Maida CM, Mazzucco W, Priano W, Palermo R, Grazian. Detection of influenza virus in urban wastewater during the season 2022/2023 in Sicily, Italy. Front Public Health. 2024 Jul 23;12:1383536. Abstract submitted by kickingbird at Aug, 8, 2024 from Front Public Health. 2024 Jul 23;12:1383536 (via https://www.frontiersin.org/journals/public-health/articles/) Introduction: Seasonal influenza generally represents an underestimated public health problem with significant socioeconomic implications. Monitoring and detecting influenza epidemics are important tasks ... Hew YL, Hiono T, Monne I, Nabeshima K, Sakuma S, K. Cocirculation of Genetically Distinct Highly Pathogenic Avian Influenza H5N5 and H5N1 Viruses in Crows, Hokkaido, Japan. Emerg Infect Dis. 2024 Aug 6;30(9). Abstract submitted by kickingbird at Aug, 7, 2024 from Emerg Infect Dis. 2024 Aug 6;30(9) (via https://wwwnc.cdc.gov/eid/article/30/9/24-0356_article) We isolated highly pathogenic avian influenza (HPAI) H5N5 and H5N1 viruses from crows in Hokkaido, Japan, during winter 2023-24. They shared genetic similarity with HPAI H5N5 viruses from northern Europe ... Liu L, Wang F, Wu Y, Mi W, Zhang Y, Chen L, Wang D. The V223I substitution in hemagglutinin reduces the binding affinity to human-type receptors while enhancing the thermal stability of the H3N2 canine influenza virus. Front Microbiol. 2024 Jul 22;15:1442163. Abstract submitted by kickingbird at Aug, 7, 2024 from Front Microbiol. 2024 Jul 22;15:1442163 (via https://www.frontiersin.org/journals/microbiology/articles/1) Given the intimate relationship between humans and dogs, the H3N2 canine influenza viruses (CIVs) pose a threat to public health. In our study, we isolated four H3N2 CIVs from 3,758 dog nasal swabs in ... Cui X, Vervaeke P, Gao Y, Opsomer L, Sun Q, Snoeck. Immunogenicity and biodistribution of lipid nanoparticle formulated self-amplifying mRNA vaccines against H5 avian influenza. NPJ Vaccines. 2024 Aug 3;9(1):138. Abstract submitted by kickingbird at Aug, 6, 2024 from NPJ Vaccines. 2024 Aug 3;9(1):138 (via https://www.nature.com/articles/s41541-024-00932-x) This study reports on the immunogenicity and biodistribution of H5 hemagglutinin (HA)-based self-amplifying (sa) mRNA vaccines in mice. Four sa-mRNA vaccines encoding either a secreted full-length HA, ... Liu DJ, Zhong XQ, Ru YX, Zhao SL, Liu CC, Tang YB,. Disulfide-stabilized Trimeric Hemagglutinin Ectodomains Provide Enhanced Heterologous Influenza Protection. Emerg Microbes Infect. 2024 Aug 5:2389095. Abstract submitted by kickingbird at Aug, 6, 2024 from Emerg Microbes Infect. 2024 Aug 5:2389095 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2) Influenza virus infection poses a continual menace to public health. Here, we developed soluble trimeric HA ectodomain vaccines by establishing interprotomer disulfide bonds in the stem region, which effectively ... Chen SS, Yang YL, Wang HY, Guo TK, Azeem RM, Shi C. CRISPR/Cas13a-based genome editing for establishing the detection method of H9N2 subtype avian influenza virus. Poult Sci. 2024 Jul 9;103(10):104068. Abstract submitted by kickingbird at Aug, 5, 2024 from Poult Sci. 2024 Jul 9;103(10):104068 (via https://www.sciencedirect.com/science/article/pii/S003257912) Avian influenza virus (AIV) subtype H9N2 has significantly threatened the poultry business in recent years by having become the predominant subtype in flocks of chickens, ducks, and pigeons. In addition, ... Cargnin Faccin F, Cáceres CJ, Gay LC, Seibert B, v. Mass vaccination with reassortment-impaired live H9N2 avian influenza vaccine. NPJ Vaccines. 2024 Aug 3;9(1):136. Abstract submitted by kickingbird at Aug, 5, 2024 from NPJ Vaccines. 2024 Aug 3;9(1):136 (via https://www.nature.com/articles/s41541-024-00923-y) Avian influenza poses a severe threat to poultry production and global food security, prompting the development of vaccination programs in numerous countries. Modified live virus (MLV) vaccines, with their ... Jefferson J.S. Santos, etc.,al. [preprint]Bovine H5N1 influenza virus binds poorly to human-type sialic acid receptors. https://doi.org/10.1101/2024.08.01.606177. Abstract submitted by kickingbird at Aug, 5, 2024 from https://doi.org/10.1101/2024.08.01.606177 (via https://www.biorxiv.org/content/10.1101/2024.08.01.606177v1) Clade 2.3.4.4b highly pathogenic H5N1 avian influenza (HPAI) viruses started circulating widely in lactating dairy cattle in the United States at the end of 2023. Avian influenza viruses enter cells after ... Bhattacharya A, Bagheri N, Boxer SG. A Fluorogenic Pseudoinfection Assay to Probe Transfer and Distribution of Influenza Viral Contents to Target Vesicles. Anal Chem. 2024 Jul 31. Abstract submitted by kickingbird at Aug, 3, 2024 from Anal Chem. 2024 Jul 31 (via https://pubs.acs.org/doi/10.1021/acs.analchem.4c01142) Fusion of enveloped viruses with endosomal membranes and subsequent release of the viral genome into the cytoplasm are crucial to the viral infection cycle. It is often modeled by performing fusion between ... Cao L, She Z, Zhao Y, Cheng C, Li Y, Xu T, Mao H,. Inhibition of RAN Attenuates Influenza A Virus Replication and Nucleoprotein Nuclear Export. Emerg Microbes Infect. 2024 Aug 1:2387910. Abstract submitted by kickingbird at Aug, 3, 2024 from Emerg Microbes Infect. 2024 Aug 1:2387910 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2) Nuclear export of the viral ribonucleoprotein (vRNP) is a critical step in the influenza A virus (IAV) life cycle and may be an effective target for the development of anti- IAV drugs. The host factor ... Kwon T, Artiaga BL, McDowell CD, Whitworth KM, Wel. Gene editing of pigs to control influenza A virus infections. Emerg Microbes Infect. 2024 Jul 31:2387449. Abstract submitted by kickingbird at Aug, 2, 2024 from Emerg Microbes Infect. 2024 Jul 31:2387449 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2) Proteolytic activation of the hemagglutinin (HA) glycoprotein by host cellular proteases is pivotal for influenza A virus (IAV) infectivity. Highly pathogenic avian influenza viruses possess the multibasic ... Ismaila Shittu, etc.,al. [preprint]A One Health Investigation into H5N1 Avian Influenza Virus Epizootics on Two Dairy Farms. https://doi.org/10.1101/2024.07.27.24310982. Abstract submitted by kickingbird at Aug, 1, 2024 from https://doi.org/10.1101/2024.07.27.24310982 (via https://www.medrxiv.org/content/10.1101/2024.07.27.24310982v) Background: In early April 2024 we studied two Texas dairy farms which had suffered incursions of H5N1 highly pathogenic avian influenza virus (HPAIV) the previous month. Methods: We employed molecular ... Li X, Xie Z, Wei Y, Li M, Zhang M, Luo S, Xie L. Recombinant Hemagglutinin Protein from H9N2 Avian Influenza Virus Exerts Good Immune Effects in Mice. Microorganisms. 2024; 12(8):1552. Abstract submitted by kickingbird at Jul, 30, 2024 from Microorganisms. 2024; 12(8):1552 (via https://www.mdpi.com/2076-2607/12/8/1552) The H9N2 subtype of avian influenza virus (AIV) causes enormous economic losses and poses a significant threat to public health; the development of vaccines against avian influenza is ongoing. To study ... Tamiru Alkie, etc.,al. [preprint]Effectiveness of Pasteurization for the Inactivation of H5N1 Influenza Virus in Raw Whole Milk. https://doi.org/10.1101/2024.07.23.24310825. Abstract submitted by kickingbird at Jul, 30, 2024 from https://doi.org/10.1101/2024.07.23.24310825 (via https://www.medrxiv.org/content/10.1101/2024.07.23.24310825v) Highly pathogenic avian influenza (HPAI) clade 2.3.4.4b H5Nx viruses continue to cause episodic incursions and have been detected in more than 12 taxonomic orders encompassing more than 80 avian species, ... Madeline Yunker, etc.,al. Genomic Evolution of Influenza During the 2023-2024 Season, the Johns Hopkins Health System. Journal of Clinical Virology, 2024. Abstract submitted by kickingbird at Jul, 29, 2024 from Journal of Clinical Virology, 2024 (via https://www.sciencedirect.com/science/article/pii/S138665322) Influenza, a human disease caused by viruses in the Orthomyxoviridae family, is estimated to infect 5%-10% of adults and 20%-30% of children annually. Influenza A (IAV) and Influenza B (IBV) viruses accumulate ... Vendruscolo FE, Pissetti C, de Freitas Costa E, Za. Evaluation of nasal swab and nasal wipe for detection of Influenza A in swine using Bayesian latent class analysis. Prev Vet Med. 2024 Jul 17;230:106292. Abstract submitted by kickingbird at Jul, 29, 2024 from Prev Vet Med. 2024 Jul 17;230:106292 (via https://www.sciencedirect.com/science/article/abs/pii/S01675) Influenza A virus (IAV) is an important pathogen in Brazilian swine herds, and monitoring the viral circulation is essential to control and reduce the transmission. Surveillance programs for IAV are often ... McMenamy MJ, McKenna R, Bailie VB, Cunningham B, J. Evaluating the Impact of Low-Pathogenicity Avian Influenza H6N1 Outbreaks in United Kingdom and Republic of Ireland Poultry Farms during 2020. Viruses. 2024 Jul 16;16(7):1147. Abstract submitted by kickingbird at Jul, 28, 2024 from Viruses. 2024 Jul 16;16(7):1147 (via https://www.mdpi.com/1999-4915/16/7/1147) In January 2020, increased mortality was reported in a small broiler breeder flock in County Fermanagh, Northern Ireland. Gross pathological findings included coelomitis, oophoritis, salpingitis, visceral ... Montano Valle DLN, Berezowski J, Delgado-Hernández. Modeling transmission of avian influenza viruses at the human-animal-environment interface in Cuba. Front Vet Sci. 2024 Jul 11;11:1415559. Abstract submitted by kickingbird at Jul, 27, 2024 from Front Vet Sci. 2024 Jul 11;11:1415559 (via https://www.frontiersin.org/journals/veterinary-science/arti) Introduction: The increasing geographical spread of highly pathogenic avian influenza viruses (HPAIVs) is of global concern due to the underlying zoonotic and pandemic potential of the virus and its economic ... de Vos CJ, Elbers ARW. Quantitative Risk Assessment of Wind-Supported Transmission of Highly Pathogenic Avian Influenza Virus to Dutch Poultry Farms via Fecal Particles from Infected Wild Birds in the Environment. Pathogens. 2024 Jul 8;13(7):571. Abstract submitted by kickingbird at Jul, 27, 2024 from Pathogens. 2024 Jul 8;13(7):571 (via https://www.mdpi.com/2076-0817/13/7/571) A quantitative microbial risk assessment model was developed to estimate the probability that the aerosolization of fecal droppings from wild birds in the vicinity of poultry farms would result in the ... Gautier Richard, etc.,al. [preprint]Major change in swine influenza virus diversity in France owing to emergence and widespread dissemination of a newly introduced H1N2 1C genotype in 2020. https://doi.org/10.1101/2024.07.25.605108. Abstract submitted by kickingbird at Jul, 26, 2024 from https://doi.org/10.1101/2024.07.25.605108 (via https://www.biorxiv.org/content/10.1101/2024.07.25.605108v1) Swine influenza A viruses (swIAV) are a major cause of respiratory disease in pigs worldwide, presenting significant economic and health risks. 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