Wang X, Jiang L, Wang G, Shi W, Hu Y, Wang B, Zeng. Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importin α7 is counteracted by TBK1-p62 axis-mediated autophagy. Cell Mol Immunol. 2022 Sep 2. Abstract
submitted by kickingbird at Sep, 5, 2022 from Cell Mol Immunol. 2022 Sep 2 (via https://www.nature.com/articles/s41423-022-00906-w)
As a major component of the viral ribonucleoprotein (vRNP) complex in influenza A virus (IAV), nucleoprotein (NP) interacts with isoforms of importin α family members, leading to the import of itself and ... Li T, Chen J, Zheng Q, Xue W, Zhang L, Rong R, Zha. Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses. Nat Commun. 2022 Sep 2;13(1):5182. Abstract
submitted by kickingbird at Sep, 3, 2022 from Nat Commun. 2022 Sep 2;13(1):5182 (via https://www.nature.com/articles/s41467-022-32926-5)
Influenza A viruses pose a significant threat globally each year, underscoring the need for a vaccine- or antiviral-based broad-protection strategy. Here, we describe a chimeric monoclonal antibody, C12H5, ... Goll JB, Jain A, Jensen TL, Assis R, Nakajima R, J. The antibody landscapes following AS03 and MF59 adjuvanted H5N1 vaccination. NPJ Vaccines. 2022 Aug 30;7(1):103. Abstract
submitted by kickingbird at Sep, 1, 2022 from NPJ Vaccines. 2022 Aug 30;7(1):103 (via https://www.nature.com/articles/s41541-022-00524-7)
Current seasonal and pre-pandemic influenza vaccines induce short-lived predominantly strain-specific and limited heterosubtypic responses. To better understand how vaccine adjuvants AS03 and MF59 may ... Sit THC, Sun W, Tse ACN, Brackman CJ, Cheng SMS, T. Novel Zoonotic Avian Influenza Virus A(H3N8) Virus in Chicken, Hong Kong, China. Emerg Infect Dis. 2022 Aug 29;28(10). Abstract
submitted by kickingbird at Aug, 31, 2022 from Emerg Infect Dis. 2022 Aug 29;28(10) (via https://pubmed.ncbi.nlm.nih.gov/36037827/)
Zoonotic and pandemic influenza continue to pose threats to global public health. Pandemics arise when novel influenza A viruses, derived in whole or in part from animal or avian influenza viruses, adapt ... Shen W, Wang Q, Wang Z, Liu M, Du Y, Yuan L, Han L. Specific Monoclonal Antibodies Targeting Unique HA Epitopes Block H7N9 Influenza A Viral Replication. J Virol. 2022 Aug 29:e0123822. Abstract
submitted by kickingbird at Aug, 31, 2022 from J Virol. 2022 Aug 29:e0123822 (via https://journals.asm.org/doi/10.1128/jvi.01238-22)
The H7N9 subtype influenza A viruses pose a serious threat to public health, and there is still a lack of vaccines or drugs for humans against H7N9 influenza viruses. In this study, we screened two monoclonal ... Zhai L, Zhang L, Jiang Y, Li B, Yang M, Victorovic. Broadly neutralizing antibodies recognizing different antigenic epitopes act synergistically against the influenza B virus. J Med Virol. 2022 Aug 30. Abstract
submitted by kickingbird at Aug, 31, 2022 from J Med Virol. 2022 Aug 30 (via https://onlinelibrary.wiley.com/doi/10.1002/jmv.28106)
The discovery of broadly neutralizing monoclonal antibodies against influenza viruses has raised hope for the successful development of new antiviral drugs. However, due to the speed and variety of mutations ... Zhu C, Zhang M, Fu W, He Y, Yang Y, Zhang L, Yuan. Comparison of H7N9 and H9N2 influenza infections in mouse model unravels the importance of early innate immune response in host protection. Front Cell Infect Microbiol. 2022 Aug 12;12:941078. Abstract
submitted by kickingbird at Aug, 30, 2022 from Front Cell Infect Microbiol. 2022 Aug 12;12:941078 (via https://www.frontiersin.org/articles/10.3389/fcimb.2022.9410)
The outcome of infection with influenza A virus is determined by a complex virus-host interaction. A new H7N9 virus of avian origin crossed the species barrier to infect humans, causing high mortality ... Uyeki TM, Hui DS, Zambon M, Wentworth DE, Monto AS. Influenza. Lancet. 2022 Aug 27;400(10353):693-706. Abstract
submitted by kickingbird at Aug, 29, 2022 from Lancet. 2022 Aug 27;400(10353):693-706 (via https://www.thelancet.com/journals/lancet/article/PIIS0140-6)
Annual seasonal influenza epidemics of variable severity caused by influenza A and B virus infections result in substantial disease burden worldwide. Seasonal influenza virus circulation declined markedly ... Hickerson BT, Adams SE, Bovin NV, Donnelly RP, Ily. Generation and characterization of interferon-beta-resistant H1N1 influenza A virus. Acta Virol. 2022 Aug 27. Abstract
submitted by kickingbird at Aug, 29, 2022 from Acta Virol. 2022 Aug 27 (via https://pubmed.ncbi.nlm.nih.gov/36029091/)
Interferons (IFNs) mediate innate antiviral activity against many types of viruses, including influenza viruses. In light of their potential use as anti-influenza agents, we examined whether resistance ... Liu H, Wu C, Pang Z, Zhao R, Liao M, Sun H. Phylogenetic and Phylogeographic Analysis of the Highly Pathogenic H5N6 Avian Influenza Virus in China. Viruses. 2022 Aug 11;14(8):1752. Abstract
submitted by kickingbird at Aug, 27, 2022 from Viruses. 2022 Aug 11;14(8):1752 (via https://www.mdpi.com/1999-4915/14/8/1752)
The clade 2.3.4.4b H5N8 avian influenza viruses (AIVs) have caused the loss of more than 33 million domestic poultry worldwide since January 2020. Novel H5N6 reassortants with hemagglutinin (HA) from clade ... Lu A, Yang J, Huang X, Huang X, Yin G, Cai Y, Feng. The Function behind the Relation between Lipid Metabolism and Vimentin on H9N2 Subtype AIV Replication. Viruses. 2022 Aug 18;14(8):1814. Abstract
submitted by kickingbird at Aug, 27, 2022 from Viruses. 2022 Aug 18;14(8):1814 (via https://www.mdpi.com/1999-4915/14/8/1814)
Avian influenza caused by H9N2 subtype avian influenza virus (AIV) poses a great threat to the healthy development of the poultry industry. Vimentin is closely related to intracellular lipid metabolism, ... Barrat-Charlaix P, Vaughan TG, Neher RA. TreeKnit: Inferring ancestral reassortment graphs of influenza viruses. PLoS Comput Biol. 2022 Aug 19;18(8):e1010394. Abstract
submitted by kickingbird at Aug, 23, 2022 from PLoS Comput Biol. 2022 Aug 19;18(8):e1010394 (via https://journals.plos.org/ploscompbiol/article?id=10.1371/jo)
When two influenza viruses co-infect the same cell, they can exchange genome segments in a process known as reassortment. Reassortment is an important source of genetic diversity and is known to have been ... Lee S, Zhang Y, Newhams M, Novak T, Thomas PG, Mou. DDX58 is Associated with Susceptibility to Severe Influenza Virus Infection in Children and Adolescents. J Infect Dis. 2022 Aug 20:jiac350. Abstract
submitted by kickingbird at Aug, 23, 2022 from J Infect Dis. 2022 Aug 20:jiac350 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
Background: Seasonal influenza virus infection causes a range of disease severity, including lower respiratory tract infection with respiratory failure. We evaluated the association of common variants ... Miao X, Feng M, Zhu O, Yang F, Yin Y, Yin Y, Chen. H5N8 Subtype Avian Influenza Virus Isolated from Migratory Birds Emerging in Eastern China Possessed a High Pathogenicity in Mammals. Transbound Emerg Dis. 2022 Aug 21. Abstract
submitted by kickingbird at Aug, 23, 2022 from Transbound Emerg Dis. 2022 Aug 21 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14685)
Novel H5N8 highly pathogenic avian influenza viruses (HPAIVs) bearing the clade 2.3.4.4b HA gene have been widely spread through wild migratory birds since 2020. One H5N8 HPAIV (A/Wild bird/Cixi/Cixi02/2020; ... Jakob C, Paul-Stansilaus R, Schwemmle M, Marquet R. The influenza A virus genome packaging network - complex, flexible and yet unsolved. Nucleic Acids Res. 2022 Aug 22:gkac688. Abstract
submitted by kickingbird at Aug, 23, 2022 from Nucleic Acids Res. 2022 Aug 22:gkac688 (via https://academic.oup.com/nar/advance-article/doi/10.1093/nar)
The genome of influenza A virus (IAV) consists of eight unique viral RNA segments. This genome organization allows genetic reassortment between co-infecting IAV strains, whereby new IAVs with altered genome ... Blaurock C, Pfaff F, Scheibner D, Hoffmann B, Fusa. Evidence for Different Virulence Determinants and Host Response after Infection of Turkeys and Chickens with Highly Pathogenic H7N1 Avian Influenza Virus. J Virol. 2022 Aug 22:e0099422. Abstract
submitted by kickingbird at Aug, 23, 2022 from J Virol. 2022 Aug 22:e0099422 (via https://journals.asm.org/doi/10.1128/jvi.00994-22)
Wild birds are the reservoir for all avian influenza viruses (AIV). In poultry, the transition from low pathogenic (LP) AIV of H5 and H7 subtypes to highly pathogenic (HP) AIV is accompanied mainly by ... Cui M, Huang Y, Wang X, Bian X, Du L, Yan Y, Gu J,. Genetic characterization and evolution of H6N6 subtype avian influenza viruses. Front Microbiol. 2022 Aug 1;13:963218. Abstract
submitted by kickingbird at Aug, 19, 2022 from Front Microbiol. 2022 Aug 1;13:963218 (via https://www.frontiersin.org/articles/10.3389/fmicb.2022.9632)
H6-subtype avian influenza virus (AIV) was prevalent in the world and could sporadically infect humans. Here, a new chicken-derived H6N6-subtype AIV strain A/chicken/Zhejiang/49/2021 (ZJ49) was isolated ... He D, Gu M, Hao X, Zhan T, Wang X, Wang X, Hu S, L. A dominant internal gene cassette of high pathogenicity avian influenza H7N9 virus raised since 2018. Virus Genes. 2022 Aug 16. Abstract
submitted by kickingbird at Aug, 17, 2022 from Virus Genes. 2022 Aug 16 (via https://link.springer.com/article/10.1007/s11262-022-01928-2)
The zoonotic H7N9 avian influenza virus emerged with the H9N2-origin internal gene cassette. Previous studies have reported that genetic reassortments with H9N2 were common in the first five human H7N9 ... Meng F, Yang H, Qu Z, Chen Y, Zhang Y, Zhang Y, Li. A Eurasian avian-like H1N1 swine influenza reassortant virus became pathogenic and highly transmissible due to mutations in its PA gene. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e220. Abstract
submitted by kickingbird at Aug, 16, 2022 from Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e220 (via https://www.pnas.org/doi/abs/10.1073/pnas.2203919119)
Previous studies have shown that the Eurasian avian-like H1N1 (EA H1N1) swine influenza viruses circulated widely in pigs around the world and formed multiple genotypes by acquiring non-hemagglutinin and ... Rimondi A, Olivera VS, Soria I, Parisi GD, Rumbo M. Few Amino Acid Mutations in H6 Influenza A Virus From South American Lineage Increase Viral Replication Efficiency in Poultry. Front Microbiol. 2022 Jul 27;13:953738. Abstract
submitted by kickingbird at Aug, 16, 2022 from Front Microbiol. 2022 Jul 27;13:953738 (via https://www.frontiersin.org/articles/10.3389/fmicb.2022.9537)
In chickens, infections due to influenza A virus (IAV) can be mild to severe and lethal. The study of IAV infections in poultry has been mostly limited to strains from the North American and Eurasian lineages, ... 5201 items, 20/Page, Page[34/261][|<<] [|<] [31] [32] [33] [34] [35] [36] [37] [38] [39] [40] [>|] [>>|] |
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