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2019-3-21 8:16:37
Article

Siegers JY, et al. Viral Factors Important for Efficient Replication of Influenza A Viruses in Cells of the Central Nervous System. J Virol. 2019 Mar 13..  Abstract  
submitted by kickingbird at 5 days ago from J Virol. 2019 Mar 13. (via https://jvi.asm.org/content/early/2019/03/07/JVI.02273-18)
Central nervous system (CNS) disease is one of the most common extra-respiratory tract complication of influenza A virus infections. Remarkably, zoonotic H5N1 virus infections are more frequently associated ...

Alnaji FG, et al. Sequencing framework for the sensitive detection and precise mapping of defective interfering particle-associated deletions across influenza A and B viruses. J Virol. 2019 Mar 13..  Abstract  
submitted by kickingbird at 5 days ago from J Virol. 2019 Mar 13. (via https://jvi.asm.org/content/early/2019/03/07/JVI.00354-19)
The mechanisms and consequences of defective interfering particle (DIP) formation during influenza virus infection remain poorly understood. The development of next generation sequencing (NGS) technologies ...

Nogales A, et al. A novel fluorescent and bioluminescent Bi-Reporter influenza A virus (BIRFLU) to evaluate viral infections. J Virol. 2019 Mar 13.  Abstract  
submitted by kickingbird at 5 days ago from J Virol. 2019 Mar 13 (via https://jvi.asm.org/content/early/2019/03/07/JVI.00032-19)
Studying influenza A virus (IAV) requires the use of secondary approaches to detect the presence of virus in infected cells. To overcome this problem, we and others have generated recombinant IAV expressing ...

Lai JCC, et al. Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding. Emerg Microbes Infect. 2019;8(1):327-338.  Abstract  
submitted by kickingbird at 5 days ago from Emerg Microbes Infect. 2019;8(1):327-338 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Influenza virus haemagglutinin (HA) and neuraminidase (NA) are involved in the recognition and modulation of sialic acids on the cell surface as the virus receptor. Although the balance between two proteins ...

Welkers MRA, et al. Genetic diversity and host adaptation of avian H5N1 influenza viruses during human infection. Emerg Microbes Infect. 2019;8(1):262-271..  Abstract  
submitted by kickingbird at 5 days ago from Emerg Microbes Infect. 2019;8(1):262-271. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
The continuing pandemic threat posed by avian influenza A/H5N1 viruses calls for improved insights into their evolution during human infection. We performed whole genome deep sequencing of respiratory ...

Monamele CG, et al. Evidence of exposure and human seroconversion during an outbreak of avian influenza A(H5N1) among poultry in Cameroon. Emerg Microbes Infect. 2019;8(1):186-196.  Abstract  
submitted by kickingbird at 5 days ago from Emerg Microbes Infect. 2019;8(1):186-196 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1)
From May 2016 to March 2017, 22 poultry outbreaks of avian influenza A(H5N1) were reported in Cameroon, mainly in poultry farms and live bird markets. No human cases were reported. In this study, we sought ...

Pan M, Yang HP, Jian J, et al. Association of meteorological factors with seasonal activity of influenza A subtypes and B lineages in subtropical western China. Epidemiol Infect. 2019 Jan;147:e72.  Abstract  
submitted by kickingbird at 5 days ago from Epidemiol Infect. 2019 Jan;147:e72 (via https://www.cambridge.org/core/journals/epidemiology-and-inf)
The seasonality of individual influenza subtypes/lineages and the association of influenza epidemics with meteorological factors in the tropics/subtropics have not been well understood. The impact of the ...

Amanat F, Meade P, Strohmeier S, Krammer F. Cross-reactive antibodies binding to H4 hemagglutinin protect against a lethal H4N6 influenza virus challenge in the mouse model. Emerg Microbes Infect. 2019;8(1):155-168.  Abstract  
submitted by kickingbird at 5 days ago from Emerg Microbes Infect. 2019;8(1):155-168 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1)
Influenza viruses of the H4 subtype are widespread in wild birds, circulate in domestic poultry, readily infect mammals, and tolerate the insertion of a polybasic cleavage site. In addition, serological ...

Bao L, et al. Diverse biological characteristics and varied virulence of H7N9 from Wave 5. Emerg Microbes Infect. 2019;8(1):94-102..  Abstract  
submitted by kickingbird at 5 days ago from Emerg Microbes Infect. 2019;8(1):94-102. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1)
There was a substantial increase with infections of H7N9 avian influenza virus (AIV) in humans during Wave 5 (2016-2017). To investigate whether H7N9 had become more infectious/transmissible and pathogenic ...

Schloer S, et al. The clinically licensed antifungal drug itraconazole inhibits influenza virus in vitro and in vivo. Emerg Microbes Infect. 2019;8(1):80-93..  Abstract  
submitted by kickingbird at 5 days ago from Emerg Microbes Infect. 2019;8(1):80-93. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1)
Influenza A virus (IAV) is a common pathogen of respiratory disease. The IAV-induced seasonal epidemics and the sporadic pandemics are associated with high morbidity and mortality. Therefore, effective ...

Yao Y, et al. Protection against homo and hetero-subtypic in?uenza A virus by optimized M2e DNA vaccine. Emerg Microbes Infect. 2019;8(1):45-54.  Abstract  
submitted by kickingbird at 5 days ago from Emerg Microbes Infect. 2019;8(1):45-54 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1)
Current influenza vaccines provide hemagglutinin strain-specific protection, but rarely provide cross-protection against divergent strains. It is, therefore, particularly important to develop a universal ...

Njifon HLM, et al. Genetic diversity of influenza A(H3N2) viruses in Northern Cameroon during the 2014-2016 influenza seasons. J Med Virol. 2019 Mar 13.  Abstract  
submitted by kickingbird at 6 days ago from J Med Virol. 2019 Mar 13 (via https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25456)
In Cameroon, genome characterization of influenza virus has been performed only in the Southern regions meanwhile genetic diversity of this virus varies with respect to locality. The Northern region characterized ...

Fritsch A, Schweiger B, Biere B. Influenza C virus in pre-school children with respiratory infections: retrospective analysis of data from the national influenza surveillance system in Germany, 2012 to 2014. Euro Surveill. 2019 Mar;24(10).  Abstract  
submitted by kickingbird at 6 days ago from Euro Surveill. 2019 Mar;24(10) (via https://www.eurosurveillance.org/content/10.2807/1560-7917.E)
IntroductionRecent data on influenza C virus indicate a possible higher clinical impact in specified patient populations than previously thought.AimWe aimed to investigate influenza C virus circulation ...

Wiman ?, et al. Novel influenza A(H1N2) seasonal reassortant identified in a patient sample, Sweden, January 2019. Euro Surveill. 2019 Feb;24(9).  Abstract  
submitted by kickingbird at 6 days ago from Euro Surveill. 2019 Feb;24(9) (via https://www.eurosurveillance.org/content/10.2807/1560-7917.E)
In January 2019, a human seasonal reassortant influenza A(H1N2) virus with a novel 7:1 genetic constellation was identified in a 68-year-old female patient with suspected pneumonia. The virus harboured ...

Quan L, Ji C, Ding X, Peng Y, Liu M, Sun J, et al. Cluster-transition determining sites underlying the antigenic evolution of seasonal influenza viruses. Mol Biol Evol. 2019 Mar 9.  Abstract  
submitted by kickingbird at 7 days ago from Mol Biol Evol. 2019 Mar 9 (via https://academic.oup.com/mbe/advance-article-abstract/doi/10)
Seasonal influenza viruses undergo frequent mutations on their surface hemagglutinin (HA) proteins to escape the host immune response. In these mutations, a few key amino acid sites are associated with ...

Karunakaran AC, et al. Survivability of Highly Pathogenic Avian Influenza Virus (H5N1) in naturally preened Duck Feathers at different temperatures. Transbound Emerg Dis. 2019 Mar 12..  Abstract  
submitted by kickingbird at 8 days ago from Transbound Emerg Dis. 2019 Mar 12. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13148)
Ducks are the "Trojan Horses" for Asian H5N1 avian influenza viruses (AIV) and attain carrier status without displaying overt infection. These birds help in the spread of the virus among the poultry and ...

Marques M, Ramos B, Soares AR, Ribeiro D. Cellular Proteostasis During Influenza A Virus Infection-Friend or Foe?. Cells. 2019 Mar 9;8(3).  Abstract  
submitted by kickingbird at 8 days ago from Cells. 2019 Mar 9;8(3) (via https://www.mdpi.com/2073-4409/8/3/228)
In order to efficiently replicate, viruses require precise interactions with host components and often hijack the host cellular machinery for their own benefit. Several mechanisms involved in protein synthesis ...

Ting-Hui-Lin, et al. Improving immunogenicity of influenza virus H7N9 recombinant hemagglutinin for vaccine development. Vaccine. 2019 Mar 22;37(13):1897-1903..  Abstract  
submitted by kickingbird at 8 days ago from Vaccine. 2019 Mar 22;37(13):1897-1903. (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Human infections of novel avian influenza A virus (H7N9) emerged in early 2013 and caused about 40% case-fatality through 2017. Therefore, development of influenza H7N9 vaccines is critical for pandemic ...

Cueno ME, et al. Structural significance of residues 158-160 in the H3N2 hemagglutnin globular head: A computational study with implications in viral evolution and infection. J Mol Graph Model. 2019 Feb 25;89:33-40..  Abstract  
submitted by kickingbird at 11 days ago from J Mol Graph Model. 2019 Feb 25;89:33-40. (via https://www.sciencedirect.com/science/article/pii/S109332631)
Influenza A H3N2 has been linked to annual outbreaks within the human population attributable to continuous structural changes. H3N2 HA contains well identified antigenic sites and receptor-binding sites ...

Bakri M, Samuh M, Azzeh M. Molecular epidemiology survey and characterization of human influenza A viruses circulating among Palestinians in East Jerusalem and the West Bank in 2015. PLoS One. 2019 Mar 8;14(3):e0213290.  Abstract  
submitted by kickingbird at 11 days ago from PLoS One. 2019 Mar 8;14(3):e0213290 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Frequent typing and molecular characterization of influenza A (IAV) strains are crucial for the identification of circulating subtypes and for the selection of the subtypes' lineages to be included in ...

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