Budd AP, et al. Update: Influenza Activity - United States, October 1, 2017-February 3, 2018. MMWR Morb Mortal Wkly Rep. 2018. Abstract submitted by kickingbird at Feb, 19, 2018 from MMWR Morb Mortal Wkly Rep. 2018 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29447145/) Influenza activity in the United States began to increase in early November 2017 and rose sharply from December through February 3, 2018; elevated influenza activity is expected to continue for several ... Xiang D, Shen X, Pu Z, Irwin DM, et al. Convergent Evolution of Human-Isolated H7N9 Avian Influenza A Viruses. J Infect Dis 2018 Feb 9. Abstract submitted by kickingbird at Feb, 19, 2018 from J Infect Dis 2018 Feb 9 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29438519/) Background: Avian influenza A virus (AIV) H7N9 has caused five epidemic waves of human infections in China since 2013. AIVs may face strong selection to adapt to novel conditions when establishing themselves ... Anderson AM, Baranowska-Hustad M, Braathen R, Grod. Simultaneous Targeting of Multiple Hemagglutinins to APCs for Induction of Broad Immunity against Influenza. J Immunol 2018 Feb 2. Abstract submitted by kickingbird at Feb, 19, 2018 from J Immunol 2018 Feb 2 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29427414/) There is a need for vaccines that can confer broad immunity against highly diverse pathogens, such as influenza. The efficacy of conventional influenza vaccines is dependent on accurate matching of vaccines ... Coates BM, Staricha KL, Koch CM, Cheng Y, et al. Inflammatory Monocytes Drive Influenza A Virus-Mediated Lung Injury in Juvenile Mice. Immunol 2018 Feb 14. Abstract submitted by kickingbird at Feb, 19, 2018 from Immunol 2018 Feb 14 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29445006/) Healthy children are more likely to die of influenza A virus (IAV) infection than healthy adults. However, little is known about the mechanisms underlying the impact of young age on the development of ... Wu DBC, Chaiyakunapruk N, Pratoomsoot C, Lee KKC,. Cost-utility analysis of antiviral use under pandemic influenza using a novel approach - linking pharmacology, epidemiology and heath economics. Epidemiol Infect 2018 Feb 15:1-12. Abstract submitted by kickingbird at Feb, 19, 2018 from Epidemiol Infect 2018 Feb 15:1-12 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29446343/) Simulation models are used widely in pharmacology, epidemiology and health economics (HEs). However, there have been no attempts to incorporate models from these disciplines into a single integrated model. ... Cowling BJ. et al. Use of influenza antivirals in patients hospitalized in Hong Kong, 2000~2015. PLoS One. 2018 Jan 19;13(1):e0190306. Abstract submitted by kickingbird at Feb, 19, 2018 from PLoS One. 2018 Jan 19;13(1):e0190306 (via http://journals.plos.org/plosone/article?id=10.1371/journal.) ObjectivesWe aimed to describe patterns in the usage of antivirals to treat influenza virus infection in hospitals in Hong Kong from 2000 through 2015. MethodsWe analyzed centralized electronic health ... Geoghegan JL, Saavedra AF, Duchêne S, Sullivan S,. Continental synchronicity of human influenza virus epidemics despite climatic variation. Geoghegan JL. et al.. Abstract submitted by kickingbird at Feb, 19, 2018 from Geoghegan JL. et al. (via http://journals.plos.org/plospathogens/article?id=10.1371/jo) The factors that determine the pattern and rate of spread of influenza virus at a continental-scale are uncertain. Although recent work suggests that influenza epidemics in the United States exhibit a ... Virlogeux V. et al. Evaluation of animal-to-human and human-to-human transmission of influenza A (H7N9) virus in China, 2013~15. Scientific Reportsvolume 8, Article number: 552. Abstract submitted by kickingbird at Feb, 19, 2018 from Scientific Reportsvolume 8, Article number: 552 (via https://www.nature.com/articles/s41598-017-17335-9) A novel avian-origin influenza A(H7N9) virus emerged in China in March 2013 and by 27 September 2017 a total of 1533 laboratory-confirmed cases have been reported. Occurrences of animal-to-human and human-to-human ... White KM, Ayllon J, Mena I, Potenski A, et al. Influenza B virus reverse genetic backbones with improved growth properties in the EB66 cell line as basis for vaccine seed virus generation. Vaccine 2018;36:1146-1153. Abstract submitted by kickingbird at Feb, 11, 2018 from Vaccine 2018;36:1146-1153 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29395518/) Vaccination remains the best available prophylaxis to prevent influenza virus infections, yet current inadequacies in influenza virus vaccine manufacturing often lead to vaccine shortages at times when ... Westcott MM, Clemens EA, Holbrook BC, King SB, et. The choice of linker for conjugating R848 to inactivated influenza virus determines the stimulatory capacity for innate immune cells. Vaccine 2018;36:1174-1182.. Abstract submitted by kickingbird at Feb, 11, 2018 from Vaccine 2018;36:1174-1182. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29398273/) Inactivated influenza vaccines are not approved for use in infants less than 6?months of age due to poor immunogenicity in that population. While the live attenuated influenza vaccine has the potential ... Teng Y, Bi D, Guo X, Hu D, et al. Contact reductions from live poultry market closures limit the epidemic of human infections with H7N9 influenza. J Infect 2018 Jan 31. Abstract submitted by kickingbird at Feb, 11, 2018 from J Infect 2018 Jan 31 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29406153/) An early steep increase in the number of humans infected with avian influenza A(H7N9) virus was observed in China, raising great public concern domestically and internationally. Little is known about the ... Tsunekuni R, Yaguchi Y, Kashima Y, Yamashita K, et. Spatial transmission of H5N6 highly pathogenic avian influenza viruses among wild birds in Ibaraki Prefecture, Japan, 2016-2017. Arch Virol 2018 Feb 1. Abstract submitted by kickingbird at Feb, 11, 2018 from Arch Virol 2018 Feb 1 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29392495/) From 29 November 2016 to 24 January 2017, sixty-three cases of H5N6 highly pathogenic avian influenza virus (HPAIV) infections were detected in wild birds in Ibaraki Prefecture, Japan. Here, we analyzed ... Hashem AM, Azhar EI, Shalhoub S, Abujamel TS, et a. Genetic characterization and diversity of circulating influenza A/H1N1pdm09 viruses isolated in Jeddah, Saudi Arabia between 2014 and 2015. Arch Virol 2018 Feb 2. Abstract submitted by kickingbird at Feb, 11, 2018 from Arch Virol 2018 Feb 2 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29396684/) The emerged influenza A/H1N1pdm09 viruses have replaced the previously circulating seasonal H1N1 viruses. The close antigenic properties of these viruses to the 1918 H1N1 pandemic viruses and their post-pandemic ... Skowronski Danuta M, Chambers Catharine,etc.,al. Early season co-circulation of influenza A(H3N2) and B(Yamagata): interim estimates of 2017/18 vaccine effectiveness, Canada, January 2018. Euro Surveill. 2018;23(5):pii=18-00035. Abstract submitted by kickingbird at Feb, 8, 2018 from Euro Surveill. 2018;23(5):pii=18-00035 (via http://www.eurosurveillance.org/content/10.2807/1560-7917.ES) The 2017/18 influenza season in Canada has been characterised by co-circulation of influenza A(H3N2) and B(Yamagata) viruses, the latter unusual so early in the season [1]. Most European countries are ... Li H, Bradley KC, Long JS, Frise R, Ashcroft JW, H. Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice. PLoS Pathog 14(1): e1006821. Abstract submitted by kickingbird at Feb, 1, 2018 from PLoS Pathog 14(1): e1006821 (via http://journals.plos.org/plospathogens/article?id=10.1371/jo) The highly pathogenic avian influenza (HPAI) H5N1 influenza virus has been a public health concern for more than a decade because of its frequent zoonoses and the high case fatality rate associated with ... Anne Pohlmann,etc.,al. Swarm incursions of reassortants of highly pathogenic avian influenza virus strains H5N8 and H5N5, clade 2.3.4.4b, Germany, winter 2016/17. Scientific Reportsvolume 8, Article number: 15 (20. Abstract submitted by kickingbird at Feb, 1, 2018 from Scientific Reportsvolume 8, Article number: 15 (20 (via https://www.nature.com/articles/s41598-017-16936-8) The outbreak of highly pathogenic avian influenza H5Nx viruses in winter 2016/2017 was the most severe HPAI epizootic ever reported in Germany. The H5N8 and H5N5 viruses detected in birds in Germany in ... Shaoxia Lu,etc.,al. Genetics, pathogenicity and transmissibility of novel reassortant H5N6 highly pathogenic avian influenza viruses first isolated from migratory birds in western China. Emerging Microbes & Infections 7, Article number:. Abstract submitted by kickingbird at Feb, 1, 2018 from Emerging Microbes & Infections 7, Article number: (via https://www.nature.com/articles/s41426-017-0001-1) Novel H5N6 viruses were first documented in Laos in 2013 and subsequently reported in Vietnam and China1, but these viruses did not initially attract a great deal of attention. Instead, there was a greater ... Marjolein J. Poen,etc.,al. Local amplification of highly pathogenic avian influenza H5N8 viruses in wild birds in the Netherlands, 2016 to 2017. Euro Surveill. 2018;23(4):pii=17-00449.. Abstract submitted by kickingbird at Feb, 1, 2018 from Euro Surveill. 2018;23(4):pii=17-00449. (via http://www.eurosurveillance.org/content/10.2807/1560-7917.ES) Highly pathogenic avian influenza (HPAI) viruses of the H5 subtype, originating from the A/Goose/Guangdong/1/1996 (GsGd) lineage, have been circulating continuously in poultry in south-east Asia since ... Beerens N, Koch G, Heutink R, Harders F, Vries DPE. Novel Highly Pathogenic Avian Influenza A(H5N6) Virus in the Netherlands, December 2017. Emerg Infect Dis. 2018 Apr. Abstract submitted by kickingbird at Feb, 1, 2018 from Emerg Infect Dis. 2018 Apr (via https://wwwnc.cdc.gov/eid/article/24/4/17-2124_article) A novel highly pathogenic avian influenza A(H5N6) virus affecting wild birds and commercial poultry was detected in the Netherlands in December 2017. Phylogenetic analysis demonstrated that the virus is ... Kosik I, Ince WL, Gentles LE, Oler AJ, Kosikova M,. Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs. PLoS Pathog 14(1): e1006796.. Abstract submitted by kickingbird at Feb, 1, 2018 from PLoS Pathog 14(1): e1006796. (via http://journals.plos.org/plospathogens/article?id=10.1371/jo) Rapid antigenic evolution enables the persistence of seasonal influenza A and B viruses in human populations despite widespread herd immunity. 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