LIU Q, Chen H, Huang J, Chen Y, et al. A nonpathogenic duck-origin H9N2 influenza A virus adapts to high pathogenicity in mice. Arch Virol. 2014. Abstract
submitted by kickingbird at Apr, 6, 2014 from Arch Virol. 2014 (via http://www.ncbi.nlm.nih.gov/m/pubmed/24696271/)
H9N2 influenza viruses continue to circulate in wild birds and poultry in Eurasian countries and have repeatedly infected mammals, including pigs and humans, posing a significant threat to public health. ... WU R, Li X, Leung HC, Cao Z, et al.. A novel neutralizing antibody against diverse clades of H5N1 influenza virus and its mutants capable of airborne transmission. Antiviral Res. 2014 Mar 25. pii: S0166-3542(14)000. Abstract
submitted by kickingbird at Apr, 6, 2014 from Antiviral Res. 2014 Mar 25. pii: S0166-3542(14)000 (via http://www.ncbi.nlm.nih.gov/m/pubmed/24681124/)
Highly pathogenic avian influenza A virus H5N1 continues to spread among poultry and has frequently broken the species barrier to humans. Recent studies have shown that a laboratory-mutated or reassortant ... SCHERLIESS R, Ajmera A, Dennis M, Carroll MW, et a. Induction of protective immunity against H1N1 influenza A(H1N1)pdm09 with spray-dried and electron-beam sterilised vaccines in non-human primates. Vaccine. 2014 Mar 11. pii: S0264-410X(14)00140. Abstract
submitted by kickingbird at Mar, 23, 2014 from Vaccine. 2014 Mar 11. pii: S0264-410X(14)00140 (via http://www.ncbi.nlm.nih.gov/pubmed/24631078)
Currently, the need for cooled storage and the impossibility of terminal sterilisation are major drawbacks in vaccine manufacturing and distribution. To overcome current restrictions a preclinical safety ... YAN J, Villarreal DO, Racine T, Chu JS, et al. Protective immunity to H7N9 influenza viruses elicited by synthetic DNA vaccine.. Vaccine. 2014 Mar 11. pii: S0264-410X(14)00211. Abstract
submitted by kickingbird at Mar, 23, 2014 from Vaccine. 2014 Mar 11. pii: S0264-410X(14)00211 (via http://www.ncbi.nlm.nih.gov/pubmed/24631084)
Despite an intensive vaccine program influenza infections remain a major health problem, due to the viruses' ability to change its envelope glycoprotein hemagglutinin (HA), through shift and drift, permitting ... BANJAC M, Roethl E, Gelhart F, Kramberger P, et al. Purification of Vero cell derived live replication deficient influenza A and B virus by ion exchange monolith chromatography. Vaccine. 2014 Mar 11. pii: S0264-410X(14)00313. Abstract
submitted by kickingbird at Mar, 23, 2014 from Vaccine. 2014 Mar 11. pii: S0264-410X(14)00313 (via http://www.ncbi.nlm.nih.gov/pubmed/24631091)
We explored the possibilities for purification of various ΔNS1 live, replication deficient influenza viruses on ion exchange methacrylate monoliths. Influenza A ΔNS1-H1N1, ΔNS1-H3N2, ΔNS1-H5N1 and ΔNS1-influenza ... KIM H, Schoofs P, Anderson DA, Tannock GA, et al. Cold adaptation improves the growth of seasonal influenza B vaccine viruses. Vaccine. 2014 Mar 11. pii: S0264-410X(14)00306. Abstract
submitted by kickingbird at Mar, 23, 2014 from Vaccine. 2014 Mar 11. pii: S0264-410X(14)00306 (via http://www.ncbi.nlm.nih.gov/pubmed/24631096)
Gene reassortment has proved useful in improving yields of influenza A antigens of egg-based inactivated vaccines, but similar approaches have been difficult with influenza B antigens. Current regulations ... KANDEIL A, Bagato O, Zaraket H, Debeauchamp J, et. Proteolytic enzymes in embryonated chicken eggs sustain the replication of egg-grown low-pathogenicity avian influenza viruses in cells in the absence of exogenous proteases. J Virol Methods. 2014 Mar 10. pii: S0166-0934. Abstract
submitted by kickingbird at Mar, 23, 2014 from J Virol Methods. 2014 Mar 10. pii: S0166-0934 (via http://www.ncbi.nlm.nih.gov/pubmed/24626064)
Low pathogenic influenza viruses grow readily in embryonated chicken eggs but require the addition of exogenous proteases to grow in MDCK cell culture. In this study, we found that the influenza viruses ... FULLER T, Havers F, Xu C, Fang LQ, et al. Identifying areas with a high risk of human infection with the avian influenza a (H7N9) virus in east asia. J Infect. 2014 Mar 15. pii: S0163-4453(14)00076.. Abstract
submitted by kickingbird at Mar, 23, 2014 from J Infect. 2014 Mar 15. pii: S0163-4453(14)00076. (via http://www.ncbi.nlm.nih.gov/pubmed/24642206)
OBJECTIVES:
The rapid emergence, spread, and disease severity of avian influenza A(H7N9) in China has prompted concerns about a possible pandemic and regional spread in the coming months. The objective ... Jiankang Han, Lili Wang, Jia Liu, Meihua Jin, Fang. Co-circulation of three HA and two NA subtypes of avian influenza viruses in Huzhou, China, April 2013: implication for the origin of the novel H7N9 virus. JVI.03319-13. Abstract
submitted by kickingbird at Mar, 20, 2014 from JVI.03319-13 (via http://jvi.asm.org/content/early/2014/03/06/JVI.03319-13.abs)
We detected three avian influenza HA subtypes (H7, H9 and H5) and two NA subtypes (N9 and N2), as well as H7N9-related reassortant intermediates H9N9, co-circulating among poultry in Huzhou, China, during ... Zhimin Wan, Jianqiang Ye, Liangliang Xu, Hongxia S. Antigenic Mapping of the Hemagglutinin of an H9N2 Avian Influenza Virus Reveals Novel Critical Amino Acid Positions in Antigenic Sites. J. Virol. April 2014 vol. 88 no. 7 3898-3901. Abstract
submitted by kickingbird at Mar, 20, 2014 from J. Virol. April 2014 vol. 88 no. 7 3898-3901 (via http://jvi.asm.org/content/88/7/3898.abstract)
H9N2 influenza virus is undergoing extensive genetic and antigenic evolution, warranting detailed antigenic mapping of its hemagglutinin (HA). Through examining antibody escape mutants of an Asian avian ... Patricia J. Campbell, Shamika Danzy, Constantinos. The M Segment of the 2009 Pandemic Influenza Virus Confers Increased Neuraminidase Activity, Filamentous Morphology, and Efficient Contact Transmissibility to A/Puerto Rico/8/1934-Based Reassortant Vi. J. Virol. April 2014 vol. 88 no. 7 3802-3814. Abstract
submitted by kickingbird at Mar, 20, 2014 from J. Virol. April 2014 vol. 88 no. 7 3802-3814 (via http://jvi.asm.org/content/88/7/3802.abstract)
The 2009 H1N1 lineage represented the first detection of a novel, highly transmissible influenza A virus genotype: six gene segments originated from the North American triple-reassortant swine lineage, ... Lee YJ, Kang HM, Lee EK, Song BM, Jeong J, Kwon YK. Novel Reassortant Influenza A(H5N8) Viruses, South Korea, 2014. Emerg Infect Dis. 2014 Jun. Full Text
submitted by kickingbird at Mar, 17, 2014 from Emerg Infect Dis. 2014 Jun (via http://wwwnc.cdc.gov/eid/article/20/6/14-0233_article.htm)
Highly pathogenic avian influenza (HPAI) viruses have caused considerable economic losses to the poultry industry and poses potential threats to animal and human health (www.oie.int/en/ and www.who.int/en/). ... SUN Y, Xu Q, Shen Y, Liu L, et al. Naturally occurring mutations in the PA gene are key contributors to increased virulence of pandemic H1N1/09 influenza virus in mice.. J Virol. 2014. Abstract
submitted by kickingbird at Feb, 16, 2014 from J Virol. 2014 (via http://www.ncbi.nlm.nih.gov/pubmed/24522908)
We examined the molecular basis of virulence of pandemic H1N1/09 influenza viruses by reverse genetics based on two H1N1/09 virus isolates (A/California/04/2009 [CA04] and A/swine/Shandong/731/2009 [SD731]) ... TARNOW C, Engels G, Arendt A, Schwalm F, et al. TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice. J Virol. 2014 Feb 12. Abstract
submitted by kickingbird at Feb, 16, 2014 from J Virol. 2014 Feb 12 (via http://www.ncbi.nlm.nih.gov/pubmed/24522916)
Cleavage of the hemagglutinin (HA) by host proteases is essential for the infectivity of influenza viruses. We have analysed here the role of the serine protease TMPRSS2 activating HA in the human respiratory ... NEUMANN G, Macken CA, Kawaoka Y. Identification of amino acid changes that may have been critical for the genesis of A(H7N9) influenza viruses. J Virol. 2014 Feb 12. Abstract
submitted by kickingbird at Feb, 16, 2014 from J Virol. 2014 Feb 12 (via http://www.ncbi.nlm.nih.gov/pubmed/24522919)
Novel influenza A viruses of the H7N9 subtype [A(H7N9)] emerged in the spring of 2013 in China and have infected 163 people as of January 10, 2014; fifty of them died of the severe respiratory infection ... YANG H, Chang JC, Guo Z, Carney PJ, et al. Structural stability of influenza A(H1N1)pdm09 virus hemagglutinins. J Virol. 2014 Feb 12.. Abstract
submitted by kickingbird at Feb, 16, 2014 from J Virol. 2014 Feb 12. (via http://www.ncbi.nlm.nih.gov/pubmed/24522930)
The non-covalent interactions that mediate trimerization of the influenza hemagglutinin (HA) are important determinants of its biological activities. Recent studies have demonstrated that mutations in ... HE L, Wu Q, Jiang K, Duan Z, et al. Differences in transmissibility and pathogenicity of reassortants between H9N2 and 2009 pandemic H1N1 influenza A viruses from humans and swine. Arch Virol. 2014 Feb 9. Abstract
submitted by kickingbird at Feb, 16, 2014 from Arch Virol. 2014 Feb 9 (via http://www.ncbi.nlm.nih.gov/pubmed/24510170)
Both H9N2 subtype avian influenza and 2009 pandemic H1N1 viruses (pH1N1) can infect humans and pigs, which provides the opportunity for virus reassortment, leading to the genesis of new strains with potential ... IVACHTCHENKO AV, Ivanenkov YA, Mitkin OD, Yamanush. A novel influenza virus neuraminidase inhibitor AV5027. Antiviral Res. 2013 Oct 24. pii: S0166-3542. Abstract
submitted by kickingbird at Feb, 16, 2014 from Antiviral Res. 2013 Oct 24. pii: S0166-3542 (via http://www.ncbi.nlm.nih.gov/pubmed/24513312)
A medium-sized focused library of novel Oseltamivir structural analogues with promising antiviral activity was successfully synthesized using a combinatorial approach. The synthesized compounds were then ... SH Wei, etc.,al. Human infection with avian influenza A H6N1 virus: an epidemiological analysis. The Lancet Respiratory Medicine, Volume 1, Issue. Abstract
submitted by kickingbird at Feb, 5, 2014 from The Lancet Respiratory Medicine, Volume 1, Issue (via http://www.thelancet.com/journals/lanres/article/PIIS2213-26)
Background
Avian influenza A H6N1 virus is one of the most common viruses isolated from wild and domestic avian species, but human infection with this virus has not been previously reported. We report ... Chen H, Yuan H, Gao R, et al. Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study. Lancet 2014 (published online Feb 4). Abstract
submitted by kickingbird at Feb, 5, 2014 from Lancet 2014 (published online Feb 4) (via http://www.thelancet.com/journals/lancet/article/PIIS0140-67)
Background
Human infections with different avian influenza viruses—eg, H5N1, H9N2, and H7N9—have raised concerns about pandemic potential worldwide. We report the first human infection with a novel ... 8128 items, 20/Page, Page[292/407][|<<] [|<] [291] [292] [293] [294] [295] [296] [297] [298] [299] [300] [>|] [>>|] |
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