Yu Z, Cheng K, Sun W, Zhang X, et al. Multiple adaptive amino acid substitutions increase the virulence of a wild waterfowl-origin reassortant H5N8 avian influenza virus in mice. Virus Res 2017 Nov 4. Abstract
submitted by kickingbird at Nov, 13, 2017 from Virus Res 2017 Nov 4 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29113821/)
A novel H5N8 highly pathogenic avian influenza virus (HPAIV) caused poultry outbreaks in the Republic of Korea in 2014. The novel H5N8 HPAIV has spread to Asia, Europe, and North America and caused great ... Ni Y, Guo J, Turner D, Tizard I, et al. Development of a novel dual-domain nanoparticle antigen construct for universal influenza vaccine. Vaccine 2017 Oct 25. Abstract
submitted by kickingbird at Nov, 13, 2017 from Vaccine 2017 Oct 25 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29102171/)
A highly effective antigen construct for presenting conserved antigen domains is essential to the development of a universal influenza vaccine. We have developed a novel dual-domain nanoparticle fusion ... Zost SJ, Parkhouse K, Gumina ME, Kim K, et al. Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains. Proc Natl Acad Sci U S A 2017 Nov 6. Abstract
submitted by kickingbird at Nov, 13, 2017 from Proc Natl Acad Sci U S A 2017 Nov 6 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29109276/)
H3N2 viruses continuously acquire mutations in the hemagglutinin (HA) glycoprotein that abrogate binding of human antibodies. During the 2014-2015 influenza season, clade 3C.2a H3N2 viruses possessing ... Kok TW, Costabile M, Tannock GA, Li P, et al. Colocalization of intracellular specific IgA (icIgA) with influenza virus in patients´ nasopharyngeal aspirate cells. J Virol Methods 2017 Nov 1. Abstract
submitted by kickingbird at Nov, 13, 2017 from J Virol Methods 2017 Nov 1 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29102516/)
Inhibition of viral replication by icIgA antibodies has only been observed with in vitro studies using epithelial cell lines in transwell cultures. This effect appears to involve an interaction between ... Wen F, Li L, Zhao N, Chiang MJ, et al. A Y161F Hemagglutinin Substitution Increases Thermostability and Improves Yields of 2009 H1N1 influenza A Virus in Cells. J Virol 2017 Nov 8. Abstract
submitted by kickingbird at Nov, 13, 2017 from J Virol 2017 Nov 8 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29118117/)
Vaccination is the primary strategy for influenza prevention and control. Yet egg-based vaccines, the predominant production platform, have several disadvantages including the emergence of viral antigenic ... Oymans J, Te Velthuis AJW. A mechanism for prime-realignment during influenza A virus replication. J Virol 2017 Nov 8. Abstract
submitted by kickingbird at Nov, 13, 2017 from J Virol 2017 Nov 8 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29118119/)
The influenza A virus genome consists of eight segments of single-stranded RNA. These segments are replicated and transcribed by a viral RNA-dependent RNA polymerase (RdRp) that is made up of the influenza ... Sakai T, Takagi H, Muraki Y, Saito M, et al. Unique directional motility of influenza C virus controlled by its filamentous morphology and short-range motions. J Virol 2017 Nov 8. Abstract
submitted by kickingbird at Nov, 13, 2017 from J Virol 2017 Nov 8 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29118122/)
Influenza virus motility is based on cooperation between two viral spike proteins, hemagglutinin (HA) and neuraminidase (NA), and is a major determinant of virus infectivity. To translocate a virus particle ... Wong SS, Oshansky CM, Guo XJ, Ralston J, et al. Severe influenza is characterized by prolonged immune activation: results from the SHIVERS cohort study. J Infect Dis 2017 Nov 3. Abstract
submitted by kickingbird at Nov, 13, 2017 from J Infect Dis 2017 Nov 3 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29112724/)
Background: The immunologic factors underlying severe influenza are poorly understood. To address this, we compared the immune responses of influenza-confirmed hospitalized individuals with severe acute ... Kim MC, Lee YN, Kim YJ, Choi HJ, et al. Immunogenicity and efficacy of replication-competent recombinant influenza virus carrying multimeric M2 extracellular domains in a chimeric hemagglutinin conjugate. Antiviral Res 2017;148:43-52. Abstract
submitted by kickingbird at Nov, 13, 2017 from Antiviral Res 2017;148:43-52 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29107058/)
Current influenza vaccines provide hemagglutinin (HA) strain-specific protection. To improve cross protection, we engineered replication-competent influenza A virus to express tandem repeats of heterologous ... Pei JX, Qin JQ, Nong H, etc.,al. Genetic characterization of a highly pathogenic avian influenza A(H7N9) virus strain isolated in Nanning city. China Public Health. Abstract
submitted by kickingbird at Nov, 19, 2017 from China Public Health (via http://kns.cnki.net/kcms/detail/21.1234.R.20171020.1323.016.)
To analyze the traceability and genetic characteristics of a highly pathogenic H7N9 avian influenza virus strain isolated in Nanning city, 2017 through sequencing of HA and NA gene of the virus. Both HA ... Wohlgemuth N, Ye Y, Fenstermacher KJ, Liu H, et al. The M2 protein of live, attenuated influenza vaccine encodes a mutation that reduces replication in human nasal epithelial cells. Vaccine 2017 Oct 24. Abstract
submitted by kickingbird at Nov, 6, 2017 from Vaccine 2017 Oct 24 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29079099/)
The influenza A virus components of the live, attenuated influenza vaccine (LAIV) encode the HA and NA gene segments from a circulating virus strain and the remaining gene segments from the cold-adapted ... Yan J, Morrow MP, Chu JS, Racine T, et al. Broad cross-protective anti-hemagglutination responses elicited by influenza microconsensus DNA vaccine. Vaccine 2017 Oct 31. Abstract
submitted by kickingbird at Nov, 6, 2017 from Vaccine 2017 Oct 31 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29100705/)
Despite the routine development and distribution of seasonal influenza vaccines, influenza remains an important pathogen contributing to significant human morbidity as well as mortality each year. The ... Qi W, Jia W, Liu D, Li J, et al. Emergence and adaptation of a novel highly pathogenic H7N9 influenza virus in birds and humans from a 2013-human-infecting low pathogenic ancestor. J Virol 2017 Oct 25. Abstract
submitted by kickingbird at Nov, 6, 2017 from J Virol 2017 Oct 25 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29070694/)
Since its emergence in 2013, the H7N9 low pathogenic avian influenza virus (LPAIV) has been circulating in domestic poultry in China, causing five waves of human infections. Recently, a novel H7N9 highly ... Waring BM, Sjaastad LE, Fiege JK, Fay EJ, et al. microRNA-based attenuation of influenza virus across susceptible hosts. J Virol 2017 Nov 1. Abstract
submitted by kickingbird at Nov, 6, 2017 from J Virol 2017 Nov 1 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29093096/)
Influenza A virus drives significant morbidity and mortality in humans and livestock. Annual circulation of the virus in livestock and waterfowl contributes to severe economic disruption and increases ... Kirchenbaum GA, Allen JD, Layman TS, Sautto GA, et. Infection of Ferrets with Influenza Virus Elicits a Light Chain-Biased Antibody Response against Hemagglutinin. J Immunol 2017 Oct 27. Abstract
submitted by kickingbird at Nov, 6, 2017 from J Immunol 2017 Oct 27 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29079697/)
The domestic ferret (Mustela putorius furo) is a commonly used animal model for the study of influenza virus infection and vaccination. Recently, our group has developed murine mAbs with specificity for ... Gomaa MR, Kandeil A, El-Shesheny R, Shehata MM, et. Evidence of infection with avian, human, and swine influenza viruses in pigs in Cairo, Egypt. Arch Virol 2017 Oct 26. Abstract
submitted by kickingbird at Nov, 6, 2017 from Arch Virol 2017 Oct 26 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29075888/)
The majority of the Egyptian swine population was culled in the aftermath of the 2009 H1N1 pandemic, but small-scale growing remains. We sampled pigs from piggeries and an abattoir in Cairo. We found virological ... Moasser E, Behzadian F, Moattari A, Fotouhi F, et. Characterization of the neuraminidase genes from human influenza A viruses circulating in Iran from 2010 to 2015. Arch Virol 2017 Oct 31. Abstract
submitted by kickingbird at Nov, 6, 2017 from Arch Virol 2017 Oct 31 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29086107/)
BACKGROUND: Characterization of influenza viruses is critical for detection of new emerging variants. Herein, we analyzed the genetic diversity and drug susceptibility of the neuraminidase gene (NAs) ... Yu Z, Cheng K, Sun W, Zhang X, et al. PB2 and HA mutations increase the virulence of highly pathogenic H5N5 clade 2.3.4.4 avian influenza virus in mice. Arch Virol 2017 Oct 31. Abstract
submitted by kickingbird at Nov, 6, 2017 from Arch Virol 2017 Oct 31 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29090366/)
H5 clade 2.3.4.4 influenza A viruses pose a potential threat to public health and are a cause of public concern. Here, we generated mouse-adapted viruses of a waterfowl-origin H5N5 virus (H5 clade 2.3.4.4) ... Sarvestani ST, McAuley JL. The role of the NLRP3 inflammasome in regulation of antiviral responses to influenza A virus infection. Antiviral Res 2017 Oct 30. Abstract
submitted by kickingbird at Nov, 6, 2017 from Antiviral Res 2017 Oct 30 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29097227/)
The innate immune system provides the host with both a dynamic barrier to prevent infection and a means to which rapid anti-microbial responses can be mounted. The inflammasome pathway is a critical host ... Marathe BM, Mostafa HH, Vogel P, Pascua PNQ, et al. A pharmacologically immunosuppressed mouse model for assessing influenza B virus pathogenicity and oseltamivir treatment. Antiviral Res 2017 Oct 31. Abstract
submitted by kickingbird at Nov, 6, 2017 from Antiviral Res 2017 Oct 31 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29100887/)
Immunocompromised patients are highly susceptible to influenza virus infections. Although neuraminidase inhibitor (NAI) therapy has proved effective in these patients, the treatment regimens require optimization, ... 8128 items, 20/Page, Page[257/407][|<<] [|<] [251] [252] [253] [254] [255] [256] [257] [258] [259] [260] [>|] [>>|] |
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