Ghafoori SM, Petersen GF, Conrady DG, Calhoun BM,. Structural characterisation of hemagglutinin from seven Influenza A H1N1 strains reveal diversity in the C05 antibody recognition site. Sci Rep. 2023 Apr 28;13(1):6940. Abstract
submitted by kickingbird at May, 1, 2023 from Sci Rep. 2023 Apr 28;13(1):6940 (via https://www.nature.com/articles/s41598-023-33529-w)
Influenza virus (IV) causes several outbreaks of the flu each year resulting in an economic burden to the healthcare system in the billions of dollars. Several influenza pandemics have occurred during ... Liu L, Madhugiri R, Saul VV, Bacher S, Kracht M, P. Phosphorylation of the PA subunit of influenza polymerase at Y393 prevents binding of the 5´-termini of RNA and polymerase function. Sci Rep. 2023 Apr 29;13(1):7042. Abstract
submitted by kickingbird at May, 1, 2023 from Sci Rep. 2023 Apr 29;13(1):7042 (via https://www.nature.com/articles/s41598-023-34285-7)
The influenza A virus (IAV) polymerase is a multifunctional machine that can adopt alternative configurations to perform transcription and replication of the viral RNA genome in a temporally ordered manner. ... Guo Y, Sun T, Bai X, Liang B, Deng L, Zheng Y, Yu. Comprehensive analysis of the key amino acid substitutions in the polymerase and NP of avian influenza virus that enhance polymerase activity and affect adaptation to mammalian hosts. Vet Microbiol. 2023 Apr 25;282:109760. Abstract
submitted by kickingbird at May, 1, 2023 from Vet Microbiol. 2023 Apr 25;282:109760 (via https://www.sciencedirect.com/science/article/abs/pii/S03781)
Accumulation of adaptive mutations in the polymerase and NP genes is crucial for the adaptation of avian influenza A viruses (IAV) to a new host. Here, we identified residues in the polymerase and NP proteins ... Hui KPY, Ho JCW, Ng KC, Cheng SMS, Sit KY, Au TWK,. Replication of Novel Zoonotic-Like Influenza A(H3N8) Virus in Ex Vivo Human Bronchus and Lung. Emerg Infect Dis. 2023 Apr 24;29(6). Abstract
submitted by kickingbird at Apr, 27, 2023 from Emerg Infect Dis. 2023 Apr 24;29(6) (via https://pubmed.ncbi.nlm.nih.gov/37095078/)
Human infection with avian influenza A(H3N8) virus is uncommon but can lead to acute respiratory distress syndrome. In explant cultures of the human bronchus and lung, novel H3N8 virus showed limited replication ... Bruno A, Alfaro-Nú?ez A, de Mora D, Armas R, Olmed. Phylogenetic analysis reveals that the H5N1 avian influenza A outbreak in poultry in Ecuador in November 2022 is associated to the highly pathogenic clade 2.3.4.4b. Int J Infect Dis. 2023 Apr 20:S1201-9712(23)00533-. Abstract
submitted by kickingbird at Apr, 24, 2023 from Int J Infect Dis. 2023 Apr 20:S1201-9712(23)00533- (via https://www.ijidonline.com/article/S1201-9712(23)00533-7/ful)
The ongoing H5N1 outbreak in the Americas caused by clade 2.3.4.4, is causing unprecedented impact in poultry and wild birds. In November 2022, a highly pathogenic avian influenza A outbreak was declared ... Bhat P, Aksenova V, Gazzara M, Rex EA, Aslam S, Ha. Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex. Nat Commun. 2023 Apr 21;14(1):2304. Abstract
submitted by kickingbird at Apr, 24, 2023 from Nat Commun. 2023 Apr 21;14(1):2304 (via https://www.nature.com/articles/s41467-023-37911-0)
Nuclear export of influenza A virus (IAV) mRNAs occurs through the nuclear pore complex (NPC). Using the Auxin-Induced Degron (AID) system to rapidly degrade proteins, we show that among the nucleoporins ... Guo Z, He Y, Xu J, Benegal AN, Brody SL, Vahey MD. Neuraminidase Activity Modulates Cellular Coinfection during Influenza A Virus Multicycle Growth. mBio. 2023 Apr 20:e0359122. Abstract
submitted by kickingbird at Apr, 24, 2023 from mBio. 2023 Apr 20:e0359122 (via https://journals.asm.org/doi/10.1128/mbio.03591-22)
Infection of individual cells by multiple virions plays critical roles in the replication and spread of many viruses, but mechanisms that control cellular coinfection during multicycle viral growth remain ... Andrews SF, Cominsky LY, Shimberg GD, Gillespie RA. An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans. Sci Transl Med. 2023 Apr 19;15(692):eade4976. Abstract
submitted by kickingbird at Apr, 20, 2023 from Sci Transl Med. 2023 Apr 19;15(692):eade4976 (via https://www.science.org/doi/10.1126/scitranslmed.ade4976)
Current yearly seasonal influenza vaccines primarily induce an antibody response directed against the immunodominant but continually diversifying hemagglutinin (HA) head region. These antibody responses ... Widge AT, Hofstetter AR, Houser KV, Awan SF, Chen. An influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults. Sci Transl Med. 2023 Apr 19;15(692):eade4790. Abstract
submitted by kickingbird at Apr, 20, 2023 from Sci Transl Med. 2023 Apr 19;15(692):eade4790 (via https://www.science.org/doi/10.1126/scitranslmed.ade4790)
Influenza vaccines could be improved by platforms inducing cross-reactive immunity. Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines impedes induction of cross-reactive ... Sun JY, Guo CY, Wang GR, Yan LT, Feng Q, Li Y, Huo. Identification of Heterophilic Epitopes of H1N1 Influenza Virus Hemagglutinin. Curr Microbiol. 2023 Apr 19;80(5):188. Abstract
submitted by kickingbird at Apr, 20, 2023 from Curr Microbiol. 2023 Apr 19;80(5):188 (via https://link.springer.com/article/10.1007/s00284-023-03294-0)
Our previous studies found that the H1-50 monoclonal antibody (mAb) of influenza A virus hemagglutinin (HA) cross-reacted with pancreatic tissue and islet β-cells, and further studies showed that H1-50 ... Daulagala P, Mann BR, Leung K, Lau EHY, Yung L, Le. Imprinted Anti-Hemagglutinin and Anti-Neuraminidase Antibody Responses after Childhood Infections of A(H1N1) and A(H1N1)pdm09 Influenza Viruses. mBio. 2023 Apr 18:e0008423. Abstract
submitted by kickingbird at Apr, 19, 2023 from mBio. 2023 Apr 18:e0008423 (via https://journals.asm.org/doi/10.1128/mbio.00084-23)
Immune imprinting is a driver known to shape the anti-hemagglutinin (HA) antibody landscape of individuals born within the same birth cohort. With the HA and neuraminidase (NA) proteins evolving at different ... Yang J, Zhang Y, Yang L, Li X, Bo H, Liu J, Tan M,. Evolution of Avian Influenza Virus (H3) with Spillover into Humans, China. Emerg Infect Dis. 2023 Apr 17;29(6). Abstract
submitted by kickingbird at Apr, 19, 2023 from Emerg Infect Dis. 2023 Apr 17;29(6) (via https://pubmed.ncbi.nlm.nih.gov/37069608/)
The continuous evolution of avian influenza viruses (AIVs) of subtype H3 in China and the emergence of human infection with AIV subtype H3N8 highlight their threat to public health. Through surveillance ... Guinat C, Tang H, Yang Q, Valenzuela Agüí C, Vaugh. Bayesian phylodynamics reveals the transmission dynamics of avian influenza A(H7N9) virus at the human-live bird market interface in China. Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e221. Abstract
submitted by kickingbird at Apr, 19, 2023 from Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e221 (via https://www.pnas.org/doi/10.1073/pnas.2215610120)
In 2013 to 2017, avian influenza A(H7N9) virus has caused five severe epidemic waves of human infections in China. The role of live bird markets (LBMs) in the transmission dynamics of H7N9 remains unclear. ... Lee CY, Raghunathan V, Caceres CJ, Geiger G, Seibe. Epistasis reduces fitness costs of influenza A virus escape from stem-binding antibodies. Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e220. Abstract
submitted by kickingbird at Apr, 19, 2023 from Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e220 (via https://www.pnas.org/doi/10.1073/pnas.2208718120)
The hemagglutinin (HA) stem region is a major target of universal influenza vaccine efforts owing to the presence of highly conserved epitopes across multiple influenza A virus (IAV) strains and subtypes. ... Igboh LS, Roguski K, Marcenac P, Emukule GO, Charl. Timing of seasonal influenza epidemics for 25 countries in Africa during 2010-19: a retrospective analysis. Lancet Glob Health. 2023 May;11(5):e729-e739. Abstract
submitted by kickingbird at Apr, 17, 2023 from Lancet Glob Health. 2023 May;11(5):e729-e739 (via https://www.thelancet.com/journals/langlo/article/PIIS2214-1)
Background: Using country-specific surveillance data to describe influenza epidemic activity could inform decisions on the timing of influenza vaccination. We analysed surveillance data from African countries ... Zhang H, Xie R, Zhang H, Sun R, Li S, Xia C, Li Z,. Recombinant hemagglutinin protein and DNA-RNA-combined nucleic acid vaccines harbored by yeast elicit protective immunity against H9N2 avian influenza infection. Poult Sci. 2023 Mar 20;102(6):102662.. Abstract
submitted by kickingbird at Apr, 15, 2023 from Poult Sci. 2023 Mar 20;102(6):102662. (via https://www.sciencedirect.com/science/article/pii/S003257912)
A safe, convenience, and effective vaccine for controlling avian influenza virus infection is crucial in scale poultry production. Yeasts are considered useful vaccine vehicles for the delivery of antigens, ... Lee J, Hadfield J, Black A, Sibley TR, Neher RA, B. Joint visualization of seasonal influenza serology and phylogeny to inform vaccine composition. Front Bioinform. 2023 Mar 22;3:1069487. Abstract
submitted by kickingbird at Apr, 14, 2023 from Front Bioinform. 2023 Mar 22;3:1069487 (via https://www.frontiersin.org/articles/10.3389/fbinf.2023.1069)
Seasonal influenza vaccines must be updated regularly to account for mutations that allow influenza viruses to escape our existing immunity. A successful vaccine should represent the genetic diversity ... Pellegrini F, Buonavoglia A, Omar AH, Diakoudi G,. A Cold Case of Equine Influenza Disentangled with Nanopore Sequencing. Animals (Basel). 2023 Mar 24;13(7):1153. Abstract
submitted by kickingbird at Apr, 14, 2023 from Animals (Basel). 2023 Mar 24;13(7):1153 (via https://www.mdpi.com/2076-2615/13/7/1153)
Massive sequencing techniques have allowed us to develop straightforward approaches for the whole genome sequencing of viruses, including influenza viruses, generating information that is useful for improving ... Ala U, Bajardi P, Giacobini M, Bertolotti L. Potential Impact of Environmental Pollution by Human Antivirals on Avian Influenza Virus Evolution. Animals (Basel). 2023 Mar 23;13(7):1127. Abstract
submitted by kickingbird at Apr, 14, 2023 from Animals (Basel). 2023 Mar 23;13(7):1127 (via https://www.mdpi.com/2076-2615/13/7/1127)
Antiviral (AV) drugs are the main line of defense against pandemic influenza. However, different administration policies are applied in countries with different stocks of AV drugs. These policies lead ... Bosco-Lauth A, Rodriguez A, Maison RM, Porter SM,. H7N9 influenza A virus transmission in a multispecies barnyard model. Virology. 2023 Apr 7;582:100-105. Abstract
submitted by kickingbird at Apr, 14, 2023 from Virology. 2023 Apr 7;582:100-105 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza A viruses are a diverse group of pathogens that have been responsible for millions of human and avian deaths throughout history. Here, we illustrate the transmission potential of H7N9 influenza ... 8128 items, 20/Page, Page[66/407][|<<] [|<] [61] [62] [63] [64] [65] [66] [67] [68] [69] [70] [>|] [>>|] |
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