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2021-4-20 5:31:46
Article

Allen JD, Ross TM. Next generation methodology for updating HA vaccines against emerging human seasonal influenza A(H3N2) viruses. Sci Rep. 2021 Mar 2;11(1):4554.  Abstract  
submitted by kickingbird at Mar, 4, 2021 from Sci Rep. 2021 Mar 2;11(1):4554 (via https://www.nature.com/articles/s41598-020-79590-7)
While vaccines remain the best tool for preventing influenza virus infections, they have demonstrated low to moderate effectiveness in recent years. Seasonal influenza vaccines typically consist of wild-type ...

Yechezkel M, Ndeffo Mbah ML, Yamin D. Optimizing antiviral treatment for seasonal influenza in the USA: a mathematical modeling analysis. BMC Med. 2021 Mar 1;19(1):54.  Abstract  
submitted by kickingbird at Mar, 2, 2021 from BMC Med. 2021 Mar 1;19(1):54 (via https://bmcmedicine.biomedcentral.com/articles/10.1186/s1291)
Background: Seasonal influenza remains a major cause of morbidity and mortality in the USA. Despite the US Centers for Disease Control and Prevention recommendation promoting the early antiviral treatment ...

Mitchell PK, Cronk BD, Voorhees IEH, Rothenheber D. Method comparison of targeted influenza A virus typing and whole-genome sequencing from respiratory specimens of companion animals. J Vet Diagn Invest. 2020 Nov 24:1040638720933875.  Abstract  
submitted by kickingbird at Mar, 1, 2021 from J Vet Diagn Invest. 2020 Nov 24:1040638720933875 (via https://journals.sagepub.com/doi/10.1177/1040638720933875)
Epidemics of H3N8 and H3N2 influenza A viruses (IAVs) in dogs, along with recognition of spillover infections from IAV strains typically found in humans or other animals, have emphasized the importance ...

Elfaki Y, Robert PA, Binz C, Falk CS, Bruder D, Pr. Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development in mice. Eur J Immunol. 2021 Feb 26.  Abstract  
submitted by kickingbird at Feb, 28, 2021 from Eur J Immunol. 2021 Feb 26 (via https://onlinelibrary.wiley.com/doi/10.1002/eji.202048981)
Foxp3+ regulatory T (Treg) cells, which are crucial for maintenance of self-tolerance, mainly develop within the thymus, where they arise from CD25+ Foxp3- or CD25- Foxp3+ Treg cell precursors. Although ...

Li X, Xie S, Jiang X, Li Z, Xu L, Wen K, Zhang M,. Emergence of one novel reassortment H3N8 avian influenza virus in China, originating from North America and Eurasia. Infect Genet Evol. 2021 Feb 24:104782.  Abstract  
submitted by kickingbird at Feb, 28, 2021 from Infect Genet Evol. 2021 Feb 24:104782 (via https://www.sciencedirect.com/science/article/abs/pii/S15671)
No abstract available

Radvak P, Kosikova M, Kuo YC, Li X, Garner R, Schm. Highly pathogenic avian influenza A/Guangdong/17SF003/2016 is immunogenic and induces cross-protection against antigenically divergent H7N9 viruses. NPJ Vaccines. 2021 Feb 26;6(1):30.  Abstract  
submitted by kickingbird at Feb, 27, 2021 from NPJ Vaccines. 2021 Feb 26;6(1):30 (via https://www.nature.com/articles/s41541-021-00295-7)
Avian influenza A(H7N9) epidemics have a fatality rate of approximately 40%. Previous studies reported that low pathogenic avian influenza (LPAI)-derived candidate vaccine viruses (CVVs) are poorly immunogenic. ...

Xiao Y, Yang F, Liu F, Yao H, Wu N, Wu H. Development and application of a real-time RT-PCR assay to rapidly detect H2 subtype avian influenza A viruses. J Vet Diagn Invest. 2021 Feb 22:1040638721994810.  Abstract  
submitted by kickingbird at Feb, 25, 2021 from J Vet Diagn Invest. 2021 Feb 22:1040638721994810 (via https://journals.sagepub.com/doi/10.1177/1040638721994810)
The H2 subtypes of avian influenza A viruses (avian IAVs) have been circulating in poultry, and they have the potential to infect humans. Therefore, establishing a method to quickly detect this subtype ...

Bullard BL, Corder BN, DeBeauchamp J, Rubrum A, Ko. Epigraph hemagglutinin vaccine induces broad cross-reactive immunity against swine H3 influenza virus. Nat Commun. 2021 Feb 22;12(1):1203.  Abstract  
submitted by kickingbird at Feb, 25, 2021 from Nat Commun. 2021 Feb 22;12(1):1203 (via https://www.nature.com/articles/s41467-021-21508-6)
Influenza A virus infection in swine impacts the agricultural industry in addition to its zoonotic potential. Here, we utilize epigraph, a computational algorithm, to design a universal swine H3 influenza ...

Chen S, Quan K, Wang H, Li S, Xue J, Qin T, Chu D,. A Live Attenuated H9N2 Avian Influenza Vaccine Prevents the Viral Reassortment by Exchanging the HA and NS1 Packaging Signals. Front Microbiol. 2021 Feb 4;11:613437.  Abstract  
submitted by kickingbird at Feb, 23, 2021 from Front Microbiol. 2021 Feb 4;11:613437 (via https://www.frontiersin.org/articles/10.3389/fmicb.2020.6134)
The H9N2 avian influenza virus is not only an important zoonotic pathogen, it can also easily recombine with other subtypes to generate novel reassortments, such as the H7N9 virus. Although H9N2 live attenuated ...

Kim YC, Won SY, Jeong BH. The first association study of single-nucleotide polymorphisms (SNPs) of the IFITM1 gene with influenza H1N1 2009 pandemic virus infection. Mol Cell Toxicol. 2021 Feb 15:1-8.  Abstract  
submitted by kickingbird at Feb, 23, 2021 from Mol Cell Toxicol. 2021 Feb 15:1-8 (via https://link.springer.com/article/10.1007/s13273-021-00123-y)
Background: The interferon-induced transmembrane (IFITM) protein family consists of interferon-stimulated genes (ISGs) that show potent antiviral capacity against a broad range of viruses. Many studies ...

Khalil AM, Yoshida R, Masatani T, Takada A, Ozawa. Variation in the HA antigenicity of A(H1N1)pdm09-related swine influenza viruses. J Gen Virol. 2021 Feb 22.  Abstract  
submitted by kickingbird at Feb, 23, 2021 from J Gen Virol. 2021 Feb 22 (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Since the influenza pandemic in 2009, the causative agent 'A(H1N1)pdm09 virus', has been circulating in both human and swine populations. Although phylogenetic analyses of the haemagglutinin (HA) gene ...

Verhagen JH, Fouchier RAM, Lewis N. Highly Pathogenic Avian Influenza Viruses at the Wild-Domestic Bird Interface in Europe: Future Directions for Research and Surveillance. Viruses. 2021 Jan 30;13(2):212.  Abstract  
submitted by kickingbird at Feb, 22, 2021 from Viruses. 2021 Jan 30;13(2):212 (via https://www.mdpi.com/1999-4915/13/2/212)
Highly pathogenic avian influenza (HPAI) outbreaks in wild birds and poultry are no longer a rare phenomenon in Europe. In the past 15 years, HPAI outbreaks-in particular those caused by H5 viruses derived ...

Khalil AM, Fujimoto Y, Kojima I, Esaki M, Ri K, Ma. Genetic Characterization of H5N8 Highly Pathogenic Avian Influenza Viruses Isolated from Falcated Ducks and Environmental Water in Japan in November 2020. Pathogens. 2021 Feb 4;10(2):171.  Abstract  
submitted by kickingbird at Feb, 22, 2021 from Pathogens. 2021 Feb 4;10(2):171 (via https://www.mdpi.com/2076-0817/10/2/171)
We isolated two highly pathogenic avian influenza viruses (HPAIVs) of subtype H5N8 clade 2.3.4.4b from falcated duck (Anas falcata) feces and environmental water collected at an overwintering site in Japan. ...

Chen S, Wang X, Su X, Miao X, Qin T, Peng D, Liu X. Deep sequencing of the transcriptome from murine lung infected with H5N8 subtype avian influenza virus with combined substitutions I283M and K526R in PB2 gene. Infect Genet Evol. 2021 Jan;87:104672.  Abstract  
submitted by kickingbird at Feb, 22, 2021 from Infect Genet Evol. 2021 Jan;87:104672 (via https://www.sciencedirect.com/science/article/abs/pii/S15671)
H5N8 subtype highly pathogenic avian influenza viruses (HPAIVs) pose a huge threat to poultry industry and general public health. Our previous study demonstrated that synergistic effect of 283M and 526R ...

Rohaim MA, El Naggar RF, Madbouly Y, AbdelSabour M. Comparative infectivity and transmissibility studies of wild-bird and chicken-origin highly pathogenic avian influenza viruses H5N8 in chickens. Comp Immunol Microbiol Infect Dis. 2021 Feb;74:101.  Abstract  
submitted by kickingbird at Feb, 22, 2021 from Comp Immunol Microbiol Infect Dis. 2021 Feb;74:101 (via https://www.sciencedirect.com/science/article/abs/pii/S01479)
Despite the recent advances in avian influenza viruses surveillance and genomic data, fundamental questions concerning the ecology and evolution of these viruses remain elusive. In Egypt, H5N8 highly pathogenic ...

Youk SS, Leyson CM, Seibert BA, Jadhao S, Perez DR. Mutations in PB1, NP, HA, and NA Contribute to Increased Virus Fitness of H5N2 Highly Pathogenic Avian Influenza Virus Clade 2.3.4.4 in Chickens. J Virol. 2020 Dec 2:JVI.01675-20.  Abstract  
submitted by kickingbird at Feb, 22, 2021 from J Virol. 2020 Dec 2:JVI.01675-20 (via https://jvi.asm.org/content/95/5/e01675-20)
The H5N8 highly pathogenic avian influenza (HPAI) clade 2.3.4.4 virus spread to North America by wild birds and reassorted to generate the H5N2 HPAI virus that caused the poultry outbreak in the United ...

Sánchez-González R, Ramis A, Nofrarías M, Wali N,. Infectivity and pathobiology of H7N1 and H5N8 high pathogenicity avian influenza viruses for pigeons ( Columba livia var. domestica). Avian Pathol. 2021 Feb;50(1):98-106.  Abstract  
submitted by kickingbird at Feb, 22, 2021 from Avian Pathol. 2021 Feb;50(1):98-106 (via https://www.tandfonline.com/doi/abs/10.1080/03079457.2020.18)
Avian influenza (AI) is one of the most important viral diseases in poultry, wildlife and humans. Available data indicate that pigeons play a minimum role in the epidemiology of AI. However, a degree of ...

Pronier C, Gacouin A, Lagathu G, Le Tulzo Y, Tadié. Respiratory Influenza viral load as a marker of poor prognosis in patients with severe symptoms. J Clin Virol. 2021 Feb 12;136:104761.  Abstract  
submitted by kickingbird at Feb, 22, 2021 from J Clin Virol. 2021 Feb 12;136:104761 (via https://www.sciencedirect.com/science/article/abs/pii/S13866)
Background: The link between influenza virus (IV) viral load (VL) in respiratory samples and disease severity is not clearly established. This study was designed to assess IV-VL in respiratory samples ...

Park BR, Kim KH, Kotomina T, Kim MC, Kwon YM, Jeev. Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin. Sci Rep. 2021 Feb 18;11(1):4151.  Abstract  
submitted by kickingbird at Feb, 20, 2021 from Sci Rep. 2021 Feb 18;11(1):4151 (via https://pubmed.ncbi.nlm.nih.gov/33603072/)
Hemagglutinin (HA)-based current vaccines provide suboptimum cross protection. Influenza A virus contains an ion channel protein M2 conserved extracellular domain (M2e), a target for developing universal ...

Liu L, Li Z, Zhou J, Lu J, Li X, Liu J, Xiao N, Wa. The effect of single amino acid substitution at position 220 in the hemagglutinin glycoprotein on avian influenza H7N9 candidate vaccine virus. Virus Genes. 2021 Feb 19.  Abstract  
submitted by kickingbird at Feb, 20, 2021 from Virus Genes. 2021 Feb 19 (via https://link.springer.com/article/10.1007/s11262-021-01827-y)
Influenza vaccines represent the most effective preventive strategy to control influenza virus infections; however, adaptive mutations frequently occur in the hemagglutinin (HA) glycoprotein during the ...

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