Cao Y, et al. Global transcriptome analysis of H5N1 influenza virus-infected human cells. Hereditas. 2019 Feb 6;156:10. Abstract
submitted by kickingbird at Feb, 20, 2019 from Hereditas. 2019 Feb 6;156:10 (via https://www.ncbi.nlm.nih.gov/pubmed/30774581)
Background: Influenza A virus (IAV) belongs to the Orthomyxoviridae family. IAV causes a highly contagious respiratory disease in humans that exacts severe economic losses globally. The virus uses strategies ...
Curthoys NM, et al. Influenza Hemagglutinin Modulates Phosphatidylinositol 4,5-bisphosphate Membrane Clustering. Biophys J. 2019 Jan 25.. Abstract
submitted by kickingbird at Feb, 20, 2019 from Biophys J. 2019 Jan 25. (via https://www.ncbi.nlm.nih.gov/pubmed/30773293)
The lipid phosphatidylinositol 4,5-bisphosphate (PIP2) forms nanoscopic clusters in cell plasma membranes; however, the processes determining PIP2 mobility and thus its spatial patterns are not fully understood. ...
Dumm RE, et al. Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function. Nat Commun. 2019 Feb 15;10(1):779. Abstract
submitted by kickingbird at Feb, 19, 2019 from Nat Commun. 2019 Feb 15;10(1):779 (via https://www.ncbi.nlm.nih.gov/pubmed/30770807)
Influenza B virus (IBV) is an acute, respiratory RNA virus that has been assumed to induce the eventual death of all infected cells. We and others have shown however, that infection with apparently cytopathic ...
Yeming Wang, et al. Comparative outcomes of adults hospitalized with seasonal influenza A or B virus infection: application of the seven-category ordinal scale. Open Forum Infectious Diseases 15 February 2019. Abstract
submitted by kickingbird at Feb, 19, 2019 from Open Forum Infectious Diseases 15 February 2019 (via https://academic.oup.com/ofid/advance-article/doi/10.1093/of)
ObjectiveTo investigate the difference of disease severity between influenza A and B among hospitalized adults using a novel ordinal scale and existing clinical outcome endpoints.MethodsA prospective, ...
James J, et al. The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells. J Gen Virol. 2019 Jan 23.. Abstract
submitted by kickingbird at Feb, 18, 2019 from J Gen Virol. 2019 Jan 23. (via https://www.ncbi.nlm.nih.gov/pubmed/30672726)
The accessory protein, PB1-F2, of influenza A virus (IAV) functions in a chicken host to prolong infectious virus shedding and thus the transmission window. Here we show that this delay in virus clearance ...
Bolte H, et al. Packaging of the Influenza Virus Genome Is Governed by a Plastic Network of RNA- and Nucleoprotein-Mediated Interactions. J Virol. 2019 Feb 5;93(4). Abstract
submitted by kickingbird at Feb, 17, 2019 from J Virol. 2019 Feb 5;93(4) (via https://www.ncbi.nlm.nih.gov/pubmed/30463968)
The genome of influenza A virus is organized into eight ribonucleoproteins, each composed of a distinct RNA segment bound by the viral polymerase and oligomeric viral nucleoprotein. Packaging sequences ...
White MC1, Tao H, Steel J, Lowen AC. H5N8 and H7N9 packaging signals constrain HA reassortment with a seasonal H3N2 influenza A virus. Proc Natl Acad Sci U S A. 2019 Feb 13. Abstract
submitted by kickingbird at Feb, 16, 2019 from Proc Natl Acad Sci U S A. 2019 Feb 13 (via https://www.ncbi.nlm.nih.gov/pubmed/30760600)
Influenza A virus (IAV) has a segmented genome, which (i) allows for exchange of gene segments in coinfected cells, termed reassortment, and (ii) necessitates a selective packaging mechanism to ensure ...
Ito M, et al. Characterization of Mouse Monoclonal Antibodies Against the HA of A(H7N9) Influenza Virus. Viruses. 2019 Feb 11;11(2). Abstract
submitted by kickingbird at Feb, 16, 2019 from Viruses. 2019 Feb 11;11(2) (via https://www.ncbi.nlm.nih.gov/pubmed/30754701)
Many cases of human infection with the H7N9 virus have been detected in China since 2013. H7N9 viruses are maintained in chickens and are transmitted to humans at live bird markets. During circulation ...
Vrijens P, et al. Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor β signalling pathway. J Gen Virol. 2019 Feb 14.. Abstract
submitted by kickingbird at Feb, 16, 2019 from J Gen Virol. 2019 Feb 14. (via https://www.ncbi.nlm.nih.gov/pubmed/30762518)
The possible resistance of influenza virus against existing antiviral drugs calls for new therapeutic concepts. One appealing strategy is to inhibit virus entry, in particular at the stage of internalization. ...
Kargarfard F, Sami A, Hemmatzadeh F, Ebrahimie E. Identifying mutation positions in all segments of influenza genome enables better differentiation between pandemic and seasonal strains. Gene. 2019 Feb 12. pii: S0378-1119(19)30058-7.. Abstract
submitted by kickingbird at Feb, 16, 2019 from Gene. 2019 Feb 12. pii: S0378-1119(19)30058-7. (via https://www.ncbi.nlm.nih.gov/pubmed/30769139)
Influenza has a negative sense, single-stranded, segmented RNA. In the context of pandemic influenza research, most studies have focused on variations in the surface proteins (Hemagglutinin and Neuraminidase). ...
Nikolaev EV, Zloza A, Sontag ED. Immunobiochemical Reconstruction of Influenza Lung Infection-Melanoma Skin Cancer Interactions. Front Immunol. 2019 Jan 28;10:4. Abstract
submitted by kickingbird at Feb, 14, 2019 from Front Immunol. 2019 Jan 28;10:4 (via https://www.ncbi.nlm.nih.gov/pubmed/30745900)
It was recently reported that acute influenza infection of the lung promoted distal melanoma growth in the dermis of mice. Melanoma-specific CD8+ T cells were shunted to the lung in the presence of the ...
Kwon JH, et al. Different pathogenicity of two strains of clade 22.214.171.124c H5N6 highly pathogenic avian influenza viruses bearing different PA and NS gene in domestic ducks. Virology. 2019 Jan 15;530:11-18. Abstract
submitted by kickingbird at Feb, 14, 2019 from Virology. 2019 Jan 15;530:11-18 (via https://www.ncbi.nlm.nih.gov/pubmed/30753976)
H5Nx clade 126.96.36.199 highly pathogenic avian influenza viruses (HPAIVs) have been disseminated to wide geographic regions since 2014. In 2016, five distinct genotypes (C-1 to C-5) of clade 188.8.131.52c H5N6 ...
Zhao L,Zhang X,Wu Z,Huang K,Sun X,Chen H, Jin M. The Downregulation of MicroRNA hsa-miR-340-5p in IAV-Infected A549 Cells Suppresses Viral Replication by Targeting RIG-I and OAS2. Mol Ther Nucleic Acids. 2019 Jan 10;14:509-519.. Abstract
submitted by kickingbird at Feb, 14, 2019 from Mol Ther Nucleic Acids. 2019 Jan 10;14:509-519. (via https://www.ncbi.nlm.nih.gov/pubmed/30753994)
The influenza A virus poses serious public health challenges worldwide. Strikingly, small noncoding microRNAs (miRNAs) that modulate gene expression are closely involved in antiviral responses, although ...
Wan YH, et al. Genetic characteristic of hemagglutinin of avian influenza A (H7N9) virus in Guizhou Province in 2017. Zhonghua Yu Fang Yi Xue Za Zhi. 2019 Feb 6;53(2):2. Abstract
submitted by kickingbird at Feb, 14, 2019 from Zhonghua Yu Fang Yi Xue Za Zhi. 2019 Feb 6;53(2):2 (via https://www.ncbi.nlm.nih.gov/pubmed/30744302)
The number of H7N9 bird flu cases was high and the situation was grim in guizhou province in 2017. To understand the molecular characteristics of the hemagglutinin gene (HA) and the risk of human infection ...
Bosco-Lauth AM, et al. Shedding of clade 184.108.40.206 H5N8 and H5N2 highly pathogenic avian influenza viruses in peridomestic wild birds in the U.S.. Transbound Emerg Dis. 2019 Feb 10. Abstract
submitted by kickingbird at Feb, 13, 2019 from Transbound Emerg Dis. 2019 Feb 10 (via https://www.ncbi.nlm.nih.gov/pubmed/30740920)
European starlings (Sturnus vulgaris), house sparrows (Passer domesticus) and rock pigeons (Columba livia) are all wild birds commonly found in large numbers in and around human dwellings and domestic ...
Wang R, et al. Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production. Autophagy. 2019 Feb 11.. Abstract
submitted by kickingbird at Feb, 13, 2019 from Autophagy. 2019 Feb 11. (via https://www.ncbi.nlm.nih.gov/pubmed/30741586)
Influenza A virus can evade host innate immune response that is involved in several viral proteins with complicated mechanisms. To date, how influenza A M2 protein modulates the host innate immunity remains ...
Kanekiyo M, et al. Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses. Nat Immunol. 2019 Feb 11. Abstract
submitted by kickingbird at Feb, 13, 2019 from Nat Immunol. 2019 Feb 11 (via https://www.ncbi.nlm.nih.gov/pubmed/30742080)
The present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy. This necessitates new approaches ...
Vuichard-Gysin D, et al. Development and validation of clinical prediction models to distinguish influenza from other viruses causing acute respiratory infections in children and adults. PLoS One. 2019 Feb 11;14(2):e0212050. Abstract
submitted by kickingbird at Feb, 13, 2019 from PLoS One. 2019 Feb 11;14(2):e0212050 (via https://www.ncbi.nlm.nih.gov/pubmed/30742654)
Predictive models have been developed for influenza but have seldom been validated. Typically they have focused on patients meeting a definition of infection that includes fever. Less is known about how ...
Mohl G, et al. Novel influenza inhibitors designed to target PB1 interactions with host importin RanBP5. Antiviral Res. 2019 Feb 8.. Abstract
submitted by kickingbird at Feb, 13, 2019 from Antiviral Res. 2019 Feb 8. (via https://www.ncbi.nlm.nih.gov/pubmed/30742842)
In search of novel targets for influenza inhibitors, a site on PB1 was selected for its high conservation and probable interaction with a host protein, RanBP5, that is key to nuclear import of PB1, where ...
Kwa?nik M, et al. Genetic Analysis of the M Gene of Equine Influenza Virus Strains Isolated in Poland, in the Context of the Asian-like Group Formation. J Vet Res. 2018 Dec 31;62(4):405-412. Abstract
submitted by kickingbird at Feb, 11, 2019 from J Vet Res. 2018 Dec 31;62(4):405-412 (via https://www.ncbi.nlm.nih.gov/pubmed/30729195)
Introduction: Traditionally, evolutionary analysis of equine influenza virus (EIV) is based on the HA gene. However, the specificity of the influenza virus enables the classification of viral strains into ...
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