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Lee YN, etc.,al. Pathogenesis and genetic characteristics of novel reassortant low-pathogenic avian influenza H7 viruses isolated from migratory birds in the Republic of Korea in the winter of 2016~2017. Emerg Microbes Infect. 2018 Nov 15;7(1):182.  Abstract  
submitted by kickingbird at Nov, 19, 2018 from Emerg Microbes Infect. 2018 Nov 15;7(1):182 (via https://www.ncbi.nlm.nih.gov/pubmed/30442892)
In this study, we characterized H7 subtype low-pathogenicity (LP) influenza A viruses (IAVs) isolated from wild bird habitats in the Republic of Korea from 2010 to early 2017. Through national surveillance, ...

Yoon SJ, et al. Optimized Expression, Purification, and Rapid Detection of Recombinant Influenza Nucleoproteins Expressed in Sf9 Insect Cells. J Microbiol Biotechnol. 2018 Oct 28;28(10):1683-16.  Abstract  
submitted by kickingbird at Nov, 19, 2018 from J Microbiol Biotechnol. 2018 Oct 28;28(10):1683-16 (via https://www.ncbi.nlm.nih.gov/pubmed/30441884)
Accurate and rapid diagnosis of influenza infection is essential to enable early antiviral treatment and reduce the mortality associated with seasonal and epidemic infections. Immunochromatography is one ...

Miyagawa T, et al. A Novel Diagnostic System for Infectious Diseases Using Solid-State Nanopore Devices. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:283.  Abstract  
submitted by kickingbird at Nov, 19, 2018 from Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:283 (via https://www.ncbi.nlm.nih.gov/pubmed/30440991)
Nanopore-based diagnostic systems are a promising tool for counting viruses in a specimen one by one. However, despite intensive R&D efforts, it remains difficult to recognize virus subtypes by nanopore ...

Zhao H, et al. A neuraminidase activity-based microneutralization assay for evaluating antibody responses to influenza H5 and H7 vaccines. PLoS One. 2018 Nov 15;13(11):e0207431.  Abstract  
submitted by kickingbird at Nov, 19, 2018 from PLoS One. 2018 Nov 15;13(11):e0207431 (via https://www.ncbi.nlm.nih.gov/pubmed/30440054)
Outbreaks of the highly pathogenic avian influenza H5N1 and H7N9 viruses have spurred an unprecedented research effort to develop antivirals and vaccines against influenza. Standardized methods for vaccine ...

Desirò D, H?lzer M, Ibrahim B, Marz M. SilentMutations (SIM): a tool for analyzing long-range RNA-RNA interactions in viral genomes and structured RNAs. Virus Res. 2018 Nov 12..  Abstract  
submitted by kickingbird at Nov, 17, 2018 from Virus Res. 2018 Nov 12. (via https://www.ncbi.nlm.nih.gov/pubmed/30439394)
A single nucleotide change in the coding region can alter the amino acid sequence of a protein. In consequence, natural or artificial sequence changes in viral RNAs may have various effects not only on ...

Barbezange C, et al. Seasonal Genetic Drift of Human Influenza A Virus Quasispecies Revealed by Deep Sequencing. Front Microbiol. 2018 Oct 31;9:2596..  Abstract  
submitted by kickingbird at Nov, 17, 2018 from Front Microbiol. 2018 Oct 31;9:2596. (via https://www.ncbi.nlm.nih.gov/pubmed/30429836)
After a pandemic wave in 2009 following their introduction in the human population, the H1N1pdm09 viruses replaced the previously circulating, pre-pandemic H1N1 virus and, along with H3N2 viruses, are ...

Allen JD, et al. Elicitation of protective antibodies against 20 years of future H3N2 co-ciruculating influenza virus variants in ferrets preimmune to historical H3N2 influenza viruses. J Virol. 2018 Nov 14..  Abstract  
submitted by kickingbird at Nov, 17, 2018 from J Virol. 2018 Nov 14. (via https://www.ncbi.nlm.nih.gov/pubmed/30429350)
The vast majority of people already have pre-existing immune responses to influenza viruses from one or more subtypes. However, almost all preclinical studies evaluate new influenza vaccine candidates ...

Beyleveld G, et al. Nucleolar Relocalization of RBM14 by Influenza A Virus NS1 Protein. mSphere. 2018 Nov 14;3(6)..  Abstract  
submitted by kickingbird at Nov, 17, 2018 from mSphere. 2018 Nov 14;3(6). (via https://www.ncbi.nlm.nih.gov/pubmed/30429226)
Viruses utilize a number of host factors in order to carry out their replication cycles. Influenza A virus (IAV) and human respiratory syncytial virus (RSV) both infect the tissues of the respiratory tract, ...

Ye F, et al. Analysis of influenza B virus lineages and the HA1 domain of its hemagglutinin gene in Guangzhou, southern China, during 2016. Virol J. 2018 Nov 14;15(1):175.  Abstract  
submitted by kickingbird at Nov, 17, 2018 from Virol J. 2018 Nov 14;15(1):175 (via https://www.ncbi.nlm.nih.gov/pubmed/30428893)
BACKGROUND: Few studies have analyzed influenza B virus lineages based on hemagglutinin A (HA) gene sequences in southern China. The present study analyzed the HA gene and the lineages of influenza B virus ...

Hilton SK, Bloom JD. Modeling site-specific amino-acid preferences deepens phylogenetic estimates of viral sequence divergence. Virus Evol. 2018 Nov 6;4(2):vey033.  Abstract  
submitted by kickingbird at Nov, 17, 2018 from Virus Evol. 2018 Nov 6;4(2):vey033 (via https://www.ncbi.nlm.nih.gov/pubmed/30425841)
Molecular phylogenetics is often used to estimate the time since the divergence of modern gene sequences. For highly diverged sequences, such phylogenetic techniques sometimes estimate surprisingly recent ...

Song L, Xiong D, Kang X, Jiao Y, et al.. The optimized fusion protein HA1-2-FliCâ–³D2D3 promotes mixed Th1/Th2 immune responses to influenza H7N9 with low induction of systemic proinflammatory cytokines in mice. Antiviral Res 2018 Oct 30.  Abstract  
submitted by kickingbird at Nov, 15, 2018 from Antiviral Res 2018 Oct 30 (via https://www.ncbi.nlm.nih.gov/pubmed/30389471)
H7N9 influenza virus has an unusually high fatality rate of approximately 40%, and a safe and effective vaccine against this subtype is urgently needed. Flagellin, a Toll-like receptor (TLR) 5 agonist, ...

Jia X, et al. Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration. PLoS Pathog. 2018 Nov 13;14(11):.  Abstract  
submitted by kickingbird at Nov, 15, 2018 from PLoS Pathog. 2018 Nov 13;14(11): (via https://www.ncbi.nlm.nih.gov/pubmed/30422993)
Severe influenza A virus infection causes high mortality and morbidity worldwide due to delayed antiviral treatment and inducing overwhelming immune responses, which contribute to immunopathological lung ...

Chen T, Xiao M, Yang J, Chen YK, Bai T, et al. Association between rs12252 and influenza susceptibility and severity: an updated meta-analysis. Epidemiol Infect. 2018 Nov 13:1-9.  Abstract  
submitted by kickingbird at Nov, 15, 2018 from Epidemiol Infect. 2018 Nov 13:1-9 (via https://www.ncbi.nlm.nih.gov/pubmed/30421689)
In several lately published studies, the association between single-nucleotide polymorphism (SNP, rs12252) of IFITM3 and the risk of influenza is inconsistent. To further understand the association between ...

Littauer EQ, Skountzou I. Hormonal Regulation of Physiology, Innate Immunity and Antibody Response to H1N1 Influenza Virus Infection During Pregnancy. Front Immunol. 2018 Oct 29;9:2455.  Abstract  
submitted by kickingbird at Nov, 15, 2018 from Front Immunol. 2018 Oct 29;9:2455 (via https://www.ncbi.nlm.nih.gov/pubmed/30420854)
In 2009, the H1N1 swine flu pandemic highlighted the vulnerability of pregnant women to influenza viral infection. Pregnant women infected with influenza A virus were at increased risk of hospitalization ...

Lee KM, et al. Coinfection With Influenza A Virus and Klebsiella oxytoca: An Underrecognized Impact on Host Resistance and Tolerance to Pulmonary Infections. Front Immunol. 2018 Oct 29;9:2377.  Abstract  
submitted by kickingbird at Nov, 15, 2018 from Front Immunol. 2018 Oct 29;9:2377 (via https://www.ncbi.nlm.nih.gov/pubmed/30420852)
Pneumonia is a world health problem and a leading cause of death, particularly affecting children and the elderly (1, 2). Bacterial pneumonia following infection with influenza A virus (IAV) is associated ...

Wohlgemuth N, Lane AP, Pekosz A. Influenza A Virus M2 Protein Apical Targeting Is Required for Efficient Virus Replication. J Virol. 2018 Oct 29;92(22)..  Abstract  
submitted by kickingbird at Nov, 13, 2018 from J Virol. 2018 Oct 29;92(22). (via https://www.ncbi.nlm.nih.gov/pubmed/30158290)
The influenza A virus (IAV) M2 protein is a multifunctional protein with critical roles in virion entry, assembly, and budding. M2 is targeted to the apical plasma membrane of polarized epithelial cells, ...

Ather JL, et al. Serum Amyloid A3 is required for normal lung development and survival following influenza infection. Sci Rep. 2018 Nov 8;8(1):16571..  Abstract  
submitted by kickingbird at Nov, 13, 2018 from Sci Rep. 2018 Nov 8;8(1):16571. (via https://www.ncbi.nlm.nih.gov/pubmed/30410021)
Serum amyloid A (SAA) proteins are a family of acute phase apolipoproteins implicated to directly modulate innate and adaptive immune responses. However, new studies comparing endogenous SAAs and recombinant ...

Mine J, et al. Genetic and antigenic dynamics of influenza A viruses of swine on pig farms in Thailand. Arch Virol. 2018 Nov 10..  Abstract  
submitted by kickingbird at Nov, 13, 2018 from Arch Virol. 2018 Nov 10. (via https://www.ncbi.nlm.nih.gov/pubmed/30415389)
Surveillance studies of influenza A virus of swine (IAV-S) have accumulated information regarding IAVs-S circulating in Thailand, but how IAVs-S evolve within a farm remains unclear. In the present study, ...

Franklin AB, et al. Predicting the initial spread of novel Asian origin influenza A viruses in the continental United States by wild waterfowl. Transbound Emerg Dis. 2018 Nov 11..  Abstract  
submitted by kickingbird at Nov, 13, 2018 from Transbound Emerg Dis. 2018 Nov 11. (via https://www.ncbi.nlm.nih.gov/pubmed/30415502)
Using data on waterfowl band recoveries, we identified spatially-explicit hotspots of concentrated waterfowl movement to predict occurrence and spatial spread of a novel influenza A virus (clade 2.3.4.4) ...

Peacock TP, et al. The molecular basis of antigenic variation among A(H9N2) avian influenza viruses. Emerg Microbes Infect. 2018 Nov 7;7(1):176..  Abstract  
submitted by kickingbird at Nov, 11, 2018 from Emerg Microbes Infect. 2018 Nov 7;7(1):176. (via https://www.ncbi.nlm.nih.gov/pubmed/30401826)
Avian influenza A(H9N2) viruses are an increasing threat to global poultry production and, through zoonotic infection, to human health where they are considered viruses with pandemic potential. Vaccination ...

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