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2025-4-1 2:23:53
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Le Sage V, Werner BD, Merrbach GA, Petnuch SE, O’C. Influenza A(H5N1) Immune Response among Ferrets with Influenza A(H1N1)pdm09 Immunity. Emerg Infect Dis. 2025 Mar.  Abstract  
submitted by kickingbird at Feb, 24, 2025 from Emerg Infect Dis. 2025 Mar (via https://wwwnc.cdc.gov/eid/article/31/3/24-1485_article)
The emergence of highly pathogenic avian influenza A(H5N1) virus in dairy cattle herds across the United States in 2024 caused several human infections. Understanding the risk for spillover infections ...

Yu X, Ni Z, Wang Y, Wang J, Deng G, Shi J, Kong H,. Claudin-11 plays a pivotal role in the clathrin-mediated endocytosis of influenza A virus. Sci China Life Sci. 2025 Feb 20.  Abstract  
submitted by kickingbird at Feb, 24, 2025 from Sci China Life Sci. 2025 Feb 20 (via https://link.springer.com/article/10.1007/s11427-024-2856-y)
Identification of host factors that play a key role in viral replication is of great importance for antiviral development. Metabotropic glutamate receptor subtype 2 (mGluR2) is the receptor to trigger ...

Echeverri-De la Hoz D, Martínez-Bravo C, Gastelbon. Genomics of novel influenza A virus (H18N12) in bats, Caribe Colombia. Sci Rep. 2025 Feb 22;15(1):6507.  Abstract  
submitted by kickingbird at Feb, 24, 2025 from Sci Rep. 2025 Feb 22;15(1):6507 (via https://www.nature.com/articles/s41598-025-91026-8)
Influenza viruses are highly capable of mutating and adapting in mammalian hosts. While these viruses have been extensively studied in birds, research on their presence in bats has been limited. However, ...

Karla M Castro, etc.,al. [preprint]Structure-based Design of Chimeric Influenza Hemagglutinins to Elicit Cross-group Immunity. https://doi.org/10.1101/2024.12.17.628867.  Abstract  
submitted by kickingbird at Feb, 24, 2025 from https://doi.org/10.1101/2024.12.17.628867 (via https://www.biorxiv.org/content/10.1101/2024.12.17.628867v2)
Antigenic variability among influenza virus strains poses a significant challenge to developing broadly protective, long-lasting vaccines. Current annual vaccines target specific strains, requiring accurate ...

Garazi Pena Alzua, etc.,al. [preprint]Human monoclonal antibodies that target clade 2.3.4.4b H5N1 hemagglutinin. https://doi.org/10.1101/2025.02.21.639446.  Abstract  
submitted by kickingbird at Feb, 24, 2025 from https://doi.org/10.1101/2025.02.21.639446 (via https://www.biorxiv.org/content/10.1101/2025.02.21.639446v1)
The highly pathogenic avian influenza H5N1 virus clade 2.3.4.4b has been spreading globally since 2022, causing mortality and morbidity in domestic and wild birds and mammals, including infection in humans, ...

Oona Liedes, etc.,al. [preprint]Inactivated Zoonotic Influenza A(H5N8) Vaccine Induces Robust Antibody Responses Against Recent Highly Pathogenic Avian Influenza Clade 2.3.4.4b A(H5N1) Viruses. https://doi.org/10.1101/2025.02.12.25322044.  Abstract  
submitted by kickingbird at Feb, 22, 2025 from https://doi.org/10.1101/2025.02.12.25322044 (via https://www.medrxiv.org/content/10.1101/2025.02.12.25322044v)
In 2023, Finland faced an outbreak of highly pathogenic avian influenza caused by clade 2.3.4.4b A(H5N1) viruses, which spread from wild birds to fur farms. Vaccinations of individuals at-risk, such as ...

Gordon C. Adams, etc.,al. [preprint]Combing the haystacks: The search for highly pathogenic avian influenza virus using a combined clinical and research-developed testing strategy. https://doi.org/10.1101/2025.02.12.25321810.  Abstract  
submitted by kickingbird at Feb, 22, 2025 from https://doi.org/10.1101/2025.02.12.25321810 (via https://www.medrxiv.org/content/10.1101/2025.02.12.25321810v)
Background Highly pathogenic H5 avian influenza A has caused sporadic human infections, increasing the risk for potential human-to-human spread. In 2024, the U.S. experienced outbreaks among poultry and ...

Gonzales JE 2nd, Kim I, Bastiray A, Hwang W, Cho J. Evolutionary rewiring of the dynamic network underpinning allosteric epistasis in NS1 of the influenza A virus. Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2410.  Abstract  
submitted by kickingbird at Feb, 22, 2025 from Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2410 (via https://www.pnas.org/doi/10.1073/pnas.2410813122)
Viral proteins frequently mutate to evade host innate immune responses, yet the impact of these mutations on the molecular energy landscape remains unclear. Epistasis, the intramolecular communications ...

Schreiber A, Oberberg N, Ambrosy B, Rodner F, Kuma. Influenza H5Nx Viruses are susceptible to MEK1/2 Inhibition by zapnometinib. Emerg Microbes Infect. 2025 Feb 20:2471022.  Abstract  
submitted by kickingbird at Feb, 22, 2025 from Emerg Microbes Infect. 2025 Feb 20:2471022 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
Highly pathogenic avian influenza A viruses (HPAIV) pose a significant threat to both animal and human health. These viruses have the potential to cause severe respiratory and systemic infections in birds ...

Cavicchio L, Campalto M, Carrino M, Lucchese L, Ce. Influenza in feral cat populations: insights from a study in North-East Italy. Front. Vet. Sci. 11:1439354.  Abstract  
submitted by kickingbird at Feb, 21, 2025 from Front. Vet. Sci. 11:1439354 (via https://www.frontiersin.org/journals/veterinary-science/arti)
Influenza A virus (IAV) can cause high morbidity and mortality in domestic and wild avian species and it is able to infect mammals as well. IAV in cats is sporadic and self-limiting but the recent findings ...

Giovanetti M, Ali S, Slavov SN, Azarian T, Cella E. Epidemiological Transitions in Influenza Dynamics in the United States: Insights from Recent Pandemic Challenges. Microorganisms. 2025; 13(3):469.  Abstract  
submitted by kickingbird at Feb, 21, 2025 from Microorganisms. 2025; 13(3):469 (via https://www.mdpi.com/2076-2607/13/3/469)
The SARS-CoV-2 pandemic has reshaped the epidemiological landscape of respiratory diseases, with profound implications for seasonal influenza. Nonpharmaceutical interventions implemented globally during ...

Huizi Li, etc.,al. Chicken C4BPM facilitates replication of H5N1 and H9N2 Avian Influenza Viruses by inhibiting the production of type I interferons. Poultry Science, Volume 104, Issue 3, March 2025.  Abstract  
submitted by kickingbird at Feb, 21, 2025 from Poultry Science, Volume 104, Issue 3, March 2025 (via https://www.sciencedirect.com/science/article/pii/S003257912)
Avian influenza viruses (AIVs) are potential pandemic of global concern, posing a major threat to both the poultry industry and human health. Host factors play a key role in the replication of AIVs, while ...

Samson Oladokun, Mohammadali Alizadeh, Amirul I Ma. Influenza A Virus Subtype H9N2 Infection Induces Respiratory Microbiota Dysbiosis in Chickens via Type-I Interferon-Mediated Mechanisms. FEMS Microbes, 2025;, xtaf001.  Abstract  
submitted by kickingbird at Feb, 21, 2025 from FEMS Microbes, 2025;, xtaf001 (via https://academic.oup.com/femsmicrobes/advance-article/doi/10)
Avian influenza virus (AIV) poses significant threats to poultry and human health. This study investigates the impact of H9N2 AIV infection on the respiratory microbiota of chickens using 16S rRNA gene ...

Albert Perlas, Tim Reska, Guillaume Croville, Ferr. Improvements in RNA and DNA nanopore sequencing allow for rapid genetic characterization of avian influenza. Virus Evolution, 2025;, veaf010.  Abstract  
submitted by kickingbird at Feb, 21, 2025 from Virus Evolution, 2025;, veaf010 (via https://academic.oup.com/ve/advance-article/doi/10.1093/ve/v)
Avian influenza virus (AIV) currently causes a panzootic with extensive mortality in wild birds, poultry, and wild mammals, thus posing a major threat to global health and underscoring the need for efficient ...

Naraharisetti R, Weinberg M, Stoddard B, et al. Highly Pathogenic Avian Influenza A(H5N1) Virus Infection of Indoor Domestic Cats Within Dairy Industry Worker Households - Michigan, May 2024. MMWR Morb Mortal Wkly Rep 2025;74:61-65.  Abstract  
submitted by kickingbird at Feb, 21, 2025 from MMWR Morb Mortal Wkly Rep 2025;74:61-65 (via https://www.cdc.gov/mmwr/volumes/74/wr/mm7405a2.htm)
Highly pathogenic avian influenza (HPAI) A(H5N1) virus, clade 2.3.4.4b, genotype B3.13 infection has been documented in cats on U.S. dairy cattle farms. In May 2024, the detection of HPAI A(H5N1) virus ...

Li X, Li L, Tian J, Su R, Sun J, Li Y, Wang L, Zho. SREBP2-dependent lipid droplet formation enhances viral replication and deteriorates lung injury in mice following IAV infection. Emerg Microbes Infect. 2025 Feb 19:2470371.  Abstract  
submitted by kickingbird at Feb, 20, 2025 from Emerg Microbes Infect. 2025 Feb 19:2470371 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
Influenza A virus (IAV) is a significant zoonotic pathogen that poses a considerable challenge to public health due to its continuous mutations. Lipid droplets (LDs) have been shown to play an important ...

Signore AV, Joseph T, Ranadheera C, Erdelyan CNG,. Neuraminidase reassortment and oseltamivir resistance in clade 2.3.4.4b A(H5N1) viruses circulating among Canadian poultry, 2024. Emerg Microbes Infect. 2025 Feb 18:2469643.  Abstract  
submitted by kickingbird at Feb, 20, 2025 from Emerg Microbes Infect. 2025 Feb 18:2469643 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
We report the detection of a clade 2.3.4.4b A(H5N1) reassortant virus with a neuraminidase surface protein derived from a North American lineage low-pathogenic avian influenza virus. This virus caused ...

Wu J, Zhang X, Zhao Y, Zhang S, Wang Y, Yang W, Li. North American-Origin Influenza A (H10) viruses in Eurasian Wild Birds (2022-2024): Implications for the Emergence of Human H10N5 Virus. Emerg Microbes Infect. 2025 Feb 17:2465308.  Abstract  
submitted by kickingbird at Feb, 18, 2025 from Emerg Microbes Infect. 2025 Feb 17:2465308 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
During our surveillance of avian influenza viruses (AIVs) in wild birds across China, H10Nx viruses were isolated from diverse migratory flyways between 2022 and 2024. We identified one wild-bird H10N5 ...

Cheng Z, Sun Y, Shen Y, Wu X, Pan L, Wu H, Bai Y,. A Single Mutation at Position 214 of Influenza B Hemagglutinin Enhances Cross-Neutralization. Emerg Microbes Infect. 2025 Feb 17:2467770.  Abstract  
submitted by kickingbird at Feb, 18, 2025 from Emerg Microbes Infect. 2025 Feb 17:2467770 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
High variability of influenza B virus (IBV) hemagglutinin (HA) impairs the cross- neutralization ability of vaccines, leading to reduce efficacy. We identified significant differences in cross-neutralization ...

Oona Liedes, etc.,al. [preprint]Inactivated Zoonotic Influenza A(H5N8) Vaccine Induces Robust Antibody Responses Against Recent Highly Pathogenic Avian Influenza Clade 2.3.4.4b A(H5N1) Viruses. https://doi.org/10.1101/2025.02.12.25322044.  Abstract  
submitted by kickingbird at Feb, 17, 2025 from https://doi.org/10.1101/2025.02.12.25322044 (via https://www.medrxiv.org/content/10.1101/2025.02.12.25322044v)
In 2023, Finland faced an outbreak of highly pathogenic avian influenza caused by clade 2.3.4.4b A(H5N1) viruses, which spread from wild birds to fur farms. Vaccinations of individuals at-risk, such as ...

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