Kim KH, Jung YJ, Lee Y, et al. Cross protection by inactivated recombinant influenza viruses containing chimeric hemagglutinin conjugates with a conserved neuraminidase or M2 ectodomain epitope. Virology. 2020;550:51-60. Abstract
submitted by kickingbird at 14 days ago from Virology. 2020;550:51-60 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza virus neuraminidase (NA) contains a universally conserved epitope (NAe, NA222-230). However, no studies have reported vaccines targeting this NA conserved epitope and inducing antibodies recognizing ...
Hassan MM, El Zowalaty ME, Islam A, et al. Serological Evidence of Avian Influenza in Captive Wild Birds in a Zoo and Two Safari Parks in Bangladesh. Vet Sci. 2020;7(3):E122. Abstract
submitted by kickingbird at 14 days ago from Vet Sci. 2020;7(3):E122 (via https://www.mdpi.com/2306-7381/7/3/122)
Avian influenza (AI) is endemic and frequently causes seasonal outbreaks in winter in Bangladesh due to high pathogenic avian influenza (HPAI) H5N1 and low pathogenic avian influenza (LPAI) H9N2. Among ...
Shittu I, Meseko CA, Sulaiman LP, et al. Fatal multiple outbreaks of equine influenza H3N8 in Nigeria, 2019: The first introduction of Florida clade 1 to West Africa. Vet Microbiol. 2020;248:108820. Abstract
submitted by kickingbird at 14 days ago from Vet Microbiol. 2020;248:108820 (via https://www.sciencedirect.com/science/article/pii/S037811352)
In December 2018, suspected outbreaks of equine influenza (EI) were observed in donkeys in Sokoto State, in the extreme northwest of Nigeria bordering the Republic of the Niger. Equine influenza virus ...
Friel D, Co M, Ollinger T, et al. Non-neutralizing antibody responses following A(H1N1)pdm09 influenza vaccination with or without AS03 adjuvant system. Influenza Other Respir Viruses. 2020;10.1111/irv.1. Abstract
submitted by kickingbird at 14 days ago from Influenza Other Respir Viruses. 2020;10.1111/irv.1 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12780)
Background: Non-neutralizing antibodies inducing complement-dependent lysis (CDL) and antibody-dependent cell-mediated cytotoxicity (ADCC) activity may contribute to protection against influenza infection. ...
Xia Z, Yang L, Li N, et al. Seasonal influenza activity in young children before the COVID-19 outbreak in Wuhan, China. Transbound Emerg Dis. 2020;10.1111/tbed.13799. Abstract
submitted by kickingbird at Sep, 4, 2020 from Transbound Emerg Dis. 2020;10.1111/tbed.13799 (via https://onlinelibrary.wiley.com/doi/full/10.1111/tbed.13799)
The activity of influenza A at the end of 2019 was higher than previous two years in children younger than 6 years old in Wuhan, China. The 2019-2020 winter peak of seasonal influenza preceded the COVID-19 ...
Dawson AR, Wilson GM, Freiberger EC, Mondal A, Coo. Phosphorylation controls RNA binding and transcription by the influenza virus polymerase. PLoS Pathog. 2020;16(9):e1008841. Abstract
submitted by kickingbird at Sep, 4, 2020 from PLoS Pathog. 2020;16(9):e1008841 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
The influenza virus polymerase transcribes and replicates the viral genome. The proper timing and balance of polymerase activity is important for successful replication. Genome replication is controlled ...
Zhao S, Schuurman N, Tieke M, et al. Serological screening of influenza A virus antibodies in cats and dogs indicates frequent infection with different subtypes. J Clin Microbiol. 2020. Abstract
submitted by kickingbird at Sep, 4, 2020 from J Clin Microbiol. 2020 (via https://jcm.asm.org/content/early/2020/08/27/JCM.01689-20)
Influenza A viruses (IAVs) infect humans and a variety of other animal species. Infections with some subtypes of IAV were also reported in domestic cats and dogs. Besides animal health implications, close ...
Chia BS, Li B, Cui A, et al. Loss of the nuclear protein RTF2 enhances influenza replication. J Virol. 2020;JVI.00319-20.. Abstract
submitted by kickingbird at Sep, 4, 2020 from J Virol. 2020;JVI.00319-20. (via https://jvi.asm.org/content/early/2020/08/27/JVI.00319-20)
While hundreds of genes are induced by type I interferons, their roles in restricting the influenza life cycle remain mostly unknown. Using a loss-of-function CRISPR screen in cells pre-stimulated with ...
Haralampiev I, Prisner S, Nitzan M, et al. Selective flexible packaging pathways of the segmented genome of influenza A virus. Nat Commun. 2020;11(1):4355. Abstract
submitted by kickingbird at Sep, 1, 2020 from Nat Commun. 2020;11(1):4355 (via https://www.nature.com/articles/s41467-020-18108-1)
The genome of influenza A viruses (IAV) is encoded in eight distinct viral ribonucleoproteins (vRNPs) that consist of negative sense viral RNA (vRNA) covered by the IAV nucleoprotein. Previous studies ...
Song CL, Liao ZH, Shen Y, et al. Assessing the efficacy of a recombinant H9N2 avian influenza virus-inactivated vaccine. Poult Sci. 2020;99(9):4334-4342. Abstract
submitted by kickingbird at Sep, 1, 2020 from Poult Sci. 2020;99(9):4334-4342 (via https://www.sciencedirect.com/science/article/pii/S003257912)
The H9N2 avian influenza virus has been widely spread in poultry around the world. It is proved to the world that the avian influenza virus can directly infect human beings without any intermediate host ...
Mehaffey MR, Lee J, Jung J, et al. Mapping a Conformational Epitope of Hemagglutinin A Using Native Mass Spectrometry and Ultraviolet Photodissociation. Anal Chem. 2020;92(17):11869-11878. Abstract
submitted by kickingbird at Sep, 1, 2020 from Anal Chem. 2020;92(17):11869-11878 (via https://pubs.acs.org/doi/10.1021/acs.analchem.0c02237)
As the importance of effective vaccines and the role of protein therapeutics in the drug industry continue to expand, alternative strategies to characterize protein complexes are needed. Mass spectrometry ...
Li BD, He J, Li HY, et al. Analysis on genetic characteristics of H9N2 avian influenza virus isolated from human infection and external environment in Gansu province. Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41(8):1345. Abstract
submitted by kickingbird at Sep, 1, 2020 from Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41(8):1345 (via https://pubmed.ncbi.nlm.nih.gov/32867448/)
Objective: To analyze the genomic characteristics of human infection with H9N2 avian influenza virus in Gansu province. Methods: The etiological analysis was conducted for human infection with H9N2 avian ...
Wacquiez A, Coste F, Kut E, et al. Structure and Sequence Determinants Governing the Interactions of RNAs with Influenza A Virus Non-Structural Protein NS1. Viruses. 2020;12(9):E947. Abstract
submitted by kickingbird at Sep, 1, 2020 from Viruses. 2020;12(9):E947 (via https://www.mdpi.com/1999-4915/12/9/947)
The non-structural protein NS1 of influenza A viruses is an RNA-binding protein of which its activities in the infected cell contribute to the success of the viral cycle, notably through interferon antagonism. ...
Turner JS, Zhou JQ, Han J, et al. Human germinal centres engage memory and naive B cells after influenza vaccination. Nature. 2020;10.1038/s41586-020-2711-0. Abstract
submitted by kickingbird at Sep, 1, 2020 from Nature. 2020;10.1038/s41586-020-2711-0 (via https://www.nature.com/articles/s41586-020-2711-0)
Influenza viruses remain a major public health threat. Seasonal influenza vaccination in humans primarily stimulates pre-existing memory B cells, leading to a transient wave of circulating antibody-secreting ...
Percopo CM, Ma M, Mai E, et al. Alternaria alternata Accelerates Loss of Alveolar Macrophages and Promotes Lethal Influenza A Infection. Viruses. 2020;12(9):E946. Abstract
submitted by kickingbird at Sep, 1, 2020 from Viruses. 2020;12(9):E946 (via https://pubmed.ncbi.nlm.nih.gov/32867061/)
Chronic inhalation of fungi and fungal components has been linked to the development of respiratory disorders, although their role with respect to the pathogenesis of acute respiratory virus infection ...
Du W, Wolfert MA, Peeters B, et al. Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin. PLoS Pathog. 2020;16(8):e1008816. Abstract
submitted by kickingbird at Aug, 31, 2020 from PLoS Pathog. 2020;16(8):e1008816 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A viruses (IAVs) cause seasonal epidemics and occasional pandemics. Most pandemics occurred upon adaptation of avian IAVs to humans. This adaptation includes a hallmark receptor-binding specificity ...
Ilyushina NA, Lee N, Lugovtsev VY, Kan A, Bovin NV. Adaptation of influenza B virus by serial passage in human airway epithelial cells. Virology. 2020;549:68-76. Abstract
submitted by kickingbird at Aug, 31, 2020 from Virology. 2020;549:68-76 (via https://pubmed.ncbi.nlm.nih.gov/32853848/)
Influenza B viruses cause seasonal epidemics and are a considerable burden to public health. To understand their adaptation capability, we examined the genetic changes that occurred following 15 serial ...
?wi?toń E, Tarasiuk K, ?mietanka K. Low pathogenic avian influenza virus isolates with different levels of defective genome segments vary in pathogenicity and transmission efficiency. Vet Res. 2020;51(1):108. Abstract
submitted by kickingbird at Aug, 31, 2020 from Vet Res. 2020;51(1):108 (via https://pubmed.ncbi.nlm.nih.gov/32859269/)
Defective interfering particles (DIPs) of influenza virus are generated through incorporation of highly truncated forms of genome segments, mostly those coding polymerase complex proteins (PB2, PB1, PA). ...
Jerry C, Stallknecht D, Leyson C, et al. Recombinant hemagglutinin glycoproteins provide insight into binding to host cells by H5 influenza viruses in wild and domestic birds. irology. 2020;550:8-20. Abstract
submitted by kickingbird at Aug, 31, 2020 from irology. 2020;550:8-20 (via https://pubmed.ncbi.nlm.nih.gov/32861143/)
Clade 184.108.40.206, H5 subtype highly pathogenic avian influenza viruses (HPAIVs) have caused devastating effects across wild and domestic bird populations. We investigated differences in the intensity and ...
Seekings AH, Howard WA, Nu?éz A, et al. The Emergence of H7N7 Highly Pathogenic Avian Influenza Virus from Low Pathogenicity Avian Influenza Virus Using an in ovo Embryo Culture Model. Viruses. 2020;12(9):E920. Abstract
submitted by kickingbird at Aug, 26, 2020 from Viruses. 2020;12(9):E920 (via https://www.mdpi.com/1999-4915/12/9/920)
Outbreaks of highly pathogenic avian influenza virus (HPAIV) often result in the infection of millions of poultry, causing up to 100% mortality. HPAIV has been shown to emerge from low pathogenicity avian ...
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