutations can also affect ... SIMULUNDU E, Nao N, Yabe J, Muto NA, et al. The zoonotic potential of avian influenza viruses isolated from wild waterfowl in Zambia. Arch Virol. 2014. Abstract
submitted by kickingbird at Jun, 16, 2014 from Arch Virol. 2014 (via http://www.ncbi.nlm.nih.gov/pubmed/24862188)
Whilst remarkable progress in elucidating the mechanisms governing interspecies transmission and pathogenicity of highly pathogenic avian influenza viruses (AIVs) has been made, similar studies focusing ... PAN Y, Sasaki T, Kubota-Koketsu R, Inoue Y, et al. Human monoclonal antibodies derived from a patient infected with 2009 pandemic influenza A virus broadly cross-neutralize group 1 influenza viruses. Biochem Biophys Res Commun. 2014 May 22. pii: S000. Abstract
submitted by kickingbird at Jun, 16, 2014 from Biochem Biophys Res Commun. 2014 May 22. pii: S000 (via http://www.ncbi.nlm.nih.gov/pubmed/24858683)
Influenza viruses are a continuous threat to human public health because of their ability to evolve rapidly through genetic drift and reassortment. Three human monoclonal antibodies (HuMAbs) were generated ... SASAKI Y, Kakisaka M, Chutiwitoonchai N, Tajima S,. Identification of a novel multiple kinase inhibitor with potent antiviral activity against influenza virus by reducing viral polymerase activity. Biochem Biophys Res Commun. 2014 May 22. pii: S000. Abstract
submitted by kickingbird at Jun, 16, 2014 from Biochem Biophys Res Commun. 2014 May 22. pii: S000 (via http://www.ncbi.nlm.nih.gov/pubmed/24858693)
Neuraminidase inhibitors are the only currently available influenza treatment, although resistant viruses to these drugs have already been reported. Thus, new antiviral drugs with novel mechanisms of action ... 7516 items, 20/Page, Page[256/376][|<<] [|<] [251] [252] [253] [254] [255] [256] [257] [258] [259] [260] [>|] [>>|] |
Related Pages:
Browse by Category
Learn about the flu news, articles, events and more
Subscribe to the weekly F.I.C newsletter!
|
- 
