Abhijeet A Bakre, et al. Molecular epidemiology and glycomics of swine influenza viruses circulating in commercial swine farms in the southeastern and midwest United States. Vet Microbiol . 2020 Oct 31;251:108914. Abstract
submitted by kickingbird at Nov, 16, 2020 from Vet Microbiol . 2020 Oct 31;251:108914 (via https://www.sciencedirect.com/science/article/pii/S037811352)
Tracking the genetic diversity and spread of swine influenza viruses (SIVs) in commercial swine farms is central for control and to reduce the potential emergence of SIV reassortants. We analyzed the diversity ...
Carre?o JM, McDonald JU, Hurst T, Rigsby P, Atkins. Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies. Vaccines (Basel). 2020 Nov 9;8(4):E666. Abstract
submitted by kickingbird at Nov, 16, 2020 from Vaccines (Basel). 2020 Nov 9;8(4):E666 (via https://www.mdpi.com/2076-393X/8/4/666)
The stalk domain of the hemagglutinin has been identified as a target for induction of protective antibody responses due to its high degree of conservation among numerous influenza subtypes and strains. ...
Tian X, Landreth S, Lu Y, Pandey K, Zhou Y. A Replication-Defective Influenza Virus Harboring H5 and H7 Hemagglutinins Provides Protection against H5N1 and H7N9 Infection in Mice. J Virol. 2020 Nov 11:JVI.02154-20. Abstract
submitted by kickingbird at Nov, 13, 2020 from J Virol. 2020 Nov 11:JVI.02154-20 (via https://jvi.asm.org/content/early/2020/11/06/JVI.02154-20)
The recent highly pathogenic avian influenza (HPAI) H5N1 and H7N9 viruses have caused hundreds of human infections with high mortality rates. Although H5N1 and H7N9 viruses have been mainly limited to ...
Bao D, Xue R, Zhang M, Lu C, Ma T, Ren C, Zhang T,. N-linked glycosylation plays an important role in budding of NA protein and virulence of influenza viruses. J Virol. 2020 Nov 11:JVI.02042-20. Abstract
submitted by kickingbird at Nov, 13, 2020 from J Virol. 2020 Nov 11:JVI.02042-20 (via https://jvi.asm.org/content/early/2020/11/06/JVI.02042-20)
Neuraminidase (NA) has multiple functions in the life cycle of influenza virus, especially in the late stage of virus replication. Both of Hemagglutinin (HA) and NA are highly glycosylated proteins. N-linked ...
Speake HA, Pereira G, Regan AK. Risk of adverse maternal and foetal outcomes associated with inactivated influenza vaccination in first trimester of pregnancy. Paediatr Perinat Epidemiol. 2020 Nov 5. Abstract
submitted by kickingbird at Nov, 9, 2020 from Paediatr Perinat Epidemiol. 2020 Nov 5 (via https://onlinelibrary.wiley.com/doi/10.1111/ppe.12715)
Background: In many countries, influenza vaccination is routinely recommended during any stage of pregnancy, yet uptake remains low, particularly in the first trimester. This is thought to be due to maternal ...
Toy R, Keenum MC, Pradhan P, Phang K, Chen P, Chuk. TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells in vitro and generate unique cellular immune responses in influenza vaccinatio. J Control Release. 2020 Nov 4:S0168-3659(20)30641-. Abstract
submitted by kickingbird at Nov, 9, 2020 from J Control Release. 2020 Nov 4:S0168-3659(20)30641- (via https://www.sciencedirect.com/science/article/abs/pii/S01683)
Although the existing flu vaccines elicit strong antigen-specific antibody responses, they fail to provide effective, long term protection - partly due to the absence of robust cellular memory immunity. ...
Zaraket H, Hurt AC, Clinch B, Barr I, Lee N. Burden of influenza B virus infection and considerations for clinical management. Antiviral Res. 2020 Nov 4:104970. Abstract
submitted by kickingbird at Nov, 9, 2020 from Antiviral Res. 2020 Nov 4:104970 (via https://www.sciencedirect.com/science/article/abs/pii/S01663)
Influenza B viruses cause significant morbidity and mortality, particularly in children, but the awareness of their impact is often less than influenza A viruses partly due to their lack of pandemic potential. ...
Vagima Y, Gur D, Erez N, Achdout H, Aftalion M, Le. Influenza virus infection augments susceptibility to respiratory Yersinia pestis exposure and impacts the efficacy of antiplague antibiotic treatments. Sci Rep. 2020 Nov 5;10(1):19116. Abstract
submitted by kickingbird at Nov, 8, 2020 from Sci Rep. 2020 Nov 5;10(1):19116 (via https://www.nature.com/articles/s41598-020-75840-w)
Various respiratory viral infections in general and seasonal influenza in particular may increase the susceptibility to bacterial infections. Plague caused by Yersinia pestis endangers large populations ...
Timofeeva TA, Rudneva IA, Sadykova GK, Lomakina NF. Variability of nonpathogenic influenza virus H5N3 under immune pressure. Acta Virol. 2020 Nov 5. Abstract
submitted by kickingbird at Nov, 7, 2020 from Acta Virol. 2020 Nov 5 (via https://pubmed.ncbi.nlm.nih.gov/33151742/)
Mutations arising in influenza viruses that have undergone immune pressure may promote a successful spread of mutants in nature. In order to evaluate the variability of nonpathogenic influenza virus A/duck/Moscow/4182-C/2010(H5N3) ...
Igboh LS, McMorrow M, Tempia S, Emukule GO, Talla. Influenza surveillance capacity improvements in Africa during 2011-2017. Influenza Other Respir Viruses. 2020 Nov 4. Abstract
submitted by kickingbird at Nov, 7, 2020 from Influenza Other Respir Viruses. 2020 Nov 4 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.12818)
Background: Influenza surveillance helps time prevention and control interventions especially where complex seasonal patterns exist. We assessed influenza surveillance sustainability in Africa where influenza ...
Kotomina T, Isakova-Sivak I, Kim KH, Park BR, Jung. Generation and Characterization of Universal Live-Attenuated Influenza Vaccine Candidates Containing Multiple M2e Epitopes. Vaccines (Basel). 2020 Nov 3;8(4):E648. Abstract
submitted by kickingbird at Nov, 7, 2020 from Vaccines (Basel). 2020 Nov 3;8(4):E648 (via https://www.mdpi.com/2076-393X/8/4/648)
Influenza viruses constantly evolve, reducing the overall protective effect of routine vaccination campaigns. Many different strategies are being explored to design universal influenza vaccines capable ...
Liu X, Zhang B, Wang Y, Haymour HS, Zhang F, Xu LC. A universal dual mechanism immunotherapy for the treatment of influenza virus infections. Nat Commun. 2020 Nov 5;11(1):5597. Abstract
submitted by kickingbird at Nov, 7, 2020 from Nat Commun. 2020 Nov 5;11(1):5597 (via https://www.nature.com/articles/s41467-020-19386-5)
Seasonal influenza epidemics lead to 3-5 million severe infections and 290,000-650,000 annual global deaths. With deaths from the 1918 influenza pandemic estimated at >50,000,000 and future pandemics anticipated, ...
Thompson AJ, Paulson JC. Adaptation of Influenza Viruses to Human Airway Receptors. Biol Chem. 2020 Nov 3:jbc.REV120.013309. Abstract
submitted by kickingbird at Nov, 5, 2020 from Biol Chem. 2020 Nov 3:jbc.REV120.013309 (via https://www.jbc.org/content/early/2020/11/03/jbc.REV120.0133)
Through annual epidemics and global pandemics, influenza A viruses (IAVs) remain a significant threat to human health as the leading cause of severe respiratory disease. Within the last century, four global ...
Cox A, Schmierer J, D´Angelo J, Smith A, Lev. A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity. Viruses. 2020 Oct 31;12(11):E1246. Abstract
submitted by kickingbird at Nov, 5, 2020 from Viruses. 2020 Oct 31;12(11):E1246 (via https://www.mdpi.com/1999-4915/12/11/1246)
Current influenza vaccines have modest efficacy. This is especially true for current live attenuated influenza vaccines (LAIV), which have been inferior to the inactivated versions in recent years. Therefore, ...
Liu B, Wang Y, Liu Y, Chen Y, Liu Y, Cong X, Ji Y,. Molecular evolution and characterization of hemagglutinin and neuraminidase of influenza A(H1N1)pdm09 viruses isolated in Beijing, China, during the 2017-2018 and 2018-2019 influenza seasons. Arch Virol. 2020 Nov 3. Abstract
submitted by kickingbird at Nov, 5, 2020 from Arch Virol. 2020 Nov 3 (via https://link.springer.com/article/10.1007/s00705-020-04869-z)
We investigated and analysed the molecular evolution of hemagglutinin (HA) and neuraminidase (NA) of influenza A(H1N1)pdm09 virus during the 2017-2018 and 2018-2019 influenza seasons in Beijing, China. ...
Shinde V, Cai R, Plested J, Cho I, Fiske J, Pham X. Induction of Cross-reactive Hemagglutination Inhibiting Antibody and Polyfunctional CD4+ T-cell Responses by a Recombinant Matrix-M-Adjuvanted Hemagglutinin Nanoparticle Influenza Vaccine. Clin Infect Dis. 2020 Nov 4:ciaa1673. Abstract
submitted by kickingbird at Nov, 5, 2020 from Clin Infect Dis. 2020 Nov 4:ciaa1673 (via https://academic.oup.com/cid/advance-article/doi/10.1093/cid)
Background: Recurrent reports of suboptimal influenza vaccine effectiveness have renewed calls to develop improved, broadly cross-protective influenza vaccines. Here, we evaluated the safety and immunogenicity ...
Escalera-Zamudio, M., Golden, M., Gutiérrez, B. et. Parallel evolution in the emergence of highly pathogenic avian influenza A viruses. Nat Commun 11, 5511 (2020). Abstract
submitted by kickingbird at Nov, 5, 2020 from Nat Commun 11, 5511 (2020) (via https://www.nature.com/articles/s41467-020-19364-x)
Parallel molecular evolution and adaptation are important phenomena commonly observed in viruses. Here, we exploit parallel molecular evolution to understand virulence evolution in avian influenza viruses ...
Alnaeem AA, Al-Shabeb A, Hemida MG. Evaluation of the immune status of birds and domestic and companion animals for the influenza A virus in Eastern Saudi Arabia. Vet World. 2020 Sep;13(9):1966-1969. Abstract
submitted by kickingbird at Nov, 3, 2020 from Vet World. 2020 Sep;13(9):1966-1969 (via http://www.veterinaryworld.org/Vol.13/September-2020/30.html)
Background and aim: Influenza type A virus infections are still one of the major concerns for the health of humans and various species of domestic and companion animals. Wild birds play an essential role ...
Perez-Vilar S, Hu M, Weintraub E, Arya D, Lufkin B. Guillain-Barré Syndrome After High-Dose Influenza Vaccine Administration in the United States, 2018-2019 Season. J Infect Dis. 2020 Nov 2:jiaa543. Abstract
submitted by kickingbird at Nov, 3, 2020 from J Infect Dis. 2020 Nov 2:jiaa543 (via https://academic.oup.com/jid/advance-article/doi/10.1093/inf)
Background: The Vaccine Safety Datalink (VSD) identified a statistical signal for an increased risk of Guillain-Barré syndrome (GBS) in days 1-42 after 2018-2019 high-dose influenza vaccine (IIV3-HD) administration. ...
Wang X, Lin L, Yu Y, Yan Y, Ojha NK, Zhou J. The N-terminal residual arginine 19 of influenza A virus NS1 protein is required for its nuclear localization and RNA binding. Vet Microbiol. 2020 Oct 14;251:108895. Abstract
submitted by kickingbird at Nov, 2, 2020 from Vet Microbiol. 2020 Oct 14;251:108895 (via https://www.sciencedirect.com/science/article/pii/S037811352)
RNA binding ability and cellular distribution are important for nonstructural protein 1 (NS1) of influenza A virus to act as a viral regulatory factor to control virus life cycle. In this study, we identified ...
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