Pan P, Li L, Li Y, Li D, Hou T.. Insights into susceptibility of antiviral drugs against the E119G mutant of 2009 influenza A (H1N1) neuraminidase by molecular dynamics simulations and free energy calculations. Antiviral Res. 2013 Sep 19. Abstract
submitted by kickingbird at Sep, 30, 2013 from Antiviral Res. 2013 Sep 19 (via http://www.ncbi.nlm.nih.gov/pubmed/24055835)
Neuraminidase inhibitors (NAIs) play vital roles in controlling human influenza epidemics and pandemics. However, the emergence of new human influenza virus mutant strains resistant to existing antiviral ... Saranya Sridhar,etc.,al. Cellular immune correlates of protection against symptomatic pandemic influenza. Nature Medicine Year published: (2013) DOI: doi:10. Abstract
submitted by kickingbird at Sep, 23, 2013 from Nature Medicine Year published: (2013) DOI: doi:10 (via http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3350.)
The role of T cells in mediating heterosubtypic protection against natural influenza illness in humans is uncertain. The 2009 H1N1 pandemic (pH1N1) provided a unique natural experiment to determine whether ... ESSERE B, Yver M, Gavazzi C, Terrier O, et al. Critical role of segment-specific packaging signals in genetic reassortment of influenza A viruses. Proc Natl Acad Sci U S A. 2013. Abstract
submitted by kickingbird at Sep, 22, 2013 from Proc Natl Acad Sci U S A. 2013 (via http://www.ncbi.nlm.nih.gov/pubmed/24043788)
The fragmented nature of the influenza A genome allows the exchange of gene segments when two or more influenza viruses infect the same cell, but little is known about the rules underlying this process. ... DONG J, Harada M, Yoshida S, Kato Y, et al. Expression and purification of bioactive hemagglutinin protein of highly pathogenic avian influenza A (H5N1) in silkworm larvae. J Virol Methods. 2013 Sep 13. Abstract
submitted by kickingbird at Sep, 22, 2013 from J Virol Methods. 2013 Sep 13 (via http://www.ncbi.nlm.nih.gov/pubmed/24041500)
The hemagglutinin (HA) of avian influenza viruses plays a very important role in the infection of host cells. In this study, the HA gene of the highly pathogenic avian influenza H5N1 virus was cloned and ... Daihai He, etc.,al. Patterns of spread of influenza A in Canada. Proc. R. Soc. B November 7, 2013 280. Abstract
submitted by kickingbird at Sep, 13, 2013 from Proc. R. Soc. B November 7, 2013 280 (via http://rspb.royalsocietypublishing.org/content/280/1770/2013)
Understanding spatial patterns of influenza transmission is important for designing control measures. We investigate spatial patterns of laboratory-confirmed influenza A across Canada from October 1999 ... Yi Shi, etc.,al. Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses. Science DOI: 10.1126/science.1242917. Abstract
submitted by kickingbird at Sep, 11, 2013 from Science DOI: 10.1126/science.1242917 (via http://www.sciencemag.org/content/early/2013/09/04/science.1)
An avian-origin human-infecting influenza (H7N9) virus has recently been identified in China. Here, we have evaluated the viral hemagglutinin (HA) receptor binding properties from two human H7N9 isolates, ... XU L, Bao L, Deng W, Dong L, et al. The Novel Avian-Origin Human A (H7N9) Influenza Virus Could be Transmitted between Ferrets via Respiratory Droplets. J Infect Dis. 2013 Aug 29.. Abstract
submitted by kickingbird at Sep, 8, 2013 from J Infect Dis. 2013 Aug 29. (via http://www.ncbi.nlm.nih.gov/pubmed/23990570)
The outbreak of human infections caused by the novel avian-origin H7N9 subtype influenza viruses in China since March 2013 underscores the need to better understand the pathogenicityand transmissibility ... CHI Y, Zhu Y, Wen T, Cui L, et al. Cytokine and Chemokine Levels in Patients Infected with the Novel Avian Influenza A (H7N9) Virus in China. J Infect Dis. 2013 Aug 29. Abstract
submitted by kickingbird at Sep, 8, 2013 from J Infect Dis. 2013 Aug 29 (via http://www.ncbi.nlm.nih.gov/pubmed/23990573)
H7N9 avian influenza is an emerging viral disease in China caused by avian influenza A H7N9 virus. We investigated host cytokine and chemokine profiles in serum samples of H7N9 patients by multiplex-microbead ... YANG G, Li S, Blackmon S, Ye J, et al. Mutation tryptophan to leucine at the position 222 of hemagglutinin could facilitate H3N2 influenza A virus infection in dogs. J Gen Virol. 2013 Sep 1. Abstract
submitted by kickingbird at Sep, 8, 2013 from J Gen Virol. 2013 Sep 1 (via http://www.ncbi.nlm.nih.gov/pubmed/23994833)
An avian-like H3N2 influenza A virus (IAV) has recently caused sporadic canine influenza outbreaks in China and Korea, but the molecular mechanisms involved in the interspecies transmission of H3N2 IAV ... ZHANG J, Feng Y, Hu D, Lv H, et al. Rapid and sensitive detection of H7N9 avian influenza virus using reverse transcription loop-mediated isothermal amplification. J Clin Microbiol. 2013 Sep 4. Abstract
submitted by kickingbird at Sep, 8, 2013 from J Clin Microbiol. 2013 Sep 4 (via http://www.ncbi.nlm.nih.gov/pubmed/24006004)
An epidemic of human H7N9 influenza virus infection has recently emerged in China, which was clinically featuring with high mortality and while also resulting in serious economic loss. The novel reassortant ... Adegboye OA, Kotze D.. Epidemiological analysis of spatially misaligned data: a case of highly pathogenic avian influenza virus outbreak in Nigeria. Epidemiol Infect. 2013 Sep 4:1-10. Abstract
submitted by kickingbird at Sep, 8, 2013 from Epidemiol Infect. 2013 Sep 4:1-10 (via http://www.ncbi.nlm.nih.gov/pubmed/24001574)
SUMMARY This research is focused on the epidemiological analysis of the transmission of the highly pathogenic avian influenza (HPAI) H5N1 virus outbreak in Nigeria. The data included 145 outbreaks together ... THARAKARAMAN K, Raman R, Viswanathan K, Stebbins N. Structural determinants for naturally evolving H5N1 hemagglutinin to switch its receptor specificity. Cell. 2013 Jun 20;153(7):1475-85.. Abstract
submitted by kickingbird at Sep, 8, 2013 from Cell. 2013 Jun 20;153(7):1475-85. (via http://www.ncbi.nlm.nih.gov/pubmed/23746829)
Of the factors governing human-to-human transmission of the highly pathogenic avian-adapted H5N1 virus, the most critical is the acquisition of mutations on the viral hemagglutinin (HA) to "quantitatively ... Jason Buehler, etc.,al. Influenza A Virus PB1-F2 Protein Expression Is Regulated in a Strain-Specific Manner by Sequences Located Downstream of the PB1-F2 Initiation Codon. J. Virol. October 2013 vol. 87 no. 19 10687-10699. Abstract
submitted by kickingbird at Sep, 8, 2013 from J. Virol. October 2013 vol. 87 no. 19 10687-10699 (via http://jvi.asm.org/content/87/19/10687.abstract)
Translation of influenza A virus PB1-F2 occurs in a second open reading frame (ORF) of the PB1 gene segment. PB1-F2 has been implicated in regulation of polymerase activity, immunopathology, susceptibility ... Metzger DW, Sun K.. Immune Dysfunction and Bacterial Coinfections following Influenza. J Immunol. 2013;191:2047-52. Abstract
submitted by kickingbird at Aug, 26, 2013 from J Immunol. 2013;191:2047-52 (via http://www.ncbi.nlm.nih.gov/pubmed/23964104)
Secondary pulmonary infections by encapsulated bacteria including Streptococcus pneumoniae and Staphylococcus aureus following influenza represent a common and challenging clinical problem. The reasons ... RAMOS I, Krammer F, Hai R, Aguilera D, et al. H7N9 influenza viruses interact preferentially with α2,3-linked sialic acids and bind weakly to α2,6-linked sialic acids.. J Gen Virol. 2013 Aug 15. Abstract
submitted by kickingbird at Aug, 26, 2013 from J Gen Virol. 2013 Aug 15 (via http://www.ncbi.nlm.nih.gov/pubmed/23950563)
The recent human outbreak of H7N9 avian influenza A virus has caused worldwide concerns. Receptor binding specificity is critical for viral pathogenicity, and still not thoroughly studied for this emerging ... DE DONNO A, Idolo A, Quattrocchi M, Zizza A, et al. Surveillance of human influenza A(H3N2) virus from 1999 to 2009 in southern Italy. Epidemiol Infect. 2013 Aug 22:1-7.. Abstract
submitted by kickingbird at Aug, 26, 2013 from Epidemiol Infect. 2013 Aug 22:1-7. (via http://www.ncbi.nlm.nih.gov/pubmed/23967903)
SUMMARY The aim of this study was to evaluate the presence of influenza virus co-infections in humans and changes in the genetic variability of A(H3N2) virus strains in southern Italy from 1999 to 2009. ... WAUGH T, Ching JC, Zhou Y, Loewen ME, et al. Influenza A virus (H1N1) increases airway epithelial cell secretion by up-regulation of potassium channel KCNN4.. Biochem Biophys Res Commun. 2013 Aug 13. pii: S000. Abstract
submitted by kickingbird at Aug, 26, 2013 from Biochem Biophys Res Commun. 2013 Aug 13. pii: S000 (via http://www.ncbi.nlm.nih.gov/pubmed/23954634)
Influenza infects the epithelial cells lining the airways. Normally epithelial cells move solutes through ion channels to create the osmotic drive to hydrate the airways. Viral alteration of this process ... Tsan-Yuk Lam, T. et al. The genesis and source of the H7N9 influenza viruses causing human infections in China. Nature (2013) doi:10.1038/nature12515. Abstract
submitted by kickingbird at Aug, 22, 2013 from Nature (2013) doi:10.1038/nature12515 (via http://www.nature.com/nature/journal/vaop/ncurrent/full/natu)
A novel H7N9 influenza A virus first detected in March 2013 has since caused more than 130 human infections in China, resulting in 40 deaths. Preliminary analyses suggest that the virus is a reassortant of H7, N9 and H9N2 avian influenza viruses, and carries some amino acids associated with mammalian receptor binding, raising concerns of a new pandemic. However, neither the source populations of the H7N9 outbreak lineage nor the conditions for its genesis are fully known. Using a combination of active surveillance, screening of virus archives, and evolutionary analyses, here we show that H7 viruses probably transferred from domestic duck to chicken populations in China on at least two independent occasions. We show that the H7 viruses subsequently reassorted with enzootic H9N2 viruses to generate the H7N9 outbreak lineage, and a related previously unrecognized H7N7 lineage. The H7N9 outbreak lineage has spread over a large geographic region and is prevalent in chickens at live poultry markets, which are thought to be the immediate source of human infections. Whether the H7N9 outbreak lineage has, or will, become enzootic in China and neighbouring regions requires further investigation. The discovery here of a related H7N7 influenza virus in chickens that has the ability to infect mammals experimentally, suggests that H7 viruses may pose threats beyond the current outbreak. The continuing prevalence of H7 viruses in poultry could lead to the generation of highly pathogenic variants and further sporadic human infections, with a continued risk of the virus acquiring human-to-human transmissibility. REDFORD PS, Mayer-Barber KD, McNab FW, Stavropoulo. Influenza A virus impairs control of Mycobacterium tuberculosis co-infection through a Type I Interferon receptor dependent pathway. J Infect Dis. 2013 Aug 9. Abstract
submitted by kickingbird at Aug, 20, 2013 from J Infect Dis. 2013 Aug 9 (via http://www.ncbi.nlm.nih.gov/pubmed/23935205)
Influenza, followed by severe acute bacterial pneumonia, is a major cause of mortality worldwide. Several mechanisms account for this enhanced susceptibility, including increased production of Type I IFN. ... HARA K, Nakazono Y, Kashiwagi T, Hamada N, et al. Co-incorporation of the PB2 and PA polymerase subunits from human H3N2 influenza virus is a critical determinant of the replication of reassortant ribonucleoprotein complexes. J Gen Virol. 2013 Aug 12.. Abstract
submitted by kickingbird at Aug, 20, 2013 from J Gen Virol. 2013 Aug 12. (via http://www.ncbi.nlm.nih.gov/pubmed/23939981)
The influenza virus RNA polymerase, composed of the PB1, PB2, and PA subunits, has a potential role in influencing genetic reassortment. Recent studies on the reassortment of human H3N2 strains suggest ... 8128 items, 20/Page, Page[296/407][|<<] [|<] [291] [292] [293] [294] [295] [296] [297] [298] [299] [300] [>|] [>>|] |
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