Patel MC, Chesnokov A, Jones J, Mishin VP, De La C. Susceptibility of widely diverse influenza a viruses to PB2 polymerase inhibitor pimodivir. Antiviral Res. 2021 Feb 10:105035. Abstract
submitted by kickingbird at Feb, 15, 2021 from Antiviral Res. 2021 Feb 10:105035 (via https://www.sciencedirect.com/science/article/pii/S016635422)
Pimodivir exerts an antiviral effect on the early stages of influenza A virus replication by inhibiting the cap-binding function of polymerase basic protein 2 (PB2). In this study, we used a combination ... Sch?n J, Ran W, Gorka M, Schwemmle M, Beer M, Hoff. A modified live bat influenza A virus-based vaccine prototype provides full protection against HPAIV H5N1. NPJ Vaccines. 2020 May 15;5(1):40. Abstract
submitted by kickingbird at Feb, 14, 2021 from NPJ Vaccines. 2020 May 15;5(1):40 (via https://www.nature.com/articles/s41541-020-0185-6)
Highly pathogenic avian influenza viruses (HPAIVs) of subtype H5 are a major threat for poultry holdings worldwide, here especially the zoonotic Asian H5N1 viruses. These HPAIVs have caused more than 500 ... Pleguezuelos O, James E, Fernandez A, Lopes V, Ros. Efficacy of FLU-v, a broad-spectrum influenza vaccine, in a randomized phase IIb human influenza challenge study. NPJ Vaccines. 2020 Mar 13;5(1):22. Abstract
submitted by kickingbird at Feb, 14, 2021 from NPJ Vaccines. 2020 Mar 13;5(1):22
FLU-v, developed by PepTcell (SEEK), is a peptide vaccine aiming to provide a broadly protective cellular immune response against influenza A and B. A randomized, double-blind, placebo-controlled, single-center, ... de Jonge J, van Dijken H, de Heij F, Spijkers S, M. H7N9 influenza split vaccine with SWE oil-in-water adjuvant greatly enhances cross-reactive humoral immunity and protection against severe pneumonia in ferrets. NPJ Vaccines. 2020 May 11;5(1):38.. Abstract
submitted by kickingbird at Feb, 14, 2021 from NPJ Vaccines. 2020 May 11;5(1):38. (via https://www.nature.com/articles/s41541-020-0187-4)
Until universal influenza vaccines become available, pandemic preparedness should include developing classical vaccines against potential pandemic influenza subtypes. We here show that addition of SWE ... Kim WH, Bae SH, Cho S. Spatiotemporal Dynamics of Highly Pathogenic Avian Influenza Subtype H5N8 in Poultry Farms, South Korea. Viruses. 2021 Feb 10;13(2):274. Abstract
submitted by kickingbird at Feb, 14, 2021 from Viruses. 2021 Feb 10;13(2):274 (via https://www.mdpi.com/1999-4915/13/2/274)
Highly pathogenic avian influenza (HPAI), a zoonotic disease, is a major threat to humans and poultry health worldwide. In January 2014, HPAI virus subtype H5N8 first infected poultry farms in South Korea, ... Tsuneki-Tokunaga A, Kanai K, Itagaki A, Tsuchie H,. Growth capability of epidemic influenza viruses in Japan since the 2009 H1N1 pandemic. Arch Virol. 2021 Feb 12. Abstract
submitted by kickingbird at Feb, 14, 2021 from Arch Virol. 2021 Feb 12 (via https://link.springer.com/article/10.1007/s00705-021-04976-5)
AbstractThe correlation of viral growth capability (n = 156) with the viral load in nasopharyngeal swabs (n = 76) was assessed. Epidemic influenza A/H1N1, A/H3N2, and B viruses showed a wide range of growth ... Li B, Xiang G, He J, Li H, Xu C, Yu A, Zhao Z, Wan. H7N9 influenza virus surveillance in Gansu, China in 2017. Virus Res. 2021 Feb 9:198335. Abstract
submitted by kickingbird at Feb, 14, 2021 from Virus Res. 2021 Feb 9:198335 (via https://www.sciencedirect.com/science/article/abs/pii/S01681)
Avian H7N9 influenza virus, which emerged in 2013 China, had caused the fifth wave of peaks in 2016-2017. Gansu Province locate in western China far away from the epicenter of the virus, also detected ... Hidekazu Osada, Chon I, Phyu WW, Wagatsuma K, Naga. Development of cycling probe based real-time PCR methodology for influenza A viruses possessing the PA/I38T amino acid substitution associated with reduced baloxavir susceptibility. Antiviral Res. 2021 Feb 9:105036. Abstract
submitted by kickingbird at Feb, 14, 2021 from Antiviral Res. 2021 Feb 9:105036 (via https://www.sciencedirect.com/science/article/abs/pii/S01663)
Baloxavir marboxil has been used for influenza treatment since March 2018 in Japan. After baloxavir treatment, the most frequently detected substitution is Ile38Thr in polymerase acidic protein (PA/I38T), ... Ashraf U, Benoit-Pilven C, Navratil V, Ligneau C,. Influenza virus infection induces widespread alterations of host cell splicing. NAR Genom Bioinform. 2020 Nov 21;2(4):lqaa095. Abstract
submitted by kickingbird at Feb, 13, 2021 from NAR Genom Bioinform. 2020 Nov 21;2(4):lqaa095 (via https://academic.oup.com/nargab/article/2/4/lqaa095/5998301)
Influenza A viruses (IAVs) use diverse mechanisms to interfere with cellular gene expression. Although many RNA-seq studies have documented IAV-induced changes in host mRNA abundance, few were designed ... Usui T, Ueda M, Azumano A, Nomura M, Arima T, Mura. A cluster epidemic of influenza A(H1N1)pdm09 virus infection in four captive cheetahs (Acinonyx jubatus). Zoonoses Public Health. 2021 Feb 11. Abstract
submitted by kickingbird at Feb, 13, 2021 from Zoonoses Public Health. 2021 Feb 11 (via https://pubmed.ncbi.nlm.nih.gov/33576190/)
In January 2019, four cheetahs (Acinonyx jubatus) kept at a Japanese zoo intermittently showed respiratory signs following the incidence of seasonal influenza in animal caregivers. Respiratory materials ... Zeng Y, Xu S, Wei Y, Zhang X, Wang Q, Jia Y, Wang. The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation. PLoS Pathog. 2021 Feb 12;17(2):e1009300. Abstract
submitted by kickingbird at Feb, 13, 2021 from PLoS Pathog. 2021 Feb 12;17(2):e1009300 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Influenza A virus (IAV) has evolved various strategies to counteract the innate immune response using different viral proteins. However, the mechanism is not fully elucidated. In this study, we identified ... Almatrrouk S, Saba I, Abozaid S, Al-Qahtani AA, Al. Virus sensing receptors in cellular infectivity of influenza A virus. J Infect Dev Ctries. 2021 Jan 31;15(1):1-8. Abstract
submitted by kickingbird at Feb, 12, 2021 from J Infect Dev Ctries. 2021 Jan 31;15(1):1-8 (via https://www.jidc.org/index.php/journal/article/view/13258)
An innate immune response is essential to mobilize protective immunity upon the infection of respiratory epithelial cells with influenza A virus (IAV). The response is classified as early (nonspecific ... Lopez Moreno G, Nirmala J, Goodell C, Culhane M, T. Shedding and transmission of a live attenuated influenza A virus vaccine in pre-weaned pigs under field conditions. PLoS One. 2021 Feb 11;16(2):e0246690. Abstract
submitted by kickingbird at Feb, 12, 2021 from PLoS One. 2021 Feb 11;16(2):e0246690 (via https://pubmed.ncbi.nlm.nih.gov/33571263/)
Influenza A virus (IAV) is one of the most important respiratory viruses affecting pig health and vaccination is the most common strategy to control influenza infections. In this field study we assessed ... Li J, Liang L, Jiang L, Wang Q, Wen X, Zhao Y, Cui. Viral RNA-binding ability conferred by SUMOylation at PB1 K612 of influenza A virus is essential for viral pathogenesis and transmission. PLoS Pathog. 2021 Feb 11;17(2):e1009336. Abstract
submitted by kickingbird at Feb, 12, 2021 from PLoS Pathog. 2021 Feb 11;17(2):e1009336 (via https://pubmed.ncbi.nlm.nih.gov/33571308/)
Posttranslational modifications, such as SUMOylation, play specific roles in the life cycle of invading pathogens. However, the effect of SUMOylation on the adaptation, pathogenesis, and transmission of ... Byrne AMP, Reid SM, Seekings AH, Nú?ez A, Obeso Pr. H7N7 Avian Influenza Virus Mutation from Low to High Pathogenicity on a Layer Chicken Farm in the UK. Viruses. 2021 Feb 8;13(2):259. Abstract
submitted by kickingbird at Feb, 11, 2021 from Viruses. 2021 Feb 8;13(2):259 (via https://www.mdpi.com/1999-4915/13/2/259)
Avian influenza virus (AIV) subtypes H5 and H7 are capable of mutating from low to high pathogenicity strains, causing high mortality in poultry with significant economic losses globally. During 2015, ... Venkatramanan S, Sadilek A, Fadikar A, Barrett CL,. Forecasting influenza activity using machine-learned mobility map. Nat Commun. 2021 Feb 9;12(1):726. Abstract
submitted by kickingbird at Feb, 11, 2021 from Nat Commun. 2021 Feb 9;12(1):726 (via https://www.nature.com/articles/s41467-021-21018-5)
Human mobility is a primary driver of infectious disease spread. However, existing data is limited in availability, coverage, granularity, and timeliness. Data-driven forecasts of disease dynamics are ... Kong H, Burke DF, da Silva Lopes TJ, Takada K, Ima. Plasticity of the Influenza Virus H5 HA Protein. mBio. 2021 Feb 9;12(1):e03324-20. Abstract
submitted by kickingbird at Feb, 11, 2021 from mBio. 2021 Feb 9;12(1):e03324-20 (via https://mbio.asm.org/content/12/1/e03324-20)
Since the emergence of highly pathogenic avian influenza viruses of the H5 subtype, the major viral antigen, hemagglutinin (HA), has undergone constant evolution, resulting in numerous genetic and antigenic ... Zhang X, Li Y, Jin S, Wang T, Sun W, Zhang Y, Li F. H9N2 influenza virus spillover into wild birds from poultry in China bind to human-type receptors and transmit in mammals via respiratory droplets. Transbound Emerg Dis. 2021 Feb 10. Abstract
submitted by kickingbird at Feb, 11, 2021 from Transbound Emerg Dis. 2021 Feb 10 (via https://pubmed.ncbi.nlm.nih.gov/33566453/)
H9N2 influenza virus has been reported worldwide for several decades, and it has evolved into multiple genotypes among domestic poultry. However, the study involving ecology and evolution of low pathogenic ... Sangkakam A, Hemachudha P, Saraya AW, Thaweethee-S. Detection of influenza virus in rectal swabs of patients admitted in hospital for febrile illnesses in Thailand. SAGE Open Med. 2021 Jan 22;9:2050312121989631. Abstract
submitted by kickingbird at Feb, 10, 2021 from SAGE Open Med. 2021 Jan 22;9:2050312121989631 (via https://journals.sagepub.com/doi/10.1177/2050312121989631)
Introduction: Influenza virus favours the respiratory tract as its primary site of host entry and replication, and it is transmitted mainly via respiratory secretions. Nasopharyngeal swab is the gold standard ... De Conto F, Conversano F, Razin SV, Belletti S, Ar. Host-cell dependent role of phosphorylated keratin 8 during influenza A/NWS/33 virus (H1N1) infection in mammalian cells. Virus Res. 2021 Feb 5:198333. Abstract
submitted by kickingbird at Feb, 10, 2021 from Virus Res. 2021 Feb 5:198333 (via https://www.sciencedirect.com/science/article/abs/pii/S01681)
In this study, we investigated the involvement of keratin 8 during human influenza A/NWS/33 virus (H1N1) infection in semi-permissive rhesus monkey-kidney (LLC-MK2) and permissive human type II alveolar ... 8128 items, 20/Page, Page[130/407][|<<] [|<] [121] [122] [123] [124] [125] [126] [127] [128] [129] [130] [>|] [>>|] |
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