Music N, et al. Repeated vaccination against matched H3N2 influenza virus gives less protection than single vaccination in ferrets. NPJ Vaccines. 2019 Jul 9;4:28.. Abstract
submitted by kickingbird at Jul, 19, 2019 from NPJ Vaccines. 2019 Jul 9;4:28. (via https://www.nature.com/articles/s41541-019-0123-7)
Epidemiological studies suggest that humans who receive repeated annual immunization with influenza vaccine are less well protected against influenza than those who receive vaccine in the current season ...
Minagawa Y, Ueno H, Tabata KV, Noji H. Mobile imaging platform for digital influenza virus counting. Lab Chip. 2019 Jul 17. Abstract
submitted by kickingbird at Jul, 19, 2019 from Lab Chip. 2019 Jul 17 (via https://pubs.rsc.org/en/content/articlelanding/2019/LC/C9LC0)
Droplet-based digital bioassays enable highly sensitive and quantitative analysis of biomolecules, and are thought to be suitable for point-of-care diagnosis. However, digital bioassays generally require ...
Hinkula J, et al. Long-Lasting Mucosal and Systemic Immunity against Influenza A Virus Is Significantly Prolonged and Protective by Nasal Whole Influenza Immunization with Mucosal Adjuvant N3 and DNA-Plasmid Expressing. Vaccines (Basel). 2019 Jul 16;7(3).. Abstract
submitted by kickingbird at Jul, 19, 2019 from Vaccines (Basel). 2019 Jul 16;7(3). (via https://www.mdpi.com/2076-393X/7/3/64)
Background: Vaccination is commonly used to prevent and control influenza infection in humans. However, improvements in the ease of delivery and strength of immunogenicity could markedly improve herd immunity. ...
Von Holle TA, Moody MA. Influenza and Antibody-Dependent Cellular Cytotoxicity. Front Immunol. 2019 Jun 25;10:1457. Abstract
submitted by kickingbird at Jul, 19, 2019 from Front Immunol. 2019 Jun 25;10:1457 (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0145)
Despite the availability of yearly vaccinations, influenza continues to cause seasonal, and pandemic rises in illness and death. An error prone replication mechanism results in antigenic drift and viral ...
Hao XY, Li FD, Lv Q, Xu YF, Han YL, Gao H. Establishment of BALB/C mouse models of influenza A H1N1 aerosol inhalation. J Med Virol. 2019 Jul 18. Abstract
submitted by kickingbird at Jul, 19, 2019 from J Med Virol. 2019 Jul 18 (via https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25550)
Influenza A (H1N1) is a rapidly spreading acute respiratory illness that remains a worldwide burden on public health. To simulate natural infection routes, BALB/C mice were challenged with the H1N1 virus ...
Chen R, et al. Characterization of viral genomic mutations in novel influenza A (H7N9)-infected patients: the association between oseltamivir-resistant variants and viral shedding duration. Virus Genes. 2019 Jul 13. Abstract
submitted by kickingbird at Jul, 17, 2019 from Virus Genes. 2019 Jul 13 (via https://link.springer.com/article/10.1007%2Fs11262-019-01678)
Since February 2013, human infections with the novel influenza A H7N9 virus have occurred in eastern China. It is important to detect mutations in viral genes and analyze the clinical features of patients ...
Gao W, et al. Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cells. J Gen Virol. 2019 Jul 15.. Abstract
submitted by kickingbird at Jul, 17, 2019 from J Gen Virol. 2019 Jul 15. (via https://jgv.microbiologyresearch.org/content/journal/jgv/10.)
Adaptation of PB2 protein is important for the establishment of avian influenza viruses in mammalian hosts. Here, we identify I292V as the prevalent mutation in PB2 of circulating avian H9N2 and pandemic ...
Chen J, et al. Circulation, Evolution and Transmission of Highly Pathogenic Avian Influenza A (H5N8) virus, 2016~2018. J Infect. 2019 Jul 12. Abstract
submitted by kickingbird at Jul, 17, 2019 from J Infect. 2019 Jul 12 (via https://www.journalofinfection.com/article/S0163-4453(19)302)
OBJECTIVES: A second wave of highly pathogenic avian influenza A virus (HPAIV) H5N8 clade 126.96.36.199 has spread globally, causing outbreaks among wild birds and domestic poultry since autumn 2016. The circulation ...
Kingstad-Bakke BA, et al. Effective mosaic-based nanovaccines against avian influenza in poultry. Vaccine. 2019 Jul 9. Abstract
submitted by kickingbird at Jul, 15, 2019 from Vaccine. 2019 Jul 9 (via https://www.sciencedirect.com/science/article/pii/S0264410X1)
Avian influenza virus (AIV) is an extraordinarily diverse pathogen that causes significant morbidity in domesticated poultry populations and threatens human life with looming pandemic potential. Controlling ...
Rim A, et al. Viral interference between H9N2-low pathogenic avian influenza virus and avian infectious bronchitis virus vaccine strain H120 in vivo. Comp Immunol Microbiol Infect Dis. 2019 Aug;65:219. Abstract
submitted by kickingbird at Jul, 15, 2019 from Comp Immunol Microbiol Infect Dis. 2019 Aug;65:219 (via https://www.sciencedirect.com/science/article/pii/S014795711)
The interaction between a low pathogenic avian influenza virus (A/CK/TUN/145/2012), a H9N2 Tunisian isolate, and a vaccine strain (H120) of avian infectious bronchitis, administered simultaneously or sequentially ...
Li M, et al. A cross-reactive human monoclonal antibody targets the conserved H7 antigenic site a from fifth wave H7N9-infected humans. Antiviral Res. 2019 Jul 9:104556.. Abstract
submitted by kickingbird at Jul, 15, 2019 from Antiviral Res. 2019 Jul 9:104556. (via https://www.sciencedirect.com/science/article/pii/S016635421)
Subtype H7 avian influenza viruses have been found to be associated with human infection and represent a risk for global public health. In 2013, the emergence of H7N9 virus in human beings and persistent ...
Abood RN, et al. IL-22-binding protein exacerbates influenza, bacterial super-infection. Mucosal Immunol. 2019 Jul 11.. Abstract
submitted by kickingbird at Jul, 15, 2019 from Mucosal Immunol. 2019 Jul 11. (via https://www.nature.com/articles/s41385-019-0188-7)
Secondary bacterial pneumonia is a significant complication of severe influenza infection and Staphylococcus aureus and Streptococcus pneumoniae are the primary pathogens of interest. IL-22 promotes S. ...
Lee DH, et al. Genome Sequences of an H9N2 Avian Influenza Virus Strain Found in Pakistan in 2017. Microbiol Resour Announc. 2019 Jul 11;8(28).. Abstract
submitted by kickingbird at Jul, 15, 2019 from Microbiol Resour Announc. 2019 Jul 11;8(28). (via https://mra.asm.org/content/8/28/e00433-19)
In 2017, we isolated an H9N2 avian influenza virus in Pakistan. Genetic analysis showed that the A/chicken/Kasoor/SI36/2017(H9N2) isolate belongs to the G1 lineage. In addition, this isolate possesses ...
Mishin VP, Patel MC, Chesnokov A, De La Cruz J, Ng. Susceptibility of Influenza A, B, C, and D Viruses to Baloxavir. Emerg Infect Dis. 2019 Oct. Abstract
submitted by kickingbird at Jul, 12, 2019 from Emerg Infect Dis. 2019 Oct (via https://wwwnc.cdc.gov/eid/article/25/10/19-0607_article)
Baloxavir showed broad-spectrum in vitro replication inhibition of 4 types of influenza viruses (90% effective concentration range 1.2-98.3 nmol/L); susceptibility pattern was influenza A ? B ? C ? D. ...
Wang G, et al. Characterization of swine-origin H1N1 canine influenza viruses. Emerg Microbes Infect. 2019;8(1):1017-1026. Abstract
submitted by kickingbird at Jul, 12, 2019 from Emerg Microbes Infect. 2019;8(1):1017-1026 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1)
Host switch events of influenza A viruses (IAVs) continuously pose a zoonotic threat to humans. In 2013, swine-origin H1N1 IAVs emerged in dogs soon after they were detected in swine in the Guangxi province ...
Kode SS, et al. A novel I117T substitution in neuraminidase of highly pathogenic avian influenza H5N1 virus conferring reduced susceptibility to oseltamivir and zanamivir. Vet Microbiol. 2019 Jun 5;235:21-24.. Abstract
submitted by kickingbird at Jul, 12, 2019 from Vet Microbiol. 2019 Jun 5;235:21-24. (via https://www.sciencedirect.com/science/article/pii/S037811351)
Occurrence of avian influenza (AI) with Neuraminidase (NA) mutations which confer reduced neuraminidase inhibitor (NAI) susceptibility has remained a cause of concern. The susceptibility to NAIs of 67 ...
Peacock TP, Sheppard CM, Staller E, Barclay WS. Host Determinants of Influenza RNA Synthesis. Annu Rev Virol. 2019 Jul 5. Abstract
submitted by kickingbird at Jul, 12, 2019 from Annu Rev Virol. 2019 Jul 5 (via https://www.annualreviews.org/doi/10.1146/annurev-virology-0)
Influenza viruses are a leading cause of seasonal and pandemic respiratory illness. Influenza is a negative-sense single-stranded RNA virus that encodes its own RNA-dependent RNA polymerase (RdRp) for ...
Huo C, et al. Genomic and Bioinformatic Characterization of Mouse Mast Cells (P815) Upon Different Influenza A Virus (H1N1, H5N1, and H7N2) Infections. Front Genet. 2019 Jun 21;10:595. Abstract
submitted by kickingbird at Jul, 12, 2019 from Front Genet. 2019 Jun 21;10:595 (via https://www.frontiersin.org/articles/10.3389/fgene.2019.0059)
Influenza A virus (IAV) is a segmented negative-stranded RNA virus that brings a potentially serious threat to public health and animal husbandry. Mast cells play an important role in both the inherent ...
Mei K, et al. Different Pathogenicity and Transmissibility of Goose-Origin H5N6 Avian Influenza Viruses in Chickens. Viruses. 2019 Jul 4;11(7).. Abstract
submitted by kickingbird at Jul, 10, 2019 from Viruses. 2019 Jul 4;11(7). (via https://www.mdpi.com/1999-4915/11/7/612)
Highly pathogenic avian influenza H5N6 viruses have been circulating in poultry in Asia since 2013 and producing serious diseases in chickens. Here, we analyzed the genetic properties of 10 H5N6 subtypes ...
To J, Torres J. Viroporins in the Influenza Virus. Cells. 2019 Jun 29;8(7).. Abstract
submitted by kickingbird at Jul, 7, 2019 from Cells. 2019 Jun 29;8(7). (via https://www.mdpi.com/2073-4409/8/7/654)
Influenza is a highly contagious virus that causes seasonal epidemics and unpredictable pandemics. Four influenza virus types have been identified to date: A, B, C, and D, where only A-C are known to infect ...
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