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2026-2-12 1:46:28
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Filipe JAN, Wong CKH, van Leeuwen E, Goodfellow L,. A systematised review of seasonal influenza case-fatality risk. Vaccine. 2025 Nov 29;60 Suppl 2:128011.  Abstract  
submitted by kickingbird at Dec, 3, 2025 from Vaccine. 2025 Nov 29;60 Suppl 2:128011 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Case-fatality risk (CFR) is an important indicator of disease severity for influenza infection and an input to estimates of influenza burden and vaccination impact. However, CRF estimates based on laboratory-confirmed ...

Wang, P., Fu, J., Wu, H. et al. Isolation and characterization of a novel reassortant H3N8 avian influenza virus from chickens in Eastern China. Virus Genes. 2025 Dec 1.  Abstract  
submitted by kickingbird at Dec, 3, 2025 from Virus Genes. 2025 Dec 1 (via https://link.springer.com/article/10.1007/s11262-025-02200-z)
The H3 avian influenza virus (AIV) is a common avian pathogen, widely prevalent among domestic poultry and wild birds. In China, H3N8 AIVs led to two confirmed cases of human infection in 2022, followed ...

Wang, J., Chen, P., Liu, Q. et al. Adaptive mutations in HA of avian H9N2 influenza viruses facilitate their transmission to swine. Vet Res (2025).  Abstract  
submitted by kickingbird at Dec, 3, 2025 from Vet Res (2025) (via https://link.springer.com/article/10.1186/s13567-025-01678-7)
The cross-species transmission of avian H9N2 influenza viruses to swine increases the risk of viral adaptation to mammalian hosts. However, the mechanisms by which these H9 viruses can overcome the barriers ...

WPRO. Avian Influenza Weekly Update # 1024: 28 November 2025. WHO.  Abstract  
submitted by kickingbird at Dec, 1, 2025 from WHO (via https://www.who.int/westernpacific/publications/m/item/avian)
Avian influenza subtype A(HxNy) normally spreads in birds but can also infect humans. Human infections are primarily acquired through direct contact with infected poultry or contaminated environments. ...

Zhang W, Cowling BJ, Tam JSL, Abraham T, Chen H, D. Research Priorities for Zoonotic and Pandemic Influenza Vaccines: Evidence and Recommendations from the WHO Public Health Research Agenda for Influenza (2024 Update). Vaccines. 2025; 13(12):1206.  Abstract  
submitted by kickingbird at Dec, 1, 2025 from Vaccines. 2025; 13(12):1206 (via https://www.mdpi.com/2076-393X/13/12/1206)
Zoonotic influenza viruses, including highly pathogenic avian influenza and swine-origin variants, continue to cause sporadic human infections with, in some cases, high case fatality rates and potential ...

Li W, Shi Y, Li D, Wang Y, Sun Y, Li H, Han Y. A CRISPR Powered Immobilization-Free, Amplification-Free Carbon-Nanotube Field-Effect Transistor (FET) Sensor for Influenza A Virus (IAV). Molecules. 2025; 30(23):4608.  Abstract  
submitted by kickingbird at Dec, 1, 2025 from Molecules. 2025; 30(23):4608 (via https://www.mdpi.com/1420-3049/30/23/4608)
The epidemic of infectious diseases, such as influenza A, has imposed a severe health burden on the population. Early detection, diagnosis, reporting, isolation, and treatment are crucial for the prevention, ...

Zhao Z, Lan N, Chen Y, Yang J, Bai J, Liu J. Changing Epidemiology of Influenza Infections Among Children in the Post-Pandemic Period: A Case Study in Xi’an, China. Vaccines. 2025; 13(12):1214.  Abstract  
submitted by kickingbird at Dec, 1, 2025 from Vaccines. 2025; 13(12):1214 (via https://www.mdpi.com/2076-393X/13/12/1214)
Background: The epidemiology of influenza was disrupted during the COVID-19 pandemic. Following the relaxation of non-pharmaceutical interventions, influenza viruses have re-emerged and caused epidemics ...

Dondi A, Guida F, Trombetta L, De Peppo Cocco M, P. Burden and Clinical Characteristics of Influenza and Its Complications in Children Across Multiple Epidemic Seasons. Viruses. 2025; 17(12):1574.  Abstract  
submitted by kickingbird at Dec, 1, 2025 from Viruses. 2025; 17(12):1574 (via https://www.mdpi.com/1999-4915/17/12/1574)
Seasonal influenza is a major cause of morbidity and hospitalization in children, with the potential for severe complications and considerable socioeconomic impact. We conducted a retrospective observational ...

Baker PH, Glendenning LM, Oliveira MXS, Cobb BA, E. Distribution of sialic acids in the bovine mammary gland across different physiological states. J Dairy Sci. 2025 Nov 27:S0022-0302(25)00977-4.  Abstract  
submitted by kickingbird at Dec, 1, 2025 from J Dairy Sci. 2025 Nov 27:S0022-0302(25)00977-4 (via https://www.journalofdairyscience.org/article/S0022-0302(25))
Highly pathogenic avian influenza (HPAI) A(H5N1) virus emerged in lactating dairy cattle in March 2024, causing mastitis-related disease and infections in other farm animals and workers. Recent work identified ...

Ziqin Song, etc.,al. Dual signal amplification strategy: CRISPR/Cas9 trans-cleavage combined with strand displacement amplification for influenza virus detection. Microchemical Journal.  Abstract  
submitted by kickingbird at Dec, 1, 2025 from Microchemical Journal (via https://www.sciencedirect.com/science/article/abs/pii/S00262)
The core effector protein, Cas9 of the CRISPR/Cas9 system is capable of recognizing and cleaving target DNA sequences under the guidance of guide RNA (gRNA). This study developed a novel platform for detecting ...

Dylan Andrieux, etc.,al. [preprint]Detection and isolation of H5N1 clade 2.3.4.4b high pathogenicity avian influenza virus from ticks (Ornithodoros maritimus) recovered from a naturally infected slender-billed gull (Chroicoce. https://doi.org/10.1101/2025.11.28.689408.  Abstract  
submitted by kickingbird at Nov, 30, 2025 from https://doi.org/10.1101/2025.11.28.689408 (via https://www.biorxiv.org/content/10.1101/2025.11.28.689408v1)
Laridae birds, such as gulls, are known reservoirs of H13 and H16 low pathogenic avian influenza subtypes. However, during the recent outbreaks linked to the reemergence of high pathogenicity avian influenza ...

Hatta, M., Brock, N., Hauguel, T. et al. Influenza mRNA vaccine reduces pathogenicity and transmission of A(H5N1) virus in a ferret model. npj Vaccines (2025).  Abstract  
submitted by kickingbird at Nov, 30, 2025 from npj Vaccines (2025) (via https://link.springer.com/article/10.1038/s41541-025-01318-3)
The global spread of highly pathogenic avian influenza A(H5N1) viruses poses a serious pandemic threat. While sustained human-to-human transmission has not occurred, widespread circulation in birds, increased ...

Rahul K. Nelli, etc.,al. Exploring influenza A virus receptor distribution in the lactating mammary gland of domesticated livestock and in human breast tissue. Journal of Dairy Science.  Abstract  
submitted by kickingbird at Nov, 30, 2025 from Journal of Dairy Science (via https://www.sciencedirect.com/science/article/pii/S002203022)
The spread of the highly pathogenic avian influenza (HPAI) H5N1 virus in dairy cattle, particularly affecting the mammary glands, highlights the adaptability of influenza A viruses (IAV) to infect nontraditional ...

David C. Brice, etc.,al. Immunogenicity and efficacy of commercial poultry avian influenza vaccines against HPAI A(H5N1) clade 2.3.4.4b viruses in Mexico. Virology.  Abstract  
submitted by kickingbird at Nov, 30, 2025 from Virology (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
The high-pathogenicity avian influenza A(H5N1) viruses of clade 2.3.4.4b have been detected in domestic poultry and wild birds in Mexico. Vaccination with H5 vaccines has been implemented as a complementary ...

Nayduch, D., Scroggs, S.L., Shults, P. et al. Detection of H5N1 highly pathogenic avian influenza virus RNA in filth flies collected from California farms in 2024. Sci Rep (2025).  Abstract  
submitted by kickingbird at Nov, 29, 2025 from Sci Rep (2025) (via https://www.nature.com/articles/s41598-025-29856-9)
The emergence of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b in U.S. dairy cattle highlights the urgent need to understand transmission dynamics within and among farms. House flies (Musca ...

Zhang M, Qin L, Li Z, Chen J, Tong J, Ding X, Li H. Dominant substitutions underlying the antigenic evolution of H5 influenza virus. Nat Commun. 2025 Nov 28;16(1):10708.  Abstract  
submitted by kickingbird at Nov, 29, 2025 from Nat Commun. 2025 Nov 28;16(1):10708 (via https://www.nature.com/articles/s41467-025-65730-y)
Highly pathogenic avian influenza (HPAI) H5 viruses have recently been documented in mammals including humans, posing a major threat to global public health. To prevent a potential H5 pandemic, it is critical ...

Pollett SD, Hone E, Richard SA, Schmidt K, Simons. The Epidemiology, Phylogeny, and Strain Antigenicity of an Influenza A/H3N2 Virus Outbreak Among Vaccinated US Navy Midshipmen. Influenza Other Respir Viruses. 2025 Dec;19(12):e7.  Abstract  
submitted by kickingbird at Nov, 29, 2025 from Influenza Other Respir Viruses. 2025 Dec;19(12):e7 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.70184)
We performed epidemiological, genetic, and antigenic characterization of an influenza A/H3N2 outbreak in a congregate setting of young adults with high vaccination rates. We noted substantial duty-days ...

Huang A, Liu Y, Li Y, Yin Z, Huo S, Wang J, Yang Z. Recombinant expression and functional characterization of influenza A virus neuraminidase in a mammalian cell system. Front Microbiol. 2025 Nov 12;16:1729393.  Abstract  
submitted by kickingbird at Nov, 29, 2025 from Front Microbiol. 2025 Nov 12;16:1729393 (via https://www.frontiersin.org/journals/microbiology/articles/1)
The soluble and functional expression of influenza A virus neuraminidase (NA) remains a major challenge due to its membrane-associated nature and structural complexity. In this study, we established a ...

Hongying Chen, etc.,al. [preprint]NSUN2-dependent 5-methylcytosine Modification Regulates Influenza A virus Gene Expression and Genomic Packaging. https://doi.org/10.1101/2025.11.26.690652.  Abstract  
submitted by kickingbird at Nov, 28, 2025 from https://doi.org/10.1101/2025.11.26.690652 (via https://www.biorxiv.org/content/10.1101/2025.11.26.690652v1)
Emerging evidence indicates that methyltransferase NSUN2 catalyzes 5-methylcytosine (m5C) modifications on various viral RNAs and plays important roles in viral biology. However, the regulatory roles of ...

Christopher Ruis, etc.,al. [preprint]Mutational spectra reveal influenza virus transmission routes and adaptation. https://doi.org/10.1101/2025.11.26.690773.  Abstract  
submitted by kickingbird at Nov, 28, 2025 from https://doi.org/10.1101/2025.11.26.690773 (via https://www.biorxiv.org/content/10.1101/2025.11.26.690773v1)
Influenza A virus remains a major cause of morbidity and mortality in humans and animals with pandemic potential. While control of outbreaks and spillover events remains a key health priority, the transmission ...

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