Wu H, Yang F, Xiao Y, Liu F, Yao H, Wu N. Adaptive amino acid substitutions enhance the virulence of an avian-origin H6N1 influenza virus in mice. Infect Genet Evol. 2019 Jun 11:103918. Abstract
submitted by kickingbird at Jun, 16, 2019 from Infect Genet Evol. 2019 Jun 11:103918 (via https://www.sciencedirect.com/science/article/pii/S156713481)
The H6N1 subtype avian influenza virus (AIV) is a zoonotic infectious disease pathogen, which poses a threat to human health. In order to study the possible substitution of H6N1 AIV for mammals, an avian-origin ... Yang L, et al. Emergence of waterfowl-originated gene cassettes in HPAI H7N9 viruses caused severe human infection in Fujian, China. Influenza Other Respir Viruses. 2019 Jun 11. Abstract
submitted by kickingbird at Jun, 14, 2019 from Influenza Other Respir Viruses. 2019 Jun 11 (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12657)
BACKGROUND: Highly pathogenic avian influenza (HPAI) A(H7N9) virus emerged and caused human infections during the 2016-2017 epidemic wave of influenza A(H7N9) viruses in China. We report a human infection ... Hodges EN, et al. Detection of oseltamivir-resistant zoonotic and animal influenza A viruses using the rapid influenza antiviral resistance test. Influenza Other Respir Viruses. 2019 Jun 11.. Abstract
submitted by kickingbird at Jun, 14, 2019 from Influenza Other Respir Viruses. 2019 Jun 11. (via https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12661)
Mutations in the influenza virus neuraminidase (NA) that cause reduced susceptibility to the NA inhibitor (NAI) oseltamivir may occur naturally or following antiviral treatment. Currently, detection uses ... Thomaston JL, Wu Y, Polizzi N, Liu L, et al. X-ray crystal structure of the influenza A M2 proton channel S31N mutant in two conformational states: an open and shut case. J Am Chem Soc. 2019 Jun 11.. Abstract
submitted by kickingbird at Jun, 14, 2019 from J Am Chem Soc. 2019 Jun 11. (via https://pubs.acs.org/doi/10.1021/jacs.9b02196)
The amantadine-resistant S31N mutant of the influenza A M2 proton channel has become prevalent in currently circulating viruses. Here we have solved an X-ray crystal structure of M2(22-46) S31N that contains ... Loth L, Pham LT, Stevenson MA. Spatio-temporal distribution of outbreaks of highly pathogenic avian influenza virus subtype H5N1 in Vietnam, 2015~2018. Transbound Emerg Dis. 2019 Jun 10.. Abstract
submitted by kickingbird at Jun, 13, 2019 from Transbound Emerg Dis. 2019 Jun 10. (via https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13259)
Despite strong commitments of the central and provincial veterinary authorities in Vietnam to control highly pathogenic avian influenza H5N1 (HPAI-H5N1) in poultry and to diminish the risk of human infection, ... Qiang X, Kou Z. Scoring amino acid mutation to predict pandemic risk of avian influenza virus. BMC Bioinformatics. 2019 Jun 10. Abstract
submitted by kickingbird at Jun, 13, 2019 from BMC Bioinformatics. 2019 Jun 10 (via https://bmcbioinformatics.biomedcentral.com/articles/10.1186)
BACKGROUND: Avian influenza virus can directly cross species barriers and infect humans with high fatality. As antigen novelty for human host, the public health is being challenged seriously. The pandemic ... Du W, et al. The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance. PLoS Pathog. 2019 Jun 10;15(6):e1007860. Abstract
submitted by kickingbird at Jun, 13, 2019 from PLoS Pathog. 2019 Jun 10;15(6):e1007860 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A virus (IAV) neuraminidase (NA) receptor-destroying activity and hemagglutinin (HA) receptor-binding affinity need to be balanced with the host receptor repertoire for optimal viral fitness. ... Eladl AH, Alzayat AA, Ali HS, Fahmy HA, Ellakany H. Comparative molecular characterization, pathogenicity and seroprevalence of avian influenza virus H9N2 in commercial and backyard poultry flocks. Comp Immunol Microbiol Infect Dis. 2019 Jun;64:81-. Abstract
submitted by kickingbird at Jun, 11, 2019 from Comp Immunol Microbiol Infect Dis. 2019 Jun;64:81- (via https://www.sciencedirect.com/science/article/pii/S014795711)
This study was conducted to perform the comparative molecular characterization of avian influenza virus (AIV) H9N2, pathogenicity and seroprevalence in commercial and backyard poultry flocks. Fifty commercial ... Musharrafieh R, et al. The L46P mutant confers a novel allosteric mechanism of resistance towards the influenza A virus M2 S31N proton channel blockers. Mol Pharmacol. 2019 Jun 7. Abstract
submitted by kickingbird at Jun, 11, 2019 from Mol Pharmacol. 2019 Jun 7 (via http://molpharm.aspetjournals.org/content/early/2019/06/07/m)
The FDA-approved influenza A antiviral amantadine inhibits the wild-type (WT) AM2 channel but not the S31N mutant predominantly found in circulating strains. In this study, serial viral passages were applied ... Yang G, et al. Detection of highly pathogenic avian influenza A(H5N6) viruses in waterfowl in Bangladesh. Virology. 2019 May 28;534:36-44. Abstract
submitted by kickingbird at Jun, 11, 2019 from Virology. 2019 May 28;534:36-44 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Bangladesh has reported repeated outbreaks of highly pathogenic avian influenza (HPAI) A(H5) viruses in poultry since 2007. Because of the large number of live poultry markets (LPM) relative to the population ... Jia R, et al. Design, synthesis and biological evaluation of "Multi-Site"-binding influenza virus neuraminidase. Eur J Med Chem. 2019 May 30;178:64-80. Abstract
submitted by kickingbird at Jun, 11, 2019 from Eur J Med Chem. 2019 May 30;178:64-80 (via https://www.sciencedirect.com/science/article/pii/S022352341)
Encouraged by our earlier discovery of neuraminidase inhibitors targeting 150-cavity or 430-cavity, herein, to yield more potent inhibitors, we designed, synthesized, and biologically evaluated a series ... Wang C, et al. Infection of chicken H9N2 influenza viruses in different species of domestic ducks. Vet Microbiol. 2019 Jun;233:1-4.. Abstract
submitted by kickingbird at Jun, 11, 2019 from Vet Microbiol. 2019 Jun;233:1-4. (via https://www.sciencedirect.com/science/article/pii/S037811351)
Domestic ducks are considered as the interface between wild aquatic birds and terrestrial poultry and play an important role in the transmission and evolution of avian influenza viruses (AIVs). However, ... Artarini A, et al. Regulation of influenza a virus mRNA splicing by CLK1. Antiviral Res. 2019 Jun 6. Abstract
submitted by kickingbird at Jun, 11, 2019 from Antiviral Res. 2019 Jun 6 (via https://www.sciencedirect.com/science/article/pii/S016635421)
Influenza A virus carries eight negative single-stranded RNAs and uses spliced mRNAs to increase the number of proteins produced from them. Several genome-wide screens for essential host factors for influenza ... Bergmann S, Elbahesh H. Targeting the proviral host kinase, FAK, limits influenza a virus pathogenesis and NFkB-regulated pro-inflammatory responses. Virology. 2019 Jun 1;534:54-63.. Abstract
submitted by kickingbird at Jun, 11, 2019 from Virology. 2019 Jun 1;534:54-63. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza A virus (IAV) infections result in ～500,000 global deaths annually. Host kinases link multiple signaling pathways at various stages of infection and are attractive therapeutic target. Focal adhesion ... Yuan B, et al. The tree shrew is a promising model for the study of influenza B virus infection. Virol J. 2019 Jun 7;16(1):77. Abstract
submitted by kickingbird at Jun, 10, 2019 from Virol J. 2019 Jun 7;16(1):77 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
BACKGROUND: Influenza B virus is a main causative pathogen of annual influenza epidemics, however, research on influenza B virus in general lags behind that on influenza A viruses, one of the important ... Ghafouri SA, et al. Full genome characterization of Iranian H5N8 highly pathogenic avian influenza virus from Hooded Crow (Corvus cornix), 2017: The first report. Comp Immunol Microbiol Infect Dis. 2019 Jun;64:73-. Abstract
submitted by kickingbird at Jun, 10, 2019 from Comp Immunol Microbiol Infect Dis. 2019 Jun;64:73- (via https://www.sciencedirect.com/science/article/pii/S014795711)
During 2014-2017 Clade 2.3.4.4 H5N8 highly pathogenic avian influenza viruses (HPAIVs) have spread worldwide. In 2016, an epidemic of HPAIV H5N8 in Iran caused mass deaths among wild birds, and several ... Kouba T, Drncová P, Cusack S. Structural snapshots of actively transcribing influenza polymerase. Nat Struct Mol Biol. 2019 Jun;26(6):460-470. Abstract
submitted by kickingbird at Jun, 9, 2019 from Nat Struct Mol Biol. 2019 Jun;26(6):460-470 (via https://www.nature.com/articles/s41594-019-0232-z)
Influenza virus RNA-dependent RNA polymerase uses unique mechanisms to transcribe its single-stranded genomic viral RNA (vRNA) into messenger RNA. The polymerase is initially bound to a promoter comprising ... Ng S, et al. Novel correlates of protection against pandemic H1N1 influenza A virus infection. Nat Med. 2019 Jun 3.. Abstract
submitted by kickingbird at Jun, 9, 2019 from Nat Med. 2019 Jun 3. (via https://www.nature.com/articles/s41591-019-0463-x)
Influenza viruses remain a severe threat to human health, causing up to 650,000 deaths annually1,2. Seasonal influenza virus vaccines can prevent infection, but are rendered ineffective by antigenic drift. ... Park SC, et al. Pathogenicity of clade 2.3.4.4 H5N6 highly pathogenic avian influenza virus in three chicken breeds from South Korea in 2016/2017. J Vet Sci. 2019 May;20(3):e27. Abstract
submitted by kickingbird at Jun, 9, 2019 from J Vet Sci. 2019 May;20(3):e27 (via https://synapse.koreamed.org/DOIx.php?id=10.4142/jvs.2019.20)
In 2016, novel H5N6 highly pathogenic avian influenza virus emerged in Korea. During the outbreak, the virus caused the largest culling, especially in brown chicken lines. We determined the pathogenicity ... Kim JI, et al. Novel small molecule targeting the hemagglutinin stalk of influenza viruses. J Virol. 2019 Jun 5.. Abstract
submitted by kickingbird at Jun, 9, 2019 from J Virol. 2019 Jun 5. (via https://jvi.asm.org/content/early/2019/05/30/JVI.00878-19)
Combating influenza is one of the perennial global public health issues to be managed. Antiviral drugs are useful for the treatment of influenza in the absence of an appropriate vaccine. However, the appearance ... 8128 items, 20/Page, Page[182/407][|<<] [|<] [181] [182] [183] [184] [185] [186] [187] [188] [189] [190] [>|] [>>|] |
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