Harvala H, Smith D, Salvatierra K, Gunson R, von W. Burden of influenza B virus infections in Scotland in 2012/13 and epidemiological investigations between 2000 and 2012. Eurosurveillance, Volume 19, Issue 37,. Abstract
submitted by kickingbird at Sep, 19, 2014 from Eurosurveillance, Volume 19, Issue 37, (via http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=2)
We describe the burden of influenza B infections in Scotland during a 13-year study period. Influenza A and B viruses cocirculated throughout the period, with numbers of influenza B cases approaching or ... SVANCAROVA P, Svetlikova D, Betakova T. Synergic and antagonistic effect of small hairpin RNAs targeting the NS gene of the influenza A virus in cells and mice. Virus Res. 2014 Sep 3. pii: S0168-1702. Abstract
submitted by kickingbird at Sep, 15, 2014 from Virus Res. 2014 Sep 3. pii: S0168-1702 (via http://www.ncbi.nlm.nih.gov/pubmed/25192613)
In the present study, we demonstrate the effect of individual and mixtures of shRNAs targeting the NS gene to treat an established infection of influenza A virus (IAV). We prepared 10 shRNAs targeting ... HILLAIRE ML, van Eijk M, Vogelzang-van Trierum SE,. Assessment of the antiviral properties of recombinant surfactant protein D against influenza B virus in vitro. Virus Res. 2014 Sep 5. Abstract
submitted by kickingbird at Sep, 15, 2014 from Virus Res. 2014 Sep 5 (via http://www.ncbi.nlm.nih.gov/pubmed/25200748)
The armamentarium of antiviral drugs against influenza viruses is limited. Furthermore, influenza viruses emerge that are resistant to existing antiviral drugs like the M2 and NA inhibitors. Therefore, ... CHENG K, Yu Z, Chai H, Sun W, et al. PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice. Virology. 2014 Sep 3;468-470C:207-213.. Abstract
submitted by kickingbird at Sep, 15, 2014 from Virology. 2014 Sep 3;468-470C:207-213. (via http://www.ncbi.nlm.nih.gov/pubmed/25194918)
H6N1 avian influenza viruses (AIVs) may pose a potential human risk as suggested by the first documented naturally-acquired human H6N1 virus infection in 2013. Here, we set out to elucidate viral determinants ... OTHUMPANGAT S, Noti JD, Beezhold DH. Lung epithelial cells resist influenza A infection by inducing the expression of cytochrome c oxidase VIc which is modulated by miRNA 4276. Virology. 2014 Sep 6;468-470C:256-264.. Abstract
submitted by kickingbird at Sep, 15, 2014 from Virology. 2014 Sep 6;468-470C:256-264. (via http://www.ncbi.nlm.nih.gov/pubmed/25203353)
Influenza virus infection induces several changes in host miRNA profile, host cell death and tissue damage. Cytochrome c is a regulator of the intrinsic apoptotic pathway and is altered during viral infections. ... LIU W, Fan H, Raghwani J, Tsan-Yuk Lam T, et al. Occurrence and reassortment of avian influenza A (H7N9) viruses derived from coinfected birds in China. J Virol. 2014 Sep 10. pii: JVI.01777-14.. Abstract
submitted by kickingbird at Sep, 15, 2014 from J Virol. 2014 Sep 10. pii: JVI.01777-14. (via http://www.ncbi.nlm.nih.gov/pubmed/25210174)
Over the course of two waves of infection, H7N9 avian influenza A virus has caused 436 human infections and claimed 170 lives in China as of July 2014. To investigate the prevalence and genetic diversity ... DANZY S, Studdard LR, Manicassamy B, Solorzano A,. Mutations to PB2 and NP proteins of an avian influenza virus combine to confer efficient growth in primary human respiratory cells. J Virol. 2014 Sep 10. pii: JVI.01093-14.. Abstract
submitted by kickingbird at Sep, 15, 2014 from J Virol. 2014 Sep 10. pii: JVI.01093-14. (via http://www.ncbi.nlm.nih.gov/pubmed/25210184)
Influenza pandemics occur when influenza A viruses (IAV) adapted to other host species enter humans and spread through the population. Pandemics are relatively rare due to host restriction of IAV: strains ... MELIOPOULOS VA, Karlsson EA, Kercher L, Cline T, e. Human H7N9 and H5N1 influenza viruses differ in induction of cytokines and tissue tropism. J Virol. 2014 Sep 10. pii: JVI.01571-14. Abstract
submitted by kickingbird at Sep, 15, 2014 from J Virol. 2014 Sep 10. pii: JVI.01571-14 (via http://www.ncbi.nlm.nih.gov/pubmed/25210188)
Since emerging in 2013, the avian-origin H7N9 influenza viruses have resulted in over 400 human infections leading to 115 deaths to date. Although the epidemiology differs from human highly pathogenic ... RITH S, Davis CT, Duong V, Sar B, et al. Identification of molecular markers associated with alteration of receptor-binding specificity in a novel genotype of highly pathogenic avian influenza A(H5N1) viruses detected in Cambodia in 2013. J Virol. 2014 Sep 10. pii: JVI.01887-14.. Abstract
submitted by kickingbird at Sep, 15, 2014 from J Virol. 2014 Sep 10. pii: JVI.01887-14. (via http://www.ncbi.nlm.nih.gov/pubmed/25210193)
Human infections with influenza A(H5N1) virus in Cambodia increased sharply during 2013. Molecular characterization of viruses detected in clinical specimens from human cases revealed the presence of mutations ... Matloob Husain and Chen-Yi Cheung. Histone Deacetylase 6 Inhibits Influenza A Virus Release by Downregulating the Trafficking of Viral Components to the Plasma Membrane via Its Substrate, Acetylated Microtubules. J. Virol. October 2014 vol. 88 no. 19 11229-11239. Abstract
submitted by kickingbird at Sep, 12, 2014 from J. Virol. October 2014 vol. 88 no. 19 11229-11239 (via http://jvi.asm.org/content/88/19/11229.abstract?sid=e1317f1f)
Mammalian cells produce many proteins, such as IFITM3, ISG15, MxA, and viperin, that inhibit influenza A virus (IAV) infection. Here, we show that a new class of host protein, histone deacetylase 6 (HDAC6), ... Caselton DL, Arunga G, Emukule G, Muthoka P, Mayie. Does the length of specimen storage affect influenza testing results by real-time reverse transcription-polymerase chain reaction? An analysis of influenza surveillance specimens, 2008 to 2010. Euro Surveill. 2014;19(36):pii=20893.. Abstract
submitted by kickingbird at Sep, 12, 2014 from Euro Surveill. 2014;19(36):pii=20893. (via http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=2)
In some influenza surveillance systems, timely transport to laboratories for reverse transcription-polymerase chain reaction (RT-PCR) testing is challenging. Guidelines suggest that samples can be stored ... YORK A, Hutchinson EC, Fodor E. Interactome analysis of the influenza A virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication. J Virol. 2014 Sep 3. pii:. Abstract
submitted by kickingbird at Sep, 7, 2014 from J Virol. 2014 Sep 3. pii: (via http://www.ncbi.nlm.nih.gov/pubmed/25187537)
The negative-sense RNA genome of influenza A virus is transcribed and replicated by the viral RNA-dependent RNA polymerase (RdRP). The viral RdRP is an important host range determinant, indicating that ... MAIR CM, Meyer T, Schneider K, Huang Q, et al. A histidine residue of the influenza virus hemagglutinin controls the pH dependence of the conformational change mediating membrane fusion. J Virol. 2014 Sep 3. pii: JVI.01704-14. Abstract
submitted by kickingbird at Sep, 7, 2014 from J Virol. 2014 Sep 3. pii: JVI.01704-14 (via http://www.ncbi.nlm.nih.gov/pubmed/25187542)
The conformational change of the influenza virus hemagglutinin (HA) protein mediating the fusion between the virus envelope and the endosomal membrane was hypothesized to be induced by protonation of specific ... Marc D.. Influenza virus non-structural protein NS1: interferon-antagonism and beyond. J Gen Virol. 2014 Sep 2. Abstract
submitted by kickingbird at Sep, 7, 2014 from J Gen Virol. 2014 Sep 2 (via http://www.ncbi.nlm.nih.gov/pubmed/25182164)
Most viruses express one or several proteins that counter the anti-viral defences of the host-cell. This is the task of non-structural protein NS1 in influenza viruses. Absent from the viral particle but ... Colvin MT, Andreas LB, Chou JJ, Griffin RG.. Proton Association Constants of His-37 in the Influenza-A M218-60 Dimer-of-Dimers. Biochemistry. 2014 Sep 3. Abstract
submitted by kickingbird at Sep, 7, 2014 from Biochemistry. 2014 Sep 3 (via http://www.ncbi.nlm.nih.gov/pubmed/25184631)
The membrane protein M2 from influenza-A forms a single pass transmembrane helix that assembles in lipid membrane as homo-tetramers whose primary function is to act as a proton gate for viral acidification. ... ZHANG C, Wu Y, Xuan Z, Zhang S, et al. p38MAPK, Rho/ROCK and PKC pathways are involved in influenza-induced cytoskeletal rearrangement and hyperpermeability in PMVEC via phosphorylating ERM. Virus Res. 2014 Aug 19. pii: S0168-1702(14)00305-0. Abstract
submitted by kickingbird at Aug, 30, 2014 from Virus Res. 2014 Aug 19. pii: S0168-1702(14)00305-0 (via http://www.ncbi.nlm.nih.gov/pubmed/25150189)
Severe influenza infections are featured by acute lung injury, a syndrome of pulmonary microvascular leak. A growing number of evidences have shown that the pulmonary microvascular endothelial cells (PMVEC) ... WONG SS, Yoon SW, Zanin M, Song MS, et al. Characterization of an H4N2 influenza virus from Quails with a multibasic motif in the hemagglutinin cleavage site. Virology. 2014 Aug 20;468-470C:72-80. doi: 10.1016. Abstract
submitted by kickingbird at Aug, 30, 2014 from Virology. 2014 Aug 20;468-470C:72-80. doi: 10.1016 (via http://www.ncbi.nlm.nih.gov/pubmed/25151061)
The cleavage motif in the hemagglutinin (HA) protein of highly pathogenic H5 and H7 subtypes of avian influenza viruses is characterized by a peptide insertion or a multibasic cleavage site (MBCS). Here, ... STAUFFER S, Feng Y, Nebioglu F, Heilig R, et al. Stepwise priming by acidic pH and high K+ is required for efficient uncoating of influenza A virus cores after penetration. J Virol. 2014 Aug 27. pii: JVI.01430-14. Abstract
submitted by kickingbird at Aug, 30, 2014 from J Virol. 2014 Aug 27. pii: JVI.01430-14 (via http://www.ncbi.nlm.nih.gov/pubmed/25165113)
Influenza A virus uses the low pH in late endocytic vacuoles as a cue for penetration by membrane fusion. Here, we analyzed the pre-fusion reactions that prepare the core for uncoating after it has been ... POOLE DS, Yu SN, Cai Y, Dinis JM, et al. Influenza A Virus Polymerase Is a Site for Adaptive Changes During Experimental Evolution in Bat Cells. J Virol. 2014 Aug 20. Abstract
submitted by kickingbird at Aug, 25, 2014 from J Virol. 2014 Aug 20 (via http://www.ncbi.nlm.nih.gov/pubmed/25142579)
The recent identification of highly divergent influenza A viruses in bats revealed a new, geographically dispersed viral reservoir. To investigate the molecular mechanisms of host-restricted viral tropism ... MARJUKI H, Mishin VP, Chesnokov AP, Jones J, et al. Characterization of Drug-Resistant Influenza A(H7N9) Variant Viruses Isolated from an Oseltamivir-Treated Patient in Taiwan. J Infect Dis. 2014 Aug 14.. Abstract
submitted by kickingbird at Aug, 25, 2014 from J Infect Dis. 2014 Aug 14. (via http://www.ncbi.nlm.nih.gov/pubmed/25124927)
BACKGROUND:
?Patients contracting influenza A(H7N9) often developed severe disease causing respiratory failure. Neuraminidase (NA) inhibitors (NAIs) are the primary option for treatment, but information ... 8128 items, 20/Page, Page[286/407][|<<] [|<] [281] [282] [283] [284] [285] [286] [287] [288] [289] [290] [>|] [>>|] |
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