Martins de Camargo M, Caetano AR, Ferreira de Mira. Evolutionary pressures rendered by animal husbandry practices for avian influenza viruses to adapt to humans. iScience. 2022 Mar 1;25(4):104005. Abstract
submitted by kickingbird at Mar, 24, 2022 from iScience. 2022 Mar 1;25(4):104005 (via https://www.cell.com/iscience/fulltext/S2589-0042(22)00275-9)
Commercial poultry operations produce and crowd billions of birds every year, which is a source of inexpensive animal protein. Commercial poultry is intensely bred for desirable production traits, and ...
Brown SK, Tseng YY, Aziz A, Baz M, Barr IG. Characterization of influenza B viruses with reduced susceptibility to influenza neuraminidase inhibitors. Antiviral Res. 2022 Mar 15:105280. Abstract
submitted by kickingbird at Mar, 20, 2022 from Antiviral Res. 2022 Mar 15:105280 (via https://www.sciencedirect.com/science/article/pii/S016635422)
A total of 3425 influenza B viruses collected from the Asia-Pacific region were tested against the four registered neuraminidase inhibitors (NAIs) (oseltamivir carboxylate, zanamivir, peramivir and laninamivir) ...
Li G, Feng J, Quan K, Sun Z, Yin Y, Yin Y, Chen S,. Generation of an avian influenza DIVA vaccine with a H3-peptide replacement located at HA2 against both highly and low pathogenic H7N9 virus. Virulence. 2022 Dec;13(1):530-541. Abstract
submitted by kickingbird at Mar, 17, 2022 from Virulence. 2022 Dec;13(1):530-541 (via https://www.tandfonline.com/doi/full/10.1080/21505594.2022.2)
A differentiating infected from vaccinated animals (DIVA) vaccine is an ideal strategy for viral eradication in poultry. Here, according to the emerging highly pathogenic H7N9 avian influenza virus (AIV), ...
Engelsma M, Heutink R, Harders F, Germeraad EA, Be. Multiple Introductions of Reassorted Highly Pathogenic Avian Influenza H5Nx Viruses Clade 184.108.40.206b Causing Outbreaks in Wild Birds and Poultry in The Netherlands, 2020-2021. Microbiol Spectr. 2022 Mar 14:e0249921. Abstract
submitted by kickingbird at Mar, 17, 2022 from Microbiol Spectr. 2022 Mar 14:e0249921 (via https://journals.asm.org/doi/10.1128/spectrum.02499-21)
Highly pathogenic avian influenza (HPAI) viruses of subtype H5Nx caused outbreaks in poultry, captive birds, and wild birds in the Netherlands between October 2020 and June 2021. The full genome sequences ...
Zhang M, Xu K, Dai Q, You D, Yu Z, Bao C, Zhao Y. A dynamic model for individualized prognosis prediction in patients with avian influenza A H7N9. Ann Transl Med. 2022 Feb;10(3):149. Abstract
submitted by kickingbird at Mar, 17, 2022 from Ann Transl Med. 2022 Feb;10(3):149 (via https://atm.amegroups.com/article/view/87357/html)
Background: Avian influenza A H7N9 progresses rapidly and has a high case fatality rate. However, few models are available to predict the survival of individual patients with H7N9 infection in real-time. ...
Milder FJ, Jongeneelen M, Ritschel T, Bouchier P,. Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e21153. Abstract
submitted by kickingbird at Feb, 9, 2022 from Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e21153 (via https://www.pnas.org/content/119/6/e2115379119)
For an efficacious vaccine immunogen, influenza hemagglutinin (HA) needs to maintain a stable quaternary structure, which is contrary to the inherently dynamic and metastable nature of class I fusion proteins. ...
Huang K, Mao H, Ren P, Zhang Y, Sun X, Zou Z, Jin. 139D in NS1 Contributes to the Virulence of H5N6 Influenza Virus in Mice. Front Vet Sci. 2022 Jan 21;8:808234. Abstract
submitted by kickingbird at Feb, 8, 2022 from Front Vet Sci. 2022 Jan 21;8:808234 (via https://www.frontiersin.org/articles/10.3389/fvets.2021.8082)
H5N6, the highly pathogenic avian influenza A virus (IAV) of clade 220.127.116.11, causes global outbreaks in poultry. H5N6 has become the dominant IAV subtype in waterfowls and causes human infections with high ...
Bu L, Chen B, Xing L, Cai X, Liang S, Zhang L,Wang. Generation of a pdmH1N1 2018 Influenza A Reporter Virus Carrying a mCherry Fluorescent Protein in the PA Segment. Front Cell Infect Microbiol. 2022 Jan 20;11:827790. Abstract
submitted by kickingbird at Feb, 8, 2022 from Front Cell Infect Microbiol. 2022 Jan 20;11:827790 (via https://www.frontiersin.org/articles/10.3389/fcimb.2021.8277)
Influenza A virus (IAV) is a major human pathogen associated with significant morbidity and mortality worldwide. Through serial passage in mice, we generated a recombinant pdmH1N1 2009 IAV, A/Guangdong/GLW/2018 ...
Zheng Y, Guo Y, Li Y, Liang B, Sun X, Li S, Xia H,. The molecular determinants of antigenic drift in a novel avian influenza A (H9N2) variant virus. Virol J. 2022 Feb 5;19(1):26. Abstract
submitted by kickingbird at Feb, 8, 2022 from Virol J. 2022 Feb 5;19(1):26 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: In early 2020, a novel H9N2 AIV immune escape variant emerged in South China and rapidly spread throughout mainland China. The effectiveness of the current H9N2 vaccine is being challenged ...
Gu M, Zhao Y, Ge Z, Li Y, Gao R, Wang X, Hu J, Liu. Effects of HA2 154 deglycosylation and NA V202I mutation on biological property of H5N6 subtype avian influenza virus. Vet Microbiol. 2022 Jan 22;266:109353. Abstract
submitted by kickingbird at Feb, 7, 2022 from Vet Microbiol. 2022 Jan 22;266:109353 (via https://www.sciencedirect.com/science/article/pii/S037811352)
In recent years, clade 18.104.22.168 H5N6 subtype avian influenza virus (AIV) has been predominantly prevalent in poultry flocks in China. During our AIV surveillance in 2018-2019, 6 circulating strains of H5N6 ...
Seibert B, Cardenas-Garcia S, Rajao D, Perez DR. Reverse Genetics for Influenza A and B Viruses Driven by Swine Polymerase I Promoter. Methods Mol Biol. 2022;2465:257-281. Abstract
submitted by kickingbird at Feb, 5, 2022 from Methods Mol Biol. 2022;2465:257-281 (via https://link.springer.com/protocol/10.1007%2F978-1-0716-2168)
Influenza viruses are considered prominent pathogens of humans and animals that are extensively investigated because of public health importance. Plasmid-based reverse genetics is a fundamental tool that ...
Nogales A, Chiem K, Breen M, DeDiego ML, Parrish C. Generation and Characterization of Single-Cycle Infectious Canine Influenza A Virus (sciCIV) and Its Use as Vaccine Platform. Methods Mol Biol. 2022;2465:227-255. Abstract
submitted by kickingbird at Feb, 5, 2022 from Methods Mol Biol. 2022;2465:227-255 (via https://link.springer.com/protocol/10.1007%2F978-1-0716-2168)
Influenza A viruses (IAVs) infect a broad range of hosts, including multiple avian and mammalian species. The frequent emergence of novel IAV strains in different hosts, including in humans, results in ...
Li Z, Kim KH, Bhatnagar N, Park BR, Jeeva S, Jung. Physical radiofrequency adjuvant enhances immune responses to influenza H5N1 vaccination. FASEB J. 2022 Mar;36(3):e22182.. Abstract
submitted by kickingbird at Feb, 4, 2022 from FASEB J. 2022 Mar;36(3):e22182. (via https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.2021017)
Pre-pandemic influenza H5N1 vaccine has relatively low immunogenicity and often requires high antigen amounts and two immunizations to induce protective immunity. Incorporation of vaccine adjuvants is ...
Yehia N, Erfan AM, Adel A, El-Tayeb A, Hassan WMM,. Pathogenicity of three genetically distinct and highly pathogenic Egyptian H5N8 avian influenza viruses in chickens. Poult Sci. 2021 Dec 10;101(3):101662. Abstract
submitted by kickingbird at Feb, 2, 2022 from Poult Sci. 2021 Dec 10;101(3):101662 (via https://www.sciencedirect.com/science/article/pii/S003257912)
In late 2016, Egypt encountered multiple cases of the highly pathogenic avian influenza (HPAI) virus of the H5N8 subtype. In a previous study, three distinct genotypes, including A/common-coot/Egypt/CA285/2016 ...
Cui H, Che G, de Jong MCM, Li X, Liu Q, Yang J, Te. The PB1 gene from H9N2 avian influenza virus showed high compatibility and increased mutation rate after reassorting with a human H1N1 influenza virus. Virol J. 2022 Jan 25;19(1):20. Abstract
submitted by kickingbird at Jan, 28, 2022 from Virol J. 2022 Jan 25;19(1):20 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: Reassortment between human and avian influenza viruses (AIV) may result in novel viruses with new characteristics that may threaten human health when causing the next flu pandemic. A particular ...
Wan X, Li J, Wang Y, Yu X, He X, Shi J, Deng G, Ze. H7N9 virus infection triggers lethal cytokine storm by activating gasdermin E-mediated pyroptosis of lung alveolar epithelial cells. Natl Sci Rev. 2021 Jul 30;9(1):nwab137. Abstract
submitted by kickingbird at Jan, 28, 2022 from Natl Sci Rev. 2021 Jul 30;9(1):nwab137 (via https://academic.oup.com/nsr/article/9/1/nwab137/6332297)
The H7N9 influenza virus emerged in China in 2013, causing more than 1560 human infections, 39% of which were fatal. A 'cytokine storm' in the lungs of H7N9 patients has been linked to a poor prognosis ...
Taniguchi K, Ando Y, Kobayashi M, Toba S, Nobori H. Characterization of the In Vitro and In Vivo Efficacy of Baloxavir Marboxil against H5 Highly Pathogenic Avian Influenza Virus Infection. Viruses. 2022 Jan 8;14(1):111. Abstract
submitted by kickingbird at Jan, 25, 2022 from Viruses. 2022 Jan 8;14(1):111 (via https://www.mdpi.com/1999-4915/14/1/111)
Human infections caused by the H5 highly pathogenic avian influenza virus (HPAIV) sporadically threaten public health. The susceptibility of HPAIVs to baloxavir acid (BXA), a new class of inhibitors for ...
Liao Y, Guo S, Liu G, Qiu Z, Wang J, Yang D, Tian. Host Non-Coding RNA Regulates Influenza A Virus Replication. Viruses. 2021 Dec 29;14(1):51. Abstract
submitted by kickingbird at Jan, 25, 2022 from Viruses. 2021 Dec 29;14(1):51 (via https://www.mdpi.com/1999-4915/14/1/51)
Outbreaks of influenza, caused by the influenza A virus (IAV), occur almost every year in various regions worldwide, seriously endangering human health. Studies have shown that host non-coding RNA is an ...
Chiapponi C, Prosperi A, Moreno A, Baioni L, Facci. Genetic Variability among Swine Influenza Viruses in Italy: Data Analysis of the Period 2017-2020. Viruses. 2021 Dec 28;14(1):47. Abstract
submitted by kickingbird at Jan, 25, 2022 from Viruses. 2021 Dec 28;14(1):47 (via https://www.mdpi.com/1999-4915/14/1/47)
Swine play an important role in the ecology of influenza A viruses (IAVs), acting as mixing vessels. Swine (sw) IAVs of H1N1 (including H1N1pdm09), H3N2, and H1N2 subtypes are enzootic in pigs globally, ...
Chen Z, Zeng Y, Wei Y, Wang Q, Liu M, Zhang B, Liu. Influenza D virus Matrix protein 1 restricts the type I interferon response by degrading TRAF6. Virology. 2022 Jan 13;568:1-11. Abstract
submitted by kickingbird at Jan, 25, 2022 from Virology. 2022 Jan 13;568:1-11 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza D virus (IDV) is an emerged virus that was first isolated in 2011 in the United States. Evidence suggests that IDV has broad host tropism and zoonotic potential. However, the immune evasion mechanism ...
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