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2021-2-27 2:23:27

Li X, Gu M, Zheng Q, Gao R, Liu X. Packaging signal of influenza A virus. Virol J. 2021 Feb 17;18(1):36.  Abstract  
submitted by kickingbird at 8 days ago from Virol J. 2021 Feb 17;18(1):36 (via https://pubmed.ncbi.nlm.nih.gov/33596956/)
Influenza A virus (IAV) contains a genome with eight single-stranded, negative-sense RNA segments that encode 17 proteins. During its assembly, all eight separate viral RNA (vRNA) segments are incorporated ...

Yang S, Ning S, Kou SC. Use Internet search data to accurately track state level influenza epidemics. Sci Rep. 2021 Feb 17;11(1):4023.  Abstract  
submitted by kickingbird at 8 days ago from Sci Rep. 2021 Feb 17;11(1):4023 (via https://pubmed.ncbi.nlm.nih.gov/33597556/)
For epidemics control and prevention, timely insights of potential hot spots are invaluable. Alternative to traditional epidemic surveillance, which often lags behind real time by weeks, big data from ...

Yang F, Xiao Y, Liu F, Yao H, Wu N, Wu H. Isolation and characterization of two novel reassortant H5N6 avian influenza viruses from waterfowl in eastern China. Arch Virol. 2021 Feb 17.  Abstract  
submitted by kickingbird at 8 days ago from Arch Virol. 2021 Feb 17 (via https://pubmed.ncbi.nlm.nih.gov/33598814/)
Waterfowl are considered to be the natural hosts of avian influenza virus. In 2017, two reassortant highly pathogenic H5N6 avian influenza viruses of clade, subclade II, were identified in wild ...

Kjaer LJ, Hjulsager CK, Larsen LE, Boklund AE, Hal. Landscape effects and spatial patterns of avian influenza virus in Danish wild birds, 2006-2020. Transbound Emerg Dis. 2021 Feb 18.  Abstract  
submitted by kickingbird at 8 days ago from Transbound Emerg Dis. 2021 Feb 18 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14040)
Avian influenza (AI) is a contagious disease of birds with zoonotic potential. AI virus (AIV) can infect most bird species, but clinical signs and mortality vary. Assessing the distribution and factors ...

Le Sage V, Jones JE, Kormuth KA, Fitzsimmons WJ, N. Pre-existing heterosubtypic immunity provides a barrier to airborne transmission of influenza viruses. PLoS Pathog. 2021 Feb 18;17(2):e1009273.  Abstract  
submitted by kickingbird at 8 days ago from PLoS Pathog. 2021 Feb 18;17(2):e1009273 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Human-to-human transmission of influenza viruses is a serious public health threat, yet the precise role of immunity from previous infections on the susceptibility to airborne infection is still unknown. ...

Kaku N, Hashiguchi K, Akamatsu N, Wakigawa F, Mats. Evaluation of a novel rapid TRC assay for the detection of influenza using nasopharyngeal swabs and gargle samples. Eur J Clin Microbiol Infect Dis. 2021 Feb 16.  Abstract  
submitted by kickingbird at 9 days ago from Eur J Clin Microbiol Infect Dis. 2021 Feb 16 (via https://pubmed.ncbi.nlm.nih.gov/33594599/)
We evaluated a novel transcription-reverse transcription concerted reaction (TRC) assay that can detect influenza A and B within 15 min using nasopharyngeal swab and gargle samples obtained from patients ...

Li APY, Cohen CA, Leung NHL, Fang VJ, Gangappa S,. Immunogenicity of standard, high-dose, MF59-adjuvanted, and recombinant-HA seasonal influenza vaccination in older adults. NPJ Vaccines. 2021 Feb 16;6(1):25.  Abstract  
submitted by kickingbird at 9 days ago from NPJ Vaccines. 2021 Feb 16;6(1):25 (via https://pubmed.ncbi.nlm.nih.gov/33594050/)
The vaccine efficacy of standard-dose seasonal inactivated influenza vaccines (S-IIV) can be improved by the use of vaccines with higher antigen content or adjuvants. We conducted a randomized controlled ...

Roubidoux EK, Carre?o JM, McMahon M, Jiang K, van. Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model. mBio. 2021 Feb 16;12(1):e03617-20.  Abstract  
submitted by kickingbird at 9 days ago from mBio. 2021 Feb 16;12(1):e03617-20 (via https://mbio.asm.org/content/12/1/e03617-20)
Current seasonal influenza virus vaccines target regions of the hemagglutinin (HA) head domain that undergo constant antigenic change, forcing the painstaking annual reformulation of vaccines. The development ...

Freyn AW, Han J, Guthmiller JJ, Bailey MJ, Neu K,. Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2018.  Abstract  
submitted by kickingbird at 9 days ago from Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2018 (via https://www.pnas.org/content/118/8/e2018102118)
In this study, we utilized a panel of human immunoglobulin (Ig) IgA monoclonal antibodies isolated from the plasmablasts of eight donors after 2014/2015 influenza virus vaccination (Fluarix) to study the ...

Wang B, Su Q, Luo J, Li M, Wu Q, Chang H, Du J, Hu. Differences in Highly Pathogenic H5N6 Avian Influenza Viral Pathogenicity and Inflammatory Response in Chickens and Ducks. Front Microbiol. 2021 Jan 29;12:593202.  Abstract  
submitted by kickingbird at 10 days ago from Front Microbiol. 2021 Jan 29;12:593202 (via https://www.frontiersin.org/articles/10.3389/fmicb.2021.5932)
Infection with H5N6 highly pathogenic avian influenza virus caused high mortality in chickens, while ducks often appear to be asymptomatic. But, some recent H5Nx subtype viruses could cause high mortality ...

Huang J, Wu S, Wu W, Liang Y, Zhuang H, Ye Z, Qu X. The Biological Characteristics of Novel H5N6 Highly Pathogenic Avian Influenza Virus and Its Pathogenesis in Ducks. Front Microbiol. 2021 Jan 26;12:628545.  Abstract  
submitted by kickingbird at 10 days ago from Front Microbiol. 2021 Jan 26;12:628545 (via https://www.frontiersin.org/articles/10.3389/fmicb.2021.6285)
Clade H5Nx highly pathogenic avian influenza viruses (HPAIVs) have caused outbreaks in poultry in the world. Some of these viruses acquired internal genes from other subtype avian influenza viruses ...

Gierak A, ?mietanka K, de Vos CJ. Quantitative risk assessment of the introduction of low pathogenic avian influenza H5 and H7 strains into Poland via legal import of live poultry. Prev Vet Med. 2021 Jan 28;189:105289.  Abstract  
submitted by kickingbird at 10 days ago from Prev Vet Med. 2021 Jan 28;189:105289 (via https://www.sciencedirect.com/science/article/abs/pii/S01675)
Low pathogenic avian influenza (LPAI) caused by H5 and H7 viruses is considered a threatening disease for poultry production due to the possibility of prolonged undetected virus circulation in a poultry ...

Hulme KD, Karawita AC, Pegg C, Bunte MJ, Bielefeld. A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants. Elife. 2021 Feb 16;10:e61803.  Abstract  
submitted by kickingbird at 10 days ago from Elife. 2021 Feb 16;10:e61803 (via https://pubmed.ncbi.nlm.nih.gov/33588989/)
Influenza virus has a high mutation rate, such that within one host different viral variants can emerge. Evidence suggests that influenza virus variants are more prevalent in pregnant and/or obese individuals ...

Lages NC, Debbeler LJ, Blumenschein M, Kollmann J,. Dynamic Risk Perceptions in Times of Avian and Seasonal Influenza Epidemics: A Repeated Cross-Sectional Design. Risk Anal. 2021 Feb 13.  Abstract  
submitted by kickingbird at 11 days ago from Risk Anal. 2021 Feb 13 (via https://onlinelibrary.wiley.com/doi/10.1111/risa.13706)
Infectious diseases pose a serious threat to humans. Therefore, it is crucial to understand how accurately people perceive these risks. However, accuracy can be operationalized differently depending on ...

Patel MC, Chesnokov A, Jones J, Mishin VP, De La C. Susceptibility of widely diverse influenza a viruses to PB2 polymerase inhibitor pimodivir. Antiviral Res. 2021 Feb 10:105035.  Abstract  
submitted by kickingbird at 11 days ago from Antiviral Res. 2021 Feb 10:105035 (via https://www.sciencedirect.com/science/article/pii/S016635422)
Pimodivir exerts an antiviral effect on the early stages of influenza A virus replication by inhibiting the cap-binding function of polymerase basic protein 2 (PB2). In this study, we used a combination ...

Sch?n J, Ran W, Gorka M, Schwemmle M, Beer M, Hoff. A modified live bat influenza A virus-based vaccine prototype provides full protection against HPAIV H5N1. NPJ Vaccines. 2020 May 15;5(1):40.  Abstract  
submitted by kickingbird at 13 days ago from NPJ Vaccines. 2020 May 15;5(1):40 (via https://www.nature.com/articles/s41541-020-0185-6)
Highly pathogenic avian influenza viruses (HPAIVs) of subtype H5 are a major threat for poultry holdings worldwide, here especially the zoonotic Asian H5N1 viruses. These HPAIVs have caused more than 500 ...

Pleguezuelos O, James E, Fernandez A, Lopes V, Ros. Efficacy of FLU-v, a broad-spectrum influenza vaccine, in a randomized phase IIb human influenza challenge study. NPJ Vaccines. 2020 Mar 13;5(1):22.  Abstract  
submitted by kickingbird at 13 days ago from NPJ Vaccines. 2020 Mar 13;5(1):22
FLU-v, developed by PepTcell (SEEK), is a peptide vaccine aiming to provide a broadly protective cellular immune response against influenza A and B. A randomized, double-blind, placebo-controlled, single-center, ...

de Jonge J, van Dijken H, de Heij F, Spijkers S, M. H7N9 influenza split vaccine with SWE oil-in-water adjuvant greatly enhances cross-reactive humoral immunity and protection against severe pneumonia in ferrets. NPJ Vaccines. 2020 May 11;5(1):38..  Abstract  
submitted by kickingbird at 13 days ago from NPJ Vaccines. 2020 May 11;5(1):38. (via https://www.nature.com/articles/s41541-020-0187-4)
Until universal influenza vaccines become available, pandemic preparedness should include developing classical vaccines against potential pandemic influenza subtypes. We here show that addition of SWE ...

Kim WH, Bae SH, Cho S. Spatiotemporal Dynamics of Highly Pathogenic Avian Influenza Subtype H5N8 in Poultry Farms, South Korea. Viruses. 2021 Feb 10;13(2):274.  Abstract  
submitted by kickingbird at 13 days ago from Viruses. 2021 Feb 10;13(2):274 (via https://www.mdpi.com/1999-4915/13/2/274)
Highly pathogenic avian influenza (HPAI), a zoonotic disease, is a major threat to humans and poultry health worldwide. In January 2014, HPAI virus subtype H5N8 first infected poultry farms in South Korea, ...

Tsuneki-Tokunaga A, Kanai K, Itagaki A, Tsuchie H,. Growth capability of epidemic influenza viruses in Japan since the 2009 H1N1 pandemic. Arch Virol. 2021 Feb 12.  Abstract  
submitted by kickingbird at 13 days ago from Arch Virol. 2021 Feb 12 (via https://link.springer.com/article/10.1007/s00705-021-04976-5)
AbstractThe correlation of viral growth capability (n = 156) with the viral load in nasopharyngeal swabs (n = 76) was assessed. Epidemic influenza A/H1N1, A/H3N2, and B viruses showed a wide range of growth ...

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